## UCHL1
- **UniProt:** P09936 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** ALP `…|ATG8 homolog processing, direct|Deubiquitination of ATG8 homologs` + UPS `DUBs and UBL demodifiers|UCH` ; **PN-node mapping:** ALP type mapped GO:0016579 protein deubiquitination (already_in_goa_exact); UPS group mapped GO:0101005 deubiquitinase activity (entailed_by_goa_closure).
- **Consistency:** Consistent. Deep research, review, and PN agree the core function is cysteine-type DUB / ubiquitin C-terminal hydrolase activity (GO:0004843) acting in protein deubiquitination (GO:0016579), with a substrate/context-specific LC3/autophagy branch. The review treats LC3/autophagy (GO:0016241 regulation of macroautophagy) as KEEP_AS_NON_CORE, matching the PN's "inhibits autophagosome formation through DUB activity" framing.
- **PN story / NEW pressure:** The ALP node "Deubiquitination of ATG8 homologs" describes a function GO cannot express specifically — the review proposes a NEW term **"ATG8-family protein deubiquitination"** (parent GO:0016579), justified by PMID:29462615. OLS search returns no existing GO term for ATG8/LC3 deubiquitination, so this is a genuine candidate (verified absent). Verdict: the ATG8-DUB story is real but only loosely captured by broad GO:0016579 today; defensible NEW candidate (unverified as an existing term, correctly proposed not asserted).
- **Mapping strategy:** This gene does not change the node scope. PN maps the ALP type to the broad parent GO:0016579 because no ATG8-specific term exists — consistent with the review. Minor mismatch: PN's UPS group projects GO:0101005 deubiquitinase activity, whereas GOA/review use the child GO:0004843 cysteine-type deubiquitinase activity; entailed_by_goa_closure correctly reflects that GO:0004843 entails GO:0101005, so no conflict.
- **Evidence alignment:** PN ALP cites PMID:29462615 (UCHL1 inhibits autophagosome formation via DUB) — present in the review supporting the autophagy non-core annotation. PN UPS row is domain-based (IPR001578), matched by the review's deep enzymology set (PMID:9521656, 8639624, 16475834, 20439756, 23359680). Good overlap.
- **Verdict:** Consistent; the only actionable item is the proposed ATG8-family-deubiquitination NEW term (candidate, no existing GO equivalent) and the GO:0101005-vs-GO:0004843 granularity note.