## UFC1
- **UniProt:** Q9Y3C8 · **batch:** proteostasis-batch-2026-06-07c · **review status:** complete (core MF GO:0061657; proposed_new_terms: [])
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|UFMylation`; `ALP|...|ERphagy|UFMylation of ER proteins`; `UPS|E2 conjugating enzymes|UFMylation|no family designation` ; **PN-node mapping:** UFMylation type→GO:0071569; ERphagy→GO:0061709; E2 group→GO:0019787 (broad UBL transferase activity, entailed_by_goa_closure); RQC group→GO:0006515.
- **Consistency:** Strong. Notes/review/PN agree UFC1 is the UFM1 E2 (accepts UFM1 from UBA5, Cys-116 thioester, works with UFL1/DDRGK1). Review ACCEPTs GO:0061657 (UFM1 conjugating enzyme activity, IDA x4), GO:0071568 (transferase, IBA), GO:0071569; ERphagy/ER-stress KEEP_AS_NON_CORE. extracellular exosome MARK_AS_OVER_ANNOTATED. No contradictions.
- **PN story / NEW pressure:** All PN assertions captured in GOA/review. GO:0006515 (verified) projected new_to_goa via RQC group is broad; UFC1's RQC role is via ufmylation (annotated). Conclusion: **already captured**; GO:0006515 over-reaches as a direct UFC1 term.
- **Mapping strategy:** Specific-vs-broad MF: PN E2-group projects broad GO:0019787 (ubiquitin-like protein transferase activity), explicitly entailed_by_goa_closure of the gene-level specific GO:0061657 — so PN's term is strictly an ancestor (TOMM20/HSPA8 "broader" precedent: keep as context, do not propagate over the specific). Review's GO:0061657 (E2) is the correct gene-level MF. UFC1 does not change the node.
- **Evidence alignment:** PN E2 row cites "19452197 / rev" (not in review); review uses cascade/structure PMIDs (15071506, 36121123, 38383789, 37036982 — the last three also in GOA as IDA/IMP for GO:0061657). PN ERphagy row cites the ER-phagy screen (PMID:32160526, in notes). Good thematic overlap; PN's family-review PMID is non-overlapping by design.
- **Verdict:** Consistent and complete; PN E2/UFMylation/ERphagy story fully captured by specific GO:0061657 + GO:0071569. PN's broad GO:0019787 is an ancestor only; GO:0006515 not warranted as a direct add.