## UFD1
- **UniProt:** Q92890 · **batch:** proteostasis-batch-2026-06-07c · **review status:** complete (2 core_functions, both GO:0031593; large protein-binding set triaged)
- **PN placement:** `ER proteostasis|...|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories`; `Translation|...|Ribosome-associated QC|VCP system for RQC`; `UPS|VCP and associated proteins|adaptors|SHP|UT3`; `UPS|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|...UT3` ; **PN-node mapping:** ERAD group→GO:0036503 (exact); SHP/UT3 subtype→GO:0034098 (VCP-NPL4-UFD1 complex); ERAD-cofactor type→GO:0097466 (glycoprotein ERAD, more_specific_than_existing); RQC type→no_mapping.
- **Consistency:** Strong. Notes/review/PN agree UFD1 is the p97/VCP ubiquitin-binding cofactor (UFD1-NPL4 heterodimer; ERAD retrotranslocation; also RQC, mitosis, immunity). NOTE: UFD1 is NOT a UFMylation-cascade member despite the name similarity — it is "ubiquitin fusion degradation 1," a p97 adaptor. The review/PN both treat it correctly as a UPS/ERAD/VCP gene; no false UFM1 conflation. Review ACCEPTs GO:0036503, GO:0034098 (8x in GOA), GO:0031593, GO:0030970, GO:0036501 (UFD1-NPL4 complex), GO:0036435 (K48-polyUb binding). No contradictions.
- **PN story / NEW pressure:** Well captured. GO:0036503 (ERAD) and GO:0034098 (complex) are in GOA/review. PN's GO:0097466 (ubiquitin-dependent glycoprotein ERAD pathway; verify before any add) is flagged more_specific_than_existing — UFD1 is a general ERAD adaptor, not glycoprotein-specific, so this projection over-reaches. PN RQC type is correctly no_mapping; review captures RQC via GO:0072344 (NAS) + GO:1990116 as KEEP_AS_NON_CORE. The MF core GO:0031593 (polyubiquitin-modification-dependent protein binding) is annotated. Conclusion: **already captured**; GO:0097466 over-reaches.
- **Mapping strategy:** PN node is sound: ERAD group→GO:0036503 exact and the SHP/UT3 subtype→GO:0034098 complex are precise and match the review. The only caution is the ERAD-cofactor type→GO:0097466 (glycoprotein-specific) being narrower/skewed vs UFD1's general adaptor role — keep ERAD at GO:0036503, do not propagate the glycoprotein-specific child. UFD1 does not change the node.
- **Evidence alignment:** PN cites PMID:28451587 (SHP motif) and 36736315 (IPR055417 domain) — neither in review YAML (domain/signature citations); review uses UniProt + p97/ERAD literature. Divergence is benign; no shared functional PMID but no conflict.
- **Verdict:** Consistent and complete; correctly handled as a p97/ERAD adaptor (not a UFMylation gene). PN GO:0036503/GO:0034098 match the review; PN's glycoprotein-specific GO:0097466 over-reaches — keep general ERAD.