## UFL1
- **UniProt:** O94874 · **batch:** proteostasis-batch-2026-06-07c · **review status:** complete (core MF GO:0061666; large annotation set triaged)
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|UFMylation`; `ALP|...|ERphagy|UFMylation of ER proteins`; `UPS|E3 ubiquitin and UBL ligases|UBL modifiers|UFMylation` ; **PN-node mapping:** UFMylation type→GO:0071569; ERphagy→GO:0061709; E3 class→GO:0061630 (context only); E3 UBL-modifier type→no_mapping.
- **Consistency:** Strong. Notes/review/PN agree UFL1 is the UFM1 E3 (UREL: UFL1+DDRGK1+CDK5RAP3; scaffold-type E3 activating UFC1; principal substrate RPL26 → 60S recycling). Review ACCEPTs GO:0061666 (UFM1 ligase activity, IDA x16), GO:0071568, GO:0071569, ER membrane; downstream DNA-damage/immune/ERphagy roles KEEP_AS_NON_CORE. No contradictions.
- **PN story / NEW pressure:** All PN assertions captured. GO:0006515 (verified) projected new_to_goa via RQC group is broad; UFL1's RQC role = ufmylation-driven 60S recycling (GO:0071569 annotated; review core_function explicitly describes RPL26→recycling). Conclusion: **already captured**; GO:0006515 over-reaches as a direct UFL1 term. (Note: the more specific GO:0072344 rescue-of-stalled-ribosome appears 4x in UFL1 GOA, a better fit than GO:0006515 if any RQC process were to be added.)
- **Mapping strategy:** PN node correctly leaves the E3 UBL-modifier type at no_mapping and the E3 class at context-only GO:0061630 (ubiquitin protein ligase activity) — appropriately broad, not propagated. The gene-level specific MF is GO:0061666 (review). UFL1 does not change the node.
- **Evidence alignment:** PN E3 row cites PMID:20018847 (shared — review uses it 7x, in GOA as IDA for GO:0061666), plus 25852645 and 20368332 (not in review; family/review citations). Good core-evidence overlap on the E3-ligase identification paper.
- **Verdict:** Consistent and complete; PN E3/UFMylation/ERphagy story fully captured by GO:0061666 + GO:0071569. GO:0006515 broader than UFL1's already-annotated GO:0072344/GO:0071569 — not warranted as a direct add.