## USP10
- **UniProt:** Q14694 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** TR `Cytosolic translation|Ribosome-associated QC|Deubiquitination`; ALP `…|ATG8 homolog processing, direct|Deubiquitination of ATG8 homologs`; UPS `DUBs and UBL demodifiers|USP|Ataxin-2, C term|other` ; **PN-node mapping:** RQC type→GO:0101005 deubiquitinase activity; RQC group→GO:0006515 protein QC for misfolded/incompletely synthesized proteins (new_to_goa); ALP type→GO:0016579 protein deubiquitination (already_in_goa); UPS group→GO:0101005.
- **Consistency:** Consistent across all three branches. Notes, review, and PN agree on a core cysteine-type DUB (GO:0004843) acting on p53, CFTR, LC3B, and 40S ribosomal proteins, with RQC and ATG8 as direct substrate contexts. Review accepts the RQC story strongly (GO:0072344 rescue of stalled cytosolic ribosome, GO:0035520 monoubiquitinated protein deubiquitination, GO:0022626 cytosolic ribosome) and keeps autophagy/LC3B as KEEP_AS_NON_CORE.
- **PN story / NEW pressure:** The RQC group's GO:0006515 (verified real, non-obsolete) is new_to_goa and the dossier rationale notes GO lacks a dedicated ribosome-associated-QC term. The review instead captures RQC via the more specific, already-curatable GO:0072344 + GO:0035520 (both in GOA, IDA-supported). So the function is captured at finer grain than the PN projection; GO:0006515 would be a defensible but broader add. Verdict: already captured (more specifically) — GO:0006515 is broader than the review's RQC terms.
- **Mapping strategy:** USP10 supports the RQC node well. The PN-projected GO:0006515 is broader than the review's GO:0072344/GO:0035520 — a precedent-style "broader than review" case (cf. TOMM20/HSPA8). MF granularity note: PN projects GO:0101005 deubiquitinase activity while GOA/review use child GO:0004843; entailed_by_goa_closure is correct, no conflict. ALP→GO:0016579 matches.
- **Evidence alignment:** PN RQC row has no titled reference; ALP cites PMID:33577797 (USP10 deubiquitinates LC3B) — present in review (non-core autophagy). UPS row cites "19734957/rev". Review's RQC evidence: PMID:31981475, 34348161, 34469731 (40S/iRQC) — richer than PN. Strong overlap on the LC3B paper.
- **Verdict:** Consistent; RQC and ATG8 stories captured (RQC more specifically than the PN's GO:0006515, which is broader). No NEW term needed.