## UVRAG
- **UniProt:** Q9P2Y5 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** ALP `…|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component` ; **PN-node mapping:** type mapped/ok_for_propagation GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II (more_specific_than_existing_goa); group context_only GO:0035032 (class III PI3K complex); class context_only GO:0016236 macroautophagy.
- **Consistency:** Strong agreement. Deep research, review, and PN all place UVRAG as the regulatory/adaptor subunit defining the type II (UVRAG-containing) class III PI3K complex (PI3KC3-C2), driving autophagosome maturation and HOPS/SNARE-dependent late-endosome/lysosome fusion. The review's PN-core framing (autophagosome maturation, positive regulation of autophagy) matches the dossier Notes verbatim (mTOR-RUBCN regulation, HOPS recruitment).
- **PN story / NEW pressure:** GO:0034272 (verified real, non-obsolete) is the projected complex term. GOA currently has only the generic parent GO:0035032; the review MODIFYs GO:0035032 → GO:0034272 (and also narrows GO:0032991/GO:0043933 to GO:0034272). So the PN's more_specific_than_existing_goa status is exactly right and the review already proposes the same upgrade. Verdict: already captured by the review's proposed MODIFY; no new NEW term needed.
- **Mapping strategy:** UVRAG genuinely sharpens the node — it is the defining type II component, so projecting the narrower GO:0034272 (vs the parent GO:0035032 the group keeps as context_only) is well justified, not over-reach. Scope ok_for_propagation at the leaf, context_only at the group, is the correct split (component leaves propagate complex membership; regulator/context group does not).
- **Evidence alignment:** PN cites PMID:18843052 (Atg14L/Rubicon reciprocal regulation), PMID:16799551-equivalent Beclin1-UVRAG work, plus the class-C VPS paper and review articles. Review uses the same anchors: PMID:18843052, PMID:16799551 (positive regulator of Beclin1-PI3KC3), PMID:24550300 (SNARE/C-Vps), PMID:28306502 (Pacer/HOPS), PMID:18552835. Excellent overlap.
- **Verdict:** Consistent and well-supported; the review's GO:0034272 MODIFY is the correct, verified specific complex term and aligns with the PN projection. Best-aligned gene of the set.