## VPS37A
- **UniProt:** Q8NEZ2 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** 3 rows, ALP+UPS — (1) ALP `Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-I complex component`; (2) ALP same group → `Localization of the ESCRT-III complex`; (3) UPS `Ubiquitin and UBL binding → trafficking → ESCRT-I complex → UEV (Type 2)`. **PN-node mapping:** ESCRT-I-component leaf=mapped→GO:0000813; sealing group=mapped→GO:0000045; ESCRT-III-localization leaf=no_mapping; macroautophagy class + UPS nodes=context_only/no_mapping. **Projected:** GO:0000045 (more_specific_than_existing_goa), GO:0000813 (already_in_goa_exact).
- **Consistency:** Strongly consistent. VPS37A is the one VPS37 paralog with direct mammalian phagophore-closure evidence (PMID:31519728), and the review uniquely adds GO:0000045 as a NEW annotation (plus MODIFY of GO:0006612/GO:0016236→GO:0000045). PN's two projections (GO:0000813 ESCRT-I; GO:0000045 autophagosome assembly) match the review exactly. The UEV/UPS placement aligns with ESCRT-I/ubiquitin cargo sorting (review accepts GO:0043162, GO:0036258, GO:0000813).
- **PN story / NEW pressure:** Already captured. PN asserts phagophore sealing → the review independently makes GO:0000045 a NEW term (verified real via OLS) supported by VPS37A-on-phagophore + VPS28/CHMP2A recruitment evidence. No additional new term warranted; PN adds nothing the review lacks.
- **Mapping strategy:** No change. VPS37A is the strongest evidence anchor for the sealing-group→GO:0000045 mapping; its direct IMP/PMID:31519728 data justify the group projection for this gene. ESCRT-III-localization leaf no_mapping is correct (mixed gene set). Unlike the TOMM20/HSPA8 over-reach pattern, this projection is narrower than GOA and the review agrees.
- **Evidence alignment:** Strong overlap. PN cites the ESCRT-I scaffold paper (=PMID:32424346) and "VPS37A directs ESCRT recruitment for phagophore closure" (=PMID:31519728), both load-bearing in the review. PN's MDPI "Key Regulators of Autophagosome Closure" review is not cited; the review uses primary literature instead.
- **Verdict:** Fully consistent; PN projections match the review's accepted/NEW terms. No edits needed.