## ZNF598
- **UniProt:** Q86UK7 · **batch:** proteostasis-batch-2026-06-07c · **review status:** COMPLETE
- **PN placement:** TR `Cytosolic translation|Ribosome-associated QC|Ribosomal rescue`; UPS `E3 ubiquitin and UBL ligases|RING|other|other` ; **PN-node mapping:** RQC type→GO:0072344 rescue of stalled cytosolic ribosome (mapped, already_in_goa_exact); RQC group→GO:0006515 protein QC for misfolded/incompletely synthesized proteins (new_to_goa); E3 RING group→GO:0061630 ubiquitin protein ligase activity (already_in_goa_exact); class→GO:0061630 (context_only); type/subtype/branch = no_mapping.
- **Consistency:** Fully consistent and exemplary. Notes, review, and PN agree ZNF598 is the RING E3 (Hel2 ortholog) that senses ribosome collisions and ubiquitinates 40S eS10/RPS10, uS3/RPS3 (mono) and uS10/RPS20 (K63) via UBE2D3 to initiate RQC. Review captures this richly: GO:0061630 (IDA), GO:0170011 stalled ribosome sensor activity (IDA), GO:0072344 (many IDA/IMP), GO:1990116, GO:0070534, GO:0006513, GO:0043022. The two PN-projected MF/process targets (GO:0072344, GO:0061630) are both already_in_goa_exact and present in the review.
- **PN story / NEW pressure:** PN's RQC-group GO:0006515 (verified real, non-obsolete) is the only new_to_goa projection. The review already captures the RQC process at finer grain via GO:0072344 (rescue) AND GO:1990116 (ribosome-associated ubiquitin-dependent protein catabolic process, verified real) — both more specific than GO:0006515. Conclude: already captured (more specifically); GO:0006515 would be a defensible-but-broader add, not required.
- **Mapping strategy:** ZNF598 strongly supports both nodes; it does not change the mapping. PN-projected GO:0006515 is broader than the review's GO:0072344/GO:1990116 — a "broader than review" case (cf. TOMM20/HSPA8/RAB7A precedent). E3 RING group→GO:0061630 exact-matches the review core MF. Status/scope correct throughout.
- **Evidence alignment:** PN UPS row cites "19489725/rev" (a RING E3 review); RQC TR row has no titled reference. The review's foundational RQC papers (PMID:28065601, 28132843, 28685749, 30293783, 36302773, 32099016) are absent from the PN rows — large divergence, with the review far richer and PN citing only a generic E3 review.
- **Verdict:** Consistent and well-captured; ZNF598 is the canonical RQC-initiating E3. PN's GO:0006515 is broader than the review's GO:0072344/GO:1990116; no NEW term needed.