gene_symbol	gene_name	pn_code	branch	class	group	type	subtype	mapping_file	mapping_subject_level	mapping_subject_code	mapping_scope	target_go_id	target_go_label	representative_genes	conditions	goa_status	supporting_goa_terms	rationale	notes	references
HSPA1A		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
HSPA1B		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
HSPA1L		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
HSPA2		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
HSPA6		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
HSPA8		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		already_in_goa_exact	GO:0140662 ATP-dependent protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
HSPA14		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6		more_specific_than_existing_goa	GO:0006457 protein folding;GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity.	proteostasis-workbook-2024; file:human/HSPA12A/HSPA12A-notes.md; file:human/HSPA12B/HSPA12B-notes.md; PMID:12552099
DNAJA1		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJA2		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJA4		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB1		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB2		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB4		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB5		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB6		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB7		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB8		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC2		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC6		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0031072 heat shock protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC7		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0031072 heat shock protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC8		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC9		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0031072 heat shock protein binding;GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC12		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC13		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC16		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		new_to_goa		In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC17		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC21		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC24		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		new_to_goa		In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC25		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		new_to_goa		In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC25-GNG10		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		no_local_goa		In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
GAK		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC27		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
SACS		Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
HSPH1		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSP110/GRP170 subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	HSP110/GRP170 subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
HSPA4		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSP110/GRP170 subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	HSP110/GRP170 subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
HSPA4L		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSP110/GRP170 subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	HSP110/GRP170 subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
BAG1		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|BAG domain subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	BAG domain subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
BAG2		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|BAG domain subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	BAG domain subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
BAG3		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|BAG domain subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	BAG domain subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
BAG4		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|BAG domain subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	BAG domain subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
BAG5		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|BAG domain subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	BAG domain subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
HSPBP1		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSPBP1 subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	HSPBP1 subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ST13		Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange inhibitor|TPR domain subtype	Cytonuclear proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange inhibitor	TPR domain subtype	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange inhibitor	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	ST13		already_in_goa_exact	GO:0030544 Hsp70 protein binding	This PN type is represented by ST13/HIP, an HSP70 nucleotide-exchange inhibitor. The shared mechanistic assertion is Hsp70 protein binding.		proteostasis-workbook-2024; proteostasis-ms1
TCP1		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT2		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT3		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT4		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT5		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT6A		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT6B		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT7		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT8		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
CCT8L2		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC subunit		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit	ok_for_propagation_to_go	GO:0005832	chaperonin-containing T-complex	TCP1;CCT2;CCT3;CCT4;CCT5		already_in_goa_exact	GO:0005832 chaperonin-containing T-complex	This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class.		proteostasis-workbook-2024; proteostasis-ms1
TBCA		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC cochaperone	Tubulin folding	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	ok_for_propagation_to_go	GO:0007023	post-chaperonin tubulin folding pathway	TBCA;TBCB;TBCC;TBCD;TBCE		already_in_goa_exact	GO:0007023 post-chaperonin tubulin folding pathway	This PN subtype is the tubulin-folding cofactor branch downstream of CCT/TRiC. The GO post-chaperonin tubulin folding pathway term captures the shared pathway role.		proteostasis-workbook-2024; proteostasis-ms1
TBCB		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC cochaperone	Tubulin folding	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	ok_for_propagation_to_go	GO:0007023	post-chaperonin tubulin folding pathway	TBCA;TBCB;TBCC;TBCD;TBCE		already_in_goa_exact	GO:0007023 post-chaperonin tubulin folding pathway	This PN subtype is the tubulin-folding cofactor branch downstream of CCT/TRiC. The GO post-chaperonin tubulin folding pathway term captures the shared pathway role.		proteostasis-workbook-2024; proteostasis-ms1
TBCC		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC cochaperone	Tubulin folding	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	ok_for_propagation_to_go	GO:0007023	post-chaperonin tubulin folding pathway	TBCA;TBCB;TBCC;TBCD;TBCE		already_in_goa_exact	GO:0007023 post-chaperonin tubulin folding pathway	This PN subtype is the tubulin-folding cofactor branch downstream of CCT/TRiC. The GO post-chaperonin tubulin folding pathway term captures the shared pathway role.		proteostasis-workbook-2024; proteostasis-ms1
TBCD		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC cochaperone	Tubulin folding	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	ok_for_propagation_to_go	GO:0007023	post-chaperonin tubulin folding pathway	TBCA;TBCB;TBCC;TBCD;TBCE		already_in_goa_exact	GO:0007023 post-chaperonin tubulin folding pathway	This PN subtype is the tubulin-folding cofactor branch downstream of CCT/TRiC. The GO post-chaperonin tubulin folding pathway term captures the shared pathway role.		proteostasis-workbook-2024; proteostasis-ms1
TBCE		Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	Cytonuclear proteostasis	Chaperone	CCT/TRiC system	CCT/TRiC cochaperone	Tubulin folding	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding	ok_for_propagation_to_go	GO:0007023	post-chaperonin tubulin folding pathway	TBCA;TBCB;TBCC;TBCD;TBCE		already_in_goa_exact	GO:0007023 post-chaperonin tubulin folding pathway	This PN subtype is the tubulin-folding cofactor branch downstream of CCT/TRiC. The GO post-chaperonin tubulin folding pathway term captures the shared pathway role.		proteostasis-workbook-2024; proteostasis-ms1
HSPB1		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		already_in_goa_exact	GO:0044183 protein folding chaperone	This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB2		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB3		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB6		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		already_in_goa_exact	GO:0044183 protein folding chaperone	This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB7		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB8		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB9		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
CRYAA		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
CRYAB		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		more_specific_than_existing_goa	GO:0006457 protein folding	This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
ODF1		Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis	Chaperone	small HSP system	small HSP		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		new_to_goa		This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSP90AA1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSP90AA1;HSP90AB1		already_in_goa_exact	GO:0140662 ATP-dependent protein folding chaperone	In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class.	This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts.	proteostasis-workbook-2024
HSP90AB1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90		chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSP90AA1;HSP90AB1		already_in_goa_exact	GO:0140662 ATP-dependent protein folding chaperone	In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class.	This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts.	proteostasis-workbook-2024
CACYBP		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
CHORDC1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
CYB5R4		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		new_to_goa		This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
DNAAF11		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
DNAAF6		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
HACD3		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
ITGB1BP2		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
NUDC		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
NUDCD1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
NUDCD2		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
NUDCD3		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
PIH1D1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
PIH1D2		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
PTGES3		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
USP19		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
NASP		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
TTC13		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		no_local_goa		This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
TTC31		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		no_local_goa		This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
SUGT1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR and CS domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	TPR and CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
UNC45A		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and Armadillo domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and Armadillo domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
UNC45B		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and Armadillo domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and Armadillo domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
FKBP4		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0031072 heat shock protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
FKBP5		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0031072 heat shock protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
FKBP8		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
FKBPL		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
RPAP3		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and RPAP3-like C-terminal domain containing	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	CC-TPR and RPAP3-like C-terminal domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
AHSA1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
CDC37		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
CDC37L1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0031072 heat shock protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
FNIP1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
FNIP2		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
PDCL3		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
S100A1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
TSC1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		already_in_goa_exact	GO:0051879 Hsp90 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
ZMYND10		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
RUVBL1		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
RUVBL2		Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	Cytonuclear proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	no characteristic domain	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.	AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:26884463; file:human/TTC28/TTC28-ai-review.yaml; file:human/TTC28/TTC28-notes.md; PMID:23036704; PMID:39630868
TTC12		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and Armadillo domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and Armadillo domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC4		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and Cns1/TTC4 wheel domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and Cns1/TTC4 wheel domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		entailed_by_goa_closure	GO:0030544 Hsp70 protein binding;GO:0051879 Hsp90 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
DNAAF4		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and CS domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and CS domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC7		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and J domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and J domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		already_in_goa_exact	GO:0031072 heat shock protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
SMYD4		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and methyltransferase domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and methyltransferase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
PPP5C		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and phosphatase domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and phosphatase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		already_in_goa_exact	GO:0031072 heat shock protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
AIP		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
AIPL1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
FKBP6		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		entailed_by_goa_closure	GO:0051879 Hsp90 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
PPID		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and PPIase domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		already_in_goa_exact	GO:0031072 heat shock protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
SPAG1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and RPAP3-like C-terminal domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and RPAP3-like C-terminal domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		new_to_goa		This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
SGTA		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and SGTA dimerization domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and SGTA dimerization domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
SGTB		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and SGTA dimerization domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and SGTA dimerization domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		entailed_by_goa_closure	GO:0030544 Hsp70 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
STIP1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and STI/HOP domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR and STI/HOP domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		entailed_by_goa_closure	GO:0051879 Hsp90 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
LONRF3		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
LONRF3		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	LONRF3;STUB1;TTC3;WDTC1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype explicitly denotes TPR-containing ubiquitin ligases in the HSP70/HSP90 co-chaperone branch. The shared catalytic assertion is ubiquitin protein ligase activity.		proteostasis-workbook-2024; proteostasis-ms1
STUB1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		already_in_goa_exact	GO:0031072 heat shock protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
STUB1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	LONRF3;STUB1;TTC3;WDTC1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype explicitly denotes TPR-containing ubiquitin ligases in the HSP70/HSP90 co-chaperone branch. The shared catalytic assertion is ubiquitin protein ligase activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC3		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC3		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	LONRF3;STUB1;TTC3;WDTC1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype explicitly denotes TPR-containing ubiquitin ligases in the HSP70/HSP90 co-chaperone branch. The shared catalytic assertion is ubiquitin protein ligase activity.		proteostasis-workbook-2024; proteostasis-ms1
WDTC1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
WDTC1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain and Ub ligase	chaperone_systems.yaml	subtype	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	LONRF3;STUB1;TTC3;WDTC1		new_to_goa		This PN subtype explicitly denotes TPR-containing ubiquitin ligases in the HSP70/HSP90 co-chaperone branch. The shared catalytic assertion is ubiquitin protein ligase activity.		proteostasis-workbook-2024; proteostasis-ms1
TOMM34		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		already_in_goa_exact	GO:0031072 heat shock protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TOMM70		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC1		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC9		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		no_local_goa		This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC9B		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0003674 molecular_function	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
TTC9C		Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	Cytonuclear proteostasis	Chaperone	HSP70-HSP90 system integration	HSP70-HSP90 joint cochaperone	CC-TPR domain containing	chaperone_systems.yaml	type	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	ok_for_propagation_to_go	GO:0031072	heat shock protein binding	TTC12;TTC4;DNAAF4;DNAJC7;SMYD4		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity.		proteostasis-workbook-2024; proteostasis-ms1
AIP		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
AIP		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
AIPL1		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
AIPL1		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP1A		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP1A		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP1B		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP1B		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP3		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP3		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP4		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP4		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP5		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP5		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP6		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		new_to_goa		This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP6		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		new_to_goa		This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP8		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP8		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
CWC27		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		new_to_goa		This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
CWC27		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		new_to_goa		This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
NKTR		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
NKTR		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIA		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIA		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4A		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4A		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4C		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4C		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4D		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4D		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4E		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4E		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4F		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4F		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4G		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIAL4G		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPID		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPID		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIE		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIE		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIG		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIG		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIH		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIH		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL1		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL1		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL2		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		new_to_goa		This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL2		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		new_to_goa		This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL3		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL3		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL4		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL4		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL6		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		new_to_goa		This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIL6		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		new_to_goa		This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPWD1		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPWD1		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
RANBP2		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	group	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		new_to_goa		This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
RANBP2		Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		chaperone_systems.yaml	type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	CWC27;NKTR;PPIA;PPIAL4A;PPIAL4C		new_to_goa		This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
HSPA5		ER proteostasis|Chaperone|HSP70 system|HSP70	ER proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA5;HSPA13		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping.	proteostasis-workbook-2024
HSPA13		ER proteostasis|Chaperone|HSP70 system|HSP70	ER proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA5;HSPA13		more_specific_than_existing_goa	GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping.	proteostasis-workbook-2024
DNAJB9		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB11		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB12		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB13		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJB14		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC1		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC3		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC5		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC5B		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC5G		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		new_to_goa		In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC10		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC14		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC18		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC22		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
SEC63		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC28		ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
HYOU1		ER proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSP110/GRP170 subtype	ER proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	HSP110/GRP170 subtype	chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
SIL1		ER proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSPBP1 subtype	ER proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	HSPBP1 subtype	chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
HSP90B1		ER proteostasis|Chaperone|HSP90 system|HSP90	ER proteostasis	Chaperone	HSP90 system	HSP90		chaperone_systems.yaml	type	ER proteostasis|Chaperone|HSP90 system|HSP90	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSP90B1		already_in_goa_exact	GO:0140662 ATP-dependent protein folding chaperone	In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class.	This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts.	proteostasis-workbook-2024
MZB1		ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|Folding of IGM and IgA	ER proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	Folding of IGM and IgA	er_proteostasis.yaml	type	ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	MZB1;CNPY3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups ER HSP90/GRP94 cochaperones. Hsp90 protein binding is the shared mechanistic assertion.		proteostasis-workbook-2024; proteostasis-ms1
CNPY3		ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|Folding of TLRs	ER proteostasis	Chaperone	HSP90 system	HSP90 cochaperone	Folding of TLRs	er_proteostasis.yaml	type	ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ok_for_propagation_to_go	GO:0051879	Hsp90 protein binding	MZB1;CNPY3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type groups ER HSP90/GRP94 cochaperones. Hsp90 protein binding is the shared mechanistic assertion.		proteostasis-workbook-2024; proteostasis-ms1
AGR2		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
AGR3		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
CASQ1		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
CASQ2		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC10		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
ERP27		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
ERP29		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
ERP44		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
P4HB		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
PDIA2		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
PDIA3		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
PDIA4		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
PDIA5		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
PDIA6		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
PDILT		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TMX1		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TMX2		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TMX3		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TMX4		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TXNDC5		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TXNDC11		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TXNDC12		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
TXNDC16		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
QSOX1		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
QSOX2		ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis	Folding enzyme	Protein disulfide isomerases			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
ERO1A		ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ER proteostasis	Folding enzyme	Protein disulfide isomerases	Protein disulfide isomerase reoxidation		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
ERO1A		ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ER proteostasis	Folding enzyme	Protein disulfide isomerases	Protein disulfide isomerase reoxidation		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	ERO1A;ERO1B		new_to_goa		This PN type is a mechanistic substep within the PDI family and still belongs under the same GO activity umbrella at propagation scope.		proteostasis-workbook-2024; proteostasis-ms1
ERO1B		ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ER proteostasis	Folding enzyme	Protein disulfide isomerases	Protein disulfide isomerase reoxidation		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		new_to_goa		This PN group captures the canonical ER protein-disulfide-isomerase folding enzymes. GO protein disulfide isomerase activity is the cleanest propagation target for the family bucket.		proteostasis-workbook-2024; proteostasis-ms1
ERO1B		ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ER proteostasis	Folding enzyme	Protein disulfide isomerases	Protein disulfide isomerase reoxidation		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	ERO1A;ERO1B		new_to_goa		This PN type is a mechanistic substep within the PDI family and still belongs under the same GO activity umbrella at propagation scope.		proteostasis-workbook-2024; proteostasis-ms1
PRDX1		ER proteostasis|Folding enzyme|Peroxiredoxins	ER proteostasis	Folding enzyme	Peroxiredoxins			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peroxiredoxins	ok_for_propagation_to_go	GO:0051920	peroxiredoxin activity	PRDX1;PRDX3;PRDX4		already_in_goa_exact	GO:0051920 peroxiredoxin activity	This PN group denotes ER peroxiredoxins. The shared molecular function is peroxiredoxin activity.		proteostasis-workbook-2024; proteostasis-ms1
PRDX3		ER proteostasis|Folding enzyme|Peroxiredoxins	ER proteostasis	Folding enzyme	Peroxiredoxins			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peroxiredoxins	ok_for_propagation_to_go	GO:0051920	peroxiredoxin activity	PRDX1;PRDX3;PRDX4		already_in_goa_exact	GO:0051920 peroxiredoxin activity	This PN group denotes ER peroxiredoxins. The shared molecular function is peroxiredoxin activity.		proteostasis-workbook-2024; proteostasis-ms1
PRDX4		ER proteostasis|Folding enzyme|Peroxiredoxins	ER proteostasis	Folding enzyme	Peroxiredoxins			er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peroxiredoxins	ok_for_propagation_to_go	GO:0051920	peroxiredoxin activity	PRDX1;PRDX3;PRDX4		already_in_goa_exact	GO:0051920 peroxiredoxin activity	This PN group denotes ER peroxiredoxins. The shared molecular function is peroxiredoxin activity.		proteostasis-workbook-2024; proteostasis-ms1
PPIB		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
PPIB		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER cyclophilin-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PPIC		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
PPIC		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER cyclophilin-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
CAMLG		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		new_to_goa		This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
CAMLG		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	Cyclophilin type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG		new_to_goa		This PN type denotes ER cyclophilin-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP2		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP2		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP7		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP7		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP9		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP9		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP10		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP10		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP11		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP11		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP14		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP14		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
FKBP15		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	group	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIB;PPIC;CAMLG;FKBP2;FKBP7		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the ER peptidyl-prolyl isomerase family. The GO PPIase activity term is the appropriate propagation target for this folding enzyme bucket.		proteostasis-workbook-2024; proteostasis-ms1
FKBP15		ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ER proteostasis	Folding enzyme	Peptidyl-prolyl isomerases	FKBP type		er_proteostasis.yaml	type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP2;FKBP7;FKBP9;FKBP10;FKBP11		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN type denotes ER FKBP-family PPIases. The matching GO molecular function is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
P4HA1		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
P4HA2		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
P4HA3		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
P4HB		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
PLOD1		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		already_in_goa_exact	GO:0032964 collagen biosynthetic process	This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
PLOD2		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		already_in_goa_exact	GO:0032964 collagen biosynthetic process	This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
PLOD3		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		already_in_goa_exact	GO:0032964 collagen biosynthetic process	This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
P3H1		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		more_specific_than_existing_goa	GO:0032963 collagen metabolic process	This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
P3H2		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		more_specific_than_existing_goa	GO:0032963 collagen metabolic process	This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
P3H3		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		already_in_goa_exact	GO:0032964 collagen biosynthetic process	This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
COLGALT1		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
COLGALT2		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
CRTAP		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
PGGHG		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
PPIB		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
SERPINH1		ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis	Maturation and folding of specific substrates	ER collagen processing and folding			er_proteostasis.yaml	group	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ok_for_propagation_to_go	GO:0032964	collagen biosynthetic process	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		new_to_goa		This PN group contains ER factors dedicated to collagen maturation, processing, and folding. Collagen biosynthetic process captures the shared substrate-specific pathway context.		proteostasis-workbook-2024; proteostasis-ms1
SEC61A1		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0015031 protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC61A1		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SEC61 channel complex component	ok_for_propagation_to_go	GO:0005784	Sec61 translocon complex	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0005784 Sec61 translocon complex	This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SEC61A2		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0015031 protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC61A2		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SEC61 channel complex component	ok_for_propagation_to_go	GO:0005784	Sec61 translocon complex	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0005784 Sec61 translocon complex	This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SEC61B		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0006886 intracellular protein transport;GO:0030970 retrograde protein transport, ER to cytosol;GO:0031204 post-translational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC61B		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SEC61 channel complex component	ok_for_propagation_to_go	GO:0005784	Sec61 translocon complex	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0005784 Sec61 translocon complex	This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SEC61G		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0015031 protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC61G		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SEC61 channel complex component	ok_for_propagation_to_go	GO:0005784	Sec61 translocon complex	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0005784 Sec61 translocon complex	This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SEC62		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		already_in_goa_exact	GO:0015031 protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC62		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SEC61 channel complex component	ok_for_propagation_to_go	GO:0005784	Sec61 translocon complex	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		more_specific_than_existing_goa	GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005791 rough endoplasmic reticulum;GO:0016020 membrane	This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SEC63		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0031204 post-translational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC63		ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis	Protein transport	SEC61 channel complex component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SEC61 channel complex component	ok_for_propagation_to_go	GO:0005784	Sec61 translocon complex	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		more_specific_than_existing_goa	GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane	This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SRP9		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRP9		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|Signal recognition particle component	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRP9;SRP14;SRP19;SRP54;SRP68		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	This PN group captures core signal-recognition-particle machinery used to direct translating ribosome-nascent chain complexes to the ER membrane. The group is machinery-centric rather than process-equivalent, so it propagates to the GO targeting process.		proteostasis-workbook-2024; proteostasis-ms1
SRP14		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRP14		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|Signal recognition particle component	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRP9;SRP14;SRP19;SRP54;SRP68		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	This PN group captures core signal-recognition-particle machinery used to direct translating ribosome-nascent chain complexes to the ER membrane. The group is machinery-centric rather than process-equivalent, so it propagates to the GO targeting process.		proteostasis-workbook-2024; proteostasis-ms1
SRP19		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRP19		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|Signal recognition particle component	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRP9;SRP14;SRP19;SRP54;SRP68		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	This PN group captures core signal-recognition-particle machinery used to direct translating ribosome-nascent chain complexes to the ER membrane. The group is machinery-centric rather than process-equivalent, so it propagates to the GO targeting process.		proteostasis-workbook-2024; proteostasis-ms1
SRP54		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRP54		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|Signal recognition particle component	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRP9;SRP14;SRP19;SRP54;SRP68		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	This PN group captures core signal-recognition-particle machinery used to direct translating ribosome-nascent chain complexes to the ER membrane. The group is machinery-centric rather than process-equivalent, so it propagates to the GO targeting process.		proteostasis-workbook-2024; proteostasis-ms1
SRP68		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRP68		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|Signal recognition particle component	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRP9;SRP14;SRP19;SRP54;SRP68		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	This PN group captures core signal-recognition-particle machinery used to direct translating ribosome-nascent chain complexes to the ER membrane. The group is machinery-centric rather than process-equivalent, so it propagates to the GO targeting process.		proteostasis-workbook-2024; proteostasis-ms1
SRP72		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRP72		ER proteostasis|Protein transport|Signal recognition particle component	ER proteostasis	Protein transport	Signal recognition particle component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|Signal recognition particle component	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRP9;SRP14;SRP19;SRP54;SRP68		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	This PN group captures core signal-recognition-particle machinery used to direct translating ribosome-nascent chain complexes to the ER membrane. The group is machinery-centric rather than process-equivalent, so it propagates to the GO targeting process.		proteostasis-workbook-2024; proteostasis-ms1
SRPRA		ER proteostasis|Protein transport|SRP receptor subunit	ER proteostasis	Protein transport	SRP receptor subunit			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRPRA		ER proteostasis|Protein transport|SRP receptor subunit	ER proteostasis	Protein transport	SRP receptor subunit			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SRP receptor subunit	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRPRA;SRPRB		already_in_goa_exact	GO:0006614 SRP-dependent cotranslational protein targeting to membrane	SRP receptor subunits participate in docking the SRP-ribosome complex to the ER membrane during cotranslational targeting. Mapping to the GO SRP-dependent targeting process is appropriate at propagation scope.		proteostasis-workbook-2024; proteostasis-ms1
SRPRB		ER proteostasis|Protein transport|SRP receptor subunit	ER proteostasis	Protein transport	SRP receptor subunit			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SRPRB		ER proteostasis|Protein transport|SRP receptor subunit	ER proteostasis	Protein transport	SRP receptor subunit			er_proteostasis.yaml	group	ER proteostasis|Protein transport|SRP receptor subunit	ok_for_propagation_to_go	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	SRPRA;SRPRB		entailed_by_goa_closure	GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	SRP receptor subunits participate in docking the SRP-ribosome complex to the ER membrane during cotranslational targeting. Mapping to the GO SRP-dependent targeting process is appropriate at propagation scope.		proteostasis-workbook-2024; proteostasis-ms1
SSR1		ER proteostasis|Protein transport|TRAP complex component	ER proteostasis	Protein transport	TRAP complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0031204 post-translational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SSR2		ER proteostasis|Protein transport|TRAP complex component	ER proteostasis	Protein transport	TRAP complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0031204 post-translational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SSR3		ER proteostasis|Protein transport|TRAP complex component	ER proteostasis	Protein transport	TRAP complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0031204 post-translational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SSR4		ER proteostasis|Protein transport|TRAP complex component	ER proteostasis	Protein transport	TRAP complex component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0031204 post-translational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TRAM1		ER proteostasis|Protein transport|SEC61 channel accessory protein	ER proteostasis	Protein transport	SEC61 channel accessory protein			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TRAM2		ER proteostasis|Protein transport|SEC61 channel accessory protein	ER proteostasis	Protein transport	SEC61 channel accessory protein			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TRAM1L1		ER proteostasis|Protein transport|SEC61 channel accessory protein	ER proteostasis	Protein transport	SEC61 channel accessory protein			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SERP1		ER proteostasis|Protein transport|SEC61 channel accessory protein	ER proteostasis	Protein transport	SEC61 channel accessory protein			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SERP2		ER proteostasis|Protein transport|SEC61 channel accessory protein	ER proteostasis	Protein transport	SEC61 channel accessory protein			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SPCS1		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SPCS1		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	group	ER proteostasis|Protein transport|ER signal peptidase	ok_for_propagation_to_go	GO:0005787	signal peptidase complex	SPCS1;SPCS2;SPCS3;SEC11A;SEC11C		already_in_goa_exact	GO:0005787 signal peptidase complex	This PN group denotes ER signal peptidase complex components. The matching GO cellular-component term is the direct propagation target.		proteostasis-workbook-2024; proteostasis-ms1
SPCS2		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SPCS2		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	group	ER proteostasis|Protein transport|ER signal peptidase	ok_for_propagation_to_go	GO:0005787	signal peptidase complex	SPCS1;SPCS2;SPCS3;SEC11A;SEC11C		already_in_goa_exact	GO:0005787 signal peptidase complex	This PN group denotes ER signal peptidase complex components. The matching GO cellular-component term is the direct propagation target.		proteostasis-workbook-2024; proteostasis-ms1
SPCS3		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SPCS3		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	group	ER proteostasis|Protein transport|ER signal peptidase	ok_for_propagation_to_go	GO:0005787	signal peptidase complex	SPCS1;SPCS2;SPCS3;SEC11A;SEC11C		already_in_goa_exact	GO:0005787 signal peptidase complex	This PN group denotes ER signal peptidase complex components. The matching GO cellular-component term is the direct propagation target.		proteostasis-workbook-2024; proteostasis-ms1
SEC11A		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC11A		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	group	ER proteostasis|Protein transport|ER signal peptidase	ok_for_propagation_to_go	GO:0005787	signal peptidase complex	SPCS1;SPCS2;SPCS3;SEC11A;SEC11C		already_in_goa_exact	GO:0005787 signal peptidase complex	This PN group denotes ER signal peptidase complex components. The matching GO cellular-component term is the direct propagation target.		proteostasis-workbook-2024; proteostasis-ms1
SEC11C		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC11C		ER proteostasis|Protein transport|ER signal peptidase	ER proteostasis	Protein transport	ER signal peptidase			er_proteostasis.yaml	group	ER proteostasis|Protein transport|ER signal peptidase	ok_for_propagation_to_go	GO:0005787	signal peptidase complex	SPCS1;SPCS2;SPCS3;SEC11A;SEC11C		already_in_goa_exact	GO:0005787 signal peptidase complex	This PN group denotes ER signal peptidase complex components. The matching GO cellular-component term is the direct propagation target.		proteostasis-workbook-2024; proteostasis-ms1
GET1		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
GET1		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		more_specific_than_existing_goa	GO:0090150 establishment of protein localization to membrane	The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
CAMLG		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
CAMLG		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		new_to_goa		The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
GET3		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
GET3		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		new_to_goa		The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
GET4		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
GET4		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		already_in_goa_exact	GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane	The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
SGTA		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SGTA		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		already_in_goa_exact	GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane	The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
SGTB		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SGTB		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		already_in_goa_exact	GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane	The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
BAG6		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		already_in_goa_exact	GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane	The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
UBL4A		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
UBL4A		ER proteostasis|Protein transport|GET pathway component	ER proteostasis	Protein transport	GET pathway component			er_proteostasis.yaml	group	ER proteostasis|Protein transport|GET pathway component	ok_for_propagation_to_go	GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	GET1;CAMLG;GET3;GET4;SGTA		already_in_goa_exact	GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane	The PN GET-pathway group covers machinery for post-translational delivery of tail-anchored membrane proteins to the ER. GO does not model the GET pathway directly in the local cache, and the closest supported process term is post-translational targeting to the ER membrane.		proteostasis-workbook-2024; proteostasis-ms1
TMCO1		ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	ER proteostasis	Protein transport	Transmembrane protein import	GEL complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMCO1		ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	ER proteostasis	Protein transport	Transmembrane protein import	GEL complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
RAB5IF		ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	ER proteostasis	Protein transport	Transmembrane protein import	GEL complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
RAB5IF		ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	ER proteostasis	Protein transport	Transmembrane protein import	GEL complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NCLN		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
NCLN		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TMEM147		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMEM147		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NOMO1		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
NOMO1		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NOMO2		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
NOMO2		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NOMO3		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
NOMO3		ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	ER proteostasis	Protein transport	Transmembrane protein import	BOS complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
CCDC47		ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis	Protein transport	Transmembrane protein import	PAT complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
CCDC47		ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis	Protein transport	Transmembrane protein import	PAT complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
CCDC47		ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis	Protein transport	Transmembrane protein import	PAT complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ok_for_propagation_to_go	GO:0160005	PAT complex	CCDC47;WDR83OS		more_specific_than_existing_goa	GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane	This PN type denotes PAT-complex components in ER membrane protein insertion. The GO PAT complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
WDR83OS		ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis	Protein transport	Transmembrane protein import	PAT complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
WDR83OS		ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis	Protein transport	Transmembrane protein import	PAT complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
WDR83OS		ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis	Protein transport	Transmembrane protein import	PAT complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ok_for_propagation_to_go	GO:0160005	PAT complex	CCDC47;WDR83OS		more_specific_than_existing_goa	GO:0005789 endoplasmic reticulum membrane	This PN type denotes PAT-complex components in ER membrane protein insertion. The GO PAT complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC1		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC1		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC1		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC2		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC2		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC2		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC3		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC3		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC3		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC4		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC4		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC4		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MMGT1		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
MMGT1		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		more_specific_than_existing_goa	GO:0055085 transmembrane transport	This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
MMGT1		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC6		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC6		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC6		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC7		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC7		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC7		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC8		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC8		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC8		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC9		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC9		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC9		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EMC10		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
EMC10		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	group	ER proteostasis|Protein transport|Transmembrane protein import	ok_for_propagation_to_go	GO:0044743	protein transmembrane import into intracellular organelle	TMCO1;RAB5IF;NCLN;TMEM147;NOMO1		new_to_goa		This PN group covers ER transmembrane-protein insertion/import systems such as EMC- and PAT-related pathways. The local GO cache does not expose an ER-specific matching term, so the broader intracellular-organelle transmembrane-import process is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EMC10		ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ER proteostasis	Protein transport	Transmembrane protein import	EMC complex component		er_proteostasis.yaml	type	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	ok_for_propagation_to_go	GO:0072546	EMC complex	EMC1;EMC2;EMC3;EMC4;MMGT1		already_in_goa_exact	GO:0072546 EMC complex	This PN type denotes ER membrane protein complex components. The GO EMC complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
ATP13A1		ER proteostasis|Protein transport|Removal of misinserted transmembrane proteins	ER proteostasis	Protein transport	Removal of misinserted transmembrane proteins			er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC13		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport;GO:0032527 protein exit from endoplasmic reticulum	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC13		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC13		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC31A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		supported_by_goa_regulation	GO:0070863 positive regulation of protein exit from endoplasmic reticulum	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC31A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC31A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC31B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		supported_by_goa_regulation	GO:0070863 positive regulation of protein exit from endoplasmic reticulum	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC31B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC31B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC23A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC23A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC23A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC23B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC23B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC23B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC23IP		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC23IP		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC23IP		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0012507 ER to Golgi transport vesicle membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC24A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC24B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24C		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC24C		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24C		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24D		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SEC24D		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SEC24D		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SAR1A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SAR1A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SAR1A		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SAR1B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0042953 lipoprotein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SAR1B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
SAR1B		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	COPII vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN subtype denotes COPII vesicle coat components. The GO COPII vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
PREB		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|SAR1A/B guanine nucleotide exchange factor	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	SAR1A/B guanine nucleotide exchange factor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0042953 lipoprotein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
PREB		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|SAR1A/B guanine nucleotide exchange factor	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	SAR1A/B guanine nucleotide exchange factor	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport	ok_for_propagation_to_go	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport	This PN type captures anterograde ER-to-Golgi trafficking factors. The GO ER-to-Golgi vesicle-mediated transport process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PREB		ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|SAR1A/B guanine nucleotide exchange factor	ER proteostasis	Protein transport	ER-Golgi trafficking	Anterograde transport	SAR1A/B guanine nucleotide exchange factor	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|SAR1A/B guanine nucleotide exchange factor	ok_for_propagation_to_go	GO:0005085	guanyl-nucleotide exchange factor activity	PREB		already_in_goa_exact	GO:0005085 guanyl-nucleotide exchange factor activity	This PN subtype denotes SAR1 guanine-nucleotide exchange factors in ER export. Guanyl-nucleotide exchange factor activity captures the shared molecular function.		proteostasis-workbook-2024; proteostasis-ms1
COPA		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPA		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPA		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPB1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPB1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPB1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPB2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPB2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPB2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPE		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPE		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPE		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPG1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0009306 protein secretion	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPG1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPG1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPG2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0009306 protein secretion	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPG2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPG2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPZ1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPZ1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPZ1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
COPZ2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
COPZ2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
COPZ2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
ARCN1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
ARCN1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
ARCN1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI vesicle component	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI vesicle components. The GO COPI vesicle coat term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
ARF1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI coating and uncoating	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
ARF1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI coating and uncoating	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		more_specific_than_existing_goa	GO:0016192 vesicle-mediated transport	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
ARF1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI coating and uncoating	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	ARF1;GBF1		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0032991 protein-containing complex	This PN subtype is a COPI coat handling bucket in retrograde ER-Golgi transport. COPI vesicle coat is the appropriate shared cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
GBF1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI coating and uncoating	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
GBF1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI coating and uncoating	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
GBF1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI coating and uncoating	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	ARF1;GBF1		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane	This PN subtype is a COPI coat handling bucket in retrograde ER-Golgi transport. COPI vesicle coat is the appropriate shared cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SCYL1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SCYL1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
SCYL1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	SCYL1;SCYL3;GORAB		already_in_goa_exact	GO:0030126 COPI vesicle coat	This PN subtype denotes COPI coat scaffolding factors. COPI vesicle coat is the appropriate shared cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
SCYL3		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
SCYL3		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		new_to_goa		In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
SCYL3		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	SCYL1;SCYL3;GORAB		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus	This PN subtype denotes COPI coat scaffolding factors. COPI vesicle coat is the appropriate shared cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
GORAB		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
GORAB		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		new_to_goa		In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
GORAB		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	COPI scaffolding in the Golgi	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ok_for_propagation_to_go	GO:0030126	COPI vesicle coat	SCYL1;SCYL3;GORAB		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus	This PN subtype denotes COPI coat scaffolding factors. COPI vesicle coat is the appropriate shared cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
KDELR1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
KDELR1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
KDELR1		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	KDELR1;KDELR2;KDELR3;MYDGF		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	This PN subtype denotes KDEL receptors for Golgi-to-ER retrieval. The matching GO retrograde transport process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
KDELR2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
KDELR2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
KDELR2		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	KDELR1;KDELR2;KDELR3;MYDGF		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	This PN subtype denotes KDEL receptors for Golgi-to-ER retrieval. The matching GO retrograde transport process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
KDELR3		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
KDELR3		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
KDELR3		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	KDELR1;KDELR2;KDELR3;MYDGF		already_in_goa_exact	GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	This PN subtype denotes KDEL receptors for Golgi-to-ER retrieval. The matching GO retrograde transport process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
MYDGF		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		new_to_goa		The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
MYDGF		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	type	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	COPA;COPB1;COPB2;COPE;COPG1		new_to_goa		In `4.3.11`, the earlier retrograde-transport bucket has been folded into ER-Golgi trafficking and now specifically denotes COPI/KDEL-style retrograde trafficking from Golgi back to ER. The correct GO target is therefore retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum rather than ER-to-cytosol retrotranslocation.		proteostasis-workbook-2024; proteostasis-ms1
MYDGF		ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis	Protein transport	ER-Golgi trafficking	Retrograde transport	Receptor for KDEL-containing proteins for retrograde transport	er_proteostasis.yaml	subtype	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ok_for_propagation_to_go	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	KDELR1;KDELR2;KDELR3;MYDGF		new_to_goa		This PN subtype denotes KDEL receptors for Golgi-to-ER retrieval. The matching GO retrograde transport process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TMED1		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED2		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED3		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED4		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED5		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED6		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED7		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED9		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
TMED10		ER proteostasis|Protein transport|ER-Golgi trafficking|Antero- and retrograde transport|Cargo receptor	ER proteostasis	Protein transport	ER-Golgi trafficking	Antero- and retrograde transport	Cargo receptor	er_proteostasis.yaml	class	ER proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0071806 protein transmembrane transport;GO:0106273 cytosol to ERGIC protein transport	The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.	BAG6 is excluded after gene-level review because its GET-pathway placement is already captured by narrower tail-anchored/ER-targeting terms, including post-translational protein targeting to endoplasmic reticulum membrane. Propagating the broad parent protein-transport term would add less precise context rather than a useful new assertion.	proteostasis-workbook-2024; proteostasis-ms1; file:human/BAG6/BAG6-ai-review.yaml; file:human/BAG6/BAG6-notes.md; PMID:20676083; PMID:25535373
DAD1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
DAD1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
DDOST		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
DDOST		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MAGT1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
MAGT1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
OSTC		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
OSTC		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPN1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
RPN1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPN2		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
RPN2		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
STT3A		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
STT3A		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
STT3B		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
STT3B		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TUSC3		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
TUSC3		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
KRTCAP2		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
KRTCAP2		ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ER proteostasis	Glycoproteostasis	N-glycosylation system	Oligosaccharyl transferase complex component		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|N-glycosylation system|Oligosaccharyl transferase complex component	ok_for_propagation_to_go	GO:0008250	oligosaccharyltransferase complex	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0008250 oligosaccharyltransferase complex	This PN type denotes oligosaccharyltransferase complex components. The GO complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MOGS		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Glucose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Glucose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
GANAB		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Glucose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Glucose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		entailed_by_goa_closure	GO:0006491 N-glycan processing	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
PRKCSH		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Glucose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Glucose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		entailed_by_goa_closure	GO:0006491 N-glycan processing	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
MAN1B1		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		entailed_by_goa_closure	GO:0140277 endoplasmic reticulum N-glycan trimming	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
MAN1B1		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	subtype	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ok_for_propagation_to_go	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	MAN1B1;EDEM1;EDEM2;EDEM3		more_specific_than_existing_goa	GO:0009100 glycoprotein metabolic process;GO:0036503 ERAD pathway	Within the ER proteostasis branch, this PN subtype denotes mannose trimming used in glycoprotein quality control and ERAD triage. That is close enough for propagation to the GO mannose-trimming-in-ERAD process, but the PN subtype is framed as a proteostasis step rather than a formal GO process class.		proteostasis-workbook-2024; proteostasis-ms1
EDEM1		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
EDEM1		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	subtype	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ok_for_propagation_to_go	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	MAN1B1;EDEM1;EDEM2;EDEM3		already_in_goa_exact	GO:1904382 mannose trimming involved in glycoprotein ERAD pathway	Within the ER proteostasis branch, this PN subtype denotes mannose trimming used in glycoprotein quality control and ERAD triage. That is close enough for propagation to the GO mannose-trimming-in-ERAD process, but the PN subtype is framed as a proteostasis step rather than a formal GO process class.		proteostasis-workbook-2024; proteostasis-ms1
EDEM2		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		more_specific_than_existing_goa	GO:0009100 glycoprotein metabolic process	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
EDEM2		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	subtype	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ok_for_propagation_to_go	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	MAN1B1;EDEM1;EDEM2;EDEM3		more_specific_than_existing_goa	GO:0009100 glycoprotein metabolic process;GO:0036503 ERAD pathway;GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway	Within the ER proteostasis branch, this PN subtype denotes mannose trimming used in glycoprotein quality control and ERAD triage. That is close enough for propagation to the GO mannose-trimming-in-ERAD process, but the PN subtype is framed as a proteostasis step rather than a formal GO process class.		proteostasis-workbook-2024; proteostasis-ms1
EDEM3		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
EDEM3		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Mannose trimming	er_proteostasis.yaml	subtype	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ok_for_propagation_to_go	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	MAN1B1;EDEM1;EDEM2;EDEM3		already_in_goa_exact	GO:1904382 mannose trimming involved in glycoprotein ERAD pathway	Within the ER proteostasis branch, this PN subtype denotes mannose trimming used in glycoprotein quality control and ERAD triage. That is close enough for propagation to the GO mannose-trimming-in-ERAD process, but the PN subtype is framed as a proteostasis step rather than a formal GO process class.		proteostasis-workbook-2024; proteostasis-ms1
UGGT1		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Re-glucosylation	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Re-glucosylation	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
UGGT2		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Re-glucosylation	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Re-glucosylation	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		already_in_goa_exact	GO:0006487 protein N-linked glycosylation	This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
SELENOF		ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Re-glucosylation	ER proteostasis	Glycoproteostasis	N-glycosylation system	N-glycan processing	Re-glucosylation	er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
MLEC		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
CANX		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
CALR		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
CALR3		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
CLGN		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
LMAN1		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
LMAN1L		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
LMAN2		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
LMAN2L		ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	ER proteostasis	Glycoproteostasis	N-glycosylation system	Lectin chaperone		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|N-glycosylation system	ok_for_propagation_to_go	GO:0006487	protein N-linked glycosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		new_to_goa		This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms1
POMT1		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|O-glycosylation system	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		already_in_goa_exact	GO:0006493 protein O-linked glycosylation	This PN group captures ER O-glycosylation machinery. Protein O-linked glycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
POMT1		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		already_in_goa_exact	GO:0006493 protein O-linked glycosylation	This PN type captures ER O-mannosylation machinery. Current GO support is best represented by the broader protein O-linked glycosylation process.		proteostasis-workbook-2024; proteostasis-ms1
POMT2		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|O-glycosylation system	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		already_in_goa_exact	GO:0006493 protein O-linked glycosylation	This PN group captures ER O-glycosylation machinery. Protein O-linked glycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
POMT2		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		already_in_goa_exact	GO:0006493 protein O-linked glycosylation	This PN type captures ER O-mannosylation machinery. Current GO support is best represented by the broader protein O-linked glycosylation process.		proteostasis-workbook-2024; proteostasis-ms1
TMTC1		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|O-glycosylation system	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN group captures ER O-glycosylation machinery. Protein O-linked glycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TMTC1		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN type captures ER O-mannosylation machinery. Current GO support is best represented by the broader protein O-linked glycosylation process.		proteostasis-workbook-2024; proteostasis-ms1
TMTC2		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|O-glycosylation system	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN group captures ER O-glycosylation machinery. Protein O-linked glycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TMTC2		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN type captures ER O-mannosylation machinery. Current GO support is best represented by the broader protein O-linked glycosylation process.		proteostasis-workbook-2024; proteostasis-ms1
TMTC3		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|O-glycosylation system	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN group captures ER O-glycosylation machinery. Protein O-linked glycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TMTC3		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN type captures ER O-mannosylation machinery. Current GO support is best represented by the broader protein O-linked glycosylation process.		proteostasis-workbook-2024; proteostasis-ms1
TMTC4		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	group	ER proteostasis|Glycoproteostasis|O-glycosylation system	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN group captures ER O-glycosylation machinery. Protein O-linked glycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TMTC4		ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ER proteostasis	Glycoproteostasis	O-glycosylation system	O-mannosylation		er_proteostasis.yaml	type	ER proteostasis|Glycoproteostasis|O-glycosylation system|O-mannosylation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	POMT1;POMT2;TMTC1;TMTC2;TMTC3		entailed_by_goa_closure	GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0035269 protein O-linked glycosylation via mannose	This PN type captures ER O-mannosylation machinery. Current GO support is best represented by the broader protein O-linked glycosylation process.		proteostasis-workbook-2024; proteostasis-ms1
SYVN1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
DERL1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
DERL2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
DERL3		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
HERPUD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
HERPUD2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
BCAP31		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		more_specific_than_existing_goa	GO:0034976 response to endoplasmic reticulum stress	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
FAM8A1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
SEL1L		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
SEL1L2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE2J1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
FAF2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
AUP1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
OS9		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
ERLEC1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Retrotranslocation channel complex		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
VCP		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
VCP		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
UBXN8		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBXN8		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
UBXN4		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBXN4		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
UBQLN1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBQLN1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
UBQLN2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBQLN2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
UFD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UFD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
NPLOC4		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
NPLOC4		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
SELENOS		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
SELENOS		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
AMFR		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
AMFR		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|VCP accessories	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	VCP accessories	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
RHBDD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RHBDD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
RHBDD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ok_for_propagation_to_go	GO:0004252	serine-type endopeptidase activity	RHBDD1;RHBDD2;RHBDL3		already_in_goa_exact	GO:0004252 serine-type endopeptidase activity	This PN subtype is represented by rhomboid-family intramembrane proteases. Serine-type endopeptidase activity is the shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RHBDD2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RHBDD2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
RHBDD2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ok_for_propagation_to_go	GO:0004252	serine-type endopeptidase activity	RHBDD1;RHBDD2;RHBDL3		already_in_goa_exact	GO:0004252 serine-type endopeptidase activity	This PN subtype is represented by rhomboid-family intramembrane proteases. Serine-type endopeptidase activity is the shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RHBDL3		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RHBDL3		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ok_for_propagation_to_go	GO:0036503	ERAD pathway	VCP;UBXN8;UBXN4;UBQLN1;UBQLN2		new_to_goa		This PN type captures the VCP/p97-dependent retrotranslocation machinery used in ERAD. It is not a separate process from ERAD, but a core mechanistic subsystem within it.		proteostasis-workbook-2024; proteostasis-ms1
RHBDL3		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	VCP system for retrotranslocation in ERAD	Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	ok_for_propagation_to_go	GO:0004252	serine-type endopeptidase activity	RHBDD1;RHBDD2;RHBDL3		already_in_goa_exact	GO:0004252 serine-type endopeptidase activity	This PN subtype is represented by rhomboid-family intramembrane proteases. Serine-type endopeptidase activity is the shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
ERLIN1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
ERLIN1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	ERLIN1;ERLIN2;TMUB1;JKAMP;SVIP		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures ER-lumenal and membrane-local ERAD handling steps prior to retrotranslocation. These steps are mechanistic parts of the broader ERAD pathway, so propagation to ERAD pathway is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
ERLIN2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
ERLIN2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	ERLIN1;ERLIN2;TMUB1;JKAMP;SVIP		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures ER-lumenal and membrane-local ERAD handling steps prior to retrotranslocation. These steps are mechanistic parts of the broader ERAD pathway, so propagation to ERAD pathway is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
TMUB1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
TMUB1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	ERLIN1;ERLIN2;TMUB1;JKAMP;SVIP		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures ER-lumenal and membrane-local ERAD handling steps prior to retrotranslocation. These steps are mechanistic parts of the broader ERAD pathway, so propagation to ERAD pathway is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
JKAMP		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
JKAMP		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	ERLIN1;ERLIN2;TMUB1;JKAMP;SVIP		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type captures ER-lumenal and membrane-local ERAD handling steps prior to retrotranslocation. These steps are mechanistic parts of the broader ERAD pathway, so propagation to ERAD pathway is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
SVIP		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		supported_by_goa_regulation	GO:1904293 negative regulation of ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
SVIP		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	ER handling of ERAD substrates		er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	ERLIN1;ERLIN2;TMUB1;JKAMP;SVIP		supported_by_goa_regulation	GO:1904293 negative regulation of ERAD pathway	This PN type captures ER-lumenal and membrane-local ERAD handling steps prior to retrotranslocation. These steps are mechanistic parts of the broader ERAD pathway, so propagation to ERAD pathway is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
UBE2K		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE2K		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
UBE2K		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN subtype denotes ERAD-associated E2 enzymes. Ubiquitin conjugating enzyme activity is the appropriate shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
UBE2D1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE2D1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
UBE2D1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN subtype denotes ERAD-associated E2 enzymes. Ubiquitin conjugating enzyme activity is the appropriate shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
UBE2J2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE2J2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
UBE2J2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN subtype denotes ERAD-associated E2 enzymes. Ubiquitin conjugating enzyme activity is the appropriate shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
UBE2G1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE2G1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
UBE2G1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN subtype denotes ERAD-associated E2 enzymes. Ubiquitin conjugating enzyme activity is the appropriate shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
UBE2G2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE2G2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
UBE2G2		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated E2 conjugating enzyme	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN subtype denotes ERAD-associated E2 enzymes. Ubiquitin conjugating enzyme activity is the appropriate shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
RNFT1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		supported_by_goa_regulation	GO:1904294 positive regulation of ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNFT1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		supported_by_goa_regulation	GO:1904294 positive regulation of ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNFT1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RNF103		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNF103		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNF103		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RNF139		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNF139		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNF139		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RNF145		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNF145		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNF145		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RNF170		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNF170		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNF170		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RNF5		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNF5		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNF5		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
RNF185		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
RNF185		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
RNF185		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
MARCHF6		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
MARCHF6		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
MARCHF6		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
TRIM13		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
TRIM13		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
TRIM13		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
TRIM25		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
TRIM25		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
TRIM25		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated RING E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNFT1;RNF103;RNF139;RNF145;RNF170		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated RING E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
UBE4B		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated UBOX E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated UBOX E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
UBE4B		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated UBOX E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated UBOX E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
UBE4B		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated UBOX E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated UBOX E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated UBOX E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE4B		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated U-box E3 ligases. Ubiquitin protein ligase activity is the appropriate shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
TMEM129		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated idiosyncratic E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated idiosyncratic E3 ligase	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
TMEM129		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated idiosyncratic E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated idiosyncratic E3 ligase	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
TMEM129		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated idiosyncratic E3 ligase	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated idiosyncratic E3 ligase	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated idiosyncratic E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TMEM129		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN subtype denotes ERAD-associated E3 ligases with noncanonical architecture. Ubiquitin protein ligase activity is the shared catalytic target.		proteostasis-workbook-2024; proteostasis-ms1
OTUB1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
OTUB1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
OTUB1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	OTUB1;YOD1;USP14;USP19		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN subtype denotes ERAD-associated deubiquitinases. Deubiquitinase activity captures the shared molecular function.		proteostasis-workbook-2024; proteostasis-ms1
YOD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
YOD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
YOD1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	OTUB1;YOD1;USP14;USP19		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN subtype denotes ERAD-associated deubiquitinases. Deubiquitinase activity captures the shared molecular function.		proteostasis-workbook-2024; proteostasis-ms1
USP14		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		supported_by_goa_regulation	GO:1904293 negative regulation of ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
USP14		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		supported_by_goa_regulation	GO:1904293 negative regulation of ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
USP14		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	OTUB1;YOD1;USP14;USP19		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN subtype denotes ERAD-associated deubiquitinases. Deubiquitinase activity captures the shared molecular function.		proteostasis-workbook-2024; proteostasis-ms1
USP19		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
USP19		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
USP19		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated DUB	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	OTUB1;YOD1;USP14;USP19		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN subtype denotes ERAD-associated deubiquitinases. Deubiquitinase activity captures the shared molecular function.		proteostasis-workbook-2024; proteostasis-ms1
TMEM67		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated UPS component	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated UPS component	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		already_in_goa_exact	GO:0036503 ERAD pathway	"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
TMEM67		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated UPS component	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	ERAD-associated UPS component	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		already_in_goa_exact	GO:0036503 ERAD pathway	This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
NGLY1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
NGLY1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
NGLY1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ok_for_propagation_to_go	GO:0006517	protein deglycosylation	NGLY1;ENGASE;MAN2C1		new_to_goa		This PN subtype denotes cytosolic deglycosylation of ERAD substrates. Protein deglycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
ENGASE		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
ENGASE		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
ENGASE		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ok_for_propagation_to_go	GO:0006517	protein deglycosylation	NGLY1;ENGASE;MAN2C1		new_to_goa		This PN subtype denotes cytosolic deglycosylation of ERAD substrates. Protein deglycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MAN2C1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	group	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	exact	GO:0036503	ERAD pathway	SYVN1;DERL1;DERL2;DERL3;HERPUD1		new_to_goa		"The PN group ""ER associated degradation"" is a direct lexical and biological match to the GO ERAD pathway term. The additional branch and class context disambiguates the source string from any broader degradation language."	This starter mapping targets the generic ERAD pathway term rather than more specific glycoprotein-ERAD descendants.	proteostasis-workbook-2024
MAN2C1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	type	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ok_for_propagation_to_go	GO:0036503	ERAD pathway	UBE2K;UBE2D1;UBE2J2;UBE2G1;UBE2G2		new_to_goa		This PN type covers the cytosolic processing steps that receive ERAD substrates after retrotranslocation. These activities remain part of the ERAD pathway, but the source category is a specific mechanistic slice.		proteostasis-workbook-2024; proteostasis-ms1
MAN2C1		ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis	Organelle-specific protein degradation	ER associated degradation	Cytosolic handling of ERAD substrates	Deglycosylation of ERAD substrates	er_proteostasis.yaml	subtype	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ok_for_propagation_to_go	GO:0006517	protein deglycosylation	NGLY1;ENGASE;MAN2C1		new_to_goa		This PN subtype denotes cytosolic deglycosylation of ERAD substrates. Protein deglycosylation is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
HSPA9		Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70	Mitochondrial proteostasis	Chaperone	HSP70 system	HSP70		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPA9		more_specific_than_existing_goa	GO:0006457 protein folding;GO:0044183 protein folding chaperone	In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class.	Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping.	proteostasis-workbook-2024
DNAJA3		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		already_in_goa_exact	GO:0030544 Hsp70 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC4		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC11		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC15		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC19		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
HSCB		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0003674 molecular_function;GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC30		Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis	Chaperone	HSP70 system	J-domain containing HSP70 cochaperone		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ok_for_propagation_to_go	GO:0030544	Hsp70 protein binding	DNAJA3;HSCB;DNAJB1;DNAJB6		more_specific_than_existing_goa	GO:0005515 protein binding	In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.		proteostasis-workbook-2024; proteostasis-ms1
GRPEL1		Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|GRPE subtype	Mitochondrial proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	GRPE subtype	chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GRPEL1		Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|GRPE subtype	Mitochondrial proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	GRPE subtype	mitochondrial_proteostasis.yaml	subtype	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|GRPE subtype	ok_for_propagation_to_go	GO:0001405	PAM complex, Tim23 associated import motor	GRPEL1;GRPEL2		already_in_goa_exact	GO:0001405 PAM complex, Tim23 associated import motor	This mitochondrial GRPE subtype is represented by GRPEL1/GRPEL2, PAM import-motor nucleotide-exchange factors. The GO PAM complex term is the direct complex-membership target.		proteostasis-workbook-2024; proteostasis-ms1
GRPEL2		Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|GRPE subtype	Mitochondrial proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	GRPE subtype	chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor	ok_for_propagation_to_go	GO:0000774	adenyl-nucleotide exchange factor activity	GRPEL1;GRPEL2;BAG1;HSPBP1		already_in_goa_exact	GO:0000774 adenyl-nucleotide exchange factor activity	These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GRPEL2		Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|GRPE subtype	Mitochondrial proteostasis	Chaperone	HSP70 system	HSP70 nucleotide exchange factor	GRPE subtype	mitochondrial_proteostasis.yaml	subtype	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|GRPE subtype	ok_for_propagation_to_go	GO:0001405	PAM complex, Tim23 associated import motor	GRPEL1;GRPEL2		already_in_goa_exact	GO:0001405 PAM complex, Tim23 associated import motor	This mitochondrial GRPE subtype is represented by GRPEL1/GRPEL2, PAM import-motor nucleotide-exchange factors. The GO PAM complex term is the direct complex-membership target.		proteostasis-workbook-2024; proteostasis-ms1
HSPD1		Mitochondrial proteostasis|Chaperone|HSP60 system|HSP60	Mitochondrial proteostasis	Chaperone	HSP60 system	HSP60		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Chaperone|HSP60 system|HSP60	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	HSPD1		already_in_goa_exact	GO:0140662 ATP-dependent protein folding chaperone	The mitochondrial HSP60 PN category corresponds to canonical chaperonins that carry out ATP-dependent protein folding. The source label denotes the family/system member type rather than the GO molecular-function class itself, so propagation scope is the better fit.		proteostasis-workbook-2024; proteostasis-ms1
HSPE1		Mitochondrial proteostasis|Chaperone|HSP60 system|HSP10	Mitochondrial proteostasis	Chaperone	HSP60 system	HSP10		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Chaperone|HSP60 system|HSP10	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPE1;HSPE1-MOB4		already_in_goa_exact	GO:0044183 protein folding chaperone	This PN type denotes mitochondrial HSP10/HSPE co-chaperonins. The shared GO function is protein folding chaperone.		proteostasis-workbook-2024; proteostasis-ms1
HSPE1-MOB4		Mitochondrial proteostasis|Chaperone|HSP60 system|HSP10	Mitochondrial proteostasis	Chaperone	HSP60 system	HSP10		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Chaperone|HSP60 system|HSP10	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPE1;HSPE1-MOB4		no_local_goa		This PN type denotes mitochondrial HSP10/HSPE co-chaperonins. The shared GO function is protein folding chaperone.		proteostasis-workbook-2024; proteostasis-ms1
TRAP1		Mitochondrial proteostasis|Chaperone|HSP90 system|HSP90	Mitochondrial proteostasis	Chaperone	HSP90 system	HSP90		chaperone_systems.yaml	type	Mitochondrial proteostasis|Chaperone|HSP90 system|HSP90	ok_for_propagation_to_go	GO:0140662	ATP-dependent protein folding chaperone	TRAP1		already_in_goa_exact	GO:0140662 ATP-dependent protein folding chaperone	In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class.	This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts.	proteostasis-workbook-2024
HSPB1		Mitochondrial proteostasis|Chaperone|small HSP	Mitochondrial proteostasis	Chaperone	small HSP			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;CRYAB;HSPB8		already_in_goa_exact	GO:0044183 protein folding chaperone	This PN group denotes mitochondrial small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB2		Mitochondrial proteostasis|Chaperone|small HSP	Mitochondrial proteostasis	Chaperone	small HSP			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;CRYAB;HSPB8		new_to_goa		This PN group denotes mitochondrial small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB3		Mitochondrial proteostasis|Chaperone|small HSP	Mitochondrial proteostasis	Chaperone	small HSP			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;CRYAB;HSPB8		new_to_goa		This PN group denotes mitochondrial small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
CRYAB		Mitochondrial proteostasis|Chaperone|small HSP	Mitochondrial proteostasis	Chaperone	small HSP			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;CRYAB;HSPB8		more_specific_than_existing_goa	GO:0006457 protein folding	This PN group denotes mitochondrial small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
HSPB8		Mitochondrial proteostasis|Chaperone|small HSP	Mitochondrial proteostasis	Chaperone	small HSP			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|small HSP	ok_for_propagation_to_go	GO:0044183	protein folding chaperone	HSPB1;HSPB2;HSPB3;CRYAB;HSPB8		new_to_goa		This PN group denotes mitochondrial small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term.		proteostasis-workbook-2024; proteostasis-ms1
CLPB		Mitochondrial proteostasis|Chaperone|HSP100 disaggregase	Mitochondrial proteostasis	Chaperone	HSP100 disaggregase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|HSP100 disaggregase	ok_for_propagation_to_go	GO:0140545	ATP-dependent protein disaggregase activity	CLPB		already_in_goa_exact	GO:0140545 ATP-dependent protein disaggregase activity	This PN group denotes mitochondrial HSP100/LON-family disaggregase activity. The GO ATP-dependent protein disaggregase activity term is the closest molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM8A		Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	Mitochondrial proteostasis	Chaperone	Small intermembrane space chaperone			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	ok_for_propagation_to_go	GO:0042719	mitochondrial intermembrane space chaperone complex	TIMM8A;TIMM8B;TIMM9;TIMM10;TIMM10B		already_in_goa_exact	GO:0042719 mitochondrial intermembrane space chaperone complex	This PN group captures the small intermembrane-space chaperone system that stabilizes imported proteins in the mitochondrial intermembrane space. The GO cellular-component term for the mitochondrial intermembrane space chaperone complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM8B		Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	Mitochondrial proteostasis	Chaperone	Small intermembrane space chaperone			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	ok_for_propagation_to_go	GO:0042719	mitochondrial intermembrane space chaperone complex	TIMM8A;TIMM8B;TIMM9;TIMM10;TIMM10B		already_in_goa_exact	GO:0042719 mitochondrial intermembrane space chaperone complex	This PN group captures the small intermembrane-space chaperone system that stabilizes imported proteins in the mitochondrial intermembrane space. The GO cellular-component term for the mitochondrial intermembrane space chaperone complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM9		Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	Mitochondrial proteostasis	Chaperone	Small intermembrane space chaperone			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	ok_for_propagation_to_go	GO:0042719	mitochondrial intermembrane space chaperone complex	TIMM8A;TIMM8B;TIMM9;TIMM10;TIMM10B		already_in_goa_exact	GO:0042719 mitochondrial intermembrane space chaperone complex	This PN group captures the small intermembrane-space chaperone system that stabilizes imported proteins in the mitochondrial intermembrane space. The GO cellular-component term for the mitochondrial intermembrane space chaperone complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM10		Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	Mitochondrial proteostasis	Chaperone	Small intermembrane space chaperone			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	ok_for_propagation_to_go	GO:0042719	mitochondrial intermembrane space chaperone complex	TIMM8A;TIMM8B;TIMM9;TIMM10;TIMM10B		already_in_goa_exact	GO:0042719 mitochondrial intermembrane space chaperone complex	This PN group captures the small intermembrane-space chaperone system that stabilizes imported proteins in the mitochondrial intermembrane space. The GO cellular-component term for the mitochondrial intermembrane space chaperone complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM10B		Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	Mitochondrial proteostasis	Chaperone	Small intermembrane space chaperone			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	ok_for_propagation_to_go	GO:0042719	mitochondrial intermembrane space chaperone complex	TIMM8A;TIMM8B;TIMM9;TIMM10;TIMM10B		already_in_goa_exact	GO:0042719 mitochondrial intermembrane space chaperone complex	This PN group captures the small intermembrane-space chaperone system that stabilizes imported proteins in the mitochondrial intermembrane space. The GO cellular-component term for the mitochondrial intermembrane space chaperone complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM13		Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	Mitochondrial proteostasis	Chaperone	Small intermembrane space chaperone			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Chaperone|Small intermembrane space chaperone	ok_for_propagation_to_go	GO:0042719	mitochondrial intermembrane space chaperone complex	TIMM8A;TIMM8B;TIMM9;TIMM10;TIMM10B		already_in_goa_exact	GO:0042719 mitochondrial intermembrane space chaperone complex	This PN group captures the small intermembrane-space chaperone system that stabilizes imported proteins in the mitochondrial intermembrane space. The GO cellular-component term for the mitochondrial intermembrane space chaperone complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
CHCHD4		Mitochondrial proteostasis|Folding enzyme|Protein disulfide isomerases	Mitochondrial proteostasis	Folding enzyme	Protein disulfide isomerases			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0160203	mitochondrial disulfide relay system	CHCHD4;GFER		already_in_goa_exact	GO:0160203 mitochondrial disulfide relay system	This PN group contains CHCHD4/GFER mitochondrial disulfide-relay factors. The GO mitochondrial disulfide relay system process captures the shared mitochondrial folding chemistry better than a generic PDI label.		proteostasis-workbook-2024; proteostasis-ms1
GFER		Mitochondrial proteostasis|Folding enzyme|Protein disulfide isomerases	Mitochondrial proteostasis	Folding enzyme	Protein disulfide isomerases			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Folding enzyme|Protein disulfide isomerases	ok_for_propagation_to_go	GO:0160203	mitochondrial disulfide relay system	CHCHD4;GFER		already_in_goa_exact	GO:0160203 mitochondrial disulfide relay system	This PN group contains CHCHD4/GFER mitochondrial disulfide-relay factors. The GO mitochondrial disulfide relay system process captures the shared mitochondrial folding chemistry better than a generic PDI label.		proteostasis-workbook-2024; proteostasis-ms1
PPIF		Mitochondrial proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	Mitochondrial proteostasis	Folding enzyme	Peptidyl-prolyl isomerases			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Folding enzyme|Peptidyl-prolyl isomerases	ok_for_propagation_to_go	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PPIF		already_in_goa_exact	GO:0003755 peptidyl-prolyl cis-trans isomerase activity	This PN group is the mitochondrial peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
SAMM50		Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	Mitochondrial proteostasis	Membrane protein folding	Sorting and assembly machinery outer membrane			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	ok_for_propagation_to_go	GO:0005741	mitochondrial outer membrane	SAMM50;MTX1;MTX2;MTX3		already_in_goa_exact	GO:0005741 mitochondrial outer membrane	This PN group denotes the SAM outer-membrane assembly system. The GO mitochondrial outer membrane cellular-component term is a conservative propagation target for this assembly-focused bucket.		proteostasis-workbook-2024; proteostasis-ms1
MTX1		Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	Mitochondrial proteostasis	Membrane protein folding	Sorting and assembly machinery outer membrane			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	ok_for_propagation_to_go	GO:0005741	mitochondrial outer membrane	SAMM50;MTX1;MTX2;MTX3		already_in_goa_exact	GO:0005741 mitochondrial outer membrane	This PN group denotes the SAM outer-membrane assembly system. The GO mitochondrial outer membrane cellular-component term is a conservative propagation target for this assembly-focused bucket.		proteostasis-workbook-2024; proteostasis-ms1
MTX2		Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	Mitochondrial proteostasis	Membrane protein folding	Sorting and assembly machinery outer membrane			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	ok_for_propagation_to_go	GO:0005741	mitochondrial outer membrane	SAMM50;MTX1;MTX2;MTX3		already_in_goa_exact	GO:0005741 mitochondrial outer membrane	This PN group denotes the SAM outer-membrane assembly system. The GO mitochondrial outer membrane cellular-component term is a conservative propagation target for this assembly-focused bucket.		proteostasis-workbook-2024; proteostasis-ms1
MTX3		Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	Mitochondrial proteostasis	Membrane protein folding	Sorting and assembly machinery outer membrane			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|Sorting and assembly machinery outer membrane	ok_for_propagation_to_go	GO:0005741	mitochondrial outer membrane	SAMM50;MTX1;MTX2;MTX3		already_in_goa_exact	GO:0005741 mitochondrial outer membrane	This PN group denotes the SAM outer-membrane assembly system. The GO mitochondrial outer membrane cellular-component term is a conservative propagation target for this assembly-focused bucket.		proteostasis-workbook-2024; proteostasis-ms1
MTCH1		Mitochondrial proteostasis|Membrane protein folding|Insertase for helical proteins into the outer membrane	Mitochondrial proteostasis	Membrane protein folding	Insertase for helical proteins into the outer membrane			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|Insertase for helical proteins into the outer membrane	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	MTCH1;MTCH2		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the machinery that inserts helical membrane proteins into the mitochondrial outer membrane. The corresponding GO process term protein insertion into mitochondrial outer membrane is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
MTCH2		Mitochondrial proteostasis|Membrane protein folding|Insertase for helical proteins into the outer membrane	Mitochondrial proteostasis	Membrane protein folding	Insertase for helical proteins into the outer membrane			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|Insertase for helical proteins into the outer membrane	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	MTCH1;MTCH2		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the machinery that inserts helical membrane proteins into the mitochondrial outer membrane. The corresponding GO process term protein insertion into mitochondrial outer membrane is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
IMMT		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
CHCHD6		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
CHCHD3		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MICOS13		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
APOO		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
APOOL		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
CHCHD4		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MICOS10		Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis	Membrane protein folding	MICOS complex			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	ok_for_propagation_to_go	GO:0061617	MICOS complex	IMMT;CHCHD6;CHCHD3;MICOS13;APOO		already_in_goa_exact	GO:0061617 MICOS complex	This PN group denotes MICOS-complex components. The GO MICOS complex cellular-component term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM5		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		new_to_goa		The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM5		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM5		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM6		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		new_to_goa		The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM6		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM6		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM7		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM7		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM7		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM20		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM20		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM20		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM20L		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM20L		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		new_to_goa		This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM20L		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM22		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM22		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM22		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM40		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM40		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM40		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM40L		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM40L		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		more_specific_than_existing_goa	GO:0008150 biological_process	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM40L		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TOMM70		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TOMM70		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Outer membrane import	ok_for_propagation_to_go	GO:0045040	protein insertion into mitochondrial outer membrane	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0045040 protein insertion into mitochondrial outer membrane	This PN group covers the outer-membrane entry route for mitochondrial protein import. The matching GO process protein insertion into mitochondrial outer membrane is the best conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TOMM70		Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	Mitochondrial proteostasis	Protein transport	Outer membrane import	TOMM complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	ok_for_propagation_to_go	GO:0005742	mitochondrial outer membrane translocase complex	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		already_in_goa_exact	GO:0005742 mitochondrial outer membrane translocase complex	This PN subtype denotes TOMM-complex component membership for outer- membrane import. The source is a component-role category that maps naturally to the GO cellular-component term for the mitochondrial outer membrane translocase complex.		proteostasis-workbook-2024; proteostasis-ms1
TIMM17A		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM17A		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM17B		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM17B		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM21		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM21		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM23		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM23		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM23B		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0008320 transmembrane protein transporter activity;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM23B		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM44		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM44		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM50		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM50		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
PAM16		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
PAM16		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM17/23 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM17/23 complex	ok_for_propagation_to_go	GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	TIMM17A;TIMM17B;TIMM21;TIMM23;TIMM23B		already_in_goa_exact	GO:0005744 TIM23 mitochondrial import inner membrane translocase complex	This PN type denotes TIMM17/23 import-complex components. The GO TIM23 mitochondrial import inner membrane translocase complex term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM22		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM22 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		entailed_by_goa_closure	GO:0008320 transmembrane protein transporter activity;GO:0071806 protein transmembrane transport	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM22		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM22 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	ok_for_propagation_to_go	GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	TIMM22;TIMM29;AGK		already_in_goa_exact	GO:0042721 TIM22 mitochondrial import inner membrane insertion complex	This PN type captures TIMM22-complex components responsible for a specific inner-membrane import route. The GO cellular-component term for the TIM22 insertion complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
TIMM29		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM22 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		new_to_goa		The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
TIMM29		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM22 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	ok_for_propagation_to_go	GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	TIMM22;TIMM29;AGK		already_in_goa_exact	GO:0042721 TIM22 mitochondrial import inner membrane insertion complex	This PN type captures TIMM22-complex components responsible for a specific inner-membrane import route. The GO cellular-component term for the TIM22 insertion complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
AGK		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM22 complex		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		new_to_goa		The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
AGK		Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	Mitochondrial proteostasis	Protein transport	Inner membrane import	TIMM22 complex		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	ok_for_propagation_to_go	GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	TIMM22;TIMM29;AGK		already_in_goa_exact	GO:0042721 TIM22 mitochondrial import inner membrane insertion complex	This PN type captures TIMM22-complex components responsible for a specific inner-membrane import route. The GO cellular-component term for the TIM22 insertion complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
OXA1L		Mitochondrial proteostasis|Protein transport|Inner membrane import|For assembly of inner membrane complexes	Mitochondrial proteostasis	Protein transport	Inner membrane import	For assembly of inner membrane complexes		mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		new_to_goa		The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
OXA1L		Mitochondrial proteostasis|Protein transport|Inner membrane import|For assembly of inner membrane complexes	Mitochondrial proteostasis	Protein transport	Inner membrane import	For assembly of inner membrane complexes		mitochondrial_proteostasis.yaml	type	Mitochondrial proteostasis|Protein transport|Inner membrane import|For assembly of inner membrane complexes	ok_for_propagation_to_go	GO:0032977	membrane insertase activity	OXA1L		already_in_goa_exact	GO:0032977 membrane insertase activity	This PN leaf is represented by OXA1L, the mitochondrial inner-membrane insertase for assembly of membrane complexes. Membrane insertase activity is the best-supported molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
YWHAZ		Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	Mitochondrial proteostasis	Protein transport	Cytosolic mitochondria import stimulation factor			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		more_specific_than_existing_goa	GO:0008104 intracellular protein localization	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
YWHAZ		Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	Mitochondrial proteostasis	Protein transport	Cytosolic mitochondria import stimulation factor			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	ok_for_propagation_to_go	GO:0015031	protein transport	YWHAZ;YWHAE		more_specific_than_existing_goa	GO:0008104 intracellular protein localization	This PN group captures cytosolic factors that stimulate mitochondrial import before TOM/TIM route commitment. The source is broader than a specific matrix-import pathway, so the conservative propagation target is GO protein transport.		proteostasis-workbook-2024; proteostasis-ms1
YWHAE		Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	Mitochondrial proteostasis	Protein transport	Cytosolic mitochondria import stimulation factor			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	TOMM5;TOMM6;TOMM7;TOMM20;TOMM20L		more_specific_than_existing_goa	GO:0008104 intracellular protein localization	The PN mitochondrial Protein transport class groups protein-targeting and import pathways into mitochondria. GO protein transport is the appropriate propagation target, while the source class remains mitochondria-specific and broader than any single GO transport subtype.		proteostasis-workbook-2024; proteostasis-ms1
YWHAE		Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	Mitochondrial proteostasis	Protein transport	Cytosolic mitochondria import stimulation factor			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	ok_for_propagation_to_go	GO:0015031	protein transport	YWHAZ;YWHAE		more_specific_than_existing_goa	GO:0008104 intracellular protein localization	This PN group captures cytosolic factors that stimulate mitochondrial import before TOM/TIM route commitment. The source is broader than a specific matrix-import pathway, so the conservative propagation target is GO protein transport.		proteostasis-workbook-2024; proteostasis-ms1
MIPEP		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis;GO:0016485 protein processing	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
MIPEP		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
METAP1D		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
METAP1D		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
XPNPEP3		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis;GO:0016485 protein processing	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
XPNPEP3		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005739 mitochondrion	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
IMMP1L		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis;GO:0016485 protein processing	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
IMMP1L		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
IMMP2L		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis;GO:0016485 protein processing	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
IMMP2L		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
PMPCA		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis;GO:0016485 protein processing	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
PMPCA		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		already_in_goa_exact	GO:0017087 mitochondrial processing peptidase complex	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
PMPCB		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		more_specific_than_existing_goa	GO:0006508 proteolysis;GO:0016485 protein processing	This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
PMPCB		Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis	Mitochondrial protein maturation	Processing peptidase			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	ok_for_propagation_to_go	GO:0017087	mitochondrial processing peptidase complex	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		already_in_goa_exact	GO:0017087 mitochondrial processing peptidase complex	This PN group captures the mitochondrial processing peptidase machinery that removes targeting presequences from imported mitochondrial proteins. The GO cellular-component term for the mitochondrial processing peptidase complex is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms1
PDF		Mitochondrial proteostasis|Mitochondrial protein maturation|Methionine deformylation	Mitochondrial proteostasis	Mitochondrial protein maturation	Methionine deformylation			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Mitochondrial protein maturation	ok_for_propagation_to_go	GO:0034982	mitochondrial protein processing	MIPEP;METAP1D;XPNPEP3;IMMP1L;IMMP2L		new_to_goa		This PN class groups maturation steps for mitochondrial proteins. The GO mitochondrial protein processing term captures the shared process-level semantics.		proteostasis-workbook-2024; proteostasis-ms1
PDF		Mitochondrial proteostasis|Mitochondrial protein maturation|Methionine deformylation	Mitochondrial proteostasis	Mitochondrial protein maturation	Methionine deformylation			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Mitochondrial protein maturation|Methionine deformylation	ok_for_propagation_to_go	GO:0042586	peptide deformylase activity	PDF		already_in_goa_exact	GO:0042586 peptide deformylase activity	This PN group captures mitochondrial N-terminal methionine deformylation. The shared catalytic activity is peptide deformylase activity.		proteostasis-workbook-2024; proteostasis-ms1
VCP		Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	Mitochondrial proteostasis	Organelle-specific protein degradation	mitoTAD pathway			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
MARCHF5		Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	Mitochondrial proteostasis	Organelle-specific protein degradation	mitoTAD pathway			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
USP30		Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	Mitochondrial proteostasis	Organelle-specific protein degradation	mitoTAD pathway			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
FAF2		Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	Mitochondrial proteostasis	Organelle-specific protein degradation	mitoTAD pathway			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
ANKZF1		Mitochondrial proteostasis|Organelle-specific protein degradation|Vms pathway	Mitochondrial proteostasis	Organelle-specific protein degradation	Vms pathway			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
ATAD1		Mitochondrial proteostasis|Organelle-specific protein degradation|mitoCPR pathway	Mitochondrial proteostasis	Organelle-specific protein degradation	mitoCPR pathway			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
UBQLN1		Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	Mitochondrial proteostasis	Organelle-specific protein degradation	Degradation of mitochondrial membrane proteins that fail targeting			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
UBQLN2		Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	Mitochondrial proteostasis	Organelle-specific protein degradation	Degradation of mitochondrial membrane proteins that fail targeting			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
UBQLN3		Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	Mitochondrial proteostasis	Organelle-specific protein degradation	Degradation of mitochondrial membrane proteins that fail targeting			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
UBQLN4		Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	Mitochondrial proteostasis	Organelle-specific protein degradation	Degradation of mitochondrial membrane proteins that fail targeting			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
UBQLNL		Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	Mitochondrial proteostasis	Organelle-specific protein degradation	Degradation of mitochondrial membrane proteins that fail targeting			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
NLN		Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Intermembrane space protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
NLN		Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Intermembrane space protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	ok_for_propagation_to_go	GO:0005758	mitochondrial intermembrane space	NLN;ATP23;HTRA2		already_in_goa_exact	GO:0005758 mitochondrial intermembrane space	This PN group captures proteases assigned specifically to the mitochondrial intermembrane space. The source bucket is compartmental and mechanistic rather than a single shared enzymatic GO class, so the mitochondrial intermembrane space cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
ATP23		Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Intermembrane space protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
ATP23		Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Intermembrane space protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	ok_for_propagation_to_go	GO:0005758	mitochondrial intermembrane space	NLN;ATP23;HTRA2		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group captures proteases assigned specifically to the mitochondrial intermembrane space. The source bucket is compartmental and mechanistic rather than a single shared enzymatic GO class, so the mitochondrial intermembrane space cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
HTRA2		Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Intermembrane space protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		already_in_goa_exact	GO:0035694 mitochondrial protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
HTRA2		Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Intermembrane space protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	ok_for_propagation_to_go	GO:0005758	mitochondrial intermembrane space	NLN;ATP23;HTRA2		already_in_goa_exact	GO:0005758 mitochondrial intermembrane space	This PN group captures proteases assigned specifically to the mitochondrial intermembrane space. The source bucket is compartmental and mechanistic rather than a single shared enzymatic GO class, so the mitochondrial intermembrane space cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
PITRM1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		more_specific_than_existing_goa	GO:0030163 protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
PITRM1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		already_in_goa_exact	GO:0005759 mitochondrial matrix	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
YME1L1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		already_in_goa_exact	GO:0035694 mitochondrial protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
YME1L1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
SPG7		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		more_specific_than_existing_goa	GO:0007005 mitochondrion organization	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
SPG7		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
AFG3L2		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		more_specific_than_existing_goa	GO:0030163 protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
AFG3L2		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
CLPX		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		more_specific_than_existing_goa	GO:0030163 protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
CLPX		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		already_in_goa_exact	GO:0005759 mitochondrial matrix	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
CLPP		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		already_in_goa_exact	GO:0035694 mitochondrial protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
CLPP		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		already_in_goa_exact	GO:0005759 mitochondrial matrix	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
LONP1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		already_in_goa_exact	GO:0035694 mitochondrial protein catabolic process	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
LONP1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		already_in_goa_exact	GO:0005759 mitochondrial matrix	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
PARK7		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		more_specific_than_existing_goa	GO:0007005 mitochondrion organization	This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
PARK7		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		already_in_goa_exact	GO:0005759 mitochondrial matrix	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
OMA1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	class	Mitochondrial proteostasis|Organelle-specific protein degradation	ok_for_propagation_to_go	GO:0035694	mitochondrial protein catabolic process	VCP;MARCHF5;USP30;FAF2;ANKZF1		new_to_goa		This PN class groups mitochondrial protein-degradation pathways. GO mitochondrial protein catabolic process is the conservative shared target.		proteostasis-workbook-2024; proteostasis-ms1
OMA1		Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis	Organelle-specific protein degradation	Matrix protease			mitochondrial_proteostasis.yaml	group	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ok_for_propagation_to_go	GO:0005759	mitochondrial matrix	PITRM1;YME1L1;SPG7;AFG3L2;CLPX		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group identifies matrix-local protease systems. The source is a compartmental proteostasis bucket, so the mitochondrial matrix cellular-component term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
ASF1A		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		already_in_goa_exact	GO:0140713 histone chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
ASF1B		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		already_in_goa_exact	GO:0140713 histone chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
MCM2		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
TONSL		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
RBBP7		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
IPO4		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NASP		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
HAT1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
SPTY2D1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		already_in_goa_exact	GO:0140713 histone chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
SUPT6H		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
ANP32E		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		already_in_goa_exact	GO:0140713 histone chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
VPS72		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		already_in_goa_exact	GO:0140713 histone chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
HJURP		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
SET		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NAP1L1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		already_in_goa_exact	GO:0140713 histone chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NAP1L2		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NAP1L3		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NAP1L4		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NAP1L5		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NPM1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NPM2		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NPM3		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
NCL		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
CHAF1A		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
CHAF1B		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
RBBP4		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
HIRA		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
UBN1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
CABIN1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
SUPT16H		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		entailed_by_goa_closure	GO:0000511 H2A-H2B histone complex chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
SSRP1		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
DAXX		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		entailed_by_goa_closure	GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity	This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
ATRX		Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis	Chaperone	Histone chaperone			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Chaperone|Histone chaperone	ok_for_propagation_to_go	GO:0140713	histone chaperone activity	ASF1A;ASF1B;NPM1;CHAF1A		new_to_goa		This PN group collects nuclear histone-chaperone factors involved in histone handling, deposition, or exchange. The PN bucket is narrower than general nuclear proteostasis and aligns well with the GO molecular function histone chaperone activity.		proteostasis-workbook-2024; proteostasis-ms1
GLE1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
GLE1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP214		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP214		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
RANBP2		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANBP2		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP88		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP88		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
RAE1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RAE1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP42		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP42		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP37		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP37		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP43		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP43		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP85		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP85		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
SEC13		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport;GO:0032527 protein exit from endoplasmic reticulum	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
SEC13		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP98		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP98		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP107		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP107		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP133		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP133		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP160		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP160		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
SEH1L		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
SEH1L		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
AHCTF1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
AHCTF1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP155		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP155		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP188		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP188		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP205		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP205		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP35		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP35		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP93		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP93		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP54		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP54		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP58		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		supported_by_goa_regulation	GO:0042306 regulation of protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP58		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP62		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP62		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP62CL		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP62CL		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NDC1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0015031 protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NDC1		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP210		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP210		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
POM121		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
POM121		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
POM121C		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
POM121C		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
POM121L2		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
POM121L2		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
POM121L12		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		no_local_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
POM121L12		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		no_local_goa		This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
AAAS		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
AAAS		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP153		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP153		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
NUP50		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
NUP50		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
TPR		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
TPR		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
DDX19B		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
DDX19B		Nuclear proteostasis|Protein transport|Nuclear pore complex	Nuclear proteostasis	Protein transport	Nuclear pore complex			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear pore complex	ok_for_propagation_to_go	GO:0005643	nuclear pore	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0005643 nuclear pore	This PN group denotes core components of the nuclear pore complex. The closest current GO target in the local ontology cache is the cellular-component term nuclear pore.		proteostasis-workbook-2024; proteostasis-ms1
KPNB1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNB1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006404 RNA import into nucleus;GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNB1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006404 RNA import into nucleus;GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
TNPO1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
TNPO1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
TNPO1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
TNPO2		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
TNPO2		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
TNPO2		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0006610 ribosomal protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO8		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO8		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO8		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO9		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO9		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO9		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO11		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO11		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO11		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
TNPO3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
TNPO3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
TNPO3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
XPO1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
CSE1L		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
CSE1L		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006611 protein export from nucleus	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
CSE1L		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006611 protein export from nucleus	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
XPO5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006405 RNA export from nucleus;GO:0006611 protein export from nucleus;GO:0035281 pre-miRNA export from nucleus	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006405 RNA export from nucleus;GO:0006611 protein export from nucleus;GO:0035281 pre-miRNA export from nucleus	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
XPO6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006611 protein export from nucleus	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006611 protein export from nucleus	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
XPO7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPOT		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
XPOT		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPOT		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP17		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANBP17		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP17		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO13		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
IPO13		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
IPO13		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
XPO4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006611 protein export from nucleus	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
XPO4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0005049 nuclear export signal receptor activity;GO:0006611 protein export from nucleus	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANBP6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, beta type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, beta type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;TNPO1;TNPO2;IPO4;IPO5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-beta family members are the closest thing in this PN branch to a transport-receptor activity class, but the current validated GO cache does not expose a clean family-level importin/exportin receptor MF term for this mapping set. The source type is therefore propagated to the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA1		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
KPNA2		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA2		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA2		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
KPNA3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
KPNA4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA4		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
KPNA5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA5		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
KPNA6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA6		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
KPNA7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
KPNA7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
KPNA7		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Importin, alpha type		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Importin, alpha type	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNA1;KPNA2;KPNA3;KPNA4;KPNA5		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006607 NLS-bearing protein import into nucleus;GO:0061608 nuclear import signal receptor activity	Importin-alpha factors are primarily cargo-recognition adaptors that bind NLS-containing cargo and work with karyopherin-beta transport receptors, rather than forming a clean standalone GO receptor-activity class in the local ontology. The PN type is therefore better propagated to the process nucleocytoplasmic transport than forced into an MF mapping.		proteostasis-workbook-2024; proteostasis-ms1
SNUPN		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
SNUPN		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006404 RNA import into nucleus;GO:0006606 protein import into nucleus;GO:0061015 snRNA import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
SNUPN		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	SNUPN;HEATR3;HIKESHI		entailed_by_goa_closure	GO:0006404 RNA import into nucleus;GO:0006606 protein import into nucleus;GO:0061015 snRNA import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN type groups dedicated nuclear-transport factors outside the canonical importin-alpha/importin-beta classes, including factors such as SNUPN and HIKESHI. Because this is a mixed mechanistic bucket rather than a single shared molecular activity, propagation to nucleocytoplasmic transport is the appropriate level.		proteostasis-workbook-2024; proteostasis-ms1
HEATR3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
HEATR3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
HEATR3		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	SNUPN;HEATR3;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus	This PN type groups dedicated nuclear-transport factors outside the canonical importin-alpha/importin-beta classes, including factors such as SNUPN and HIKESHI. Because this is a mixed mechanistic bucket rather than a single shared molecular activity, propagation to nucleocytoplasmic transport is the appropriate level.		proteostasis-workbook-2024; proteostasis-ms1
HIKESHI		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		already_in_goa_exact	GO:0015031 protein transport	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
HIKESHI		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	KPNB1;KPNA2;XPO1;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN group is not a clean molecular-function class. In the workbook it includes canonical karyopherin-beta transport receptors, importin-alpha cargo-recognition adaptors, and other dedicated nuclear-transport factors such as SNUPN and HIKESHI. The shared biology is participation in receptor-mediated traffic through the nuclear pore, not a single GO receptor-activity term, so the defensible target is the broader process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
HIKESHI		Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	Nuclear proteostasis	Protein transport	Nuclear transport receptor	Non-importin transport receptor		nuclear_proteostasis.yaml	type	Nuclear proteostasis|Protein transport|Nuclear transport receptor|Non-importin transport receptor	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	SNUPN;HEATR3;HIKESHI		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0061608 nuclear import signal receptor activity	This PN type groups dedicated nuclear-transport factors outside the canonical importin-alpha/importin-beta classes, including factors such as SNUPN and HIKESHI. Because this is a mixed mechanistic bucket rather than a single shared molecular activity, propagation to nucleocytoplasmic transport is the appropriate level.		proteostasis-workbook-2024; proteostasis-ms1
RAN		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006606 protein import into nucleus;GO:0006611 protein export from nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RAN		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANGAP1		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		supported_by_goa_regulation	GO:0046826 negative regulation of protein export from nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANGAP1		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP2		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANBP2		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		already_in_goa_exact	GO:0006913 nucleocytoplasmic transport	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD1		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD1		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD2		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD2		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD3		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD3		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD4		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD4		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD5		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD5		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD6		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD6		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RGPD8		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RGPD8		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006607 NLS-bearing protein import into nucleus;GO:0051168 nuclear export	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RCC1		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RCC1		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		new_to_goa		The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RCC1L		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		new_to_goa		The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RCC1L		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		new_to_goa		The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP3		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANBP3		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006611 protein export from nucleus	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
RANBP3L		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	class	Nuclear proteostasis|Protein transport	ok_for_propagation_to_go	GO:0015031	protein transport	GLE1;NUP214;RANBP2;NUP88;RAE1		entailed_by_goa_closure	GO:0006611 protein export from nucleus	The PN nuclear Protein transport class covers the machinery and routes that move proteins across the nuclear envelope. GO protein transport is the correct propagation target, although the PN class is specialized to the nuclear compartment.		proteostasis-workbook-2024; proteostasis-ms1
RANBP3L		Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis	Protein transport	Nuclear transport, RAN system			nuclear_proteostasis.yaml	group	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	ok_for_propagation_to_go	GO:0006913	nucleocytoplasmic transport	RAN;RANGAP1;RANBP2;RGPD1;RGPD2		entailed_by_goa_closure	GO:0006611 protein export from nucleus	The PN Ran-system group captures the directionality and cargo-release machinery that powers nuclear import and export. This is a mechanistic subsystem within the broader GO process nucleocytoplasmic transport.		proteostasis-workbook-2024; proteostasis-ms1
HIF1A		PN regulation|Transcription factor|Hypoxic stress response|Transcription of hypoxic stress response genes	PN regulation	Transcription factor	Hypoxic stress response	Transcription of hypoxic stress response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
HIF1A		PN regulation|Transcription factor|Hypoxic stress response|Transcription of hypoxic stress response genes	PN regulation	Transcription factor	Hypoxic stress response	Transcription of hypoxic stress response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Hypoxic stress response	ok_for_propagation_to_go	GO:0071456	cellular response to hypoxia	HIF1A		already_in_goa_exact	GO:0071456 cellular response to hypoxia	The PN group contains hypoxia-response transcription factors such as HIF1A. Cellular response to hypoxia is the matching process-level target for this branch.		proteostasis-workbook-2024; proteostasis-ms1
HIF1A		PN regulation|Transcription factor|Hypoxic stress response|Transcription of hypoxic stress response genes	PN regulation	Transcription factor	Hypoxic stress response	Transcription of hypoxic stress response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Hypoxic stress response|Transcription of hypoxic stress response genes	ok_for_propagation_to_go	GO:0071456	cellular response to hypoxia	HIF1A		already_in_goa_exact	GO:0071456 cellular response to hypoxia	This leaf captures HIF-mediated hypoxic transcriptional response. The shared GO process target is cellular response to hypoxia.		proteostasis-workbook-2024; proteostasis-ms1
HSF1		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
HSF1		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Heat shock response	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0034605 cellular response to heat	The PN group contains heat-shock transcription factors. Propagation to cellular response to heat captures the shared response program without asserting a specific target-gene set.		proteostasis-workbook-2024; proteostasis-ms1
HSF1		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0034605 cellular response to heat	This leaf captures HSF-mediated heat-shock transcriptional response. The shared GO process target is cellular response to heat.		proteostasis-workbook-2024; proteostasis-ms1
HSF2		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
HSF2		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Heat shock response	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		new_to_goa		The PN group contains heat-shock transcription factors. Propagation to cellular response to heat captures the shared response program without asserting a specific target-gene set.		proteostasis-workbook-2024; proteostasis-ms1
HSF2		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		new_to_goa		This leaf captures HSF-mediated heat-shock transcriptional response. The shared GO process target is cellular response to heat.		proteostasis-workbook-2024; proteostasis-ms1
HSF4		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
HSF4		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Heat shock response	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		new_to_goa		The PN group contains heat-shock transcription factors. Propagation to cellular response to heat captures the shared response program without asserting a specific target-gene set.		proteostasis-workbook-2024; proteostasis-ms1
HSF4		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		new_to_goa		This leaf captures HSF-mediated heat-shock transcriptional response. The shared GO process target is cellular response to heat.		proteostasis-workbook-2024; proteostasis-ms1
HSF5		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
HSF5		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Heat shock response	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		new_to_goa		The PN group contains heat-shock transcription factors. Propagation to cellular response to heat captures the shared response program without asserting a specific target-gene set.		proteostasis-workbook-2024; proteostasis-ms1
HSF5		PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation	Transcription factor	Heat shock response	Transcription of heat shock response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	ok_for_propagation_to_go	GO:0034605	cellular response to heat	HSF1;HSF2;HSF4;HSF5		new_to_goa		This leaf captures HSF-mediated heat-shock transcriptional response. The shared GO process target is cellular response to heat.		proteostasis-workbook-2024; proteostasis-ms1
ATF3		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
ATF3		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	ATF3;ATF4;DDIT3		new_to_goa		This PN path groups transcription factors that execute the transcriptional arm of the integrated stress response. The source category is a regulator subclass within the signaling program, so propagation to the GO ISR signaling term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
ATF3		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	ATF3;ATF4;DDIT3		new_to_goa		This leaf denotes transcriptional execution of the integrated stress response. The existing ISR signaling mapping is appropriate at this narrower level as well.		proteostasis-workbook-2024; proteostasis-ms1
ATF4		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
ATF4		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	ATF3;ATF4;DDIT3		already_in_goa_exact	GO:0140467 integrated stress response signaling	This PN path groups transcription factors that execute the transcriptional arm of the integrated stress response. The source category is a regulator subclass within the signaling program, so propagation to the GO ISR signaling term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
ATF4		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	ATF3;ATF4;DDIT3		already_in_goa_exact	GO:0140467 integrated stress response signaling	This leaf denotes transcriptional execution of the integrated stress response. The existing ISR signaling mapping is appropriate at this narrower level as well.		proteostasis-workbook-2024; proteostasis-ms1
DDIT3		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
DDIT3		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	ATF3;ATF4;DDIT3		already_in_goa_exact	GO:0140467 integrated stress response signaling	This PN path groups transcription factors that execute the transcriptional arm of the integrated stress response. The source category is a regulator subclass within the signaling program, so propagation to the GO ISR signaling term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
DDIT3		PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation	Transcription factor	Integrated stress response	Transcription of integrated stress response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	ATF3;ATF4;DDIT3		already_in_goa_exact	GO:0140467 integrated stress response signaling	This leaf denotes transcriptional execution of the integrated stress response. The existing ISR signaling mapping is appropriate at this narrower level as well.		proteostasis-workbook-2024; proteostasis-ms1
NFKB1		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NFKB1		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	group	PN regulation|Transcription factor|Inflammatory response	ok_for_propagation_to_go	GO:0006954	inflammatory response	NFKB1;NFKB2;REL;RELA;RELB		already_in_goa_exact	GO:0006954 inflammatory response	This PN group captures transcription factors assigned to inflammatory response signaling as a proteostasis-regulatory context. The source is a context-defined regulator bucket rather than an exact GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
NFKB1		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	subtype	PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		entailed_by_goa_closure	GO:0035525 NF-kappaB p50/p65 complex	This subtype consists of NF-kappaB transcription-factor complex components. The GO cellular-component term NF-kappaB complex is a direct, defensible propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NFKB2		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NFKB2		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	group	PN regulation|Transcription factor|Inflammatory response	ok_for_propagation_to_go	GO:0006954	inflammatory response	NFKB1;NFKB2;REL;RELA;RELB		new_to_goa		This PN group captures transcription factors assigned to inflammatory response signaling as a proteostasis-regulatory context. The source is a context-defined regulator bucket rather than an exact GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
NFKB2		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	subtype	PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		more_specific_than_existing_goa	GO:0005634 nucleus	This subtype consists of NF-kappaB transcription-factor complex components. The GO cellular-component term NF-kappaB complex is a direct, defensible propagation target.		proteostasis-workbook-2024; proteostasis-ms1
REL		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
REL		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	group	PN regulation|Transcription factor|Inflammatory response	ok_for_propagation_to_go	GO:0006954	inflammatory response	NFKB1;NFKB2;REL;RELA;RELB		already_in_goa_exact	GO:0006954 inflammatory response	This PN group captures transcription factors assigned to inflammatory response signaling as a proteostasis-regulatory context. The source is a context-defined regulator bucket rather than an exact GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
REL		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	subtype	PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		more_specific_than_existing_goa	GO:0005634 nucleus	This subtype consists of NF-kappaB transcription-factor complex components. The GO cellular-component term NF-kappaB complex is a direct, defensible propagation target.		proteostasis-workbook-2024; proteostasis-ms1
RELA		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
RELA		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	group	PN regulation|Transcription factor|Inflammatory response	ok_for_propagation_to_go	GO:0006954	inflammatory response	NFKB1;NFKB2;REL;RELA;RELB		already_in_goa_exact	GO:0006954 inflammatory response	This PN group captures transcription factors assigned to inflammatory response signaling as a proteostasis-regulatory context. The source is a context-defined regulator bucket rather than an exact GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
RELA		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	subtype	PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		already_in_goa_exact	GO:0071159 NF-kappaB complex	This subtype consists of NF-kappaB transcription-factor complex components. The GO cellular-component term NF-kappaB complex is a direct, defensible propagation target.		proteostasis-workbook-2024; proteostasis-ms1
RELB		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
RELB		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	group	PN regulation|Transcription factor|Inflammatory response	ok_for_propagation_to_go	GO:0006954	inflammatory response	NFKB1;NFKB2;REL;RELA;RELB		already_in_goa_exact	GO:0006954 inflammatory response	This PN group captures transcription factors assigned to inflammatory response signaling as a proteostasis-regulatory context. The source is a context-defined regulator bucket rather than an exact GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
RELB		PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	PN regulation	Transcription factor	Inflammatory response	Transcription of xenobiotic response genes	NFkB complex component	pn_regulation.yaml	subtype	PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		more_specific_than_existing_goa	GO:0005634 nucleus;GO:0032991 protein-containing complex	This subtype consists of NF-kappaB transcription-factor complex components. The GO cellular-component term NF-kappaB complex is a direct, defensible propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NFE2L2		PN regulation|Transcription factor|Oxidative stress response|Transcription of oxidative response genes	PN regulation	Transcription factor	Oxidative stress response	Transcription of oxidative response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NFE2L2		PN regulation|Transcription factor|Oxidative stress response|Transcription of oxidative response genes	PN regulation	Transcription factor	Oxidative stress response	Transcription of oxidative response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Oxidative stress response	ok_for_propagation_to_go	GO:1900407	regulation of cellular response to oxidative stress	NFE2L2		already_in_goa_exact	GO:1900407 regulation of cellular response to oxidative stress	This PN group captures transcription factors assigned to oxidative-stress response programs. Those factors regulate the oxidative-stress response, so the GO regulation term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
NFE2L2		PN regulation|Transcription factor|Oxidative stress response|Transcription of oxidative response genes	PN regulation	Transcription factor	Oxidative stress response	Transcription of oxidative response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Oxidative stress response|Transcription of oxidative response genes	ok_for_propagation_to_go	GO:1900407	regulation of cellular response to oxidative stress	NFE2L2		already_in_goa_exact	GO:1900407 regulation of cellular response to oxidative stress	This PN type names the transcriptional arm of the oxidative-stress response. Mapping to regulation of cellular response to oxidative stress preserves the process-level meaning without overclaiming exactness.		proteostasis-workbook-2024; proteostasis-ms1
NFE2L1		PN regulation|Transcription factor|Proteasome recovery pathway|Transcription of proteasome genes	PN regulation	Transcription factor	Proteasome recovery pathway	Transcription of proteasome genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
ATF6		PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	PN regulation	Transcription factor	Unfolded protein response	Transcription of unfolded protein response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
ATF6		PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	PN regulation	Transcription factor	Unfolded protein response	Transcription of unfolded protein response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Unfolded protein response	ok_for_propagation_to_go	GO:0030968	endoplasmic reticulum unfolded protein response	ATF6;XBP1		already_in_goa_exact	GO:0030968 endoplasmic reticulum unfolded protein response	The PN group contains transcription factors that execute ER unfolded-protein-response programs. The GO ER unfolded protein response term is the conservative process target.		proteostasis-workbook-2024; proteostasis-ms1
ATF6		PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	PN regulation	Transcription factor	Unfolded protein response	Transcription of unfolded protein response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	ok_for_propagation_to_go	GO:0006986	response to unfolded protein	ATF6;XBP1		entailed_by_goa_closure	GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036500 ATF6-mediated unfolded protein response	This PN type captures transcriptional outputs of the unfolded-protein response. The broader GO response-to-unfolded-protein process is a conservative propagation target for this label.		proteostasis-workbook-2024; proteostasis-ms1
XBP1		PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	PN regulation	Transcription factor	Unfolded protein response	Transcription of unfolded protein response genes		pn_regulation.yaml	class	PN regulation|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A;HSF1;HSF2;HSF4;HSF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This PN class is the transcription-factor branch of proteostasis regulation. Current members converge on DNA-binding transcription-factor activity, making this an appropriate class-level propagation target.		proteostasis-workbook-2024; proteostasis-ms1
XBP1		PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	PN regulation	Transcription factor	Unfolded protein response	Transcription of unfolded protein response genes		pn_regulation.yaml	group	PN regulation|Transcription factor|Unfolded protein response	ok_for_propagation_to_go	GO:0030968	endoplasmic reticulum unfolded protein response	ATF6;XBP1		already_in_goa_exact	GO:0030968 endoplasmic reticulum unfolded protein response	The PN group contains transcription factors that execute ER unfolded-protein-response programs. The GO ER unfolded protein response term is the conservative process target.		proteostasis-workbook-2024; proteostasis-ms1
XBP1		PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	PN regulation	Transcription factor	Unfolded protein response	Transcription of unfolded protein response genes		pn_regulation.yaml	type	PN regulation|Transcription factor|Unfolded protein response|Transcription of unfolded protein response genes	ok_for_propagation_to_go	GO:0006986	response to unfolded protein	ATF6;XBP1		entailed_by_goa_closure	GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036498 IRE1-mediated unfolded protein response;GO:0036500 ATF6-mediated unfolded protein response	This PN type captures transcriptional outputs of the unfolded-protein response. The broader GO response-to-unfolded-protein process is a conservative propagation target for this label.		proteostasis-workbook-2024; proteostasis-ms1
TRIB3		PN regulation|Transcription factor regulator|Inflammatory response|NFkB modulator	PN regulation	Transcription factor regulator	Inflammatory response	NFkB modulator		pn_regulation.yaml	group	PN regulation|Transcription factor regulator|Inflammatory response	ok_for_propagation_to_go	GO:0006954	inflammatory response	TRIB3		new_to_goa		This PN group captures transcription-factor regulators assigned to inflammatory-response control. Propagation to inflammatory response keeps the source-side process context while remaining conservative about exact equivalence.		proteostasis-workbook-2024; proteostasis-ms1
KEAP1		PN regulation|Transcription factor regulator|Oxidative stress response|NFE2L2 modulator	PN regulation	Transcription factor regulator	Oxidative stress response	NFE2L2 modulator		pn_regulation.yaml	group	PN regulation|Transcription factor regulator|Oxidative stress response	ok_for_propagation_to_go	GO:1900407	regulation of cellular response to oxidative stress	KEAP1		new_to_goa		This PN group captures regulators of oxidative-stress-responsive transcription factors. Propagation to regulation of cellular response to oxidative stress preserves the intended process context.		proteostasis-workbook-2024; proteostasis-ms1
KEAP1		PN regulation|Transcription factor regulator|Oxidative stress response|NFE2L2 modulator	PN regulation	Transcription factor regulator	Oxidative stress response	NFE2L2 modulator		pn_regulation.yaml	type	PN regulation|Transcription factor regulator|Oxidative stress response|NFE2L2 modulator	ok_for_propagation_to_go	GO:0006979	response to oxidative stress	KEAP1		entailed_by_goa_closure	GO:0034599 cellular response to oxidative stress	NFE2L2 modulators are upstream regulators of the oxidative-stress response program. GO response to oxidative stress is the conservative propagation target here.		proteostasis-workbook-2024; proteostasis-ms1
ERN1		PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator	PN regulation	Transcription factor regulator	Unfolded protein response	XBP1 modulator		pn_regulation.yaml	group	PN regulation|Transcription factor regulator|Unfolded protein response	ok_for_propagation_to_go	GO:0030968	endoplasmic reticulum unfolded protein response	ERN1		already_in_goa_exact	GO:0030968 endoplasmic reticulum unfolded protein response	This regulator bucket is represented by ERN1/IRE1 signaling in the PN taxonomy. The broader ER unfolded protein response term is the appropriate propagation target for the source label.		proteostasis-workbook-2024; proteostasis-ms1
ERN1		PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator	PN regulation	Transcription factor regulator	Unfolded protein response	XBP1 modulator		pn_regulation.yaml	type	PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator	ok_for_propagation_to_go	GO:1903894	regulation of IRE1-mediated unfolded protein response	ERN1		new_to_goa		In `4.3.11`, XBP1 modulators are classified under transcription-factor regulators rather than translation regulators. They remain direct participants in IRE1-mediated unfolded protein response control, so the same GO regulation term is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK1		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		already_in_goa_exact	GO:0006417 regulation of translation	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK1		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		already_in_goa_exact	GO:0140467 integrated stress response signaling	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK1		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:0032055	negative regulation of translation in response to stress	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4		more_specific_than_existing_goa	GO:0006417 regulation of translation;GO:0006950 response to stress	EIF2S1 phosphorylation is the canonical mechanism that suppresses global translation during the integrated stress response. The GO term negative regulation of translation in response to stress is therefore an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK2		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0006446 regulation of translational initiation;GO:0017148 negative regulation of translation;GO:2000766 negative regulation of cytoplasmic translation	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK2		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		new_to_goa		This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK2		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:0032055	negative regulation of translation in response to stress	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4		more_specific_than_existing_goa	GO:0017148 negative regulation of translation	EIF2S1 phosphorylation is the canonical mechanism that suppresses global translation during the integrated stress response. The GO term negative regulation of translation in response to stress is therefore an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK3		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0006446 regulation of translational initiation;GO:0017148 negative regulation of translation;GO:0032055 negative regulation of translation in response to stress;GO:0032057 negative regulation of translational initiation in response to stress;GO:0036491 regulation of translation initiation in response to endoplasmic reticulum stress;GO:0045182 translation regulator activity;GO:0045947 negative regulation of translational initiation	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK3		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0036499 PERK-mediated unfolded protein response	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK3		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:0032055	negative regulation of translation in response to stress	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4		already_in_goa_exact	GO:0032055 negative regulation of translation in response to stress	EIF2S1 phosphorylation is the canonical mechanism that suppresses global translation during the integrated stress response. The GO term negative regulation of translation in response to stress is therefore an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK4		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0006446 regulation of translational initiation;GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation;GO:0032057 negative regulation of translational initiation in response to stress;GO:0045947 negative regulation of translational initiation;GO:0071264 positive regulation of translational initiation in response to starvation	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK4		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0140469 GCN2-mediated signaling	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK4		PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:0032055	negative regulation of translation in response to stress	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4		new_to_goa		EIF2S1 phosphorylation is the canonical mechanism that suppresses global translation during the integrated stress response. The GO term negative regulation of translation in response to stress is therefore an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
PPP1R15A		PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Dephosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0006446 regulation of translational initiation;GO:0032058 positive regulation of translational initiation in response to stress;GO:0036490 regulation of translation in response to endoplasmic reticulum stress;GO:0043558 regulation of translational initiation in response to stress	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
PPP1R15A		PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Dephosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		supported_by_goa_regulation	GO:1903898 negative regulation of PERK-mediated unfolded protein response	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
PPP1R15A		PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Dephosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:0032055	negative regulation of translation in response to stress	PPP1R15A;PPP1R15B		more_specific_than_existing_goa	GO:0051246 regulation of protein metabolic process	EIF2S1 dephosphorylation resets the integrated stress response machinery that had imposed stress-responsive translational repression. The PN type remains part of this translation-regulatory stress module and can propagate to the same GO stress-translation term.		proteostasis-workbook-2024; proteostasis-ms1
PPP1R15B		PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Dephosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		more_specific_than_existing_goa	GO:0051246 regulation of protein metabolic process	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
PPP1R15B		PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Dephosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		supported_by_goa_regulation	GO:1903898 negative regulation of PERK-mediated unfolded protein response	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
PPP1R15B		PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Integrated stress response	Dephosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:0032055	negative regulation of translation in response to stress	PPP1R15A;PPP1R15B		more_specific_than_existing_goa	GO:0051246 regulation of protein metabolic process	EIF2S1 dephosphorylation resets the integrated stress response machinery that had imposed stress-responsive translational repression. The PN type remains part of this translation-regulatory stress module and can propagate to the same GO stress-translation term.		proteostasis-workbook-2024; proteostasis-ms1
DELE1		PN regulation|Translation regulator|Integrated stress response|EIF2AK1 modulator	PN regulation	Translation regulator	Integrated stress response	EIF2AK1 modulator		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		new_to_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
DELE1		PN regulation|Translation regulator|Integrated stress response|EIF2AK1 modulator	PN regulation	Translation regulator	Integrated stress response	EIF2AK1 modulator		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		already_in_goa_exact	GO:0140467 integrated stress response signaling	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
GCN1		PN regulation|Translation regulator|Integrated stress response|EIF2AK4 modulator	PN regulation	Translation regulator	Integrated stress response	EIF2AK4 modulator		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		already_in_goa_exact	GO:0006417 regulation of translation	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
GCN1		PN regulation|Translation regulator|Integrated stress response|EIF2AK4 modulator	PN regulation	Translation regulator	Integrated stress response	EIF2AK4 modulator		pn_regulation.yaml	group	PN regulation|Translation regulator|Integrated stress response	ok_for_propagation_to_go	GO:0140467	integrated stress response signaling	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0140469 GCN2-mediated signaling	This PN path covers translation-regulator components of the integrated stress response, including EIF2S1 phosphorylation control. These genes are participants in integrated stress response signaling, but the PN group is a mechanistic slice of the process rather than a GO-equivalent class.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK3		PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Unfolded protein response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		entailed_by_goa_closure	GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0006446 regulation of translational initiation;GO:0017148 negative regulation of translation;GO:0032055 negative regulation of translation in response to stress;GO:0032057 negative regulation of translational initiation in response to stress;GO:0036491 regulation of translation initiation in response to endoplasmic reticulum stress;GO:0045182 translation regulator activity;GO:0045947 negative regulation of translational initiation	This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK3		PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Unfolded protein response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	group	PN regulation|Translation regulator|Unfolded protein response	ok_for_propagation_to_go	GO:1903894	regulation of IRE1-mediated unfolded protein response	EIF2AK3		new_to_goa		This PN group marks the translational control arm of the unfolded protein response. Regulation of IRE1-mediated unfolded protein response is the cleanest propagation target in the local GO cache.		proteostasis-workbook-2024; proteostasis-ms1
EIF2AK3		PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation	Translation regulator	Unfolded protein response	Phosphorylation of EIF2alpha/EIF2S1		pn_regulation.yaml	type	PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1	ok_for_propagation_to_go	GO:1903894	regulation of IRE1-mediated unfolded protein response	EIF2AK3		new_to_goa		This PN type links eIF2alpha phosphorylation to unfolded-protein-response control. The exact GO response-to-unfolded-protein term is broader than the mechanistic subtype, so propagation to the IRE1-mediated UPR regulation term is conservative and still informative.		proteostasis-workbook-2024; proteostasis-ms1
MIR24-1		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR24-1		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR24-2		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR24-2		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR488		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR488		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR27B		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR27B		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR224		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR224		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR124-1		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR124-1		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR124-2		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR124-2		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
MIR124-3		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	class	PN regulation|Translation regulator	ok_for_propagation_to_go	GO:0006417	regulation of translation	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		no_local_goa		This PN class is the broad translation-regulatory bucket. GO regulation of translation is the conservative propagation target for the umbrella label.		proteostasis-workbook-2024; proteostasis-ms1
MIR124-3		PN regulation|Translation regulator|microRNA	PN regulation	Translation regulator	microRNA			pn_regulation.yaml	group	PN regulation|Translation regulator|microRNA	ok_for_propagation_to_go	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	MIR24-1;MIR24-2;MIR488;MIR27B;MIR224		no_local_goa		This PN group is specifically the microRNA branch under translation regulation. The matching GO process captures translational inhibition mediated by miRNAs.		proteostasis-workbook-2024; proteostasis-ms1
HAPSTR1		PN regulation|Stress response integration|Multi-stress response|Modulation of stress responses	PN regulation	Stress response integration	Multi-stress response	Modulation of stress responses		pn_regulation.yaml	class	PN regulation|Stress response integration	ok_for_propagation_to_go	GO:0006950	response to stress	HAPSTR1;HAPSTR2;HUWE1		supported_by_goa_regulation	GO:0080135 regulation of cellular response to stress	This PN class is an umbrella bucket for multiple stress-response axes. GO response to stress is intentionally broad but is still the most conservative propagation target for the class-level label.		proteostasis-workbook-2024; proteostasis-ms1
HAPSTR2		PN regulation|Stress response integration|Multi-stress response|Modulation of stress responses	PN regulation	Stress response integration	Multi-stress response	Modulation of stress responses		pn_regulation.yaml	class	PN regulation|Stress response integration	ok_for_propagation_to_go	GO:0006950	response to stress	HAPSTR1;HAPSTR2;HUWE1		new_to_goa		This PN class is an umbrella bucket for multiple stress-response axes. GO response to stress is intentionally broad but is still the most conservative propagation target for the class-level label.		proteostasis-workbook-2024; proteostasis-ms1
HUWE1		PN regulation|Stress response integration|Multi-stress response|HAPSTR1 modulator	PN regulation	Stress response integration	Multi-stress response	HAPSTR1 modulator		pn_regulation.yaml	class	PN regulation|Stress response integration	ok_for_propagation_to_go	GO:0006950	response to stress	HAPSTR1;HAPSTR2;HUWE1		entailed_by_goa_closure	GO:0006284 base-excision repair	This PN class is an umbrella bucket for multiple stress-response axes. GO response to stress is intentionally broad but is still the most conservative propagation target for the class-level label.		proteostasis-workbook-2024; proteostasis-ms1
RPS2		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS2		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS2		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS3		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS3		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS3		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS3A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS3A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS3A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS4X		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS4X		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS4X		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS4Y1		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022627 cytosolic small ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS4Y1		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022627 cytosolic small ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS4Y1		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS4Y2		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022627 cytosolic small ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS4Y2		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022627 cytosolic small ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS4Y2		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS5		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS5		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS5		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS6		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS6		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS6		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS7		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS7		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS7		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS8		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS8		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS8		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS9		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS9		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS9		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS10		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS10		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS10		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS11		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS11		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS11		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS12		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS12		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS12		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS13		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS13		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS13		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS14		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS14		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS14		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS15		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS15		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS15		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS15A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS15A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS15A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS16		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS16		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS16		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS17		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS17		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS17		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS18		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS18		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS18		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS19		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS19		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS19		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS20		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS20		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS20		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS21		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS21		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS21		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS23		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS23		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS23		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS24		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS24		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS24		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS25		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS25		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS25		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS26		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS26		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS26		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS27		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS27		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS27		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS27A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS27A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS27A		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS27L		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022627 cytosolic small ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS27L		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022627 cytosolic small ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS27L		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS28		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS28		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS28		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPS29		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPS29		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPS29		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
FAU		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
FAU		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
FAU		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPSA		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPSA		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPSA		Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	40S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit	ok_for_propagation_to_go	GO:0022627	cytosolic small ribosomal subunit	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022627 cytosolic small ribosomal subunit	This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL3		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL3		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL3		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL3L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL3L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL3L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL4		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL4		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL4		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL5		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL5		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL5		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL6		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL6		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL6		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL7		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL7		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL7		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL7A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL7A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL7A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL7L1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL7L1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL7L1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL8		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL8		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL8		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL9		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL9		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL9		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL10		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL10		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL10		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL10A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL10A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL10A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL10L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL10L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL10L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL11		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL11		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL11		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL12		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL12		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL12		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL13		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL13		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL13		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL13A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL13A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL13A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL14		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL14		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL14		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL15		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL15		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL15		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL17		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL17		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL17		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL18		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL18		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL18		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL18A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL18A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL18A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL19		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL19		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL19		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL21		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL21		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL21		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL22		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL22		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL22		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL23		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL23		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL23		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL23A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL23A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL23A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL24		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL24		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL24		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL26		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL26		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL26		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL26L1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL26L1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL26L1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL27		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL27		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL27		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL27A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL27A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL27A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL28		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL28		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL28		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL29		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL29		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL29		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL30		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL30		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL30		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL31		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL31		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL31		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL32		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL32		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL32		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL34		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL34		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL34		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL35		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL35		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL35		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL35A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL35A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL35A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL36		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL36		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL36		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL36A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL36A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL36A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL36AL		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL36AL		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL36AL		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL37		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL37		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL37		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL37A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL37A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL37A		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL38		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL38		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL38		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL39		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL39		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL39		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL39L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL39L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL39L		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
UBA52		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
UBA52		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
UBA52		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPL41		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPL41		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPL41		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPLP0		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPLP0		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPLP0		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPLP1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPLP1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		already_in_goa_exact	GO:0022626 cytosolic ribosome	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPLP1		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RPLP2		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	group	Translation|Cytosolic translation|Ribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term.		proteostasis-workbook-2024; proteostasis-ms1
RPLP2		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	type	Translation|Cytosolic translation|Ribosome|Cytoribosome	ok_for_propagation_to_go	GO:0022626	cytosolic ribosome	RPS2;RPS3;RPS3A;RPS4X;RPS4Y1		entailed_by_goa_closure	GO:0022625 cytosolic large ribosomal subunit	This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
RPLP2		Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	Translation	Cytosolic translation	Ribosome	Cytoribosome	60S subunit	translation.yaml	subtype	Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit	ok_for_propagation_to_go	GO:0022625	cytosolic large ribosomal subunit	RPL3;RPL3L;RPL4;RPL5;RPL6		already_in_goa_exact	GO:0022625 cytosolic large ribosomal subunit	This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
UTP4		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
UTP4		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
WDR43		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
WDR43		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
HEATR1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
HEATR1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
UTP15		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
UTP15		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
WDR75		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
WDR75		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOL11		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOL11		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-A complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		more_specific_than_existing_goa	GO:0005634 nucleus;GO:0005730 nucleolus	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
PWP2		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000028 ribosomal small subunit assembly;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
PWP2		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
UTP6		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
UTP6		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
WDR3		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
WDR3		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TBL3		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TBL3		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
UTP18		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
UTP18		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
WDR36		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
WDR36		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
DDX21		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DDX21		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		more_specific_than_existing_goa	GO:0005730 nucleolus	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOP2		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000027 ribosomal large subunit assembly;GO:0000470 maturation of LSU-rRNA;GO:0006364 rRNA processing;GO:0042273 ribosomal large subunit biogenesis;GO:0070475 rRNA base methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP2		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-B complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		more_specific_than_existing_goa	GO:0005634 nucleus;GO:0005730 nucleolus	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RRP7A		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RRP7A		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOL6		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOL6		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
CSNK2B		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
CSNK2B		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		more_specific_than_existing_goa	GO:0005634 nucleus	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RRP36		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RRP36		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	UTP-C complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		more_specific_than_existing_goa	GO:0005730 nucleolus	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SNORD3A		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
SNORD3A		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		new_to_goa		This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOP56		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000451 rRNA 2'-O-methylation;GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP56		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOP58		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000451 rRNA 2'-O-methylation;GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP58		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SNU13		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
SNU13		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
FBL		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000451 rRNA 2'-O-methylation;GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0031167 rRNA methylation;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
FBL		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RRP9		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RRP9		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	U3 snoRNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
IMP3		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	IMP3-IMP4 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
IMP3		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	IMP3-IMP4 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
IMP4		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	IMP3-IMP4 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
IMP4		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	IMP3-IMP4 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
MPHOSPH10		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	IMP3-IMP4 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
MPHOSPH10		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	IMP3-IMP4 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RCL1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|RCL1-BMS1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	RCL1-BMS1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RCL1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|RCL1-BMS1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	RCL1-BMS1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
BMS1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|RCL1-BMS1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	RCL1-BMS1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
BMS1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|RCL1-BMS1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	RCL1-BMS1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
EMG1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis;GO:0070475 rRNA base methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
EMG1		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOP14		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP14		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOC4L		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOC4L		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
UTP14A		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
UTP14A		Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	SSU processosome	EMG1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	ok_for_propagation_to_go	GO:0032040	small-subunit processome	UTP4;WDR43;HEATR1;UTP15;WDR75		already_in_goa_exact	GO:0032040 small-subunit processome	This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
BUD23		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0070476 rRNA (guanine-N7)-methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
BUD23		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5B		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0042255 ribosome assembly	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
EIF5B		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
BYSL		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
BYSL		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		already_in_goa_exact	GO:0030688 preribosome, small subunit precursor	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
LTV1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
LTV1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		already_in_goa_exact	GO:0030688 preribosome, small subunit precursor	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOB1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOB1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		already_in_goa_exact	GO:0030688 preribosome, small subunit precursor	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
PNO1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
PNO1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RACK1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RACK1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RIOK1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RIOK1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		already_in_goa_exact	GO:0030688 preribosome, small subunit precursor	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RIOK2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RIOK2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		already_in_goa_exact	GO:0030688 preribosome, small subunit precursor	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RIOK3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RIOK3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		already_in_goa_exact	GO:0030688 preribosome, small subunit precursor	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RRP12		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RRP12		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TRMT112		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000470 maturation of LSU-rRNA;GO:0030490 maturation of SSU-rRNA;GO:0031167 rRNA methylation;GO:0070476 rRNA (guanine-N7)-methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TRMT112		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		more_specific_than_existing_goa	GO:0032991 protein-containing complex	This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TSR1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TSR1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TSR2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TSR2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TSR3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000154 rRNA modification;GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TSR3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-40S complex		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	ok_for_propagation_to_go	GO:0030688	preribosome, small subunit precursor	BUD23;EIF5B;BYSL;LTV1;NOB1		new_to_goa		This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RSL24D1		Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	Translation	Cytosolic translation	Ribosome biogenesis factor	60S maturation		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0042273 ribosomal large subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RSL24D1		Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	Translation	Cytosolic translation	Ribosome biogenesis factor	60S maturation		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	ok_for_propagation_to_go	GO:0000027	ribosomal large subunit assembly	RSL24D1;BCCIP		more_specific_than_existing_goa	GO:0042273 ribosomal large subunit biogenesis	This PN type denotes 60S maturation factors. Ribosomal large subunit assembly captures the shared maturation process.		proteostasis-workbook-2024; proteostasis-ms1
BCCIP		Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	Translation	Cytosolic translation	Ribosome biogenesis factor	60S maturation		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
BCCIP		Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	Translation	Cytosolic translation	Ribosome biogenesis factor	60S maturation		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	ok_for_propagation_to_go	GO:0000027	ribosomal large subunit assembly	RSL24D1;BCCIP		new_to_goa		This PN type denotes 60S maturation factors. Ribosomal large subunit assembly captures the shared maturation process.		proteostasis-workbook-2024; proteostasis-ms1
PES1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
PES1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		already_in_goa_exact	GO:0030687 preribosome, large subunit precursor	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
BOP1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
BOP1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		already_in_goa_exact	GO:0030687 preribosome, large subunit precursor	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
WDR12		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
WDR12		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		already_in_goa_exact	GO:0030687 preribosome, large subunit precursor	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
DDX27		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DDX27		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	PeBoW complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
PELP1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	Rix1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
PELP1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	Rix1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TEX10		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	Rix1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TEX10		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	Rix1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
WDR18		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	Rix1 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
WDR18		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	Rix1 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NKRF		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	XND complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NKRF		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	XND complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
XRN2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	XND complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
XRN2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	XND complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
DHX15		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	XND complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DHX15		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	XND complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
AATF		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	ANN complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
AATF		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	ANN complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NGDN		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	ANN complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NGDN		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	ANN complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOL10		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	ANN complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOL10		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	ANN complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
ILF2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	NF45-NF90 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ILF2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	NF45-NF90 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		more_specific_than_existing_goa	GO:1990904 ribonucleoprotein complex	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
ILF3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	NF45-NF90 complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ILF3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	NF45-NF90 complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		more_specific_than_existing_goa	GO:1990904 ribonucleoprotein complex	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
EIF6		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000054 ribosomal subunit export from nucleus;GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA;GO:0042256 cytosolic ribosome assembly;GO:0042273 ribosomal large subunit biogenesis;GO:1902626 assembly of large subunit precursor of preribosome	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
EIF6		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
MRTO4		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000027 ribosomal large subunit assembly;GO:0006364 rRNA processing;GO:0042273 ribosomal large subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
MRTO4		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		already_in_goa_exact	GO:0030687 preribosome, large subunit precursor	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
DUSP12		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DUSP12		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
SBDS		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
SBDS		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
EFL1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0042256 cytosolic ribosome assembly	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
EFL1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		more_specific_than_existing_goa	GO:1990904 ribonucleoprotein complex	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
TMA16		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0042273 ribosomal large subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TMA16		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP4		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
GTPBP4		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
LLPH		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
LLPH		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
ZNF593		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ZNF593		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
GNL2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
GNL2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
LSG1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000054 ribosomal subunit export from nucleus	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
LSG1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC21		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DNAJC21		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	non 5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RRS1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RRS1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		already_in_goa_exact	GO:0030687 preribosome, large subunit precursor	This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
RPF2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA;GO:0006364 rRNA processing;GO:0042273 ribosomal large subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RPF2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NOP53		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000027 ribosomal large subunit assembly;GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP53		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
HEATR3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0042273 ribosomal large subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
HEATR3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S complex	5S RNP complex	translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	ok_for_propagation_to_go	GO:0030687	preribosome, large subunit precursor	PES1;BOP1;WDR12;DDX27;PELP1		new_to_goa		This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NMD3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S export adapter	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S export adapter		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000055 ribosomal large subunit export from nucleus	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RAE1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S export adapter	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-60S export adapter		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
FCF1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
FCF1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		entailed_by_goa_closure	GO:0030490 maturation of SSU-rRNA	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
NOB1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOB1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		already_in_goa_exact	GO:0006364 rRNA processing	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
RMRP		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		no_local_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RMRP		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		no_local_goa		This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PARN		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
PARN		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		new_to_goa		This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EXOSC10		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000460 maturation of 5.8S rRNA;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
EXOSC10		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		already_in_goa_exact	GO:0006364 rRNA processing	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
XRN2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
XRN2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		already_in_goa_exact	GO:0006364 rRNA processing	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
ISG20L2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ISG20L2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		more_specific_than_existing_goa	GO:0006396 RNA processing	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DIS3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DIS3		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		already_in_goa_exact	GO:0006364 rRNA processing	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
ERI1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000460 maturation of 5.8S rRNA;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0031125 rRNA 3'-end processing	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ERI1		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	FCF1;NOB1;RMRP;PARN;EXOSC10		already_in_goa_exact	GO:0006364 rRNA processing	This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
ZFP42		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-5S rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ZFP42		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-5S rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	ZFP42;REXO2		new_to_goa		This PN type denotes nucleases in pre-5S rRNA processing. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
REXO2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-5S rRNA processing nuclease		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
REXO2		Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	Translation	Cytosolic translation	Ribosome biogenesis factor	pre-5S rRNA processing nuclease		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	ok_for_propagation_to_go	GO:0006364	rRNA processing	ZFP42;REXO2		more_specific_than_existing_goa	GO:0006139 nucleobase-containing compound metabolic process;GO:0016070 RNA metabolic process	This PN type denotes nucleases in pre-5S rRNA processing. rRNA processing is the appropriate shared process target.		proteostasis-workbook-2024; proteostasis-ms1
LOC124902573		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		no_local_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
LOC124902573		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		no_local_goa		This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
EMG1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis;GO:0070475 rRNA base methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
EMG1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0070475 rRNA base methylation	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
TSR3		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000154 rRNA modification;GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
TSR3		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		already_in_goa_exact	GO:0000154 rRNA modification	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
NAT10		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000154 rRNA modification;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis;GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NAT10		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		already_in_goa_exact	GO:0000154 rRNA modification	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
BUD23		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0006364 rRNA processing;GO:0070476 rRNA (guanine-N7)-methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
BUD23		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0070476 rRNA (guanine-N7)-methylation	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
DIMT1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000154 rRNA modification;GO:0006364 rRNA processing;GO:0031167 rRNA methylation;GO:0042274 ribosomal small subunit biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DIMT1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		already_in_goa_exact	GO:0000154 rRNA modification	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
RRP8		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		new_to_goa		This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
RRP8		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		new_to_goa		This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
NSUN5		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0070475 rRNA base methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NSUN5		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0070475 rRNA base methylation	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
ZCCHC4		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0031167 rRNA methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
ZCCHC4		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0031167 rRNA methylation	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
NOP2		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000027 ribosomal large subunit assembly;GO:0000470 maturation of LSU-rRNA;GO:0006364 rRNA processing;GO:0042273 ribosomal large subunit biogenesis;GO:0070475 rRNA base methylation	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP2		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0070475 rRNA base methylation	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
DKC1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006364 rRNA processing;GO:0031118 rRNA pseudouridine synthesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
DKC1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0031118 rRNA pseudouridine synthesis	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
GAR1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
GAR1		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0000454 snoRNA guided rRNA pseudouridine synthesis	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
NHP2		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		entailed_by_goa_closure	GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0031118 rRNA pseudouridine synthesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NHP2		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0031118 rRNA pseudouridine synthesis	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
NOP10		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	group	Translation|Cytosolic translation|Ribosome biogenesis factor	ok_for_propagation_to_go	GO:0042254	ribosome biogenesis	AATF;UTP4;IMP3;NOP56		already_in_goa_exact	GO:0042254 ribosome biogenesis	This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target.	This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself.	proteostasis-workbook-2024; proteostasis-ms1
NOP10		Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation	Cytosolic translation	Ribosome biogenesis factor	rRNA modification		translation.yaml	type	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	LOC124902573;EMG1;TSR3;NAT10;BUD23		entailed_by_goa_closure	GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0031118 rRNA pseudouridine synthesis	This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S1		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S1		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2 complex	ok_for_propagation_to_go	GO:0005850	eukaryotic translation initiation factor 2 complex	EIF2S1;EIF2S2;EIF2S3;EIF2S3B		already_in_goa_exact	GO:0005850 eukaryotic translation initiation factor 2 complex	This PN type denotes component membership in the eIF2 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S2		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S2		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2 complex	ok_for_propagation_to_go	GO:0005850	eukaryotic translation initiation factor 2 complex	EIF2S1;EIF2S2;EIF2S3;EIF2S3B		already_in_goa_exact	GO:0005850 eukaryotic translation initiation factor 2 complex	This PN type denotes component membership in the eIF2 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S3		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S3		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2 complex	ok_for_propagation_to_go	GO:0005850	eukaryotic translation initiation factor 2 complex	EIF2S1;EIF2S2;EIF2S3;EIF2S3B		already_in_goa_exact	GO:0005850 eukaryotic translation initiation factor 2 complex	This PN type denotes component membership in the eIF2 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S3B		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		entailed_by_goa_closure	GO:0001731 formation of translation preinitiation complex;GO:0003743 translation initiation factor activity	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2S3B		Translation|Cytosolic translation|Translation initiation|eIF2 complex	Translation	Cytosolic translation	Translation initiation	eIF2 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2 complex	ok_for_propagation_to_go	GO:0005850	eukaryotic translation initiation factor 2 complex	EIF2S1;EIF2S2;EIF2S3;EIF2S3B		already_in_goa_exact	GO:0005850 eukaryotic translation initiation factor 2 complex	This PN type denotes component membership in the eIF2 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B1		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B1		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2B complex	ok_for_propagation_to_go	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1;EIF2B2;EIF2B3;EIF2B4;EIF2B5		already_in_goa_exact	GO:0005851 eukaryotic translation initiation factor 2B complex	This PN type denotes component membership in the eIF2B complex. The corresponding GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B2		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B2		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2B complex	ok_for_propagation_to_go	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1;EIF2B2;EIF2B3;EIF2B4;EIF2B5		already_in_goa_exact	GO:0005851 eukaryotic translation initiation factor 2B complex	This PN type denotes component membership in the eIF2B complex. The corresponding GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B3		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B3		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2B complex	ok_for_propagation_to_go	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1;EIF2B2;EIF2B3;EIF2B4;EIF2B5		already_in_goa_exact	GO:0005851 eukaryotic translation initiation factor 2B complex	This PN type denotes component membership in the eIF2B complex. The corresponding GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B4		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B4		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2B complex	ok_for_propagation_to_go	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1;EIF2B2;EIF2B3;EIF2B4;EIF2B5		already_in_goa_exact	GO:0005851 eukaryotic translation initiation factor 2B complex	This PN type denotes component membership in the eIF2B complex. The corresponding GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B5		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2B5		Translation|Cytosolic translation|Translation initiation|eIF2B complex	Translation	Cytosolic translation	Translation initiation	eIF2B complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF2B complex	ok_for_propagation_to_go	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B1;EIF2B2;EIF2B3;EIF2B4;EIF2B5		already_in_goa_exact	GO:0005851 eukaryotic translation initiation factor 2B complex	This PN type denotes component membership in the eIF2B complex. The corresponding GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3A		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3A		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3B		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3B		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3C		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3C		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3CL		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3CL		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3D		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3D		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3E		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3E		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3F		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3F		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3G		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3G		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3H		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3H		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3I		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3I		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3J		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3J		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3K		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3K		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3L		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3L		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF3M		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3M		Translation|Cytosolic translation|Translation initiation|eIF3 complex	Translation	Cytosolic translation	Translation initiation	eIF3 complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A;EIF3B;EIF3C;EIF3CL;EIF3D		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate.		proteostasis-workbook-2024; proteostasis-ms1
EIF4A1		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4A1		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4A2		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4A2		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E2		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E2		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E3		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E3		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4G1		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4G1		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4G2		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4G2		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF4G3		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4G3		Translation|Cytosolic translation|Translation initiation|eIF4F complex	Translation	Cytosolic translation	Translation initiation	eIF4F complex		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|eIF4F complex	ok_for_propagation_to_go	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4A1;EIF4A2;EIF4E;EIF4E2;EIF4E3		already_in_goa_exact	GO:0016281 eukaryotic translation initiation factor 4F complex	This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
EIF1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF1AX		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF1AX		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF1AY		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF1AY		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4B		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4B		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4H		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4H		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4EBP1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		supported_by_goa_regulation	GO:0045947 negative regulation of translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4EBP1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4EBP2		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		more_specific_than_existing_goa	GO:0006412 translation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4EBP2		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		more_specific_than_existing_goa	GO:0006412 translation	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4EBP3		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		supported_by_goa_regulation	GO:0045947 negative regulation of translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4EBP3		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5B		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5B		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1L		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1L		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1L2A		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1L2A		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1L2B		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC1L2B		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC3		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC3		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC4		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		more_specific_than_existing_goa	GO:0006412 translation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC4		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		more_specific_than_existing_goa	GO:0006412 translation	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC4L		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC4L		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC5		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PABPC5		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
DHX29		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DHX29		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		more_specific_than_existing_goa	GO:0006413 translational initiation	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
DDX3X		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DDX3X		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		more_specific_than_existing_goa	GO:0006413 translational initiation	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
DDX3Y		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DDX3Y		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
VCP		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		new_to_goa		This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
VCP		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2A		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		already_in_goa_exact	GO:0006413 translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2A		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
BZW1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		supported_by_goa_regulation	GO:0006446 regulation of translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
BZW1		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
BZW2		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Cytosolic translation|Translation initiation	ok_for_propagation_to_go	GO:0006413	translational initiation	EIF2S1;EIF2S2;EIF2S3;EIF2S3B;EIF2B1		supported_by_goa_regulation	GO:0006446 regulation of translational initiation	This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
BZW2		Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation	Cytosolic translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		new_to_goa		This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
EEF1A1		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EEF1A2		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EEF1B2		Translation|Cytosolic translation|Translation elongation|EEF1B complex	Translation	Cytosolic translation	Translation elongation	EEF1B complex		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|EEF1B complex	ok_for_propagation_to_go	GO:0005853	eukaryotic translation elongation factor 1 complex	EEF1B2;EEF1D;EEF1G		already_in_goa_exact	GO:0005853 eukaryotic translation elongation factor 1 complex	This PN type denotes EEF1B complex components. The GO eukaryotic translation elongation factor 1 complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EEF1D		Translation|Cytosolic translation|Translation elongation|EEF1B complex	Translation	Cytosolic translation	Translation elongation	EEF1B complex		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|EEF1B complex	ok_for_propagation_to_go	GO:0005853	eukaryotic translation elongation factor 1 complex	EEF1B2;EEF1D;EEF1G		already_in_goa_exact	GO:0005853 eukaryotic translation elongation factor 1 complex	This PN type denotes EEF1B complex components. The GO eukaryotic translation elongation factor 1 complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EEF1G		Translation|Cytosolic translation|Translation elongation|EEF1B complex	Translation	Cytosolic translation	Translation elongation	EEF1B complex		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|EEF1B complex	ok_for_propagation_to_go	GO:0005853	eukaryotic translation elongation factor 1 complex	EEF1B2;EEF1D;EEF1G		more_specific_than_existing_goa	GO:0005737 cytoplasm	This PN type denotes EEF1B complex components. The GO eukaryotic translation elongation factor 1 complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
AARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
CARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
DARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
EPRS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
FARSA		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
FARSB		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		entailed_by_goa_closure	GO:0004826 phenylalanine-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
GARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
HARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
IARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
KARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
LARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
MARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
NARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
QARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
RARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
SARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
TARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
TARS3		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
VARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
WARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
YARS1		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
PSTK		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		new_to_goa		This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
SEPSECS		Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation	Cytosolic translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS1;CARS1;DARS1;EPRS1;FARSA		new_to_goa		This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.	AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation.	proteostasis-workbook-2024; proteostasis-ms1; file:human/AARSD1/AARSD1-ai-review.yaml; file:human/AARSD1/AARSD1-notes.md; PMID:38869066
DTD1		Translation|Cytosolic translation|Translation elongation|tRNA deacylase	Translation	Cytosolic translation	Translation elongation	tRNA deacylase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA deacylase	ok_for_propagation_to_go	GO:0002161	aminoacyl-tRNA deacylase activity	DTD1;DTD2		already_in_goa_exact	GO:0002161 aminoacyl-tRNA deacylase activity	This PN type denotes tRNA deacylases. The GO aminoacyl-tRNA deacylase activity term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
DTD2		Translation|Cytosolic translation|Translation elongation|tRNA deacylase	Translation	Cytosolic translation	Translation elongation	tRNA deacylase		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|tRNA deacylase	ok_for_propagation_to_go	GO:0002161	aminoacyl-tRNA deacylase activity	DTD1;DTD2		already_in_goa_exact	GO:0002161 aminoacyl-tRNA deacylase activity	This PN type denotes tRNA deacylases. The GO aminoacyl-tRNA deacylase activity term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
AIMP1		Translation|Cytosolic translation|Translation elongation|multisynthase complex	Translation	Cytosolic translation	Translation elongation	multisynthase complex		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|multisynthase complex	ok_for_propagation_to_go	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	AIMP1;AIMP2;EEF1E1		already_in_goa_exact	GO:0017101 aminoacyl-tRNA synthetase multienzyme complex	This PN type denotes the multisynthetase complex. The GO aminoacyl-tRNA synthetase multienzyme complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
AIMP2		Translation|Cytosolic translation|Translation elongation|multisynthase complex	Translation	Cytosolic translation	Translation elongation	multisynthase complex		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|multisynthase complex	ok_for_propagation_to_go	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	AIMP1;AIMP2;EEF1E1		already_in_goa_exact	GO:0017101 aminoacyl-tRNA synthetase multienzyme complex	This PN type denotes the multisynthetase complex. The GO aminoacyl-tRNA synthetase multienzyme complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EEF1E1		Translation|Cytosolic translation|Translation elongation|multisynthase complex	Translation	Cytosolic translation	Translation elongation	multisynthase complex		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|multisynthase complex	ok_for_propagation_to_go	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	AIMP1;AIMP2;EEF1E1		already_in_goa_exact	GO:0017101 aminoacyl-tRNA synthetase multienzyme complex	This PN type denotes the multisynthetase complex. The GO aminoacyl-tRNA synthetase multienzyme complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
EEF2		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EEF2K		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		more_specific_than_existing_goa	GO:0006414 translational elongation	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EEF2KMT		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		new_to_goa		This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5A		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5AL1		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5A2		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
SECISBP2		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		new_to_goa		This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EEFSEC		Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation	Cytosolic translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
ETF1		Translation|Cytosolic translation|Translation termination|Stop codon recognition	Translation	Cytosolic translation	Translation termination	Stop codon recognition		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		already_in_goa_exact	GO:0006415 translational termination	This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
ETF1		Translation|Cytosolic translation|Translation termination|Stop codon recognition	Translation	Cytosolic translation	Translation termination	Stop codon recognition		translation.yaml	type	Translation|Cytosolic translation|Translation termination|Stop codon recognition	ok_for_propagation_to_go	GO:0016149	translation release factor activity, codon specific	ETF1		already_in_goa_exact	GO:0016149 translation release factor activity, codon specific	This PN type denotes codon-specific stop-codon recognition by release factors. The GO codon-specific release-factor activity term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
GSPT1		Translation|Cytosolic translation|Translation termination|Polypeptide release	Translation	Cytosolic translation	Translation termination	Polypeptide release		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		already_in_goa_exact	GO:0006415 translational termination	This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
GSPT1		Translation|Cytosolic translation|Translation termination|Polypeptide release	Translation	Cytosolic translation	Translation termination	Polypeptide release		translation.yaml	type	Translation|Cytosolic translation|Translation termination|Polypeptide release	ok_for_propagation_to_go	GO:0003747	translation release factor activity	GSPT1;GSPT2		already_in_goa_exact	GO:0003747 translation release factor activity	This PN type denotes release factors that mediate polypeptide release. Translation release factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
GSPT2		Translation|Cytosolic translation|Translation termination|Polypeptide release	Translation	Cytosolic translation	Translation termination	Polypeptide release		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		already_in_goa_exact	GO:0006415 translational termination	This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
GSPT2		Translation|Cytosolic translation|Translation termination|Polypeptide release	Translation	Cytosolic translation	Translation termination	Polypeptide release		translation.yaml	type	Translation|Cytosolic translation|Translation termination|Polypeptide release	ok_for_propagation_to_go	GO:0003747	translation release factor activity	GSPT1;GSPT2		already_in_goa_exact	GO:0003747 translation release factor activity	This PN type denotes release factors that mediate polypeptide release. Translation release factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
ABCE1		Translation|Cytosolic translation|Translation termination|Ribosome splitting	Translation	Cytosolic translation	Translation termination	Ribosome splitting		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		already_in_goa_exact	GO:0006415 translational termination	This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
EIF2D		Translation|Cytosolic translation|Translation termination|tRNA, mRNA release	Translation	Cytosolic translation	Translation termination	tRNA, mRNA release		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		more_specific_than_existing_goa	GO:0043933 protein-containing complex organization	This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DENR		Translation|Cytosolic translation|Translation termination|tRNA, mRNA release	Translation	Cytosolic translation	Translation termination	tRNA, mRNA release		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		new_to_goa		This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MCTS1		Translation|Cytosolic translation|Translation termination|tRNA, mRNA release	Translation	Cytosolic translation	Translation termination	tRNA, mRNA release		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		new_to_goa		This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UPF1		Translation|Cytosolic translation|Translation termination|Modulation of termination	Translation	Cytosolic translation	Translation termination	Modulation of termination		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		supported_by_goa_regulation	GO:0006449 regulation of translational termination	This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UPF2		Translation|Cytosolic translation|Translation termination|Modulation of termination	Translation	Cytosolic translation	Translation termination	Modulation of termination		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		new_to_goa		This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UPF3A		Translation|Cytosolic translation|Translation termination|Modulation of termination	Translation	Cytosolic translation	Translation termination	Modulation of termination		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		new_to_goa		This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UPF3B		Translation|Cytosolic translation|Translation termination|Modulation of termination	Translation	Cytosolic translation	Translation termination	Modulation of termination		translation.yaml	group	Translation|Cytosolic translation|Translation termination	ok_for_propagation_to_go	GO:0006415	translational termination	ETF1;GSPT1;GSPT2;ABCE1;EIF2D		new_to_goa		This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
HSPA14		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide chaperoning	RAC component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning	ok_for_propagation_to_go	GO:0051083	'de novo' cotranslational protein folding	HSPA14;DNAJC2		already_in_goa_exact	GO:0051083 'de novo' cotranslational protein folding	This PN type denotes cotranslational chaperoning of nascent peptides. The GO de novo cotranslational protein folding term is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
HSPA14		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide chaperoning	RAC component	translation.yaml	subtype	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component	ok_for_propagation_to_go	GO:0051083	'de novo' cotranslational protein folding	HSPA14;DNAJC2		already_in_goa_exact	GO:0051083 'de novo' cotranslational protein folding	The ribosome-associated complex is a cotranslational chaperone system for emerging nascent chains. The PN subtype is a specific component class within this mechanism, so propagation to GO 'de novo' cotranslational protein folding is justified but not exact.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC2		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide chaperoning	RAC component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning	ok_for_propagation_to_go	GO:0051083	'de novo' cotranslational protein folding	HSPA14;DNAJC2		already_in_goa_exact	GO:0051083 'de novo' cotranslational protein folding	This PN type denotes cotranslational chaperoning of nascent peptides. The GO de novo cotranslational protein folding term is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DNAJC2		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide chaperoning	RAC component	translation.yaml	subtype	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component	ok_for_propagation_to_go	GO:0051083	'de novo' cotranslational protein folding	HSPA14;DNAJC2		already_in_goa_exact	GO:0051083 'de novo' cotranslational protein folding	The ribosome-associated complex is a cotranslational chaperone system for emerging nascent chains. The PN subtype is a specific component class within this mechanism, so propagation to GO 'de novo' cotranslational protein folding is justified but not exact.		proteostasis-workbook-2024; proteostasis-ms1
NACA		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide sorting	NAC component	translation.yaml	subtype	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	ok_for_propagation_to_go	GO:0005854	nascent polypeptide-associated complex	NACA;NACA2;NACAD;BTF3		already_in_goa_exact	GO:0005854 nascent polypeptide-associated complex	This PN subtype denotes NAC components. The GO nascent polypeptide-associated complex term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NACA2		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide sorting	NAC component	translation.yaml	subtype	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	ok_for_propagation_to_go	GO:0005854	nascent polypeptide-associated complex	NACA;NACA2;NACAD;BTF3		already_in_goa_exact	GO:0005854 nascent polypeptide-associated complex	This PN subtype denotes NAC components. The GO nascent polypeptide-associated complex term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
NACAD		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide sorting	NAC component	translation.yaml	subtype	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	ok_for_propagation_to_go	GO:0005854	nascent polypeptide-associated complex	NACA;NACA2;NACAD;BTF3		already_in_goa_exact	GO:0005854 nascent polypeptide-associated complex	This PN subtype denotes NAC components. The GO nascent polypeptide-associated complex term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
BTF3		Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	Translation	Cytosolic translation	Nascent peptide husbandry	Nascent peptide sorting	NAC component	translation.yaml	subtype	Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component	ok_for_propagation_to_go	GO:0005854	nascent polypeptide-associated complex	NACA;NACA2;NACAD;BTF3		already_in_goa_exact	GO:0005854 nascent polypeptide-associated complex	This PN subtype denotes NAC components. The GO nascent polypeptide-associated complex term is the direct complex target.		proteostasis-workbook-2024; proteostasis-ms1
METAP1		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal methionine cleavage from nascent peptide	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal methionine cleavage from nascent peptide		translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal methionine cleavage from nascent peptide	ok_for_propagation_to_go	GO:0004239	initiator methionyl aminopeptidase activity	METAP1;METAP2		already_in_goa_exact	GO:0004239 initiator methionyl aminopeptidase activity	This PN type is represented by METAP1/METAP2. Initiator methionyl aminopeptidase activity captures the shared catalytic function.		proteostasis-workbook-2024; proteostasis-ms1
METAP2		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal methionine cleavage from nascent peptide	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal methionine cleavage from nascent peptide		translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal methionine cleavage from nascent peptide	ok_for_propagation_to_go	GO:0004239	initiator methionyl aminopeptidase activity	METAP1;METAP2		already_in_goa_exact	GO:0004239 initiator methionyl aminopeptidase activity	This PN type is represented by METAP1/METAP2. Initiator methionyl aminopeptidase activity captures the shared catalytic function.		proteostasis-workbook-2024; proteostasis-ms1
NAA10		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatA/NatE complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		more_specific_than_existing_goa	GO:0051604 protein maturation	This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA15		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatA/NatE complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		more_specific_than_existing_goa	GO:0051604 protein maturation	This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA20		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatB complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatB complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		already_in_goa_exact	GO:0006474 N-terminal protein amino acid acetylation	This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA25		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatB complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatB complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		new_to_goa		This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA30		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatC complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		new_to_goa		This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA35		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatC complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		new_to_goa		This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA38		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatC complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		new_to_goa		This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA40		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatD, sole component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatD, sole component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		new_to_goa		This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NAA50		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatE complex component	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	NatE complex component	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		already_in_goa_exact	GO:0006474 N-terminal protein amino acid acetylation	This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
HYPK		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|Modulator of NatA and NatE complexes	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal acetylation of nascent peptide	Modulator of NatA and NatE complexes	translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	ok_for_propagation_to_go	GO:0006474	N-terminal protein amino acid acetylation	NAA10;NAA15;NAA20;NAA25;NAA30		new_to_goa		This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NMT1		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal myristoylation of nascent peptide	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal myristoylation of nascent peptide		translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal myristoylation of nascent peptide	ok_for_propagation_to_go	GO:0006499	N-terminal protein myristoylation	NMT1;NMT2		already_in_goa_exact	GO:0006499 N-terminal protein myristoylation	This PN type denotes NMT-mediated nascent-chain myristoylation. The GO N-terminal protein myristoylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
NMT2		Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal myristoylation of nascent peptide	Translation	Cytosolic translation	Nascent peptide husbandry	N-terminal myristoylation of nascent peptide		translation.yaml	type	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal myristoylation of nascent peptide	ok_for_propagation_to_go	GO:0006499	N-terminal protein myristoylation	NMT1;NMT2		entailed_by_goa_closure	GO:0018008 N-terminal peptidyl-glycine N-myristoylation	This PN type denotes NMT-mediated nascent-chain myristoylation. The GO N-terminal protein myristoylation process is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
HBS1L		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
HBS1L		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		more_specific_than_existing_goa	GO:0002181 cytoplasmic translation;GO:0006414 translational elongation	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP2		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP2		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		more_specific_than_existing_goa	GO:0006414 translational elongation	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
PELO		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
PELO		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
RACK1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
RACK1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
ZNF598		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ZNF598		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
ABCE1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ABCE1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
TRIP4		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
TRIP4		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
ASCC1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ASCC1		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
ASCC2		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ASCC2		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
ASCC3		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ASCC3		Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation	Cytosolic translation	Ribosome-associated QC	Ribosomal rescue		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	ok_for_propagation_to_go	GO:0072344	rescue of stalled cytosolic ribosome	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0072344 rescue of stalled cytosolic ribosome	This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
UFM1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UFM1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UBA5		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UBA5		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UFC1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UFC1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UFL1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UFL1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DDRGK1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
DDRGK1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
CDK5RAP3		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
CDK5RAP3		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UFSP1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UFSP1		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		already_in_goa_exact	GO:0071569 protein ufmylation	This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
UFSP2		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UFSP2		Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation	Cytosolic translation	Ribosome-associated QC	UFMylation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	ok_for_propagation_to_go	GO:0071569	protein ufmylation	UFM1;UBA5;UFC1;UFL1;DDRGK1		new_to_goa		This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
LTN1		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
LTN1		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	LTN1;MKRN1;MKRN2;CNOT4;HUWE1		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type denotes ubiquitination events on stalled translation complexes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MKRN1		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
MKRN1		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	LTN1;MKRN1;MKRN2;CNOT4;HUWE1		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type denotes ubiquitination events on stalled translation complexes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MKRN2		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
MKRN2		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	LTN1;MKRN1;MKRN2;CNOT4;HUWE1		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type denotes ubiquitination events on stalled translation complexes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
CNOT4		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
CNOT4		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	LTN1;MKRN1;MKRN2;CNOT4;HUWE1		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type denotes ubiquitination events on stalled translation complexes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
HUWE1		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
HUWE1		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	LTN1;MKRN1;MKRN2;CNOT4;HUWE1		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type denotes ubiquitination events on stalled translation complexes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
USP10		Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Deubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
USP10		Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Deubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP10;USP21;OTUD3		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN RQC type denotes deubiquitinases acting in ribosome-associated quality control. Deubiquitinase activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
USP21		Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Deubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
USP21		Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Deubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP10;USP21;OTUD3		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN RQC type denotes deubiquitinases acting in ribosome-associated quality control. Deubiquitinase activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
OTUD3		Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Deubiquitination		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
OTUD3		Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	Translation	Cytosolic translation	Ribosome-associated QC	Deubiquitination		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP10;USP21;OTUD3		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN RQC type denotes deubiquitinases acting in ribosome-associated quality control. Deubiquitinase activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
NPLOC4		Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitin recognition	Translation	Cytosolic translation	Ribosome-associated QC	Ubiquitin recognition		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
VCP		Translation|Cytosolic translation|Ribosome-associated QC|VCP system for RQC	Translation	Cytosolic translation	Ribosome-associated QC	VCP system for RQC		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		entailed_by_goa_closure	GO:0140455 cytoplasm protein quality control	The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
UFD1		Translation|Cytosolic translation|Ribosome-associated QC|VCP system for RQC	Translation	Cytosolic translation	Ribosome-associated QC	VCP system for RQC		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ANKZF1		Translation|Cytosolic translation|Ribosome-associated QC|VCP system for RQC	Translation	Cytosolic translation	Ribosome-associated QC	VCP system for RQC		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		already_in_goa_exact	GO:0006515 protein quality control for misfolded or incompletely synthesized proteins	The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
OGT		Translation|Cytosolic translation|Ribosome-associated QC|O-GlcNAclyation	Translation	Cytosolic translation	Ribosome-associated QC	O-GlcNAclyation		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
OGT		Translation|Cytosolic translation|Ribosome-associated QC|O-GlcNAclyation	Translation	Cytosolic translation	Ribosome-associated QC	O-GlcNAclyation		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|O-GlcNAclyation	ok_for_propagation_to_go	GO:0006493	protein O-linked glycosylation	OGT		already_in_goa_exact	GO:0006493 protein O-linked glycosylation	This PN RQC type captures O-GlcNAc modification in the ribosome-associated quality-control context. Protein O-linked glycosylation is the appropriate GO process target.		proteostasis-workbook-2024; proteostasis-ms1
GCN1		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
ABCF2		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
DRG2		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GIGYF1		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GIGYF2		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
EIF4E2		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
EDF1		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
MAP3K20		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
NEMF		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
TCF25		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
EIF5A		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
EIF3J		Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	Translation	Cytosolic translation	Ribosome-associated QC	other RQC processes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GCN1		Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation	Cytosolic translation	Ribosome-associated QC	ubiquitination of eEF1A on stalled ribosomes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
GCN1		Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation	Cytosolic translation	Ribosome-associated QC	ubiquitination of eEF1A on stalled ribosomes		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	GCN1;RNF14;RNF25		new_to_goa		This PN RQC type is a specific ubiquitination bucket for eEF1A on stalled ribosomes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
RNF14		Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation	Cytosolic translation	Ribosome-associated QC	ubiquitination of eEF1A on stalled ribosomes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
RNF14		Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation	Cytosolic translation	Ribosome-associated QC	ubiquitination of eEF1A on stalled ribosomes		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	GCN1;RNF14;RNF25		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type is a specific ubiquitination bucket for eEF1A on stalled ribosomes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
RNF25		Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation	Cytosolic translation	Ribosome-associated QC	ubiquitination of eEF1A on stalled ribosomes		translation.yaml	group	Translation|Cytosolic translation|Ribosome-associated QC	ok_for_propagation_to_go	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	HBS1L;GTPBP1;GTPBP2;PELO;RACK1		new_to_goa		The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.		proteostasis-workbook-2024; proteostasis-ms1
RNF25		Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation	Cytosolic translation	Ribosome-associated QC	ubiquitination of eEF1A on stalled ribosomes		translation.yaml	type	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	GCN1;RNF14;RNF25		already_in_goa_exact	GO:0016567 protein ubiquitination	This PN RQC type is a specific ubiquitination bucket for eEF1A on stalled ribosomes. Protein ubiquitination is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS2		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS2		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS2		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS5		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS5		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS5		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS6		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS6		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS6		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS7		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS7		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS7		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS9		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS9		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS9		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS10		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS10		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS10		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS11		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS11		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS11		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS12		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS12		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS12		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS14		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS14		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS14		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS15		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS15		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS15		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS16		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS16		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS16		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS17		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS17		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS17		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18B		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18B		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18B		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18C		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18C		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18C		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS21		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS21		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS21		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS22		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS22		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS22		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS23		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion;GO:0005840 ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS23		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion;GO:0005840 ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS23		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion;GO:0005840 ribosome	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS24		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS24		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS24		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS25		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS25		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS25		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS26		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS26		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS26		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS27		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS27		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS27		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS28		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS28		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS28		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS30		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS30		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS30		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion;GO:0005840 ribosome	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS31		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS31		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS31		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS33		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS33		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS33		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS34		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS34		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS34		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS35		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS35		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS35		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005763 mitochondrial small ribosomal subunit	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
KGD4		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
KGD4		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
KGD4		Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	28S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	ok_for_propagation_to_go	GO:0005763	mitochondrial small ribosomal subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		more_specific_than_existing_goa	GO:0005739 mitochondrion	This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL1		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL1		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL1		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL2		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL2		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL2		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL3		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL3		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL3		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL4		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL4		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL4		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL9		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL9		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL9		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL10		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL10		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL10		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL11		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL11		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL11		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL12		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL12		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL12		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL13		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL13		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL13		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL14		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL14		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL14		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL15		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL15		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL15		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL16		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL16		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL16		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL17		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL17		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL17		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL18		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL18		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL18		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL19		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL19		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL19		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL20		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL20		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL20		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL21		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL21		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL21		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL22		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL22		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL22		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL23		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL23		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL23		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL24		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL24		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL24		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL27		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL27		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL27		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL28		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL28		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL28		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL30		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL30		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL30		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL32		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL32		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL32		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL33		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL33		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL33		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL34		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL34		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL34		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL35		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL35		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL35		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL36		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL36		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL36		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL37		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL37		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL37		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL38		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL38		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL38		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL39		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL39		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL39		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL40		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL40		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL40		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL41		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL41		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL41		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL42		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL42		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL42		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL43		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL43		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL43		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL44		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL44		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL44		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL45		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL45		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL45		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL46		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL46		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL46		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL47		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL47		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL47		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL48		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL48		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL48		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL49		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL49		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL49		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL50		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL50		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL50		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL51		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL51		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL51		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL52		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL52		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL52		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL53		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL53		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL53		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL54		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL54		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL54		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL55		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL55		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL55		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL57		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL57		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		already_in_goa_exact	GO:0005761 mitochondrial ribosome	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL57		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL58		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPL58		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL58		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
GADD45GIP1		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
GADD45GIP1		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
GADD45GIP1		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18A		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	group	Translation|Mitochondrial translation|Ribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit	This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18A		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	type	Translation|Mitochondrial translation|Ribosome|Mitoribosome	ok_for_propagation_to_go	GO:0005761	mitochondrial ribosome	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9		entailed_by_goa_closure	GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit	This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target.		proteostasis-workbook-2024; proteostasis-ms1
MRPS18A		Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	Translation	Mitochondrial translation	Ribosome	Mitoribosome	39S subunit	translation.yaml	subtype	Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit	ok_for_propagation_to_go	GO:0005762	mitochondrial large ribosomal subunit	MRPL1;MRPL2;MRPL3;MRPL4;MRPL9		already_in_goa_exact	GO:0005762 mitochondrial large ribosomal subunit	This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
METTL15		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:0180026 mitochondrial small ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
METTL15		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:0070475 rRNA base methylation	This PN type denotes modification of mitochondrial small-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
NSUN4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
NSUN4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:0031167 rRNA methylation	This PN type denotes modification of mitochondrial small-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
MTERF4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTERF4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		more_specific_than_existing_goa	GO:0006364 rRNA processing	This PN type denotes modification of mitochondrial small-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
TFB1M		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:0180026 mitochondrial small ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TFB1M		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0000154 rRNA modification	This PN type denotes modification of mitochondrial small-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
TRMT2B		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TRMT2B		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		more_specific_than_existing_goa	GO:0006396 RNA processing	This PN type denotes modification of mitochondrial small-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
MRM1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MRM1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	MRM1;MRM2;MRM3;TRMT61B;RPUSD4		already_in_goa_exact	GO:0000154 rRNA modification	This PN type denotes modification of mitochondrial large-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
MRM2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MRM2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	MRM1;MRM2;MRM3;TRMT61B;RPUSD4		entailed_by_goa_closure	GO:0000451 rRNA 2'-O-methylation;GO:0031167 rRNA methylation	This PN type denotes modification of mitochondrial large-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
MRM3		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MRM3		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	MRM1;MRM2;MRM3;TRMT61B;RPUSD4		entailed_by_goa_closure	GO:0000451 rRNA 2'-O-methylation;GO:0070039 rRNA (guanosine-2'-O-ribose)-methyltransferase activity	This PN type denotes modification of mitochondrial large-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
TRMT61B		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TRMT61B		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA methylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	MRM1;MRM2;MRM3;TRMT61B;RPUSD4		new_to_goa		This PN type denotes modification of mitochondrial large-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
RPUSD4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA pseudouridylation	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
RPUSD4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA pseudouridylation	translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification	ok_for_propagation_to_go	GO:0000154	rRNA modification	MRM1;MRM2;MRM3;TRMT61B;RPUSD4		already_in_goa_exact	GO:0000154 rRNA modification	This PN type denotes modification of mitochondrial large-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries.		proteostasis-workbook-2024; proteostasis-ms1
RPUSD4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA modification	rRNA pseudouridylation	translation.yaml	subtype	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	ok_for_propagation_to_go	GO:0120159	rRNA pseudouridine synthase activity	RPUSD4		more_specific_than_existing_goa	GO:0009982 pseudouridine synthase activity	This PN subtype denotes mitochondrial rRNA pseudouridylation factors. rRNA pseudouridine synthase activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
ERAL1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA chaperone	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA chaperone		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:0180026 mitochondrial small ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
RBFA		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA chaperone	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA chaperone		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:0180026 mitochondrial small ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
RCC1L		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA chaperone	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit rRNA chaperone		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
YBEY		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit assembly		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
YBEY		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	28S subunit assembly		translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	YBEY		new_to_goa		This PN type denotes 28S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTERF4		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA chaperone	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA chaperone		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PTCD1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA chaperone	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit rRNA chaperone		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTG2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTG2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	MTG2;GTPBP6;MTG1;GTPBP10		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN type denotes 39S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP6		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP6		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	MTG2;GTPBP6;MTG1;GTPBP10		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN type denotes 39S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTG1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTG1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	MTG2;GTPBP6;MTG1;GTPBP10		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN type denotes 39S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP10		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP10		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	39S subunit assembly		translation.yaml	type	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	MTG2;GTPBP6;MTG1;GTPBP10		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN type denotes 39S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MALSU1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Regulation of 28S-39S subunit association	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Regulation of 28S-39S subunit association		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MIEF1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Regulation of 28S-39S subunit association	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Regulation of 28S-39S subunit association		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
NDUFAB1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Regulation of 28S-39S subunit association	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Regulation of 28S-39S subunit association		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
NOA1		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DDX28		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
DHX30		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
FASTKD2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		entailed_by_goa_closure	GO:1902775 mitochondrial large ribosomal subunit assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MPV17L2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTERF3		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
NGRN		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	Specific function in mitoribosome biogenesis unknown		translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		already_in_goa_exact	GO:0061668 mitochondrial ribosome assembly	This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
PRORP		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	pre-rRNA processing nuclease	Subunit of RNAse P complex	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
TRMT10C		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	pre-rRNA processing nuclease	Subunit of RNAse P complex	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
HSD17B10		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	pre-rRNA processing nuclease	Subunit of RNAse P complex	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
ELAC2		Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|RNAse Z	Translation	Mitochondrial translation	Mitoribosome biogenesis factor	pre-rRNA processing nuclease	RNAse Z	translation.yaml	group	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	ok_for_propagation_to_go	GO:0061668	mitochondrial ribosome assembly	METTL15;NSUN4;MTERF4;TFB1M;TRMT2B		new_to_goa		This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target.		proteostasis-workbook-2024; proteostasis-ms1
MTIF2		Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation	Mitochondrial translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Mitochondrial translation|Translation initiation	ok_for_propagation_to_go	GO:0070124	mitochondrial translational initiation	MTIF2;MTIF3;PTCD3		already_in_goa_exact	GO:0070124 mitochondrial translational initiation	This PN group denotes mitochondrial translation initiation machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MTIF2		Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation	Mitochondrial translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	MTIF2;MTIF3;PTCD3		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups mitochondrial initiation factors. Translation initiation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
MTIF3		Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation	Mitochondrial translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Mitochondrial translation|Translation initiation	ok_for_propagation_to_go	GO:0070124	mitochondrial translational initiation	MTIF2;MTIF3;PTCD3		already_in_goa_exact	GO:0070124 mitochondrial translational initiation	This PN group denotes mitochondrial translation initiation machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MTIF3		Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation	Mitochondrial translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	MTIF2;MTIF3;PTCD3		already_in_goa_exact	GO:0003743 translation initiation factor activity	This PN type groups mitochondrial initiation factors. Translation initiation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
PTCD3		Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation	Mitochondrial translation	Translation initiation	assorted initiation factors		translation.yaml	group	Translation|Mitochondrial translation|Translation initiation	ok_for_propagation_to_go	GO:0070124	mitochondrial translational initiation	MTIF2;MTIF3;PTCD3		more_specific_than_existing_goa	GO:0032543 mitochondrial translation	This PN group denotes mitochondrial translation initiation machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
PTCD3		Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation	Mitochondrial translation	Translation initiation	assorted initiation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	ok_for_propagation_to_go	GO:0003743	translation initiation factor activity	MTIF2;MTIF3;PTCD3		new_to_goa		This PN type groups mitochondrial initiation factors. Translation initiation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
TUFM		Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	Translation	Mitochondrial translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	TUFM;TSFM;GFM1;GUF1		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups mitochondrial elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
TSFM		Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	Translation	Mitochondrial translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	TUFM;TSFM;GFM1;GUF1		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups mitochondrial elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
GFM1		Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	Translation	Mitochondrial translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	TUFM;TSFM;GFM1;GUF1		already_in_goa_exact	GO:0003746 translation elongation factor activity	This PN type groups mitochondrial elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
GUF1		Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	Translation	Mitochondrial translation	Translation elongation	assorted elongation factors		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	ok_for_propagation_to_go	GO:0003746	translation elongation factor activity	TUFM;TSFM;GFM1;GUF1		more_specific_than_existing_goa	GO:0006412 translation	This PN type groups mitochondrial elongation factors. Translation elongation factor activity is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
AARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
CARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
DARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
EARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
FARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
GARS1		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
HARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		entailed_by_goa_closure	GO:0004821 histidine-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
IARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
KARS1		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
LARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
MARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
NARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
PARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
RARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
SARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
TARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
VARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
WARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
YARS2		Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	Translation	Mitochondrial translation	Translation elongation	tRNA synthetase		translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|tRNA synthetase	ok_for_propagation_to_go	GO:0004812	aminoacyl-tRNA ligase activity	AARS2;CARS2;DARS2;EARS2;FARS2		already_in_goa_exact	GO:0004812 aminoacyl-tRNA ligase activity	This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target.		proteostasis-workbook-2024; proteostasis-ms1
QRSL1		Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	Translation	Mitochondrial translation	Translation elongation	Amidotransferase complex	Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex	ok_for_propagation_to_go	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	QRSL1;GATB;GATC		already_in_goa_exact	GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex	This PN type denotes the mitochondrial GatCAB amidotransferase complex. The GO glutamyl-tRNA(Gln) amidotransferase complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
QRSL1		Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	Translation	Mitochondrial translation	Translation elongation	Amidotransferase complex	Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	translation.yaml	subtype	Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	ok_for_propagation_to_go	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	QRSL1;GATB;GATC		already_in_goa_exact	GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex	This PN subtype is the GatCAB-mediated conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln). The GO amidotransferase complex term is the direct shared target.		proteostasis-workbook-2024; proteostasis-ms1
GATB		Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	Translation	Mitochondrial translation	Translation elongation	Amidotransferase complex	Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex	ok_for_propagation_to_go	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	QRSL1;GATB;GATC		already_in_goa_exact	GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex	This PN type denotes the mitochondrial GatCAB amidotransferase complex. The GO glutamyl-tRNA(Gln) amidotransferase complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
GATB		Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	Translation	Mitochondrial translation	Translation elongation	Amidotransferase complex	Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	translation.yaml	subtype	Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	ok_for_propagation_to_go	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	QRSL1;GATB;GATC		already_in_goa_exact	GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex	This PN subtype is the GatCAB-mediated conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln). The GO amidotransferase complex term is the direct shared target.		proteostasis-workbook-2024; proteostasis-ms1
GATC		Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	Translation	Mitochondrial translation	Translation elongation	Amidotransferase complex	Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	translation.yaml	type	Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex	ok_for_propagation_to_go	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	QRSL1;GATB;GATC		already_in_goa_exact	GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex	This PN type denotes the mitochondrial GatCAB amidotransferase complex. The GO glutamyl-tRNA(Gln) amidotransferase complex term is the direct target.		proteostasis-workbook-2024; proteostasis-ms1
GATC		Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	Translation	Mitochondrial translation	Translation elongation	Amidotransferase complex	Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	translation.yaml	subtype	Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln)	ok_for_propagation_to_go	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex	QRSL1;GATB;GATC		already_in_goa_exact	GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex	This PN subtype is the GatCAB-mediated conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln). The GO amidotransferase complex term is the direct shared target.		proteostasis-workbook-2024; proteostasis-ms1
MTRF1		Translation|Mitochondrial translation|Translation termination|Normal termination	Translation	Mitochondrial translation	Translation termination	Normal termination		translation.yaml	group	Translation|Mitochondrial translation|Translation termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L;MRPL58;MTRFR;MTRES1		already_in_goa_exact	GO:0070126 mitochondrial translational termination	This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MTRF1		Translation|Mitochondrial translation|Translation termination|Normal termination	Translation	Mitochondrial translation	Translation termination	Normal termination		translation.yaml	type	Translation|Mitochondrial translation|Translation termination|Normal termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L		already_in_goa_exact	GO:0070126 mitochondrial translational termination	This PN type denotes normal mitochondrial translation termination. The GO mitochondrial translational termination process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
MTRF1L		Translation|Mitochondrial translation|Translation termination|Normal termination	Translation	Mitochondrial translation	Translation termination	Normal termination		translation.yaml	group	Translation|Mitochondrial translation|Translation termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L;MRPL58;MTRFR;MTRES1		already_in_goa_exact	GO:0070126 mitochondrial translational termination	This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MTRF1L		Translation|Mitochondrial translation|Translation termination|Normal termination	Translation	Mitochondrial translation	Translation termination	Normal termination		translation.yaml	type	Translation|Mitochondrial translation|Translation termination|Normal termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L		already_in_goa_exact	GO:0070126 mitochondrial translational termination	This PN type denotes normal mitochondrial translation termination. The GO mitochondrial translational termination process is the shared target.		proteostasis-workbook-2024; proteostasis-ms1
MRPL58		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	group	Translation|Mitochondrial translation|Translation termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L;MRPL58;MTRFR;MTRES1		already_in_goa_exact	GO:0070126 mitochondrial translational termination	This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MRPL58		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	type	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	ok_for_propagation_to_go	GO:7770016	rescue of stalled mitochondrial ribosome	MRPL58;MTRFR;MTRES1;GTPBP6		already_in_goa_exact	GO:7770016 rescue of stalled mitochondrial ribosome	This PN type denotes handling of stalled mitochondrial ribosomes. The GO rescue of stalled mitochondrial ribosome process is the best matching target.		proteostasis-workbook-2024; proteostasis-ms1
MTRFR		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	group	Translation|Mitochondrial translation|Translation termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L;MRPL58;MTRFR;MTRES1		already_in_goa_exact	GO:0070126 mitochondrial translational termination	This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MTRFR		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	type	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	ok_for_propagation_to_go	GO:7770016	rescue of stalled mitochondrial ribosome	MRPL58;MTRFR;MTRES1;GTPBP6		already_in_goa_exact	GO:7770016 rescue of stalled mitochondrial ribosome	This PN type denotes handling of stalled mitochondrial ribosomes. The GO rescue of stalled mitochondrial ribosome process is the best matching target.		proteostasis-workbook-2024; proteostasis-ms1
MTRES1		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	group	Translation|Mitochondrial translation|Translation termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L;MRPL58;MTRFR;MTRES1		new_to_goa		This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MTRES1		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	type	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	ok_for_propagation_to_go	GO:7770016	rescue of stalled mitochondrial ribosome	MRPL58;MTRFR;MTRES1;GTPBP6		already_in_goa_exact	GO:7770016 rescue of stalled mitochondrial ribosome	This PN type denotes handling of stalled mitochondrial ribosomes. The GO rescue of stalled mitochondrial ribosome process is the best matching target.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP6		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	group	Translation|Mitochondrial translation|Translation termination	ok_for_propagation_to_go	GO:0070126	mitochondrial translational termination	MTRF1;MTRF1L;MRPL58;MTRFR;MTRES1		new_to_goa		This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation.		proteostasis-workbook-2024; proteostasis-ms1
GTPBP6		Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation	Mitochondrial translation	Translation termination	Termination on stalled ribosomes		translation.yaml	type	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	ok_for_propagation_to_go	GO:7770016	rescue of stalled mitochondrial ribosome	MRPL58;MTRFR;MTRES1;GTPBP6		new_to_goa		This PN type denotes handling of stalled mitochondrial ribosomes. The GO rescue of stalled mitochondrial ribosome process is the best matching target.		proteostasis-workbook-2024; proteostasis-ms1
IDE		Extracellular proteostasis|Protease|Extracellular and intracellular	Extracellular proteostasis	Protease	Extracellular and intracellular			extracellular_proteostasis.yaml	class	Extracellular proteostasis|Protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	IDE;MME		entailed_by_goa_closure	GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity	This PN class contains extracellular/intracellular proteases in the extracellular proteostasis branch. The shared molecular-function assertion is peptidase activity; narrower metallopeptidase propagation is handled by the child bucket.		proteostasis-workbook-2024; proteostasis-ms1
IDE		Extracellular proteostasis|Protease|Extracellular and intracellular	Extracellular proteostasis	Protease	Extracellular and intracellular			extracellular_proteostasis.yaml	group	Extracellular proteostasis|Protease|Extracellular and intracellular	ok_for_propagation_to_go	GO:0004222	metalloendopeptidase activity	IDE		already_in_goa_exact	GO:0004222 metalloendopeptidase activity	This PN child bucket is represented by IDE in the current taxonomy and converges on metallopeptidase biology. The GO metalloendopeptidase activity term is the clearest shared target for propagation.		proteostasis-workbook-2024; proteostasis-ms1
MME		Extracellular proteostasis|Protease|Plasma membrane	Extracellular proteostasis	Protease	Plasma membrane			extracellular_proteostasis.yaml	class	Extracellular proteostasis|Protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	IDE;MME		already_in_goa_exact	GO:0008233 peptidase activity	This PN class contains extracellular/intracellular proteases in the extracellular proteostasis branch. The shared molecular-function assertion is peptidase activity; narrower metallopeptidase propagation is handled by the child bucket.		proteostasis-workbook-2024; proteostasis-ms1
MME		Extracellular proteostasis|Protease|Plasma membrane	Extracellular proteostasis	Protease	Plasma membrane			extracellular_proteostasis.yaml	group	Extracellular proteostasis|Protease|Plasma membrane	ok_for_propagation_to_go	GO:0005886	plasma membrane	MME		already_in_goa_exact	GO:0005886 plasma membrane	This PN group captures plasma-membrane-localized extracellular proteases. The source category is location-based rather than a strict GO-equivalent class, so the plasma membrane cellular-component term is used at propagation scope.		proteostasis-workbook-2024; proteostasis-ms1
PIK3CA		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	PI3K complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	ok_for_propagation_to_go	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA;PIK3CB;PIK3CD;PIK3R1;PIK3R2		already_in_goa_exact	GO:0005943 phosphatidylinositol 3-kinase complex, class IA	This leaf contains class IA PI3K catalytic/regulatory subunits in the insulin-signaling arm. The matching GO component term is phosphatidylinositol 3-kinase complex, class IA.		proteostasis-workbook-2026; proteostasis-ms2
PIK3CB		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	PI3K complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	ok_for_propagation_to_go	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA;PIK3CB;PIK3CD;PIK3R1;PIK3R2		already_in_goa_exact	GO:0005943 phosphatidylinositol 3-kinase complex, class IA	This leaf contains class IA PI3K catalytic/regulatory subunits in the insulin-signaling arm. The matching GO component term is phosphatidylinositol 3-kinase complex, class IA.		proteostasis-workbook-2026; proteostasis-ms2
PIK3CD		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	PI3K complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	ok_for_propagation_to_go	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA;PIK3CB;PIK3CD;PIK3R1;PIK3R2		already_in_goa_exact	GO:0005943 phosphatidylinositol 3-kinase complex, class IA	This leaf contains class IA PI3K catalytic/regulatory subunits in the insulin-signaling arm. The matching GO component term is phosphatidylinositol 3-kinase complex, class IA.		proteostasis-workbook-2026; proteostasis-ms2
PIK3R1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	PI3K complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	ok_for_propagation_to_go	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA;PIK3CB;PIK3CD;PIK3R1;PIK3R2		already_in_goa_exact	GO:0005943 phosphatidylinositol 3-kinase complex, class IA	This leaf contains class IA PI3K catalytic/regulatory subunits in the insulin-signaling arm. The matching GO component term is phosphatidylinositol 3-kinase complex, class IA.		proteostasis-workbook-2026; proteostasis-ms2
PIK3R2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	PI3K complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PI3K complex component	ok_for_propagation_to_go	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA;PIK3CB;PIK3CD;PIK3R1;PIK3R2		already_in_goa_exact	GO:0005943 phosphatidylinositol 3-kinase complex, class IA	This leaf contains class IA PI3K catalytic/regulatory subunits in the insulin-signaling arm. The matching GO component term is phosphatidylinositol 3-kinase complex, class IA.		proteostasis-workbook-2026; proteostasis-ms2
PTEN		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PIP3 dephosphorylation	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	PIP3 dephosphorylation	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|PIP3 dephosphorylation	ok_for_propagation_to_go	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PTEN		already_in_goa_exact	GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	This leaf is currently PTEN-like PIP3 dephosphorylation upstream of mTORC1; the matching GO molecular function is phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity.		proteostasis-workbook-2026; proteostasis-ms2
MTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		already_in_goa_exact	GO:0031932 TORC2 complex	This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
RICTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		already_in_goa_exact	GO:0031932 TORC2 complex	This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
MLST8		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		already_in_goa_exact	GO:0031932 TORC2 complex	This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
MAPKAP1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		already_in_goa_exact	GO:0031932 TORC2 complex	This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
DEPTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		new_to_goa		This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
TTI1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		already_in_goa_exact	GO:0031932 TORC2 complex	This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
TELO2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Insulin signaling pathway	AKT1 activator, mTORC2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	ok_for_propagation_to_go	GO:0031932	TORC2 complex	MTOR;RICTOR;MLST8;MAPKAP1;DEPTOR		new_to_goa		This leaf contains mTORC2 components in the insulin-to-mTORC1 upstream arm. The shared GO assertion is TORC2 complex membership.		proteostasis-workbook-2026; proteostasis-ms2
LAMTOR1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Ragulator complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	ok_for_propagation_to_go	GO:0071986	Ragulator complex	LAMTOR1;LAMTOR2;LAMTOR3;LAMTOR4;LAMTOR5		already_in_goa_exact	GO:0071986 Ragulator complex	This PN leaf is restricted to Ragulator complex subunits. The matching GO cellular-component term is Ragulator complex.		proteostasis-workbook-2026; proteostasis-ms2
LAMTOR2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Ragulator complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	ok_for_propagation_to_go	GO:0071986	Ragulator complex	LAMTOR1;LAMTOR2;LAMTOR3;LAMTOR4;LAMTOR5		already_in_goa_exact	GO:0071986 Ragulator complex	This PN leaf is restricted to Ragulator complex subunits. The matching GO cellular-component term is Ragulator complex.		proteostasis-workbook-2026; proteostasis-ms2
LAMTOR3		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Ragulator complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	ok_for_propagation_to_go	GO:0071986	Ragulator complex	LAMTOR1;LAMTOR2;LAMTOR3;LAMTOR4;LAMTOR5		already_in_goa_exact	GO:0071986 Ragulator complex	This PN leaf is restricted to Ragulator complex subunits. The matching GO cellular-component term is Ragulator complex.		proteostasis-workbook-2026; proteostasis-ms2
LAMTOR4		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Ragulator complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	ok_for_propagation_to_go	GO:0071986	Ragulator complex	LAMTOR1;LAMTOR2;LAMTOR3;LAMTOR4;LAMTOR5		already_in_goa_exact	GO:0071986 Ragulator complex	This PN leaf is restricted to Ragulator complex subunits. The matching GO cellular-component term is Ragulator complex.		proteostasis-workbook-2026; proteostasis-ms2
LAMTOR5		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Ragulator complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Ragulator complex component	ok_for_propagation_to_go	GO:0071986	Ragulator complex	LAMTOR1;LAMTOR2;LAMTOR3;LAMTOR4;LAMTOR5		already_in_goa_exact	GO:0071986 Ragulator complex	This PN leaf is restricted to Ragulator complex subunits. The matching GO cellular-component term is Ragulator complex.		proteostasis-workbook-2026; proteostasis-ms2
NPRL2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR1 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex component	ok_for_propagation_to_go	GO:1990130	GATOR1 complex	NPRL2;NPRL3;DEPDC5		already_in_goa_exact	GO:1990130 GATOR1 complex	This PN subtype denotes component membership in the GATOR1 nutrient- sensing complex upstream of mTORC1 and autophagy control. Propagation to the GO cellular-component term for GATOR1 complex is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
NPRL3		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR1 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex component	ok_for_propagation_to_go	GO:1990130	GATOR1 complex	NPRL2;NPRL3;DEPDC5		already_in_goa_exact	GO:1990130 GATOR1 complex	This PN subtype denotes component membership in the GATOR1 nutrient- sensing complex upstream of mTORC1 and autophagy control. Propagation to the GO cellular-component term for GATOR1 complex is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
DEPDC5		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR1 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex component	ok_for_propagation_to_go	GO:1990130	GATOR1 complex	NPRL2;NPRL3;DEPDC5		already_in_goa_exact	GO:1990130 GATOR1 complex	This PN subtype denotes component membership in the GATOR1 nutrient- sensing complex upstream of mTORC1 and autophagy control. Propagation to the GO cellular-component term for GATOR1 complex is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
SAMTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex modulator	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR1 complex modulator	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex modulator	ok_for_propagation_to_go	GO:1990130	GATOR1 complex	SAMTOR		new_to_goa		This PN subtype is a GATOR1 complex modulator in the nutrient-sensing arm of mTORC1 control. Propagation to the GO GATOR1 complex term keeps the same nutrient-sensing mechanism.		proteostasis-workbook-2024; proteostasis-ms2
SEC13		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SEC13;SEH1L;WDR59;WDR24;MIOS		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype denotes component membership in the GATOR2 nutrient- sensing complex upstream of mTORC1 regulation. The matching GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SEH1L		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SEC13;SEH1L;WDR59;WDR24;MIOS		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype denotes component membership in the GATOR2 nutrient- sensing complex upstream of mTORC1 regulation. The matching GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
WDR59		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SEC13;SEH1L;WDR59;WDR24;MIOS		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype denotes component membership in the GATOR2 nutrient- sensing complex upstream of mTORC1 regulation. The matching GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
WDR24		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SEC13;SEH1L;WDR59;WDR24;MIOS		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype denotes component membership in the GATOR2 nutrient- sensing complex upstream of mTORC1 regulation. The matching GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
MIOS		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex component	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SEC13;SEH1L;WDR59;WDR24;MIOS		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype denotes component membership in the GATOR2 nutrient- sensing complex upstream of mTORC1 regulation. The matching GO cellular-component term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SAR1B		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex modulator	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SAR1B;SESN1;SESN2;SESN3		new_to_goa		This PN subtype is a GATOR2 complex modulator in the same upstream nutrient-sensing module. The GO GATOR2 complex term is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SESN1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex modulator	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SAR1B;SESN1;SESN2;SESN3		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype is a GATOR2 complex modulator in the same upstream nutrient-sensing module. The GO GATOR2 complex term is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SESN2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex modulator	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SAR1B;SESN1;SESN2;SESN3		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype is a GATOR2 complex modulator in the same upstream nutrient-sensing module. The GO GATOR2 complex term is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SESN3		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	GATOR2 complex modulator	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	SAR1B;SESN1;SESN2;SESN3		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN subtype is a GATOR2 complex modulator in the same upstream nutrient-sensing module. The GO GATOR2 complex term is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
KPTN		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	KICSTOR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	ok_for_propagation_to_go	GO:0140007	KICSTOR complex	KPTN;ITFG2;KICS2;SZT2		already_in_goa_exact	GO:0140007 KICSTOR complex	This PN leaf is a component bucket for the KICSTOR nutrient-sensing complex. The GO KICSTOR complex term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ITFG2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	KICSTOR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	ok_for_propagation_to_go	GO:0140007	KICSTOR complex	KPTN;ITFG2;KICS2;SZT2		already_in_goa_exact	GO:0140007 KICSTOR complex	This PN leaf is a component bucket for the KICSTOR nutrient-sensing complex. The GO KICSTOR complex term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
KICS2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	KICSTOR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	ok_for_propagation_to_go	GO:0140007	KICSTOR complex	KPTN;ITFG2;KICS2;SZT2		already_in_goa_exact	GO:0140007 KICSTOR complex	This PN leaf is a component bucket for the KICSTOR nutrient-sensing complex. The GO KICSTOR complex term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
SZT2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	KICSTOR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|KICSTOR complex component	ok_for_propagation_to_go	GO:0140007	KICSTOR complex	KPTN;ITFG2;KICS2;SZT2		already_in_goa_exact	GO:0140007 KICSTOR complex	This PN leaf is a component bucket for the KICSTOR nutrient-sensing complex. The GO KICSTOR complex term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0A1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0A2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
TCIRG1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0A4		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0B		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033176 proton-transporting V-type ATPase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0C		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033176 proton-transporting V-type ATPase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0033179 proton-transporting V-type ATPase, V0 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex;GO:0098588 bounding membrane of organelle	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0D1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0032991 protein-containing complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0D2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0E1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0E2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN leaf is restricted to V0-sector lysosomal V-ATPase components. The GO lysosomal V0-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1A		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0016020 membrane;GO:0016469 proton-transporting two-sector ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1B1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1B2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1C1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016469 proton-transporting two-sector ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1C2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1D		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033176 proton-transporting V-type ATPase complex;GO:0046611 lysosomal proton-transporting V-type ATPase complex	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1E1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0016469 proton-transporting two-sector ATPase complex;GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1E2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0005774 vacuolar membrane;GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1F		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1G1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1G2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1G3		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V1H		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		more_specific_than_existing_goa	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane	This PN leaf is restricted to V1-sector lysosomal V-ATPase components. The GO lysosomal V1-domain component term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6AP1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	ok_for_propagation_to_go	GO:0060590	ATPase regulator activity	ATP6AP1;ATP6AP2		new_to_goa		This PN leaf contains ATP6AP-family regulators of the lysosomal V-ATPase. ATPase regulator activity is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6AP2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, upstream	Nutrient sensing	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	ok_for_propagation_to_go	GO:0060590	ATPase regulator activity	ATP6AP1;ATP6AP2		new_to_goa		This PN leaf contains ATP6AP-family regulators of the lysosomal V-ATPase. ATPase regulator activity is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
MTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		already_in_goa_exact	GO:0031931 TORC1 complex	This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
RPTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		already_in_goa_exact	GO:0031931 TORC1 complex	This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
MLST8		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		already_in_goa_exact	GO:0031931 TORC1 complex	This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
AKT1S1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		already_in_goa_exact	GO:0031931 TORC1 complex	This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
DEPTOR		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		new_to_goa		This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
TTI1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		already_in_goa_exact	GO:0031931 TORC1 complex	This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
TELO2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	mTORC1 pathway, direct	mTORC1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	ok_for_propagation_to_go	GO:0031931	TORC1 complex	MTOR;RPTOR;MLST8;AKT1S1;DEPTOR		new_to_goa		This PN leaf is a component bucket for mTORC1/TORC1 machinery. The matching GO cellular-component target is TORC1 complex.		proteostasis-workbook-2026; proteostasis-ms2
PRKAA1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKAA2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKAB1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKAB2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKAG1		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKAG2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKAG3		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex component	ok_for_propagation_to_go	GO:0031588	nucleotide-activated protein kinase complex	PRKAA1;PRKAA2;PRKAB1;PRKAB2;PRKAG1		already_in_goa_exact	GO:0031588 nucleotide-activated protein kinase complex	This leaf is restricted to AMPK alpha, beta, and gamma subunits. The local GO cache uses nucleotide-activated protein kinase complex for this component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
PRKACA		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
PRKACB		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
PRKACG		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
PRKAR1A		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
PRKAR1B		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
PRKAR2A		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
PRKAR2B		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	PKA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|PKA complex component	ok_for_propagation_to_go	GO:0005952	cAMP-dependent protein kinase complex	PRKACA;PRKACB;PRKACG;PRKAR1A;PRKAR1B		already_in_goa_exact	GO:0005952 cAMP-dependent protein kinase complex	This leaf groups PKA catalytic and regulatory subunits. The shared GO assertion is cAMP-dependent protein kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHUK		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	IKK complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	ok_for_propagation_to_go	GO:0008385	IkappaB kinase complex	CHUK;IKBKB;IKBKG;MAP3K7		already_in_goa_exact	GO:0008385 IkappaB kinase complex	This leaf groups IKK-complex components in an AMPK/autophagy-signaling context. The shared GO assertion is IkappaB kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
IKBKB		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	IKK complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	ok_for_propagation_to_go	GO:0008385	IkappaB kinase complex	CHUK;IKBKB;IKBKG;MAP3K7		already_in_goa_exact	GO:0008385 IkappaB kinase complex	This leaf groups IKK-complex components in an AMPK/autophagy-signaling context. The shared GO assertion is IkappaB kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
IKBKG		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	IKK complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	ok_for_propagation_to_go	GO:0008385	IkappaB kinase complex	CHUK;IKBKB;IKBKG;MAP3K7		already_in_goa_exact	GO:0008385 IkappaB kinase complex	This leaf groups IKK-complex components in an AMPK/autophagy-signaling context. The shared GO assertion is IkappaB kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
MAP3K7		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	IKK complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	ok_for_propagation_to_go	GO:0008385	IkappaB kinase complex	CHUK;IKBKB;IKBKG;MAP3K7		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005829 cytosol	This leaf groups IKK-complex components in an AMPK/autophagy-signaling context. The shared GO assertion is IkappaB kinase complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CAMKK2		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|AMPK kinase (not in a complex)	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	AMPK kinase (not in a complex)	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|AMPK kinase (not in a complex)	ok_for_propagation_to_go	GO:0004674	protein serine/threonine kinase activity	CAMKK2;MAP3K7		already_in_goa_exact	GO:0004674 protein serine/threonine kinase activity	This leaf contains upstream kinases that phosphorylate AMPK. The defensible shared GO assertion is protein serine/threonine kinase activity, not direct regulation of autophagy.		proteostasis-workbook-2026; proteostasis-ms2
MAP3K7		Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|AMPK kinase (not in a complex)	Autophagy-Lysosome Pathway	Pre-initiation autophagy signaling	AMPK signaling pathway, direct	AMPK complex modulator by phosphorylation	AMPK kinase (not in a complex)	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|AMPK kinase (not in a complex)	ok_for_propagation_to_go	GO:0004674	protein serine/threonine kinase activity	CAMKK2;MAP3K7		already_in_goa_exact	GO:0004674 protein serine/threonine kinase activity	This leaf contains upstream kinases that phosphorylate AMPK. The defensible shared GO assertion is protein serine/threonine kinase activity, not direct regulation of autophagy.		proteostasis-workbook-2026; proteostasis-ms2
ULK1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ULK1 pathway, direct	ULK1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ok_for_propagation_to_go	GO:1990316	Atg1/ULK1 kinase complex	ULK1;ULK2;ULK3;ATG13;RB1CC1		already_in_goa_exact	GO:1990316 Atg1/ULK1 kinase complex	This PN leaf is a direct component class for the ULK1 initiation complex. The matching GO cellular-component term is Atg1/ULK1 kinase complex, and the core members already support that assignment in GOA.	This is the clean component-level mapping for the direct ULK1 initiation module; broader ULK1-pathway regulator leaves remain more contextual.	proteostasis-workbook-2024; proteostasis-ms2
ULK2		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ULK1 pathway, direct	ULK1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ok_for_propagation_to_go	GO:1990316	Atg1/ULK1 kinase complex	ULK1;ULK2;ULK3;ATG13;RB1CC1		more_specific_than_existing_goa	GO:0005737 cytoplasm	This PN leaf is a direct component class for the ULK1 initiation complex. The matching GO cellular-component term is Atg1/ULK1 kinase complex, and the core members already support that assignment in GOA.	This is the clean component-level mapping for the direct ULK1 initiation module; broader ULK1-pathway regulator leaves remain more contextual.	proteostasis-workbook-2024; proteostasis-ms2
ULK3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ULK1 pathway, direct	ULK1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ok_for_propagation_to_go	GO:1990316	Atg1/ULK1 kinase complex	ULK1;ULK2;ULK3;ATG13;RB1CC1		more_specific_than_existing_goa	GO:0005737 cytoplasm	This PN leaf is a direct component class for the ULK1 initiation complex. The matching GO cellular-component term is Atg1/ULK1 kinase complex, and the core members already support that assignment in GOA.	This is the clean component-level mapping for the direct ULK1 initiation module; broader ULK1-pathway regulator leaves remain more contextual.	proteostasis-workbook-2024; proteostasis-ms2
ATG13		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ULK1 pathway, direct	ULK1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ok_for_propagation_to_go	GO:1990316	Atg1/ULK1 kinase complex	ULK1;ULK2;ULK3;ATG13;RB1CC1		already_in_goa_exact	GO:1990316 Atg1/ULK1 kinase complex	This PN leaf is a direct component class for the ULK1 initiation complex. The matching GO cellular-component term is Atg1/ULK1 kinase complex, and the core members already support that assignment in GOA.	This is the clean component-level mapping for the direct ULK1 initiation module; broader ULK1-pathway regulator leaves remain more contextual.	proteostasis-workbook-2024; proteostasis-ms2
RB1CC1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ULK1 pathway, direct	ULK1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ok_for_propagation_to_go	GO:1990316	Atg1/ULK1 kinase complex	ULK1;ULK2;ULK3;ATG13;RB1CC1		already_in_goa_exact	GO:1990316 Atg1/ULK1 kinase complex	This PN leaf is a direct component class for the ULK1 initiation complex. The matching GO cellular-component term is Atg1/ULK1 kinase complex, and the core members already support that assignment in GOA.	This is the clean component-level mapping for the direct ULK1 initiation module; broader ULK1-pathway regulator leaves remain more contextual.	proteostasis-workbook-2024; proteostasis-ms2
ATG101		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ULK1 pathway, direct	ULK1 complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ok_for_propagation_to_go	GO:1990316	Atg1/ULK1 kinase complex	ULK1;ULK2;ULK3;ATG13;RB1CC1		already_in_goa_exact	GO:1990316 Atg1/ULK1 kinase complex	This PN leaf is a direct component class for the ULK1 initiation complex. The matching GO cellular-component term is Atg1/ULK1 kinase complex, and the core members already support that assignment in GOA.	This is the clean component-level mapping for the direct ULK1 initiation module; broader ULK1-pathway regulator leaves remain more contextual.	proteostasis-workbook-2024; proteostasis-ms2
PIK3C3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Class 3 PI3K complex 1, direct	Class 3 PI3K complex 1 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	ok_for_propagation_to_go	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PIK3C3;PIK3R4;BECN1;BECN2;ATG14		already_in_goa_exact	GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I	This PN type is a curated component class for the direct autophagy- promoting class III PI3K complex 1. Propagation to the matching GO cellular-component term is appropriate, although the source is a component-role category rather than the complex term itself.		proteostasis-workbook-2024; proteostasis-ms2
PIK3R4		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Class 3 PI3K complex 1, direct	Class 3 PI3K complex 1 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	ok_for_propagation_to_go	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PIK3C3;PIK3R4;BECN1;BECN2;ATG14		already_in_goa_exact	GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I	This PN type is a curated component class for the direct autophagy- promoting class III PI3K complex 1. Propagation to the matching GO cellular-component term is appropriate, although the source is a component-role category rather than the complex term itself.		proteostasis-workbook-2024; proteostasis-ms2
BECN1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Class 3 PI3K complex 1, direct	Class 3 PI3K complex 1 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	ok_for_propagation_to_go	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PIK3C3;PIK3R4;BECN1;BECN2;ATG14		already_in_goa_exact	GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I	This PN type is a curated component class for the direct autophagy- promoting class III PI3K complex 1. Propagation to the matching GO cellular-component term is appropriate, although the source is a component-role category rather than the complex term itself.		proteostasis-workbook-2024; proteostasis-ms2
BECN2		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Class 3 PI3K complex 1, direct	Class 3 PI3K complex 1 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	ok_for_propagation_to_go	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PIK3C3;PIK3R4;BECN1;BECN2;ATG14		already_in_goa_exact	GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I	This PN type is a curated component class for the direct autophagy- promoting class III PI3K complex 1. Propagation to the matching GO cellular-component term is appropriate, although the source is a component-role category rather than the complex term itself.		proteostasis-workbook-2024; proteostasis-ms2
ATG14		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Class 3 PI3K complex 1, direct	Class 3 PI3K complex 1 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	ok_for_propagation_to_go	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PIK3C3;PIK3R4;BECN1;BECN2;ATG14		more_specific_than_existing_goa	GO:0032991 protein-containing complex;GO:0035032 phosphatidylinositol 3-kinase complex, class III	This PN type is a curated component class for the direct autophagy- promoting class III PI3K complex 1. Propagation to the matching GO cellular-component term is appropriate, although the source is a component-role category rather than the complex term itself.		proteostasis-workbook-2024; proteostasis-ms2
RNF5		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Modulation of ATG4 activity	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, upstream	Preparation of ATG8 homologs for lipidation	Modulation of ATG4 activity	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Modulation of ATG4 activity	ok_for_propagation_to_go	GO:2000785	regulation of autophagosome assembly	RNF5		new_to_goa		This PN leaf denotes factors that alter ATG4 function upstream of ATG8 processing. The cleanest GO-level consequence captured in the current ontology is regulation of autophagosome assembly.	The PN label does not encode the sign of regulation, so the generic regulation term is safer than forcing a positive or negative subtype.	proteostasis-workbook-2024; proteostasis-ms2
ATG7		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Processing of ATG5-ATG12-ATG16 complex components	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, upstream	Preparation of ATG8 homologs for lipidation	Processing of ATG5-ATG12-ATG16 complex components	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Processing of ATG5-ATG12-ATG16 complex components	ok_for_propagation_to_go	GO:0032446	protein modification by small protein conjugation	ATG7;ATG10		already_in_goa_exact	GO:0032446 protein modification by small protein conjugation	This PN leaf groups the upstream processing/conjugation machinery that modifies components feeding into the ATG5-ATG12-ATG16 module. The strongest shared GO process target is protein modification by small protein conjugation.		proteostasis-workbook-2024; proteostasis-ms2
ATG10		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Processing of ATG5-ATG12-ATG16 complex components	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, upstream	Preparation of ATG8 homologs for lipidation	Processing of ATG5-ATG12-ATG16 complex components	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Processing of ATG5-ATG12-ATG16 complex components	ok_for_propagation_to_go	GO:0032446	protein modification by small protein conjugation	ATG7;ATG10		already_in_goa_exact	GO:0032446 protein modification by small protein conjugation	This PN leaf groups the upstream processing/conjugation machinery that modifies components feeding into the ATG5-ATG12-ATG16 module. The strongest shared GO process target is protein modification by small protein conjugation.		proteostasis-workbook-2024; proteostasis-ms2
MAP1LC3B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	ok_for_propagation_to_go	GO:0061739	protein lipidation involved in autophagosome assembly	MAP1LC3B;GABARAP;GABARAPL1		more_specific_than_existing_goa	GO:0000045 autophagosome assembly;GO:0006914 autophagy;GO:0016236 macroautophagy	This PN leaf denotes the ATG8-family proteins that are the direct substrates of the lipidation step during autophagophore growth. The best current GO target is the corresponding process term for protein lipidation in autophagosome assembly.	This is a substrate-class mapping to a process term, not a molecular activity mapping. It is safe because the leaf is specifically restricted to the ATG8 homologs being prepared for lipidation.	proteostasis-workbook-2024; proteostasis-ms2
GABARAP		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	ok_for_propagation_to_go	GO:0061739	protein lipidation involved in autophagosome assembly	MAP1LC3B;GABARAP;GABARAPL1		more_specific_than_existing_goa	GO:0000045 autophagosome assembly	This PN leaf denotes the ATG8-family proteins that are the direct substrates of the lipidation step during autophagophore growth. The best current GO target is the corresponding process term for protein lipidation in autophagosome assembly.	This is a substrate-class mapping to a process term, not a molecular activity mapping. It is safe because the leaf is specifically restricted to the ATG8 homologs being prepared for lipidation.	proteostasis-workbook-2024; proteostasis-ms2
GABARAPL1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	ok_for_propagation_to_go	GO:0061739	protein lipidation involved in autophagosome assembly	MAP1LC3B;GABARAP;GABARAPL1		more_specific_than_existing_goa	GO:0000045 autophagosome assembly	This PN leaf denotes the ATG8-family proteins that are the direct substrates of the lipidation step during autophagophore growth. The best current GO target is the corresponding process term for protein lipidation in autophagosome assembly.	This is a substrate-class mapping to a process term, not a molecular activity mapping. It is safe because the leaf is specifically restricted to the ATG8 homologs being prepared for lipidation.	proteostasis-workbook-2024; proteostasis-ms2
ATG12		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	ok_for_propagation_to_go	GO:0034274	Atg12-Atg5-Atg16 complex	ATG12;ATG5;ATG16L1;ATG16L2		already_in_goa_exact	GO:0034274 Atg12-Atg5-Atg16 complex	This PN subtype explicitly denotes a component of the E3-like ATG5-ATG12-ATG16 complex used in ATG8 lipidation. The matching GO cellular-component term for the Atg12-Atg5-Atg16 complex is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATG5		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	ok_for_propagation_to_go	GO:0034274	Atg12-Atg5-Atg16 complex	ATG12;ATG5;ATG16L1;ATG16L2		already_in_goa_exact	GO:0034274 Atg12-Atg5-Atg16 complex	This PN subtype explicitly denotes a component of the E3-like ATG5-ATG12-ATG16 complex used in ATG8 lipidation. The matching GO cellular-component term for the Atg12-Atg5-Atg16 complex is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATG16L1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	ok_for_propagation_to_go	GO:0034274	Atg12-Atg5-Atg16 complex	ATG12;ATG5;ATG16L1;ATG16L2		already_in_goa_exact	GO:0034274 Atg12-Atg5-Atg16 complex	This PN subtype explicitly denotes a component of the E3-like ATG5-ATG12-ATG16 complex used in ATG8 lipidation. The matching GO cellular-component term for the Atg12-Atg5-Atg16 complex is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATG16L2		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Component of E3-like ATG5-ATG12-ATG16 complex that transfers ATG8 to PE	ok_for_propagation_to_go	GO:0034274	Atg12-Atg5-Atg16 complex	ATG12;ATG5;ATG16L1;ATG16L2		already_in_goa_exact	GO:0034274 Atg12-Atg5-Atg16 complex	This PN subtype explicitly denotes a component of the E3-like ATG5-ATG12-ATG16 complex used in ATG8 lipidation. The matching GO cellular-component term for the Atg12-Atg5-Atg16 complex is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATG4A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Protease that removes C-terminal Arg from ATG8	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This leaf is restricted to ATG4-family proteases that process ATG8-family proteins before lipidation. GO lacks an ATG4-specific activity in the local cache, so cysteine-type peptidase activity is the safest shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ATG4B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Protease that removes C-terminal Arg from ATG8	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This leaf is restricted to ATG4-family proteases that process ATG8-family proteins before lipidation. GO lacks an ATG4-specific activity in the local cache, so cysteine-type peptidase activity is the safest shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ATG4C		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Protease that removes C-terminal Arg from ATG8	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This leaf is restricted to ATG4-family proteases that process ATG8-family proteins before lipidation. GO lacks an ATG4-specific activity in the local cache, so cysteine-type peptidase activity is the safest shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ATG4D		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	Protease that removes C-terminal Arg from ATG8	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|Protease that removes C-terminal Arg from ATG8	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This leaf is restricted to ATG4-family proteases that process ATG8-family proteins before lipidation. GO lacks an ATG4-specific activity in the local cache, so cysteine-type peptidase activity is the safest shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ATG3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|E2-like enzyme conjugated to ATG8 before transfer to PE	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Preparation of ATG8 homologs for lipidation	E2-like enzyme conjugated to ATG8 before transfer to PE	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|E2-like enzyme conjugated to ATG8 before transfer to PE	exact	GO:0141046	Atg8-family conjugating enzyme activity	ATG3		already_in_goa_exact	GO:0141046 Atg8-family conjugating enzyme activity	This PN leaf is an enzyme-role class for the E2-like factor that conjugates ATG8-family proteins before transfer to phosphatidylethanol- amine. The matching GO molecular function term is an exact fit.		proteostasis-workbook-2024; proteostasis-ms2
UCHL1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Deubiquitination of ATG8 homologs	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Deubiquitination of ATG8 homologs		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Deubiquitination of ATG8 homologs	ok_for_propagation_to_go	GO:0016579	protein deubiquitination	UCHL1;USP10		already_in_goa_exact	GO:0016579 protein deubiquitination	This PN type denotes deubiquitination of ATG8-family proteins within the autophagy pathway. GO does not currently provide an ATG8-specific deubiquitination term, so the defensible target is the broader parent process protein deubiquitination.	This mapping preserves the catalytic/process core shared by the member genes without claiming that all protein deubiquitination roles of those genes are autophagy-specific.	proteostasis-workbook-2024; proteostasis-ms2
USP10		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Deubiquitination of ATG8 homologs	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	ATG8 homolog processing, direct	Deubiquitination of ATG8 homologs		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Deubiquitination of ATG8 homologs	ok_for_propagation_to_go	GO:0016579	protein deubiquitination	UCHL1;USP10		already_in_goa_exact	GO:0016579 protein deubiquitination	This PN type denotes deubiquitination of ATG8-family proteins within the autophagy pathway. GO does not currently provide an ATG8-specific deubiquitination term, so the defensible target is the broader parent process protein deubiquitination.	This mapping preserves the catalytic/process core shared by the member genes without claiming that all protein deubiquitination roles of those genes are autophagy-specific.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC4		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC5		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC8		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC11		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC12		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		already_in_goa_exact	GO:0030008 TRAPP complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
TRAPPC13		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Autophagy component recruitment to autophagophore	TRAPP complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Autophagy component recruitment to autophagophore|TRAPP complex component	ok_for_propagation_to_go	GO:0030008	TRAPP complex	TRAPPC1;TRAPPC3;TRAPPC4;TRAPPC5;TRAPPC8		entailed_by_goa_closure	GO:1990072 TRAPPIII protein complex	This PN leaf is a curated component bucket for TRAPP subunits used in autophagophore recruitment. The matching GO cellular-component term is TRAPP complex, and the member genes already converge strongly on that assignment in existing GOA.	The PN leaf is autophagy-contextual, but the shared gene-level semantics are still cleanly captured by TRAPP complex membership.	proteostasis-workbook-2024; proteostasis-ms2
ATG2A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG2-WIPI complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ok_for_propagation_to_go	GO:0062079	ATG2-ATG18 complex	ATG2A;ATG2B;WIPI1;WIPI2;WDR45B		more_specific_than_existing_goa	GO:0000407 phagophore assembly site;GO:0034045 phagophore assembly site membrane	This PN component bucket corresponds to the ATG2-WIPI/ATG18 lipid-transfer complex used during autophagophore membrane expansion. The GO ATG2-ATG18 complex term is the closest component-level target.		proteostasis-workbook-2026; proteostasis-ms2
ATG2B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG2-WIPI complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ok_for_propagation_to_go	GO:0062079	ATG2-ATG18 complex	ATG2A;ATG2B;WIPI1;WIPI2;WDR45B		more_specific_than_existing_goa	GO:0000407 phagophore assembly site;GO:0034045 phagophore assembly site membrane	This PN component bucket corresponds to the ATG2-WIPI/ATG18 lipid-transfer complex used during autophagophore membrane expansion. The GO ATG2-ATG18 complex term is the closest component-level target.		proteostasis-workbook-2026; proteostasis-ms2
WIPI1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG2-WIPI complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ok_for_propagation_to_go	GO:0062079	ATG2-ATG18 complex	ATG2A;ATG2B;WIPI1;WIPI2;WDR45B		more_specific_than_existing_goa	GO:0000407 phagophore assembly site;GO:0005737 cytoplasm;GO:0034045 phagophore assembly site membrane	This PN component bucket corresponds to the ATG2-WIPI/ATG18 lipid-transfer complex used during autophagophore membrane expansion. The GO ATG2-ATG18 complex term is the closest component-level target.		proteostasis-workbook-2026; proteostasis-ms2
WIPI2		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG2-WIPI complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ok_for_propagation_to_go	GO:0062079	ATG2-ATG18 complex	ATG2A;ATG2B;WIPI1;WIPI2;WDR45B		more_specific_than_existing_goa	GO:0000407 phagophore assembly site;GO:0016020 membrane;GO:0032991 protein-containing complex;GO:0034045 phagophore assembly site membrane	This PN component bucket corresponds to the ATG2-WIPI/ATG18 lipid-transfer complex used during autophagophore membrane expansion. The GO ATG2-ATG18 complex term is the closest component-level target.		proteostasis-workbook-2026; proteostasis-ms2
WDR45B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG2-WIPI complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ok_for_propagation_to_go	GO:0062079	ATG2-ATG18 complex	ATG2A;ATG2B;WIPI1;WIPI2;WDR45B		more_specific_than_existing_goa	GO:0000407 phagophore assembly site;GO:0034045 phagophore assembly site membrane	This PN component bucket corresponds to the ATG2-WIPI/ATG18 lipid-transfer complex used during autophagophore membrane expansion. The GO ATG2-ATG18 complex term is the closest component-level target.		proteostasis-workbook-2026; proteostasis-ms2
WDR45		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG2-WIPI complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ok_for_propagation_to_go	GO:0062079	ATG2-ATG18 complex	ATG2A;ATG2B;WIPI1;WIPI2;WDR45B		more_specific_than_existing_goa	GO:0000407 phagophore assembly site;GO:0005737 cytoplasm;GO:0034045 phagophore assembly site membrane	This PN component bucket corresponds to the ATG2-WIPI/ATG18 lipid-transfer complex used during autophagophore membrane expansion. The GO ATG2-ATG18 complex term is the closest component-level target.		proteostasis-workbook-2026; proteostasis-ms2
ATG9A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG9 homolog	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG9 homolog		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG9 homolog	ok_for_propagation_to_go	GO:0017128	phospholipid scramblase activity	ATG9A;ATG9B		already_in_goa_exact	GO:0017128 phospholipid scramblase activity	This PN leaf is restricted to the ATG9-family proteins, and both human members already support phospholipid scramblase activity in GOA. That MF is the clearest shared mechanistic target exposed by the current ontology.	The PN leaf also carries membrane-source and localization context, but phospholipid scramblase activity is the most specific shared GO function across the leaf members.	proteostasis-workbook-2024; proteostasis-ms2
ATG9B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG9 homolog	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG9 homolog		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG9 homolog	ok_for_propagation_to_go	GO:0017128	phospholipid scramblase activity	ATG9A;ATG9B		already_in_goa_exact	GO:0017128 phospholipid scramblase activity	This PN leaf is restricted to the ATG9-family proteins, and both human members already support phospholipid scramblase activity in GOA. That MF is the clearest shared mechanistic target exposed by the current ontology.	The PN leaf also carries membrane-source and localization context, but phospholipid scramblase activity is the most specific shared GO function across the leaf members.	proteostasis-workbook-2024; proteostasis-ms2
VAMP7		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
VAMP7		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN subtype is a more specific ATG16L1-positive membrane-input node nested under the same membrane-repair mechanism. Propagation to the same GO target remains biologically centered and conservative.		proteostasis-workbook-2024; proteostasis-ms2
STX7		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
STX7		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN subtype is a more specific ATG16L1-positive membrane-input node nested under the same membrane-repair mechanism. Propagation to the same GO target remains biologically centered and conservative.		proteostasis-workbook-2024; proteostasis-ms2
STX8		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
STX8		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN subtype is a more specific ATG16L1-positive membrane-input node nested under the same membrane-repair mechanism. Propagation to the same GO target remains biologically centered and conservative.		proteostasis-workbook-2024; proteostasis-ms2
VTI1B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
VTI1B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN subtype is a more specific ATG16L1-positive membrane-input node nested under the same membrane-repair mechanism. Propagation to the same GO target remains biologically centered and conservative.		proteostasis-workbook-2024; proteostasis-ms2
VAMP3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
VAMP3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN subtype is a more specific ATG16L1-positive membrane-input node nested under the same membrane-repair mechanism. Propagation to the same GO target remains biologically centered and conservative.		proteostasis-workbook-2024; proteostasis-ms2
VAMP2		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
VAMP2		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN subtype is a more specific ATG16L1-positive membrane-input node nested under the same membrane-repair mechanism. Propagation to the same GO target remains biologically centered and conservative.		proteostasis-workbook-2024; proteostasis-ms2
PICALM		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex regulator	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	VAMP7;STX7;STX8;VTI1B;VAMP3		new_to_goa		This PN type captures the ATG16L1-linked plasma-membrane input to the autophagophore membrane pool. The source label is still centered on a membrane-repair / membrane-input mechanism, so propagation to positive regulation of plasma membrane repair is the safest supported GO target.		proteostasis-workbook-2024; proteostasis-ms2
PICALM		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ATG16L1-positive plasma membrane input	Autophagophore-vesicle SNARE complex regulator	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator	ok_for_propagation_to_go	GO:1905686	positive regulation of plasma membrane repair	PICALM		new_to_goa		This PN subtype denotes a regulatory role in the same ATG16L1-linked plasma-membrane input mechanism. The membrane-repair GO term is still the cleanest propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SEC13		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC31A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC31B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC23A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC23B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC23IP		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0012507 ER to Golgi transport vesicle membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC24A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC24B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC24C		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SEC24D		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SAR1A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
SAR1B		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	ER membrane input	COPII vesicle component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component	ok_for_propagation_to_go	GO:0030127	COPII vesicle coat	SEC13;SEC31A;SEC31B;SEC23A;SEC23B		already_in_goa_exact	GO:0030127 COPII vesicle coat	This PN leaf groups the core COPII coat machinery that contributes ER membrane input to autophagophore formation. The strongest shared GO cellular-component signal across the member genes is COPII vesicle coat.	The PN leaf is used here as a coat-component class, not as a generic ER to Golgi transport process bucket.	proteostasis-workbook-2024; proteostasis-ms2
MTMR3		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	Regulation of PI(3)P levels		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	ok_for_propagation_to_go	GO:0046856	phosphatidylinositol dephosphorylation	MTMR3;MTMR4;MTMR8;MTMR9;MTMR14		already_in_goa_exact	GO:0046856 phosphatidylinositol dephosphorylation	This PN leaf groups MTMR-family factors that reduce PI(3)P levels during autophagophore membrane regulation. The strongest shared GO process signal across the member genes is phosphatidylinositol dephosphorylation.	A process term is safer than forcing a catalytic phosphatase activity, because the leaf includes regulatory as well as catalytic MTMR family members.	proteostasis-workbook-2024; proteostasis-ms2
MTMR4		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	Regulation of PI(3)P levels		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	ok_for_propagation_to_go	GO:0046856	phosphatidylinositol dephosphorylation	MTMR3;MTMR4;MTMR8;MTMR9;MTMR14		already_in_goa_exact	GO:0046856 phosphatidylinositol dephosphorylation	This PN leaf groups MTMR-family factors that reduce PI(3)P levels during autophagophore membrane regulation. The strongest shared GO process signal across the member genes is phosphatidylinositol dephosphorylation.	A process term is safer than forcing a catalytic phosphatase activity, because the leaf includes regulatory as well as catalytic MTMR family members.	proteostasis-workbook-2024; proteostasis-ms2
MTMR8		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	Regulation of PI(3)P levels		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	ok_for_propagation_to_go	GO:0046856	phosphatidylinositol dephosphorylation	MTMR3;MTMR4;MTMR8;MTMR9;MTMR14		already_in_goa_exact	GO:0046856 phosphatidylinositol dephosphorylation	This PN leaf groups MTMR-family factors that reduce PI(3)P levels during autophagophore membrane regulation. The strongest shared GO process signal across the member genes is phosphatidylinositol dephosphorylation.	A process term is safer than forcing a catalytic phosphatase activity, because the leaf includes regulatory as well as catalytic MTMR family members.	proteostasis-workbook-2024; proteostasis-ms2
MTMR9		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	Regulation of PI(3)P levels		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	ok_for_propagation_to_go	GO:0046856	phosphatidylinositol dephosphorylation	MTMR3;MTMR4;MTMR8;MTMR9;MTMR14		already_in_goa_exact	GO:0046856 phosphatidylinositol dephosphorylation	This PN leaf groups MTMR-family factors that reduce PI(3)P levels during autophagophore membrane regulation. The strongest shared GO process signal across the member genes is phosphatidylinositol dephosphorylation.	A process term is safer than forcing a catalytic phosphatase activity, because the leaf includes regulatory as well as catalytic MTMR family members.	proteostasis-workbook-2024; proteostasis-ms2
MTMR14		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	Regulation of PI(3)P levels		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	ok_for_propagation_to_go	GO:0046856	phosphatidylinositol dephosphorylation	MTMR3;MTMR4;MTMR8;MTMR9;MTMR14		new_to_goa		This PN leaf groups MTMR-family factors that reduce PI(3)P levels during autophagophore membrane regulation. The strongest shared GO process signal across the member genes is phosphatidylinositol dephosphorylation.	A process term is safer than forcing a catalytic phosphatase activity, because the leaf includes regulatory as well as catalytic MTMR family members.	proteostasis-workbook-2024; proteostasis-ms2
ZFYVE1		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|PI(3)P sequestration	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	PI(3)P sequestration		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|PI(3)P sequestration	ok_for_propagation_to_go	GO:0032266	phosphatidylinositol-3-phosphate binding	ZFYVE1		already_in_goa_exact	GO:0032266 phosphatidylinositol-3-phosphate binding	This PN leaf denotes sequestration of PI(3)P at the nascent autophagophore membrane. The current single-gene member, ZFYVE1, already supports phosphatidylinositol-3-phosphate binding, which is the clearest shared GO function exposed by the ontology.	This captures the lipid-recognition mechanism behind the PN leaf rather than trying to force a more specific autophagy-stage process term.	proteostasis-workbook-2024; proteostasis-ms2
PI4KB		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|PI(4)P production	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	PI(4)P production		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|PI(4)P production	ok_for_propagation_to_go	GO:0004430	1-phosphatidylinositol 4-kinase activity	PI4KB		already_in_goa_exact	GO:0004430 1-phosphatidylinositol 4-kinase activity	This PN leaf denotes production of PI(4)P as a membrane-composition input to autophagophore formation. The member gene PI4KB already supports the matching catalytic GO molecular function 1-phosphatidylinositol 4-kinase activity.	The PN wording is process-like, but the current ontology expresses the clean reusable shared semantics most directly as the kinase activity.	proteostasis-workbook-2024; proteostasis-ms2
GRAMD1A		Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulates cholesterol transfer to autophagophore	Autophagy-Lysosome Pathway	Autophagophore initiation and elongation	Regulation of autophagophore membrane composition	Regulates cholesterol transfer to autophagophore		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulates cholesterol transfer to autophagophore	ok_for_propagation_to_go	GO:0120020	cholesterol transfer activity	GRAMD1A		already_in_goa_exact	GO:0120020 cholesterol transfer activity	This PN type is explicitly about cholesterol transfer into the autophagophore membrane system. The GO cholesterol transfer activity term preserves the core mechanism without overcommitting to a broader autophagy process term.		proteostasis-workbook-2024; proteostasis-ms2
PINK1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		already_in_goa_exact	GO:0000423 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
PARL		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901524 regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
PRKN		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		already_in_goa_exact	GO:0000423 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
PGAM5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		more_specific_than_existing_goa	GO:0016236 macroautophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
CLEC16A		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		already_in_goa_exact	GO:0000423 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
RNF41		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
USP8		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
MUL1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1905091 positive regulation of type 2 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
SIAH1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
SNCAIP		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
HK2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1905091 positive regulation of type 2 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
SLC25A4		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901526 positive regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
SLC25A5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901526 positive regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
SREBF1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901524 regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
SREBF2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901524 regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
VDAC1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901524 regulation of mitophagy;GO:1901526 positive regulation of mitophagy;GO:1905091 positive regulation of type 2 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
ATAD3A		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
IMMT		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
MARK2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		more_specific_than_existing_goa	GO:0000422 autophagy of mitochondrion	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
UBE2D2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Ubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
UBE2D3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Ubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
UBE2L3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Ubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
UBE2N		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Ubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
USP15		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Deubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
USP30		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Deubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901525 negative regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
USP35		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Deubiquitination of mitochondrial proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
TSPO		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Inhibits mitochondrial protein ubiquitination	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Inhibits mitochondrial protein ubiquitination	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901525 negative regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
NIPSNAP1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Recruitment of cargo adapters	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Recruitment of cargo adapters	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		already_in_goa_exact	GO:0000423 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
NIPSNAP2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Recruitment of cargo adapters	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Recruitment of cargo adapters	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		already_in_goa_exact	GO:0000423 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
HUWE1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Direct recruitment of AMBRA1	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Direct recruitment of AMBRA1	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1905091 positive regulation of type 2 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
MFN1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Modulator of mitochondrial morphology-induced mitophagy	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
MFN2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Modulator of mitochondrial morphology-induced mitophagy	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		entailed_by_goa_closure	GO:0061734 type 2 mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
DNM1L		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Modulator of mitochondrial morphology-induced mitophagy	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		supported_by_goa_regulation	GO:1901524 regulation of mitophagy	The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
PARK7		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Mitophagy	Modulator of mitochondrial morphology-induced mitophagy	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	PINK1;PARL;PRKN;PGAM5;CLEC16A		new_to_goa		The PN marking category for mitophagy captures upstream cargo-marking steps that commit mitochondrial substrates to the mitophagy pathway. That supports propagation to mitophagy.	ARIH1 is excluded after gene-level review because its complete review supports RBR E3 ubiquitin ligase activity in neddylated CRL assemblies but not a mitophagy-specific role. ATP5IF1 and TOMM7 are excluded from direct mitophagy propagation because their complete reviews support positive regulation of type 2 mitophagy/PINK1-Parkin signaling rather than direct execution of the mitophagy process.	proteostasis-workbook-2024; proteostasis-ms2; file:human/ARIH1/ARIH1-ai-review.yaml; file:human/ATP5IF1/ATP5IF1-ai-review.yaml; file:human/TOMM7/TOMM7-ai-review.yaml
TRIM13		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	Ubiquitination of ER proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13;DDRGK1;UFL1;UBA5;UFC1		new_to_goa		The PN ERphagy marking category captures factors that mark ER cargo for selective autophagic turnover. GO uses reticulophagy for this pathway, so propagation to reticulophagy is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
TRIM13		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	Ubiquitination of ER proteins	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13		new_to_goa		This PN subtype denotes ubiquitin-based marking of ER cargo within the ERphagy pathway. The subtype is one mechanistic route into reticulophagy rather than a separate GO process.		proteostasis-workbook-2024; proteostasis-ms2
DDRGK1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13;DDRGK1;UFL1;UBA5;UFC1		already_in_goa_exact	GO:0061709 reticulophagy	The PN ERphagy marking category captures factors that mark ER cargo for selective autophagic turnover. GO uses reticulophagy for this pathway, so propagation to reticulophagy is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
DDRGK1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	ok_for_propagation_to_go	GO:0061709	reticulophagy	DDRGK1;UFL1;UBA5;UFC1;UFM1		already_in_goa_exact	GO:0061709 reticulophagy	This PN subtype captures a specific ER-cargo marking mechanism used in ERphagy. Because GO uses reticulophagy for ER autophagy, this subtype can propagate to reticulophagy.		proteostasis-workbook-2024; proteostasis-ms2
UFL1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13;DDRGK1;UFL1;UBA5;UFC1		already_in_goa_exact	GO:0061709 reticulophagy	The PN ERphagy marking category captures factors that mark ER cargo for selective autophagic turnover. GO uses reticulophagy for this pathway, so propagation to reticulophagy is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
UFL1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	ok_for_propagation_to_go	GO:0061709	reticulophagy	DDRGK1;UFL1;UBA5;UFC1;UFM1		already_in_goa_exact	GO:0061709 reticulophagy	This PN subtype captures a specific ER-cargo marking mechanism used in ERphagy. Because GO uses reticulophagy for ER autophagy, this subtype can propagate to reticulophagy.		proteostasis-workbook-2024; proteostasis-ms2
UBA5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13;DDRGK1;UFL1;UBA5;UFC1		already_in_goa_exact	GO:0061709 reticulophagy	The PN ERphagy marking category captures factors that mark ER cargo for selective autophagic turnover. GO uses reticulophagy for this pathway, so propagation to reticulophagy is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
UBA5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	ok_for_propagation_to_go	GO:0061709	reticulophagy	DDRGK1;UFL1;UBA5;UFC1;UFM1		already_in_goa_exact	GO:0061709 reticulophagy	This PN subtype captures a specific ER-cargo marking mechanism used in ERphagy. Because GO uses reticulophagy for ER autophagy, this subtype can propagate to reticulophagy.		proteostasis-workbook-2024; proteostasis-ms2
UFC1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13;DDRGK1;UFL1;UBA5;UFC1		already_in_goa_exact	GO:0061709 reticulophagy	The PN ERphagy marking category captures factors that mark ER cargo for selective autophagic turnover. GO uses reticulophagy for this pathway, so propagation to reticulophagy is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
UFC1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	ok_for_propagation_to_go	GO:0061709	reticulophagy	DDRGK1;UFL1;UBA5;UFC1;UFM1		already_in_goa_exact	GO:0061709 reticulophagy	This PN subtype captures a specific ER-cargo marking mechanism used in ERphagy. Because GO uses reticulophagy for ER autophagy, this subtype can propagate to reticulophagy.		proteostasis-workbook-2024; proteostasis-ms2
UFM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	TRIM13;DDRGK1;UFL1;UBA5;UFC1		already_in_goa_exact	GO:0061709 reticulophagy	The PN ERphagy marking category captures factors that mark ER cargo for selective autophagic turnover. GO uses reticulophagy for this pathway, so propagation to reticulophagy is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
UFM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	ERphagy	UFMylation of ER proteins	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|UFMylation of ER proteins	ok_for_propagation_to_go	GO:0061709	reticulophagy	DDRGK1;UFL1;UBA5;UFC1;UFM1		already_in_goa_exact	GO:0061709 reticulophagy	This PN subtype captures a specific ER-cargo marking mechanism used in ERphagy. Because GO uses reticulophagy for ER autophagy, this subtype can propagate to reticulophagy.		proteostasis-workbook-2024; proteostasis-ms2
PEX5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Pexophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Pexophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Pexophagy	ok_for_propagation_to_go	GO:0000425	pexophagy	PEX5		already_in_goa_exact	GO:0000425 pexophagy	This PN type captures substrate-marking steps specific to pexophagy. The source category is a mechanistic substep within the pexophagy pathway.		proteostasis-workbook-2024; proteostasis-ms2
VCP		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	VCP		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This PN type captures lysophagy cargo-marking factors that recruit damaged lysosomal material into autophagic clearance. In the current GO cache, autophagy cargo adaptor activity is the narrowest supported target.		proteostasis-workbook-2024; proteostasis-ms2
VCP		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy|ELDR complex component	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	VCP		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	The PN ELDR-complex subtype sits inside lysophagy cargo-marking machinery. In the current GO cache, autophagy cargo adaptor activity is the narrowest supported target for this lysophagy-specific adaptor role.		proteostasis-workbook-2024; proteostasis-ms2
LRSAM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Intracellular pathogen ubiquitination	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Xenophagy	Intracellular pathogen ubiquitination	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	LRSAM1;PHF23;RNF166		supported_by_goa_regulation	GO:1904417 positive regulation of xenophagy	This PN type groups xenophagy-specific marking steps that label cargo for selective autophagic clearance. That is narrower than, but clearly inside, the xenophagy process.		proteostasis-workbook-2024; proteostasis-ms2
PHF23		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Suppressor of intracellular pathogen ubiquitination	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Xenophagy	Suppressor of intracellular pathogen ubiquitination	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	LRSAM1;PHF23;RNF166		new_to_goa		This PN type groups xenophagy-specific marking steps that label cargo for selective autophagic clearance. That is narrower than, but clearly inside, the xenophagy process.		proteostasis-workbook-2024; proteostasis-ms2
RNF166		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Catalyzes K33-linked ubiquitination of p62	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Xenophagy	Catalyzes K33-linked ubiquitination of p62	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	LRSAM1;PHF23;RNF166		new_to_goa		This PN type groups xenophagy-specific marking steps that label cargo for selective autophagic clearance. That is narrower than, but clearly inside, the xenophagy process.		proteostasis-workbook-2024; proteostasis-ms2
AUP1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Ubiquitination of lipid droplet surface proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lipophagy	Ubiquitination of lipid droplet surface proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	ok_for_propagation_to_go	GO:0061724	lipophagy	AUP1;UBE2G2;RAB7A;RAB7B;ADRB2		already_in_goa_exact	GO:0061724 lipophagy	This PN type denotes factors that mark lipid cargo for selective autophagy. The category is narrower than the full lipophagy process, so propagation scope is the correct fit.		proteostasis-workbook-2024; proteostasis-ms2
UBE2G2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Ubiquitination of lipid droplet surface proteins	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lipophagy	Ubiquitination of lipid droplet surface proteins	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	ok_for_propagation_to_go	GO:0061724	lipophagy	AUP1;UBE2G2;RAB7A;RAB7B;ADRB2		new_to_goa		This PN type denotes factors that mark lipid cargo for selective autophagy. The category is narrower than the full lipophagy process, so propagation scope is the correct fit.		proteostasis-workbook-2024; proteostasis-ms2
RAB7A		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Recruiting autophagy factors to lipid droplets	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lipophagy	Recruiting autophagy factors to lipid droplets	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	ok_for_propagation_to_go	GO:0061724	lipophagy	AUP1;UBE2G2;RAB7A;RAB7B;ADRB2		already_in_goa_exact	GO:0061724 lipophagy	This PN type denotes factors that mark lipid cargo for selective autophagy. The category is narrower than the full lipophagy process, so propagation scope is the correct fit.		proteostasis-workbook-2024; proteostasis-ms2
RAB7B		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Recruiting autophagy factors to lipid droplets	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lipophagy	Recruiting autophagy factors to lipid droplets	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	ok_for_propagation_to_go	GO:0061724	lipophagy	AUP1;UBE2G2;RAB7A;RAB7B;ADRB2		new_to_goa		This PN type denotes factors that mark lipid cargo for selective autophagy. The category is narrower than the full lipophagy process, so propagation scope is the correct fit.		proteostasis-workbook-2024; proteostasis-ms2
ADRB2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Upstream lipophagy signaling	Autophagy-Lysosome Pathway	Autophagy substrate selection	Marking substrates for selective autophagy	Lipophagy	Upstream lipophagy signaling	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	ok_for_propagation_to_go	GO:0061724	lipophagy	AUP1;UBE2G2;RAB7A;RAB7B;ADRB2		supported_by_goa_regulation	GO:1904504 positive regulation of lipophagy	This PN type denotes factors that mark lipid cargo for selective autophagy. The category is narrower than the full lipophagy process, so propagation scope is the correct fit.		proteostasis-workbook-2024; proteostasis-ms2
SQSTM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		already_in_goa_exact	GO:0000423 mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
OPTN		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		entailed_by_goa_closure	GO:0061734 type 2 mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
CALCOCO2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
TAX1BP1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
FUNDC1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		already_in_goa_exact	GO:0000423 mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
BCL2L13		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
FKBP8		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		supported_by_goa_regulation	GO:1901524 regulation of mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
PHB2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		already_in_goa_exact	GO:0000423 mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
NLRX1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
TUFM		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
MAP1S		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		more_specific_than_existing_goa	GO:0006914 autophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
TBC1D15		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
TBC1D17		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		new_to_goa		This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
BNIP3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		already_in_goa_exact	GO:0000423 mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
BNIP3L		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;FUNDC1		supported_by_goa_regulation	GO:1901524 regulation of mitophagy	This PN path denotes selective-autophagy receptors for mitochondrial cargo. The source category is a mechanistic sub-role within mitophagy, so propagation rather than exact equivalence is the correct scope.		proteostasis-workbook-2024; proteostasis-ms2
RETREG1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		already_in_goa_exact	GO:0061709 reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
RETREG2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		new_to_goa		The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
RETREG3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		already_in_goa_exact	GO:0061709 reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
SEC62		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		already_in_goa_exact	GO:0061709 reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
RTN3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		already_in_goa_exact	GO:0061709 reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
CCPG1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		already_in_goa_exact	GO:0061709 reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
ATL3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		new_to_goa		The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
TEX264		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		already_in_goa_exact	GO:0061709 reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
CALCOCO1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		new_to_goa		The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
CDK5RAP3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	ERphagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	ok_for_propagation_to_go	GO:0061709	reticulophagy	RETREG1;RETREG2;RETREG3;SEC62;RTN3		supported_by_goa_regulation	GO:0140501 positive regulation of reticulophagy	The PN uses the community label ERphagy for selective autophagy of the endoplasmic reticulum, while GO uses the synonym reticulophagy. Receptor members of this PN category are suitable for propagation to the GO reticulophagy process.	GO uses reticulophagy rather than ERphagy for this process.	proteostasis-workbook-2024; proteostasis-ms2
SQSTM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Pexophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	ok_for_propagation_to_go	GO:0000425	pexophagy	SQSTM1;NBR1;PJVK		already_in_goa_exact	GO:0000425 pexophagy	This PN path groups receptors for selective autophagic turnover of peroxisomes. The role is part of, but not equivalent to, the full GO pexophagy process, so propagation scope is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
NBR1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Pexophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	ok_for_propagation_to_go	GO:0000425	pexophagy	SQSTM1;NBR1;PJVK		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN path groups receptors for selective autophagic turnover of peroxisomes. The role is part of, but not equivalent to, the full GO pexophagy process, so propagation scope is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
CALCOCO2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Lysophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	CALCOCO2;TRIM16		new_to_goa		The PN lysophagy receptor class denotes factors that recognize damaged lysosomal cargo and couple it to autophagic clearance. Since the current GO cache lacks a dedicated lysophagy process term, autophagy cargo adaptor activity is the most specific supported target.		proteostasis-workbook-2024; proteostasis-ms2
TRIM16		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Lysophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	CALCOCO2;TRIM16		new_to_goa		The PN lysophagy receptor class denotes factors that recognize damaged lysosomal cargo and couple it to autophagic clearance. Since the current GO cache lacks a dedicated lysophagy process term, autophagy cargo adaptor activity is the most specific supported target.		proteostasis-workbook-2024; proteostasis-ms2
PJVK		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Pexophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	ok_for_propagation_to_go	GO:0000425	pexophagy	SQSTM1;NBR1;PJVK		already_in_goa_exact	GO:0000425 pexophagy	This PN path groups receptors for selective autophagic turnover of peroxisomes. The role is part of, but not equivalent to, the full GO pexophagy process, so propagation scope is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
LMNB1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Nucleophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Nucleophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Nucleophagy	ok_for_propagation_to_go	GO:0044804	nucleophagy	LMNB1		new_to_goa		Receptors in this PN category participate specifically in selective autophagic turnover of nuclear material. That supports propagation to the GO nucleophagy process even though the PN source is receptor-centric.		proteostasis-workbook-2024; proteostasis-ms2
SQSTM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;TRIM5		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This PN category captures receptors for selective autophagy of pathogens or pathogen-derived material. The receptor class is narrower than the GO xenophagy process, so this is a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms2
OPTN		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;TRIM5		supported_by_goa_regulation	GO:1904417 positive regulation of xenophagy	This PN category captures receptors for selective autophagy of pathogens or pathogen-derived material. The receptor class is narrower than the GO xenophagy process, so this is a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms2
CALCOCO2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;TRIM5		already_in_goa_exact	GO:0098792 xenophagy	This PN category captures receptors for selective autophagy of pathogens or pathogen-derived material. The receptor class is narrower than the GO xenophagy process, so this is a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms2
TAX1BP1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;TRIM5		new_to_goa		This PN category captures receptors for selective autophagy of pathogens or pathogen-derived material. The receptor class is narrower than the GO xenophagy process, so this is a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms2
TRIM5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	SQSTM1;OPTN;CALCOCO2;TAX1BP1;TRIM5		more_specific_than_existing_goa	GO:0006914 autophagy	This PN category captures receptors for selective autophagy of pathogens or pathogen-derived material. The receptor class is narrower than the GO xenophagy process, so this is a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms2
SQSTM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Aggrephagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	ok_for_propagation_to_go	GO:0035973	aggrephagy	SQSTM1;NBR1;OPTN;TOLLIP;MAP1S		already_in_goa_exact	GO:0035973 aggrephagy	This PN path denotes receptors that recognize aggregation cargo for the aggrephagy pathway. The category is not identical to the GO process term, but propagation to aggrephagy is appropriate because membership in this receptor class implies direct participation in that process.	Process-propagation mapping from a receptor-role category to the matching selective autophagy process.	proteostasis-workbook-2024; proteostasis-ms2
NBR1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Aggrephagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	ok_for_propagation_to_go	GO:0035973	aggrephagy	SQSTM1;NBR1;OPTN;TOLLIP;MAP1S		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN path denotes receptors that recognize aggregation cargo for the aggrephagy pathway. The category is not identical to the GO process term, but propagation to aggrephagy is appropriate because membership in this receptor class implies direct participation in that process.	Process-propagation mapping from a receptor-role category to the matching selective autophagy process.	proteostasis-workbook-2024; proteostasis-ms2
OPTN		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Aggrephagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	ok_for_propagation_to_go	GO:0035973	aggrephagy	SQSTM1;NBR1;OPTN;TOLLIP;MAP1S		new_to_goa		This PN path denotes receptors that recognize aggregation cargo for the aggrephagy pathway. The category is not identical to the GO process term, but propagation to aggrephagy is appropriate because membership in this receptor class implies direct participation in that process.	Process-propagation mapping from a receptor-role category to the matching selective autophagy process.	proteostasis-workbook-2024; proteostasis-ms2
TOLLIP		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Aggrephagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	ok_for_propagation_to_go	GO:0035973	aggrephagy	SQSTM1;NBR1;OPTN;TOLLIP;MAP1S		new_to_goa		This PN path denotes receptors that recognize aggregation cargo for the aggrephagy pathway. The category is not identical to the GO process term, but propagation to aggrephagy is appropriate because membership in this receptor class implies direct participation in that process.	Process-propagation mapping from a receptor-role category to the matching selective autophagy process.	proteostasis-workbook-2024; proteostasis-ms2
MAP1S		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Aggrephagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	ok_for_propagation_to_go	GO:0035973	aggrephagy	SQSTM1;NBR1;OPTN;TOLLIP;MAP1S		more_specific_than_existing_goa	GO:0006914 autophagy	This PN path denotes receptors that recognize aggregation cargo for the aggrephagy pathway. The category is not identical to the GO process term, but propagation to aggrephagy is appropriate because membership in this receptor class implies direct participation in that process.	Process-propagation mapping from a receptor-role category to the matching selective autophagy process.	proteostasis-workbook-2024; proteostasis-ms2
STBD1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Glycophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Glycophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Glycophagy	ok_for_propagation_to_go	GO:0061723	glycophagy	STBD1		already_in_goa_exact	GO:0061723 glycophagy	This PN path groups receptors dedicated to selective glycogen autophagy. The receptor role is narrower than the full pathway, but members of this class can reasonably propagate to the GO glycophagy process.		proteostasis-workbook-2024; proteostasis-ms2
NUFIP1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ribophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Ribophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ribophagy	ok_for_propagation_to_go	GO:0034517	ribophagy	NUFIP1		new_to_goa		The PN category covers receptors for autophagic turnover of ribosomes. These genes belong in the ribophagy process, but the PN label denotes a receptor role rather than the entire process class.		proteostasis-workbook-2024; proteostasis-ms2
NCOA4		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ferritinophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Ferritinophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ferritinophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	NCOA4		more_specific_than_existing_goa	GO:0006914 autophagy	The PN ferritinophagy receptor category captures factors such as NCOA4 that bind ferritin cargo and recruit the autophagy machinery. GO does not currently provide a dedicated ferritinophagy process term in the local ontology cache, so autophagy cargo adaptor activity is the narrowest defensible target.	Chosen as an activity-level fallback because a ferritinophagy process term is absent from the current GO cache used for validation.	proteostasis-workbook-2024; proteostasis-ms2
RAB26		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Synaptophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Synaptophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Synaptophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	RAB26		new_to_goa		The PN synaptophagy receptor category includes factors that recruit synaptic cargo to autophagosomes. Because the validated GO cache has no dedicated synaptophagy process term, autophagy cargo adaptor activity is the narrowest current target that preserves the receptor semantics.		proteostasis-workbook-2024; proteostasis-ms2
SQSTM1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Midbody autophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	SQSTM1;NBR1;TRIM17		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy;GO:0030674 protein-macromolecule adaptor activity	Midbody-autophagy receptors such as SQSTM1 link ubiquitinated midbody material to the autophagy machinery. GO does not currently expose a dedicated midbody-autophagy process term in the local ontology cache, so the receptor activity term is the best available mapping target.		proteostasis-workbook-2024; proteostasis-ms2
NBR1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Midbody autophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	SQSTM1;NBR1;TRIM17		more_specific_than_existing_goa	GO:0016236 macroautophagy	Midbody-autophagy receptors such as SQSTM1 link ubiquitinated midbody material to the autophagy machinery. GO does not currently expose a dedicated midbody-autophagy process term in the local ontology cache, so the receptor activity term is the best available mapping target.		proteostasis-workbook-2024; proteostasis-ms2
TRIM17		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Midbody autophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	SQSTM1;NBR1;TRIM17		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0030674 protein-macromolecule adaptor activity	Midbody-autophagy receptors such as SQSTM1 link ubiquitinated midbody material to the autophagy machinery. GO does not currently expose a dedicated midbody-autophagy process term in the local ontology cache, so the receptor activity term is the best available mapping target.		proteostasis-workbook-2024; proteostasis-ms2
MEFV		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Individual substrates		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	MEFV;CCDC50		new_to_goa		This PN category groups receptors such as TRIM-family factors that bind specific substrates and recruit autophagy components for their turnover. That aligns best with autophagy cargo adaptor activity rather than with a single selective-autophagy process term.		proteostasis-workbook-2024; proteostasis-ms2
CCDC50		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Individual substrates		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	MEFV;CCDC50		new_to_goa		This PN category groups receptors such as TRIM-family factors that bind specific substrates and recruit autophagy components for their turnover. That aligns best with autophagy cargo adaptor activity rather than with a single selective-autophagy process term.		proteostasis-workbook-2024; proteostasis-ms2
HSPA8		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Chaperone assisted selective autophagy	CASA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	ok_for_propagation_to_go	GO:0035973	aggrephagy	HSPA8;BAG3;HSPB8;STUB1		new_to_goa		The PN CASA subtype covers BAG3-HSPB8-HSP70-system machinery that directs damaged or aggregation-prone substrates into selective autophagic clearance. GO lacks a dedicated CASA term in the current cache, and this subtype includes chaperones and cofactors beyond pure cargo adaptors, so aggrephagy is the closest available process target.	Mapped to aggrephagy rather than autophagy cargo adaptor activity because the PN subtype includes mixed machinery roles, not only receptor/adaptor functions.	proteostasis-workbook-2024; proteostasis-ms2
BAG3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Chaperone assisted selective autophagy	CASA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	ok_for_propagation_to_go	GO:0035973	aggrephagy	HSPA8;BAG3;HSPB8;STUB1		supported_by_goa_regulation	GO:1905337 positive regulation of aggrephagy	The PN CASA subtype covers BAG3-HSPB8-HSP70-system machinery that directs damaged or aggregation-prone substrates into selective autophagic clearance. GO lacks a dedicated CASA term in the current cache, and this subtype includes chaperones and cofactors beyond pure cargo adaptors, so aggrephagy is the closest available process target.	Mapped to aggrephagy rather than autophagy cargo adaptor activity because the PN subtype includes mixed machinery roles, not only receptor/adaptor functions.	proteostasis-workbook-2024; proteostasis-ms2
HSPB8		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Chaperone assisted selective autophagy	CASA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	ok_for_propagation_to_go	GO:0035973	aggrephagy	HSPA8;BAG3;HSPB8;STUB1		supported_by_goa_regulation	GO:1905337 positive regulation of aggrephagy	The PN CASA subtype covers BAG3-HSPB8-HSP70-system machinery that directs damaged or aggregation-prone substrates into selective autophagic clearance. GO lacks a dedicated CASA term in the current cache, and this subtype includes chaperones and cofactors beyond pure cargo adaptors, so aggrephagy is the closest available process target.	Mapped to aggrephagy rather than autophagy cargo adaptor activity because the PN subtype includes mixed machinery roles, not only receptor/adaptor functions.	proteostasis-workbook-2024; proteostasis-ms2
STUB1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Selective autophagy receptor	Chaperone assisted selective autophagy	CASA complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	ok_for_propagation_to_go	GO:0035973	aggrephagy	HSPA8;BAG3;HSPB8;STUB1		new_to_goa		The PN CASA subtype covers BAG3-HSPB8-HSP70-system machinery that directs damaged or aggregation-prone substrates into selective autophagic clearance. GO lacks a dedicated CASA term in the current cache, and this subtype includes chaperones and cofactors beyond pure cargo adaptors, so aggrephagy is the closest available process target.	Mapped to aggrephagy rather than autophagy cargo adaptor activity because the PN subtype includes mixed machinery roles, not only receptor/adaptor functions.	proteostasis-workbook-2024; proteostasis-ms2
FBXO7		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy|PINK/PRKN pathway	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Mitophagy	PINK/PRKN pathway	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	FBXO7;VPS13D		more_specific_than_existing_goa	GO:0000422 autophagy of mitochondrion	This PN type groups substrate-selectivity regulators assigned to mitophagy. Those factors participate in mitophagy, but the PN category is more specific than the full process term.	SAMM50 is excluded after gene-level review because its complete review supports SAM complex beta-barrel insertase activity and SAM-MICOS/MIB organization, not direct participation in mitophagy or mitophagy substrate selectivity.	proteostasis-workbook-2024; proteostasis-ms2; file:human/SAMM50/SAMM50-ai-review.yaml
VPS13D		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy|Binding of ubiquitin-marked mitochondria	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Mitophagy	Binding of ubiquitin-marked mitochondria	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	FBXO7;VPS13D		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN type groups substrate-selectivity regulators assigned to mitophagy. Those factors participate in mitophagy, but the PN category is more specific than the full process term.	SAMM50 is excluded after gene-level review because its complete review supports SAM complex beta-barrel insertase activity and SAM-MICOS/MIB organization, not direct participation in mitophagy or mitophagy substrate selectivity.	proteostasis-workbook-2024; proteostasis-ms2; file:human/SAMM50/SAMM50-ai-review.yaml
PLAA		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	PLAA;YOD1;UBXN6		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN type denotes lysophagy selectivity regulators. Because the local GO cache does not expose a dedicated lysophagy term, autophagy cargo adaptor activity is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
PLAA		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	PLAA;YOD1;UBXN6		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN subtype denotes the ELDR-complex adaptor role in lysophagy selectivity control. The current GO cache does not provide a more specific lysophagy target than autophagy cargo adaptor activity.		proteostasis-workbook-2024; proteostasis-ms2
YOD1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	PLAA;YOD1;UBXN6		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN type denotes lysophagy selectivity regulators. Because the local GO cache does not expose a dedicated lysophagy term, autophagy cargo adaptor activity is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
YOD1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	PLAA;YOD1;UBXN6		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN subtype denotes the ELDR-complex adaptor role in lysophagy selectivity control. The current GO cache does not provide a more specific lysophagy target than autophagy cargo adaptor activity.		proteostasis-workbook-2024; proteostasis-ms2
UBXN6		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	PLAA;YOD1;UBXN6		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN type denotes lysophagy selectivity regulators. Because the local GO cache does not expose a dedicated lysophagy term, autophagy cargo adaptor activity is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms2
UBXN6		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Lysophagy	ELDR complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	ok_for_propagation_to_go	GO:0160247	autophagy cargo adaptor activity	PLAA;YOD1;UBXN6		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN subtype denotes the ELDR-complex adaptor role in lysophagy selectivity control. The current GO cache does not provide a more specific lysophagy target than autophagy cargo adaptor activity.		proteostasis-workbook-2024; proteostasis-ms2
ACBD5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Pexophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Pexophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Pexophagy	ok_for_propagation_to_go	GO:0000425	pexophagy	ACBD5		already_in_goa_exact	GO:0000425 pexophagy	This PN type denotes selectivity regulators that direct substrates into the pexophagy pathway. Propagation to pexophagy is justified, but the source label is narrower than the process itself.		proteostasis-workbook-2024; proteostasis-ms2
WDFY3		Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Aggrephagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Substrate selectivity regulator for selective autophagy	Aggrephagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Aggrephagy	ok_for_propagation_to_go	GO:0035973	aggrephagy	WDFY3		already_in_goa_exact	GO:0035973 aggrephagy	The PN substrate-selectivity-regulator type for aggrephagy captures factors that determine cargo choice within the aggrephagy pathway. The source label is a regulator sub-role, so propagation is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
BNIP1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	BNIP1;RNF185;MARCHF5;TBK1;TANK		new_to_goa		The PN receptor-regulation type for mitophagy captures factors that tune receptor activity within the mitophagy pathway. This supports propagation to mitophagy while preserving that the source is a regulatory sub-role.		proteostasis-workbook-2024; proteostasis-ms2
RNF185		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	BNIP1;RNF185;MARCHF5;TBK1;TANK		new_to_goa		The PN receptor-regulation type for mitophagy captures factors that tune receptor activity within the mitophagy pathway. This supports propagation to mitophagy while preserving that the source is a regulatory sub-role.		proteostasis-workbook-2024; proteostasis-ms2
MARCHF5		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	BNIP1;RNF185;MARCHF5;TBK1;TANK		new_to_goa		The PN receptor-regulation type for mitophagy captures factors that tune receptor activity within the mitophagy pathway. This supports propagation to mitophagy while preserving that the source is a regulatory sub-role.		proteostasis-workbook-2024; proteostasis-ms2
TBK1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	BNIP1;RNF185;MARCHF5;TBK1;TANK		more_specific_than_existing_goa	GO:0016236 macroautophagy	The PN receptor-regulation type for mitophagy captures factors that tune receptor activity within the mitophagy pathway. This supports propagation to mitophagy while preserving that the source is a regulatory sub-role.		proteostasis-workbook-2024; proteostasis-ms2
TANK		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	BNIP1;RNF185;MARCHF5;TBK1;TANK		new_to_goa		The PN receptor-regulation type for mitophagy captures factors that tune receptor activity within the mitophagy pathway. This supports propagation to mitophagy while preserving that the source is a regulatory sub-role.		proteostasis-workbook-2024; proteostasis-ms2
NAP1L1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	BNIP1;RNF185;MARCHF5;TBK1;TANK		new_to_goa		The PN receptor-regulation type for mitophagy captures factors that tune receptor activity within the mitophagy pathway. This supports propagation to mitophagy while preserving that the source is a regulatory sub-role.		proteostasis-workbook-2024; proteostasis-ms2
LGALS8		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	LGALS8;AZI2		already_in_goa_exact	GO:0098792 xenophagy	This PN type groups receptor-regulatory factors assigned to xenophagy. The source category sits inside the xenophagy mechanism rather than being equivalent to the full process.		proteostasis-workbook-2024; proteostasis-ms2
AZI2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagy receptor regulation	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	LGALS8;AZI2		new_to_goa		This PN type groups receptor-regulatory factors assigned to xenophagy. The source category sits inside the xenophagy mechanism rather than being equivalent to the full process.		proteostasis-workbook-2024; proteostasis-ms2
CALCOCO2		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagosome formation for selective autophagy	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	CALCOCO2;RABGEF1		new_to_goa		This PN type denotes the autophagosome-formation machinery used specifically for mitophagy. The source is a mechanistic substep within the broader mitophagy process, so propagation rather than strict equivalence is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
RABGEF1		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagosome formation for selective autophagy	Mitophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy	ok_for_propagation_to_go	GO:0000423	mitophagy	CALCOCO2;RABGEF1		new_to_goa		This PN type denotes the autophagosome-formation machinery used specifically for mitophagy. The source is a mechanistic substep within the broader mitophagy process, so propagation rather than strict equivalence is appropriate.		proteostasis-workbook-2024; proteostasis-ms2
RAB17		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagosome formation for selective autophagy	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	RAB17;RAB23		new_to_goa		This PN type groups autophagosome-formation factors assigned to xenophagy. Those factors participate in the xenophagy pathway, but the PN label is narrower than the full GO process term.		proteostasis-workbook-2024; proteostasis-ms2
RAB23		Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway	Autophagy substrate selection	Autophagosome formation for selective autophagy	Xenophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	ok_for_propagation_to_go	GO:0098792	xenophagy	RAB17;RAB23		new_to_goa		This PN type groups autophagosome-formation factors assigned to xenophagy. Those factors participate in the xenophagy pathway, but the PN label is narrower than the full GO process term.		proteostasis-workbook-2024; proteostasis-ms2
TSG101		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
TSG101		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS28		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS28		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS37A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS37A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS37B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS37B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS37C		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS37C		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS37D		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS37D		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
MVB12A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
MVB12A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
MVB12B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		new_to_goa		This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
MVB12B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
UBAP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		new_to_goa		This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
UBAP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000813 ESCRT I complex	This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
UMAD1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		new_to_goa		This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
UMAD1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-I complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	ok_for_propagation_to_go	GO:0000813	ESCRT I complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C		new_to_goa		This leaf is restricted to ESCRT-I components used in autophagophore sealing. The shared GO assertion is ESCRT I complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP1A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP1A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP1B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP1B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP2A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP2A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP2B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP2B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP4A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP4A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP4B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP4B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP4C		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP4C		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP5		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP5		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
CHMP7		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CHMP7		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This PN type is a structural component class for ESCRT-III factors used in autophagophore sealing. The matching GO cellular-component term is ESCRT III complex, which is more precise than the broader late-fusion process mapping.		proteostasis-workbook-2024; proteostasis-ms2
VPS4A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex activity modulator		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0007033 vacuole organization;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS4B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex activity modulator		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0007033 vacuole organization;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
STX12		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex activity modulator		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000045 autophagosome assembly	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VTI1A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	ESCRT-III complex activity modulator		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0006914 autophagy;GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
PDCD6IP		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Localization of the ESCRT-III complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	Localization of the ESCRT-III complex		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VPS37A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Localization of the ESCRT-III complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	Localization of the ESCRT-III complex		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		more_specific_than_existing_goa	GO:0016236 macroautophagy	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
STX12		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Localization of the ESCRT-III complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	Localization of the ESCRT-III complex		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000045 autophagosome assembly	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
GABARAPL2		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Specific function in sealing of autophagophore membrane unknown	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	Specific function in sealing of autophagophore membrane unknown		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		already_in_goa_exact	GO:0000045 autophagosome assembly	This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CSNK1D		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Specific function in sealing of autophagophore membrane unknown	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Sealing of autophagophore membrane	Specific function in sealing of autophagophore membrane unknown		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	ok_for_propagation_to_go	GO:0000045	autophagosome assembly	TSG101;VPS28;VPS37A;VPS37B;VPS37C		new_to_goa		This group captures autophagophore closure/sealing, a late step in autophagosome assembly. Autophagosome assembly is the safer process target than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
MAP1LC3B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	ATG8 homolog	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
MAP1LC3B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	ATG8 homolog	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
MAP1LC3B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B		new_to_goa		This PN subtype specifically places ATG8-family proteins in the microtubule-dependent positioning of autophagosomes. The cleanest current GO process target is autophagosome localization.	This is a role-in-process propagation, not an assertion that ATG8 homologs are dedicated only to localization. The leaf is narrow enough that autophagosome localization is a defensible late-stage context term.	proteostasis-workbook-2024; proteostasis-ms2
RILP		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Recruitment of dynein-dynactin motor complex	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
RILP		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Recruitment of dynein-dynactin motor complex	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
RILP		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Recruitment of dynein-dynactin motor complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex	ok_for_propagation_to_go	GO:0061906	autophagosome localization	RILP		new_to_goa		This PN subtype captures recruitment of dynein-dynactin machinery for autophagosome movement. The mechanistically closest GO process target is autophagosome localization.		proteostasis-workbook-2024; proteostasis-ms2
ARL8A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
ARL8A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
ARL8A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ok_for_propagation_to_go	GO:0061906	autophagosome localization	ARL8A;ARL8B;RUFY3;RUFY4		new_to_goa		This PN subtype denotes the bridging machinery that links HOPS/BORC-like late-endolysosomal transport systems to autophagosome positioning on microtubules. The best current GO target is autophagosome localization.	This preserves the transport/positioning semantics of the leaf without collapsing it into broader axonal or lysosomal transport terms.	proteostasis-workbook-2024; proteostasis-ms2
ARL8B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
ARL8B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
ARL8B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ok_for_propagation_to_go	GO:0061906	autophagosome localization	ARL8A;ARL8B;RUFY3;RUFY4		new_to_goa		This PN subtype denotes the bridging machinery that links HOPS/BORC-like late-endolysosomal transport systems to autophagosome positioning on microtubules. The best current GO target is autophagosome localization.	This preserves the transport/positioning semantics of the leaf without collapsing it into broader axonal or lysosomal transport terms.	proteostasis-workbook-2024; proteostasis-ms2
RUFY3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
RUFY3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
RUFY3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ok_for_propagation_to_go	GO:0061906	autophagosome localization	ARL8A;ARL8B;RUFY3;RUFY4		new_to_goa		This PN subtype denotes the bridging machinery that links HOPS/BORC-like late-endolysosomal transport systems to autophagosome positioning on microtubules. The best current GO target is autophagosome localization.	This preserves the transport/positioning semantics of the leaf without collapsing it into broader axonal or lysosomal transport terms.	proteostasis-workbook-2024; proteostasis-ms2
RUFY4		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
RUFY4		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
RUFY4		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	HOPS-BORC complex bridging	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ok_for_propagation_to_go	GO:0061906	autophagosome localization	ARL8A;ARL8B;RUFY3;RUFY4		new_to_goa		This PN subtype denotes the bridging machinery that links HOPS/BORC-like late-endolysosomal transport systems to autophagosome positioning on microtubules. The best current GO target is autophagosome localization.	This preserves the transport/positioning semantics of the leaf without collapsing it into broader axonal or lysosomal transport terms.	proteostasis-workbook-2024; proteostasis-ms2
MAPK8IP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Miscellaneous function - movement of autophagosomes along microtubules	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
MAPK8IP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Miscellaneous function - movement of autophagosomes along microtubules	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
FYCO1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Miscellaneous function - movement of autophagosomes along microtubules	autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
FYCO1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along microtubules	Miscellaneous function - movement of autophagosomes along microtubules	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
MYO6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
MYO6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MYO6;TAX1BP1;TOM1;CALCOCO2		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
TAX1BP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
TAX1BP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MYO6;TAX1BP1;TOM1;CALCOCO2		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
TOM1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
TOM1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MYO6;TAX1BP1;TOM1;CALCOCO2		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
CALCOCO2		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CALCOCO2		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Movement of autophagosomes along actin		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MYO6;TAX1BP1;TOM1;CALCOCO2		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
HTT		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Retrograde transport along axons		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
HTT		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Retrograde transport along axons		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	ok_for_propagation_to_go	GO:0061906	autophagosome localization	HTT;HAP1		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
HAP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Retrograde transport along axons		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
HAP1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Retrograde transport along axons		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	ok_for_propagation_to_go	GO:0061906	autophagosome localization	HTT;HAP1		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
OSBPL1A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Recruitment of autophagosome to vicinity of ER		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
OSBPL1A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Recruitment of autophagosome to vicinity of ER		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	ok_for_propagation_to_go	GO:0061906	autophagosome localization	OSBPL1A;VAPA		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
VAPA		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Recruitment of autophagosome to vicinity of ER		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome	ok_for_propagation_to_go	GO:0061906	autophagosome localization	MAP1LC3B;RILP;ARL8A;ARL8B;RUFY3		new_to_goa		This group is explicitly about positioning/autophagosome localization in late autophagy. Autophagosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
VAPA		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the autophagosome	Recruitment of autophagosome to vicinity of ER		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	ok_for_propagation_to_go	GO:0061906	autophagosome localization	OSBPL1A;VAPA		new_to_goa		This leaf describes a mechanism for positioning autophagosomes. The safe shared GO target is autophagosome localization, not the downstream fusion process.		proteostasis-workbook-2026; proteostasis-ms2
ATG4A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Regulation of autophagosome membrane composition	ATG8 homolog de-lipidation	Releases ATG8 homologs from maturing autophagosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	ok_for_propagation_to_go	GO:0051697	protein delipidation	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0051697 protein delipidation	This PN subtype specifically denotes removal of lipidated ATG8-family proteins from the maturing autophagosome membrane. The best current GO process target is protein delipidation.	This is a cleaner mechanistic mapping than the broader late-fusion process context because the PN leaf is explicitly about the de-lipidation reaction itself.	proteostasis-workbook-2024; proteostasis-ms2
ATG4B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Regulation of autophagosome membrane composition	ATG8 homolog de-lipidation	Releases ATG8 homologs from maturing autophagosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	ok_for_propagation_to_go	GO:0051697	protein delipidation	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0051697 protein delipidation	This PN subtype specifically denotes removal of lipidated ATG8-family proteins from the maturing autophagosome membrane. The best current GO process target is protein delipidation.	This is a cleaner mechanistic mapping than the broader late-fusion process context because the PN leaf is explicitly about the de-lipidation reaction itself.	proteostasis-workbook-2024; proteostasis-ms2
ATG4C		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Regulation of autophagosome membrane composition	ATG8 homolog de-lipidation	Releases ATG8 homologs from maturing autophagosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	ok_for_propagation_to_go	GO:0051697	protein delipidation	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0051697 protein delipidation	This PN subtype specifically denotes removal of lipidated ATG8-family proteins from the maturing autophagosome membrane. The best current GO process target is protein delipidation.	This is a cleaner mechanistic mapping than the broader late-fusion process context because the PN leaf is explicitly about the de-lipidation reaction itself.	proteostasis-workbook-2024; proteostasis-ms2
ATG4D		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Regulation of autophagosome membrane composition	ATG8 homolog de-lipidation	Releases ATG8 homologs from maturing autophagosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Regulation of autophagosome membrane composition|ATG8 homolog de-lipidation|Releases ATG8 homologs from maturing autophagosome	ok_for_propagation_to_go	GO:0051697	protein delipidation	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0051697 protein delipidation	This PN subtype specifically denotes removal of lipidated ATG8-family proteins from the maturing autophagosome membrane. The best current GO process target is protein delipidation.	This is a cleaner mechanistic mapping than the broader late-fusion process context because the PN leaf is explicitly about the de-lipidation reaction itself.	proteostasis-workbook-2024; proteostasis-ms2
PIK3C3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		already_in_goa_exact	GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II	This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
PIK3R4		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		already_in_goa_exact	GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II	This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
BECN1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		already_in_goa_exact	GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II	This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
UVRAG		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		more_specific_than_existing_goa	GO:0032991 protein-containing complex	This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
SH3GLB1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		more_specific_than_existing_goa	GO:0016020 membrane;GO:0032991 protein-containing complex	This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
RUBCN		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		new_to_goa		This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
RUBCNL		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Class 3 PI3K complex 2, direct	Class 3 PI3K complex 2 component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	ok_for_propagation_to_go	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PIK3C3;PIK3R4;BECN1;UVRAG;SH3GLB1		new_to_goa		This PN type denotes component membership in the direct class III PI3K complex 2 module used during autophagosome maturation and lysosome fusion. The corresponding GO complex term is the right propagation target.		proteostasis-workbook-2024; proteostasis-ms2
VTI1B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-endosome docking|Lysosome-endosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-endosome docking	Lysosome-endosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-endosome docking|Lysosome-endosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	VTI1B;VAMP3;STX6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is a SNARE machinery bucket in the autophagosome-endosome docking context. The shared gene-level assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VAMP3		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-endosome docking|Lysosome-endosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-endosome docking	Lysosome-endosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-endosome docking|Lysosome-endosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	VTI1B;VAMP3;STX6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is a SNARE machinery bucket in the autophagosome-endosome docking context. The shared gene-level assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
STX6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-endosome docking|Lysosome-endosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-endosome docking	Lysosome-endosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-endosome docking|Lysosome-endosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	VTI1B;VAMP3;STX6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is a SNARE machinery bucket in the autophagosome-endosome docking context. The shared gene-level assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
RAB8B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Lysosome-autophagosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	RAB8B;STX17;STX7;SNAP29;YKT6		new_to_goa		This leaf is restricted to SNARE machinery for lysosome-autophagosome docking. The shared GO assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
STX17		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Lysosome-autophagosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	RAB8B;STX17;STX7;SNAP29;YKT6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is restricted to SNARE machinery for lysosome-autophagosome docking. The shared GO assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
STX7		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Lysosome-autophagosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	RAB8B;STX17;STX7;SNAP29;YKT6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is restricted to SNARE machinery for lysosome-autophagosome docking. The shared GO assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
SNAP29		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Lysosome-autophagosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	RAB8B;STX17;STX7;SNAP29;YKT6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is restricted to SNARE machinery for lysosome-autophagosome docking. The shared GO assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
YKT6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Lysosome-autophagosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	RAB8B;STX17;STX7;SNAP29;YKT6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is restricted to SNARE machinery for lysosome-autophagosome docking. The shared GO assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VAMP8		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Lysosome-autophagosome SNARE complex		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	ok_for_propagation_to_go	GO:0031201	SNARE complex	RAB8B;STX17;STX7;SNAP29;YKT6		already_in_goa_exact	GO:0031201 SNARE complex	This leaf is restricted to SNARE machinery for lysosome-autophagosome docking. The shared GO assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
BLOC1S1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
BLOC1S2		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
SNAPIN		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
KXD1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
BORCS5		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
BORCS6		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
BORCS7		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
BORCS8		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	BORC complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|BORC complex component	ok_for_propagation_to_go	GO:0099078	BORC complex	BLOC1S1;BLOC1S2;SNAPIN;KXD1;BORCS5		already_in_goa_exact	GO:0099078 BORC complex	This leaf is restricted to BORC complex components, so the BORC complex cellular-component term is the direct propagation target.		proteostasis-workbook-2026; proteostasis-ms2
VPS11		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	HOPS complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This PN type groups genes that are components of the HOPS tethering complex in the autophagosome-lysosome docking step. That supports propagation to the GO cellular-component term for HOPS complex.		proteostasis-workbook-2024; proteostasis-ms2
VPS16		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	HOPS complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This PN type groups genes that are components of the HOPS tethering complex in the autophagosome-lysosome docking step. That supports propagation to the GO cellular-component term for HOPS complex.		proteostasis-workbook-2024; proteostasis-ms2
VPS18		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	HOPS complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This PN type groups genes that are components of the HOPS tethering complex in the autophagosome-lysosome docking step. That supports propagation to the GO cellular-component term for HOPS complex.		proteostasis-workbook-2024; proteostasis-ms2
VPS33A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	HOPS complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This PN type groups genes that are components of the HOPS tethering complex in the autophagosome-lysosome docking step. That supports propagation to the GO cellular-component term for HOPS complex.		proteostasis-workbook-2024; proteostasis-ms2
VPS39		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	HOPS complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This PN type groups genes that are components of the HOPS tethering complex in the autophagosome-lysosome docking step. That supports propagation to the GO cellular-component term for HOPS complex.		proteostasis-workbook-2024; proteostasis-ms2
VPS41		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	HOPS complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This PN type groups genes that are components of the HOPS tethering complex in the autophagosome-lysosome docking step. That supports propagation to the GO cellular-component term for HOPS complex.		proteostasis-workbook-2024; proteostasis-ms2
MAP1LC3A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	MAP1LC3A;MAP1LC3B;MAP1LC3C;GABARAP;GABARAPL1		already_in_goa_exact	GO:0097352 autophagosome maturation	This PN leaf captures ATG8-family proteins in their specific role of recruiting HOPS machinery during late autophagosome handling. The best GO process target for that shared role is autophagosome maturation.	The same genes also participate earlier in autophagosome assembly, but this leaf is explicitly restricted to the late maturation and docking step.	proteostasis-workbook-2024; proteostasis-ms2
MAP1LC3B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	MAP1LC3A;MAP1LC3B;MAP1LC3C;GABARAP;GABARAPL1		already_in_goa_exact	GO:0097352 autophagosome maturation	This PN leaf captures ATG8-family proteins in their specific role of recruiting HOPS machinery during late autophagosome handling. The best GO process target for that shared role is autophagosome maturation.	The same genes also participate earlier in autophagosome assembly, but this leaf is explicitly restricted to the late maturation and docking step.	proteostasis-workbook-2024; proteostasis-ms2
MAP1LC3C		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	MAP1LC3A;MAP1LC3B;MAP1LC3C;GABARAP;GABARAPL1		already_in_goa_exact	GO:0097352 autophagosome maturation	This PN leaf captures ATG8-family proteins in their specific role of recruiting HOPS machinery during late autophagosome handling. The best GO process target for that shared role is autophagosome maturation.	The same genes also participate earlier in autophagosome assembly, but this leaf is explicitly restricted to the late maturation and docking step.	proteostasis-workbook-2024; proteostasis-ms2
GABARAP		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	MAP1LC3A;MAP1LC3B;MAP1LC3C;GABARAP;GABARAPL1		already_in_goa_exact	GO:0097352 autophagosome maturation	This PN leaf captures ATG8-family proteins in their specific role of recruiting HOPS machinery during late autophagosome handling. The best GO process target for that shared role is autophagosome maturation.	The same genes also participate earlier in autophagosome assembly, but this leaf is explicitly restricted to the late maturation and docking step.	proteostasis-workbook-2024; proteostasis-ms2
GABARAPL1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	MAP1LC3A;MAP1LC3B;MAP1LC3C;GABARAP;GABARAPL1		already_in_goa_exact	GO:0097352 autophagosome maturation	This PN leaf captures ATG8-family proteins in their specific role of recruiting HOPS machinery during late autophagosome handling. The best GO process target for that shared role is autophagosome maturation.	The same genes also participate earlier in autophagosome assembly, but this leaf is explicitly restricted to the late maturation and docking step.	proteostasis-workbook-2024; proteostasis-ms2
GABARAPL2		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	ATG8 homolog	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|ATG8 homolog	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	MAP1LC3A;MAP1LC3B;MAP1LC3C;GABARAP;GABARAPL1		already_in_goa_exact	GO:0097352 autophagosome maturation	This PN leaf captures ATG8-family proteins in their specific role of recruiting HOPS machinery during late autophagosome handling. The best GO process target for that shared role is autophagosome maturation.	The same genes also participate earlier in autophagosome assembly, but this leaf is explicitly restricted to the late maturation and docking step.	proteostasis-workbook-2024; proteostasis-ms2
PLEKHM1		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges ATG8 and HOPS complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	Bridges ATG8 and HOPS complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges ATG8 and HOPS complex	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	PLEKHM1		new_to_goa		This PN leaf denotes a direct bridging factor that links ATG8 proteins to HOPS recruitment on late autophagic membranes. That is a narrow mechanistic role within autophagosome maturation.	The source leaf is single-gene today, but the mechanism is specific and maps cleanly to the late maturation step.	proteostasis-workbook-2024; proteostasis-ms2
RAB2A		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges STX17, RUBCNL and HOPS complex	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Autophagosome-lysosome docking	Recruitment of HOPS complex to autophagosome	Bridges STX17, RUBCNL and HOPS complex	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges STX17, RUBCNL and HOPS complex	ok_for_propagation_to_go	GO:0097352	autophagosome maturation	RAB2A		more_specific_than_existing_goa	GO:0016236 macroautophagy	This PN leaf captures a direct bridging factor that couples autophagosome SNARE and HOPS-recruitment machinery during the late fusion-ready stage. The corresponding GO process is autophagosome maturation.		proteostasis-workbook-2024; proteostasis-ms2
KIF5B		Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the lysosome	Autophagy-Lysosome Pathway	Autophagosome closure maturation and lysosome fusion	Localization of the lysosome			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the lysosome	ok_for_propagation_to_go	GO:0032418	lysosome localization	KIF5B		already_in_goa_exact	GO:0032418 lysosome localization	This group is explicitly about lysosome positioning in late autophagy. Lysosome localization is the correct propagation target rather than autophagosome-lysosome fusion.		proteostasis-workbook-2026; proteostasis-ms2
CTSA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004180 carboxypeptidase activity;GO:0004185 serine-type carboxypeptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSB		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSC		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004197 cysteine-type endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0008239 dipeptidyl-peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSD		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSF		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSG		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSH		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSK		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSL		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSO		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSS		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSV		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004197 cysteine-type endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSW		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
CTSZ		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004180 carboxypeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity;GO:0016807 cysteine-type carboxypeptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
PRTN3		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protease		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protease	ok_for_propagation_to_go	GO:0008233	peptidase activity	CTSA;CTSB;CTSC;CTSD;CTSF		entailed_by_goa_closure	GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity	This leaf groups lysosomal proteases, including cathepsin-family members. GO cathepsin-specific terms are obsolete in the local cache, so peptidase activity is the safe shared target.		proteostasis-workbook-2026; proteostasis-ms2
DPP4		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal peptidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	ok_for_propagation_to_go	GO:0008233	peptidase activity	DPP4;DPP7;GGH;LGMN;TPP1		entailed_by_goa_closure	GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity;GO:0008239 dipeptidyl-peptidase activity;GO:0008240 tripeptidyl-peptidase activity	This leaf groups lysosomal peptidases. The broad peptidase activity term is the safest shared molecular-function target across the members.		proteostasis-workbook-2026; proteostasis-ms2
DPP7		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal peptidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	ok_for_propagation_to_go	GO:0008233	peptidase activity	DPP4;DPP7;GGH;LGMN;TPP1		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal peptidases. The broad peptidase activity term is the safest shared molecular-function target across the members.		proteostasis-workbook-2026; proteostasis-ms2
GGH		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal peptidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	ok_for_propagation_to_go	GO:0008233	peptidase activity	DPP4;DPP7;GGH;LGMN;TPP1		entailed_by_goa_closure	GO:0008238 exopeptidase activity;GO:0008242 omega peptidase activity;GO:0034722 gamma-glutamyl-peptidase activity	This leaf groups lysosomal peptidases. The broad peptidase activity term is the safest shared molecular-function target across the members.		proteostasis-workbook-2026; proteostasis-ms2
LGMN		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal peptidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	ok_for_propagation_to_go	GO:0008233	peptidase activity	DPP4;DPP7;GGH;LGMN;TPP1		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal peptidases. The broad peptidase activity term is the safest shared molecular-function target across the members.		proteostasis-workbook-2026; proteostasis-ms2
TPP1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal peptidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal peptidase	ok_for_propagation_to_go	GO:0008233	peptidase activity	DPP4;DPP7;GGH;LGMN;TPP1		already_in_goa_exact	GO:0008233 peptidase activity	This leaf groups lysosomal peptidases. The broad peptidase activity term is the safest shared molecular-function target across the members.		proteostasis-workbook-2026; proteostasis-ms2
PPT1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal de-palmitoylation	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal de-palmitoylation		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal de-palmitoylation	ok_for_propagation_to_go	GO:0098599	palmitoyl hydrolase activity	PPT1;PPT2		already_in_goa_exact	GO:0098599 palmitoyl hydrolase activity	This leaf groups PPT-family lysosomal depalmitoylating enzymes; palmitoyl hydrolase activity captures the shared molecular function.		proteostasis-workbook-2026; proteostasis-ms2
PPT2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal de-palmitoylation	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal de-palmitoylation		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal de-palmitoylation	ok_for_propagation_to_go	GO:0098599	palmitoyl hydrolase activity	PPT1;PPT2		already_in_goa_exact	GO:0098599 palmitoyl hydrolase activity	This leaf groups PPT-family lysosomal depalmitoylating enzymes; palmitoyl hydrolase activity captures the shared molecular function.		proteostasis-workbook-2026; proteostasis-ms2
PCYOX1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal de-prenylation	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal de-prenylation		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal de-prenylation	ok_for_propagation_to_go	GO:0001735	prenylcysteine oxidase activity	PCYOX1		already_in_goa_exact	GO:0001735 prenylcysteine oxidase activity	This leaf corresponds to PCYOX1-like lysosomal prenylcysteine catabolism; prenylcysteine oxidase activity is the direct GO target.		proteostasis-workbook-2026; proteostasis-ms2
PON2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal arylesterase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal arylesterase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal arylesterase	ok_for_propagation_to_go	GO:0004064	arylesterase activity	PON2		already_in_goa_exact	GO:0004064 arylesterase activity	This leaf corresponds to a lysosomal arylesterase bucket; arylesterase activity is the direct molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
TXNDC5		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protein disulfide isomerase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal protein disulfide isomerase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal protein disulfide isomerase	ok_for_propagation_to_go	GO:0003756	protein disulfide isomerase activity	TXNDC5		already_in_goa_exact	GO:0003756 protein disulfide isomerase activity	This leaf is currently a lysosomal protein disulfide isomerase bucket; protein disulfide isomerase activity is the direct GO molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
IFI30		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal thiol reductase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal protein catabolism	Lysosomal thiol reductase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal thiol reductase	ok_for_propagation_to_go	GO:0015035	protein-disulfide reductase activity	IFI30		more_specific_than_existing_goa	GO:0016667 oxidoreductase activity, acting on a sulfur group of donors	This leaf corresponds to IFI30/GILT-like lysosomal thiol reductase activity; protein-disulfide reductase activity is the closest shared GO target.		proteostasis-workbook-2026; proteostasis-ms2
AGA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal protein deglycosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal protein deglycosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal protein deglycosidase	ok_for_propagation_to_go	GO:0003948	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	AGA		already_in_goa_exact	GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	This leaf corresponds to AGA-like lysosomal glycoasparagine deglycosylation; the GO glycoasparaginase activity term is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
GAA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal glucosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal glucosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal glucosidase	ok_for_propagation_to_go	GO:0090599	alpha-glucosidase activity	GAA		already_in_goa_exact	GO:0090599 alpha-glucosidase activity	This leaf is currently the lysosomal GAA glucosidase bucket, so alpha-glucosidase activity is the appropriate molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
GLA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal galactosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal galactosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal galactosidase	ok_for_propagation_to_go	GO:0015925	galactosidase activity	GLA;GLB1		entailed_by_goa_closure	GO:0004557 alpha-galactosidase activity	The leaf groups lysosomal galactosidases; galactosidase activity captures the shared molecular function.		proteostasis-workbook-2026; proteostasis-ms2
GLB1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal galactosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal galactosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal galactosidase	ok_for_propagation_to_go	GO:0015925	galactosidase activity	GLA;GLB1		entailed_by_goa_closure	GO:0004565 beta-galactosidase activity	The leaf groups lysosomal galactosidases; galactosidase activity captures the shared molecular function.		proteostasis-workbook-2026; proteostasis-ms2
MAN2B1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal mannosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal mannosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal mannosidase	ok_for_propagation_to_go	GO:0015923	mannosidase activity	MAN2B1;MAN2B2;MANBA		entailed_by_goa_closure	GO:0004559 alpha-mannosidase activity	The leaf groups lysosomal mannosidases; the shared GO target is mannosidase activity.		proteostasis-workbook-2026; proteostasis-ms2
MAN2B2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal mannosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal mannosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal mannosidase	ok_for_propagation_to_go	GO:0015923	mannosidase activity	MAN2B1;MAN2B2;MANBA		already_in_goa_exact	GO:0015923 mannosidase activity	The leaf groups lysosomal mannosidases; the shared GO target is mannosidase activity.		proteostasis-workbook-2026; proteostasis-ms2
MANBA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal mannosidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal mannosidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal mannosidase	ok_for_propagation_to_go	GO:0015923	mannosidase activity	MAN2B1;MAN2B2;MANBA		entailed_by_goa_closure	GO:0004567 beta-mannosidase activity	The leaf groups lysosomal mannosidases; the shared GO target is mannosidase activity.		proteostasis-workbook-2026; proteostasis-ms2
CHIT1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal chitobiase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal chitobiase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal chitobiase	ok_for_propagation_to_go	GO:0016798	hydrolase activity, acting on glycosyl bonds	CHIT1;CTBS		entailed_by_goa_closure	GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004568 chitinase activity;GO:0008843 endochitinase activity	This mixed CHIT1/CTBS bucket lacks a clean shared chitobiase GO activity in the local cache. The shared safe target is glycosyl-bond hydrolase activity.		proteostasis-workbook-2026; proteostasis-ms2
CTBS		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal chitobiase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal chitobiase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal chitobiase	ok_for_propagation_to_go	GO:0016798	hydrolase activity, acting on glycosyl bonds	CHIT1;CTBS		already_in_goa_exact	GO:0016798 hydrolase activity, acting on glycosyl bonds	This mixed CHIT1/CTBS bucket lacks a clean shared chitobiase GO activity in the local cache. The shared safe target is glycosyl-bond hydrolase activity.		proteostasis-workbook-2026; proteostasis-ms2
FUCA1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal fusocidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal fusocidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal fusocidase	ok_for_propagation_to_go	GO:0015928	fucosidase activity	FUCA1;FUCA2		entailed_by_goa_closure	GO:0004560 alpha-L-fucosidase activity	The leaf groups lysosomal fucosidase enzymes; fucosidase activity is the shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
FUCA2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal fusocidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal fusocidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal fusocidase	ok_for_propagation_to_go	GO:0015928	fucosidase activity	FUCA1;FUCA2		entailed_by_goa_closure	GO:0004560 alpha-L-fucosidase activity	The leaf groups lysosomal fucosidase enzymes; fucosidase activity is the shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
HYAL1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal hyaluronidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal hyaluronidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal hyaluronidase	ok_for_propagation_to_go	GO:0004415	hyalurononglucosaminidase activity	HYAL1;HYAL2;HYAL3		already_in_goa_exact	GO:0004415 hyalurononglucosaminidase activity	The leaf groups lysosomal hyaluronidase enzymes; hyalurononglucosaminidase activity is the matching GO molecular function.		proteostasis-workbook-2026; proteostasis-ms2
HYAL2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal hyaluronidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal hyaluronidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal hyaluronidase	ok_for_propagation_to_go	GO:0004415	hyalurononglucosaminidase activity	HYAL1;HYAL2;HYAL3		already_in_goa_exact	GO:0004415 hyalurononglucosaminidase activity	The leaf groups lysosomal hyaluronidase enzymes; hyalurononglucosaminidase activity is the matching GO molecular function.		proteostasis-workbook-2026; proteostasis-ms2
HYAL3		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal hyaluronidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal hyaluronidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal hyaluronidase	ok_for_propagation_to_go	GO:0004415	hyalurononglucosaminidase activity	HYAL1;HYAL2;HYAL3		already_in_goa_exact	GO:0004415 hyalurononglucosaminidase activity	The leaf groups lysosomal hyaluronidase enzymes; hyalurononglucosaminidase activity is the matching GO molecular function.		proteostasis-workbook-2026; proteostasis-ms2
GUSB		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal glucuronidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal glucuronidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal glucuronidase	ok_for_propagation_to_go	GO:0046574	glucuronidase activity	GUSB		entailed_by_goa_closure	GO:0004566 beta-glucuronidase activity	This leaf is a lysosomal glucuronidase enzyme bucket; the GO glucuronidase activity term is the matching molecular function.		proteostasis-workbook-2026; proteostasis-ms2
IDUA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal iduronidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal iduronidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal iduronidase	ok_for_propagation_to_go	GO:0003940	L-iduronidase activity	IDUA		already_in_goa_exact	GO:0003940 L-iduronidase activity	This leaf is the lysosomal IDUA iduronidase bucket; L-iduronidase activity is the direct GO molecular-function match.		proteostasis-workbook-2026; proteostasis-ms2
NEU1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal sialidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal sialidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal sialidase	ok_for_propagation_to_go	GO:0016997	alpha-sialidase activity	NEU1;NEU4		entailed_by_goa_closure	GO:0004308 exo-alpha-sialidase activity	The leaf groups lysosomal sialidases; alpha-sialidase activity is the matching GO molecular function.		proteostasis-workbook-2026; proteostasis-ms2
NEU4		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal sialidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal sialidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal sialidase	ok_for_propagation_to_go	GO:0016997	alpha-sialidase activity	NEU1;NEU4		entailed_by_goa_closure	GO:0004308 exo-alpha-sialidase activity	The leaf groups lysosomal sialidases; alpha-sialidase activity is the matching GO molecular function.		proteostasis-workbook-2026; proteostasis-ms2
SIAE		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal sialic acid deacetylase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal sialic acid deacetylase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal sialic acid deacetylase	ok_for_propagation_to_go	GO:0001681	sialate O-acetylesterase activity	SIAE		already_in_goa_exact	GO:0001681 sialate O-acetylesterase activity	This leaf corresponds to SIAE-like sialate O-acetylesterase activity.		proteostasis-workbook-2026; proteostasis-ms2
PYGB		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal phosphorylase for glycogen catabolism	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal phosphorylase for glycogen catabolism		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal phosphorylase for glycogen catabolism	ok_for_propagation_to_go	GO:0008184	glycogen phosphorylase activity	PYGB		already_in_goa_exact	GO:0008184 glycogen phosphorylase activity	This leaf is currently the PYGB glycogen-phosphorylase bucket; glycogen phosphorylase activity is the direct molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
HPSE		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparinase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal heparinase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparinase	ok_for_propagation_to_go	GO:0016798	hydrolase activity, acting on glycosyl bonds	HPSE;NAGLU		already_in_goa_exact	GO:0016798 hydrolase activity, acting on glycosyl bonds	This PN leaf mixes heparanase and alpha-N-acetylglucosaminidase-like carbohydrate hydrolases. A broad glycosyl-bond hydrolase activity is safer than forcing one exact substrate-specific term.		proteostasis-workbook-2026; proteostasis-ms2
NAGLU		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparinase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal heparinase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparinase	ok_for_propagation_to_go	GO:0016798	hydrolase activity, acting on glycosyl bonds	HPSE;NAGLU		entailed_by_goa_closure	GO:0004561 alpha-N-acetylglucosaminidase activity	This PN leaf mixes heparanase and alpha-N-acetylglucosaminidase-like carbohydrate hydrolases. A broad glycosyl-bond hydrolase activity is safer than forcing one exact substrate-specific term.		proteostasis-workbook-2026; proteostasis-ms2
HGSNAT		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparin acetyltransferase to prepare for heparin degradation	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal heparin acetyltransferase to prepare for heparin degradation		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparin acetyltransferase to prepare for heparin degradation	ok_for_propagation_to_go	GO:0015019	heparan-alpha-glucosaminide N-acetyltransferase activity	HGSNAT		already_in_goa_exact	GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity	This leaf corresponds to HGSNAT-like heparan-alpha-glucosaminide N-acetyltransferase activity in lysosomal heparan-sulfate degradation.		proteostasis-workbook-2026; proteostasis-ms2
SGSH		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparin sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal carbohydrate catabolism	Lysosomal heparin sulfatase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal carbohydrate catabolism|Lysosomal heparin sulfatase	ok_for_propagation_to_go	GO:0016250	N-sulfoglucosamine sulfohydrolase activity	SGSH		already_in_goa_exact	GO:0016250 N-sulfoglucosamine sulfohydrolase activity	This leaf corresponds to SGSH-like N-sulfoglucosamine sulfohydrolase activity in heparan-sulfate degradation.		proteostasis-workbook-2026; proteostasis-ms2
ABHD6		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal lipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal lipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal lipase	ok_for_propagation_to_go	GO:0016298	lipase activity	ABHD6;DAGLB;LIPA		entailed_by_goa_closure	GO:0004620 glycerophospholipase activity;GO:0047372 monoacylglycerol lipase activity	This leaf groups lysosomal lipid hydrolases; lipase activity is the conservative shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
DAGLB		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal lipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal lipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal lipase	ok_for_propagation_to_go	GO:0016298	lipase activity	ABHD6;DAGLB;LIPA		already_in_goa_exact	GO:0016298 lipase activity	This leaf groups lysosomal lipid hydrolases; lipase activity is the conservative shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
LIPA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal lipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal lipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal lipase	ok_for_propagation_to_go	GO:0016298	lipase activity	ABHD6;DAGLB;LIPA		already_in_goa_exact	GO:0016298 lipase activity	This leaf groups lysosomal lipid hydrolases; lipase activity is the conservative shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
PLA2G10		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004620 glycerophospholipase activity;GO:0004623 A2-type glycerophospholipase activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLA2G15		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004622 phosphatidylcholine lysophospholipase A1 activity;GO:0004623 A2-type glycerophospholipase activity;GO:0008970 glycerophospholipid phospholipase A1 activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLA2G4E		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004620 glycerophospholipase activity;GO:0004623 A2-type glycerophospholipase activity;GO:0008970 glycerophospholipid phospholipase A1 activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLA2G5		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004623 A2-type glycerophospholipase activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLBD1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		new_to_goa		This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLBD2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004620 glycerophospholipase activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLD1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004630 D-type glycerophospholipase activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PLD3		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		more_specific_than_existing_goa	GO:0003824 catalytic activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
PRDX6		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004623 A2-type glycerophospholipase activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
GPLD1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal phospholipase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	ok_for_propagation_to_go	GO:0120569	phospholipase activity	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		entailed_by_goa_closure	GO:0004621 GPI anchor phospholipase D activity;GO:0004630 D-type glycerophospholipase activity	This leaf groups lysosomal phospholipid hydrolases. The broad phospholipase activity term is safer than a subtype-specific phospholipase class for all members.		proteostasis-workbook-2026; proteostasis-ms2
NAAA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal fatty acid amidase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal fatty acid amidase		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal fatty acid amidase	ok_for_propagation_to_go	GO:0017064	fatty acid amide hydrolase activity	NAAA		already_in_goa_exact	GO:0017064 fatty acid amide hydrolase activity	This leaf corresponds to NAAA-like lysosomal fatty acid amide hydrolysis; fatty acid amide hydrolase activity is the shared molecular function.		proteostasis-workbook-2026; proteostasis-ms2
PSAP		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|General activator of glycosphingolipid degradation	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal sphingomyelin/ceramide metabolism	General activator of glycosphingolipid degradation	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|General activator of glycosphingolipid degradation	ok_for_propagation_to_go	GO:0030290	sphingolipid activator protein activity	PSAP		new_to_goa		This leaf corresponds to saposin/prosaposin-like activation of lysosomal glycosphingolipid degradation; sphingolipid activator protein activity is the shared GO target.		proteostasis-workbook-2026; proteostasis-ms2
NAGA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|Lysosomal glycosyl deacetylase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal sphingomyelin/ceramide metabolism	Lysosomal glycosyl deacetylase	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|Lysosomal glycosyl deacetylase	ok_for_propagation_to_go	GO:0008456	alpha-N-acetylgalactosaminidase activity	NAGA		already_in_goa_exact	GO:0008456 alpha-N-acetylgalactosaminidase activity	This leaf is currently the NAGA lysosomal alpha-N-acetylgalactosaminidase bucket; that GO molecular function is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
SMPD1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|Converts sphingomyelin to ceramide	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal sphingomyelin/ceramide metabolism	Converts sphingomyelin to ceramide	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|Converts sphingomyelin to ceramide	ok_for_propagation_to_go	GO:0061750	acid sphingomyelin phosphodiesterase activity	SMPD1		already_in_goa_exact	GO:0061750 acid sphingomyelin phosphodiesterase activity	This leaf corresponds to SMPD1-like lysosomal conversion of sphingomyelin to ceramide; acid sphingomyelin phosphodiesterase activity is the direct target.		proteostasis-workbook-2026; proteostasis-ms2
SPHK2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|Phosphorylates sphingomyelin	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal lipid catabolism	Lysosomal sphingomyelin/ceramide metabolism	Phosphorylates sphingomyelin	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|Phosphorylates sphingomyelin	ok_for_propagation_to_go	GO:0008481	sphingosine kinase activity	SPHK2		already_in_goa_exact	GO:0008481 sphingosine kinase activity	This leaf is currently SPHK2. The defensible shared GO activity for the member gene is sphingosine kinase activity.		proteostasis-workbook-2026; proteostasis-ms2
ACP2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal phosphatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	ok_for_propagation_to_go	GO:0016791	phosphatase activity	ACP2;ACP3;ACP4;ACP5		entailed_by_goa_closure	GO:0003993 acid phosphatase activity	This group contains lysosomal acid-phosphatase members, so phosphatase activity is the shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ACP3		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal phosphatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	ok_for_propagation_to_go	GO:0016791	phosphatase activity	ACP2;ACP3;ACP4;ACP5		already_in_goa_exact	GO:0016791 phosphatase activity	This group contains lysosomal acid-phosphatase members, so phosphatase activity is the shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ACP4		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal phosphatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	ok_for_propagation_to_go	GO:0016791	phosphatase activity	ACP2;ACP3;ACP4;ACP5		entailed_by_goa_closure	GO:0003993 acid phosphatase activity;GO:0004725 protein tyrosine phosphatase activity	This group contains lysosomal acid-phosphatase members, so phosphatase activity is the shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ACP5		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal phosphatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal phosphatase	ok_for_propagation_to_go	GO:0016791	phosphatase activity	ACP2;ACP3;ACP4;ACP5		entailed_by_goa_closure	GO:0003993 acid phosphatase activity	This group contains lysosomal acid-phosphatase members, so phosphatase activity is the shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ARSA		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		already_in_goa_exact	GO:0008484 sulfuric ester hydrolase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
ARSB		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		already_in_goa_exact	GO:0008484 sulfuric ester hydrolase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
ARSD		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		entailed_by_goa_closure	GO:0004065 arylsulfatase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
ARSG		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		entailed_by_goa_closure	GO:0004065 arylsulfatase activity;GO:0033889 N-sulfoglucosamine-3-sulfatase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
GALNS		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		already_in_goa_exact	GO:0008484 sulfuric ester hydrolase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
GNS		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		already_in_goa_exact	GO:0008484 sulfuric ester hydrolase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
IDS		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		already_in_goa_exact	GO:0008484 sulfuric ester hydrolase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
STS		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal sulfatase			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal sulfatase	ok_for_propagation_to_go	GO:0008484	sulfuric ester hydrolase activity	ARSA;ARSB;ARSD;ARSG;GALNS		already_in_goa_exact	GO:0008484 sulfuric ester hydrolase activity	This group contains multiple lysosomal sulfatases with different substrates. The broad sulfuric ester hydrolase activity term captures the shared chemistry without over-specifying one substrate.		proteostasis-workbook-2026; proteostasis-ms2
DNASE2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal nuclease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal nuclease			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal nuclease	ok_for_propagation_to_go	GO:0004518	nuclease activity	DNASE2;DNASE2B		entailed_by_goa_closure	GO:0004520 DNA endonuclease activity;GO:0004531 deoxyribonuclease II activity	This group is restricted to lysosomal DNASE2-family nucleases, so nuclease activity is a safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
DNASE2B		Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal nuclease	Autophagy-Lysosome Pathway	Lysosomal catabolism	Lysosomal nuclease			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal nuclease	ok_for_propagation_to_go	GO:0004518	nuclease activity	DNASE2;DNASE2B		entailed_by_goa_closure	GO:0004520 DNA endonuclease activity;GO:0004531 deoxyribonuclease II activity	This group is restricted to lysosomal DNASE2-family nucleases, so nuclease activity is a safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms2
ATP6V0A1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0A1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0A2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0007035 vacuolar acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0A2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
TCIRG1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
TCIRG1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0A4		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0006885 regulation of pH;GO:0007035 vacuolar acidification;GO:0051452 intracellular pH reduction	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0A4		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0B		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0B		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0C		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0C		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0D1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0007035 vacuolar acidification;GO:0042592 homeostatic process	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0D1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0D2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0007035 vacuolar acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0D2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0E1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0007035 vacuolar acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0E1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0E2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0007035 vacuolar acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V0E2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V0 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033179	proton-transporting V-type ATPase, V0 domain	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0033179 proton-transporting V-type ATPase, V0 domain	This PN subtype denotes the V0-sector component of the lysosomal V-type ATPase. The GO V0-domain component term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1A		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1A		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		already_in_goa_exact	GO:0033176 proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1B1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0006885 regulation of pH;GO:0007035 vacuolar acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1B1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1B2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		more_specific_than_existing_goa	GO:0007035 vacuolar acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1B2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1C1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1C1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		already_in_goa_exact	GO:0033176 proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1C2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1C2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180 proton-transporting V-type ATPase, V1 domain	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1D		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1D		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		already_in_goa_exact	GO:0033176 proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1E1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1E1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1E2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1E2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		new_to_goa		This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1F		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1F		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		already_in_goa_exact	GO:0033176 proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1G1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1G1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		already_in_goa_exact	GO:0033176 proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1G2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1G2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1G3		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1G3		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1H		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6V1H		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	V1 lysosomal v-ATPase proton pump component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ok_for_propagation_to_go	GO:0033176	proton-transporting V-type ATPase complex	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		entailed_by_goa_closure	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain	This PN subtype denotes the V1-sector component of the lysosomal V-ATPase. In the current GO cache, the broader V-type ATPase complex is the safest validated target for this component role.		proteostasis-workbook-2024; proteostasis-ms2
ATP6AP1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6AP1		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	ok_for_propagation_to_go	GO:0060590	ATPase regulator activity	ATP6AP1;ATP6AP2;LRRK2		new_to_goa		This PN subtype is a regulator of the lysosomal V-ATPase proton pump. ATPase regulator activity is the narrowest GO target that preserves the source mechanism without requiring a speculative complex-specific term.		proteostasis-workbook-2024; proteostasis-ms2
ATP6AP2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
ATP6AP2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	ok_for_propagation_to_go	GO:0060590	ATPase regulator activity	ATP6AP1;ATP6AP2;LRRK2		new_to_goa		This PN subtype is a regulator of the lysosomal V-ATPase proton pump. ATPase regulator activity is the narrowest GO target that preserves the source mechanism without requiring a speculative complex-specific term.		proteostasis-workbook-2024; proteostasis-ms2
LRRK2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
LRRK2		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Regulator of the lysosomal v-ATPase proton pump	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	ok_for_propagation_to_go	GO:0060590	ATPase regulator activity	ATP6AP1;ATP6AP2;LRRK2		new_to_goa		This PN subtype is a regulator of the lysosomal V-ATPase proton pump. ATPase regulator activity is the narrowest GO target that preserves the source mechanism without requiring a speculative complex-specific term.		proteostasis-workbook-2024; proteostasis-ms2
GRN		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Miscellaneous function - lysosomal acidification	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		already_in_goa_exact	GO:0007042 lysosomal lumen acidification	This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
TMEM106B		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Miscellaneous function - lysosomal acidification	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
TMEM175		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Miscellaneous function - lysosomal acidification	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
CLCN7		Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	Autophagy-Lysosome Pathway	Lysosomal catabolism	Regulation of lysosomal environment	Lysosomal acidification	Miscellaneous function - lysosomal acidification	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	ok_for_propagation_to_go	GO:0007042	lysosomal lumen acidification	ATP6V0A1;ATP6V0A2;TCIRG1;ATP6V0A4;ATP6V0B		new_to_goa		This PN group directly names the lysosomal acidification mechanism. Propagation to the GO lysosomal lumen acidification term is an exact mechanistic match.		proteostasis-workbook-2024; proteostasis-ms2
SPNS1		Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products	Autophagy-Lysosome Pathway	Autophagic lysosome reformation	Efflux of autophagy products			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products	ok_for_propagation_to_go	GO:0007041	lysosomal transport	SPNS1		new_to_goa		This PN leaf denotes export of degradation products from the autolysosome during late-stage autophagic lysosome reformation. The closest current GO process term is lysosomal transport, because the key shared semantics are transport across the lysosomal/autolysosomal membrane rather than a specific cargo chemistry.	For SPNS1, existing GOA already captures cargo-level biology such as lysophospholipid transport and phospholipid efflux, but those terms do not capture the autophagic-lysosome-reformation context highlighted by the PN curation and the underlying starvation-recovery literature. Propagating to lysosomal transport would therefore add new process-level context rather than a wholly new molecular capability. This is useful but still incomplete, because GO lacks a more explicit term for efflux of autolysosomal degradation products during lysosome reformation.	proteostasis-workbook-2024; proteostasis-ms2
TFEB		Autophagy-Lysosome Pathway|Autophagy gene expression|TFEB transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	TFEB transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|TFEB transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	TFEB		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
ATF4		Autophagy-Lysosome Pathway|Autophagy gene expression|ATF4 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	ATF4 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|ATF4 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	ATF4		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
NFKB1		Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	NFkB transcriptional program	Component of NFkB transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		entailed_by_goa_closure	GO:0035525 NF-kappaB p50/p65 complex	This leaf is restricted to NF-kappaB transcription-factor subunits. The matching GO cellular-component term is NF-kappaB complex.		proteostasis-workbook-2026; proteostasis-ms2
NFKB2		Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	NFkB transcriptional program	Component of NFkB transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		more_specific_than_existing_goa	GO:0005634 nucleus	This leaf is restricted to NF-kappaB transcription-factor subunits. The matching GO cellular-component term is NF-kappaB complex.		proteostasis-workbook-2026; proteostasis-ms2
REL		Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	NFkB transcriptional program	Component of NFkB transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		more_specific_than_existing_goa	GO:0005634 nucleus	This leaf is restricted to NF-kappaB transcription-factor subunits. The matching GO cellular-component term is NF-kappaB complex.		proteostasis-workbook-2026; proteostasis-ms2
RELA		Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	NFkB transcriptional program	Component of NFkB transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		already_in_goa_exact	GO:0071159 NF-kappaB complex	This leaf is restricted to NF-kappaB transcription-factor subunits. The matching GO cellular-component term is NF-kappaB complex.		proteostasis-workbook-2026; proteostasis-ms2
RELB		Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	NFkB transcriptional program	Component of NFkB transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor	ok_for_propagation_to_go	GO:0071159	NF-kappaB complex	NFKB1;NFKB2;REL;RELA;RELB		more_specific_than_existing_goa	GO:0005634 nucleus;GO:0032991 protein-containing complex	This leaf is restricted to NF-kappaB transcription-factor subunits. The matching GO cellular-component term is NF-kappaB complex.		proteostasis-workbook-2026; proteostasis-ms2
FOS		Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	AP-1 transcriptional program	Component of AP-1 transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	ok_for_propagation_to_go	GO:0035976	transcription factor AP-1 complex	FOS;FOSB;FOSL1;FOSL2;JUN		already_in_goa_exact	GO:0035976 transcription factor AP-1 complex	This leaf is a component bucket for FOS/JUN-family AP-1 members. The GO transcription factor AP-1 complex term captures the shared component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
FOSB		Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	AP-1 transcriptional program	Component of AP-1 transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	ok_for_propagation_to_go	GO:0035976	transcription factor AP-1 complex	FOS;FOSB;FOSL1;FOSL2;JUN		more_specific_than_existing_goa	GO:0005634 nucleus	This leaf is a component bucket for FOS/JUN-family AP-1 members. The GO transcription factor AP-1 complex term captures the shared component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
FOSL1		Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	AP-1 transcriptional program	Component of AP-1 transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	ok_for_propagation_to_go	GO:0035976	transcription factor AP-1 complex	FOS;FOSB;FOSL1;FOSL2;JUN		more_specific_than_existing_goa	GO:0005634 nucleus	This leaf is a component bucket for FOS/JUN-family AP-1 members. The GO transcription factor AP-1 complex term captures the shared component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
FOSL2		Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	AP-1 transcriptional program	Component of AP-1 transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	ok_for_propagation_to_go	GO:0035976	transcription factor AP-1 complex	FOS;FOSB;FOSL1;FOSL2;JUN		already_in_goa_exact	GO:0035976 transcription factor AP-1 complex	This leaf is a component bucket for FOS/JUN-family AP-1 members. The GO transcription factor AP-1 complex term captures the shared component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
JUN		Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	AP-1 transcriptional program	Component of AP-1 transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	ok_for_propagation_to_go	GO:0035976	transcription factor AP-1 complex	FOS;FOSB;FOSL1;FOSL2;JUN		already_in_goa_exact	GO:0035976 transcription factor AP-1 complex	This leaf is a component bucket for FOS/JUN-family AP-1 members. The GO transcription factor AP-1 complex term captures the shared component-level assertion.		proteostasis-workbook-2026; proteostasis-ms2
FOXO1		Autophagy-Lysosome Pathway|Autophagy gene expression|FOXO transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	FOXO transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|FOXO transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	FOXO1;FOXO3		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
FOXO3		Autophagy-Lysosome Pathway|Autophagy gene expression|FOXO transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	FOXO transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|FOXO transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	FOXO1;FOXO3		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
IRF8		Autophagy-Lysosome Pathway|Autophagy gene expression|IRF8 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	IRF8 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|IRF8 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	IRF8		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
NFE2L2		Autophagy-Lysosome Pathway|Autophagy gene expression|NFE2L2 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	NFE2L2 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|NFE2L2 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	NFE2L2		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
STAT3		Autophagy-Lysosome Pathway|Autophagy gene expression|STAT3 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	STAT3 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|STAT3 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	STAT3		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
STAT6		Autophagy-Lysosome Pathway|Autophagy gene expression|STAT6 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	STAT6 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|STAT6 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	STAT6		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
CEBPB		Autophagy-Lysosome Pathway|Autophagy gene expression|ATF6/CEBPB transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	ATF6/CEBPB transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|ATF6/CEBPB transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	CEBPB;ATF6		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
ATF6		Autophagy-Lysosome Pathway|Autophagy gene expression|ATF6/CEBPB transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	ATF6/CEBPB transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|ATF6/CEBPB transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	CEBPB;ATF6		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
TCF7L2		Autophagy-Lysosome Pathway|Autophagy gene expression|TCF7L2 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	TCF7L2 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|TCF7L2 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	TCF7L2		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
HIF1A		Autophagy-Lysosome Pathway|Autophagy gene expression|HIF1A transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	HIF1A transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|HIF1A transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	HIF1A		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
TFE3		Autophagy-Lysosome Pathway|Autophagy gene expression|TFE3 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	TFE3 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|TFE3 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	TFE3		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
GATA1		Autophagy-Lysosome Pathway|Autophagy gene expression|GATA1 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	GATA1 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|GATA1 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	GATA1		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
GATA4		Autophagy-Lysosome Pathway|Autophagy gene expression|GATA4 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	GATA4 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|GATA4 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	GATA4		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
TP53		Autophagy-Lysosome Pathway|Autophagy gene expression|TP53 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	TP53 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|TP53 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	TP53		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
TP63		Autophagy-Lysosome Pathway|Autophagy gene expression|TP63 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	TP63 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|TP63 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	TP63		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
TP73		Autophagy-Lysosome Pathway|Autophagy gene expression|TP73 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	TP73 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|TP73 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	TP73		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
DDIT3		Autophagy-Lysosome Pathway|Autophagy gene expression|DDIT3 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	DDIT3 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|DDIT3 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	DDIT3		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
E2F1		Autophagy-Lysosome Pathway|Autophagy gene expression|E2F1 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	E2F1 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|E2F1 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	E2F1		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
SOX2		Autophagy-Lysosome Pathway|Autophagy gene expression|SOX2 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	SOX2 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|SOX2 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	SOX2		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
SREBF2		Autophagy-Lysosome Pathway|Autophagy gene expression|SREBF2 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	SREBF2 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|SREBF2 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	SREBF2		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
ATF5		Autophagy-Lysosome Pathway|Autophagy gene expression|ATF5 transcriptional program|Transcription factor	Autophagy-Lysosome Pathway	Autophagy gene expression	ATF5 transcriptional program	Transcription factor		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|ATF5 transcriptional program|Transcription factor	ok_for_propagation_to_go	GO:0003700	DNA-binding transcription factor activity	ATF5		already_in_goa_exact	GO:0003700 DNA-binding transcription factor activity	This leaf is explicitly restricted to transcription-factor members of an autophagy-linked expression program. The safe shared GO assertion is DNA-binding transcription factor activity, not regulation of autophagy itself.		proteostasis-workbook-2026; proteostasis-ms2
WWTR1		Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator|Cellular mechanics sensing	Autophagy-Lysosome Pathway	Autophagy gene expression	Transcriptional coactivator	Cellular mechanics sensing		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator	ok_for_propagation_to_go	GO:0003713	transcription coactivator activity	WWTR1;YAP1		already_in_goa_exact	GO:0003713 transcription coactivator activity	This PN group contains YAP/TAZ coactivator members assigned to autophagy-linked gene-expression control. The shared GO assertion is transcription coactivator activity.		proteostasis-workbook-2026; proteostasis-ms2
WWTR1		Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator|Cellular mechanics sensing	Autophagy-Lysosome Pathway	Autophagy gene expression	Transcriptional coactivator	Cellular mechanics sensing		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator|Cellular mechanics sensing	ok_for_propagation_to_go	GO:0003713	transcription coactivator activity	WWTR1;YAP1		already_in_goa_exact	GO:0003713 transcription coactivator activity	This leaf contains YAP/TAZ cellular-mechanics sensors whose shared gene-level role is transcription coactivator activity. The autophagy-program context should not be converted into regulation of autophagy for every member.		proteostasis-workbook-2026; proteostasis-ms2
YAP1		Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator|Cellular mechanics sensing	Autophagy-Lysosome Pathway	Autophagy gene expression	Transcriptional coactivator	Cellular mechanics sensing		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator	ok_for_propagation_to_go	GO:0003713	transcription coactivator activity	WWTR1;YAP1		already_in_goa_exact	GO:0003713 transcription coactivator activity	This PN group contains YAP/TAZ coactivator members assigned to autophagy-linked gene-expression control. The shared GO assertion is transcription coactivator activity.		proteostasis-workbook-2026; proteostasis-ms2
YAP1		Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator|Cellular mechanics sensing	Autophagy-Lysosome Pathway	Autophagy gene expression	Transcriptional coactivator	Cellular mechanics sensing		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Autophagy gene expression|Transcriptional coactivator|Cellular mechanics sensing	ok_for_propagation_to_go	GO:0003713	transcription coactivator activity	WWTR1;YAP1		already_in_goa_exact	GO:0003713 transcription coactivator activity	This leaf contains YAP/TAZ cellular-mechanics sensors whose shared gene-level role is transcription coactivator activity. The autophagy-program context should not be converted into regulation of autophagy for every member.		proteostasis-workbook-2026; proteostasis-ms2
PINK1		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Promotion of MDV formation by ubiquitination of substrates	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	Promotion of MDV formation by ubiquitination of substrates	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Promotion of MDV formation by ubiquitination of substrates	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	PINK1;PRKN		already_in_goa_exact	GO:0016567 protein ubiquitination	This leaf contains PINK1/PRKN-linked ubiquitination machinery for mitochondrion-derived vesicle formation. The safe GO target is protein ubiquitination rather than broad micromitophagy propagation.		proteostasis-workbook-2026; proteostasis-ms2
PRKN		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Promotion of MDV formation by ubiquitination of substrates	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	Promotion of MDV formation by ubiquitination of substrates	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Promotion of MDV formation by ubiquitination of substrates	ok_for_propagation_to_go	GO:0016567	protein ubiquitination	PINK1;PRKN		already_in_goa_exact	GO:0016567 protein ubiquitination	This leaf contains PINK1/PRKN-linked ubiquitination machinery for mitochondrion-derived vesicle formation. The safe GO target is protein ubiquitination rather than broad micromitophagy propagation.		proteostasis-workbook-2026; proteostasis-ms2
STX17		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Formation of SNARE complex to dock MDV to lysosome	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	Formation of SNARE complex to dock MDV to lysosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Formation of SNARE complex to dock MDV to lysosome	ok_for_propagation_to_go	GO:0031201	SNARE complex	STX17;SNAP29;VAMP7		already_in_goa_exact	GO:0031201 SNARE complex	This leaf contains SNARE machinery used for docking mitochondrion-derived vesicles to lysosomes. The shared gene-level assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
SNAP29		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Formation of SNARE complex to dock MDV to lysosome	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	Formation of SNARE complex to dock MDV to lysosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Formation of SNARE complex to dock MDV to lysosome	ok_for_propagation_to_go	GO:0031201	SNARE complex	STX17;SNAP29;VAMP7		already_in_goa_exact	GO:0031201 SNARE complex	This leaf contains SNARE machinery used for docking mitochondrion-derived vesicles to lysosomes. The shared gene-level assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VAMP7		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Formation of SNARE complex to dock MDV to lysosome	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	Formation of SNARE complex to dock MDV to lysosome	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|Formation of SNARE complex to dock MDV to lysosome	ok_for_propagation_to_go	GO:0031201	SNARE complex	STX17;SNAP29;VAMP7		already_in_goa_exact	GO:0031201 SNARE complex	This leaf contains SNARE machinery used for docking mitochondrion-derived vesicles to lysosomes. The shared gene-level assertion is SNARE complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS11		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	HOPS complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This leaf is restricted to HOPS complex components in a micromitophagy context. The shared GO assertion is HOPS complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS16		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	HOPS complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This leaf is restricted to HOPS complex components in a micromitophagy context. The shared GO assertion is HOPS complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS18		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	HOPS complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This leaf is restricted to HOPS complex components in a micromitophagy context. The shared GO assertion is HOPS complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS33A		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	HOPS complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This leaf is restricted to HOPS complex components in a micromitophagy context. The shared GO assertion is HOPS complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS39		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	HOPS complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This leaf is restricted to HOPS complex components in a micromitophagy context. The shared GO assertion is HOPS complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS41		Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	Autophagy-Lysosome Pathway	Microautophagy	Micromitophagy	PDH-positive MDV-mediated micromitophagy	HOPS complex component	autophagy_lysosome_pathway.yaml	subtype	Autophagy-Lysosome Pathway|Microautophagy|Micromitophagy|PDH-positive MDV-mediated micromitophagy|HOPS complex component	ok_for_propagation_to_go	GO:0030897	HOPS complex	VPS11;VPS16;VPS18;VPS33A;VPS39		already_in_goa_exact	GO:0030897 HOPS complex	This leaf is restricted to HOPS complex components in a micromitophagy context. The shared GO assertion is HOPS complex membership.		proteostasis-workbook-2026; proteostasis-ms2
HSPA8		Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	Autophagy-Lysosome Pathway	Microautophagy	Endosomal microautophagy			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	ok_for_propagation_to_go	GO:0061738	late endosomal microautophagy	HSPA8;DNAJB1;STIP1		new_to_goa		This PN group contains HSPA8/co-chaperone machinery for endosomal microautophagy. The matching GO process is late endosomal microautophagy.		proteostasis-workbook-2026; proteostasis-ms2
DNAJB1		Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	Autophagy-Lysosome Pathway	Microautophagy	Endosomal microautophagy			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	ok_for_propagation_to_go	GO:0061738	late endosomal microautophagy	HSPA8;DNAJB1;STIP1		new_to_goa		This PN group contains HSPA8/co-chaperone machinery for endosomal microautophagy. The matching GO process is late endosomal microautophagy.		proteostasis-workbook-2026; proteostasis-ms2
STIP1		Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	Autophagy-Lysosome Pathway	Microautophagy	Endosomal microautophagy			autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	ok_for_propagation_to_go	GO:0061738	late endosomal microautophagy	HSPA8;DNAJB1;STIP1		new_to_goa		This PN group contains HSPA8/co-chaperone machinery for endosomal microautophagy. The matching GO process is late endosomal microautophagy.		proteostasis-workbook-2026; proteostasis-ms2
CHMP1A		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP1B		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP2A		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP2B		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP3		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP4A		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP4B		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP4C		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP5		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP6		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
CHMP7		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		already_in_goa_exact	GO:0000815 ESCRT III complex	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS4A		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005768 endosome;GO:0010008 endosome membrane	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VPS4B		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005768 endosome;GO:0010008 endosome membrane	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
STX12		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		more_specific_than_existing_goa	GO:0010008 endosome membrane;GO:0012505 endomembrane system;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0031982 vesicle	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
VTI1A		Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway	Microautophagy	General microautophagy machinery	ESCRT-III complex component		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	ok_for_propagation_to_go	GO:0000815	ESCRT III complex	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3		more_specific_than_existing_goa	GO:0005737 cytoplasm;GO:0005768 endosome;GO:0012505 endomembrane system;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0098588 bounding membrane of organelle	This leaf is a component bucket for ESCRT-III machinery used in microautophagy contexts. The shared GO assertion is ESCRT III complex membership.		proteostasis-workbook-2026; proteostasis-ms2
HSPA8		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate delivery		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		already_in_goa_exact	GO:0061684 chaperone-mediated autophagy	This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
HSPA8		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate delivery		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	exact	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSPA8;DNAJB1;CLU		already_in_goa_exact	GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy	"Within the CMA branch, the PN type ""Substrate delivery"" denotes the step in which CMA substrates are delivered to the lysosome, which matches the GO process term for lysosomal targeting in CMA."	This mapping is specific to the CMA effector group and should not be applied to unrelated delivery or targeting categories elsewhere in the workbook.	proteostasis-workbook-2024; proteostasis-ms2
DNAJB1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate delivery		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		new_to_goa		This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
DNAJB1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate delivery		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	exact	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSPA8;DNAJB1;CLU		new_to_goa		"Within the CMA branch, the PN type ""Substrate delivery"" denotes the step in which CMA substrates are delivered to the lysosome, which matches the GO process term for lysosomal targeting in CMA."	This mapping is specific to the CMA effector group and should not be applied to unrelated delivery or targeting categories elsewhere in the workbook.	proteostasis-workbook-2024; proteostasis-ms2
CLU		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate delivery		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		entailed_by_goa_closure	GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy	This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
CLU		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate delivery		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	exact	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSPA8;DNAJB1;CLU		already_in_goa_exact	GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy	"Within the CMA branch, the PN type ""Substrate delivery"" denotes the step in which CMA substrates are delivered to the lysosome, which matches the GO process term for lysosomal targeting in CMA."	This mapping is specific to the CMA effector group and should not be applied to unrelated delivery or targeting categories elsewhere in the workbook.	proteostasis-workbook-2024; proteostasis-ms2
HSP90AA1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		already_in_goa_exact	GO:0061684 chaperone-mediated autophagy	This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
HSP90AA1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	ok_for_propagation_to_go	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSP90AA1;HSP90AB1;STUB1;STIP1;ST13		more_specific_than_existing_goa	GO:0061684 chaperone-mediated autophagy	This leaf denotes substrate-selection machinery for CMA. The GO protein-targeting term preserves the mechanistic role without relying on broad class-level CMA propagation.		proteostasis-workbook-2026; proteostasis-ms2
HSP90AB1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		new_to_goa		This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
HSP90AB1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	ok_for_propagation_to_go	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSP90AA1;HSP90AB1;STUB1;STIP1;ST13		new_to_goa		This leaf denotes substrate-selection machinery for CMA. The GO protein-targeting term preserves the mechanistic role without relying on broad class-level CMA propagation.		proteostasis-workbook-2026; proteostasis-ms2
STUB1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		already_in_goa_exact	GO:0061684 chaperone-mediated autophagy	This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
STUB1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	ok_for_propagation_to_go	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSP90AA1;HSP90AB1;STUB1;STIP1;ST13		more_specific_than_existing_goa	GO:0030163 protein catabolic process;GO:0061684 chaperone-mediated autophagy	This leaf denotes substrate-selection machinery for CMA. The GO protein-targeting term preserves the mechanistic role without relying on broad class-level CMA propagation.		proteostasis-workbook-2026; proteostasis-ms2
STIP1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		new_to_goa		This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
STIP1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	ok_for_propagation_to_go	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSP90AA1;HSP90AB1;STUB1;STIP1;ST13		new_to_goa		This leaf denotes substrate-selection machinery for CMA. The GO protein-targeting term preserves the mechanistic role without relying on broad class-level CMA propagation.		proteostasis-workbook-2026; proteostasis-ms2
ST13		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		new_to_goa		This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
ST13		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Substrate selection		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	ok_for_propagation_to_go	GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	HSP90AA1;HSP90AB1;STUB1;STIP1;ST13		new_to_goa		This leaf denotes substrate-selection machinery for CMA. The GO protein-targeting term preserves the mechanistic role without relying on broad class-level CMA propagation.		proteostasis-workbook-2026; proteostasis-ms2
LAMP2		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Receptor for chaperone-mediated autophagy	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Receptor for chaperone-mediated autophagy		autophagy_lysosome_pathway.yaml	group	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	HSPA8;DNAJB1;CLU;HSP90AA1;HSP90AB1		already_in_goa_exact	GO:0061684 chaperone-mediated autophagy	This group covers direct CMA machinery and substrate-selection effectors, unlike the broader CMA class that also includes regulators. Propagation to chaperone-mediated autophagy is appropriate at this narrower level.		proteostasis-workbook-2026; proteostasis-ms2
LAMP2		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Receptor for chaperone-mediated autophagy	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Effectors of chaperone-mediated autophagy	Receptor for chaperone-mediated autophagy		autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Receptor for chaperone-mediated autophagy	ok_for_propagation_to_go	GO:0061684	chaperone-mediated autophagy	LAMP2		already_in_goa_exact	GO:0061684 chaperone-mediated autophagy	This leaf is restricted to the lysosomal CMA receptor role, so the CMA process term is a supported process-level target.		proteostasis-workbook-2026; proteostasis-ms2
PSME1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of interaction between substrate and lysosome-p53	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of interaction between substrate and lysosome-p53	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
TP53		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of HSPA8 role in assembly of LAMP2A	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of HSPA8 role in assembly of LAMP2A	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
AMBRA1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Enhancer of substrate uptake	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Enhancer of substrate uptake	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		more_specific_than_existing_goa	GO:0010508 positive regulation of autophagy	This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
MT-RNR2		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Stabilizer of HSP90 binding of CMA substrates	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Stabilizer of HSP90 binding of CMA substrates	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
GFAP		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		more_specific_than_existing_goa	GO:1904714 regulation of chaperone-mediated autophagy	This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
EEF1A1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		more_specific_than_existing_goa	GO:1904714 regulation of chaperone-mediated autophagy	This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
EEF1A2		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		more_specific_than_existing_goa	GO:1904714 regulation of chaperone-mediated autophagy	This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
PHLPP1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
RAC1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	PSME1;TP53;AMBRA1;MT-RNR2;GFAP		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
RICTOR		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy inhibitor	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	ok_for_propagation_to_go	GO:1904715	negative regulation of chaperone-mediated autophagy	RICTOR;AKT1;CTSA		new_to_goa		This PN type explicitly records inhibitory roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
AKT1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Modulator of LAMP2A multimerization	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy inhibitor	Modulator of LAMP2A multimerization	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	ok_for_propagation_to_go	GO:1904715	negative regulation of chaperone-mediated autophagy	RICTOR;AKT1;CTSA		more_specific_than_existing_goa	GO:0010507 negative regulation of autophagy	This PN type explicitly records inhibitory roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
CTSA		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Negative regulator of CMA by degradation of LAMP2A	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Lysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy inhibitor	Negative regulator of CMA by degradation of LAMP2A	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	ok_for_propagation_to_go	GO:1904715	negative regulation of chaperone-mediated autophagy	RICTOR;AKT1;CTSA		already_in_goa_exact	GO:1904715 negative regulation of chaperone-mediated autophagy	This PN type explicitly records inhibitory roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
RAB11A		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Promotes transport of LAMP2A to the lysosome	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Extralysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy inhibitor	Promotes transport of LAMP2A to the lysosome	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	ok_for_propagation_to_go	GO:1904715	negative regulation of chaperone-mediated autophagy	RAB11A;RARA;BMAL1		new_to_goa		This PN type explicitly records inhibitory roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
RARA		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Represses transcription of CMA components	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Extralysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy inhibitor	Represses transcription of CMA components	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	ok_for_propagation_to_go	GO:1904715	negative regulation of chaperone-mediated autophagy	RAB11A;RARA;BMAL1		new_to_goa		This PN type explicitly records inhibitory roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
NCOR1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Derepresses transcription of CMA components	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Extralysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Derepresses transcription of CMA components	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	NCOR1;NFATC1		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
NFATC1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Promotes transcription of LAMP2	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Extralysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy enhancer	Promotes transcription of LAMP2	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	ok_for_propagation_to_go	GO:1904716	positive regulation of chaperone-mediated autophagy	NCOR1;NFATC1		new_to_goa		This PN type explicitly records enhancer roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
BMAL1		Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Negative regulator of transcription of CMA components	Autophagy-Lysosome Pathway	Chaperone-mediated autophagy	Extralysosomal modulator of chaperone-mediated autophagy	Chaperone-mediated autophagy inhibitor	Negative regulator of transcription of CMA components	autophagy_lysosome_pathway.yaml	type	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	ok_for_propagation_to_go	GO:1904715	negative regulation of chaperone-mediated autophagy	RAB11A;RARA;BMAL1		new_to_goa		This PN type explicitly records inhibitory roles for CMA. The directional GO regulation term is more accurate than projecting direct participation in CMA from the class ancestor.		proteostasis-workbook-2026; proteostasis-ms2
FBXO7		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|CUL1 receptor / F-box	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	CUL1 receptor / F-box	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|CUL1 receptor / F-box	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	FBXO7		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN subtype identifies a UBL-domain F-box/CUL1 receptor role. The safe shared molecular function is ubiquitin-like ligase-substrate adaptor activity rather than catalytic E3 activity.		proteostasis-workbook-2026; proteostasis-ms3
RING1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF2		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BMI1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		new_to_goa		This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		new_to_goa		This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF2		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		new_to_goa		This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF3		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		entailed_by_goa_closure	GO:0140862 histone H2AK119 ubiquitin ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF5		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		entailed_by_goa_closure	GO:0140862 histone H2AK119 ubiquitin ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF6		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / RAWUL / polycomb	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RING1;RNF2;BMI1;PCGF1;PCGF2		new_to_goa		This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UHRF1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / UHRF	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / UHRF	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / UHRF	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UHRF1;UHRF2		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UHRF2		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / UHRF	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / UHRF	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / UHRF	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UHRF1;UHRF2		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PRKN		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / Parkin	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RBR / Parkin	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / Parkin	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRKN		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RBCK1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RBR / LUBAC complex	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RBCK1;SHARPIN		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SHARPIN		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RBR / LUBAC complex	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RBCK1;SHARPIN		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RBBP6		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / other	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	E3 ligases	RING / other	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / other	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RBBP6		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RAD23A		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		already_in_goa_exact	GO:0043130 ubiquitin binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
RAD23B		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		already_in_goa_exact	GO:0043130 ubiquitin binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBQLN1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBQLN2		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBQLN3		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBQLN4		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBAC1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA, STI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBL7		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
NUB1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBA	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBTD1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBD	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBD	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBTD2		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBD	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	ubiquitin binding	UBD	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	ok_for_propagation_to_go	GO:0043130	ubiquitin binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		more_specific_than_existing_goa	GO:0005515 protein binding	This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
COBL		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|actin binding	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	non-enzymatic	actin binding	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|actin binding	ok_for_propagation_to_go	GO:0003779	actin binding	COBL;COBLL1		already_in_goa_exact	GO:0003779 actin binding	This PN subtype captures non-enzymatic UBL-domain proteins assigned to actin-binding roles. The matching GO activity term is suitable for propagation.		proteostasis-workbook-2024; proteostasis-ms3
COBLL1		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|actin binding	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	non-enzymatic	actin binding	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|actin binding	ok_for_propagation_to_go	GO:0003779	actin binding	COBL;COBLL1		already_in_goa_exact	GO:0003779 actin binding	This PN subtype captures non-enzymatic UBL-domain proteins assigned to actin-binding roles. The matching GO activity term is suitable for propagation.		proteostasis-workbook-2024; proteostasis-ms3
SDE2		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	nucleic acid processes	DNA repair	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	SDE2		new_to_goa		This PN subtype groups UBL-domain proteins in nucleic-acid-process contexts that are assigned to DNA repair. Propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
OASL		Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|double-stranded RNA binding	Ubiquitin Proteasome System	Ubiquitin and UBL proteins	UBL domain	nucleic acid processes	double-stranded RNA binding	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|double-stranded RNA binding	ok_for_propagation_to_go	GO:0003725	double-stranded RNA binding	OASL		already_in_goa_exact	GO:0003725 double-stranded RNA binding	This PN subtype captures UBL-domain proteins assigned to double-stranded RNA binding. The matching GO molecular-function term is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBA1		Ubiquitin Proteasome System|E1 activating enzymes|activation of ubiquitin	Ubiquitin Proteasome System	E1 activating enzymes	activation of ubiquitin			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of ubiquitin	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	UBA1		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group captures the canonical ubiquitin E1 activation step. The GO ubiquitin-like modifier activating enzyme activity term is the best propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBA6		Ubiquitin Proteasome System|E1 activating enzymes|activation of ubiquitin and FAT10	Ubiquitin Proteasome System	E1 activating enzymes	activation of ubiquitin and FAT10			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of ubiquitin and FAT10	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	UBA6		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of ubiquitin-family modifiers. The generic GO ubiquitin-like modifier activating enzyme activity term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBA7		Ubiquitin Proteasome System|E1 activating enzymes|activation of ISG15	Ubiquitin Proteasome System	E1 activating enzymes	activation of ISG15			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of ISG15	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	UBA7		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the ubiquitin-like modifier ISG15. The generic GO ubiquitin-like modifier activating enzyme activity term is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBA3		Ubiquitin Proteasome System|E1 activating enzymes|activation of NEDD8	Ubiquitin Proteasome System	E1 activating enzymes	activation of NEDD8			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of NEDD8	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	UBA3;NAE1		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the ubiquitin-like modifier NEDD8. The generic GO activating enzyme activity term is the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
NAE1		Ubiquitin Proteasome System|E1 activating enzymes|activation of NEDD8	Ubiquitin Proteasome System	E1 activating enzymes	activation of NEDD8			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of NEDD8	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	UBA3;NAE1		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the ubiquitin-like modifier NEDD8. The generic GO activating enzyme activity term is the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
SAE1		Ubiquitin Proteasome System|E1 activating enzymes|activation of SUMO	Ubiquitin Proteasome System	E1 activating enzymes	activation of SUMO			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of SUMO	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	SAE1;UBA2		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the SUMO modifier family. The generic GO activating enzyme activity term is the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBA2		Ubiquitin Proteasome System|E1 activating enzymes|activation of SUMO	Ubiquitin Proteasome System	E1 activating enzymes	activation of SUMO			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of SUMO	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	SAE1;UBA2		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the SUMO modifier family. The generic GO activating enzyme activity term is the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBA5		Ubiquitin Proteasome System|E1 activating enzymes|activation of UFM1	Ubiquitin Proteasome System	E1 activating enzymes	activation of UFM1			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of UFM1	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	UBA5		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the UFM1 modifier family. The generic GO activating enzyme activity term is the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
MOCS3		Ubiquitin Proteasome System|E1 activating enzymes|activation of URM1	Ubiquitin Proteasome System	E1 activating enzymes	activation of URM1			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of URM1	ok_for_propagation_to_go	GO:0008641	ubiquitin-like modifier activating enzyme activity	MOCS3		already_in_goa_exact	GO:0008641 ubiquitin-like modifier activating enzyme activity	This PN group represents E1 activation of the ubiquitin-like modifier URM1. The generic GO activating enzyme activity term is the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ATG7		Ubiquitin Proteasome System|E1 activating enzymes|activation of ATG8, ATG12	Ubiquitin Proteasome System	E1 activating enzymes	activation of ATG8, ATG12			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E1 activating enzymes|activation of ATG8, ATG12	ok_for_propagation_to_go	GO:0019778	Atg12 activating enzyme activity	ATG7		already_in_goa_exact	GO:0019778 Atg12 activating enzyme activity	This PN group captures the autophagy-related E1 activation step for ATG8 and ATG12 family members. The GO Atg12 activating enzyme activity term is the specific propagation target supported by the local ontology cache.		proteostasis-workbook-2024; proteostasis-ms3
UBE2K		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 1|UBC domain & UBA domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 1	UBC domain & UBA domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2A		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 2	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2A		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 2	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2A;UBE2B		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2B		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 2	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2B		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 2	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2A;UBE2B		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2G1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2G1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2G2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2G2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC34		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC34		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	CDC34;UBE2R2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function.		proteostasis-workbook-2024; proteostasis-ms3
UBE2R2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2R2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 3	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	CDC34;UBE2R2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2D1;UBE2D2;UBE2D3;UBE2D4		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2D1;UBE2D2;UBE2D3;UBE2D4		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D3		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D3		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2D1;UBE2D2;UBE2D3;UBE2D4		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D4		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2D4		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2D1;UBE2D2;UBE2D3;UBE2D4		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2E1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2E1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2E1;UBE2E3		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The N-terminal extension does not change the core E2 activity assignment.		proteostasis-workbook-2024; proteostasis-ms3
UBE2E3		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2E3		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2E1;UBE2E3		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The N-terminal extension does not change the core E2 activity assignment.		proteostasis-workbook-2024; proteostasis-ms3
UBE2U		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2U		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 4	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & C-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2U		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function.		proteostasis-workbook-2024; proteostasis-ms3
UBE2J1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 5	UBC domain & transmembrane domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2J1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 5	UBC domain & transmembrane domain	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2J1;UBE2J2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this membrane-anchored architecture appears as a family-specific subtype beneath the ubiquitination group. The structural specialization does not change the core conjugating activity.		proteostasis-workbook-2024; proteostasis-ms3
UBE2J2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 5	UBC domain & transmembrane domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2J2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 5	UBC domain & transmembrane domain	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2J1;UBE2J2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this membrane-anchored architecture appears as a family-specific subtype beneath the ubiquitination group. The structural specialization does not change the core conjugating activity.		proteostasis-workbook-2024; proteostasis-ms3
UBE2H		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 6|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 6	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2H		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 6|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 6	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 6|UBC domain & C-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2H		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function.		proteostasis-workbook-2024; proteostasis-ms3
UBE2N		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 9	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2N		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 9	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2N		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2T		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 9	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2T		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 9	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain & C-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2T		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function.		proteostasis-workbook-2024; proteostasis-ms3
UBE2S		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 11|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 11	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2S		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 11|UBC domain & C-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 11	UBC domain & C-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 11|UBC domain & C-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2S		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function.		proteostasis-workbook-2024; proteostasis-ms3
UBE2C		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 12|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 12	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2C		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 12|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 12	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 12|UBC domain & N-terminal extension	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2C		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The N-terminal extension does not change the core E2 activity assignment.		proteostasis-workbook-2024; proteostasis-ms3
UBE2W		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 13|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 13	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2W		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 13|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 13	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 13|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2W		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
BIRC6		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 14	E2-E3 chimera	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
BIRC6		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 14	E2-E3 chimera	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	BIRC6;UBE2O		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, E2 architectural variants are modeled as family-specific subtypes beneath the ubiquitination group. This condition-scoped subtype mapping preserves the original intent across any family carrying the E2-E3 chimera architecture.		proteostasis-workbook-2024; proteostasis-ms3
UBE2O		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 14	E2-E3 chimera	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2O		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 14	E2-E3 chimera	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	BIRC6;UBE2O		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, E2 architectural variants are modeled as family-specific subtypes beneath the ubiquitination group. This condition-scoped subtype mapping preserves the original intent across any family carrying the E2-E3 chimera architecture.		proteostasis-workbook-2024; proteostasis-ms3
UBE2L3		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 15	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2L3		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 15	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2L3;UBE2L5		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2L5		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 15	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2L5		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 15	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2L3;UBE2L5		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2Q1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17|UBC domain & RWD-like domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 17	UBC domain & RWD-like domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2Q2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17|UBC domain & RWD-like domain	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 17	UBC domain & RWD-like domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2QL1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17 homolog|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 17 homolog	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2K;UBE2A;UBE2B;UBE2G1;UBE2G2		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2QL1		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17 homolog|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination	Family 17 homolog	UBC domain only	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17 homolog|UBC domain only	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2QL1		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2E2		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation|Family 4|UBC domain & N-terminal extension	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination, ISG15ylation	Family 4	UBC domain & N-terminal extension	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2E2;UBE2L6		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group contains dual ubiquitin/ISG15 E2 enzymes. Ubiquitin conjugating enzyme activity is the shared GO molecular-function target supported for this bucket.		proteostasis-workbook-2026; proteostasis-ms3
UBE2L6		Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation|Family 15|UBC domain only	Ubiquitin Proteasome System	E2 conjugating enzymes	ubiquitination, ISG15ylation	Family 15	UBC domain only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation	ok_for_propagation_to_go	GO:0061631	ubiquitin conjugating enzyme activity	UBE2E2;UBE2L6		already_in_goa_exact	GO:0061631 ubiquitin conjugating enzyme activity	This PN group contains dual ubiquitin/ISG15 E2 enzymes. Ubiquitin conjugating enzyme activity is the shared GO molecular-function target supported for this bucket.		proteostasis-workbook-2026; proteostasis-ms3
UBE2I		Ubiquitin Proteasome System|E2 conjugating enzymes|SUMOylation|Family 7	Ubiquitin Proteasome System	E2 conjugating enzymes	SUMOylation	Family 7		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|SUMOylation	ok_for_propagation_to_go	GO:0019789	SUMO transferase activity	UBE2I		already_in_goa_exact	GO:0019789 SUMO transferase activity	This PN group captures SUMO-conjugating E2 enzymes. The local GO cache provides SUMO transferase activity as the closest supported molecular- function target.		proteostasis-workbook-2024; proteostasis-ms3
UBE2F		Ubiquitin Proteasome System|E2 conjugating enzymes|NEDDylation|Family 8	Ubiquitin Proteasome System	E2 conjugating enzymes	NEDDylation	Family 8		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|NEDDylation	ok_for_propagation_to_go	GO:0019788	NEDD8 transferase activity	UBE2F;UBE2M		already_in_goa_exact	GO:0019788 NEDD8 transferase activity	This PN group captures NEDD8-conjugating E2 enzymes. The matching GO molecular-function term is NEDD8 transferase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE2M		Ubiquitin Proteasome System|E2 conjugating enzymes|NEDDylation|Family 8	Ubiquitin Proteasome System	E2 conjugating enzymes	NEDDylation	Family 8		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|NEDDylation	ok_for_propagation_to_go	GO:0019788	NEDD8 transferase activity	UBE2F;UBE2M		already_in_goa_exact	GO:0019788 NEDD8 transferase activity	This PN group captures NEDD8-conjugating E2 enzymes. The matching GO molecular-function term is NEDD8 transferase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE2Z		Ubiquitin Proteasome System|E2 conjugating enzymes|FAT10ylation|Family 14|UBC domain & N-terminal and C-terminal extensions	Ubiquitin Proteasome System	E2 conjugating enzymes	FAT10ylation	Family 14	UBC domain & N-terminal and C-terminal extensions	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|FAT10ylation	ok_for_propagation_to_go	GO:0019787	ubiquitin-like protein transferase activity	UBE2Z		entailed_by_goa_closure	GO:0061631 ubiquitin conjugating enzyme activity	This PN group is a UBL-conjugating E2 bucket. The safest shared molecular-function target is ubiquitin-like protein transferase activity.		proteostasis-workbook-2026; proteostasis-ms3
UFC1		Ubiquitin Proteasome System|E2 conjugating enzymes|UFMylation|no family designation	Ubiquitin Proteasome System	E2 conjugating enzymes	UFMylation	no family designation		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E2 conjugating enzymes|UFMylation	ok_for_propagation_to_go	GO:0019787	ubiquitin-like protein transferase activity	UFC1		entailed_by_goa_closure	GO:0061657 UFM1 conjugating enzyme activity;GO:0071568 UFM1 transferase activity	This PN group is a UBL-conjugating E2 bucket. The safest shared molecular-function target is ubiquitin-like protein transferase activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL4A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL4B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|metazoan	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	metazoan		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|metazoan	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	metazoan		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		already_in_goa_exact	GO:0160072 ubiquitin ligase complex scaffold activity	This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, APC sununit	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	degenerate, APC sununit		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		new_to_goa		This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
CACUL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, possible CUL3 inhibitor	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin	degenerate, possible CUL3 inhibitor		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	CUL1;CUL2;CUL3;CUL4A;CUL4B		new_to_goa		This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
RBX1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBX RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBX RING			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBX RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RBX1;RNF7		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBX RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBX RING			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBX RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RBX1;RNF7		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SKP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor|Skp1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin adaptor	Skp1		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP1;DDB1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	ELOB and ELOC are excluded after gene-level review because the Elongin BC module supports cullin-ligase assembly but is not itself the substrate-receptor activity captured by GO:1990756. Substrate recognition is supplied by BC-box, VHL-box, SOCS-box, or related receptor proteins.	proteostasis-workbook-2026; proteostasis-ms3; file:human/ELOB/ELOB-ai-review.yaml; file:human/ELOC/ELOC-ai-review.yaml
DDB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor|DDB1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cullin adaptor	DDB1		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP1;DDB1		more_specific_than_existing_goa	GO:0030674 protein-macromolecule adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	ELOB and ELOC are excluded after gene-level review because the Elongin BC module supports cullin-ligase assembly but is not itself the substrate-receptor activity captured by GO:1990756. Substrate recognition is supplied by BC-box, VHL-box, SOCS-box, or related receptor proteins.	proteostasis-workbook-2026; proteostasis-ms3; file:human/ELOB/ELOB-ai-review.yaml; file:human/ELOC/ELOC-ai-review.yaml
CAND1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	CRL regulator	F-box exchange factor	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor	ok_for_propagation_to_go	GO:1990757	ubiquitin ligase activator activity	CAND1;CAND2		new_to_goa		This PN type captures CAND-family exchange factors that activate/remodel cullin-RING ligase assemblies. The closest shared GO activity is ubiquitin ligase activator activity.		proteostasis-workbook-2026; proteostasis-ms3
CAND1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	CRL regulator	F-box exchange factor	Armadillo-like	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	ok_for_propagation_to_go	GO:1990757	ubiquitin ligase activator activity	CAND1;CAND2		new_to_goa		This PN type captures CAND-family exchange factors that activate/remodel cullin-RING ligase assemblies. The closest shared GO activity is ubiquitin ligase activator activity.		proteostasis-workbook-2026; proteostasis-ms3
CAND2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	CRL regulator	F-box exchange factor	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor	ok_for_propagation_to_go	GO:1990757	ubiquitin ligase activator activity	CAND1;CAND2		new_to_goa		This PN type captures CAND-family exchange factors that activate/remodel cullin-RING ligase assemblies. The closest shared GO activity is ubiquitin ligase activator activity.		proteostasis-workbook-2026; proteostasis-ms3
CAND2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	CRL regulator	F-box exchange factor	Armadillo-like	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	ok_for_propagation_to_go	GO:1990757	ubiquitin ligase activator activity	CAND1;CAND2		new_to_goa		This PN type captures CAND-family exchange factors that activate/remodel cullin-RING ligase assemblies. The closest shared GO activity is ubiquitin ligase activator activity.		proteostasis-workbook-2026; proteostasis-ms3
GLMN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	CRL regulator	CRL inhibitor		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor	ok_for_propagation_to_go	GO:1904667	negative regulation of ubiquitin protein ligase activity	GLMN		new_to_goa		This PN type captures cullin-RING ligase inhibitors. The matching GO process target is negative regulation of ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SKP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL14		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL18		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL21P		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL22		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO33		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO41		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO38		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO39		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXL19		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR with PHD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
KDM2A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR with PHD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
KDM2B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	LRR with PHD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
BTRC		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW10B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		more_specific_than_existing_goa	GO:0003674 molecular_function	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	FBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	FBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	FBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO27		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	FBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO44		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	FBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|PI31, UBL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	PI31, UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO42		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO45		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO24		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|RCC1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	RCC1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	CASH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH, UBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	CASH, UBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO30		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	TRAF-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO40		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	TRAF-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	ZBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO43		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	ZBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBH1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|DNA helicase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	DNA helicase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|DNA helicase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	DNA helicase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
TMEM183A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
TMEM183BP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
CCNF		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ECT2L		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ELOA		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO21		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO22		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO25		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO28		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO31		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO32		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO34		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO36		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO46		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO47		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXO48		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	F-box	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
RICTOR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|non-canonical	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate receptor	non-canonical		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	SKP2;FBXL2;FBXL3;FBXL4;FBXL5		more_specific_than_existing_goa	GO:0060090 molecular adaptor activity;GO:0140767 enzyme-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
IFI27		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	SKP2 specific	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		more_specific_than_existing_goa	GO:0060090 molecular adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
MAGEA11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|MAGE	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	SKP2 specific	MAGE	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PDLIM2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|BTRC specific	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	BTRC specific		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
YPEL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	FBXL2/FBXL20 specific		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
YPEL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	FBXL2/FBXL20 specific		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
YPEL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	FBXL2/FBXL20 specific		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
YPEL4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul1 substrate adaptor	FBXL2/FBXL20 specific		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul7 substrate receptor|F-box, noncanonical contact|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul7 substrate receptor	F-box, noncanonical contact	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul7 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	FBXW8		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
VHL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|VHL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	VHL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
APPBP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FEM1A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ankyrin repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	ankyrin repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FEM1B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ankyrin repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	ankyrin repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
FEM1C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ankyrin repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	ankyrin repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
KLHDC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
KLHDC3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
KLHDC10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZYG11A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	ZER1 group / Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZYG11B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like, LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	ZER1 group / Armadillo-like, LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZER1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZER1 group / Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate adaptor	VHL box	ZER1 group / Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZSWIM4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate adaptor	VHL box	ZSWIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZSWIM5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate adaptor	VHL box	ZSWIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZSWIM6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate adaptor	VHL box	ZSWIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ZSWIM8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate adaptor	VHL box	ZSWIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
LRR1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
LRRC14		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
LRRC14B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		no_local_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
LRRC42		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAME		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF14		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF18		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF19		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF22		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF25		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF27		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PRAMEF33		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	VHL box	PRAME (with LRR)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
LRRC28		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|non-canonical|with LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	non-canonical	with LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
LRRC58		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|non-canonical|with LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul2 substrate receptor	non-canonical	with LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	VHL;APPBP2;FEM1A;FEM1B;FEM1C		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ENC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
GAN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
IPP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KEAP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL18		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL21		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL22		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL23		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL24		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL25		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL28		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL30		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL32		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL34		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL35		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL36		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL38		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL40		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL42		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
LZTR1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
RCBTB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|RCC1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	RCC1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
IBTK		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin, RCC1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	ankyrin, RCC1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
ABTB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	ankyrin	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
RHOBTB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	small GTPase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
RHOBTB2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	small GTPase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
RHOBTB3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	small GTPase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
SPOP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	MATH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
SPOPL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	MATH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	PHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	PHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	PHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	PHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
GMCL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	GCL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
GMCL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	GCL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD19		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		no_local_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
CCIN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
IVNS1ABP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KBTBD11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		no_local_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL14		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL29		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL31		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL33		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		no_local_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KLHL41		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
RCBTB2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|RCC1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	RCC1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
ABTB2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	ankyrin	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
ABTB3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	ankyrin, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
ANKFY1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	ankyrin	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
LGALS3BP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
SANBR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB-BACK, variant	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
SHKBP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	KCTD11/21 CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD21		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	KCTD11/21 CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
TNFAIP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
BTBD10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
KCTD20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / KCTD type I	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
ARMC5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / other|Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate receptor	BTB / other	Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	ENC1;GAN;IPP;KBTBD2;KBTBD3		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.	KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity.	proteostasis-workbook-2026; proteostasis-ms3; file:human/KCTD18/KCTD18-ai-review.yaml; file:human/KCTD18/KCTD18-notes.md
PDCD6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor|KLHL12 specific|EF hand	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate adaptor	KLHL12 specific	EF hand	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	PDCD6;PEF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PEF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor|KLHL12 specific|EF hand	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul3 substrate adaptor	KLHL12 specific	EF hand	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	PDCD6;PEF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
BRWD1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
BRWD3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
PHIP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|IQ motif	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	IQ motif	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|LisH, Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	LisH, Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
WDTC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
AMBRA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF4L1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF4L2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF8L1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF8L2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF12L1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF12L2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DDB2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DTL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		more_specific_than_existing_goa	GO:0030674 protein-macromolecule adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ERCC8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
COP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate adaptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	COP1;DCAF7;DCAF13;AHR;ARNT		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate adaptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	COP1;DCAF7;DCAF13;AHR;ARNT		more_specific_than_existing_goa	GO:0030674 protein-macromolecule adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate adaptor	WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	COP1;DCAF7;DCAF13;AHR;ARNT		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
CRBN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|LON, Yippee, DOC	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	LON, Yippee, DOC	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
TOR1AIP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
HOXB4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
TRPC4AP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DCAF16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DET1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate receptor	non-WD40	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	BRWD1;BRWD3;PHIP;DCAF6;DCAF1		already_in_goa_exact	GO:1990756 ubiquitin-like ligase-substrate adaptor activity	This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
DDA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold|(no type)|(no subtype)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B receptor scaffold	(no type)	(no subtype)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold	ok_for_propagation_to_go	GO:0160072	ubiquitin ligase complex scaffold activity	DDA1		new_to_goa		This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.		proteostasis-workbook-2026; proteostasis-ms3
AHR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate adaptor	AHR / ARNT / TBL3 complex	PAS	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	COP1;DCAF7;DCAF13;AHR;ARNT		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
ARNT		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate adaptor	AHR / ARNT / TBL3 complex	PAS	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	COP1;DCAF7;DCAF13;AHR;ARNT		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
TBL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	Cul4A/Cul4B substrate adaptor	AHR / ARNT / TBL3 complex	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	ok_for_propagation_to_go	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	COP1;DCAF7;DCAF13;AHR;ARNT		new_to_goa		This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.		proteostasis-workbook-2026; proteostasis-ms3
MID1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class I	COS, FN, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MID2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class I	COS, FN, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class I	COS, FN, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM36		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class I	COS, FN, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM46		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class I	COS, FN, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM67		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class I	COS, FN, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM54		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class II|COS	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class II	COS	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM55		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class II|COS	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class II	COS	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM63		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class II|COS	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class II	COS	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM42		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class III|COS, FN	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class III	COS, FN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM21		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM22		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM25		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM27		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM34		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM35		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM38		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM39		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM41		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM47		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM48		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|no CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	no CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM50		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM51G		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM58		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM60		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM62		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM64		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM64B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM64C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM65		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM69		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM72		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM75		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM77		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIML1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM43		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM43B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM49		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM49B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM49C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM49D1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM49D2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV homolog	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM51		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM68		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY - folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IV	SPRY - folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PML		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|various CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	various CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0061659 ubiquitin-like protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|various CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	various CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM31		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|various CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	various CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM40		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD & folded helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	no CTD & folded helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM52		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD & short central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	no CTD & short central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM61		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD & short central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	no CTD & short central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM73		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	no CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM74		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	no CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM56		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|TolB-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class V	TolB-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM24		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VI|PHD-type ZnF, Bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VI	PHD-type ZnF, Bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM28		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VI|PHD-type ZnF, Bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VI	PHD-type ZnF, Bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM33		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VI|PHD-type ZnF, Bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VI	PHD-type ZnF, Bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII|FIL, TolB-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VII	FIL, TolB-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII|FIL, TolB-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VII	FIL, TolB-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM71		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII|FIL, TolB-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VII	FIL, TolB-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM32		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII|TolB-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VII	TolB-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM37		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VIII|MATH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class VIII	MATH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM23		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IX|ARF, P-loop NTP hydrolase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class IX	ARF, P-loop NTP hydrolase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM45		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class X|FIL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class X	FIL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class XI|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class XI	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM59		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class XI|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / class XI	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CMYA5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & FN & SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & FN & SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MEFV		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|Pyrin, ringless, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	Pyrin, ringless, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM14		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM16L		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY & folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & SPRY & folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIML2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY & folded central helix	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & SPRY & folded central helix	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM66		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & assorted CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM29		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & assorted CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM44		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & no CTD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRIM / unclassified	ringless & no CTD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFPL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	RFPL Group 1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFPL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	RFPL Group 1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFPL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	RFPL Group 1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFPL4A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 2	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	RFPL Group 2	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFPL4AL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 2	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	RFPL Group 2	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFPL4B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	RFPL other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RSPRY1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|Armadillo	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	Armadillo	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF39		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF123		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF135		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SPRY but not TRIM	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP|BIR repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BIRC / IAP	BIR repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP|BIR repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BIRC / IAP	BIR repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP|BIR repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BIRC / IAP	BIR repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP|BIR repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BIRC / IAP	BIR repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
XIAP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP|BIR repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BIRC / IAP	BIR repeat	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BRCA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BRCA1 & associated|BRCT	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BRCA1 & associated	BRCT	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BARD1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BRCA1 & associated|BRCT	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BRCA1 & associated	BRCT	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BRAP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BRCA1 & associated|UBP-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	BRCA1 & associated	UBP-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|CBL|PTB, UBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	CBL	PTB, UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBLB		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|CBL|PTB, UBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	CBL	PTB, UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBLC		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|CBL|PTB	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	CBL	PTB	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF146		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|WWE	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Deltex	WWE	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DTX1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|WWE	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Deltex	WWE	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DTX2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|WWE	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Deltex	WWE	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DTX4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|WWE	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Deltex	WWE	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DTX3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Deltex	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DTX3L		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Deltex	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF128		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF130		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF133		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF148		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF149		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF150		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF167		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNRF4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Goliath	PA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBLL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Hakai	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Hakai		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBLL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Hakai	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Hakai		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
IRF2BP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|IRF2 binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	IRF2 binding		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
IRF2BP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|IRF2 binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	IRF2 binding		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
IRF2BPL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|IRF2 binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	IRF2 binding		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LONRF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|LON|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	LON	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LONRF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|LON|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	LON	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LONRF3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|LON|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	LON	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MKRN1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Makorin|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Makorin	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MKRN3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Makorin|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Makorin	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MKRN2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Makorin|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Makorin	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MKRN4P		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Makorin|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Makorin	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MARCHF10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MARCH	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MDM2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mdm|RanBP2-type ZNF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Mdm	RanBP2-type ZNF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MDM4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mdm|RanBP2-type ZNF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Mdm	RanBP2-type ZNF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MEX3A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MEX3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MEX3B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MEX3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MEX3C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MEX3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MEX3D		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	MEX3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MIB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mindbomb	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Mindbomb		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MIB2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mindbomb	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Mindbomb		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NFXL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	NFX	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NFX1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	NFX	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NEURL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Neuralized|SPRY / NHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Neuralized	SPRY / NHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NEURL1B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Neuralized|SPRY / NHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Neuralized	SPRY / NHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NEURL3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Neuralized|SPRY / NHR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Neuralized	SPRY / NHR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PDZRN3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|TRAF-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PDZ	TRAF-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PDZRN4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PDZ	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LNX1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PDZ	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LNX2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PDZ	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PELI1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Pellino	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Pellino		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PELI2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Pellino	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Pellino		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PELI3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Pellino	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Pellino		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PEX2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PEX|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PEX	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PEX10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PEX|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PEX	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PEX12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PEX|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	PEX	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BMI1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		entailed_by_goa_closure	GO:0140862 histone H2AK119 ubiquitin ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		entailed_by_goa_closure	GO:0140862 histone H2AK119 ubiquitin ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PCGF6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RING1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Polycomb	RAWUL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PJA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Praja	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Praja		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PJA2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Praja	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Praja		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF126		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Praja	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Praja		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF115		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Praja	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Praja		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
COP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RFWD|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	RFWD	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFWD3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RFWD|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	RFWD	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RNF20/40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	RNF20/40		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF40		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RNF20/40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	RNF20/40		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RC3H1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Roquin|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Roquin	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RC3H2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Roquin|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Roquin	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RAD18		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SAP	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SAP		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RFFL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SAP	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SAP		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF34		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SAP	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SAP		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SH3RF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SH3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SH3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SH3RF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SH3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SH3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SH3RF3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SH3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SH3		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SIAH1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SIAH / SINA|SIA TRAF-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SIAH / SINA	SIA TRAF-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SIAH2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SIAH / SINA|SIA TRAF-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SIAH / SINA	SIA TRAF-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF41		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SIAH / SINA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SIAH / SINA		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF151		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SIAH / SINA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SIAH / SINA		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|MATH/TRAF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	MATH/TRAF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|MATH/TRAF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	MATH/TRAF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|MATH/TRAF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	MATH/TRAF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|MATH/TRAF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	MATH/TRAF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|MATH/TRAF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	MATH/TRAF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZFTRAF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAF-type ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF114		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAC-1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAC-1		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF125		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAC-1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAC-1		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF138		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAC-1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAC-1		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF166		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAC-1	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	TRAC-1		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UBR|UBR CTD, UBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	UBR	UBR CTD, UBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UBR|UBR CTD, UBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	UBR	UBR CTD, UBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UBR|UBR CTD, UBR-type ZnF, TM	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	UBR	UBR CTD, UBR-type ZnF, TM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UHRF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UHRF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	UHRF		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UHRF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UHRF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	UHRF		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UNK		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Unkempt	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UNKL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	Unkempt	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
VPS18		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|non-WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	VPS-associated	non-WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
VPS8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	VPS-associated	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
VPS41		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	VPS-associated	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
VPS11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	VPS-associated	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNRF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ZNRF|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ZNRF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNRF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ZNRF|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ZNRF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNRF3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ZNRF|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ZNRF	transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF112		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|P-loop NTP hydrolase & transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	P-loop NTP hydrolase & transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SHPRH		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|helicase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	helicase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HLTF		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|helicase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	helicase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
KMT2C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	Histone-lysine N-methyltransferase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
KMT2D		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	Histone-lysine N-methyltransferase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NSD2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	Histone-lysine N-methyltransferase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BAZ1B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|kinase, bromodomain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	kinase, bromodomain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MAP3K1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|kinase, SWIM-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	kinase, SWIM-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RAG1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|RAG complex	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	second enzymatic function	RAG complex	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SUMO binding domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SUMO binding domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF111		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SUMO binding domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SUMO binding domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TOPORS		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SUMO binding domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	SUMO binding domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DZIP3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|TTC3/DZIP3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	TTC3/DZIP3	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF214		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|TTC3/DZIP3	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	TTC3/DZIP3	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TTC3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|TTC3/DZIP3, TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	TTC3/DZIP3, TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LTN1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF25		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|RWD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	RWD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MNAT1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF169		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF168		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF220		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding domain	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
AMFR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding & transmembrane|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	ubiquitin binding & transmembrane	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BFAR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF103		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF121		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF139		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF145		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF170		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF186		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNFT1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SYVN1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF180		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, nuclear envelope	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER, nuclear envelope	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF43		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, nuclear envelope, cell membrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER, nuclear envelope, cell membrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF185		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, mitochondria	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER, mitochondria	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, mitochondria, cell membrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER, mitochondria, cell membrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF122		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, Golgi	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER, Golgi	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF183		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, Golgi, lysosome	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	ER, Golgi, lysosome	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF24		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|Golgi	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	Golgi	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MUL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|mitochondria, peroxisome	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	mitochondria, peroxisome	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF152		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|lysosome	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	lysosome	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DCST1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|acrosome, secretory vescicle	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	acrosome, secretory vescicle	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF182		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|cytoplasm	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain	cytoplasm	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNFT2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF175		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF215		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF222		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF223		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF225		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF228		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	with transmembrane domain		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CNOT4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF113A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF113B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|C3H1-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	C3H1-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZSWIM2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|SWIM-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	SWIM-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|FHA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	FHA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF187		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|FHA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	FHA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NHLRC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|TOL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	TOL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LRSAM1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|LRR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	LRR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RAPSN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ARK2C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CCNB1IP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CGRRF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CHFR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MGRN1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MSL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MYLIP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NSMCE1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
OBI1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PHF7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PHRF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RBBP6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RCHY1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RLIM		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF17		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF32		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF38		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF44		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF141		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF157		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF181		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF207		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF208		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF212		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF212B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF224		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		no_local_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF227		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RUFY1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SCAF11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAIP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZFPL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNF598		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MID1;MID2;TRIM9;TRIM36;TRIM46		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PRPF19		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
WDSUB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBOX5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|RING (non-overlapping)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	RING (non-overlapping)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
STUB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE4A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE4B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PPIL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NOSIP		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|split UBOX	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	UBOX	split UBOX	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
KMT2A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD	SET	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
KMT2B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD	SET	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
AIRE		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
G2E3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ING4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
JADE2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD variant|UBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	PHD variant	UBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TMEM129		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|C4C4	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RING variant	C4C4		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	PRPF19;WDSUB1;UBOX5;STUB1;UBE4A		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MAEA		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|catalytic / RING, CRA, LisH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	catalytic / RING, CRA, LisH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RMND5A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|catalytic / RING, CRA, LisH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	catalytic / RING, CRA, LisH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RMND5B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|catalytic / RING, CRA, LisH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	catalytic / RING, CRA, LisH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0034657 GID complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
GID8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / CRA, LisH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / CRA, LisH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RANBP10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / CRA, LisH, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / CRA, LisH, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RANBP9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / CRA, LisH, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / CRA, LisH, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
WDR26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / LisH, WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / LisH, WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
MKLN1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / LisH, KELCH	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / LisH, KELCH	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ARMC8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
YPEL5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / Yippee	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / Yippee	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
GID4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FAM72A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	CTLH complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex;GO:0031461 cullin-RING ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	catalytic / RING	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / core	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	catalytic / core	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex;GO:0031461 cullin-RING ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / core	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	catalytic / core	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / DOC	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / DOC	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC10		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / DOC	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / DOC	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CDC16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC23		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CDC23		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC27		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CDC27		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CDC26		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC13		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC15		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ANAPC16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC16		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	substrate adaptor / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CDC20		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	substrate adaptor / WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CDC20B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	substrate adaptor / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CDC20B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	substrate adaptor / WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
FZR1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	substrate adaptor / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FZR1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	Anaphase Promoting Complex	substrate adaptor / WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex	ok_for_propagation_to_go	GO:0005680	anaphase-promoting complex	ANAPC11;ANAPC2;ANAPC1;ANAPC10;CDC16		already_in_goa_exact	GO:0005680 anaphase-promoting complex	In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
RNF123		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex|catalytic / RING, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	KPC complex	catalytic / RING, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
UBAC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex|noncatalytic / UBL, UBA, STI	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	KPC complex	noncatalytic / UBL, UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCL		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCA		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCE		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCB		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCC		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCF		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
FANCG		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	FANC core complex	noncatalytic / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRCA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1/BARD complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1/BARD complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BARD1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1/BARD complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1/BARD complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRCA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRCA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	catalytic / RING	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex	ok_for_propagation_to_go	GO:0070531	BRCA1-A complex	BRCA1;UIMC1;ABRAXAS1;BABAM2;BRCC3		already_in_goa_exact	GO:0070531 BRCA1-A complex	This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex.		proteostasis-workbook-2026; proteostasis-ms3
UIMC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	ubiquitin binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
UIMC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	ubiquitin binding	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex	ok_for_propagation_to_go	GO:0070531	BRCA1-A complex	BRCA1;UIMC1;ABRAXAS1;BABAM2;BRCC3		already_in_goa_exact	GO:0070531 BRCA1-A complex	This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex.		proteostasis-workbook-2026; proteostasis-ms3
ABRAXAS1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	ubiquitin binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ABRAXAS1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	ubiquitin binding	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex	ok_for_propagation_to_go	GO:0070531	BRCA1-A complex	BRCA1;UIMC1;ABRAXAS1;BABAM2;BRCC3		already_in_goa_exact	GO:0070531 BRCA1-A complex	This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex.		proteostasis-workbook-2026; proteostasis-ms3
BABAM2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	ubiquitin binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		entailed_by_goa_closure	GO:0000152 nuclear ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BABAM2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	ubiquitin binding	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex	ok_for_propagation_to_go	GO:0070531	BRCA1-A complex	BRCA1;UIMC1;ABRAXAS1;BABAM2;BRCC3		already_in_goa_exact	GO:0070531 BRCA1-A complex	This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex.		proteostasis-workbook-2026; proteostasis-ms3
BRCC3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|DUB / MPN	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	DUB / MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRCC3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|DUB / MPN	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	DUB / MPN	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex	ok_for_propagation_to_go	GO:0070531	BRCA1-A complex	BRCA1;UIMC1;ABRAXAS1;BABAM2;BRCC3		already_in_goa_exact	GO:0070531 BRCA1-A complex	This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex.		proteostasis-workbook-2026; proteostasis-ms3
BABAM1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|other / RCC1, SPRY, WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	other / RCC1, SPRY, WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BABAM1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|other / RCC1, SPRY, WD40	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-A complex	other / RCC1, SPRY, WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex	ok_for_propagation_to_go	GO:0070531	BRCA1-A complex	BRCA1;UIMC1;ABRAXAS1;BABAM2;BRCC3		already_in_goa_exact	GO:0070531 BRCA1-A complex	This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex.		proteostasis-workbook-2026; proteostasis-ms3
BRCA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-B complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
TOPBP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|BRCT	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-B complex	BRCT	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRIP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|DNA helicase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-B complex	DNA helicase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRCA1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-C complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RBBP8		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|DNA endonuclease	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-C complex	DNA endonuclease	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
MRE11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / DNA binding	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-C complex	MRN subcomplex / DNA binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RAD50		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex /  ATPase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-C complex	MRN subcomplex /  ATPase	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
NBN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex /  BRCT	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	BRCA1-C complex	MRN subcomplex /  BRCT	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
MSL2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|catalytic / RING	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	MSL1/MSL2 complex	catalytic / RING	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
MSL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|noncatalytic / other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	MSL1/MSL2 complex	noncatalytic / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RNF185		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|catalytic / RING, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	membralin complex	catalytic / RING, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
TMEM259		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	membralin complex	noncatalytic / transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
TMUB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	membralin complex	noncatalytic / transmembrane, UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
TMUB2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	membralin complex	noncatalytic / transmembrane, UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
AMFR		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|catalytic / UBOX, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	LMBR1L-GP78-UBAC2 complex	catalytic / UBOX, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
LMBR1L		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	LMBR1L-GP78-UBAC2 complex	noncatalytic / transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
UBAC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / UBA, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	LMBR1L-GP78-UBAC2 complex	noncatalytic / UBA, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RNF170		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|catalytic / RING, transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	RNF170 / ERLIN complex	catalytic / RING, transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ERLIN1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	RNF170 / ERLIN complex	noncatalytic / BAND 7	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		more_specific_than_existing_goa	GO:0032991 protein-containing complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ERLIN2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RING complex	RNF170 / ERLIN complex	noncatalytic / BAND 7	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	MAEA;RMND5A;RMND5B;GID8;RANBP10		more_specific_than_existing_goa	GO:0032991 protein-containing complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
STUB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex|catalytic / UBOX / TPR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic UBOX complex	STUB1/CHIC2 complex	catalytic / UBOX / TPR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	STUB1;CHIC2		already_in_goa_exact	GO:0000151 ubiquitin ligase complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CHIC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex|noncatalytic	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic UBOX complex	STUB1/CHIC2 complex	noncatalytic	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	STUB1;CHIC2		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
ARIH2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Ariadne	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	Ariadne		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ARIH1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Ariadne	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	Ariadne		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ANKIB1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Ariadne, ankyrin repeats, UIM	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	Ariadne, ankyrin repeats, UIM		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF31		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|PUB, RanBP2-type ZnF, UBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	PUB, RanBP2-type ZnF, UBA		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RBCK1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|UBL, RanBP2-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	UBL, RanBP2-type ZnF		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PRKN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|UBL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	UBL		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF14		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|RWD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	RWD		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL9		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Cullin, Armadillo-like	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	Cullin, Armadillo-like		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF144A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	transmembrane		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF144B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	transmembrane		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF217		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	transmembrane		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF19B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	transmembrane		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF19A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|transmembrane	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	transmembrane		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF216		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RBR	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ARIH2;ARIH1;ANKIB1;RNF31;RBCK1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF31		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|catalytic / RBR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RBR complex	LUBAC	catalytic / RBR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	RNF31;RBCK1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RNF31		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|catalytic / RBR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RBR complex	LUBAC	catalytic / RBR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	RNF31;RBCK1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN type denotes the LUBAC RBR E3 ligase complex. The safe GO propagation target is ubiquitin ligase complex.		proteostasis-workbook-2026; proteostasis-ms3
RBCK1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|catalytic / RBR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RBR complex	LUBAC	catalytic / RBR	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	RNF31;RBCK1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
RBCK1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|catalytic / RBR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RBR complex	LUBAC	catalytic / RBR	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	RNF31;RBCK1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN type denotes the LUBAC RBR E3 ligase complex. The safe GO propagation target is ubiquitin ligase complex.		proteostasis-workbook-2026; proteostasis-ms3
SHARPIN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|noncatalytic / UBL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RBR complex	LUBAC	noncatalytic / UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	RNF31;RBCK1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
SHARPIN		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|noncatalytic / UBL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic RBR complex	LUBAC	noncatalytic / UBL	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	RNF31;RBCK1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN type denotes the LUBAC RBR E3 ligase complex. The safe GO propagation target is ubiquitin ligase complex.		proteostasis-workbook-2026; proteostasis-ms3
MYCBP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RCR	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RCR			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RCR	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	MYCBP2		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF213		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ|dynein-like motor	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RZ	dynein-like motor		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF213;ZNFX1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNFX1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ|RNA helicase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	RZ	RNA helicase		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF213;ZNFX1		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ITCH		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination & NEDDylation	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination & NEDDylation	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SMURF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination & NEDDylation	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination & NEDDylation	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SMURF2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination & NEDDylation	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination & NEDDylation	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NEDD4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
NEDD4L		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
WWP1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
WWP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HECW1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HECW2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	NEDD4-type / WW & C2	ubiquitination	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|WD40, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	HERC-type / RCC1	WD40, SPRY	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|DOC	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	HERC-type / RCC1	DOC	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	HERC-type / RCC1	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	HERC-type / RCC1	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	HERC-type / RCC1	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	HERC-type / RCC1	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HACE1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|ankyrin repeats	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	ankyrin repeats		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HECTD1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|Armadillo-like, ankyrin repeats	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	Armadillo-like, ankyrin repeats		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIP12		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|Armadillo-like, WWE	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	Armadillo-like, WWE		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HUWE1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|Armadillo-like, WWE, UBA	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	Armadillo-like, WWE, UBA		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|IQ motif	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	IQ motif		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3C		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|IQ motif	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	IQ motif		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HECTD4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|transmembrane, SPRY	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	transmembrane, SPRY		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
AREL1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|FIL	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	FIL		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
G2E3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|PHD	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	PHD		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HECTD3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|DOC	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	DOC		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR5		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|UBR-type ZnF	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	UBR-type ZnF		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3A		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HECTD2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	HECT	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	ITCH;SMURF1;SMURF2;NEDD4;NEDD4L		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC6		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2|BIR repeat	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	E3 with intrinsic E2	BIR repeat		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	BIRC6;UBE2O		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE2O		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	E3 with intrinsic E2	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	BIRC6;UBE2O		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TNFAIP3		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|OTU & A20	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	OTU & A20		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		more_specific_than_existing_goa	GO:0003824 catalytic activity;GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
KAT2B		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|bromodomain, Acyl_CoA_acyltransferase	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	bromodomain, Acyl_CoA_acyltransferase		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PPARA		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	transcription factor		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PPARG		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	transcription factor		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZFP91		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|C2H2 ZnF (one cluster)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	C2H2 ZnF (one cluster)		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
E4F1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|C2H2 ZnF (two clusters)	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	C2H2 ZnF (two clusters)		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3D		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|proposed HECT variant	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	proposed HECT variant		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LMO7		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|LIM, PDZ	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	LIM, PDZ		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
C10orf90		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
OSTM1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PPP1R11		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SART1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		new_to_goa		This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRAF3IP2		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3	other		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	TNFAIP3;KAT2B;PPARA;PPARG;ZFP91		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR4		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|catalytic subunit	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3 ligase complex	UBR4/KCMF1 complex	catalytic subunit	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	UBR4;KCMF1;CALM1		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
KCMF1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|noncatalytic subunit	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3 ligase complex	UBR4/KCMF1 complex	noncatalytic subunit	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	UBR4;KCMF1;CALM1		new_to_goa		This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
CALM1		Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|noncatalytic subunit	Ubiquitin Proteasome System	E3 ubiquitin and UBL ligases	idiosyncratic E3 ligase complex	UBR4/KCMF1 complex	noncatalytic subunit	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	UBR4;KCMF1;CALM1		more_specific_than_existing_goa	GO:0032991 protein-containing complex;GO:1902494 catalytic complex	This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit.		proteostasis-workbook-2026; proteostasis-ms3
USP4		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|internal and external UBLs	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP	internal and external UBLs	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP11		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|internal and external UBLs	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP	internal and external UBLs	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP15		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|internal and external UBLs	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP	internal and external UBLs	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP32		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|internal and external UBLs	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP	internal and external UBLs	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP48		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP33		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP, UBP-ZnF	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP, UBP-ZnF		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP20		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP, UBP-ZnF	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	DUSP, UBP-ZnF		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP5		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|UBA	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP13		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|UBA	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140936 histone H2B deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP16		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP22		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140936 histone H2B deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP44		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP45		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP49		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140936 histone H2B deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP51		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	UBP-ZnF	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP37		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|PH-like|UIM	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	PH-like	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP26		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|PH-like|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	PH-like	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP29		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|PH-like|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	PH-like	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP24		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|external UBL, UBA	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Armadillo-like	external UBL, UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP9X		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Armadillo-like	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP9Y		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Armadillo-like	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP34		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Armadillo-like	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP35		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Armadillo-like	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP19		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|transmembrane|internal UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	transmembrane	internal UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP30		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|transmembrane|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	transmembrane	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP7		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|MATH-TRAF|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	MATH-TRAF	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP6		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Rab-GTPase-TBC|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Rab-GTPase-TBC	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP8		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|dimerization, rhodanese-like|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	dimerization, rhodanese-like	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP10		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Ataxin-2, C term|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Ataxin-2, C term	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
CYLD		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|CAP Gly-rich domain|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	CAP Gly-rich domain	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:0061815 Met1-linked polyubiquitin deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP14		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP47		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP40		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|external UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	external UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP31		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|internal UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	internal UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP43		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|internal UBL	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	internal UBL	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP25		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|UBA, UIM	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	UBA, UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP28		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|UBA	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP54		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP50		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP36		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140936 histone H2B deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP38		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP42		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP12		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP18		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP21		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP27X		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP46		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	other	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L5		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L6P		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L10		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L11		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L12		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L13		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L15		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L17		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L18		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L19		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L20		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L21		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L22		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L23		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L24		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L25		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L26		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L27		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L28		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L29		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
USP17L30		Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group	Ubiquitin Proteasome System	DUBs and UBL demodifiers	USP	Usp17 group		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP4;USP11;USP15;USP32;USP48		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.	The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation.	proteostasis-workbook-2026; proteostasis-ms3
UCHL1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UCH			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	UCHL1;UCHL3;UCHL5;BAP1		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
UCHL3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UCH			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	UCHL1;UCHL3;UCHL5;BAP1		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
UCHL5		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UCH			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	UCHL1;UCHL3;UCHL5;BAP1		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
BAP1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UCH			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	UCHL1;UCHL3;UCHL5;BAP1		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
PSMD14		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|proteasomal	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	proteasomal		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|proteasomal	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	PSMD14		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type captures the proteasomal JAMM/MPN deubiquitinase PSMD14/RPN11 context. The shared molecular-function target is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
COPS5		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|CSN complex	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	CSN complex		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
EIF3F		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|EIF3 complex	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	EIF3 complex		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|EIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3F;EIF3H		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type captures JAMM/MPN proteins assigned to the eIF3 complex, notably proteostasis-linked eIF3 subunits with metalloprotease-like MPN domains. The GO eIF3 complex term is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
EIF3H		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|EIF3 complex	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	EIF3 complex		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|EIF3 complex	ok_for_propagation_to_go	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3F;EIF3H		already_in_goa_exact	GO:0005852 eukaryotic translation initiation factor 3 complex	This PN type captures JAMM/MPN proteins assigned to the eIF3 complex, notably proteostasis-linked eIF3 subunits with metalloprotease-like MPN domains. The GO eIF3 complex term is the correct propagation target.		proteostasis-workbook-2024; proteostasis-ms3
STAMBP		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|USP dimerization domain	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	USP dimerization domain		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|USP dimerization domain	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	STAMBP;STAMBPL1		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
STAMBPL1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|USP dimerization domain	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	USP dimerization domain		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|USP dimerization domain	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	STAMBP;STAMBPL1		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
MYSM1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	assorted		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	MYSM1;MPND;BRCC3		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
MPND		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	assorted		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	MYSM1;MPND;BRCC3		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
BRCC3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted	Ubiquitin Proteasome System	DUBs and UBL demodifiers	JAMM / MPN	assorted		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	MYSM1;MPND;BRCC3		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
MINDY1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	Ubiquitin Proteasome System	DUBs and UBL demodifiers	MINDY			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	MINDY1;MINDY2;MINDY3;MINDY4		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
MINDY2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	Ubiquitin Proteasome System	DUBs and UBL demodifiers	MINDY			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	MINDY1;MINDY2;MINDY3;MINDY4		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
MINDY3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	Ubiquitin Proteasome System	DUBs and UBL demodifiers	MINDY			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	MINDY1;MINDY2;MINDY3;MINDY4		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
MINDY4		Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	Ubiquitin Proteasome System	DUBs and UBL demodifiers	MINDY			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	MINDY1;MINDY2;MINDY3;MINDY4		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
ATXN3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin|UIM	Ubiquitin Proteasome System	DUBs and UBL demodifiers	Josephin	UIM		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	ATXN3;ATXN3L;JOSD1;JOSD2		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
ATXN3L		Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin|UIM	Ubiquitin Proteasome System	DUBs and UBL demodifiers	Josephin	UIM		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	ATXN3;ATXN3L;JOSD1;JOSD2		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
JOSD1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin|non-UIM	Ubiquitin Proteasome System	DUBs and UBL demodifiers	Josephin	non-UIM		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	ATXN3;ATXN3L;JOSD1;JOSD2		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
JOSD2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin|non-UIM	Ubiquitin Proteasome System	DUBs and UBL demodifiers	Josephin	non-UIM		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	ATXN3;ATXN3L;JOSD1;JOSD2		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZUP1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|ZUP1|DUB	Ubiquitin Proteasome System	DUBs and UBL demodifiers	ZUP1	DUB		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|ZUP1	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	ZUP1		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
UFSP1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UFSP	deUFMylase		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP	ok_for_propagation_to_go	GO:0071567	deUFMylase activity	UFSP1;UFSP2		already_in_goa_exact	GO:0071567 deUFMylase activity	This PN group captures UFSP-family deUFMylases. The matching GO molecular-function term is deUFMylase activity.		proteostasis-workbook-2026; proteostasis-ms3
UFSP1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UFSP	deUFMylase		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase	ok_for_propagation_to_go	GO:0071567	deUFMylase activity	UFSP1;UFSP2		already_in_goa_exact	GO:0071567 deUFMylase activity	This PN type is the explicit deUFMylase bucket under UFSP proteins. The matching GO molecular-function term is deUFMylase activity.		proteostasis-workbook-2026; proteostasis-ms3
UFSP2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UFSP	deUFMylase		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP	ok_for_propagation_to_go	GO:0071567	deUFMylase activity	UFSP1;UFSP2		already_in_goa_exact	GO:0071567 deUFMylase activity	This PN group captures UFSP-family deUFMylases. The matching GO molecular-function term is deUFMylase activity.		proteostasis-workbook-2026; proteostasis-ms3
UFSP2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase	Ubiquitin Proteasome System	DUBs and UBL demodifiers	UFSP	deUFMylase		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase	ok_for_propagation_to_go	GO:0071567	deUFMylase activity	UFSP1;UFSP2		already_in_goa_exact	GO:0071567 deUFMylase activity	This PN type is the explicit deUFMylase bucket under UFSP proteins. The matching GO molecular-function term is deUFMylase activity.		proteostasis-workbook-2026; proteostasis-ms3
ATG4A		Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease|with LIR	Ubiquitin Proteasome System	DUBs and UBL demodifiers	ATG4 cysteine protease	with LIR		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This PN group is the ATG4 cysteine protease family. The shared defensible GO assertion is cysteine-type peptidase activity; autophagy-specific ATG8 processing is curated in the ALP branch.		proteostasis-workbook-2026; proteostasis-ms3
ATG4B		Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease|with LIR	Ubiquitin Proteasome System	DUBs and UBL demodifiers	ATG4 cysteine protease	with LIR		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This PN group is the ATG4 cysteine protease family. The shared defensible GO assertion is cysteine-type peptidase activity; autophagy-specific ATG8 processing is curated in the ALP branch.		proteostasis-workbook-2026; proteostasis-ms3
ATG4C		Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease|with LIR	Ubiquitin Proteasome System	DUBs and UBL demodifiers	ATG4 cysteine protease	with LIR		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This PN group is the ATG4 cysteine protease family. The shared defensible GO assertion is cysteine-type peptidase activity; autophagy-specific ATG8 processing is curated in the ALP branch.		proteostasis-workbook-2026; proteostasis-ms3
ATG4D		Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease|lacking LIR	Ubiquitin Proteasome System	DUBs and UBL demodifiers	ATG4 cysteine protease	lacking LIR		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease	ok_for_propagation_to_go	GO:0008234	cysteine-type peptidase activity	ATG4A;ATG4B;ATG4C;ATG4D		already_in_goa_exact	GO:0008234 cysteine-type peptidase activity	This PN group is the ATG4 cysteine protease family. The shared defensible GO assertion is cysteine-type peptidase activity; autophagy-specific ATG8 processing is curated in the ALP branch.		proteostasis-workbook-2026; proteostasis-ms3
SENP8		Ubiquitin Proteasome System|DUBs and UBL demodifiers|SENP|deNEDDylase, NEDD8 processing	Ubiquitin Proteasome System	DUBs and UBL demodifiers	SENP	deNEDDylase, NEDD8 processing		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|SENP|deNEDDylase, NEDD8 processing	ok_for_propagation_to_go	GO:0019784	deNEDDylase activity	SENP8		already_in_goa_exact	GO:0019784 deNEDDylase activity	This PN type is the SENP8/NEDD8-processing bucket. The matching GO molecular-function term is deNEDDylase activity.		proteostasis-workbook-2026; proteostasis-ms3
COPS5		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|MPN, catalytic subunit	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	MPN, catalytic subunit	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS5		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|MPN, catalytic subunit	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	MPN, catalytic subunit	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS6		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|MPN, noncatalytic subunit	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	MPN, noncatalytic subunit	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS6		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|MPN, noncatalytic subunit	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	MPN, noncatalytic subunit	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS4		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS4		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS7A		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS7A		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS7B		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS7B		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS8		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS8		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
GPS1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
GPS1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
COPS9		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome.		proteostasis-workbook-2026; proteostasis-ms3
COPS9		Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|other	Ubiquitin Proteasome System	DUBs and UBL demodifiers	CSN complex	deNEDDylase	other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase	ok_for_propagation_to_go	GO:0008180	COP9 signalosome	COPS5;COPS6;COPS2;COPS3;COPS4		already_in_goa_exact	GO:0008180 COP9 signalosome	This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit.		proteostasis-workbook-2026; proteostasis-ms3
BRCC3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|catalytic subunit|JAMM / MPN	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	catalytic subunit	JAMM / MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex	ok_for_propagation_to_go	GO:0070552	BRISC complex	BRCC3;ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN group denotes BRISC complex members. The matching GO cellular-component term is BRISC complex.		proteostasis-workbook-2026; proteostasis-ms3
BRCC3		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|catalytic subunit|JAMM / MPN	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	catalytic subunit	JAMM / MPN	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|catalytic subunit	ok_for_propagation_to_go	GO:0140492	metal-dependent deubiquitinase activity	BRCC3		already_in_goa_exact	GO:0140492 metal-dependent deubiquitinase activity	This PN type is the catalytic JAMM/MPN subunit of the BRISC complex. The shared molecular function is metal-dependent deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
ABRAXAS2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|JAMM / MPN / ubiquitin binding	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	noncatalytic	JAMM / MPN / ubiquitin binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex	ok_for_propagation_to_go	GO:0070552	BRISC complex	BRCC3;ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN group denotes BRISC complex members. The matching GO cellular-component term is BRISC complex.		proteostasis-workbook-2026; proteostasis-ms3
ABRAXAS2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|JAMM / MPN / ubiquitin binding	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	noncatalytic	JAMM / MPN / ubiquitin binding	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic	ok_for_propagation_to_go	GO:0070552	BRISC complex	ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN type covers noncatalytic BRISC subunits, so complex membership is the safe propagation target rather than catalytic DUB activity.		proteostasis-workbook-2026; proteostasis-ms3
BABAM2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|ubiquitin binding	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	noncatalytic	ubiquitin binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex	ok_for_propagation_to_go	GO:0070552	BRISC complex	BRCC3;ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN group denotes BRISC complex members. The matching GO cellular-component term is BRISC complex.		proteostasis-workbook-2026; proteostasis-ms3
BABAM2		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|ubiquitin binding	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	noncatalytic	ubiquitin binding	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic	ok_for_propagation_to_go	GO:0070552	BRISC complex	ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN type covers noncatalytic BRISC subunits, so complex membership is the safe propagation target rather than catalytic DUB activity.		proteostasis-workbook-2026; proteostasis-ms3
BABAM1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|other / RCC1, SPRY, WD40	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	noncatalytic	other / RCC1, SPRY, WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex	ok_for_propagation_to_go	GO:0070552	BRISC complex	BRCC3;ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN group denotes BRISC complex members. The matching GO cellular-component term is BRISC complex.		proteostasis-workbook-2026; proteostasis-ms3
BABAM1		Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|other / RCC1, SPRY, WD40	Ubiquitin Proteasome System	DUBs and UBL demodifiers	BRISC complex	noncatalytic	other / RCC1, SPRY, WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic	ok_for_propagation_to_go	GO:0070552	BRISC complex	ABRAXAS2;BABAM2;BABAM1		already_in_goa_exact	GO:0070552 BRISC complex	This PN type covers noncatalytic BRISC subunits, so complex membership is the safe propagation target rather than catalytic DUB activity.		proteostasis-workbook-2026; proteostasis-ms3
PSMA1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA7		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA7		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA8		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	specialized	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMA8		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	alpha subunit	specialized	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit	ok_for_propagation_to_go	GO:0019773	proteasome core complex, alpha-subunit complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0019773 proteasome core complex, alpha-subunit complex	This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB7		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB7		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	constitutive	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB8		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB8		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB9		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB9		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB10		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB10		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB11		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit	ok_for_propagation_to_go	GO:0005839	proteasome core complex	PSMA1;PSMA2;PSMA3;PSMA4;PSMA5		already_in_goa_exact	GO:0005839 proteasome core complex	This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMB11		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome core particle subunit	beta subunit	specialized	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit	ok_for_propagation_to_go	GO:0019774	proteasome core complex, beta-subunit complex	PSMB1;PSMB2;PSMB3;PSMB4;PSMB5		already_in_goa_exact	GO:0019774 proteasome core complex, beta-subunit complex	This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMC1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMC1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMC2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMC2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMC3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMC3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMC4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMC4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMC5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMC5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMC6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMC6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, ATPase	with OB domain	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMD1;PSMD2;PSMD4;ADRM1		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMD1;PSMD2;PSMD4;ADRM1		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|VWA, UIM	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	VWA, UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|VWA, UIM	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	VWA, UIM	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMD1;PSMD2;PSMD4;ADRM1		already_in_goa_exact	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
ADRM1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|PRU, DEUBAD	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	PRU, DEUBAD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
ADRM1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|PRU, DEUBAD	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	base, nonATPase	PRU, DEUBAD	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase	ok_for_propagation_to_go	GO:0008540	proteasome regulatory particle, base subcomplex	PSMD1;PSMD2;PSMD4;ADRM1		more_specific_than_existing_goa	GO:0000502 proteasome complex	This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD7		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|MPN	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD7		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|MPN	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	MPN	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD14		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|MPN	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD14		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|MPN	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	MPN	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD6		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		more_specific_than_existing_goa	GO:0000502 proteasome complex;GO:0005838 proteasome regulatory particle;GO:0022624 proteasome accessory complex;GO:0032991 protein-containing complex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD11		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD11		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD8		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD8		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD12		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD12		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD13		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD13		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	PCI	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
SEM1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|SEM1	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	SEM1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMC1;PSMC2;PSMC3;PSMC4;PSMC5		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
SEM1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|SEM1	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome regulatory particle subunit	lid, nonATPase	SEM1	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	ok_for_propagation_to_go	GO:0008541	proteasome regulatory particle, lid subcomplex	PSMD7;PSMD14;PSMD3;PSMD6;PSMD11		already_in_goa_exact	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex.		proteostasis-workbook-2026; proteostasis-ms3
POMP		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
POMP		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN type denotes assembly chaperones for the proteasome core particle. The GO proteasome assembly process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PSMG1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMG1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN type denotes assembly chaperones for the proteasome core particle. The GO proteasome assembly process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PSMG2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMG2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN type denotes assembly chaperones for the proteasome core particle. The GO proteasome assembly process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PSMG3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMG3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN type denotes assembly chaperones for the proteasome core particle. The GO proteasome assembly process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PSMG4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMG4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	core particle		ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN type denotes assembly chaperones for the proteasome core particle. The GO proteasome assembly process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PSMD5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		already_in_goa_exact	GO:0043248 proteasome assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMD5		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	PSMD5;PSMD9;PSMD10;PAAF1		already_in_goa_exact	GO:0043248 proteasome assembly	This PN type denotes assembly chaperones for the proteasome regulatory particle. The local GO cache does not expose a regulatory-particle assembly term, so the broader proteasome assembly process is the correct conservative target.		proteostasis-workbook-2024; proteostasis-ms3
PSMD9		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|PDZ	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	PDZ	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		entailed_by_goa_closure	GO:0070682 proteasome regulatory particle assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMD9		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|PDZ	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	PDZ	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	PSMD5;PSMD9;PSMD10;PAAF1		entailed_by_goa_closure	GO:0070682 proteasome regulatory particle assembly	This PN type denotes assembly chaperones for the proteasome regulatory particle. The local GO cache does not expose a regulatory-particle assembly term, so the broader proteasome assembly process is the correct conservative target.		proteostasis-workbook-2024; proteostasis-ms3
PSMD10		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|ankyrin	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	ankyrin	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		entailed_by_goa_closure	GO:0070682 proteasome regulatory particle assembly	This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PSMD10		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|ankyrin	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	ankyrin	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	PSMD5;PSMD9;PSMD10;PAAF1		entailed_by_goa_closure	GO:0070682 proteasome regulatory particle assembly	This PN type denotes assembly chaperones for the proteasome regulatory particle. The local GO cache does not expose a regulatory-particle assembly term, so the broader proteasome assembly process is the correct conservative target.		proteostasis-workbook-2024; proteostasis-ms3
PAAF1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|WD40	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone	ok_for_propagation_to_go	GO:0043248	proteasome assembly	POMP;PSMG1;PSMG2;PSMG3;PSMG4		new_to_goa		This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly.		proteostasis-workbook-2026; proteostasis-ms3
PAAF1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|WD40	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome assembly chaperone	regulatory particle	WD40	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle	ok_for_propagation_to_go	GO:0043248	proteasome assembly	PSMD5;PSMD9;PSMD10;PAAF1		new_to_goa		This PN type denotes assembly chaperones for the proteasome regulatory particle. The local GO cache does not expose a regulatory-particle assembly term, so the broader proteasome assembly process is the correct conservative target.		proteostasis-workbook-2024; proteostasis-ms3
PSME1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	activator, AAA	PA28	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME1;PSME2;PSME3		new_to_goa		In `4.3.11`, the proteasome activator bucket is now the AAA-type activator subtype under proteasome activators and inhibitors. The local GO cache does not expose a proteasome-activator activity term, so proteasome binding is the most conservative supported target.		proteostasis-workbook-2024; proteostasis-ms3
PSME2		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	activator, AAA	PA28	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME1;PSME2;PSME3		new_to_goa		In `4.3.11`, the proteasome activator bucket is now the AAA-type activator subtype under proteasome activators and inhibitors. The local GO cache does not expose a proteasome-activator activity term, so proteasome binding is the most conservative supported target.		proteostasis-workbook-2024; proteostasis-ms3
PSME3		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	activator, AAA	PA28	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME1;PSME2;PSME3		new_to_goa		In `4.3.11`, the proteasome activator bucket is now the AAA-type activator subtype under proteasome activators and inhibitors. The local GO cache does not expose a proteasome-activator activity term, so proteasome binding is the most conservative supported target.		proteostasis-workbook-2024; proteostasis-ms3
PSME4		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	modulator	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME4;ECPAS;PITHD1;PSMF1		already_in_goa_exact	GO:0070628 proteasome binding	The earlier inhibitor bucket is no longer present in `4.3.11`; the surviving coarse category is proteasome modulator. The local GO cache lacks a specific proteasome-modulator activity term, so proteasome binding is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms3
ECPAS		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	modulator	Armadillo-like	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME4;ECPAS;PITHD1;PSMF1		already_in_goa_exact	GO:0070628 proteasome binding	The earlier inhibitor bucket is no longer present in `4.3.11`; the surviving coarse category is proteasome modulator. The local GO cache lacks a specific proteasome-modulator activity term, so proteasome binding is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PITHD1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|PITH	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	modulator	PITH	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME4;ECPAS;PITHD1;PSMF1		new_to_goa		The earlier inhibitor bucket is no longer present in `4.3.11`; the surviving coarse category is proteasome modulator. The local GO cache lacks a specific proteasome-modulator activity term, so proteasome binding is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms3
PSMF1		Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|PI31	Ubiquitin Proteasome System	Proteasome and associated proteins	proteasome activators and inhibitors	modulator	PI31	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator	ok_for_propagation_to_go	GO:0070628	proteasome binding	PSME4;ECPAS;PITHD1;PSMF1		already_in_goa_exact	GO:0070628 proteasome binding	The earlier inhibitor bucket is no longer present in `4.3.11`; the surviving coarse category is proteasome modulator. The local GO cache lacks a specific proteasome-modulator activity term, so proteasome binding is the conservative propagation target.		proteostasis-workbook-2024; proteostasis-ms3
USP14		Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB|USP	Ubiquitin Proteasome System	Proteasome and associated proteins	associated DUB	USP		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP14;USP15;UCHL5		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group captures proteasome-associated deubiquitinases. The shared molecular-function target is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
USP15		Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB|USP	Ubiquitin Proteasome System	Proteasome and associated proteins	associated DUB	USP		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP14;USP15;UCHL5		already_in_goa_exact	GO:0101005 deubiquitinase activity	This PN group captures proteasome-associated deubiquitinases. The shared molecular-function target is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
UCHL5		Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB|UCH	Ubiquitin Proteasome System	Proteasome and associated proteins	associated DUB	UCH		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB	ok_for_propagation_to_go	GO:0101005	deubiquitinase activity	USP14;USP15;UCHL5		entailed_by_goa_closure	GO:0004843 cysteine-type deubiquitinase activity	This PN group captures proteasome-associated deubiquitinases. The shared molecular-function target is deubiquitinase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3A		Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|HECT	Ubiquitin Proteasome System	Proteasome and associated proteins	associated E3 ligase	HECT		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE3A;UBE3C;TRIP12;PRKN;UBR1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3C		Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|HECT	Ubiquitin Proteasome System	Proteasome and associated proteins	associated E3 ligase	HECT		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE3A;UBE3C;TRIP12;PRKN;UBR1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIP12		Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|HECT|Armadillo-like	Ubiquitin Proteasome System	Proteasome and associated proteins	associated E3 ligase	HECT	Armadillo-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE3A;UBE3C;TRIP12;PRKN;UBR1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PRKN		Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|RING, UBL	Ubiquitin Proteasome System	Proteasome and associated proteins	associated E3 ligase	RING, UBL		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE3A;UBE3C;TRIP12;PRKN;UBR1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR1		Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|UBR|UBR-type ZnF	Ubiquitin Proteasome System	Proteasome and associated proteins	associated E3 ligase	UBR	UBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE3A;UBE3C;TRIP12;PRKN;UBR1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR2		Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|UBR|UBR-type ZnF	Ubiquitin Proteasome System	Proteasome and associated proteins	associated E3 ligase	UBR	UBR-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	UBE3A;UBE3C;TRIP12;PRKN;UBR1		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
AKIRIN1		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	Akirin		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
AKIRIN2		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	Akirin		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND1		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|other	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	AN1	other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND2A		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UBZ	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	AN1	UBZ	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND2B		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UIM	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	AN1	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND5		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|A20	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	AN1	A20	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
OAZ1		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|antizyme	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	antizyme		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
BAG2		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|BAG	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	BAG		ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
MIDN		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	UBL only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
SACS		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	UBL only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLNL		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	UBL only	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
RAD23A		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
RAD23B		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN1		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN2		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN3		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN4		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		new_to_goa		This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBAC1		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	UBL	with UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
SQSTM1		Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|PB1|UBA	Ubiquitin Proteasome System	Proteasome and associated proteins	adaptors	PB1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	ok_for_propagation_to_go	GO:0070628	proteasome binding	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		more_specific_than_existing_goa	GO:0044877 protein-containing complex binding	This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
VCP		Ubiquitin Proteasome System|VCP and associated proteins|VCP	Ubiquitin Proteasome System	VCP and associated proteins	VCP			ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|VCP and associated proteins|VCP	ok_for_propagation_to_go	GO:0043335	protein unfolding	VCP		already_in_goa_exact	GO:0043335 protein unfolding	This PN group is the VCP/p97 segregase node. The defensible shared GO target for VCP itself is protein unfolding.		proteostasis-workbook-2026; proteostasis-ms3
NPLOC4		Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|MPN|UBXL	Ubiquitin Proteasome System	VCP and associated proteins	associated DUBs	MPN	UBXL	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|MPN|UBXL	ok_for_propagation_to_go	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	NPLOC4		already_in_goa_exact	GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex	This PN subtype identifies NPLOC4 in the VCP-NPL4-UFD1 complex context. The safe GO target is VCP-NPL4-UFD1 AAA ATPase complex, not DUB activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF31		Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RBR|PUB, UBA	Ubiquitin Proteasome System	VCP and associated proteins	associated E3 ligases	RBR	PUB, UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF31;AMFR;SYVN1;RNF125;UBE4B		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures VCP-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
AMFR		Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING|VIM & transmembrane	Ubiquitin Proteasome System	VCP and associated proteins	associated E3 ligases	RING	VIM & transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF31;AMFR;SYVN1;RNF125;UBE4B		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures VCP-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
SYVN1		Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING|VBM & transmembrane	Ubiquitin Proteasome System	VCP and associated proteins	associated E3 ligases	RING	VBM & transmembrane	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF31;AMFR;SYVN1;RNF125;UBE4B		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures VCP-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF125		Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING|TRAC-1	Ubiquitin Proteasome System	VCP and associated proteins	associated E3 ligases	RING	TRAC-1	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF31;AMFR;SYVN1;RNF125;UBE4B		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures VCP-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE4B		Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|UBOX|VBM	Ubiquitin Proteasome System	VCP and associated proteins	associated E3 ligases	UBOX	VBM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	RNF31;AMFR;SYVN1;RNF125;UBE4B		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures VCP-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UFD1		Ubiquitin Proteasome System|VCP and associated proteins|adaptors|SHP|UT3	Ubiquitin Proteasome System	VCP and associated proteins	adaptors	SHP	UT3	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|VCP and associated proteins|adaptors|SHP|UT3	ok_for_propagation_to_go	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	UFD1		already_in_goa_exact	GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex	This PN subtype identifies UFD1 in the canonical VCP-NPL4-UFD1 adaptor complex. The matching GO cellular-component term is VCP-NPL4-UFD1 AAA ATPase complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / alpha solenoid	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / alpha solenoid	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits	ok_for_propagation_to_go	GO:0000502	proteasome complex	PSMD2;PSMD4;PSMD14;ADRM1		already_in_goa_exact	GO:0000502 proteasome complex	This PN group captures ubiquitin/UBL-binding proteasomal subunits. The shared GO target is proteasome complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / alpha solenoid	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / alpha solenoid	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD2;PSMD4;PSMD14;ADRM1		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / alpha solenoid	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / alpha solenoid	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / alpha solenoid	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD2		already_in_goa_exact	GO:0005838 proteasome regulatory particle	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|UIM, idiosyncratic Ub binding / VWA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	UIM, idiosyncratic Ub binding / VWA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits	ok_for_propagation_to_go	GO:0000502	proteasome complex	PSMD2;PSMD4;PSMD14;ADRM1		already_in_goa_exact	GO:0000502 proteasome complex	This PN group captures ubiquitin/UBL-binding proteasomal subunits. The shared GO target is proteasome complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|UIM, idiosyncratic Ub binding / VWA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	UIM, idiosyncratic Ub binding / VWA	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD2;PSMD4;PSMD14;ADRM1		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|UIM, idiosyncratic Ub binding / VWA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	UIM, idiosyncratic Ub binding / VWA	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|UIM, idiosyncratic Ub binding / VWA	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD4		entailed_by_goa_closure	GO:0008540 proteasome regulatory particle, base subcomplex	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD14		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / MPN	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits	ok_for_propagation_to_go	GO:0000502	proteasome complex	PSMD2;PSMD4;PSMD14;ADRM1		already_in_goa_exact	GO:0000502 proteasome complex	This PN group captures ubiquitin/UBL-binding proteasomal subunits. The shared GO target is proteasome complex.		proteostasis-workbook-2026; proteostasis-ms3
PSMD14		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / MPN	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / MPN	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD2;PSMD4;PSMD14;ADRM1		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
PSMD14		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / MPN	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / MPN	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / MPN	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD14		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
ADRM1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / PRU	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / PRU	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits	ok_for_propagation_to_go	GO:0000502	proteasome complex	PSMD2;PSMD4;PSMD14;ADRM1		already_in_goa_exact	GO:0000502 proteasome complex	This PN group captures ubiquitin/UBL-binding proteasomal subunits. The shared GO target is proteasome complex.		proteostasis-workbook-2026; proteostasis-ms3
ADRM1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / PRU	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / PRU	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	PSMD2;PSMD4;PSMD14;ADRM1		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
ADRM1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / PRU	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasomal subunits	regulatory particle	idiosyncratic Ub binding / PRU	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / PRU	ok_for_propagation_to_go	GO:0005838	proteasome regulatory particle	ADRM1		entailed_by_goa_closure	GO:0008541 proteasome regulatory particle, lid subcomplex	This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle.		proteostasis-workbook-2026; proteostasis-ms3
RAD23A		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL, STI1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
RAD23B		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL, STI1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL, STI1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL, STI1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL, STI1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBQLN4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL, STI1	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBAC1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL|UBA, STI	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with UBL	UBA, STI	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		already_in_goa_exact	GO:0070628 proteasome binding	This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND2A		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|UBZ (ZFAND2A/B)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with AN1	UBZ (ZFAND2A/B)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND5		Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|A20 ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	proteasome adaptor	with AN1	A20 ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
ZFAND2B		Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor|with AN1|UIM, UBZ (ZFAND2A/B)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	VCP and proteasome adaptor	with AN1	UIM, UBZ (ZFAND2A/B)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor	ok_for_propagation_to_go	GO:0070628	proteasome binding	ZFAND2B		new_to_goa		This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target.		proteostasis-workbook-2026; proteostasis-ms3
UBE2I		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme for SUMO|Family 7|backside SUMO binding	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E2 conjugating enzyme for SUMO	Family 7	backside SUMO binding	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme for SUMO	ok_for_propagation_to_go	GO:0019789	SUMO transferase activity	UBE2I		already_in_goa_exact	GO:0019789 SUMO transferase activity	This PN group identifies the SUMO E2 conjugating enzyme bucket. The matching GO molecular-function target is SUMO transferase activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	CUL1 receptor	idiosyncratic Ub binding / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		new_to_goa		This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW7		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	CUL1 receptor	idiosyncratic Ub binding / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		new_to_goa		This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
FBXW8		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	CUL1 receptor	idiosyncratic Ub binding / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		new_to_goa		This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ASB2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL5 receptor|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	CUL5 receptor	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
PML		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class V|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / TRIM class V	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		more_specific_than_existing_goa	GO:0061659 ubiquitin-like protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TRIM5		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class IV|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / TRIM class IV	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BRAP		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BRCA1 & associated|UBP-associated ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / BRCA1 & associated	UBP-associated ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BARD1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BRCA1 & associated|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / BRCA1 & associated	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BIRC, IAP|UBA (BIRC2/3)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / BIRC, IAP	UBA (BIRC2/3)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BIRC, IAP|UBA (BIRC2/3)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / BIRC, IAP	UBA (BIRC2/3)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
BIRC8		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BIRC, IAP|UBA (BIRC2/3)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / BIRC, IAP	UBA (BIRC2/3)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
XIAP		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BIRC, IAP|UBA (BIRC2/3)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / BIRC, IAP	UBA (BIRC2/3)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBL		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / CBL|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / CBL	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CBLB		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / CBL|UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / CBL	UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MDM2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Mdm|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / Mdm	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MDM4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Mdm|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / Mdm	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		new_to_goa		This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF126		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Praja|idiosyncratic Ub binding / zinc ribbon	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / Praja	idiosyncratic Ub binding / zinc ribbon	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF115		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Praja|idiosyncratic Ub binding / zinc ribbon	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / Praja	idiosyncratic Ub binding / zinc ribbon	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RAD18		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SAP|UBZ4-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / SAP	UBZ4-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF114		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRAC-1|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / TRAC-1	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF125		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRAC-1|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / TRAC-1	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF138		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRAC-1|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / TRAC-1	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF166		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRAC-1|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / TRAC-1	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNRF1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / ZNRF|UBZ (ZNRF1/2)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / ZNRF	UBZ (ZNRF1/2)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ZNRF2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / ZNRF|UBZ (ZNRF1/2)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / ZNRF	UBZ (ZNRF1/2)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
MNAT1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / second enzymatic function|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / second enzymatic function	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		new_to_goa		This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SUMO binding domain|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / SUMO binding domain	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF111		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SUMO binding domain|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / SUMO binding domain	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TOPORS		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SUMO binding domain|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / SUMO binding domain	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF168		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|MIU	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	MIU	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF169		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|MIU	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	MIU	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
DZIP3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBA-like (other)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	UBA-like (other)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF214		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBA-like (other)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	UBA-like (other)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		more_specific_than_existing_goa	GO:0004842 ubiquitin-protein transferase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
TTC3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBA-like (other)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	UBA-like (other)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF220		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBZ (RNF220)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	UBZ (RNF220)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
LTN1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|RWD (LTN1)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	RWD (LTN1)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF25		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|RWD	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD	RWD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
AMFR		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD & TM|CUE	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING / with UBD & TM	CUE	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE4B		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING variant / UBOX|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RING variant / UBOX	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HUWE1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / Armadillo-like, WW|UIM, UBM, UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	HECT / Armadillo-like, WW	UIM, UBM, UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
HERC2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / HERC-type / RCC1|ZZ Zinc finger (SUMO binding), UBA	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	HECT / HERC-type / RCC1	ZZ Zinc finger (SUMO binding), UBA	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBR5		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / RCC1|UBR-type ZnF, CUE (UBR5)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	HECT / RCC1	UBR-type ZnF, CUE (UBR5)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE3C		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / with IQ|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	HECT / with IQ	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
CUL9		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Cullin|UBA-like (ARIH1)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / Cullin	UBA-like (ARIH1)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ANKIB1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Ariadne|UIM, UBA-like (ARIH1)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / Ariadne	UIM, UBA-like (ARIH1)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ARIH1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Ariadne|UBA-like (ARIH1)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / Ariadne	UBA-like (ARIH1)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ARIH2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Ariadne|UBA-like (ARIH1)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / Ariadne	UBA-like (ARIH1)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RBCK1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / LUBAC|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / LUBAC	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF31		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / PUB|UBA, RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / PUB	UBA, RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF14		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / with UBD|RWD	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / with UBD	RWD	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
RNF216		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / with UBD|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	RBR / with UBD	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
UBE2O		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|E3 with intrinsic E2|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase	E3 with intrinsic E2	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	ok_for_propagation_to_go	GO:0061630	ubiquitin protein ligase activity	FBXW4;FBXW7;FBXW8;ASB2;PML		already_in_goa_exact	GO:0061630 ubiquitin protein ligase activity	This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|APC / catalytic subunit|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase complex component	APC / catalytic subunit	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	ANAPC2;ANAPC11;FANCL;KCMF1;SHARPIN		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex;GO:0031461 cullin-RING ubiquitin ligase complex	This PN group captures E3 ligase complex components. The safe shared GO target is ubiquitin ligase complex membership.		proteostasis-workbook-2026; proteostasis-ms3
ANAPC11		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|APC / catalytic subunit|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase complex component	APC / catalytic subunit	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	ANAPC2;ANAPC11;FANCL;KCMF1;SHARPIN		entailed_by_goa_closure	GO:0005680 anaphase-promoting complex;GO:0031461 cullin-RING ubiquitin ligase complex	This PN group captures E3 ligase complex components. The safe shared GO target is ubiquitin ligase complex membership.		proteostasis-workbook-2026; proteostasis-ms3
FANCL		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|FANC / catalytic subunit|idiosyncratic Ub binding / ELF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase complex component	FANC / catalytic subunit	idiosyncratic Ub binding / ELF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	ANAPC2;ANAPC11;FANCL;KCMF1;SHARPIN		new_to_goa		This PN group captures E3 ligase complex components. The safe shared GO target is ubiquitin ligase complex membership.		proteostasis-workbook-2026; proteostasis-ms3
KCMF1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|idiosyncratic / noncatalytic|UBZ (Di19)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase complex component	idiosyncratic / noncatalytic	UBZ (Di19)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	ANAPC2;ANAPC11;FANCL;KCMF1;SHARPIN		new_to_goa		This PN group captures E3 ligase complex components. The safe shared GO target is ubiquitin ligase complex membership.		proteostasis-workbook-2026; proteostasis-ms3
SHARPIN		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|LUBAC|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase complex component	LUBAC	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	ok_for_propagation_to_go	GO:0000151	ubiquitin ligase complex	ANAPC2;ANAPC11;FANCL;KCMF1;SHARPIN		entailed_by_goa_closure	GO:0071797 LUBAC complex	This PN group captures E3 ligase complex components. The safe shared GO target is ubiquitin ligase complex membership.		proteostasis-workbook-2026; proteostasis-ms3
N4BP1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor|ITCH inhibitor|UBA (N4BP1)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	E3 ligase inhibitor	ITCH inhibitor	UBA (N4BP1)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor	ok_for_propagation_to_go	GO:1990948	ubiquitin ligase inhibitor activity	N4BP1		new_to_goa		This PN group captures UPS factors that inhibit E3 ligases. The matching GO activity term ubiquitin ligase inhibitor activity is the best supported propagation target.		proteostasis-workbook-2024; proteostasis-ms3
AUP1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|CUE	Ubiquitin Proteasome System	Ubiquitin and UBL binding	protein quality control	ERAD cofactor	CUE	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor	ok_for_propagation_to_go	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	AUP1;UFD1		more_specific_than_existing_goa	GO:0036503 ERAD pathway	This PN type groups ubiquitin/UBL-binding factors that act as ERAD cofactors in protein-quality-control contexts. The best available GO target in the local cache is ubiquitin-dependent glycoprotein ERAD pathway, used here at propagation scope.		proteostasis-workbook-2024; proteostasis-ms3
UFD1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|idiosyncratic Ub binding / UT3	Ubiquitin Proteasome System	Ubiquitin and UBL binding	protein quality control	ERAD cofactor	idiosyncratic Ub binding / UT3	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor	ok_for_propagation_to_go	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	AUP1;UFD1		more_specific_than_existing_goa	GO:0036503 ERAD pathway	This PN type groups ubiquitin/UBL-binding factors that act as ERAD cofactors in protein-quality-control contexts. The best available GO target in the local cache is ubiquitin-dependent glycoprotein ERAD pathway, used here at propagation scope.		proteostasis-workbook-2024; proteostasis-ms3
WDR59		Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|GATOR2 complex|RWD	Ubiquitin Proteasome System	Ubiquitin and UBL binding	protein kinases & regulators	GATOR2 complex	RWD	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|GATOR2 complex	ok_for_propagation_to_go	GO:0061700	GATOR2 complex	WDR59		already_in_goa_exact	GO:0061700 GATOR2 complex	This PN type identifies ubiquitin/UBL-binding factors assigned to the GATOR2 complex. The GO cellular-component term GATOR2 complex is an appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3
BABAM2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRCA1-A complex component|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	BRCA1-A complex component	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0006302 double-strand break repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
ABRAXAS1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRCA1-A complex component|idiosyncratic Ub binding / MPN	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	BRCA1-A complex component	idiosyncratic Ub binding / MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0006302 double-strand break repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
ABRAXAS2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component|idiosyncratic Ub binding / MPN	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	BRISC complex component	idiosyncratic Ub binding / MPN	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		new_to_goa		This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
GCNA		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA protein crosslink recognition|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA protein crosslink recognition	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0106300 protein-DNA covalent cross-linking repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
POLH		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase|UBZ3-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA polymerase	UBZ3-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
POLK		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase|UBZ4-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA polymerase	UBZ4-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
POLI		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase|UBM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA polymerase	UBM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
REV1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|dCTP transferase|UBM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	dCTP transferase	UBM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
ERCC5		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA endonuclease|UBM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA endonuclease	UBM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0000724 double-strand break repair via homologous recombination;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation;GO:0006289 nucleotide-excision repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
SLX4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA endonuclease cofactor|UIM, UBZ4-type ZnF, SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA endonuclease cofactor	UIM, UBZ4-type ZnF, SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
DCLRE1A		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA exonuclease|UBZ4-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA exonuclease	UBZ4-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
FAN1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA exonuclease|UBZ4-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA exonuclease	UBZ4-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
FAAP20		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory|UBZ2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA repair accessory	UBZ2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0036297 interstrand cross-link repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
XRCC4		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA repair accessory	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0006284 base-excision repair;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
TP53BP1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA repair accessory	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0006303 double-strand break repair via nonhomologous end joining;GO:0097680 double-strand break repair via classical nonhomologous end joining	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
NEIL3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA glycosylase|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA glycosylase	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
TDG		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA glycosylase|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA glycosylase	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0006284 base-excision repair;GO:0006285 base-excision repair, AP site formation;GO:0045008 depyrimidination	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
ERCC6L		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA helicase|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA helicase	SIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
ERCC6		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA helicase|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA helicase	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
TDP2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|5'-tyrosyl DNA phosphodiesterase|UBA-like (TDP2)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	5'-tyrosyl DNA phosphodiesterase	UBA-like (TDP2)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:0006302 double-strand break repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
UBAP2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	RNA polymerase II removal	UBA (UBAP2)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		new_to_goa		This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
UBAP2L		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	RNA polymerase II removal	UBA (UBAP2)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		new_to_goa		This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
ATRIP		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA damage signalling|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA damage signalling	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
XPA		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|binding to damaged DNA|UBZ (XPA)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	binding to damaged DNA	UBZ (XPA)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
FANCD2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|binding to damaged DNA|idiosyncratic Ub binding / alpha solenoid	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	binding to damaged DNA	idiosyncratic Ub binding / alpha solenoid	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
RAD51AP1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA binding|UIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	DNA binding	UIM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		already_in_goa_exact	GO:0006281 DNA repair	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
NIPBL		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|cohesin loading|UBM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA repair	cohesin loading	UBM	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	ok_for_propagation_to_go	GO:0006281	DNA repair	BABAM2;ABRAXAS1;ABRAXAS2;GCNA;POLH		entailed_by_goa_closure	GO:1990414 replication-born double-strand break repair via sister chromatid exchange	This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
RFC1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNA polymerase clamp loader|tandem MIU	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA replication	DNA polymerase clamp loader	tandem MIU	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication	ok_for_propagation_to_go	GO:0006260	DNA replication	RFC1;WRNIP1;ZRANB3		already_in_goa_exact	GO:0006260 DNA replication	This PN group is defined by ubiquitin/UBL-binding roles in DNA replication. The source category is narrower than the GO process itself and is therefore treated as a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms3
WRNIP1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNA polymerase accessory|UBZ4-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA replication	DNA polymerase accessory	UBZ4-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication	ok_for_propagation_to_go	GO:0006260	DNA replication	RFC1;WRNIP1;ZRANB3		already_in_goa_exact	GO:0006260 DNA replication	This PN group is defined by ubiquitin/UBL-binding roles in DNA replication. The source category is narrower than the GO process itself and is therefore treated as a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms3
ZRANB3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNE endonuclease and helicase|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	DNA replication	DNE endonuclease and helicase	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication	ok_for_propagation_to_go	GO:0006260	DNA replication	RFC1;WRNIP1;ZRANB3		entailed_by_goa_closure	GO:0031297 replication fork processing;GO:0071932 replication fork reversal	This PN group is defined by ubiquitin/UBL-binding roles in DNA replication. The source category is narrower than the GO process itself and is therefore treated as a propagation mapping.		proteostasis-workbook-2024; proteostasis-ms3
SMARCAD1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|CUE	Ubiquitin Proteasome System	Ubiquitin and UBL binding	other DNA dependent processes	chromatin remodeling	CUE	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling	ok_for_propagation_to_go	GO:0006338	chromatin remodeling	SMARCAD1;CHD3;RSF1		already_in_goa_exact	GO:0006338 chromatin remodeling	This PN type groups ubiquitin/UBL-binding factors assigned to chromatin remodeling. The source is a context bucket rather than a canonical GO class, so propagation scope is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
CHD3		Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	other DNA dependent processes	chromatin remodeling	SIM	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling	ok_for_propagation_to_go	GO:0006338	chromatin remodeling	SMARCAD1;CHD3;RSF1		already_in_goa_exact	GO:0006338 chromatin remodeling	This PN type groups ubiquitin/UBL-binding factors assigned to chromatin remodeling. The source is a context bucket rather than a canonical GO class, so propagation scope is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
RSF1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	other DNA dependent processes	chromatin remodeling	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling	ok_for_propagation_to_go	GO:0006338	chromatin remodeling	SMARCAD1;CHD3;RSF1		already_in_goa_exact	GO:0006338 chromatin remodeling	This PN type groups ubiquitin/UBL-binding factors assigned to chromatin remodeling. The source is a context bucket rather than a canonical GO class, so propagation scope is appropriate.		proteostasis-workbook-2024; proteostasis-ms3
RSF1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	other DNA dependent processes	chromatin remodeling	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	subtype	Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|idiosyncratic Ub binding / other	ok_for_propagation_to_go	GO:0006338	chromatin remodeling	RSF1		already_in_goa_exact	GO:0006338 chromatin remodeling	In `4.3.11`, the residual chromatin-remodeling subgroup is labeled idiosyncratic Ub binding / other rather than just idiosyncratic. The parent chromatin-remodeling GO term remains the safest propagation target.		proteostasis-workbook-2024; proteostasis-ms3
DMRTA1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|DNA binding|CUE (DMA)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	transcription	DNA binding	CUE (DMA)	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|DNA binding	ok_for_propagation_to_go	GO:0003677	DNA binding	DMRTA1;DMRTA2		entailed_by_goa_closure	GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding	This PN type groups ubiquitin/UBL-binding factors assigned to transcriptional DNA-binding contexts. Propagation to GO DNA binding is appropriate, with the caveat that the PN source is context-defined.		proteostasis-workbook-2024; proteostasis-ms3
DMRTA2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|DNA binding|CUE (DMA)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	transcription	DNA binding	CUE (DMA)	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|DNA binding	ok_for_propagation_to_go	GO:0003677	DNA binding	DMRTA1;DMRTA2		entailed_by_goa_closure	GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding	This PN type groups ubiquitin/UBL-binding factors assigned to transcriptional DNA-binding contexts. Propagation to GO DNA binding is appropriate, with the caveat that the PN source is context-defined.		proteostasis-workbook-2024; proteostasis-ms3
RBM44		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|UBA-like (other)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	UBA-like (other)	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
RBM5		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		entailed_by_goa_closure	GO:0000381 regulation of alternative mRNA splicing, via spliceosome	This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
RBM6		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
RBM10		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
ZRANB2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
PRPF8		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|idiosyncratic Ub binding / MPN	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	idiosyncratic Ub binding / MPN	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		entailed_by_goa_closure	GO:0048025 negative regulation of mRNA splicing, via spliceosome	This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
DHX16		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|idiosyncratic Ub binding / other	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	idiosyncratic Ub binding / other	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
SMN1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	SIM	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
SMN2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA maturation	mRNA splicing	SIM	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	ok_for_propagation_to_go	GO:0048024	regulation of mRNA splicing, via spliceosome	RBM44;RBM5;RBM6;RBM10;ZRANB2		new_to_goa		This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache.		proteostasis-workbook-2024; proteostasis-ms3
NXF1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export|mRNA export|UBA-like (TAC)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA export	mRNA export	UBA-like (TAC)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export	ok_for_propagation_to_go	GO:0016973	poly(A)+ mRNA export from nucleus	NXF1;NXF2;NXF2B		already_in_goa_exact	GO:0016973 poly(A)+ mRNA export from nucleus	This PN group is a direct mRNA-export context bucket within the UPS branch. The GO mRNA export term is the specific target supported by the local ontology cache.		proteostasis-workbook-2024; proteostasis-ms3
NXF2		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export|mRNA export|UBA-like (TAC)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA export	mRNA export	UBA-like (TAC)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export	ok_for_propagation_to_go	GO:0016973	poly(A)+ mRNA export from nucleus	NXF1;NXF2;NXF2B		already_in_goa_exact	GO:0016973 poly(A)+ mRNA export from nucleus	This PN group is a direct mRNA-export context bucket within the UPS branch. The GO mRNA export term is the specific target supported by the local ontology cache.		proteostasis-workbook-2024; proteostasis-ms3
NXF2B		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export|mRNA export|UBA-like (TAC)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mRNA export	mRNA export	UBA-like (TAC)	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export	ok_for_propagation_to_go	GO:0016973	poly(A)+ mRNA export from nucleus	NXF1;NXF2;NXF2B		already_in_goa_exact	GO:0016973 poly(A)+ mRNA export from nucleus	This PN group is a direct mRNA-export context bucket within the UPS branch. The GO mRNA export term is the specific target supported by the local ontology cache.		proteostasis-workbook-2024; proteostasis-ms3
NUP153		Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|mRNA, protein export|RanBP2-type ZnF	Ubiquitin Proteasome System	Ubiquitin and UBL binding	nuclear pore complex subunit	mRNA, protein export	RanBP2-type ZnF	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit	ok_for_propagation_to_go	GO:0005643	nuclear pore	NUP153;SEC13;SEH1L		already_in_goa_exact	GO:0005643 nuclear pore	This PN group captures ubiquitin/UBL-binding nuclear pore complex subunits. The matching GO cellular-component term is nuclear pore.		proteostasis-workbook-2026; proteostasis-ms3
SEC13		Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|GATOR2 complex|SUMO binding / WD40	Ubiquitin Proteasome System	Ubiquitin and UBL binding	nuclear pore complex subunit	GATOR2 complex	SUMO binding / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit	ok_for_propagation_to_go	GO:0005643	nuclear pore	NUP153;SEC13;SEH1L		already_in_goa_exact	GO:0005643 nuclear pore	This PN group captures ubiquitin/UBL-binding nuclear pore complex subunits. The matching GO cellular-component term is nuclear pore.		proteostasis-workbook-2026; proteostasis-ms3
SEH1L		Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|GATOR2 complex|SUMO binding / WD40	Ubiquitin Proteasome System	Ubiquitin and UBL binding	nuclear pore complex subunit	GATOR2 complex	SUMO binding / WD40	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit	ok_for_propagation_to_go	GO:0005643	nuclear pore	NUP153;SEC13;SEH1L		already_in_goa_exact	GO:0005643 nuclear pore	This PN group captures ubiquitin/UBL-binding nuclear pore complex subunits. The matching GO cellular-component term is nuclear pore.		proteostasis-workbook-2026; proteostasis-ms3
EEA1		Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|phospholipid binding|UBZ (C2H2)	Ubiquitin Proteasome System	Ubiquitin and UBL binding	trafficking	phospholipid binding	UBZ (C2H2)	ubiquitin_proteasome_system.yaml	type	Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|phospholipid binding	ok_for_propagation_to_go	GO:0005543	phospholipid binding	EEA1		entailed_by_goa_closure	GO:0005545 1-phosphatidylinositol binding	This PN type denotes ubiquitin/UBL-binding factors additionally assigned to phospholipid binding in trafficking contexts. The matching GO molecular function is a reasonable propagation target.		proteostasis-workbook-2024; proteostasis-ms3
CEP55		Ubiquitin Proteasome System|Ubiquitin and UBL binding|mitotic exit and cytokinesis|mitotic exit and cytokinesis|UBAN-like, UBZ-like	Ubiquitin Proteasome System	Ubiquitin and UBL binding	mitotic exit and cytokinesis	mitotic exit and cytokinesis	UBAN-like, UBZ-like	ubiquitin_proteasome_system.yaml	group	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mitotic exit and cytokinesis	ok_for_propagation_to_go	GO:0000281	mitotic cytokinesis	CEP55		already_in_goa_exact	GO:0000281 mitotic cytokinesis	This PN group is a direct mitotic-exit/cytokinesis context bucket within the UPS branch. The GO mitotic cytokinesis process is the appropriate propagation target.		proteostasis-workbook-2024; proteostasis-ms3