gene_symbol	gene_name	target_go_id	target_go_label	goa_status	mapping_scopes	mapping_files	mapping_subjects	pn_codes	representative_genes	supporting_goa_terms	projection_count
AAAS		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
AATF		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	BOP1;DDX27;PELP1;PES1;WDR12		1
ABCE1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ABCF2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ABRAXAS1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
ABRAXAS2		GO:0006281	DNA repair	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component|idiosyncratic Ub binding / MPN	ABRAXAS1;ABRAXAS2;BABAM2;GCNA;POLH		1
ABTB1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
ABTB2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
ABTB3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin, transmembrane	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
ADRB2		GO:0061724	lipophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Upstream lipophagy signaling	ADRB2;AUP1;RAB7A;RAB7B;UBE2G2	GO:1904504 positive regulation of lipophagy	1
ADRM1		GO:0008540	proteasome regulatory particle, base subcomplex	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|PRU, DEUBAD	ADRM1;PSMD1;PSMD2;PSMD4	GO:0000502 proteasome complex	1
AFG3L2		GO:0005759	mitochondrial matrix	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	AFG3L2;CLPX;PITRM1;SPG7;YME1L1	GO:0005739 mitochondrion	1
AFG3L2		GO:0035694	mitochondrial protein catabolic process	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ANKZF1;FAF2;MARCHF5;USP30;VCP	GO:0030163 protein catabolic process	1
AGK		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7		1
AGR2		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
AGR3		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
AHCTF1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
AHR		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS	AHR;ARNT;COP1;DCAF13;DCAF7		1
AIP		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
AIPL1		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
AIRE		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other	PRPF19;STUB1;UBE4A;UBOX5;WDSUB1		1
AKIRIN1		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		1
AKIRIN2		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		1
AKT1		GO:1904715	negative regulation of chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Modulator of LAMP2A multimerization	AKT1;CTSA;RICTOR	GO:0010507 negative regulation of autophagy	1
AMBRA1		GO:1904716	positive regulation of chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Enhancer of substrate uptake	AMBRA1;GFAP;MT-RNR2;PSME1;TP53	GO:0010508 positive regulation of autophagy	1
ANAPC2		GO:0160072	ubiquitin ligase complex scaffold activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, APC sununit	CUL1;CUL2;CUL3;CUL4A;CUL4B		1
ANKFY1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
ANKZF1		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Vms pathway	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
ARF1		GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	COPA;COPB1;COPB2;COPE;COPG1	GO:0016192 vesicle-mediated transport	1
ARF1		GO:0030126	COPI vesicle coat	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ARF1;GBF1	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0032991 protein-containing complex	1
ARL8A		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4		3
ARL8B		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4		3
ARNT		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS	AHR;ARNT;COP1;DCAF13;DCAF7		1
ASCC1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ASCC1		GO:0072344	rescue of stalled cytosolic ribosome	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ASCC2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ASCC3		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ATAD1		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|mitoCPR pathway	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
ATAD3A		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
ATF3		GO:0140467	integrated stress response signaling	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor|Integrated stress response;PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes	ATF3;ATF4;DDIT3		2
ATG14		GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Class 3 PI3K complex 1 component	ATG14;BECN1;BECN2;PIK3C3;PIK3R4	GO:0032991 protein-containing complex;GO:0035032 phosphatidylinositol 3-kinase complex, class III	1
ATG2A		GO:0062079	ATG2-ATG18 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ATG2A;ATG2B;WDR45B;WIPI1;WIPI2	GO:0000407 phagophore assembly site;GO:0034045 phagophore assembly site membrane	1
ATG2B		GO:0062079	ATG2-ATG18 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ATG2A;ATG2B;WDR45B;WIPI1;WIPI2	GO:0000407 phagophore assembly site;GO:0034045 phagophore assembly site membrane	1
ATL3		GO:0061709	reticulophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	RETREG1;RETREG2;RETREG3;RTN3;SEC62		1
ATP13A1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Removal of misinserted transmembrane proteins	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
ATP23		GO:0005758	mitochondrial intermembrane space	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	ATP23;HTRA2;NLN	GO:0005739 mitochondrion	1
ATP23		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
ATP6AP1		GO:0060590	ATPase regulator activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	ATP6AP1;ATP6AP2;LRRK2		2
ATP6AP2		GO:0060590	ATPase regulator activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump	ATP6AP1;ATP6AP2;LRRK2		2
ATP6V0A1		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V0A2		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0007035 vacuolar acidification	1
ATP6V0A2		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V0A4		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0006885 regulation of pH;GO:0007035 vacuolar acidification;GO:0051452 intracellular pH reduction	1
ATP6V0A4		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V0B		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033176 proton-transporting V-type ATPase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V0C		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033176 proton-transporting V-type ATPase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain;GO:0033179 proton-transporting V-type ATPase, V0 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex;GO:0098588 bounding membrane of organelle	1
ATP6V0D1		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0007035 vacuolar acidification;GO:0042592 homeostatic process	1
ATP6V0D1		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0032991 protein-containing complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	1
ATP6V0D2		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0007035 vacuolar acidification	1
ATP6V0D2		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V0E1		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0007035 vacuolar acidification	1
ATP6V0E1		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V0E2		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0007035 vacuolar acidification	1
ATP6V0E2		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
ATP6V1A		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0016020 membrane;GO:0016469 proton-transporting two-sector ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	1
ATP6V1B1		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0006885 regulation of pH;GO:0007035 vacuolar acidification	1
ATP6V1B1		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	1
ATP6V1B2		GO:0007042	lysosomal lumen acidification	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0007035 vacuolar acidification	1
ATP6V1B2		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0033180 proton-transporting V-type ATPase, V1 domain	1
ATP6V1C1		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1C1		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016469 proton-transporting two-sector ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	1
ATP6V1C2		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1C2		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0033180 proton-transporting V-type ATPase, V1 domain	1
ATP6V1D		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0033176 proton-transporting V-type ATPase complex;GO:0046611 lysosomal proton-transporting V-type ATPase complex	1
ATP6V1E1		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1E1		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0016469 proton-transporting two-sector ATPase complex;GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain;GO:0046611 lysosomal proton-transporting V-type ATPase complex	1
ATP6V1E2		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1E2		GO:0033176	proton-transporting V-type ATPase complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2		1
ATP6V1E2		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0005774 vacuolar membrane;GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain	1
ATP6V1F		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	1
ATP6V1G1		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1G1		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033176 proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain	1
ATP6V1G2		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1G2		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex	1
ATP6V1G3		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
ATP6V1G3		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0016471 vacuolar proton-transporting V-type ATPase complex	1
ATP6V1H		GO:0046612	lysosomal proton-transporting V-type ATPase, V1 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V1 lysosomal v-ATPase proton pump component	ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2	GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0005765 lysosomal membrane;GO:0016020 membrane	1
ATRX		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
AUP1		GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|CUE	AUP1;UFD1	GO:0036503 ERAD pathway	1
AZI2		GO:0098792	xenophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy	AZI2;LGALS8		1
BABAM1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|other / RCC1, SPRY, WD40	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
BAG2		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|BAG	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		1
BAG3		GO:0035973	aggrephagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	BAG3;HSPA8;HSPB8;STUB1	GO:1905337 positive regulation of aggrephagy	1
BAZ1B		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|kinase, bromodomain	MID1;MID2;TRIM36;TRIM46;TRIM9		1
BCAP31		GO:0036503	ERAD pathway	more_specific_than_existing_goa	exact	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	DERL1;DERL2;DERL3;HERPUD1;SYVN1	GO:0034976 response to endoplasmic reticulum stress	1
BCCIP		GO:0000027	ribosomal large subunit assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	BCCIP;RSL24D1		1
BCCIP		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	AATF;IMP3;NOP56;UTP4		1
BCL2L13		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1		1
BIRC6		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2|BIR repeat	BIRC6;UBE2O	GO:0004842 ubiquitin-protein transferase activity	1
BMAL1		GO:1904715	negative regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Negative regulator of transcription of CMA components	BMAL1;RAB11A;RARA		1
BMI1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9		2
BNIP1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	BNIP1;MARCHF5;RNF185;TANK;TBK1		1
BNIP3L		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1	GO:1901524 regulation of mitophagy	1
BRIP1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|DNA helicase	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
BRWD1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
BRWD3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
BTBD1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD10		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD16		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD17		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD6		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD7		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD8		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BTBD9		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
BUD23		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
BZW1		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
BZW1		GO:0006413	translational initiation	supported_by_goa_regulation	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B	GO:0006446 regulation of translational initiation	1
BZW2		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
BZW2		GO:0006413	translational initiation	supported_by_goa_regulation	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B	GO:0006446 regulation of translational initiation	1
CABIN1		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
CACUL1		GO:0160072	ubiquitin ligase complex scaffold activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, possible CUL3 inhibitor	CUL1;CUL2;CUL3;CUL4A;CUL4B		1
CACYBP		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
CALCOCO1		GO:0061709	reticulophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	RETREG1;RETREG2;RETREG3;RTN3;SEC62		1
CALCOCO2		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;RABGEF1;SQSTM1;TAX1BP1		2
CALCOCO2		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1		2
CALCOCO2		GO:0160247	autophagy cargo adaptor activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	CALCOCO2;TRIM16		1
CALM1		GO:0000151	ubiquitin ligase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|noncatalytic subunit	CALM1;KCMF1;UBR4	GO:0032991 protein-containing complex;GO:1902494 catalytic complex	1
CALR		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
CALR3		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
CAMLG		GO:0003755	peptidyl-prolyl cis-trans isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	CAMLG;FKBP2;FKBP7;PPIB;PPIC		2
CAMLG		GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|GET pathway component	ER proteostasis|Protein transport|GET pathway component	CAMLG;GET1;GET3;GET4;SGTA		1
CAMLG		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
CAND1		GO:1990757	ubiquitin ligase activator activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor;Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	CAND1;CAND2		2
CAND2		GO:1990757	ubiquitin ligase activator activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor;Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like	CAND1;CAND2		2
CANX		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
CASQ1		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
CASQ2		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
CCDC47		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
CCDC47		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
CCDC47		GO:0160005	PAT complex	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	CCDC47;WDR83OS	GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane	1
CCDC50		GO:0160247	autophagy cargo adaptor activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	CCDC50;MEFV		1
CDC37L1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding;GO:0031072 heat shock protein binding	1
CDK5RAP3		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
CDK5RAP3		GO:0061709	reticulophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	RETREG1;RETREG2;RETREG3;RTN3;SEC62	GO:0140501 positive regulation of reticulophagy	1
CGRRF1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
CHAF1A		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
CHAF1B		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
CHCHD4		GO:0061617	MICOS complex	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	Mitochondrial proteostasis|Membrane protein folding|MICOS complex	APOO;CHCHD3;CHCHD6;IMMT;MICOS13	GO:0005739 mitochondrion	1
CHIC2		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex|noncatalytic	CHIC2;STUB1		1
CHMP1A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy	1
CHMP1B		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy	1
CHMP2A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP2B		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP3		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP4A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP4B		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP4C		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP5		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy	1
CHMP6		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
CHMP7		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy	1
CLCN7		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
CLGN		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
CLPX		GO:0035694	mitochondrial protein catabolic process	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ANKZF1;FAF2;MARCHF5;USP30;VCP	GO:0030163 protein catabolic process	1
CMYA5		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & FN & SPRY	MID1;MID2;TRIM36;TRIM46;TRIM9		1
CNOT4		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
CNPY3		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|Folding of TLRs	CNPY3;MZB1	GO:0005515 protein binding	1
COLGALT1		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
COLGALT2		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
COP1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other	AHR;ARNT;COP1;DCAF13;DCAF7		1
COPE		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
CRBN		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|LON, Yippee, DOC	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
CRTAP		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
CRYAA		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		1
CRYAB		GO:0044183	protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml;mitochondrial_proteostasis.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8	GO:0006457 protein folding	2
CSNK1D		GO:0000045	autophagosome assembly	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Specific function in sealing of autophagophore membrane unknown	TSG101;VPS28;VPS37A;VPS37B;VPS37C		1
CSNK2B		GO:0032040	small-subunit processome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	HEATR1;UTP15;UTP4;WDR43;WDR75	GO:0005634 nucleus	1
CSNK2B		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	AATF;IMP3;NOP56;UTP4		1
CWC27		GO:0003755	peptidyl-prolyl cis-trans isomerase activity	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C		2
CYB5R4		GO:0051879	Hsp90 protein binding	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6		1
DCAF10		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF11		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF12L1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF12L2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF15		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF16		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF17		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF4		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF4L1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF4L2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF5		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF6		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|IQ motif	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF7		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other	AHR;ARNT;COP1;DCAF13;DCAF7	GO:0030674 protein-macromolecule adaptor activity	1
DCAF8		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF8L1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DCAF8L2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DDA1		GO:0160072	ubiquitin ligase complex scaffold activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold|(no type)|(no subtype)	DDA1		1
DDB1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor|DDB1	DDB1;SKP1	GO:0030674 protein-macromolecule adaptor activity	1
DDB2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
DDRGK1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
DDX19B		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
DDX21		GO:0032040	small-subunit processome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	HEATR1;UTP15;UTP4;WDR43;WDR75	GO:0005730 nucleolus	1
DDX21		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	AATF;IMP3;NOP56;UTP4		1
DDX27		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex	BOP1;DDX27;PELP1;PES1;WDR12		1
DDX3X		GO:0003743	translation initiation factor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H	GO:0006413 translational initiation	1
DDX3Y		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
DDX3Y		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
DELE1		GO:0006417	regulation of translation	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator	PN regulation|Translation regulator|Integrated stress response|EIF2AK1 modulator	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		1
DENR		GO:0006415	translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|tRNA, mRNA release	ABCE1;EIF2D;ETF1;GSPT1;GSPT2		1
DEPTOR		GO:0031931	TORC1 complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	AKT1S1;DEPTOR;MLST8;MTOR;RPTOR		1
DEPTOR		GO:0031932	TORC2 complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	DEPTOR;MAPKAP1;MLST8;MTOR;RICTOR		1
DHX15		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	BOP1;DDX27;PELP1;PES1;WDR12		1
DHX15		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	AATF;IMP3;NOP56;UTP4		1
DHX16		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|idiosyncratic Ub binding / other	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
DHX29		GO:0003743	translation initiation factor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H	GO:0006413 translational initiation	1
DNAAF11		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
DNAAF4		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and CS domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
DNAAF6		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
DNAJB1		GO:0061684	chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8		1
DNAJB1		GO:0061738	late endosomal microautophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	DNAJB1;HSPA8;STIP1		1
DNAJB1		GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	new_to_goa	exact	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery	CLU;DNAJB1;HSPA8		1
DNAJB11		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJB13		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	1
DNAJB4		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	1
DNAJB5		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	1
DNAJC1		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	1
DNAJC10		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
DNAJC11		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC12		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC13		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC14		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC15		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC16		GO:0030544	Hsp70 protein binding	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB		1
DNAJC17		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC19		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC21		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC21		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
DNAJC21		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	AATF;IMP3;NOP56;UTP4		1
DNAJC22		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC24		GO:0030544	Hsp70 protein binding	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB		1
DNAJC25		GO:0030544	Hsp70 protein binding	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB		1
DNAJC27		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC28		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC3		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0051087 protein-folding chaperone binding	1
DNAJC30		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC4		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC5		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC5B		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
DNAJC5G		GO:0030544	Hsp70 protein binding	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB		1
DNAJC6		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0031072 heat shock protein binding	1
DNAJC7		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0031072 heat shock protein binding	1
DNAJC9		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding;GO:0031072 heat shock protein binding;GO:0051087 protein-folding chaperone binding	1
DNM1L		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901524 regulation of mitophagy	1
DRG2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
DTL		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP	GO:0030674 protein-macromolecule adaptor activity	1
DUSP12		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
DUSP12		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	AATF;IMP3;NOP56;UTP4		1
ECT2L		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
EDEM1		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	DAD1;DDOST;MAGT1;OSTC;RPN1		1
EDEM2		GO:0006487	protein N-linked glycosylation	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	DAD1;DDOST;MAGT1;OSTC;RPN1	GO:0009100 glycoprotein metabolic process	1
EDEM2		GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	EDEM1;EDEM2;EDEM3;MAN1B1	GO:0009100 glycoprotein metabolic process;GO:0036503 ERAD pathway;GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway	1
EDEM3		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	DAD1;DDOST;MAGT1;OSTC;RPN1		1
EDF1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
EEF1A1		GO:1904716	positive regulation of chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	AMBRA1;GFAP;MT-RNR2;PSME1;TP53	GO:1904714 regulation of chaperone-mediated autophagy	1
EEF1A2		GO:1904716	positive regulation of chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	AMBRA1;GFAP;MT-RNR2;PSME1;TP53	GO:1904714 regulation of chaperone-mediated autophagy	1
EEF1G		GO:0005853	eukaryotic translation elongation factor 1 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation elongation|EEF1B complex	Translation|Cytosolic translation|Translation elongation|EEF1B complex	EEF1B2;EEF1D;EEF1G	GO:0005737 cytoplasm	1
EEF2K		GO:0003746	translation elongation factor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT	GO:0006414 translational elongation	1
EEF2KMT		GO:0003746	translation elongation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		1
EFL1		GO:0030687	preribosome, large subunit precursor	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12	GO:1990904 ribonucleoprotein complex	1
EIF2AK1		GO:0032055	negative regulation of translation in response to stress	more_specific_than_existing_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4	GO:0006417 regulation of translation;GO:0006950 response to stress	1
EIF2AK2		GO:0032055	negative regulation of translation in response to stress	more_specific_than_existing_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4	GO:0017148 negative regulation of translation	1
EIF2AK2		GO:0140467	integrated stress response signaling	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A		1
EIF2AK3		GO:1903894	regulation of IRE1-mediated unfolded protein response	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Unfolded protein response;PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1	EIF2AK3		2
EIF2AK4		GO:0032055	negative regulation of translation in response to stress	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4		1
EIF2D		GO:0006415	translational termination	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|tRNA, mRNA release	ABCE1;EIF2D;ETF1;GSPT1;GSPT2	GO:0043933 protein-containing complex organization	1
EIF3J		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
EIF4E2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
EIF4EBP1		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
EIF4EBP1		GO:0006413	translational initiation	supported_by_goa_regulation	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B	GO:0045947 negative regulation of translational initiation	1
EIF4EBP2		GO:0003743	translation initiation factor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H	GO:0006412 translation	1
EIF4EBP2		GO:0006413	translational initiation	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B	GO:0006412 translation	1
EIF4EBP3		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
EIF4EBP3		GO:0006413	translational initiation	supported_by_goa_regulation	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B	GO:0045947 negative regulation of translational initiation	1
EIF5A		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
EIF5B		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
EIF6		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
ELAC2		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|RNAse Z	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
ELOA		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
EMC1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC1		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC10		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC10		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC2		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC2		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC3		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC3		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC4		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC4		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC6		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC6		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC7		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC7		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC8		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC8		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
EMC9		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
EMC9		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
ENGASE		GO:0006517	protein deglycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ENGASE;MAN2C1;NGLY1		1
ENGASE		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
ERLIN1		GO:0000151	ubiquitin ligase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7	GID8;MAEA;RANBP10;RMND5A;RMND5B	GO:0032991 protein-containing complex	1
ERLIN2		GO:0000151	ubiquitin ligase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7	GID8;MAEA;RANBP10;RMND5A;RMND5B	GO:0032991 protein-containing complex	1
ERN1		GO:1903894	regulation of IRE1-mediated unfolded protein response	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator	PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator	ERN1		1
ERO1A		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases;ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	AGR2;AGR3;CASQ1;CASQ2;DNAJC10;ERO1A;ERO1B		2
ERO1B		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases;ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation	AGR2;AGR3;CASQ1;CASQ2;DNAJC10;ERO1A;ERO1B		2
ERP27		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
ERP29		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
FAF2		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
FAM72A		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCA		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCB		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCC		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCE		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCF		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCG		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / TPR	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
FANCL		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|catalytic / RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|FANC / catalytic subunit|idiosyncratic Ub binding / ELF	ANAPC11;ANAPC2;FANCL;GID8;KCMF1;MAEA;RANBP10;RMND5A;RMND5B;SHARPIN		2
FBH1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|DNA helicase	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL12		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL13		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL14		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL15		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL16		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL17		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL18		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL20		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL21P		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL22		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL5		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL6		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL7		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXL8		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO10		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO15		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO16		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO17		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO21		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO22		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO25		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO27		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO30		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO33		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO34		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO36		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO39		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO40		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO41		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO43		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO47		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO5		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO6		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXO7		GO:0000423	mitophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy|PINK/PRKN pathway	FBXO7;VPS13D	GO:0000422 autophagy of mitochondrion	1
FBXO8		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXW10		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXW10B		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2	GO:0003674 molecular_function	1
FBXW12		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXW2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXW4		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40	ASB2;FBXW4;FBXW7;FBXW8;PML		1
FBXW4		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXW5		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FBXW7		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40	ASB2;FBXW4;FBXW7;FBXW8;PML		1
FBXW8		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40	ASB2;FBXW4;FBXW7;FBXW8;PML		1
FBXW9		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
FKBP4		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding;GO:0031072 heat shock protein binding	1
FKBP5		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding;GO:0031072 heat shock protein binding	1
FKBP6		GO:0003755	peptidyl-prolyl cis-trans isomerase activity	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type	AIP;AIPL1;FKBP1A;FKBP1B;FKBP3		2
FKBP8		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1	GO:1901524 regulation of mitophagy	1
FKBP8		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
FKBPL		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
FNIP1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
FNIP2		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
FOSB		GO:0035976	transcription factor AP-1 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	FOS;FOSB;FOSL1;FOSL2;JUN	GO:0005634 nucleus	1
FOSL1		GO:0035976	transcription factor AP-1 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	Autophagy-Lysosome Pathway|Autophagy gene expression|AP-1 transcriptional program|Component of AP-1 transcription factor	FOS;FOSB;FOSL1;FOSL2;JUN	GO:0005634 nucleus	1
FYCO1		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3		2
GABARAP		GO:0061739	protein lipidation involved in autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	GABARAP;GABARAPL1;MAP1LC3B	GO:0000045 autophagosome assembly	1
GABARAPL1		GO:0061739	protein lipidation involved in autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	GABARAP;GABARAPL1;MAP1LC3B	GO:0000045 autophagosome assembly	1
GAK		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
GBF1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
GBF1		GO:0030126	COPI vesicle coat	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating	ARF1;GBF1	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane	1
GCN1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes;Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		2
GCN1		GO:0016567	protein ubiquitination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	GCN1;RNF14;RNF25		1
GET1		GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|GET pathway component	ER proteostasis|Protein transport|GET pathway component	CAMLG;GET1;GET3;GET4;SGTA	GO:0090150 establishment of protein localization to membrane	1
GET1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
GET3		GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|GET pathway component	ER proteostasis|Protein transport|GET pathway component	CAMLG;GET1;GET3;GET4;SGTA		1
GET3		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
GET4		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
GFAP		GO:1904716	positive regulation of chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	AMBRA1;GFAP;MT-RNR2;PSME1;TP53	GO:1904714 regulation of chaperone-mediated autophagy	1
GIGYF1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
GIGYF2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
GLE1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
GLMN		GO:1904667	negative regulation of ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor	GLMN		1
GMCL1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
GMCL2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
GNL2		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
GNL2		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	AATF;IMP3;NOP56;UTP4		1
GORAB		GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	COPA;COPB1;COPB2;COPE;COPG1		1
GORAB		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
GORAB		GO:0030126	COPI vesicle coat	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	GORAB;SCYL1;SCYL3	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus	1
GTPBP1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
GTPBP1		GO:0072344	rescue of stalled cytosolic ribosome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1	GO:0002181 cytoplasmic translation;GO:0006414 translational elongation	1
GTPBP2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
GTPBP2		GO:0072344	rescue of stalled cytosolic ribosome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1	GO:0006414 translational elongation	1
GTPBP4		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
GTPBP6		GO:0070126	mitochondrial translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Translation termination	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	MRPL58;MTRES1;MTRF1;MTRF1L;MTRFR		1
GTPBP6		GO:7770016	rescue of stalled mitochondrial ribosome	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	GTPBP6;MRPL58;MTRES1;MTRFR		1
GUF1		GO:0003746	translation elongation factor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	Translation|Mitochondrial translation|Translation elongation|assorted elongation factors	GFM1;GUF1;TSFM;TUFM	GO:0006412 translation	1
HACD3		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
HAP1		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	ARL8A;ARL8B;HAP1;HTT;MAP1LC3B;RILP;RUFY3		2
HAPSTR1		GO:0006950	response to stress	supported_by_goa_regulation	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Stress response integration	PN regulation|Stress response integration|Multi-stress response|Modulation of stress responses	HAPSTR1;HAPSTR2;HUWE1	GO:0080135 regulation of cellular response to stress	1
HAPSTR2		GO:0006950	response to stress	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Stress response integration	PN regulation|Stress response integration|Multi-stress response|Modulation of stress responses	HAPSTR1;HAPSTR2;HUWE1		1
HAT1		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
HBS1L		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
HEATR3		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
HERPUD2		GO:0036503	ERAD pathway	new_to_goa	exact	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex	DERL1;DERL2;DERL3;HERPUD1;SYVN1		1
HIRA		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
HJURP		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
HK2		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1905091 positive regulation of type 2 mitophagy	1
HOXB4		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
HSCB		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0003674 molecular_function;GO:0005515 protein binding;GO:0051087 protein-folding chaperone binding	1
HSD17B10		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
HSF2		GO:0034605	cellular response to heat	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor|Heat shock response;PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	HSF1;HSF2;HSF4;HSF5		2
HSF4		GO:0034605	cellular response to heat	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor|Heat shock response;PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	HSF1;HSF2;HSF4;HSF5		2
HSF5		GO:0034605	cellular response to heat	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor|Heat shock response;PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes	HSF1;HSF2;HSF4;HSF5		2
HSP90AA1		GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	HSP90AA1;HSP90AB1;ST13;STIP1;STUB1	GO:0061684 chaperone-mediated autophagy	1
HSP90AB1		GO:0061684	chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8		1
HSP90AB1		GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	HSP90AA1;HSP90AB1;ST13;STIP1;STUB1		1
HSPA13		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|HSP70	ER proteostasis|Chaperone|HSP70 system|HSP70	HSPA13;HSPA5	GO:0044183 protein folding chaperone	1
HSPA14		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6	GO:0006457 protein folding;GO:0044183 protein folding chaperone	1
HSPA1A		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6	GO:0044183 protein folding chaperone	1
HSPA1B		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6	GO:0044183 protein folding chaperone	1
HSPA1L		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6	GO:0044183 protein folding chaperone	1
HSPA2		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6	GO:0044183 protein folding chaperone	1
HSPA5		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|HSP70	ER proteostasis|Chaperone|HSP70 system|HSP70	HSPA13;HSPA5	GO:0044183 protein folding chaperone	1
HSPA6		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70	HSPA1A;HSPA1B;HSPA1L;HSPA2;HSPA6	GO:0044183 protein folding chaperone	1
HSPA8		GO:0035973	aggrephagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	BAG3;HSPA8;HSPB8;STUB1		1
HSPA8		GO:0061738	late endosomal microautophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	DNAJB1;HSPA8;STIP1		1
HSPA9		GO:0140662	ATP-dependent protein folding chaperone	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70	Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70	HSPA9	GO:0006457 protein folding;GO:0044183 protein folding chaperone	1
HSPB2		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml;mitochondrial_proteostasis.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8		2
HSPB3		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml;mitochondrial_proteostasis.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8		2
HSPB7		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		1
HSPB8		GO:0035973	aggrephagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	BAG3;HSPA8;HSPB8;STUB1	GO:1905337 positive regulation of aggrephagy	1
HSPB8		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml;mitochondrial_proteostasis.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP	CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8		2
HSPB9		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		1
HTT		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons	ARL8A;ARL8B;HAP1;HTT;MAP1LC3B;RILP;RUFY3		2
HUWE1		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Direct recruitment of AMBRA1	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1905091 positive regulation of type 2 mitophagy	1
HUWE1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
HYPK		GO:0006474	N-terminal protein amino acid acetylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|Modulator of NatA and NatE complexes	NAA10;NAA15;NAA20;NAA25;NAA30		1
IBTK		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin, RCC1	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
IFI27		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|transmembrane	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2	GO:0060090 molecular adaptor activity	1
IFI30		GO:0015035	protein-disulfide reductase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal thiol reductase	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal protein catabolism|Lysosomal thiol reductase	IFI30	GO:0016667 oxidoreductase activity, acting on a sulfur group of donors	1
ILF2		GO:0030687	preribosome, large subunit precursor	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	BOP1;DDX27;PELP1;PES1;WDR12	GO:1990904 ribonucleoprotein complex	1
ILF2		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	AATF;IMP3;NOP56;UTP4		1
ILF3		GO:0030687	preribosome, large subunit precursor	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	BOP1;DDX27;PELP1;PES1;WDR12	GO:1990904 ribonucleoprotein complex	1
ILF3		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex	AATF;IMP3;NOP56;UTP4		1
IMMP1L		GO:0017087	mitochondrial processing peptidase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0005739 mitochondrion	1
IMMP1L		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis;GO:0016485 protein processing	1
IMMP2L		GO:0017087	mitochondrial processing peptidase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0005739 mitochondrion	1
IMMP2L		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis;GO:0016485 protein processing	1
IMMT		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
ING4		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other	PRPF19;STUB1;UBE4A;UBOX5;WDSUB1		1
IPO4		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
IRF2BP2		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|IRF2 binding	MID1;MID2;TRIM36;TRIM46;TRIM9		1
ISG20L2		GO:0006364	rRNA processing	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	EXOSC10;FCF1;NOB1;PARN;RMRP	GO:0006396 RNA processing	1
ISG20L2		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	AATF;IMP3;NOP56;UTP4		1
ITGB1BP2		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
KAT2B		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|bromodomain, Acyl_CoA_acyltransferase	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91		1
KBTBD13		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KBTBD4		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCMF1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|noncatalytic subunit;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|idiosyncratic / noncatalytic|UBZ (Di19)	ANAPC11;ANAPC2;CALM1;FANCL;KCMF1;SHARPIN;UBR4		2
KCTD10		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD11		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD20		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD21		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD5		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD6		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD7		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KCTD9		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KDELR1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
KDELR2		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
KDELR3		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
KDM2A		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
KDM2B		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
KEAP1		GO:1900407	regulation of cellular response to oxidative stress	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor regulator|Oxidative stress response	PN regulation|Transcription factor regulator|Oxidative stress response|NFE2L2 modulator	KEAP1		1
KGD4		GO:0005761	mitochondrial ribosome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome;Translation|Mitochondrial translation|Ribosome|Mitoribosome	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion	2
KGD4		GO:0005763	mitochondrial small ribosomal subunit	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion	1
KLHL14		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KLHL31		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KLHL34		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KLHL42		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
KMT2A		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET	PRPF19;STUB1;UBE4A;UBOX5;WDSUB1		1
KMT2B		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET	PRPF19;STUB1;UBE4A;UBOX5;WDSUB1		1
KMT2C		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase	MID1;MID2;TRIM36;TRIM46;TRIM9		1
KMT2D		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase	MID1;MID2;TRIM36;TRIM46;TRIM9		1
LGALS3BP		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
LLPH		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
LLPH		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	AATF;IMP3;NOP56;UTP4		1
LMAN1		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
LMAN1L		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
LMAN2		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
LMAN2L		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
LMBR1L		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / transmembrane	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
LMNB1		GO:0044804	nucleophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Nucleophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Nucleophagy	LMNB1		1
LMO7		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|LIM, PDZ	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91	GO:0004842 ubiquitin-protein transferase activity	1
LNX2		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other	MID1;MID2;TRIM36;TRIM46;TRIM9	GO:0004842 ubiquitin-protein transferase activity	1
LONRF3		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
LRR1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	APPBP2;FEM1A;FEM1B;FEM1C;VHL		1
LRRC14		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	APPBP2;FEM1A;FEM1B;FEM1C;VHL		1
LRRC28		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|non-canonical|with LRR	APPBP2;FEM1A;FEM1B;FEM1C;VHL		1
LRRC42		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR	APPBP2;FEM1A;FEM1B;FEM1C;VHL		1
LRRK2		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
LRRK2		GO:0060590	ATPase regulator activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump	ATP6AP1;ATP6AP2;LRRK2		1
LRSAM1		GO:0098792	xenophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Intracellular pathogen ubiquitination	LRSAM1;PHF23;RNF166	GO:1904417 positive regulation of xenophagy	1
LSG1		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
LTN1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
MAGEA11		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|MAGE	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		1
MAN1B1		GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming	EDEM1;EDEM2;EDEM3;MAN1B1	GO:0009100 glycoprotein metabolic process;GO:0036503 ERAD pathway	1
MAN2C1		GO:0006517	protein deglycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ENGASE;MAN2C1;NGLY1		1
MAN2C1		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
MAP1LC3B		GO:0061739	protein lipidation involved in autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, direct|Preparation of ATG8 homologs for lipidation|ATG8 homolog	GABARAP;GABARAPL1;MAP1LC3B	GO:0000045 autophagosome assembly;GO:0006914 autophagy;GO:0016236 macroautophagy	1
MAP1LC3B		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3		3
MAP1S		GO:0000423	mitophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1	GO:0006914 autophagy	1
MAP1S		GO:0035973	aggrephagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	MAP1S;NBR1;OPTN;SQSTM1;TOLLIP	GO:0006914 autophagy	1
MAP3K20		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
MAP3K7		GO:0008385	IkappaB kinase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|AMPK signaling pathway, direct|AMPK complex modulator by phosphorylation|IKK complex component	CHUK;IKBKB;IKBKG;MAP3K7	GO:0005737 cytoplasm;GO:0005829 cytosol	1
MAPK8IP1		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3		2
MARCHF5		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	BNIP1;MARCHF5;RNF185;TANK;TBK1		1
MARCHF5		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
MARK2		GO:0000423	mitophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:0000422 autophagy of mitochondrion	1
MCM2		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
MCTS1		GO:0006415	translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|tRNA, mRNA release	ABCE1;EIF2D;ETF1;GSPT1;GSPT2		1
MDM4		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mdm|RanBP2-type ZNF;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Mdm|RanBP2-type ZnF	ASB2;FBXW4;FBXW7;FBXW8;MID1;MID2;PML;TRIM36;TRIM46;TRIM9		2
MEFV		GO:0160247	autophagy cargo adaptor activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates	CCDC50;MEFV		1
METAP1D		GO:0017087	mitochondrial processing peptidase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0005739 mitochondrion	1
METAP1D		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis	1
MEX3A		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	MID1;MID2;TRIM36;TRIM46;TRIM9		1
MEX3B		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	MID1;MID2;TRIM36;TRIM46;TRIM9		1
MEX3D		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3	MID1;MID2;TRIM36;TRIM46;TRIM9		1
MFN1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
MIDN		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		1
MIEF1		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Regulation of 28S-39S subunit association	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
MIPEP		GO:0017087	mitochondrial processing peptidase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix	1
MIPEP		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis;GO:0016485 protein processing	1
MKRN1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
MKRN2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
MLEC		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone	DAD1;DDOST;MAGT1;OSTC;RPN1		1
MMGT1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
MMGT1		GO:0044743	protein transmembrane import into intracellular organelle	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147	GO:0055085 transmembrane transport	1
MNAT1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / second enzymatic function|UIM	ASB2;FBXW4;FBXW7;FBXW8;MID1;MID2;PML;TRIM36;TRIM46;TRIM9		2
MRE11		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / DNA binding	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
MRM1		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
MRPS23		GO:0005761	mitochondrial ribosome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome;Translation|Mitochondrial translation|Ribosome|Mitoribosome	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion;GO:0005840 ribosome	2
MRPS23		GO:0005763	mitochondrial small ribosomal subunit	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion;GO:0005840 ribosome	1
MRPS25		GO:0005761	mitochondrial ribosome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome;Translation|Mitochondrial translation|Ribosome|Mitoribosome	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion	2
MRPS25		GO:0005763	mitochondrial small ribosomal subunit	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion	1
MRPS30		GO:0005763	mitochondrial small ribosomal subunit	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit	MRPS2;MRPS5;MRPS6;MRPS7;MRPS9	GO:0005739 mitochondrion;GO:0005840 ribosome	1
MSL1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|noncatalytic / other	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
MSL2		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|catalytic / RING	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
MT-RNR2		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Stabilizer of HSP90 binding of CMA substrates	AMBRA1;GFAP;MT-RNR2;PSME1;TP53		1
MTERF4		GO:0000154	rRNA modification	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B	GO:0006364 rRNA processing	1
MTMR14		GO:0046856	phosphatidylinositol dephosphorylation	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels	MTMR14;MTMR3;MTMR4;MTMR8;MTMR9		1
MTRES1		GO:0070126	mitochondrial translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Translation termination	Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes	MRPL58;MTRES1;MTRF1;MTRF1L;MTRFR		1
MUL1		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1905091 positive regulation of type 2 mitophagy	1
MVB12A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
MVB12B		GO:0000045	autophagosome assembly	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C		1
MYDGF		GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport;ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	COPA;COPB1;COPB2;COPE;COPG1;KDELR1;KDELR2;KDELR3;MYDGF		2
MYDGF		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
MYO6		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1		2
MZB1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|Folding of IGM and IgA	CNPY3;MZB1	GO:0005515 protein binding	1
N4BP1		GO:1990948	ubiquitin ligase inhibitor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor	Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor|ITCH inhibitor|UBA (N4BP1)	N4BP1		1
NAA10		GO:0006474	N-terminal protein amino acid acetylation	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component	NAA10;NAA15;NAA20;NAA25;NAA30	GO:0051604 protein maturation	1
NAA15		GO:0006474	N-terminal protein amino acid acetylation	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component	NAA10;NAA15;NAA20;NAA25;NAA30	GO:0051604 protein maturation	1
NAA25		GO:0006474	N-terminal protein amino acid acetylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatB complex component	NAA10;NAA15;NAA20;NAA25;NAA30		1
NAA30		GO:0006474	N-terminal protein amino acid acetylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component	NAA10;NAA15;NAA20;NAA25;NAA30		1
NAA35		GO:0006474	N-terminal protein amino acid acetylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component	NAA10;NAA15;NAA20;NAA25;NAA30		1
NAA38		GO:0006474	N-terminal protein amino acid acetylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component	NAA10;NAA15;NAA20;NAA25;NAA30		1
NAA40		GO:0006474	N-terminal protein amino acid acetylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide	Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatD, sole component	NAA10;NAA15;NAA20;NAA25;NAA30		1
NAP1L1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	BNIP1;MARCHF5;RNF185;TANK;TBK1		1
NAP1L2		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NAP1L3		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NAP1L4		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NAP1L5		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NASP		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
NASP		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NBN		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex /  BRCT	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
NBR1		GO:0000425	pexophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Pexophagy	NBR1;PJVK;SQSTM1	GO:0016236 macroautophagy	1
NBR1		GO:0035973	aggrephagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	MAP1S;NBR1;OPTN;SQSTM1;TOLLIP	GO:0016236 macroautophagy	1
NBR1		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	NBR1;SQSTM1;TRIM17	GO:0016236 macroautophagy	1
NCL		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NCLN		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
NCLN		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
NCOA4		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ferritinophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ferritinophagy	NCOA4	GO:0006914 autophagy	1
NCOR1		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Derepresses transcription of CMA components	NCOR1;NFATC1		1
NEMF		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
NFATC1		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Promotes transcription of LAMP2	NCOR1;NFATC1		1
NFKB2		GO:0006954	inflammatory response	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor|Inflammatory response	PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	NFKB1;NFKB2;REL;RELA;RELB		1
NFKB2		GO:0071159	NF-kappaB complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml;pn_regulation.yaml	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor;PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor;PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	NFKB1;NFKB2;REL;RELA;RELB	GO:0005634 nucleus	2
NFXL1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX|transmembrane	MID1;MID2;TRIM36;TRIM46;TRIM9		1
NGDN		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	BOP1;DDX27;PELP1;PES1;WDR12		1
NGLY1		GO:0006517	protein deglycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	ENGASE;MAN2C1;NGLY1		1
NGLY1		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
NKRF		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	BOP1;DDX27;PELP1;PES1;WDR12		1
NKRF		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	AATF;IMP3;NOP56;UTP4		1
NLN		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
NLRX1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1		1
NOL10		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex	BOP1;DDX27;PELP1;PES1;WDR12		1
NOL11		GO:0032040	small-subunit processome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex	HEATR1;UTP15;UTP4;WDR43;WDR75	GO:0005634 nucleus;GO:0005730 nucleolus	1
NOMO1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
NOMO1		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
NOMO2		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
NOMO2		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
NOMO3		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
NOMO3		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
NOP2		GO:0032040	small-subunit processome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex	HEATR1;UTP15;UTP4;WDR43;WDR75	GO:0005634 nucleus;GO:0005730 nucleolus	1
NOP53		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
NPLOC4		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitin recognition	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
NPM1		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NPM2		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NPM3		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
NSD2		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase	MID1;MID2;TRIM36;TRIM46;TRIM9		1
NUB1		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
NUDC		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
NUDCD1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
NUDCD2		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
NUDCD3		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
NUFIP1		GO:0034517	ribophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ribophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ribophagy	NUFIP1		1
NUP160		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
NUP205		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
NUP210		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
NUP37		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
NUP43		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
NUP58		GO:0015031	protein transport	supported_by_goa_regulation	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2	GO:0042306 regulation of protein import into nucleus	1
NUP62CL		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
OAZ1		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|antizyme	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		1
ODF1		GO:0044183	protein folding chaperone	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	Cytonuclear proteostasis|Chaperone|small HSP system|small HSP	HSPB1;HSPB2;HSPB3;HSPB6;HSPB7		1
OGT		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|O-GlcNAclyation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
OMA1		GO:0005759	mitochondrial matrix	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	AFG3L2;CLPX;PITRM1;SPG7;YME1L1	GO:0005739 mitochondrion	1
OMA1		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
OPTN		GO:0035973	aggrephagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	MAP1S;NBR1;OPTN;SQSTM1;TOLLIP		1
OPTN		GO:0098792	xenophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	CALCOCO2;OPTN;SQSTM1;TAX1BP1;TRIM5	GO:1904417 positive regulation of xenophagy	1
OSBPL1A		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	ARL8A;ARL8B;MAP1LC3B;OSBPL1A;RILP;RUFY3;VAPA		2
OSTM1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91		1
OTUB1		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
OTUD3		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
OXA1L		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport	Mitochondrial proteostasis|Protein transport|Inner membrane import|For assembly of inner membrane complexes	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7		1
P3H1		GO:0032964	collagen biosynthetic process	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1	GO:0032963 collagen metabolic process	1
P3H2		GO:0032964	collagen biosynthetic process	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1	GO:0032963 collagen metabolic process	1
P4HA1		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
P4HA2		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
P4HA3		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
P4HB		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
PAAF1		GO:0043248	proteasome assembly	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone;Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|WD40	PAAF1;POMP;PSMD10;PSMD5;PSMD9;PSMG1;PSMG2;PSMG3;PSMG4		2
PABPC1		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC1		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PABPC1L		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC1L		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PABPC1L2A		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC1L2A		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PABPC1L2B		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC1L2B		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PABPC3		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC3		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PABPC4		GO:0003743	translation initiation factor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H	GO:0006412 translation	1
PABPC4		GO:0006413	translational initiation	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B	GO:0006412 translation	1
PABPC4L		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC4L		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PABPC5		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
PABPC5		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
PARK7		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
PARK7		GO:0035694	mitochondrial protein catabolic process	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ANKZF1;FAF2;MARCHF5;USP30;VCP	GO:0007005 mitochondrion organization	1
PARL		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901524 regulation of mitophagy	1
PARN		GO:0006364	rRNA processing	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	EXOSC10;FCF1;NOB1;PARN;RMRP		1
PARN		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease	AATF;IMP3;NOP56;UTP4		1
PCGF1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9		2
PCGF2		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9		2
PCGF6		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb	BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9		2
PDCD6IP		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Localization of the ESCRT-III complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
PDCL3		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
PDF		GO:0034982	mitochondrial protein processing	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Methionine deformylation	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3		1
PDLIM2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|BTRC specific	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		1
PDZRN4		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
PELO		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
PELP1		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	BOP1;DDX27;PELP1;PES1;WDR12		1
PEX12		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PEX|transmembrane	MID1;MID2;TRIM36;TRIM46;TRIM9	GO:0004842 ubiquitin-protein transferase activity	1
PGAM5		GO:0000423	mitophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:0016236 macroautophagy	1
PGGHG		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
PHF23		GO:0098792	xenophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Suppressor of intracellular pathogen ubiquitination	LRSAM1;PHF23;RNF166		1
PHIP		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
PHLPP1		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	AMBRA1;GFAP;MT-RNR2;PSME1;TP53		1
PHRF1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
PICALM		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator	PICALM;STX7;STX8;VAMP3;VAMP7;VTI1B		2
PIH1D1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
PIH1D2		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
PITHD1		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|PITH	ECPAS;PITHD1;PSME4;PSMF1		1
PITRM1		GO:0035694	mitochondrial protein catabolic process	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ANKZF1;FAF2;MARCHF5;USP30;VCP	GO:0030163 protein catabolic process	1
PLAA		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	PLAA;UBXN6;YOD1	GO:0016236 macroautophagy	2
PLBD1		GO:0120569	phospholipase activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1		1
PLD3		GO:0120569	phospholipase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase	PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1	GO:0003824 catalytic activity	1
PLEKHM1		GO:0097352	autophagosome maturation	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges ATG8 and HOPS complex	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges ATG8 and HOPS complex	PLEKHM1		1
PML		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|various CTD;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class V|SIM	ASB2;FBXW4;FBXW7;FBXW8;MID1;MID2;PML;TRIM36;TRIM46;TRIM9	GO:0061659 ubiquitin-like protein ligase activity	2
PMPCA		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis;GO:0016485 protein processing	1
PMPCB		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis;GO:0016485 protein processing	1
PNO1		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
PPARA		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91		1
PPARG		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91		1
PPIB		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
PPIL2		GO:0003755	peptidyl-prolyl cis-trans isomerase activity	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C		2
PPIL6		GO:0003755	peptidyl-prolyl cis-trans isomerase activity	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C		2
PPP1R15A		GO:0032055	negative regulation of translation in response to stress	more_specific_than_existing_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PPP1R15A;PPP1R15B	GO:0051246 regulation of protein metabolic process	1
PPP1R15A		GO:0140467	integrated stress response signaling	supported_by_goa_regulation	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A	GO:1903898 negative regulation of PERK-mediated unfolded protein response	1
PPP1R15B		GO:0006417	regulation of translation	more_specific_than_existing_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A	GO:0051246 regulation of protein metabolic process	1
PPP1R15B		GO:0032055	negative regulation of translation in response to stress	more_specific_than_existing_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	PPP1R15A;PPP1R15B	GO:0051246 regulation of protein metabolic process	1
PPP1R15B		GO:0140467	integrated stress response signaling	supported_by_goa_regulation	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Translation regulator|Integrated stress response	PN regulation|Translation regulator|Integrated stress response|Dephosphorylation of EIF2alpha/EIF2S1	EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A	GO:1903898 negative regulation of PERK-mediated unfolded protein response	1
PRORP		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
PSAP		GO:0030290	sphingolipid activator protein activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|General activator of glycosphingolipid degradation	Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|General activator of glycosphingolipid degradation	PSAP		1
PSMD6		GO:0008541	proteasome regulatory particle, lid subcomplex	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI	PSMD11;PSMD14;PSMD3;PSMD6;PSMD7	GO:0000502 proteasome complex;GO:0005838 proteasome regulatory particle;GO:0022624 proteasome accessory complex;GO:0032991 protein-containing complex	1
PSME1		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28	PSME1;PSME2;PSME3		1
PSME1		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of interaction between substrate and lysosome-p53	AMBRA1;GFAP;MT-RNR2;PSME1;TP53		1
PSME2		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28	PSME1;PSME2;PSME3		1
PSME3		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA	Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28	PSME1;PSME2;PSME3		1
PSTK		GO:0004812	aminoacyl-tRNA ligase activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	AARS1;CARS1;DARS1;EPRS1;FARSA		1
PTCD1		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA chaperone	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
PTCD3		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	MTIF2;MTIF3;PTCD3		1
PTCD3		GO:0070124	mitochondrial translational initiation	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Translation initiation	Translation|Mitochondrial translation|Translation initiation|assorted initiation factors	MTIF2;MTIF3;PTCD3	GO:0032543 mitochondrial translation	1
RAB11A		GO:1904715	negative regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Promotes transport of LAMP2A to the lysosome	BMAL1;RAB11A;RARA		1
RAB17		GO:0098792	xenophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	RAB17;RAB23		1
RAB23		GO:0098792	xenophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy	RAB17;RAB23		1
RAB26		GO:0160247	autophagy cargo adaptor activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Synaptophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Synaptophagy	RAB26		1
RAB2A		GO:0097352	autophagosome maturation	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges STX17, RUBCNL and HOPS complex	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges STX17, RUBCNL and HOPS complex	RAB2A	GO:0016236 macroautophagy	1
RAB5IF		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
RAB5IF		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
RAB7B		GO:0061724	lipophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Recruiting autophagy factors to lipid droplets	ADRB2;AUP1;RAB7A;RAB7B;UBE2G2		1
RAB8B		GO:0031201	SNARE complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex	RAB8B;SNAP29;STX17;STX7;YKT6		1
RABGEF1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy	CALCOCO2;RABGEF1		1
RAC1		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization	AMBRA1;GFAP;MT-RNR2;PSME1;TP53		1
RACK1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
RACK1		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
RACK1		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	AATF;IMP3;NOP56;UTP4		1
RAD50		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex /  ATPase	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
RAE1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
RAE1		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S export adapter	AATF;IMP3;NOP56;UTP4		1
RANBP2		GO:0003755	peptidyl-prolyl cis-trans isomerase activity	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type	AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C		2
RANGAP1		GO:0015031	protein transport	supported_by_goa_regulation	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	GLE1;NUP214;NUP88;RAE1;RANBP2	GO:0046826 negative regulation of protein export from nucleus	1
RAPSN		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|TPR	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RARA		GO:1904715	negative regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Represses transcription of CMA components	BMAL1;RAB11A;RARA		1
RBBP4		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
RBBP7		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
RBBP8		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|DNA endonuclease	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
RBM10		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
RBM44		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|UBA-like (other)	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
RBM6		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
RCBTB1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|RCC1	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
RCBTB2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|RCC1	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
RCC1		GO:0006913	nucleocytoplasmic transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	RAN;RANBP2;RANGAP1;RGPD1;RGPD2		1
RCC1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	GLE1;NUP214;NUP88;RAE1;RANBP2		1
RCC1L		GO:0006913	nucleocytoplasmic transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	RAN;RANBP2;RANGAP1;RGPD1;RGPD2		1
RCC1L		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear transport, RAN system	GLE1;NUP214;NUP88;RAE1;RANBP2		1
REL		GO:0071159	NF-kappaB complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml;pn_regulation.yaml	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor;PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor;PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	NFKB1;NFKB2;REL;RELA;RELB	GO:0005634 nucleus	2
RELB		GO:0071159	NF-kappaB complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml;pn_regulation.yaml	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor;PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	Autophagy-Lysosome Pathway|Autophagy gene expression|NFkB transcriptional program|Component of NFkB transcription factor;PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component	NFKB1;NFKB2;REL;RELA;RELB	GO:0005634 nucleus;GO:0032991 protein-containing complex	2
RETREG2		GO:0061709	reticulophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy	RETREG1;RETREG2;RETREG3;RTN3;SEC62		1
REXO2		GO:0006364	rRNA processing	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	REXO2;ZFP42	GO:0006139 nucleobase-containing compound metabolic process;GO:0016070 RNA metabolic process	1
REXO2		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	AATF;IMP3;NOP56;UTP4		1
RHBDL3		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBQLN1;UBQLN2;UBXN4;UBXN8;VCP		2
RHOBTB1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
RHOBTB3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
RICTOR		GO:1904715	negative regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Modulator of LAMP2A multimerization	AKT1;CTSA;RICTOR		1
RICTOR		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|non-canonical	FBXL2;FBXL3;FBXL4;FBXL5;SKP2	GO:0060090 molecular adaptor activity;GO:0140767 enzyme-substrate adaptor activity	1
RILP		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3		3
RNF113B		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|C3H1-type ZnF	MID1;MID2;TRIM36;TRIM46;TRIM9	GO:0004842 ubiquitin-protein transferase activity	1
RNF123		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex|catalytic / RING, SPRY	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
RNF14		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
RNF141		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9	GO:0004842 ubiquitin-protein transferase activity	1
RNF166		GO:0098792	xenophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Catalyzes K33-linked ubiquitination of p62	LRSAM1;PHF23;RNF166		1
RNF17		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RNF170		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|catalytic / RING, transmembrane	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
RNF170		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
RNF185		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|catalytic / RING, transmembrane	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
RNF185		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	BNIP1;MARCHF5;RNF185;TANK;TBK1		1
RNF207		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RNF212		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RNF214		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|TTC3/DZIP3;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBA-like (other)	ASB2;FBXW4;FBXW7;FBXW8;MID1;MID2;PML;TRIM36;TRIM46;TRIM9	GO:0004842 ubiquitin-protein transferase activity	2
RNF222		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RNF24		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|Golgi	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RNF25		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
RNF32		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RNF41		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
RNF5		GO:2000785	regulation of autophagosome assembly	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Modulation of ATG4 activity	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Modulation of ATG4 activity	RNF5		1
RNFT1		GO:0036503	ERAD pathway	supported_by_goa_regulation	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K	GO:1904294 positive regulation of ERAD pathway	2
RPAP3		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and RPAP3-like C-terminal domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
RPF2		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
RPUSD4		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
RPUSD4		GO:0120159	rRNA pseudouridine synthase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation	RPUSD4	GO:0009982 pseudouridine synthase activity	1
RRP12		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
RRP12		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	AATF;IMP3;NOP56;UTP4		1
RRP36		GO:0032040	small-subunit processome	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex	HEATR1;UTP15;UTP4;WDR43;WDR75	GO:0005730 nucleolus	1
RRP8		GO:0000154	rRNA modification	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	BUD23;EMG1;LOC124902573;NAT10;TSR3		1
RRP8		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification	AATF;IMP3;NOP56;UTP4		1
RSL24D1		GO:0000027	ribosomal large subunit assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation	BCCIP;RSL24D1	GO:0042273 ribosomal large subunit biogenesis	1
RSPRY1		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|Armadillo	MID1;MID2;TRIM36;TRIM46;TRIM9	GO:0004842 ubiquitin-protein transferase activity	1
RUBCN		GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	BECN1;PIK3C3;PIK3R4;SH3GLB1;UVRAG		1
RUBCNL		GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	BECN1;PIK3C3;PIK3R4;SH3GLB1;UVRAG		1
RUFY1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
RUFY3		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4		3
RUFY4		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging	ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4		3
RUVBL1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
RUVBL2		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
S100A1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
SAMTOR		GO:1990130	GATOR1 complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex modulator	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex modulator	SAMTOR		1
SANBR		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
SAR1B		GO:0061700	GATOR2 complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator	SAR1B;SESN1;SESN2;SESN3		1
SART1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91		1
SBDS		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
SCAF11		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
SCYL1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SCYL3		GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	COPA;COPB1;COPB2;COPE;COPG1		1
SCYL3		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SCYL3		GO:0030126	COPI vesicle coat	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi	GORAB;SCYL1;SCYL3	GO:0005737 cytoplasm;GO:0005794 Golgi apparatus	1
SDE2		GO:0006281	DNA repair	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair	SDE2		1
SEC11A		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER signal peptidase	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SEC11C		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER signal peptidase	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SEC23IP		GO:0030127	COPII vesicle coat	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml;er_proteostasis.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component;ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ER membrane input|COPII vesicle component;ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	SEC13;SEC23A;SEC23B;SEC31A;SEC31B	GO:0005737 cytoplasm;GO:0012507 ER to Golgi transport vesicle membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle	2
SEC31A		GO:0015031	protein transport	supported_by_goa_regulation	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62	GO:0070863 positive regulation of protein exit from endoplasmic reticulum	1
SEC31B		GO:0015031	protein transport	supported_by_goa_regulation	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER-Golgi trafficking|Anterograde transport|COPII vesicle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62	GO:0070863 positive regulation of protein exit from endoplasmic reticulum	1
SEC62		GO:0005784	Sec61 translocon complex	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis|Protein transport|SEC61 channel complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62	GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005791 rough endoplasmic reticulum;GO:0016020 membrane	1
SEC63		GO:0005784	Sec61 translocon complex	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|SEC61 channel complex component	ER proteostasis|Protein transport|SEC61 channel complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62	GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane	1
SEC63		GO:0030544	Hsp70 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone	DNAJA3;DNAJB1;DNAJB6;HSCB	GO:0005515 protein binding	1
SECISBP2		GO:0003746	translation elongation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	Translation|Cytosolic translation|Translation elongation|assorted elongation factors	EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT		1
SEH1L		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Protein transport	Nuclear proteostasis|Protein transport|Nuclear pore complex	GLE1;NUP214;NUP88;RAE1;RANBP2		1
SELENOF		GO:0006487	protein N-linked glycosylation	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Glycoproteostasis|N-glycosylation system	ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Re-glucosylation	DAD1;DDOST;MAGT1;OSTC;RPN1		1
SEPSECS		GO:0004812	aminoacyl-tRNA ligase activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	Translation|Cytosolic translation|Translation elongation|tRNA synthetase	AARS1;CARS1;DARS1;EPRS1;FARSA		1
SERP1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|SEC61 channel accessory protein	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SERP2		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|SEC61 channel accessory protein	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SERPINH1		GO:0032964	collagen biosynthetic process	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding	P4HA1;P4HA2;P4HA3;P4HB;PLOD1		1
SET		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
SGTA		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SGTA		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and SGTA dimerization domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
SGTB		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SH3GLB1		GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	BECN1;PIK3C3;PIK3R4;SH3GLB1;UVRAG	GO:0016020 membrane;GO:0032991 protein-containing complex	1
SHARPIN		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex	RBCK1;SHARPIN	GO:0004842 ubiquitin-protein transferase activity	1
SHKBP1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
SIAH1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
SLC25A4		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901526 positive regulation of mitophagy	1
SLC25A5		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901526 positive regulation of mitophagy	1
SMN1		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
SMN2		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
SMYD4		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and methyltransferase domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
SNCAIP		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
SNORD3A		GO:0032040	small-subunit processome	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome	Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex	HEATR1;UTP15;UTP4;WDR43;WDR75		1
SPAG1		GO:0031072	heat shock protein binding	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and RPAP3-like C-terminal domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4		1
SPCS1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER signal peptidase	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SPCS2		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER signal peptidase	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SPCS3		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|ER signal peptidase	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SPG7		GO:0005759	mitochondrial matrix	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	AFG3L2;CLPX;PITRM1;SPG7;YME1L1	GO:0005739 mitochondrion	1
SPG7		GO:0035694	mitochondrial protein catabolic process	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	ANKZF1;FAF2;MARCHF5;USP30;VCP	GO:0007005 mitochondrion organization	1
SPNS1		GO:0007041	lysosomal transport	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products	Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products	SPNS1		1
SPOP		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
SPOPL		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH	ENC1;GAN;IPP;KBTBD2;KBTBD3		1
SQSTM1		GO:0070628	proteasome binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|PB1|UBA	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B	GO:0044877 protein-containing complex binding	1
SQSTM1		GO:0098792	xenophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	CALCOCO2;OPTN;SQSTM1;TAX1BP1;TRIM5	GO:0006914 autophagy;GO:0016236 macroautophagy	1
SQSTM1		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	NBR1;SQSTM1;TRIM17	GO:0006914 autophagy;GO:0016236 macroautophagy;GO:0030674 protein-macromolecule adaptor activity	1
SREBF1		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901524 regulation of mitophagy	1
SREBF2		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901524 regulation of mitophagy	1
SRP19		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Signal recognition particle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SRP68		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Signal recognition particle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SRP72		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Signal recognition particle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SRP9		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Signal recognition particle component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SRPRB		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|SRP receptor subunit	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
SSRP1		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
ST13		GO:0061684	chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8		1
ST13		GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	HSP90AA1;HSP90AB1;ST13;STIP1;STUB1		1
STIP1		GO:0061684	chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8		1
STIP1		GO:0061738	late endosomal microautophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy	DNAJB1;HSPA8;STIP1		1
STIP1		GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	HSP90AA1;HSP90AB1;ST13;STIP1;STUB1		1
STUB1		GO:0035973	aggrephagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component	BAG3;HSPA8;HSPB8;STUB1		1
STUB1		GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection	HSP90AA1;HSP90AB1;ST13;STIP1;STUB1	GO:0030163 protein catabolic process;GO:0061684 chaperone-mediated autophagy	1
STX12		GO:0000815	ESCRT III complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3	GO:0010008 endosome membrane;GO:0012505 endomembrane system;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0031982 vesicle	1
STX7		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	STX7;STX8;VAMP3;VAMP7;VTI1B		2
STX8		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	STX7;STX8;VAMP3;VAMP7;VTI1B		2
SUGT1		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR and CS domain containing	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
SUPT6H		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
SVIP		GO:0036503	ERAD pathway	supported_by_goa_regulation	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates	DERL1;DERL2;DERL3;ERLIN1;ERLIN2;HERPUD1;JKAMP;SVIP;SYVN1;TMUB1	GO:1904293 negative regulation of ERAD pathway	2
TANK		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	BNIP1;MARCHF5;RNF185;TANK;TBK1		1
TAX1BP1		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1		1
TAX1BP1		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1		2
TAX1BP1		GO:0098792	xenophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	CALCOCO2;OPTN;SQSTM1;TAX1BP1;TRIM5		1
TBC1D15		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1		1
TBC1D17		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1		1
TBK1		GO:0000423	mitophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy	BNIP1;MARCHF5;RNF185;TANK;TBK1	GO:0016236 macroautophagy	1
TBL3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|WD40	AHR;ARNT;COP1;DCAF13;DCAF7		1
TCF25		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
TCIRG1		GO:0046610	lysosomal proton-transporting V-type ATPase, V0 domain	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1	GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016020 membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain	1
TELO2		GO:0031931	TORC1 complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component	AKT1S1;DEPTOR;MLST8;MTOR;RPTOR		1
TELO2		GO:0031932	TORC2 complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component	DEPTOR;MAPKAP1;MLST8;MTOR;RICTOR		1
TEX10		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	BOP1;DDX27;PELP1;PES1;WDR12		1
TIMM29		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport	Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7		1
TMA16		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
TMCO1		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
TMCO1		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
TMEM106B		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
TMEM147		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
TMEM147		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
TMEM175		GO:0007042	lysosomal lumen acidification	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification	Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification	ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1		1
TMEM183A		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
TMEM183BP		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane	FBXL2;FBXL3;FBXL4;FBXL5;SKP2		1
TMEM259		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
TMUB1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
TMUB2		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
TMX2		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
TMX4		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
TNFAIP3		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|OTU & A20	KAT2B;PPARA;PPARG;TNFAIP3;ZFP91	GO:0003824 catalytic activity;GO:0004842 ubiquitin-protein transferase activity	1
TOLLIP		GO:0035973	aggrephagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy	MAP1S;NBR1;OPTN;SQSTM1;TOLLIP		1
TOM1		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin	ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1		2
TOMM20L		GO:0045040	protein insertion into mitochondrial outer membrane	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport|Outer membrane import	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7		1
TOMM40L		GO:0045040	protein insertion into mitochondrial outer membrane	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport|Outer membrane import	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7	GO:0008150 biological_process	1
TOMM5		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7		1
TOMM6		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport	Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7		1
TOMM70		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
TONSL		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
TOPBP1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|BRCT	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
TOR1AIP2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
TP53		GO:1904716	positive regulation of chaperone-mediated autophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer	Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of HSPA8 role in assembly of LAMP2A	AMBRA1;GFAP;MT-RNR2;PSME1;TP53		1
TRIB3		GO:0006954	inflammatory response	new_to_goa	ok_for_propagation_to_go	pn_regulation.yaml	PN regulation|Transcription factor regulator|Inflammatory response	PN regulation|Transcription factor regulator|Inflammatory response|NFkB modulator	TRIB3		1
TRIM13		GO:0061709	reticulophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins	DDRGK1;TRIM13;UBA5;UFC1;UFL1		2
TRIM16		GO:0160247	autophagy cargo adaptor activity	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy	CALCOCO2;TRIM16		1
TRIM16L		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY & folded central helix	MID1;MID2;TRIM36;TRIM46;TRIM9		1
TRIM17		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Midbody autophagy	NBR1;SQSTM1;TRIM17	GO:0006914 autophagy;GO:0030674 protein-macromolecule adaptor activity	1
TRIM29		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD	MID1;MID2;TRIM36;TRIM46;TRIM9		1
TRIM46		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	MID1;MID2;TRIM36;TRIM46;TRIM9		1
TRIM5		GO:0098792	xenophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy	CALCOCO2;OPTN;SQSTM1;TAX1BP1;TRIM5	GO:0006914 autophagy	1
TRIM66		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD	MID1;MID2;TRIM36;TRIM46;TRIM9		1
TRIM67		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY	MID1;MID2;TRIM36;TRIM46;TRIM9		1
TRIP4		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
TRMT10C		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
TRMT112		GO:0030688	preribosome, small subunit precursor	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1	GO:0032991 protein-containing complex	1
TRMT2B		GO:0000154	rRNA modification	more_specific_than_existing_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B	GO:0006396 RNA processing	1
TRMT2B		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
TRMT61B		GO:0000154	rRNA modification	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	MRM1;MRM2;MRM3;RPUSD4;TRMT61B		1
TRMT61B		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B		1
TSG101		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
TSPO		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Inhibits mitochondrial protein ubiquitination	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901525 negative regulation of mitophagy	1
TSR1		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
TSR2		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
TSR3		GO:0030688	preribosome, small subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex	BUD23;BYSL;EIF5B;LTV1;NOB1		1
TTC1		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
TTC12		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and Armadillo domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
TTC3		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
TTC9B		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0003674 molecular_function	1
TTC9C		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
TUFM		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy	CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1		1
TXNDC11		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
TXNDC12		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
TXNDC16		GO:0003756	protein disulfide isomerase activity	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Folding enzyme|Protein disulfide isomerases	ER proteostasis|Folding enzyme|Protein disulfide isomerases	AGR2;AGR3;CASQ1;CASQ2;DNAJC10		1
UBA5		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UBAC1		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBAC2		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / UBA, transmembrane	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
UBAP1		GO:0000045	autophagosome assembly	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C		1
UBAP2		GO:0006281	DNA repair	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2)	ABRAXAS1;ABRAXAS2;BABAM2;GCNA;POLH		1
UBAP2L		GO:0006281	DNA repair	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair	Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2)	ABRAXAS1;ABRAXAS2;BABAM2;GCNA;POLH		1
UBE2D1		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
UBE2D2		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
UBE2D3		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
UBE2G1		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
UBE2G2		GO:0061724	lipophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Ubiquitination of lipid droplet surface proteins	ADRB2;AUP1;RAB7A;RAB7B;UBE2G2		1
UBE2K		GO:0036503	ERAD pathway	new_to_goa	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K		2
UBE2L3		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
UBE2N		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
UBL4A		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|GET pathway component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
UBL7		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBN1		GO:0140713	histone chaperone activity	new_to_goa	ok_for_propagation_to_go	nuclear_proteostasis.yaml	Nuclear proteostasis|Chaperone|Histone chaperone	Nuclear proteostasis|Chaperone|Histone chaperone	ASF1A;ASF1B;CHAF1A;NPM1		1
UBQLN1		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
UBQLN1		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBQLN1		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B		2
UBQLN2		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
UBQLN2		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBQLN2		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B		2
UBQLN3		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
UBQLN3		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBQLN3		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B		2
UBQLN4		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
UBQLN4		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBQLN4		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA	AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B		2
UBQLNL		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
UBQLNL		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		1
UBR4		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|catalytic subunit	CALM1;KCMF1;UBR4		1
UBTD1		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBD	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBTD2		GO:0043130	ubiquitin binding	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding	Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBD	RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3	GO:0005515 protein binding	1
UBXN6		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	PLAA;UBXN6;YOD1	GO:0016236 macroautophagy	2
UFC1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UFD1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|VCP system for RQC	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UFD1		GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor	Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|idiosyncratic Ub binding / UT3	AUP1;UFD1	GO:0036503 ERAD pathway	1
UFL1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UFM1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UFSP1		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UFSP2		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
UFSP2		GO:0071569	protein ufmylation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	Translation|Cytosolic translation|Ribosome-associated QC|UFMylation	DDRGK1;UBA5;UFC1;UFL1;UFM1		1
UIMC1		GO:0000151	ubiquitin ligase complex	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding	GID8;MAEA;RANBP10;RMND5A;RMND5B		1
ULK2		GO:1990316	Atg1/ULK1 kinase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ATG13;RB1CC1;ULK1;ULK2;ULK3	GO:0005737 cytoplasm	1
ULK3		GO:1990316	Atg1/ULK1 kinase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ULK1 pathway, direct|ULK1 complex component	ATG13;RB1CC1;ULK1;ULK2;ULK3	GO:0005737 cytoplasm	1
UMAD1		GO:0000045	autophagosome assembly	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C		1
UMAD1		GO:0000813	ESCRT I complex	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C		1
UNK		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF	MID1;MID2;TRIM36;TRIM46;TRIM9		1
UNKL		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF	MID1;MID2;TRIM36;TRIM46;TRIM9		1
UPF1		GO:0006415	translational termination	supported_by_goa_regulation	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|Modulation of termination	ABCE1;EIF2D;ETF1;GSPT1;GSPT2	GO:0006449 regulation of translational termination	1
UPF2		GO:0006415	translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|Modulation of termination	ABCE1;EIF2D;ETF1;GSPT1;GSPT2		1
UPF3A		GO:0006415	translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|Modulation of termination	ABCE1;EIF2D;ETF1;GSPT1;GSPT2		1
UPF3B		GO:0006415	translational termination	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation termination	Translation|Cytosolic translation|Translation termination|Modulation of termination	ABCE1;EIF2D;ETF1;GSPT1;GSPT2		1
USP10		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
USP14		GO:0036503	ERAD pathway	supported_by_goa_regulation	exact;ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates	ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB	DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K	GO:1904293 negative regulation of ERAD pathway	2
USP15		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
USP21		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
USP30		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901525 negative regulation of mitophagy	1
USP30		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
USP35		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
USP8		GO:0000423	mitophagy	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN		1
UVRAG		GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component	BECN1;PIK3C3;PIK3R4;SH3GLB1;UVRAG	GO:0032991 protein-containing complex	1
VAMP2		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	STX7;STX8;VAMP3;VAMP7;VTI1B		2
VAMP3		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	STX7;STX8;VAMP3;VAMP7;VTI1B		2
VAMP7		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	STX7;STX8;VAMP3;VAMP7;VTI1B		2
VAPA		GO:0061906	autophagosome localization	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER	ARL8A;ARL8B;MAP1LC3B;OSBPL1A;RILP;RUFY3;VAPA		2
VCP		GO:0003743	translation initiation factor activity	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H		1
VCP		GO:0006413	translational initiation	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Translation initiation	Translation|Cytosolic translation|Translation initiation|assorted initiation factors	EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B		1
VCP		GO:0035694	mitochondrial protein catabolic process	new_to_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation	Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway	ANKZF1;FAF2;MARCHF5;USP30;VCP		1
VCP		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lysophagy|ELDR complex component	VCP	GO:0006914 autophagy;GO:0016236 macroautophagy	2
VDAC1		GO:0000423	mitophagy	supported_by_goa_regulation	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway	CLEC16A;PARL;PGAM5;PINK1;PRKN	GO:1901524 regulation of mitophagy;GO:1901526 positive regulation of mitophagy;GO:1905091 positive regulation of type 2 mitophagy	1
VPS13D		GO:0000423	mitophagy	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Mitophagy|Binding of ubiquitin-marked mitochondria	FBXO7;VPS13D	GO:0016236 macroautophagy	1
VPS28		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
VPS37A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Localization of the ESCRT-III complex	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	2
VPS37B		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
VPS37C		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
VPS37D		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0016236 macroautophagy	1
VPS41		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40	MID1;MID2;TRIM36;TRIM46;TRIM9		1
VPS4A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0007033 vacuole organization;GO:0016236 macroautophagy	1
VPS4A		GO:0000815	ESCRT III complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3	GO:0005737 cytoplasm;GO:0005768 endosome;GO:0010008 endosome membrane	1
VPS4B		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0007033 vacuole organization;GO:0016236 macroautophagy	1
VPS4B		GO:0000815	ESCRT III complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3	GO:0005737 cytoplasm;GO:0005768 endosome;GO:0010008 endosome membrane	1
VPS8		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40	MID1;MID2;TRIM36;TRIM46;TRIM9		1
VTI1A		GO:0000045	autophagosome assembly	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane	Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-III complex activity modulator	TSG101;VPS28;VPS37A;VPS37B;VPS37C	GO:0006914 autophagy;GO:0016236 macroautophagy	1
VTI1A		GO:0000815	ESCRT III complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	Autophagy-Lysosome Pathway|Microautophagy|General microautophagy machinery|ESCRT-III complex component	CHMP1A;CHMP1B;CHMP2A;CHMP2B;CHMP3	GO:0005737 cytoplasm;GO:0005768 endosome;GO:0012505 endomembrane system;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0098588 bounding membrane of organelle	1
VTI1B		GO:1905686	positive regulation of plasma membrane repair	new_to_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex	STX7;STX8;VAMP3;VAMP7;VTI1B		2
WDR18		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex	BOP1;DDX27;PELP1;PES1;WDR12		1
WDR45		GO:0062079	ATG2-ATG18 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ATG2A;ATG2B;WDR45B;WIPI1;WIPI2	GO:0000407 phagophore assembly site;GO:0005737 cytoplasm;GO:0034045 phagophore assembly site membrane	1
WDR45B		GO:0062079	ATG2-ATG18 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ATG2A;ATG2B;WDR45B;WIPI1;WIPI2	GO:0000407 phagophore assembly site;GO:0034045 phagophore assembly site membrane	1
WDR83OS		GO:0015031	protein transport	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62		1
WDR83OS		GO:0044743	protein transmembrane import into intracellular organelle	new_to_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	NCLN;NOMO1;RAB5IF;TMCO1;TMEM147		1
WDR83OS		GO:0160005	PAT complex	more_specific_than_existing_goa	ok_for_propagation_to_go	er_proteostasis.yaml	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component	CCDC47;WDR83OS	GO:0005789 endoplasmic reticulum membrane	1
WDSUB1		GO:0061630	ubiquitin protein ligase activity	more_specific_than_existing_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|WD40	PRPF19;STUB1;UBE4A;UBOX5;WDSUB1	GO:0004842 ubiquitin-protein transferase activity	1
WDTC1		GO:0031072	heat shock protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	DNAAF4;DNAJC7;SMYD4;TTC12;TTC4	GO:0005515 protein binding	1
WDTC1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase	LONRF3;STUB1;TTC3;WDTC1		1
WDTC1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|TPR	BRWD1;BRWD3;DCAF1;DCAF6;PHIP		1
WIPI1		GO:0062079	ATG2-ATG18 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ATG2A;ATG2B;WDR45B;WIPI1;WIPI2	GO:0000407 phagophore assembly site;GO:0005737 cytoplasm;GO:0034045 phagophore assembly site membrane	1
WIPI2		GO:0062079	ATG2-ATG18 complex	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component	ATG2A;ATG2B;WDR45B;WIPI1;WIPI2	GO:0000407 phagophore assembly site;GO:0016020 membrane;GO:0032991 protein-containing complex;GO:0034045 phagophore assembly site membrane	1
XPNPEP3		GO:0017087	mitochondrial processing peptidase complex	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0005737 cytoplasm;GO:0005739 mitochondrion	1
XPNPEP3		GO:0034982	mitochondrial protein processing	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Mitochondrial protein maturation	Mitochondrial proteostasis|Mitochondrial protein maturation|Processing peptidase	IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3	GO:0006508 proteolysis;GO:0016485 protein processing	1
XRN2		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex	BOP1;DDX27;PELP1;PES1;WDR12		1
YBEY		GO:0061668	mitochondrial ribosome assembly	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Mitochondrial translation|Mitoribosome biogenesis factor;Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly	Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly	METTL15;MTERF4;NSUN4;TFB1M;TRMT2B;YBEY		2
YME1L1		GO:0005759	mitochondrial matrix	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease	AFG3L2;CLPX;PITRM1;SPG7;YME1L1	GO:0005739 mitochondrion	1
YOD1		GO:0160247	autophagy cargo adaptor activity	more_specific_than_existing_goa	ok_for_propagation_to_go	autophagy_lysosome_pathway.yaml	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	Autophagy-Lysosome Pathway|Autophagy substrate selection|Substrate selectivity regulator for selective autophagy|Lysophagy|ELDR complex component	PLAA;UBXN6;YOD1	GO:0016236 macroautophagy	2
YPEL1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		1
YPEL2		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		1
YPEL3		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		1
YPEL4		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific	IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2		1
YWHAE		GO:0015031	protein transport	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport;Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7;YWHAE;YWHAZ	GO:0008104 intracellular protein localization	2
YWHAZ		GO:0015031	protein transport	more_specific_than_existing_goa	ok_for_propagation_to_go	mitochondrial_proteostasis.yaml	Mitochondrial proteostasis|Protein transport;Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	Mitochondrial proteostasis|Protein transport|Cytosolic mitochondria import stimulation factor	TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7;YWHAE;YWHAZ	GO:0008104 intracellular protein localization	2
ZER1		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZER1 group / Armadillo-like	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		1
ZFAND2A		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UBZ;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|UBZ (ZFAND2A/B)	AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B		2
ZFAND2B		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UIM;Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor|with AN1|UIM, UBZ (ZFAND2A/B)	AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B		2
ZFAND5		GO:0070628	proteasome binding	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor	Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|A20;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|A20 ZnF	AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B		2
ZFP42		GO:0006364	rRNA processing	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	REXO2;ZFP42		1
ZFP42		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease	AATF;IMP3;NOP56;UTP4		1
ZFPL1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
ZFTRAF1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|other	MID1;MID2;TRIM36;TRIM46;TRIM9		1
ZMYND10		GO:0051879	Hsp90 protein binding	more_specific_than_existing_goa	ok_for_propagation_to_go	chaperone_systems.yaml	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone	Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain	CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6	GO:0005515 protein binding	1
ZNF593		GO:0030687	preribosome, large subunit precursor	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	BOP1;DDX27;PELP1;PES1;WDR12		1
ZNF593		GO:0042254	ribosome biogenesis	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome biogenesis factor	Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex	AATF;IMP3;NOP56;UTP4		1
ZNF598		GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	new_to_goa	ok_for_propagation_to_go	translation.yaml	Translation|Cytosolic translation|Ribosome-associated QC	Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue	GTPBP1;GTPBP2;HBS1L;PELO;RACK1		1
ZNFX1		GO:0061630	ubiquitin protein ligase activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ|RNA helicase	RNF213;ZNFX1		1
ZRANB2		GO:0048024	regulation of mRNA splicing, via spliceosome	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing	Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF	RBM10;RBM44;RBM5;RBM6;ZRANB2		1
ZSWIM4		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		1
ZSWIM5		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		1
ZSWIM6		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM	ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8		1
ZYG11A		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like	APPBP2;FEM1A;FEM1B;FEM1C;VHL		1
ZYG11B		GO:1990756	ubiquitin-like ligase-substrate adaptor activity	new_to_goa	ok_for_propagation_to_go	ubiquitin_proteasome_system.yaml	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor	Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like, LRR	APPBP2;FEM1A;FEM1B;FEM1C;VHL		1