gene_symbol gene_name target_go_id target_go_label goa_status mapping_scopes mapping_files mapping_subjects pn_codes representative_genes supporting_goa_terms projection_count AAAS GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 AATF GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex BOP1;DDX27;PELP1;PES1;WDR12 1 ABCE1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ABCF2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ABRAXAS1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding GID8;MAEA;RANBP10;RMND5A;RMND5B 1 ABRAXAS2 GO:0006281 DNA repair new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component|idiosyncratic Ub binding / MPN ABRAXAS1;ABRAXAS2;BABAM2;GCNA;POLH 1 ABTB1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin ENC1;GAN;IPP;KBTBD2;KBTBD3 1 ABTB2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin ENC1;GAN;IPP;KBTBD2;KBTBD3 1 ABTB3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin, transmembrane ENC1;GAN;IPP;KBTBD2;KBTBD3 1 AGK GO:0015031 protein transport new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Protein transport Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7 1 AGR2 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 AGR3 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 AHCTF1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 AHR GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS AHR;ARNT;COP1;DCAF13;DCAF7 1 AIRE GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other PRPF19;STUB1;UBE4A;UBOX5;WDSUB1 1 AKIRIN1 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 1 AKIRIN2 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 1 ANAPC2 GO:0160072 ubiquitin ligase complex scaffold activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, APC sununit CUL1;CUL2;CUL3;CUL4A;CUL4B 1 ANKFY1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin ENC1;GAN;IPP;KBTBD2;KBTBD3 1 ANKZF1 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Vms pathway ANKZF1;FAF2;MARCHF5;USP30;VCP 1 ARL8A GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4 3 ARL8B GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4 3 ARNT GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS AHR;ARNT;COP1;DCAF13;DCAF7 1 ASCC1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ASCC1 GO:0072344 rescue of stalled cytosolic ribosome new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ASCC2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ASCC3 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ATAD1 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|mitoCPR pathway ANKZF1;FAF2;MARCHF5;USP30;VCP 1 ATAD3A GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway CLEC16A;PARL;PGAM5;PINK1;PRKN 1 ATF3 GO:0140467 integrated stress response signaling new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor|Integrated stress response;PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes PN regulation|Transcription factor|Integrated stress response|Transcription of integrated stress response genes ATF3;ATF4;DDIT3 2 ATL3 GO:0061709 reticulophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy RETREG1;RETREG2;RETREG3;RTN3;SEC62 1 ATP13A1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Removal of misinserted transmembrane proteins SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 ATP23 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease ANKZF1;FAF2;MARCHF5;USP30;VCP 1 ATP6AP1 GO:0060590 ATPase regulator activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump ATP6AP1;ATP6AP2;LRRK2 2 ATP6AP2 GO:0060590 ATPase regulator activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump;Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|Regulator of the lysosomal v-ATPase proton pump ATP6AP1;ATP6AP2;LRRK2 2 ATP6V1C1 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATP6V1C2 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATP6V1E1 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATP6V1E2 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATP6V1E2 GO:0033176 proton-transporting V-type ATPase complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V1A;ATP6V1B1;ATP6V1B2;ATP6V1C1;ATP6V1C2 1 ATP6V1G1 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATP6V1G2 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATP6V1G3 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V1 lysosomal v-ATPase proton pump component ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 ATRX GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 AZI2 GO:0098792 xenophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy AZI2;LGALS8 1 BABAM1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|other / RCC1, SPRY, WD40 GID8;MAEA;RANBP10;RMND5A;RMND5B 1 BAG2 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|BAG AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 1 BAZ1B GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|kinase, bromodomain MID1;MID2;TRIM36;TRIM46;TRIM9 1 BCCIP GO:0000027 ribosomal large subunit assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation BCCIP;RSL24D1 1 BCCIP GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation AATF;IMP3;NOP56;UTP4 1 BCL2L13 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1 1 BMAL1 GO:1904715 negative regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Negative regulator of transcription of CMA components BMAL1;RAB11A;RARA 1 BMI1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9 2 BNIP1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy BNIP1;MARCHF5;RNF185;TANK;TBK1 1 BRIP1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|DNA helicase GID8;MAEA;RANBP10;RMND5A;RMND5B 1 BRWD1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 BRWD3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 BTBD1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD10 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD16 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD17 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD6 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD7 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD8 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BTBD9 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 BUD23 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 BZW1 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 BZW2 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 CABIN1 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 CACUL1 GO:0160072 ubiquitin ligase complex scaffold activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, possible CUL3 inhibitor CUL1;CUL2;CUL3;CUL4A;CUL4B 1 CALCOCO1 GO:0061709 reticulophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy RETREG1;RETREG2;RETREG3;RTN3;SEC62 1 CALCOCO2 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;RABGEF1;SQSTM1;TAX1BP1 2 CALCOCO2 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1 2 CALCOCO2 GO:0160247 autophagy cargo adaptor activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy CALCOCO2;TRIM16 1 CALR GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 CALR3 GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 CAMLG GO:0003755 peptidyl-prolyl cis-trans isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type CAMLG;FKBP2;FKBP7;PPIB;PPIC 2 CAMLG GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|GET pathway component ER proteostasis|Protein transport|GET pathway component CAMLG;GET1;GET3;GET4;SGTA 1 CAMLG GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 CAND1 GO:1990757 ubiquitin ligase activator activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor;Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like CAND1;CAND2 2 CAND2 GO:1990757 ubiquitin ligase activator activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor;Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like CAND1;CAND2 2 CANX GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 CASQ1 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 CASQ2 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 CCDC47 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 CCDC47 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 CCDC50 GO:0160247 autophagy cargo adaptor activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates CCDC50;MEFV 1 CDK5RAP3 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 CGRRF1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 CHAF1A GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 CHAF1B GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 CHIC2 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex|noncatalytic CHIC2;STUB1 1 CLCN7 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 CLGN GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 CMYA5 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & FN & SPRY MID1;MID2;TRIM36;TRIM46;TRIM9 1 CNOT4 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 COLGALT1 GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 COLGALT2 GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 COP1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other AHR;ARNT;COP1;DCAF13;DCAF7 1 COPE GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI vesicle component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 CRBN GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|LON, Yippee, DOC BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 CRTAP GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 CRYAA GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP HSPB1;HSPB2;HSPB3;HSPB6;HSPB7 1 CSNK1D GO:0000045 autophagosome assembly new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|Specific function in sealing of autophagophore membrane unknown TSG101;VPS28;VPS37A;VPS37B;VPS37C 1 CSNK2B GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex AATF;IMP3;NOP56;UTP4 1 CWC27 GO:0003755 peptidyl-prolyl cis-trans isomerase activity new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C 2 CYB5R4 GO:0051879 Hsp90 protein binding new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing CACYBP;CHORDC1;CYB5R4;DNAAF11;DNAAF6 1 DCAF10 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF11 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF12L1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF12L2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF15 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF16 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF17 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF4 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF4L1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF4L2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF5 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF6 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|IQ motif BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF8 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF8L1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DCAF8L2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DDA1 GO:0160072 ubiquitin ligase complex scaffold activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold|(no type)|(no subtype) DDA1 1 DDB2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 DDRGK1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 DDX19B GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 DDX21 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex AATF;IMP3;NOP56;UTP4 1 DDX27 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex BOP1;DDX27;PELP1;PES1;WDR12 1 DDX3Y GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 DDX3Y GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 DELE1 GO:0006417 regulation of translation new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Translation regulator PN regulation|Translation regulator|Integrated stress response|EIF2AK1 modulator EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A 1 DENR GO:0006415 translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation termination Translation|Cytosolic translation|Translation termination|tRNA, mRNA release ABCE1;EIF2D;ETF1;GSPT1;GSPT2 1 DEPTOR GO:0031931 TORC1 complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component AKT1S1;DEPTOR;MLST8;MTOR;RPTOR 1 DEPTOR GO:0031932 TORC2 complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component DEPTOR;MAPKAP1;MLST8;MTOR;RICTOR 1 DHX15 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex BOP1;DDX27;PELP1;PES1;WDR12 1 DHX15 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex AATF;IMP3;NOP56;UTP4 1 DHX16 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|idiosyncratic Ub binding / other RBM10;RBM44;RBM5;RBM6;ZRANB2 1 DNAJB1 GO:0061684 chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8 1 DNAJB1 GO:0061738 late endosomal microautophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy DNAJB1;HSPA8;STIP1 1 DNAJB1 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy new_to_goa exact autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate delivery CLU;DNAJB1;HSPA8 1 DNAJC10 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 DNAJC16 GO:0030544 Hsp70 protein binding new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone DNAJA3;DNAJB1;DNAJB6;HSCB 1 DNAJC21 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 DNAJC21 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex AATF;IMP3;NOP56;UTP4 1 DNAJC24 GO:0030544 Hsp70 protein binding new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone DNAJA3;DNAJB1;DNAJB6;HSCB 1 DNAJC25 GO:0030544 Hsp70 protein binding new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone DNAJA3;DNAJB1;DNAJB6;HSCB 1 DNAJC5G GO:0030544 Hsp70 protein binding new_to_goa ok_for_propagation_to_go chaperone_systems.yaml ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone DNAJA3;DNAJB1;DNAJB6;HSCB 1 DRG2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 DUSP12 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 DUSP12 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex AATF;IMP3;NOP56;UTP4 1 ECT2L GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 EDEM1 GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming DAD1;DDOST;MAGT1;OSTC;RPN1 1 EDEM3 GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Mannose trimming DAD1;DDOST;MAGT1;OSTC;RPN1 1 EDF1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 EEF2KMT GO:0003746 translation elongation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation elongation|assorted elongation factors Translation|Cytosolic translation|Translation elongation|assorted elongation factors EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT 1 EIF2AK2 GO:0140467 integrated stress response signaling new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Translation regulator|Integrated stress response PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1 EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4;PPP1R15A 1 EIF2AK3 GO:1903894 regulation of IRE1-mediated unfolded protein response new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Translation regulator|Unfolded protein response;PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1 PN regulation|Translation regulator|Unfolded protein response|Phosphorylation of EIF2alpha/EIF2S1 EIF2AK3 2 EIF2AK4 GO:0032055 negative regulation of translation in response to stress new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1 PN regulation|Translation regulator|Integrated stress response|Phosphorylation of EIF2alpha/EIF2S1 EIF2AK1;EIF2AK2;EIF2AK3;EIF2AK4 1 EIF3J GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 EIF4E2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 EIF4EBP1 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 EIF4EBP3 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 EIF5A GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 EIF5B GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 EIF6 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 ELAC2 GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|RNAse Z METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 ELOA GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 EMC1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC1 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC10 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC10 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC2 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC2 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC3 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC3 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC4 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC4 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC6 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC6 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC7 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC7 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC8 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC8 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 EMC9 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 EMC9 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 ENGASE GO:0006517 protein deglycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates ENGASE;MAN2C1;NGLY1 1 ENGASE GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 ERN1 GO:1903894 regulation of IRE1-mediated unfolded protein response new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator PN regulation|Transcription factor regulator|Unfolded protein response|XBP1 modulator ERN1 1 ERO1A GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases;ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation AGR2;AGR3;CASQ1;CASQ2;DNAJC10;ERO1A;ERO1B 2 ERO1B GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases;ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation ER proteostasis|Folding enzyme|Protein disulfide isomerases|Protein disulfide isomerase reoxidation AGR2;AGR3;CASQ1;CASQ2;DNAJC10;ERO1A;ERO1B 2 ERP27 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 ERP29 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 FAF2 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway ANKZF1;FAF2;MARCHF5;USP30;VCP 1 FAM72A GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCA GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCB GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCC GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCE GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCF GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCG GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / TPR GID8;MAEA;RANBP10;RMND5A;RMND5B 1 FANCL GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|catalytic / RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|FANC / catalytic subunit|idiosyncratic Ub binding / ELF ANAPC11;ANAPC2;FANCL;GID8;KCMF1;MAEA;RANBP10;RMND5A;RMND5B;SHARPIN 2 FBH1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|DNA helicase FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL12 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL13 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL14 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL15 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL16 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL17 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL18 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL20 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL21P GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL22 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL5 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL6 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL7 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXL8 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO10 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO15 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO16 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO17 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO21 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO22 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO25 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO27 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO30 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO33 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO34 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO36 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO39 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO40 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO41 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO43 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO47 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO5 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO6 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXO8 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXW10 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXW12 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXW2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXW4 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40 ASB2;FBXW4;FBXW7;FBXW8;PML 1 FBXW4 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXW5 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FBXW7 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40 ASB2;FBXW4;FBXW7;FBXW8;PML 1 FBXW8 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40 ASB2;FBXW4;FBXW7;FBXW8;PML 1 FBXW9 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 FKBP6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type AIP;AIPL1;FKBP1A;FKBP1B;FKBP3 2 FYCO1 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3 2 GBF1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI coating and uncoating SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 GCN1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes;Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 2 GCN1 GO:0016567 protein ubiquitination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes GCN1;RNF14;RNF25 1 GET1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 GET3 GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|GET pathway component ER proteostasis|Protein transport|GET pathway component CAMLG;GET1;GET3;GET4;SGTA 1 GET3 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 GET4 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 GIGYF1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 GIGYF2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 GLE1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 GLMN GO:1904667 negative regulation of ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor GLMN 1 GMCL1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL ENC1;GAN;IPP;KBTBD2;KBTBD3 1 GMCL2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL ENC1;GAN;IPP;KBTBD2;KBTBD3 1 GNL2 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 GNL2 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex AATF;IMP3;NOP56;UTP4 1 GORAB GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi COPA;COPB1;COPB2;COPE;COPG1 1 GORAB GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 GTPBP1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 GTPBP2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 GTPBP4 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 GTPBP6 GO:0070126 mitochondrial translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Translation termination Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes MRPL58;MTRES1;MTRF1;MTRF1L;MTRFR 1 GTPBP6 GO:7770016 rescue of stalled mitochondrial ribosome new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes GTPBP6;MRPL58;MTRES1;MTRFR 1 HAP1 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons ARL8A;ARL8B;HAP1;HTT;MAP1LC3B;RILP;RUFY3 2 HAPSTR2 GO:0006950 response to stress new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Stress response integration PN regulation|Stress response integration|Multi-stress response|Modulation of stress responses HAPSTR1;HAPSTR2;HUWE1 1 HAT1 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 HBS1L GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 HEATR3 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 HERPUD2 GO:0036503 ERAD pathway new_to_goa exact er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Retrotranslocation channel complex DERL1;DERL2;DERL3;HERPUD1;SYVN1 1 HIRA GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 HJURP GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 HOXB4 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 HSD17B10 GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 HSF2 GO:0034605 cellular response to heat new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor|Heat shock response;PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes HSF1;HSF2;HSF4;HSF5 2 HSF4 GO:0034605 cellular response to heat new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor|Heat shock response;PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes HSF1;HSF2;HSF4;HSF5 2 HSF5 GO:0034605 cellular response to heat new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor|Heat shock response;PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes PN regulation|Transcription factor|Heat shock response|Transcription of heat shock response genes HSF1;HSF2;HSF4;HSF5 2 HSP90AB1 GO:0061684 chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8 1 HSP90AB1 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection HSP90AA1;HSP90AB1;ST13;STIP1;STUB1 1 HSPA8 GO:0035973 aggrephagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component BAG3;HSPA8;HSPB8;STUB1 1 HSPA8 GO:0061738 late endosomal microautophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy DNAJB1;HSPA8;STIP1 1 HSPB2 GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml;mitochondrial_proteostasis.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8 2 HSPB3 GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml;mitochondrial_proteostasis.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8 2 HSPB7 GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP HSPB1;HSPB2;HSPB3;HSPB6;HSPB7 1 HSPB8 GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml;mitochondrial_proteostasis.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP;Mitochondrial proteostasis|Chaperone|small HSP CRYAB;HSPB1;HSPB2;HSPB3;HSPB6;HSPB7;HSPB8 2 HSPB9 GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP HSPB1;HSPB2;HSPB3;HSPB6;HSPB7 1 HTT GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Retrograde transport along axons ARL8A;ARL8B;HAP1;HTT;MAP1LC3B;RILP;RUFY3 2 HUWE1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 HYPK GO:0006474 N-terminal protein amino acid acetylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|Modulator of NatA and NatE complexes NAA10;NAA15;NAA20;NAA25;NAA30 1 IBTK GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin, RCC1 ENC1;GAN;IPP;KBTBD2;KBTBD3 1 ILF2 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex AATF;IMP3;NOP56;UTP4 1 ILF3 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex AATF;IMP3;NOP56;UTP4 1 IMMT GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway CLEC16A;PARL;PGAM5;PINK1;PRKN 1 ING4 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other PRPF19;STUB1;UBE4A;UBOX5;WDSUB1 1 IPO4 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 IRF2BP2 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|IRF2 binding MID1;MID2;TRIM36;TRIM46;TRIM9 1 ISG20L2 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease AATF;IMP3;NOP56;UTP4 1 KAT2B GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|bromodomain, Acyl_CoA_acyltransferase KAT2B;PPARA;PPARG;TNFAIP3;ZFP91 1 KBTBD13 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KBTBD4 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCMF1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|noncatalytic subunit;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|idiosyncratic / noncatalytic|UBZ (Di19) ANAPC11;ANAPC2;CALM1;FANCL;KCMF1;SHARPIN;UBR4 2 KCTD10 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD11 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD20 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD21 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40 ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD5 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD6 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD7 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KCTD9 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KDELR1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 KDELR2 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 KDELR3 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 KDM2A GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 KDM2B GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 KEAP1 GO:1900407 regulation of cellular response to oxidative stress new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor regulator|Oxidative stress response PN regulation|Transcription factor regulator|Oxidative stress response|NFE2L2 modulator KEAP1 1 KLHL14 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KLHL31 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KLHL34 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KLHL42 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 KMT2A GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET PRPF19;STUB1;UBE4A;UBOX5;WDSUB1 1 KMT2B GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET PRPF19;STUB1;UBE4A;UBOX5;WDSUB1 1 KMT2C GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase MID1;MID2;TRIM36;TRIM46;TRIM9 1 KMT2D GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase MID1;MID2;TRIM36;TRIM46;TRIM9 1 LGALS3BP GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 LLPH GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 LLPH GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex AATF;IMP3;NOP56;UTP4 1 LMAN1 GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 LMAN1L GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 LMAN2 GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 LMAN2L GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 LMBR1L GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / transmembrane GID8;MAEA;RANBP10;RMND5A;RMND5B 1 LMNB1 GO:0044804 nucleophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Nucleophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Nucleophagy LMNB1 1 LRR1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR APPBP2;FEM1A;FEM1B;FEM1C;VHL 1 LRRC14 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR APPBP2;FEM1A;FEM1B;FEM1C;VHL 1 LRRC28 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|non-canonical|with LRR APPBP2;FEM1A;FEM1B;FEM1C;VHL 1 LRRC42 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR APPBP2;FEM1A;FEM1B;FEM1C;VHL 1 LRRK2 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 LRRK2 GO:0060590 ATPase regulator activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Regulator of the lysosomal v-ATPase proton pump ATP6AP1;ATP6AP2;LRRK2 1 LSG1 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 LTN1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 MAGEA11 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|MAGE IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2 1 MAN2C1 GO:0006517 protein deglycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates ENGASE;MAN2C1;NGLY1 1 MAN2C1 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 MAP1LC3B GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|ATG8 homolog ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3 3 MAP3K20 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 MAPK8IP1 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Miscellaneous function - movement of autophagosomes along microtubules ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3 2 MARCHF5 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy BNIP1;MARCHF5;RNF185;TANK;TBK1 1 MARCHF5 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway ANKZF1;FAF2;MARCHF5;USP30;VCP 1 MCM2 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 MCTS1 GO:0006415 translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation termination Translation|Cytosolic translation|Translation termination|tRNA, mRNA release ABCE1;EIF2D;ETF1;GSPT1;GSPT2 1 MDM4 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mdm|RanBP2-type ZNF;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Mdm|RanBP2-type ZnF ASB2;FBXW4;FBXW7;FBXW8;MID1;MID2;PML;TRIM36;TRIM46;TRIM9 2 MEFV GO:0160247 autophagy cargo adaptor activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Individual substrates CCDC50;MEFV 1 MEX3A GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3 MID1;MID2;TRIM36;TRIM46;TRIM9 1 MEX3B GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3 MID1;MID2;TRIM36;TRIM46;TRIM9 1 MEX3D GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3 MID1;MID2;TRIM36;TRIM46;TRIM9 1 MFN1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy CLEC16A;PARL;PGAM5;PINK1;PRKN 1 MIDN GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 1 MIEF1 GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Regulation of 28S-39S subunit association METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 MKRN1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 MKRN2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 MLEC GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone DAD1;DDOST;MAGT1;OSTC;RPN1 1 MMGT1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|EMC complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 MNAT1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other;Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / second enzymatic function|UIM ASB2;FBXW4;FBXW7;FBXW8;MID1;MID2;PML;TRIM36;TRIM46;TRIM9 2 MRE11 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / DNA binding GID8;MAEA;RANBP10;RMND5A;RMND5B 1 MRM1 GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 MSL1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|noncatalytic / other GID8;MAEA;RANBP10;RMND5A;RMND5B 1 MSL2 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|catalytic / RING GID8;MAEA;RANBP10;RMND5A;RMND5B 1 MT-RNR2 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Stabilizer of HSP90 binding of CMA substrates AMBRA1;GFAP;MT-RNR2;PSME1;TP53 1 MTMR14 GO:0046856 phosphatidylinositol dephosphorylation new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|Regulation of PI(3)P levels MTMR14;MTMR3;MTMR4;MTMR8;MTMR9 1 MTRES1 GO:0070126 mitochondrial translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Translation termination Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes MRPL58;MTRES1;MTRF1;MTRF1L;MTRFR 1 MVB12B GO:0000045 autophagosome assembly new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component TSG101;VPS28;VPS37A;VPS37B;VPS37C 1 MYDGF GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport;ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport COPA;COPB1;COPB2;COPE;COPG1;KDELR1;KDELR2;KDELR3;MYDGF 2 MYDGF GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|Receptor for KDEL-containing proteins for retrograde transport SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 MYO6 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1 2 N4BP1 GO:1990948 ubiquitin ligase inhibitor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor|ITCH inhibitor|UBA (N4BP1) N4BP1 1 NAA25 GO:0006474 N-terminal protein amino acid acetylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatB complex component NAA10;NAA15;NAA20;NAA25;NAA30 1 NAA30 GO:0006474 N-terminal protein amino acid acetylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component NAA10;NAA15;NAA20;NAA25;NAA30 1 NAA35 GO:0006474 N-terminal protein amino acid acetylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component NAA10;NAA15;NAA20;NAA25;NAA30 1 NAA38 GO:0006474 N-terminal protein amino acid acetylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component NAA10;NAA15;NAA20;NAA25;NAA30 1 NAA40 GO:0006474 N-terminal protein amino acid acetylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatD, sole component NAA10;NAA15;NAA20;NAA25;NAA30 1 NAP1L1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy BNIP1;MARCHF5;RNF185;TANK;TBK1 1 NAP1L2 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NAP1L3 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NAP1L4 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NAP1L5 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NASP GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NBN GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / BRCT GID8;MAEA;RANBP10;RMND5A;RMND5B 1 NCL GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NCLN GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 NCLN GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 NCOR1 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Derepresses transcription of CMA components NCOR1;NFATC1 1 NEMF GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 NFATC1 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Promotes transcription of LAMP2 NCOR1;NFATC1 1 NFKB2 GO:0006954 inflammatory response new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor|Inflammatory response PN regulation|Transcription factor|Inflammatory response|Transcription of xenobiotic response genes|NFkB complex component NFKB1;NFKB2;REL;RELA;RELB 1 NFXL1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX|transmembrane MID1;MID2;TRIM36;TRIM46;TRIM9 1 NGDN GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex BOP1;DDX27;PELP1;PES1;WDR12 1 NGLY1 GO:0006517 protein deglycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates ENGASE;MAN2C1;NGLY1 1 NGLY1 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|Deglycosylation of ERAD substrates DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 NKRF GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex BOP1;DDX27;PELP1;PES1;WDR12 1 NKRF GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex AATF;IMP3;NOP56;UTP4 1 NLN GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Intermembrane space protease ANKZF1;FAF2;MARCHF5;USP30;VCP 1 NLRX1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1 1 NOL10 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex BOP1;DDX27;PELP1;PES1;WDR12 1 NOMO1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 NOMO1 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 NOMO2 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 NOMO2 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 NOMO3 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 NOMO3 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 NOP53 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 NPLOC4 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitin recognition GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 NPM1 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NPM2 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NPM3 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 NSD2 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase MID1;MID2;TRIM36;TRIM46;TRIM9 1 NUFIP1 GO:0034517 ribophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ribophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Ribophagy NUFIP1 1 NUP160 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 NUP205 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 NUP210 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 NUP37 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 NUP43 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 NUP62CL GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 OAZ1 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|antizyme AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 1 ODF1 GO:0044183 protein folding chaperone new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|small HSP system|small HSP Cytonuclear proteostasis|Chaperone|small HSP system|small HSP HSPB1;HSPB2;HSPB3;HSPB6;HSPB7 1 OGT GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|O-GlcNAclyation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 OMA1 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease ANKZF1;FAF2;MARCHF5;USP30;VCP 1 OPTN GO:0035973 aggrephagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy MAP1S;NBR1;OPTN;SQSTM1;TOLLIP 1 OSBPL1A GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER ARL8A;ARL8B;MAP1LC3B;OSBPL1A;RILP;RUFY3;VAPA 2 OSTM1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other KAT2B;PPARA;PPARG;TNFAIP3;ZFP91 1 OTUB1 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated DUB DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 OTUD3 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 OXA1L GO:0015031 protein transport new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Protein transport Mitochondrial proteostasis|Protein transport|Inner membrane import|For assembly of inner membrane complexes TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7 1 P4HA1 GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 P4HA2 GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 P4HA3 GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 P4HB GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 PAAF1 GO:0043248 proteasome assembly new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone;Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|WD40 PAAF1;POMP;PSMD10;PSMD5;PSMD9;PSMG1;PSMG2;PSMG3;PSMG4 2 PABPC1 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC1 GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PABPC1L GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC1L GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PABPC1L2A GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC1L2A GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PABPC1L2B GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC1L2B GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PABPC3 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC3 GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PABPC4L GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC4L GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PABPC5 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 PABPC5 GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 PARK7 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Modulator of mitochondrial morphology-induced mitophagy CLEC16A;PARL;PGAM5;PINK1;PRKN 1 PARN GO:0006364 rRNA processing new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease EXOSC10;FCF1;NOB1;PARN;RMRP 1 PARN GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease AATF;IMP3;NOP56;UTP4 1 PCGF1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9 2 PCGF2 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9 2 PCGF6 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL;Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb BMI1;MID1;MID2;PCGF1;PCGF2;RING1;RNF2;TRIM36;TRIM46;TRIM9 2 PDF GO:0034982 mitochondrial protein processing new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Mitochondrial protein maturation Mitochondrial proteostasis|Mitochondrial protein maturation|Methionine deformylation IMMP1L;IMMP2L;METAP1D;MIPEP;XPNPEP3 1 PDLIM2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|BTRC specific IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2 1 PDZRN4 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 PELO GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 PELP1 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex BOP1;DDX27;PELP1;PES1;WDR12 1 PGGHG GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 PHF23 GO:0098792 xenophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Suppressor of intracellular pathogen ubiquitination LRSAM1;PHF23;RNF166 1 PHIP GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 PHLPP1 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization AMBRA1;GFAP;MT-RNR2;PSME1;TP53 1 PHRF1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 PICALM GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex regulator PICALM;STX7;STX8;VAMP3;VAMP7;VTI1B 2 PITHD1 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|PITH ECPAS;PITHD1;PSME4;PSMF1 1 PLBD1 GO:0120569 phospholipase activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal phospholipase PLA2G10;PLA2G15;PLA2G4E;PLA2G5;PLBD1 1 PLEKHM1 GO:0097352 autophagosome maturation new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges ATG8 and HOPS complex Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Recruitment of HOPS complex to autophagosome|Bridges ATG8 and HOPS complex PLEKHM1 1 PNO1 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 PPARA GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor KAT2B;PPARA;PPARG;TNFAIP3;ZFP91 1 PPARG GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor KAT2B;PPARA;PPARG;TNFAIP3;ZFP91 1 PPIB GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 PPIL2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C 2 PPIL6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C 2 PRORP GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 PSAP GO:0030290 sphingolipid activator protein activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|General activator of glycosphingolipid degradation Autophagy-Lysosome Pathway|Lysosomal catabolism|Lysosomal lipid catabolism|Lysosomal sphingomyelin/ceramide metabolism|General activator of glycosphingolipid degradation PSAP 1 PSME1 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28 PSME1;PSME2;PSME3 1 PSME1 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of interaction between substrate and lysosome-p53 AMBRA1;GFAP;MT-RNR2;PSME1;TP53 1 PSME2 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28 PSME1;PSME2;PSME3 1 PSME3 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28 PSME1;PSME2;PSME3 1 PSTK GO:0004812 aminoacyl-tRNA ligase activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation elongation|tRNA synthetase Translation|Cytosolic translation|Translation elongation|tRNA synthetase AARS1;CARS1;DARS1;EPRS1;FARSA 1 PTCD1 GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA chaperone METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 PTCD3 GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Translation initiation|assorted initiation factors Translation|Mitochondrial translation|Translation initiation|assorted initiation factors MTIF2;MTIF3;PTCD3 1 RAB11A GO:1904715 negative regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Promotes transport of LAMP2A to the lysosome BMAL1;RAB11A;RARA 1 RAB17 GO:0098792 xenophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy RAB17;RAB23 1 RAB23 GO:0098792 xenophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Xenophagy RAB17;RAB23 1 RAB26 GO:0160247 autophagy cargo adaptor activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Synaptophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Synaptophagy RAB26 1 RAB5IF GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 RAB5IF GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 RAB7B GO:0061724 lipophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Recruiting autophagy factors to lipid droplets ADRB2;AUP1;RAB7A;RAB7B;UBE2G2 1 RAB8B GO:0031201 SNARE complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Autophagosome-lysosome docking|Lysosome-autophagosome SNARE complex RAB8B;SNAP29;STX17;STX7;YKT6 1 RABGEF1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagosome formation for selective autophagy|Mitophagy CALCOCO2;RABGEF1 1 RAC1 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of LAMP2A multimerization AMBRA1;GFAP;MT-RNR2;PSME1;TP53 1 RACK1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 RACK1 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 RACK1 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex AATF;IMP3;NOP56;UTP4 1 RAD50 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / ATPase GID8;MAEA;RANBP10;RMND5A;RMND5B 1 RAE1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 RAE1 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S export adapter AATF;IMP3;NOP56;UTP4 1 RANBP2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases;Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type AIP;AIPL1;CWC27;FKBP1A;FKBP1B;FKBP3;NKTR;PPIA;PPIAL4A;PPIAL4C 2 RAPSN GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|TPR MID1;MID2;TRIM36;TRIM46;TRIM9 1 RARA GO:1904715 negative regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Extralysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Represses transcription of CMA components BMAL1;RAB11A;RARA 1 RBBP4 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 RBBP7 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 RBBP8 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|DNA endonuclease GID8;MAEA;RANBP10;RMND5A;RMND5B 1 RBM10 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF RBM10;RBM44;RBM5;RBM6;ZRANB2 1 RBM44 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|UBA-like (other) RBM10;RBM44;RBM5;RBM6;ZRANB2 1 RBM6 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF RBM10;RBM44;RBM5;RBM6;ZRANB2 1 RCBTB1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|RCC1 ENC1;GAN;IPP;KBTBD2;KBTBD3 1 RCBTB2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|RCC1 ENC1;GAN;IPP;KBTBD2;KBTBD3 1 RCC1 GO:0006913 nucleocytoplasmic transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport|Nuclear transport, RAN system Nuclear proteostasis|Protein transport|Nuclear transport, RAN system RAN;RANBP2;RANGAP1;RGPD1;RGPD2 1 RCC1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear transport, RAN system GLE1;NUP214;NUP88;RAE1;RANBP2 1 RCC1L GO:0006913 nucleocytoplasmic transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport|Nuclear transport, RAN system Nuclear proteostasis|Protein transport|Nuclear transport, RAN system RAN;RANBP2;RANGAP1;RGPD1;RGPD2 1 RCC1L GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear transport, RAN system GLE1;NUP214;NUP88;RAE1;RANBP2 1 RETREG2 GO:0061709 reticulophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|ERphagy RETREG1;RETREG2;RETREG3;RTN3;SEC62 1 REXO2 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease AATF;IMP3;NOP56;UTP4 1 RHBDL3 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD ER proteostasis|Organelle-specific protein degradation|ER associated degradation|VCP system for retrotranslocation in ERAD|Intramembrane protease, cleaves unstable membrane proteins, transfers to ERAD DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBQLN1;UBQLN2;UBXN4;UBXN8;VCP 2 RHOBTB1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase ENC1;GAN;IPP;KBTBD2;KBTBD3 1 RHOBTB3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase ENC1;GAN;IPP;KBTBD2;KBTBD3 1 RICTOR GO:1904715 negative regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy inhibitor|Modulator of LAMP2A multimerization AKT1;CTSA;RICTOR 1 RILP GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|Recruitment of dynein-dynactin motor complex ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3 3 RNF123 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex|catalytic / RING, SPRY GID8;MAEA;RANBP10;RMND5A;RMND5B 1 RNF14 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 RNF166 GO:0098792 xenophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Xenophagy|Catalyzes K33-linked ubiquitination of p62 LRSAM1;PHF23;RNF166 1 RNF17 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 RNF170 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|catalytic / RING, transmembrane GID8;MAEA;RANBP10;RMND5A;RMND5B 1 RNF170 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated RING E3 ligase DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 RNF185 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|catalytic / RING, transmembrane GID8;MAEA;RANBP10;RMND5A;RMND5B 1 RNF185 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy BNIP1;MARCHF5;RNF185;TANK;TBK1 1 RNF207 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 RNF212 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 RNF222 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain MID1;MID2;TRIM36;TRIM46;TRIM9 1 RNF24 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|Golgi MID1;MID2;TRIM36;TRIM46;TRIM9 1 RNF25 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 RNF32 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 RNF41 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway CLEC16A;PARL;PGAM5;PINK1;PRKN 1 RNF5 GO:2000785 regulation of autophagosome assembly new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Modulation of ATG4 activity Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|ATG8 homolog processing, upstream|Preparation of ATG8 homologs for lipidation|Modulation of ATG4 activity RNF5 1 RPF2 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 RPUSD4 GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 RRP12 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 RRP12 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex AATF;IMP3;NOP56;UTP4 1 RRP8 GO:0000154 rRNA modification new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification BUD23;EMG1;LOC124902573;NAT10;TSR3 1 RRP8 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification AATF;IMP3;NOP56;UTP4 1 RUBCN GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component BECN1;PIK3C3;PIK3R4;SH3GLB1;UVRAG 1 RUBCNL GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Class 3 PI3K complex 2, direct|Class 3 PI3K complex 2 component BECN1;PIK3C3;PIK3R4;SH3GLB1;UVRAG 1 RUFY1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 RUFY3 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4 3 RUFY4 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging ARL8A;ARL8B;MAP1LC3B;RILP;RUFY3;RUFY4 3 SAMTOR GO:1990130 GATOR1 complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex modulator Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR1 complex modulator SAMTOR 1 SANBR GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other ENC1;GAN;IPP;KBTBD2;KBTBD3 1 SAR1B GO:0061700 GATOR2 complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|GATOR2 complex modulator SAR1B;SESN1;SESN2;SESN3 1 SART1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other KAT2B;PPARA;PPARG;TNFAIP3;ZFP91 1 SBDS GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 SCAF11 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 SCYL1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SCYL3 GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi COPA;COPB1;COPB2;COPE;COPG1 1 SCYL3 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER-Golgi trafficking|Retrograde transport|COPI scaffolding in the Golgi SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SDE2 GO:0006281 DNA repair new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair SDE2 1 SEC11A GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER signal peptidase SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SEC11C GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER signal peptidase SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SECISBP2 GO:0003746 translation elongation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation elongation|assorted elongation factors Translation|Cytosolic translation|Translation elongation|assorted elongation factors EEF1A1;EEF1A2;EEF2;EEF2K;EEF2KMT 1 SEH1L GO:0015031 protein transport new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Protein transport Nuclear proteostasis|Protein transport|Nuclear pore complex GLE1;NUP214;NUP88;RAE1;RANBP2 1 SELENOF GO:0006487 protein N-linked glycosylation new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Glycoproteostasis|N-glycosylation system ER proteostasis|Glycoproteostasis|N-glycosylation system|N-glycan processing|Re-glucosylation DAD1;DDOST;MAGT1;OSTC;RPN1 1 SEPSECS GO:0004812 aminoacyl-tRNA ligase activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation elongation|tRNA synthetase Translation|Cytosolic translation|Translation elongation|tRNA synthetase AARS1;CARS1;DARS1;EPRS1;FARSA 1 SERP1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|SEC61 channel accessory protein SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SERP2 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|SEC61 channel accessory protein SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SERPINH1 GO:0032964 collagen biosynthetic process new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding ER proteostasis|Maturation and folding of specific substrates|ER collagen processing and folding P4HA1;P4HA2;P4HA3;P4HB;PLOD1 1 SET GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 SGTA GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SGTB GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SHKBP1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40 ENC1;GAN;IPP;KBTBD2;KBTBD3 1 SIAH1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway CLEC16A;PARL;PGAM5;PINK1;PRKN 1 SMN1 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM RBM10;RBM44;RBM5;RBM6;ZRANB2 1 SMN2 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM RBM10;RBM44;RBM5;RBM6;ZRANB2 1 SNCAIP GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway CLEC16A;PARL;PGAM5;PINK1;PRKN 1 SNORD3A GO:0032040 small-subunit processome new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex HEATR1;UTP15;UTP4;WDR43;WDR75 1 SPAG1 GO:0031072 heat shock protein binding new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and RPAP3-like C-terminal domain containing DNAAF4;DNAJC7;SMYD4;TTC12;TTC4 1 SPCS1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER signal peptidase SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SPCS2 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER signal peptidase SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SPCS3 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|ER signal peptidase SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SPNS1 GO:0007041 lysosomal transport new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products SPNS1 1 SPOP GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 SPOPL GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH ENC1;GAN;IPP;KBTBD2;KBTBD3 1 SRP19 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Signal recognition particle component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SRP68 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Signal recognition particle component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SRP72 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Signal recognition particle component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SRP9 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Signal recognition particle component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SRPRB GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|SRP receptor subunit SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 SSRP1 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 ST13 GO:0061684 chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8 1 ST13 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection HSP90AA1;HSP90AB1;ST13;STIP1;STUB1 1 STIP1 GO:0061684 chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection CLU;DNAJB1;HSP90AA1;HSP90AB1;HSPA8 1 STIP1 GO:0061738 late endosomal microautophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy Autophagy-Lysosome Pathway|Microautophagy|Endosomal microautophagy DNAJB1;HSPA8;STIP1 1 STIP1 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Effectors of chaperone-mediated autophagy|Substrate selection HSP90AA1;HSP90AB1;ST13;STIP1;STUB1 1 STUB1 GO:0035973 aggrephagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Chaperone assisted selective autophagy|CASA complex component BAG3;HSPA8;HSPB8;STUB1 1 STX7 GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex STX7;STX8;VAMP3;VAMP7;VTI1B 2 STX8 GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex STX7;STX8;VAMP3;VAMP7;VTI1B 2 SUPT6H GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 TANK GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Autophagy receptor regulation|Mitophagy BNIP1;MARCHF5;RNF185;TANK;TBK1 1 TAX1BP1 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1 1 TAX1BP1 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1 2 TAX1BP1 GO:0098792 xenophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Xenophagy CALCOCO2;OPTN;SQSTM1;TAX1BP1;TRIM5 1 TBC1D15 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1 1 TBC1D17 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1 1 TBL3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|WD40 AHR;ARNT;COP1;DCAF13;DCAF7 1 TCF25 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 TELO2 GO:0031931 TORC1 complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, direct|mTORC1 complex component AKT1S1;DEPTOR;MLST8;MTOR;RPTOR 1 TELO2 GO:0031932 TORC2 complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component Autophagy-Lysosome Pathway|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Insulin signaling pathway|AKT1 activator, mTORC2 complex component DEPTOR;MAPKAP1;MLST8;MTOR;RICTOR 1 TEX10 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex BOP1;DDX27;PELP1;PES1;WDR12 1 TIMM29 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Protein transport Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7 1 TMA16 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 TMCO1 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 TMCO1 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|GEL complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 TMEM106B GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 TMEM147 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 TMEM147 GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|BOS complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 TMEM175 GO:0007042 lysosomal lumen acidification new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification ATP6V0A1;ATP6V0A2;ATP6V0A4;ATP6V0B;TCIRG1 1 TMEM183A GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 TMEM183BP GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane FBXL2;FBXL3;FBXL4;FBXL5;SKP2 1 TMEM259 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane GID8;MAEA;RANBP10;RMND5A;RMND5B 1 TMUB1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL GID8;MAEA;RANBP10;RMND5A;RMND5B 1 TMUB2 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL GID8;MAEA;RANBP10;RMND5A;RMND5B 1 TMX2 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 TMX4 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 TOLLIP GO:0035973 aggrephagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Aggrephagy MAP1S;NBR1;OPTN;SQSTM1;TOLLIP 1 TOM1 GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Movement of autophagosomes along actin ARL8A;ARL8B;CALCOCO2;MAP1LC3B;MYO6;RILP;RUFY3;TAX1BP1;TOM1 2 TOMM20L GO:0045040 protein insertion into mitochondrial outer membrane new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Protein transport|Outer membrane import Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7 1 TOMM5 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Protein transport Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7 1 TOMM6 GO:0015031 protein transport new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Protein transport Mitochondrial proteostasis|Protein transport|Outer membrane import|TOMM complex TOMM20;TOMM20L;TOMM5;TOMM6;TOMM7 1 TONSL GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 TOPBP1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|BRCT GID8;MAEA;RANBP10;RMND5A;RMND5B 1 TOR1AIP2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 TP53 GO:1904716 positive regulation of chaperone-mediated autophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer Autophagy-Lysosome Pathway|Chaperone-mediated autophagy|Lysosomal modulator of chaperone-mediated autophagy|Chaperone-mediated autophagy enhancer|Modulator of HSPA8 role in assembly of LAMP2A AMBRA1;GFAP;MT-RNR2;PSME1;TP53 1 TRIB3 GO:0006954 inflammatory response new_to_goa ok_for_propagation_to_go pn_regulation.yaml PN regulation|Transcription factor regulator|Inflammatory response PN regulation|Transcription factor regulator|Inflammatory response|NFkB modulator TRIB3 1 TRIM13 GO:0061709 reticulophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy;Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|ERphagy|Ubiquitination of ER proteins DDRGK1;TRIM13;UBA5;UFC1;UFL1 2 TRIM16 GO:0160247 autophagy cargo adaptor activity new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Lysophagy CALCOCO2;TRIM16 1 TRIM16L GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY & folded central helix MID1;MID2;TRIM36;TRIM46;TRIM9 1 TRIM29 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD MID1;MID2;TRIM36;TRIM46;TRIM9 1 TRIM46 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY MID1;MID2;TRIM36;TRIM46;TRIM9 1 TRIM66 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD MID1;MID2;TRIM36;TRIM46;TRIM9 1 TRIM67 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY MID1;MID2;TRIM36;TRIM46;TRIM9 1 TRIP4 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 TRMT10C GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 TRMT2B GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 TRMT61B GO:0000154 rRNA modification new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation MRM1;MRM2;MRM3;RPUSD4;TRMT61B 1 TRMT61B GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation METTL15;MTERF4;NSUN4;TFB1M;TRMT2B 1 TSR1 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 TSR2 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 TSR3 GO:0030688 preribosome, small subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex BUD23;BYSL;EIF5B;LTV1;NOB1 1 TUFM GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy CALCOCO2;FUNDC1;OPTN;SQSTM1;TAX1BP1 1 TXNDC11 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 TXNDC12 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 TXNDC16 GO:0003756 protein disulfide isomerase activity new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Folding enzyme|Protein disulfide isomerases ER proteostasis|Folding enzyme|Protein disulfide isomerases AGR2;AGR3;CASQ1;CASQ2;DNAJC10 1 UBA5 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UBAC2 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / UBA, transmembrane GID8;MAEA;RANBP10;RMND5A;RMND5B 1 UBAP1 GO:0000045 autophagosome assembly new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component TSG101;VPS28;VPS37A;VPS37B;VPS37C 1 UBAP2 GO:0006281 DNA repair new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2) ABRAXAS1;ABRAXAS2;BABAM2;GCNA;POLH 1 UBAP2L GO:0006281 DNA repair new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2) ABRAXAS1;ABRAXAS2;BABAM2;GCNA;POLH 1 UBE2D1 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 UBE2D2 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins CLEC16A;PARL;PGAM5;PINK1;PRKN 1 UBE2D3 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins CLEC16A;PARL;PGAM5;PINK1;PRKN 1 UBE2G1 GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 UBE2G2 GO:0061724 lipophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Ubiquitination of lipid droplet surface proteins ADRB2;AUP1;RAB7A;RAB7B;UBE2G2 1 UBE2K GO:0036503 ERAD pathway new_to_goa exact;ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Organelle-specific protein degradation|ER associated degradation;ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates ER proteostasis|Organelle-specific protein degradation|ER associated degradation|Cytosolic handling of ERAD substrates|ERAD-associated E2 conjugating enzyme DERL1;DERL2;DERL3;HERPUD1;SYVN1;UBE2D1;UBE2G1;UBE2G2;UBE2J2;UBE2K 2 UBE2L3 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins CLEC16A;PARL;PGAM5;PINK1;PRKN 1 UBE2N GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Ubiquitination of mitochondrial proteins CLEC16A;PARL;PGAM5;PINK1;PRKN 1 UBL4A GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|GET pathway component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 UBN1 GO:0140713 histone chaperone activity new_to_goa ok_for_propagation_to_go nuclear_proteostasis.yaml Nuclear proteostasis|Chaperone|Histone chaperone Nuclear proteostasis|Chaperone|Histone chaperone ASF1A;ASF1B;CHAF1A;NPM1 1 UBQLN1 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting ANKZF1;FAF2;MARCHF5;USP30;VCP 1 UBQLN1 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B 2 UBQLN2 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting ANKZF1;FAF2;MARCHF5;USP30;VCP 1 UBQLN2 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B 2 UBQLN3 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting ANKZF1;FAF2;MARCHF5;USP30;VCP 1 UBQLN3 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B 2 UBQLN4 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting ANKZF1;FAF2;MARCHF5;USP30;VCP 1 UBQLN4 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B 2 UBQLNL GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|Degradation of mitochondrial membrane proteins that fail targeting ANKZF1;FAF2;MARCHF5;USP30;VCP 1 UBQLNL GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 1 UBR4 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|catalytic subunit CALM1;KCMF1;UBR4 1 UFC1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UFD1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|VCP system for RQC GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UFL1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UFM1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UFSP1 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UFSP2 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|UFMylation GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 UFSP2 GO:0071569 protein ufmylation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC|UFMylation Translation|Cytosolic translation|Ribosome-associated QC|UFMylation DDRGK1;UBA5;UFC1;UFL1;UFM1 1 UIMC1 GO:0000151 ubiquitin ligase complex new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding GID8;MAEA;RANBP10;RMND5A;RMND5B 1 UMAD1 GO:0000045 autophagosome assembly new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component TSG101;VPS28;VPS37A;VPS37B;VPS37C 1 UMAD1 GO:0000813 ESCRT I complex new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Sealing of autophagophore membrane|ESCRT-I complex component TSG101;VPS28;VPS37A;VPS37B;VPS37C 1 UNK GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF MID1;MID2;TRIM36;TRIM46;TRIM9 1 UNKL GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF MID1;MID2;TRIM36;TRIM46;TRIM9 1 UPF2 GO:0006415 translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation termination Translation|Cytosolic translation|Translation termination|Modulation of termination ABCE1;EIF2D;ETF1;GSPT1;GSPT2 1 UPF3A GO:0006415 translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation termination Translation|Cytosolic translation|Translation termination|Modulation of termination ABCE1;EIF2D;ETF1;GSPT1;GSPT2 1 UPF3B GO:0006415 translational termination new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation termination Translation|Cytosolic translation|Translation termination|Modulation of termination ABCE1;EIF2D;ETF1;GSPT1;GSPT2 1 USP10 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 USP15 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins CLEC16A;PARL;PGAM5;PINK1;PRKN 1 USP21 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 USP30 GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway ANKZF1;FAF2;MARCHF5;USP30;VCP 1 USP35 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|Deubiquitination of mitochondrial proteins CLEC16A;PARL;PGAM5;PINK1;PRKN 1 USP8 GO:0000423 mitophagy new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway CLEC16A;PARL;PGAM5;PINK1;PRKN 1 VAMP2 GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex STX7;STX8;VAMP3;VAMP7;VTI1B 2 VAMP3 GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex STX7;STX8;VAMP3;VAMP7;VTI1B 2 VAMP7 GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex STX7;STX8;VAMP3;VAMP7;VTI1B 2 VAPA GO:0061906 autophagosome localization new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome;Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER Autophagy-Lysosome Pathway|Autophagosome closure maturation and lysosome fusion|Localization of the autophagosome|Recruitment of autophagosome to vicinity of ER ARL8A;ARL8B;MAP1LC3B;OSBPL1A;RILP;RUFY3;VAPA 2 VCP GO:0003743 translation initiation factor activity new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation|assorted initiation factors Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF1;EIF1AX;EIF1AY;EIF4B;EIF4H 1 VCP GO:0006413 translational initiation new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Translation initiation Translation|Cytosolic translation|Translation initiation|assorted initiation factors EIF2B1;EIF2S1;EIF2S2;EIF2S3;EIF2S3B 1 VCP GO:0035694 mitochondrial protein catabolic process new_to_goa ok_for_propagation_to_go mitochondrial_proteostasis.yaml Mitochondrial proteostasis|Organelle-specific protein degradation Mitochondrial proteostasis|Organelle-specific protein degradation|mitoTAD pathway ANKZF1;FAF2;MARCHF5;USP30;VCP 1 VPS41 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40 MID1;MID2;TRIM36;TRIM46;TRIM9 1 VPS8 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40 MID1;MID2;TRIM36;TRIM46;TRIM9 1 VTI1B GO:1905686 positive regulation of plasma membrane repair new_to_goa ok_for_propagation_to_go autophagy_lysosome_pathway.yaml Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input;Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG16L1-positive plasma membrane input|Autophagophore-vesicle SNARE complex STX7;STX8;VAMP3;VAMP7;VTI1B 2 WDR18 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex BOP1;DDX27;PELP1;PES1;WDR12 1 WDR83OS GO:0015031 protein transport new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component SEC61A1;SEC61A2;SEC61B;SEC61G;SEC62 1 WDR83OS GO:0044743 protein transmembrane import into intracellular organelle new_to_goa ok_for_propagation_to_go er_proteostasis.yaml ER proteostasis|Protein transport|Transmembrane protein import ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component NCLN;NOMO1;RAB5IF;TMCO1;TMEM147 1 WDTC1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go chaperone_systems.yaml Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase LONRF3;STUB1;TTC3;WDTC1 1 WDTC1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|TPR BRWD1;BRWD3;DCAF1;DCAF6;PHIP 1 XRN2 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex BOP1;DDX27;PELP1;PES1;WDR12 1 YBEY GO:0061668 mitochondrial ribosome assembly new_to_goa ok_for_propagation_to_go translation.yaml Translation|Mitochondrial translation|Mitoribosome biogenesis factor;Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly METTL15;MTERF4;NSUN4;TFB1M;TRMT2B;YBEY 2 YPEL1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2 1 YPEL2 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2 1 YPEL3 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2 1 YPEL4 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific IFI27;MAGEA11;PDLIM2;YPEL1;YPEL2 1 ZER1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZER1 group / Armadillo-like ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8 1 ZFAND2A GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UBZ;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|UBZ (ZFAND2A/B) AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B 2 ZFAND2B GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UIM;Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor|with AN1|UIM, UBZ (ZFAND2A/B) AKIRIN1;AKIRIN2;ZFAND1;ZFAND2A;ZFAND2B 2 ZFAND5 GO:0070628 proteasome binding new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|A20;Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|A20 ZnF AKIRIN1;AKIRIN2;RAD23A;RAD23B;UBQLN1;UBQLN2;UBQLN3;ZFAND1;ZFAND2A;ZFAND2B 2 ZFP42 GO:0006364 rRNA processing new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease REXO2;ZFP42 1 ZFP42 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease AATF;IMP3;NOP56;UTP4 1 ZFPL1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 ZFTRAF1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|other MID1;MID2;TRIM36;TRIM46;TRIM9 1 ZNF593 GO:0030687 preribosome, large subunit precursor new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex BOP1;DDX27;PELP1;PES1;WDR12 1 ZNF593 GO:0042254 ribosome biogenesis new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome biogenesis factor Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex AATF;IMP3;NOP56;UTP4 1 ZNF598 GO:0006515 protein quality control for misfolded or incompletely synthesized proteins new_to_goa ok_for_propagation_to_go translation.yaml Translation|Cytosolic translation|Ribosome-associated QC Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue GTPBP1;GTPBP2;HBS1L;PELO;RACK1 1 ZNFX1 GO:0061630 ubiquitin protein ligase activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ|RNA helicase RNF213;ZNFX1 1 ZRANB2 GO:0048024 regulation of mRNA splicing, via spliceosome new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF RBM10;RBM44;RBM5;RBM6;ZRANB2 1 ZSWIM4 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8 1 ZSWIM5 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8 1 ZSWIM6 GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM ZER1;ZSWIM4;ZSWIM5;ZSWIM6;ZSWIM8 1 ZYG11A GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like APPBP2;FEM1A;FEM1B;FEM1C;VHL 1 ZYG11B GO:1990756 ubiquitin-like ligase-substrate adaptor activity new_to_goa ok_for_propagation_to_go ubiquitin_proteasome_system.yaml Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like, LRR APPBP2;FEM1A;FEM1B;FEM1C;VHL 1