---
pmid: '22549728'
title: PRORP proteins support RNase P activity in both organelles and the nucleus
  in Arabidopsis.
authors:
- Gutmann B
- Gobert A
- Giegé P
journal: Genes Dev
year: '2012'
full_text_available: false
pmcid: PMC3360558
doi: 10.1101/gad.189514.112
pubmed_publication_types:
- Journal Article
- Research Support, Non-U.S. Gov't
publication_type: PRIMARY_RESEARCH
---

# PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis.
**Authors:** Gutmann B, Gobert A, Giegé P
**Journal:** Genes Dev (2012)
**DOI:** [10.1101/gad.189514.112](https://doi.org/10.1101/gad.189514.112)
**PMC:** [PMC3360558](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360558/)

## Abstract

1. Genes Dev. 2012 May 15;26(10):1022-7. doi: 10.1101/gad.189514.112. Epub 2012
May  1.

PRORP proteins support RNase P activity in both organelles and the nucleus in
Arabidopsis.

Gutmann B(1), Gobert A, Giegé P.

Author information:
(1)Institut de Biologie moléculaire des plantes du CNRS, University of
Strasbourg, 67084 Strasbourg, France.

Comment in
    Genes Dev. 2012 May 15;26(10):1005-9. doi: 10.1101/gad.193581.112.

RNase P is an essential enzyme that cleaves the 5' leader sequence of tRNA
precursors. RNase Ps were believed until now to occur universally as
ribonucleoproteins in organisms performing RNase P activity. Here we find that
protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support
RNase P activity in vivo in both organelles and the nucleus in Arabidopsis.
Beyond tRNA, PRORP proteins are involved in the maturation of small nucleolar
RNA (snoRNA) and mRNA. Finally, ribonucleoprotein RNase MRP is not involved in
tRNA maturation in plants. Altogether, our results indicate that
ribonucleoprotein enzymes have been entirely replaced by proteins for RNase P
activity in plants.

DOI: 10.1101/gad.189514.112
PMCID: PMC3360558
PMID: 22549728 [Indexed for MEDLINE]