---
pmid: '8510165'
title: The CUB domain. A widespread module in developmentally regulated proteins.
authors:
- Bork P
- Beckmann G
journal: J Mol Biol
year: '1993'
full_text_available: false
doi: 10.1006/jmbi.1993.1305
pubmed_publication_types:
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
publication_type: PRIMARY_RESEARCH
---

# The CUB domain. A widespread module in developmentally regulated proteins.
**Authors:** Bork P, Beckmann G
**Journal:** J Mol Biol (1993)
**DOI:** [10.1006/jmbi.1993.1305](https://doi.org/10.1006/jmbi.1993.1305)

## Abstract

1. J Mol Biol. 1993 May 20;231(2):539-45. doi: 10.1006/jmbi.1993.1305.

The CUB domain. A widespread module in developmentally regulated proteins.

Bork P(1), Beckmann G.

Author information:
(1)EMBL, Heidelberg, Germany.

Sequence analysis has revealed the presence of 31 copies of an extracellular
domain, here called CUB, in 16 functionally diverse proteins such as the
dorso-ventral patterning protein tolloid, bone morphogenetic protein 1, a family
of spermadhesins, complement subcomponents Cls/Clr and the neuronal recognition
molecule A5. Most of them are known to be involved in developmental processes.
Our analysis of this new family includes the identification of seven previously
undescribed members, the characterization of conserved features and a topology
prediction of this approximately 110 residue spanning domain, which suggests an
antiparallel beta-barrel similar to those in immunoglobulins.

DOI: 10.1006/jmbi.1993.1305
PMID: 8510165 [Indexed for MEDLINE]