---
pmid: '9670003'
title: PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes
  mellitus.
authors:
- Condorelli G
- Vigliotta G
- Iavarone C
- Caruso M
- Tocchetti CG
- Andreozzi F
- Cafieri A
- Tecce MF
- Formisano P
- Beguinot L
- Beguinot F
journal: EMBO J
year: '1998'
full_text_available: false
pmcid: PMC1170721
doi: 10.1093/emboj/17.14.3858
pubmed_publication_types:
- Journal Article
- Research Support, Non-U.S. Gov't
publication_type: PRIMARY_RESEARCH
---

# PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.
**Authors:** Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F
**Journal:** EMBO J (1998)
**DOI:** [10.1093/emboj/17.14.3858](https://doi.org/10.1093/emboj/17.14.3858)
**PMC:** [PMC1170721](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170721/)

## Abstract

1. EMBO J. 1998 Jul 15;17(14):3858-66. doi: 10.1093/emboj/17.14.3858.

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2
diabetes mellitus.

Condorelli G(1), Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F,
Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F.

Author information:
(1)Dipartimento di Biologia e Patologia Cellulare e Molecolare and Centro di
Endocrinologia ed Oncologia Sperimentale del C.N.R., Federico II University of
Naples, Naples, Italy.

We have used differential display to identify genes whose expression is altered
in type 2 diabetes thus contributing to its pathogenesis. One mRNA is
overexpressed in fibroblasts from type 2 diabetics compared with non-diabetic
individuals, as well as in skeletal muscle and adipose tissues, two major sites
of insulin resistance in type 2 diabetes. The levels of the protein encoded by
this mRNA are also elevated in type 2 diabetic tissues; thus, we named it PED
for phosphoprotein enriched in diabetes. PED cloning shows that it encodes a 15
kDa phosphoprotein identical to the protein kinase C (PKC) substrate PEA-15. The
PED gene maps on human chromosome 1q21-22. Transfection of PED/PEA-15 in
differentiating L6 skeletal muscle cells increases the content of Glut1
transporters on the plasma membrane and inhibits insulin-stimulated glucose
transport and cell-surface recruitment of Glut4, the major insulin-sensitive
glucose transporter. These effects of PED overexpression are reversed by
blocking PKC activity. Overexpression of the PED/PEA-15 gene may contribute to
insulin resistance in glucose uptake in type 2 diabetes.

DOI: 10.1093/emboj/17.14.3858
PMCID: PMC1170721
PMID: 9670003 [Indexed for MEDLINE]