View original ARBA rule on UniProt
Assigns the catalytic activity alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate (RHEA:16249, EC 5.1.3.15) to proteins matching three InterPro entries together: IPR025532 Glucose-6-phosphate 1-epimerase, IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase and IPR011013 Galactose mutarotase-like domain superfamily.
Condition-set counts describe the sets recorded in this review, which may omit the full rule.
No domain overlap table is shown: the cached overlap analysis for this version of the review is not available.
Run just analyze-rule ARBA00001096 and re-render to add it.
The single condition set was examined. The rule annotates 9,242 TrEMBL entries. The most specific condition, the family IPR025532, is nested in the other two, so the conjunction selects the same proteins as IPR025532 alone. All five Swiss-Prot members carry EC 5.1.3.15, one from a published assay and four by similarity to it.
The rule fires on a family signature named for the activity, and every reviewed member has that activity in UniProt. The two broader conditions are redundant but harmless.
matched_protein_count is the TrEMBL count UniProt reports for the rule. Q03161 has experimental evidence (PubMed:16857670); the other four have the activity by similarity (ECO:0000250).
UniProtKB query, November 2026: (xref:interpro-IPR025532) matches 9,248 entries; 1 of them lacks IPR008183 and none lacks IPR011013, so the two broader conditions exclude almost nothing. Five Swiss-Prot entries match all three conditions and all five carry EC 5.1.3.15: Q03161 (YMY9_YEAST) with experimental evidence (ECO:0000269, PubMed:16857670); P39173, Q8ZPV9, P44160 and Q40784 by similarity to Q03161 (ECO:0000250).
IPR008183 and IPR011013 add nothing to IPR025532: of 9,248 UniProtKB entries with IPR025532, one lacks IPR008183 and none lacks IPR011013 (UniProtKB queries, November 2026). The rule could be reduced to IPR025532 without changing its output materially.
UniProt record Q03161 (YMY9_YEAST): catalytic activity RHEA:16249, EC 5.1.3.15, evidence ECO:0000269 PubMed:16857670. The other four Swiss-Prot members are annotated by similarity to Q03161.
id: ARBA00001096
description: 'Assigns the catalytic activity alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate
(RHEA:16249, EC 5.1.3.15) to proteins matching three InterPro entries together: IPR025532 Glucose-6-phosphate
1-epimerase, IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase and IPR011013 Galactose mutarotase-like
domain superfamily.'
status: COMPLETE
rule_type: ARBA
rule:
rule_id: ARBA00001096
condition_sets:
- number: 1
conditions:
- condition_type: INTERPRO
value: IPR008183
curie: InterPro:IPR008183
label: Aldose 1-/Glucose-6-phosphate 1-epimerase
interpro_type: FAMILY
negated: false
- condition_type: INTERPRO
value: IPR011013
curie: InterPro:IPR011013
label: Galactose mutarotase-like domain superfamily
interpro_type: HOMOLOGOUS_SUPERFAMILY
negated: false
- condition_type: INTERPRO
value: IPR025532
curie: InterPro:IPR025532
label: Glucose-6-phosphate 1-epimerase
interpro_type: FAMILY
negated: false
notes: 'UniProtKB query, November 2026: (xref:interpro-IPR025532) matches 9,248 entries; 1 of them
lacks IPR008183 and none lacks IPR011013, so the two broader conditions exclude almost nothing.
Five Swiss-Prot entries match all three conditions and all five carry EC 5.1.3.15: Q03161 (YMY9_YEAST)
with experimental evidence (ECO:0000269, PubMed:16857670); P39173, Q8ZPV9, P44160 and Q40784 by
similarity to Q03161 (ECO:0000250).'
pairwise_overlap:
- condition_a: IPR008183
condition_b: IPR011013
protein_database: SWISSPROT
count_a: 31
count_b: 397
intersection_count: 31
a_minus_b_count: 0
b_minus_a_count: 366
jaccard_similarity: 0.07808564231738035
containment_a_in_b: 1.0
containment_b_in_a: 0.07808564231738035
interpretation: SUBSET
- condition_a: IPR008183
condition_b: IPR025532
protein_database: SWISSPROT
count_a: 31
count_b: 5
intersection_count: 5
a_minus_b_count: 26
b_minus_a_count: 0
jaccard_similarity: 0.16129032258064516
containment_a_in_b: 0.16129032258064516
containment_b_in_a: 1.0
interpretation: SUBSET
- condition_a: IPR011013
condition_b: IPR025532
protein_database: SWISSPROT
count_a: 397
count_b: 5
intersection_count: 5
a_minus_b_count: 392
b_minus_a_count: 0
jaccard_similarity: 0.012594458438287154
containment_a_in_b: 0.012594458438287154
containment_b_in_a: 1.0
interpretation: SUBSET
catalytic_activity_annotations:
- reaction_name: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate
rhea_id: RHEA:16249
ec_number: 5.1.3.15
entries:
- id: IPR008183
type: INTERPRO
label: Aldose 1-/Glucose-6-phosphate 1-epimerase
appears_in_condition_sets:
- 1
protein_count: 31
related_entries:
- relationship: PREDICTS
target_id: IPR011013
containment: 1.0
jaccard_similarity: 0.078
intersection_count: 31
exclusive_count: 0
- relationship: PREDICTED_BY
target_id: IPR025532
containment: 1.0
jaccard_similarity: 0.161
intersection_count: 5
exclusive_count: 0
- id: IPR011013
type: INTERPRO
label: Galactose mutarotase-like domain superfamily
appears_in_condition_sets:
- 1
protein_count: 397
related_entries:
- relationship: PREDICTED_BY
target_id: IPR008183
containment: 0.078
jaccard_similarity: 0.078
intersection_count: 31
exclusive_count: 366
- relationship: PREDICTED_BY
target_id: IPR025532
containment: 1.0
jaccard_similarity: 0.013
intersection_count: 5
exclusive_count: 0
- id: IPR025532
type: INTERPRO
label: Glucose-6-phosphate 1-epimerase
appears_in_condition_sets:
- 1
protein_count: 5
related_entries:
- relationship: PREDICTS
target_id: IPR008183
containment: 0.161
jaccard_similarity: 0.161
intersection_count: 5
exclusive_count: 26
- relationship: PREDICTS
target_id: IPR011013
containment: 0.013
jaccard_similarity: 0.013
intersection_count: 5
exclusive_count: 392
reviewed_protein_count: 0
unreviewed_protein_count: 9242
created_date: '2020-05-12'
modified_date: '2020-05-12'
retrieved_date: '2026-11-09'
source_condition_set_count: 1
review_summary: The single condition set was examined. The rule annotates 9,242 TrEMBL entries. The most
specific condition, the family IPR025532, is nested in the other two, so the conjunction selects the
same proteins as IPR025532 alone. All five Swiss-Prot members carry EC 5.1.3.15, one from a published
assay and four by similarity to it.
action: ACCEPT
action_rationale: The rule fires on a family signature named for the activity, and every reviewed member
has that activity in UniProt. The two broader conditions are redundant but harmless.
parsimony:
assessment: REDUNDANT
notes: 'IPR008183 and IPR011013 add nothing to IPR025532: of 9,248 UniProtKB entries with IPR025532,
one lacks IPR008183 and none lacks IPR011013 (UniProtKB queries, November 2026). The rule could be
reduced to IPR025532 without changing its output materially.'
literature_support:
assessment: MODERATE
notes: 'UniProt record Q03161 (YMY9_YEAST): catalytic activity RHEA:16249, EC 5.1.3.15, evidence ECO:0000269
PubMed:16857670. The other four Swiss-Prot members are annotated by similarity to Q03161.'
annotation_assessments:
- annotation_kind: CATALYTIC_ACTIVITY
value: RHEA:16249
label: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate (EC 5.1.3.15)
assessment: CORRECT
matched_protein_count: 9242
correct_examples:
- Q03161
- P39173
- Q8ZPV9
- P44160
- Q40784
notes: matched_protein_count is the TrEMBL count UniProt reports for the rule. Q03161 has experimental
evidence (PubMed:16857670); the other four have the activity by similarity (ECO:0000250).
confidence: 0.8
corrections:
- date: '2026-11-10'
withdrawn_claim: The rule effectively annotates only 5 proteins.
correction: Five is the number of Swiss-Prot entries with IPR025532. The rule annotates 9,242 TrEMBL
entries.
error_type: SAMPLE_OVERGENERALISED
evidence:
- 'rest.uniprot.org/arba/ARBA00001096 statistics: unreviewedProteinCount 9242'
- 'UniProtKB query (xref:interpro-IPR025532): 9,248 entries'
- date: '2026-11-10'
withdrawn_claim: The AND logic is overly restrictive and likely creates false negatives.
correction: Because IPR025532 is nested in the other two entries, the conjunction excludes one protein
out of 9,248. The same review had already stated this nesting.
error_type: OTHER
evidence:
- 'UniProtKB query (xref:interpro-IPR025532) AND NOT (xref:interpro-IPR008183): 1 entry'
- 'UniProtKB query (xref:interpro-IPR025532) AND NOT (xref:interpro-IPR011013): 0 entries'
- date: '2026-11-10'
withdrawn_claim: Alternatively, use OR logic across the three domains.
correction: OR logic would assign glucose-6-phosphate 1-epimerase activity to every protein of the galactose
mutarotase-like superfamily, which includes aldose 1-epimerases.
error_type: CONJUNCTION_IGNORED
evidence:
- 'Swiss-Prot counts recorded in rule.entries: IPR011013 397 entries, IPR008183 31, IPR025532 5'
- date: '2026-11-10'
withdrawn_claim: Literature support was assessed from ARBA00001096-deep-research-manual.md.
correction: That file is the reviewer's own notes. The support now cited is the UniProt record of Q03161.
error_type: UNSUPPORTED_SOURCE
evidence:
- Q03161 catalytic activity evidence ECO:0000269|PubMed:16857670