ARBA00004218

id: ARBA00004218
description: >-
  ARBA rule assigning the subcellular location "Cytoplasmic vesicle, secretory vesicle, acrosome"
  through 38 alternative condition sets, each a conjunction of family signatures with a taxon condition.
status: IN_PROGRESS
rule_type: ARBA
rule:
  rule_id: ARBA00004218
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR001873
      curie: InterPro:IPR001873
      label: Epithelial sodium channel
      negated: false
    - condition_type: INTERPRO
      value: IPR004724
      curie: InterPro:IPR004724
      label: Epithelial sodium channel, chordates
      negated: false
    - condition_type: PANTHER
      value: PTHR11690:SF124
      curie: PANTHER:PTHR11690:SF124
      label: AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    notes: >-
      Epithelial sodium channel alpha-subunit subfamily. Human SCNN1A (P37088) has the UniProt location
      "Cytoplasmic vesicle, secretory vesicle, acrosome" by similarity to rat P37089.
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR001100
      curie: InterPro:IPR001100
      label: Pyridine nucleotide-disulphide oxidoreductase, class I
      negated: false
    - condition_type: INTERPRO
      value: IPR006258
      curie: InterPro:IPR006258
      label: Dihydrolipoamide dehydrogenase
      negated: false
    - condition_type: TAXON
      value: Chordata
      label: Chordata
      negated: false
    notes: >-
      Dihydrolipoamide dehydrogenase family in Chordata. Human DLD (P09622) has the UniProt location
      "Cytoplasmic vesicle, secretory vesicle, acrosome" with ECO:0000269, PubMed:15888450, beside
      its main mitochondrial matrix location.
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR010857
      curie: InterPro:IPR010857
      label: Zona-pellucida-binding
      negated: false
    - condition_type: INTERPRO
      value: IPR048805
      curie: InterPro:IPR048805
      label: Zona-pellucida-binding protein 1/2, C-terminal domain
      negated: false
    - condition_type: INTERPRO
      value: IPR048806
      curie: InterPro:IPR048806
      label: Zona-pellucida-binding protein 1/2, N-terminal domain
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    notes: Zona-pellucida-binding protein family signatures.
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR000436
      curie: InterPro:IPR000436
      label: Sushi/SCR/CCP domain
      negated: false
    - condition_type: INTERPRO
      value: IPR017341
      curie: InterPro:IPR017341
      label: Membrane cofactor protein CD46
      negated: false
    - condition_type: TAXON
      value: Primates
      label: Primates
      negated: false
    notes: >-
      Membrane cofactor protein CD46 family in Primates. Human CD46 (P15529) has the UniProt location
      "acrosome inner membrane" with ECO:0000269 (PubMed:12112588, PubMed:14597734, PubMed:15307194).
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR001806
      curie: InterPro:IPR001806
      label: Small GTPase
      negated: false
    - condition_type: INTERPRO
      value: IPR037874
      curie: InterPro:IPR037874
      label: Cdc42
      negated: false
    - condition_type: TAXON
      value: Mammalia
      label: Mammalia
      negated: false
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR002347
      curie: InterPro:IPR002347
      label: Short-chain dehydrogenase/reductase SDR
      negated: false
    - condition_type: INTERPRO
      value: IPR020904
      curie: InterPro:IPR020904
      label: Short-chain dehydrogenase/reductase, conserved site
      negated: false
    - condition_type: PANTHER
      value: PTHR44252:SF2
      curie: PANTHER:PTHR44252:SF2
      label: L-XYLULOSE REDUCTASE
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR000008
      curie: InterPro:IPR000008
      label: C2 domain
      negated: false
    - condition_type: INTERPRO
      value: IPR002048
      curie: InterPro:IPR002048
      label: EF-hand domain
      negated: false
    - condition_type: PANTHER
      value: PTHR10336:SF29
      curie: PANTHER:PTHR10336:SF29
      label: 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR000435
      curie: InterPro:IPR000435
      label: Tektins
      negated: false
    - condition_type: INTERPRO
      value: IPR048256
      curie: InterPro:IPR048256
      label: Tektin-like
      negated: false
    - condition_type: PANTHER
      value: PTHR19960:SF24
      curie: PANTHER:PTHR19960:SF24
      label: TEKTIN-3
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR000974
      curie: InterPro:IPR000974
      label: Glycoside hydrolase, family 22, lysozyme
      negated: false
    - condition_type: PANTHER
      value: PTHR11407:SF25
      curie: PANTHER:PTHR11407:SF25
      label: SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 3
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      label: Euarchontoglires
      negated: false
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR003409
      curie: InterPro:IPR003409
      label: MORN repeat
      negated: false
    - condition_type: INTERPRO
      value: IPR052472
      curie: InterPro:IPR052472
      label: MORN repeat-containing protein 3
      negated: false
    - condition_type: PANTHER
      value: PTHR46511:SF1
      curie: PANTHER:PTHR46511:SF1
      label: MORN REPEAT-CONTAINING PROTEIN 3
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
  - number: 11
    conditions:
    - condition_type: INTERPRO
      value: IPR009865
      curie: InterPro:IPR009865
      label: Proacrosin binding sp32
      negated: false
    - condition_type: PANTHER
      value: PTHR21362:SF1
      curie: PANTHER:PTHR21362:SF1
      label: ACROSIN-BINDING PROTEIN
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
  - number: 12
    conditions:
    - condition_type: INTERPRO
      value: IPR013785
      curie: InterPro:IPR013785
      label: Aldolase-type TIM barrel
      negated: false
    - condition_type: INTERPRO
      value: IPR017853
      curie: InterPro:IPR017853
      label: Glycoside hydrolase superfamily
      negated: false
    - condition_type: INTERPRO
      value: IPR027260
      curie: InterPro:IPR027260
      label: Hyaluronidase-3
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR026118
      curie: InterPro:IPR026118
      label: Calcium-binding and spermatid-specific protein 1
      negated: false
    - condition_type: PANTHER
      value: PTHR22810:SF1
      curie: PANTHER:PTHR22810:SF1
      label: CALCIUM-BINDING AND SPERMATID-SPECIFIC PROTEIN 1
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      label: Euteleostomi
      negated: false
  - number: 14
    conditions:
    - condition_type: INTERPRO
      value: IPR026743
      curie: InterPro:IPR026743
      label: Sperm equatorial segment protein 1
      negated: false
    - condition_type: PANTHER
      value: PTHR31667:SF2
      curie: PANTHER:PTHR31667:SF2
      label: SPERM EQUATORIAL SEGMENT PROTEIN 1
      negated: false
    - condition_type: TAXON
      value: Eutheria
      label: Eutheria
      negated: false
  - number: 15
    conditions:
    - condition_type: FUNFAM
      value: 2.60.470.10:FF:000002
      curie: CATH.FunFam:2.60.470.10:FF:000002
      label: Amiloride-sensitive sodium channel subunit alpha
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 16
    conditions:
    - condition_type: FUNFAM
      value: 3.30.390.30:FF:000001
      curie: CATH.FunFam:3.30.390.30:FF:000001
      label: Dihydrolipoyl dehydrogenase
      negated: false
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000025
      curie: CATH.FunFam:3.50.50.60:FF:000025
      label: Dihydrolipoyl dehydrogenase
      negated: false
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000221
      curie: CATH.FunFam:3.50.50.60:FF:000221
      label: Dihydrolipoyl dehydrogenase, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 17
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000275
      curie: CATH.FunFam:3.40.50.300:FF:000275
      label: Putative ras-related protein Rab-2A
      negated: false
    - condition_type: TAXON
      value: Chordata
      label: Chordata
      negated: false
  - number: 18
    conditions:
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000014
      curie: CATH.FunFam:2.10.70.10:FF:000014
      label: Membrane cofactor protein
      negated: false
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000042
      curie: CATH.FunFam:2.10.70.10:FF:000042
      label: Membrane cofactor protein
      negated: false
    - condition_type: TAXON
      value: Primates
      label: Primates
      negated: false
  - number: 19
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000167
      curie: CATH.FunFam:3.40.50.300:FF:000167
      label: Cell division control protein 42 homolog
      negated: false
    - condition_type: TAXON
      value: Mammalia
      label: Mammalia
      negated: false
  - number: 20
    conditions:
    - condition_type: FUNFAM
      value: 1.10.238.10:FF:000005
      curie: CATH.FunFam:1.10.238.10:FF:000005
      label: Phosphoinositide phospholipase C
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.150:FF:000147
      curie: CATH.FunFam:2.60.40.150:FF:000147
      label: Phosphoinositide phospholipase C
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      label: Euarchontoglires
      negated: false
  - number: 21
    conditions:
    - condition_type: FUNFAM
      value: 1.25.40.420:FF:000006
      curie: CATH.FunFam:1.25.40.420:FF:000006
      negated: false
    - condition_type: FUNFAM
      value: 2.130.10.30:FF:000033
      curie: CATH.FunFam:2.130.10.30:FF:000033
      negated: false
    - condition_type: FUNFAM
      value: 2.130.10.30:FF:000038
      curie: CATH.FunFam:2.130.10.30:FF:000038
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 22
    conditions:
    - condition_type: FUNFAM
      value: 2.20.110.10:FF:000026
      curie: CATH.FunFam:2.20.110.10:FF:000026
      negated: false
    - condition_type: TAXON
      value: Metazoa
      label: Metazoa
      negated: false
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 1.10.238.10:FF:000065
      curie: CATH.FunFam:1.10.238.10:FF:000065
      label: calpain-3 isoform X1
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.380:FF:000001
      curie: CATH.FunFam:2.60.120.380:FF:000001
      label: Calpain-1 catalytic subunit
      negated: false
    - condition_type: FUNFAM
      value: 3.90.70.10:FF:000001
      curie: CATH.FunFam:3.90.70.10:FF:000001
      label: Calpain-1 catalytic subunit
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000095
      curie: CATH.FunFam:2.10.70.10:FF:000095
      label: Zona pellucida sperm-binding protein 3 receptor
      negated: false
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000115
      curie: CATH.FunFam:2.10.70.10:FF:000115
      label: Zona pellucida sperm-binding protein 3 receptor
      negated: false
    - condition_type: TAXON
      value: Glires
      label: Glires
      negated: false
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.150:FF:000176
      curie: CATH.FunFam:2.60.40.150:FF:000176
      label: Synaptotagmin 8
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.150:FF:000182
      curie: CATH.FunFam:2.60.40.150:FF:000182
      label: Synaptotagmin 8
      negated: false
    - condition_type: TAXON
      value: Craniata
      label: Craniata
      negated: false
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 1.25.40.10:FF:000281
      curie: CATH.FunFam:1.25.40.10:FF:000281
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      label: Vertebrata
      negated: false
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.70:FF:000141
      curie: CATH.FunFam:1.10.287.70:FF:000141
      label: Polycystin family receptor for egg jelly
      negated: false
    - condition_type: FUNFAM
      value: 2.60.60.20:FF:000016
      curie: CATH.FunFam:2.60.60.20:FF:000016
      label: Polycystin family receptor for egg jelly
      negated: false
    - condition_type: TAXON
      value: Eutheria
      label: Eutheria
      negated: false
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000767
      curie: CATH.FunFam:2.10.25.10:FF:000767
      label: Vasorin a
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000002
      curie: CATH.FunFam:2.60.120.260:FF:000002
      label: Coagulation factor VIII
      negated: false
    - condition_type: TAXON
      value: Rodentia
      label: Rodentia
      negated: false
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.920:FF:000029
      curie: CATH.FunFam:2.60.120.920:FF:000029
      label: E3 ubiquitin-protein ligase TRIM36
      negated: false
    - condition_type: FUNFAM
      value: 3.30.160.60:FF:000567
      curie: CATH.FunFam:3.30.160.60:FF:000567
      label: E3 ubiquitin-protein ligase TRIM36 isoform X1
      negated: false
    - condition_type: FUNFAM
      value: 4.10.830.40:FF:000001
      curie: CATH.FunFam:4.10.830.40:FF:000001
      label: E3 ubiquitin-protein ligase TRIM9 isoform X1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 2.70.150.10:FF:000024
      curie: CATH.FunFam:2.70.150.10:FF:000024
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1110.10:FF:000096
      curie: CATH.FunFam:3.40.1110.10:FF:000096
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1000:FF:000001
      curie: CATH.FunFam:3.40.50.1000:FF:000001
      label: Phospholipid-transporting ATPase IC
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000828
      curie: CATH.FunFam:3.40.50.300:FF:000828
      negated: false
    - condition_type: FUNFAM
      value: 3.80.10.10:FF:000191
      curie: CATH.FunFam:3.80.10.10:FF:000191
      negated: false
    - condition_type: FUNFAM
      value: 3.80.10.10:FF:000238
      curie: CATH.FunFam:3.80.10.10:FF:000238
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 1.10.472.80:FF:000037
      curie: CATH.FunFam:1.10.472.80:FF:000037
      label: TBC1 domain family member 21
      negated: false
    - condition_type: FUNFAM
      value: 1.10.8.270:FF:000029
      curie: CATH.FunFam:1.10.8.270:FF:000029
      label: TBC1 domain family member 21
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 1.10.510.10:FF:000443
      curie: CATH.FunFam:1.10.510.10:FF:000443
      label: Testis-specific serine/threonine-protein kinase 2
      negated: false
    - condition_type: TAXON
      value: Myomorpha
      label: Myomorpha
      negated: false
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 1.10.555.10:FF:000034
      curie: CATH.FunFam:1.10.555.10:FF:000034
      label: Rac GTPase-activating protein 1
      negated: false
    - condition_type: FUNFAM
      value: 3.30.60.20:FF:000033
      curie: CATH.FunFam:3.30.60.20:FF:000033
      label: Rac GTPase-activating protein 1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000139
      curie: CATH.FunFam:3.40.50.300:FF:000139
      label: ras-related protein Rab-6A isoform X1
      negated: false
    - condition_type: TAXON
      value: Muridae
      label: Muridae
      negated: false
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 3.90.79.10:FF:000043
      curie: CATH.FunFam:3.90.79.10:FF:000043
      negated: false
    - condition_type: TAXON
      value: Murinae
      label: Murinae
      negated: false
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 1.10.220.60:FF:000002
      curie: CATH.FunFam:1.10.220.60:FF:000002
      label: Golgin subfamily A member 1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 1.10.510.10:FF:000501
      curie: CATH.FunFam:1.10.510.10:FF:000501
      label: testis-specific serine/threonine-protein kinase 4 isoform X1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      label: Eukaryota
      negated: false
    - condition_type: TAXON
      value: Fungi
      label: Fungi
      negated: true
    - condition_type: TAXON
      value: Magnoliopsida
      label: Magnoliopsida
      negated: true
    - condition_type: TAXON
      value: Zygnematales
      label: Zygnematales
      negated: true
    - condition_type: TAXON
      value: Dictyostelium
      label: Dictyostelium
      negated: true
    - condition_type: TAXON
      value: Gnetales
      label: Gnetales
      negated: true
  go_annotations: []
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 11336
  created_date: '2020-05-12'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 38
review_summary: >-
  All 38 live condition sets are recorded. Three were checked against Swiss-Prot (sets 1, 2 and 4):
  each is a narrow conjunction defining one protein family, and the human member of each family carries
  a curated acrosome location in UniProt (CD46 and DLD experimentally, SCNN1A by similarity). Set
  3 is the zona-pellucida-binding protein family by its InterPro names. The other 34 sets were not
  checked against annotated proteins, so no verdict is given.
action: UNDECIDED
action_rationale: >-
  Three of 38 condition sets were checked and each reproduces a curated UniProt location. The remaining
  sets were not checked.
suggested_modifications:
- >-
  Check each remaining condition set against the Swiss-Prot subcellular location of its matched proteins.
- >-
  For set 2 (dihydrolipoamide dehydrogenase), decide whether a secondary location reported for sperm
  should be propagated to all chordate orthologues.
annotation_assessments:
- annotation_kind: OTHER
  value: 'SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome'
  assessment: UNDECIDED
  matched_protein_count: 11336
  correct_examples:
  - P15529
  - P09622
  notes: >-
    matched_protein_count is the unreviewedProteinCount from rest.uniprot.org/arba/ARBA00004218 on
    2026-11-09. P15529 (CD46): acrosome inner membrane, ECO:0000269, PubMed:12112588. P09622 (DLD):
    acrosome, ECO:0000269, PubMed:15888450. P37088 (SCNN1A): acrosome, ECO:0000250 from P37089.
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    Epithelial sodium channels, dihydrolipoamide dehydrogenase and CD46 have no literature supporting
    acrosomal localization.
  correction: >-
    All three human proteins carry a curated acrosome location in UniProt, two of them with experimental
    evidence.
  error_type: REFUTED_BY_CURATED_ANNOTATION
  evidence:
  - >-
    UniProtKB P15529 SUBCELLULAR LOCATION: acrosome inner membrane {ECO:0000269|PubMed:12112588}
  - 'UniProtKB P09622 SUBCELLULAR LOCATION: acrosome {ECO:0000269|PubMed:15888450}'
  - 'UniProtKB P37088 SUBCELLULAR LOCATION: acrosome {ECO:0000250|UniProtKB:P37089}'
- date: '2026-11-10'
  withdrawn_claim: >-
    The rule assigns acrosome location to unrelated families such as epithelial sodium channels and
    mitochondrial enzymes in general.
  correction: >-
    The condition sets are conjunctions that select one subfamily in a restricted taxon, not whole
    superfamilies.
  error_type: CONJUNCTION_IGNORED
  evidence:
  - >-
    Live set 1: IPR001873 AND IPR004724 AND PTHR11690:SF124 AND Eukaryota, excluding five plant, fungal
    and amoebozoan taxa
  - 'Live set 2: IPR001100 AND IPR006258 AND Chordata'
  - 'Live set 4: IPR000436 AND IPR017341 AND Primates'
- date: '2026-11-10'
  withdrawn_claim: The taxonomic restrictions (Primates, Chordata, Mammalia) are arbitrary.
  correction: >-
    No evidence was given that any restriction is wrong; restrictions to animal clades fit a sperm-specific
    location.
  error_type: TAXON_MISREAD
  evidence:
  - 'Live rule: every one of the 38 sets carries a taxon condition'
- date: '2026-11-10'
  withdrawn_claim: The rule should be removed (stated with confidence 0.1).
  correction: >-
    A verdict held at 0.1 is not a verdict; the action is now undecided pending a set-by-set check.
  error_type: UNEXAMINED_RULE
  evidence:
  - 'Previous file recorded condition_sets: []'
- date: '2026-11-10'
  withdrawn_claim: Literature contradicts the rule.
  correction: The only source was the review's own notes file; the assessment is removed.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - Previous literature_support cited ARBA00004218-deep-research-manual.md only