ARBA00022438

id: ARBA00022438
description: Assigns the UniProt keyword Aminopeptidase (KW-0031) through 90 alternative condition sets built from
  InterPro entries, PANTHER subfamilies and CATH FunFams, 38 of them with a taxon condition.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00022438
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR000819
      curie: InterPro:IPR000819
      label: Peptidase M17, leucyl aminopeptidase, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR011356
      curie: InterPro:IPR011356
      label: Peptidase M17, leucine aminopeptidase/peptidase B
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR064115
      curie: InterPro:IPR064115
      label: Cytosol aminopeptidase-like, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 507 (first 500 inspected). 500 carry keyword KW-0031
      Aminopeptidase. UniProtKB entries matching: 26157.'
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR023042
      curie: InterPro:IPR023042
      label: Peptidase M17, leucine aminopeptidase
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 435. 435 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 16674.'
  - number: 3
    conditions:
    - condition_type: PANTHER
      value: PTHR11963:SF23
      curie: PANTHER:PTHR11963:SF23
      label: CYTOSOL AMINOPEPTIDASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 430. 430 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 19982.'
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR001261
      curie: InterPro:IPR001261
      label: ArgE/DapE/ACY1/CPG2/YscS, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR010161
      curie: InterPro:IPR010161
      label: Peptidase M20B, tripeptide aminopeptidase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 121. 121 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2710.'
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR002468
      curie: InterPro:IPR002468
      label: Peptidase M24A, methionine aminopeptidase, subfamily 2
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036005
      curie: InterPro:IPR036005
      label: Creatinase/aminopeptidase-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 110. 110 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 6325.'
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR052433
      curie: InterPro:IPR052433
      label: Xaa-Pro dipeptidase-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Pezizomycotina
      curie: NCBITaxon:147538
      label: Pezizomycotina
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 78. 78 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2628.'
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR002467
      curie: InterPro:IPR002467
      label: Peptidase M24A, methionine aminopeptidase, subfamily 1
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR43330
      curie: PANTHER:PTHR43330
      label: METHIONINE AMINOPEPTIDASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 65. 65 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 38711.'
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR001375
      curie: InterPro:IPR001375
      label: Peptidase S9, prolyl oligopeptidase, catalytic domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR002469
      curie: InterPro:IPR002469
      label: Dipeptidylpeptidase IV, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 64. 64 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2517.'
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR010384
      curie: InterPro:IPR010384
      label: MtfA family
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR024079
      curie: InterPro:IPR024079
      label: Metallopeptidase, catalytic domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR057256
      curie: InterPro:IPR057256
      label: MtfA, enterobacterales
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 62. 62 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 429.'
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR000383
      curie: InterPro:IPR000383
      label: Xaa-Pro dipeptidyl-peptidase-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR008252
      curie: InterPro:IPR008252
      label: Peptidase S15, X-Pro dipeptidyl-peptidase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR008979
      curie: InterPro:IPR008979
      label: Galactose-binding-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 59. 59 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2103.'
  - number: 11
    conditions:
    - condition_type: INTERPRO
      value: IPR007484
      curie: InterPro:IPR007484
      label: Peptidase M28
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR045175
      curie: InterPro:IPR045175
      label: Peptidase M28 family
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR12147:SF56
      curie: PANTHER:PTHR12147:SF56
      label: AMINOPEPTIDASE YDR415C-RELATED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 58. 58 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 7731.'
  - number: 12
    conditions:
    - condition_type: PANTHER
      value: PTHR11731:SF200
      curie: PANTHER:PTHR11731:SF200
      label: DIPEPTIDYL PEPTIDASE 10, ISOFORM B
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 50. 50 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 3298.'
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR001131
      curie: InterPro:IPR001131
      label: Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: TAXON
      value: Eurotiomycetes
      curie: NCBITaxon:147545
      label: Eurotiomycetes
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 49. 49 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 421.'
  - number: 14
    conditions:
    - condition_type: INTERPRO
      value: IPR001948
      curie: InterPro:IPR001948
      label: Peptidase M18
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023358
      curie: InterPro:IPR023358
      label: Peptidase M18, domain 2
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 48. 48 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 11578.'
  - number: 15
    conditions:
    - condition_type: INTERPRO
      value: IPR001930
      curie: InterPro:IPR001930
      label: Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR014782
      curie: InterPro:IPR014782
      label: Peptidase M1, membrane alanine aminopeptidase
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR11533:SF174
      curie: PANTHER:PTHR11533:SF174
      label: PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 28. 28 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 18412.'
  - number: 16
    conditions:
    - condition_type: INTERPRO
      value: IPR008007
      curie: InterPro:IPR008007
      label: Peptidase M42
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023367
      curie: InterPro:IPR023367
      label: Peptidase M42, domain 2
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 12319.'
  - number: 17
    conditions:
    - condition_type: INTERPRO
      value: IPR001466
      curie: InterPro:IPR001466
      label: Beta-lactamase-related
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR012338
      curie: InterPro:IPR012338
      label: Beta-lactamase/transpeptidase-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR012856
      curie: InterPro:IPR012856
      label: D-aminopeptidase, domain B
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 547.'
  - number: 18
    conditions:
    - condition_type: INTERPRO
      value: IPR000587
      curie: InterPro:IPR000587
      label: Creatinase, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR032416
      curie: InterPro:IPR032416
      label: Peptidase M24, C-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Onygenales
      curie: NCBITaxon:33183
      label: Onygenales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 30.'
  - number: 19
    conditions:
    - condition_type: INTERPRO
      value: IPR000073
      curie: InterPro:IPR000073
      label: Alpha/beta hydrolase fold-1
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR002410
      curie: InterPro:IPR002410
      label: Peptidase S33
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR005944
      curie: InterPro:IPR005944
      label: Proline iminopeptidase
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 10091.'
  - number: 20
    conditions:
    - condition_type: INTERPRO
      value: IPR003137
      curie: InterPro:IPR003137
      label: PA domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR041756
      curie: InterPro:IPR041756
      label: Peptidase M28, SGAP-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR046450
      curie: InterPro:IPR046450
      label: PA domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2694.'
  - number: 21
    conditions:
    - condition_type: INTERPRO
      value: IPR024571
      curie: InterPro:IPR024571
      label: ERAP1-like C-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR027268
      curie: InterPro:IPR027268
      label: Peptidase M4/M1, CTD superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 299.'
  - number: 22
    conditions:
    - condition_type: INTERPRO
      value: IPR033740
      curie: InterPro:IPR033740
      label: Aminopeptidase P
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050422
      curie: InterPro:IPR050422
      label: Xaa-Pro aminopeptidase P
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Eurotiales
      curie: NCBITaxon:5042
      label: Eurotiales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 163.'
  - number: 23
    conditions:
    - condition_type: INTERPRO
      value: IPR009003
      curie: InterPro:IPR009003
      label: Peptidase S1, PA clan
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR019500
      curie: InterPro:IPR019500
      label: Peptidase S46
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR38469:SF1
      curie: PANTHER:PTHR38469:SF1
      label: PERIPLASMIC PEPTIDASE SUBFAMILY S1B
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 4062.'
  - number: 24
    conditions:
    - condition_type: PANTHER
      value: PTHR43330:SF27
      curie: PANTHER:PTHR43330:SF27
      label: METHIONINE AMINOPEPTIDASE
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 4057.'
  - number: 25
    conditions:
    - condition_type: INTERPRO
      value: IPR005945
      curie: InterPro:IPR005945
      label: Proline-specific peptidase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050266
      curie: InterPro:IPR050266
      label: AB hydrolase RutD-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Lactobacillaceae
      curie: NCBITaxon:33958
      label: Lactobacillaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 585.'
  - number: 26
    conditions:
    - condition_type: INTERPRO
      value: IPR000209
      curie: InterPro:IPR000209
      label: Peptidase S8/S53 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR015500
      curie: InterPro:IPR015500
      label: Peptidase S8, subtilisin-related
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR022229
      curie: InterPro:IPR022229
      label: Tripeptidyl peptidase II, second Ig-like domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2849.'
  - number: 27
    conditions:
    - condition_type: INTERPRO
      value: IPR034016
      curie: InterPro:IPR034016
      label: Aminopeptidase N-type
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR042097
      curie: InterPro:IPR042097
      label: Aminopeptidase N-like , N-terminal domain superfamliy
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR11533:SF172
      curie: PANTHER:PTHR11533:SF172
      label: AMINOPEPTIDASE N
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1412.'
  - number: 28
    conditions:
    - condition_type: INTERPRO
      value: IPR045357
      curie: InterPro:IPR045357
      label: Aminopeptidase N-like , N-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050344
      curie: InterPro:IPR050344
      label: Peptidase M1 family aminopeptidases
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Laurasiatheria
      curie: NCBITaxon:314145
      label: Laurasiatheria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 979.'
  - number: 29
    conditions:
    - condition_type: INTERPRO
      value: IPR039461
      curie: InterPro:IPR039461
      label: Peptidase family M49
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR061912
      curie: InterPro:IPR061912
      label: Dipeptidyl peptidase 3
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR23422:SF11
      curie: PANTHER:PTHR23422:SF11
      label: DIPEPTIDYL PEPTIDASE 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 4410.'
  - number: 30
    conditions:
    - condition_type: PANTHER
      value: PTHR11533:SF276
      curie: PANTHER:PTHR11533:SF276
      label: GLUTAMYL AMINOPEPTIDASE
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2407.'
  - number: 31
    conditions:
    - condition_type: INTERPRO
      value: IPR012779
      curie: InterPro:IPR012779
      label: Peptidase M1, alanyl aminopeptidase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR024601
      curie: InterPro:IPR024601
      label: Peptidase M1, alanyl aminopeptidase, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR035414
      curie: InterPro:IPR035414
      label: Peptidase M1, alanyl aminopeptidase, Ig-like fold
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 7297.'
  - number: 32
    conditions:
    - condition_type: INTERPRO
      value: IPR040043
      curie: InterPro:IPR040043
      label: Actin maturation protease
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR28631:SF1
      curie: PANTHER:PTHR28631:SF1
      label: ACTIN MATURATION PROTEASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1149.'
  - number: 33
    conditions:
    - condition_type: PANTHER
      value: PTHR11731:SF128
      curie: PANTHER:PTHR11731:SF128
      label: DIPEPTIDYL PEPTIDASE 4
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 817.'
  - number: 34
    conditions:
    - condition_type: INTERPRO
      value: IPR000787
      curie: InterPro:IPR000787
      label: Peptidase M29
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR035097
      curie: InterPro:IPR035097
      label: Peptidase M29, N-terminal
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR052170
      curie: InterPro:IPR052170
      label: Metal-dependent Exopeptidase M29
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 7211.'
  - number: 35
    conditions:
    - condition_type: INTERPRO
      value: IPR045785
      curie: InterPro:IPR045785
      label: Dipeptidyl peptidase 8 /9 ,N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2656.'
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000004
      curie: CATH.FunFam:3.40.630.10:FF:000004
      label: Probable cytosol aminopeptidase
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 185. 185 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 3106.'
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.360:FF:000002
      curie: CATH.FunFam:3.30.70.360:FF:000002
      label: Peptidase T
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 177. 177 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2494.'
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000037
      curie: CATH.FunFam:3.40.630.10:FF:000037
      label: Peptidase B
      negated: false
    - condition_type: TAXON
      value: Pseudomonadota
      curie: NCBITaxon:1224
      label: Pseudomonadota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 63. 63 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 766.'
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 1.10.472.150:FF:000001
      curie: CATH.FunFam:1.10.472.150:FF:000001
      label: Protein MtfA
      negated: false
    - condition_type: FUNFAM
      value: 3.40.390.10:FF:000012
      curie: CATH.FunFam:3.40.390.10:FF:000012
      label: Protein MtfA
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 62. 62 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 431.'
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000003
      curie: CATH.FunFam:3.40.50.1820:FF:000003
      label: Dipeptidyl peptidase 4
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 62. 62 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2112.'
  - number: 41
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000042
      curie: CATH.FunFam:3.40.630.10:FF:000042
      label: Peptide hydrolase
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 56. 56 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1753.'
  - number: 42
    conditions:
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000010
      curie: CATH.FunFam:3.40.350.10:FF:000010
      label: Probable Xaa-Pro aminopeptidase P
      negated: false
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000007
      curie: CATH.FunFam:3.90.230.10:FF:000007
      label: Xaa-Pro aminopeptidase P
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 44. 44 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1524.'
  - number: 43
    conditions:
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000003
      curie: CATH.FunFam:3.40.350.10:FF:000003
      label: Xaa-pro aminopeptidase P
      negated: false
    - condition_type: TAXON
      value: Pezizomycotina
      curie: NCBITaxon:147538
      label: Pezizomycotina
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 38. 38 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 828.'
  - number: 44
    conditions:
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000002
      curie: CATH.FunFam:3.90.230.10:FF:000002
      label: Xaa-Pro aminopeptidase 3
      negated: false
    - condition_type: TAXON
      value: Eurotiomycetes
      curie: NCBITaxon:147545
      label: Eurotiomycetes
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 192.'
  - number: 45
    conditions:
    - condition_type: FUNFAM
      value: 2.30.250.10:FF:000003
      curie: CATH.FunFam:2.30.250.10:FF:000003
      label: Probable M18 family aminopeptidase 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 19. 19 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 948.'
  - number: 46
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000370
      curie: CATH.FunFam:1.10.10.10:FF:000370
      label: Methionine aminopeptidase 2
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 135.'
  - number: 47
    conditions:
    - condition_type: FUNFAM
      value: 2.140.10.30:FF:000003
      curie: CATH.FunFam:2.140.10.30:FF:000003
      label: Probable dipeptidyl peptidase 4
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 96.'
  - number: 48
    conditions:
    - condition_type: FUNFAM
      value: 1.10.390.10:FF:000006
      curie: CATH.FunFam:1.10.390.10:FF:000006
      label: Puromycin-sensitive aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 3628.'
  - number: 49
    conditions:
    - condition_type: FUNFAM
      value: 1.10.390.10:FF:000001
      curie: CATH.FunFam:1.10.390.10:FF:000001
      label: Aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 6336.'
  - number: 50
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000033
      curie: CATH.FunFam:3.40.630.10:FF:000033
      label: M17 leucyl aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 801.'
  - number: 51
    conditions:
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000010
      curie: CATH.FunFam:3.90.230.10:FF:000010
      label: Methionine aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2849.'
  - number: 52
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.1730:FF:000012
      curie: CATH.FunFam:2.60.40.1730:FF:000012
      label: Aminopeptidase N
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1910:FF:000005
      curie: CATH.FunFam:2.60.40.1910:FF:000005
      label: Aminopeptidase
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 396.'
  - number: 53
    conditions:
    - condition_type: FUNFAM
      value: 1.10.390.10:FF:000016
      curie: CATH.FunFam:1.10.390.10:FF:000016
      label: Glutamyl aminopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 1.25.50.20:FF:000012
      curie: CATH.FunFam:1.25.50.20:FF:000012
      label: Aminopeptidase N
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1815.'
  - number: 54
    conditions:
    - condition_type: FUNFAM
      value: 1.25.50.20:FF:000003
      curie: CATH.FunFam:1.25.50.20:FF:000003
      label: Leucyl-cystinyl aminopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1910:FF:000001
      curie: CATH.FunFam:2.60.40.1910:FF:000001
      label: Leucyl-cystinyl aminopeptidase
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2591.'
  - number: 55
    conditions:
    - condition_type: FUNFAM
      value: 1.10.390.10:FF:000013
      curie: CATH.FunFam:1.10.390.10:FF:000013
      label: Aminopeptidase N
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2731.'
  - number: 56
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000054
      curie: CATH.FunFam:3.40.630.10:FF:000054
      label: Peptide hydrolase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1202.'
  - number: 57
    conditions:
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000001
      curie: CATH.FunFam:3.90.230.10:FF:000001
      label: Methionine aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 932.'
  - number: 58
    conditions:
    - condition_type: FUNFAM
      value: 2.30.250.10:FF:000004
      curie: CATH.FunFam:2.30.250.10:FF:000004
      label: Probable M18 family aminopeptidase 2
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 877.'
  - number: 59
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000087
      curie: CATH.FunFam:3.40.630.10:FF:000087
      label: Probable cytosol aminopeptidase
      negated: false
    - condition_type: TAXON
      value: Actinomycetota
      curie: NCBITaxon:201174
      label: Actinomycetota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 19.'
  - number: 60
    conditions:
    - condition_type: FUNFAM
      value: 1.25.50.20:FF:000001
      curie: CATH.FunFam:1.25.50.20:FF:000001
      label: Aminopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1730:FF:000006
      curie: CATH.FunFam:2.60.40.1730:FF:000006
      label: Aminopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1910:FF:000003
      curie: CATH.FunFam:2.60.40.1910:FF:000003
      label: Aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 822.'
  - number: 61
    conditions:
    - condition_type: FUNFAM
      value: 2.30.250.10:FF:000006
      curie: CATH.FunFam:2.30.250.10:FF:000006
      label: Probable M18 family aminopeptidase 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 623.'
  - number: 62
    conditions:
    - condition_type: FUNFAM
      value: 3.30.540.30:FF:000001
      curie: CATH.FunFam:3.30.540.30:FF:000001
      label: Dipeptidyl peptidase 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2879.'
  - number: 63
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000031
      curie: CATH.FunFam:3.40.630.10:FF:000031
      label: cytosol aminopeptidase
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 930.'
  - number: 64
    conditions:
    - condition_type: FUNFAM
      value: 2.30.250.10:FF:000001
      curie: CATH.FunFam:2.30.250.10:FF:000001
      label: Aspartyl aminopeptidase 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 3948.'
  - number: 65
    conditions:
    - condition_type: FUNFAM
      value: 3.30.2010.30:FF:000002
      curie: CATH.FunFam:3.30.2010.30:FF:000002
      label: Putative aminopeptidase N
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 7182.'
  - number: 66
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000003
      curie: CATH.FunFam:3.40.50.200:FF:000003
      label: Tripeptidyl peptidase 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1949.'
  - number: 67
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000009
      curie: CATH.FunFam:3.40.50.200:FF:000009
      label: tripeptidyl-peptidase 2 isoform X1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1592.'
  - number: 68
    conditions:
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000003
      curie: CATH.FunFam:3.90.230.10:FF:000003
      label: Methionine aminopeptidase 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1775.'
  - number: 69
    conditions:
    - condition_type: FUNFAM
      value: 1.10.390.10:FF:000003
      curie: CATH.FunFam:1.10.390.10:FF:000003
      label: Leukotriene A(4) hydrolase
      negated: false
    - condition_type: FUNFAM
      value: 1.25.40.320:FF:000001
      curie: CATH.FunFam:1.25.40.320:FF:000001
      label: Leukotriene A(4) hydrolase
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 390.'
  - number: 70
    conditions:
    - condition_type: FUNFAM
      value: 2.140.10.30:FF:000002
      curie: CATH.FunFam:2.140.10.30:FF:000002
      label: Dipeptidyl peptidase 8-like isoform
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000016
      curie: CATH.FunFam:3.40.50.1820:FF:000016
      label: Dipeptidyl peptidase 8-like isoform
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 2107.'
  - number: 71
    conditions:
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000011
      curie: CATH.FunFam:3.90.230.10:FF:000011
      label: Methionine aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1244.'
  - number: 72
    conditions:
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000001
      curie: CATH.FunFam:3.40.350.10:FF:000001
      label: Putative xaa-Pro aminopeptidase 1
      negated: false
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000004
      curie: CATH.FunFam:3.40.350.10:FF:000004
      label: xaa-Pro aminopeptidase 1 isoform X1
      negated: false
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000004
      curie: CATH.FunFam:3.90.230.10:FF:000004
      label: xaa-Pro aminopeptidase 1 isoform X1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1260.'
  - number: 73
    conditions:
    - condition_type: FUNFAM
      value: 2.30.250.10:FF:000002
      curie: CATH.FunFam:2.30.250.10:FF:000002
      label: Aspartyl aminopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000152
      curie: CATH.FunFam:3.40.630.10:FF:000152
      label: aspartyl aminopeptidase isoform X2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 387.'
  - number: 74
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000128
      curie: CATH.FunFam:2.40.10.10:FF:000128
      label: S46 family peptidase
      negated: false
    - condition_type: TAXON
      value: Bacteroidota
      curie: NCBITaxon:976
      label: Bacteroidota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 70.'
  - number: 75
    conditions:
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000008
      curie: CATH.FunFam:3.40.350.10:FF:000008
      label: xaa-Pro aminopeptidase 2
      negated: false
    - condition_type: FUNFAM
      value: 3.90.230.10:FF:000009
      curie: CATH.FunFam:3.90.230.10:FF:000009
      label: xaa-Pro aminopeptidase 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 359.'
  - number: 76
    conditions:
    - condition_type: FUNFAM
      value: 3.60.70.12:FF:000003
      curie: CATH.FunFam:3.60.70.12:FF:000003
      label: Putative cysteine transferase
      negated: false
    - condition_type: TAXON
      value: Actinomycetes
      curie: NCBITaxon:1760
      label: Actinomycetes
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 907.'
  - number: 77
    conditions:
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000035
      curie: CATH.FunFam:3.40.630.10:FF:000035
      label: Probable aminopeptidase NPEPL1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 953.'
  - number: 78
    conditions:
    - condition_type: FUNFAM
      value: 1.10.390.10:FF:000014
      curie: CATH.FunFam:1.10.390.10:FF:000014
      label: aminopeptidase O isoform X1
      negated: false
    - condition_type: FUNFAM
      value: 1.25.40.320:FF:000003
      curie: CATH.FunFam:1.25.40.320:FF:000003
      label: Aminopeptidase O isoform 1
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1730:FF:000008
      curie: CATH.FunFam:2.60.40.1730:FF:000008
      label: aminopeptidase O isoform X1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 287.'
  - number: 79
    conditions:
    - condition_type: FUNFAM
      value: 1.20.930.40:FF:000001
      curie: CATH.FunFam:1.20.930.40:FF:000001
      label: N-acetylated-alpha-linked acidic dipeptidase 2
      negated: false
    - condition_type: FUNFAM
      value: 3.40.630.10:FF:000101
      curie: CATH.FunFam:3.40.630.10:FF:000101
      label: N-acetylated alpha-linked acidic dipeptidase like 1
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 77.'
  - number: 80
    conditions:
    - condition_type: FUNFAM
      value: 1.25.50.20:FF:000005
      curie: CATH.FunFam:1.25.50.20:FF:000005
      label: Aminopeptidase N-like protein
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1730:FF:000007
      curie: CATH.FunFam:2.60.40.1730:FF:000007
      label: thyrotropin-releasing hormone-degrading ectoenzyme
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1910:FF:000006
      curie: CATH.FunFam:2.60.40.1910:FF:000006
      label: Aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 476.'
  - number: 81
    conditions:
    - condition_type: FUNFAM
      value: 3.90.70.10:FF:000091
      curie: CATH.FunFam:3.90.70.10:FF:000091
      label: Aminopeptidase C
      negated: false
    - condition_type: TAXON
      value: Bacillota
      curie: NCBITaxon:1239
      label: Bacillota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 241.'
  - number: 82
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.1910:FF:000002
      curie: CATH.FunFam:2.60.40.1910:FF:000002
      label: Aminopeptidase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 1707.'
  - number: 83
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000484
      curie: CATH.FunFam:3.40.50.1820:FF:000484
      label: Dipeptidyl peptidase 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 928.'
  - number: 84
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000013
      curie: CATH.FunFam:3.40.50.200:FF:000013
      label: Tripeptidyl-peptidase 2 homolog
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 727.'
  - number: 85
    conditions:
    - condition_type: FUNFAM
      value: 2.120.10.30:FF:000079
      curie: CATH.FunFam:2.120.10.30:FF:000079
      label: S9 family peptidase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000028
      curie: CATH.FunFam:3.40.50.1820:FF:000028
      label: S9 family peptidase
      negated: false
    - condition_type: TAXON
      value: Bacteroidia
      curie: NCBITaxon:200643
      label: Bacteroidia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 149.'
  - number: 86
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.650:FF:000019
      curie: CATH.FunFam:2.60.120.650:FF:000019
      label: Bifunctional peptidase and arginyl-hydroxylase JMJD5
      negated: false
    - condition_type: TAXON
      value: Rodentia
      curie: NCBITaxon:9989
      label: Rodentia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 37.'
  - number: 87
    conditions:
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000013
      curie: CATH.FunFam:3.40.350.10:FF:000013
      label: probable Xaa-Pro aminopeptidase 3
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 56.'
  - number: 88
    conditions:
    - condition_type: FUNFAM
      value: 3.60.60.20:FF:000001
      curie: CATH.FunFam:3.60.60.20:FF:000001
      label: Phospholipase B-like
      negated: false
    - condition_type: TAXON
      value: Muroidea
      curie: NCBITaxon:337687
      label: Muroidea
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 20.'
  - number: 89
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000102
      curie: CATH.FunFam:2.40.10.10:FF:000102
      label: Dipeptidyl-peptidase 7
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 636.'
  - number: 90
    conditions:
    - condition_type: FUNFAM
      value: 3.40.350.10:FF:000015
      curie: CATH.FunFam:3.40.350.10:FF:000015
      label: Xaa-Pro aminopeptidase app-1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry keyword KW-0031 Aminopeptidase. UniProtKB
      entries matching: 140.'
  go_annotations: []
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 199349
  created_date: '2020-05-12'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 90
review_summary: All 90 live condition sets were checked against Swiss-Prot. Every set has reviewed matches (2 to
  507 per set) and every reviewed match inspected carries the keyword Aminopeptidase; for set 1, the first 500 of
  507 matches were inspected. Checked against Swiss-Prot by UniProtKB query on 2026-11-09; TrEMBL matches were counted
  but not inspected.
action: ACCEPT
action_rationale: 'Every live condition set is supported by curated Swiss-Prot annotation: no reviewed match of
  any of the 90 sets lacks the keyword.'
annotation_assessments:
- annotation_kind: KEYWORD
  value: KW-0031
  label: Aminopeptidase
  assessment: CORRECT
  correct_examples:
  - P28838
  - P00727
  - P68767
  - P50579
  - P38062
  - P37095
  notes: '90 of 90 sets: all inspected Swiss-Prot matches carry KW-0031 (counts per set in rule.condition_sets notes).
    Rule statistics: 199349 unreviewed proteins.'
confidence: 0.8
corrections:
- date: '2026-11-10'
  withdrawn_claim: The rule has a high false positive risk and a high likelihood of annotating non-aminopeptidases.
  correction: No false positive was shown, and the condition sets had not been read (the earlier file listed none).
    Checked set by set, every reviewed match carries the keyword.
  error_type: UNEXAMINED_RULE
  evidence:
  - 90 live condition sets queried against Swiss-Prot on 2026-11-09; 0 reviewed matches without KW-0031
- date: '2026-11-10'
  withdrawn_claim: 86 condition sets are too many, and combining mechanistically distinct peptidase families is
    a design flaw that requires the rule to be decomposed.
  correction: The keyword Aminopeptidase applies to any aminopeptidase whatever its catalytic mechanism, so covering
    several families is what the annotation requires. Set count is not evidence of error.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'Live rule: 90 condition sets; consequent keyword KW-0031 Aminopeptidase'
- date: '2026-11-10'
  withdrawn_claim: The rule covers the M2 (angiotensin-converting enzyme) family.
  correction: No condition of the live rule is the peptidase M2 signature.
  error_type: UNEXAMINED_RULE
  evidence:
  - Live rule conditions (2026-11-09) do not include InterPro IPR001548
- date: '2026-11-10'
  withdrawn_claim: The absence of GO terms is a critical flaw of the rule.
  correction: This is a keyword rule. Not emitting GO terms is not an error in the keyword it assigns.
  error_type: OTHER
  evidence:
  - 'Live rule annotation: keyword KW-0031'
- date: '2026-11-10'
  withdrawn_claim: Mixing taxon-restricted and unrestricted condition sets makes the taxonomic scope too broad and
    inconsistent.
  correction: Sets built on different signatures need not share a taxon scope, and no wrongly annotated taxon was
    shown.
  error_type: TAXON_MISREAD
  evidence:
  - 'Live rule: 38 of 90 sets carry a taxon condition; all reviewed matches of all sets carry the keyword'