ARBA00022487

View original ARBA rule on UniProt

Type: ARBA
Status: COMPLETE
Action: ACCEPT
Confidence: 0.60

Description

Assigns the UniProt keyword KW-0719 (Serine esterase) through 65 alternative condition sets built from InterPro, PANTHER and CATH FunFam signatures.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
65
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00022487 and re-render to add it.

Review Summary

All 65 live condition sets were screened with two UniProtKB queries each (2026-11-10): the Swiss-Prot entries that match the whole conjunction, and how many of them carry KW-0719 Serine esterase. Every set matches at least one Swiss-Prot entry. Summed over sets there are 1,028 set-level matches (an entry that matches several sets is counted once per set) and 1,028 of them carry the keyword. No set has a Swiss-Prot match without the keyword. All 65 sets are recorded in the rule block with official signature names. 46 of the 65 sets have a taxon condition. ARBA rules are mined from Swiss-Prot annotation, so this screen shows that no set conflicts with curated keywords; it does not measure precision on the 83,725 unreviewed entries the rule annotates.

Action Rationale

The keyword Serine esterase is defined by UniProt as: Enzyme which catalyzes the hydrolysis of esters and is characterized by a catalytically active serine residue in its active site. It is a class label, so its members are expected to be diverse. In every one of the 65 condition sets all Swiss-Prot matches carry the keyword. The rule emits a keyword, not a GO term; UniProt maps KW-0719 to GO:0052689 carboxylic ester hydrolase activity. Confidence is moderate because the evidence is agreement with Swiss-Prot, the source ARBA rules are mined from, and precision on unreviewed entries was not measured.

Annotation Assessments

CORRECT KEYWORD KW-0719 - Serine esterase
Matched proteins: ; incorrect:
Correct examples: P13001, Q8GHL1, P04335, Q8DF91, P9WP43, A0A024SC78, P11373, P52956

UniProt keyword KW-0719 definition: Enzyme which catalyzes the hydrolysis of esters and is characterized by a catalytically active serine residue in its active site. UniProt keyword-to-GO mapping: GO:0052689 carboxylic ester hydrolase activity. Set-level Swiss-Prot matches 1,028; with the keyword 1,028. The examples are Swiss-Prot entries that match a recorded condition set and carry the keyword.

Rule Definition

Condition Sets

Condition Set 1

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 106; of these 106 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P13001 (bioH), Q8GHL1 (bioH).

Condition Set 2

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 69; of these 69 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P04335 (frsA), Q8DF91 (frsA).

Condition Set 3

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 54; of these 54 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P9WP43 (cut7), A0A024SC78 (no gene name).

Condition Set 4

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 47; of these 47 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: A0A024SC78 (no gene name), P11373 (CUTA).

Condition Set 5

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 41; of these 41 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P9WP43 (cut7), P52956 (cutL1).

Condition Set 6

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 39; of these 39 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P22303 (ACHE), P06276 (BCHE).

Condition Set 7

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 38; of these 38 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P10768 (ESD), P33018 (yeiG).

Condition Set 8

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 37; of these 37 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P23872 (aes), B5EXN3 (aes).

Condition Set 9

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 32; of these 32 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P07140 (Ace), P38433 (ace-1).

Condition Set 10

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 22; of these 22 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9Y570 (PPME1), Q4FZT2 (Ppme1).

Condition Set 11

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 22; of these 22 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: A0A0K8P8E7 (no gene name), P78581 (no gene name).

Condition Set 12

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 18; of these 18 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P08171 (Est-6), P25726 (Est-5B).

Condition Set 13

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 17; of these 17 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: G2QND5 (Fae1a), Q8NJP6 (axeA).

Condition Set 14

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 16; of these 16 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P08910 (ABHD2), Q8WU67 (ABHD3).

Condition Set 15

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 16; of these 16 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: A6WFI5 (cut), P9WP43 (cut7).

Condition Set 16

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 15; of these 15 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q12354 (no gene name), O42881 (no gene name).

Condition Set 17

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 13; of these 13 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: A0A0A7EQR3 (no gene name), G0RV93 (cip2).

Condition Set 18

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 8; of these 8 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: F7IX06 (est2), G8GER6 (cut_1).

Condition Set 19

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: O42807 (faeA), Q9P979 (faeA).

Condition Set 20

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q8VHQ9 (Acot11), Q91V12 (Acot7).

Condition Set 21

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 6; of these 6 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P82597 (no gene name), A0A0H2XJL0 (fphH).

Condition Set 22

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q8WYK0 (ACOT12), Q8WXI4 (ACOT11).

Condition Set 23

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q14032 (BAAT), Q86TX2 (ACOT1).

Condition Set 24

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9SE93 (PNAE), P0DO80 (NS1).

Condition Set 25

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q49412 (no gene name), P75333 (no gene name).

Condition Set 26

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 56; of these 56 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P04335 (frsA), A8AKP9 (frsA).

Condition Set 27

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 47; of these 47 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P13001 (bioH), Q8GHL1 (bioH).

Condition Set 28

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 38; of these 38 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P52956 (cutL1), Q5AVY9 (cut2).

Condition Set 29

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 37; of these 37 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P23872 (aes), B5EXN3 (aes).

Condition Set 30

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 36; of these 36 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P10768 (ESD), P33018 (yeiG).

Condition Set 31

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 26; of these 26 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P22303 (ACHE), P06276 (BCHE).

Condition Set 32

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 13; of these 13 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P08171 (Est-6), P25726 (Est-5B).

Condition Set 33

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: O00748 (CES2), P23141 (CES1).

Condition Set 34

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9HE18 (FAEB), Q5B037 (axeA).

Condition Set 35

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 6; of these 6 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q4I8Q4 (no gene name), P0CL94 (no gene name).

Condition Set 36

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 6; of these 6 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P08910 (ABHD2), Q5EA42 (ABHD2).

Condition Set 37

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q14032 (BAAT), Q86TX2 (ACOT1).

Condition Set 38

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q8WYK0 (ACOT12), Q8WXI4 (ACOT11).

Condition Set 39

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9Y570 (PPME1), Q4FZT2 (Ppme1).

Condition Set 40

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9SE93 (PNAE), P0DO81 (NS2).

Condition Set 41

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q8WZ82 (OVCA2), Q9D7E3 (Ovca2).

Condition Set 42

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q5BGN7 (ppe1), Q7SGG8 (pme-1).

Condition Set 43

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9Y305 (ACOT9), Q3SWX2 (ACOT9).

Condition Set 44

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9HAT2 (SIAE), P82450 (Siae).

Condition Set 45

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P0A8Z7 (yqiA), P0A8Z8 (yqiA).

Condition Set 46

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: O06319 (cut4), P9WP41 (cut2).

Condition Set 47

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: O42807 (faeA), Q9P979 (faeA).

Condition Set 48

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: E6MWF8 (bioH), Q9K197 (bioH).

Condition Set 49

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P19835 (CEL), Q64285 (Cel).

Condition Set 50

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q96SE0 (ABHD1), Q9QZC8 (Abhd1).

Condition Set 51

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P32750 (BCHE), P32753 (BCHE).

Condition Set 52

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: A0A0H2XJL0 (fphH), O32232 (est).

Condition Set 53

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9FX94 (CXE5), Q9SMN0 (CXE12).

Condition Set 54

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: O14734 (ACOT8), P58137 (Acot8).

Condition Set 55

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q99685 (MGLL), Q8R431 (Mgll).

Condition Set 56

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q8WU67 (ABHD3), Q0VC00 (ABHD3).

Condition Set 57

3 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q91V12 (Acot7), Q64559 (Acot7).

Condition Set 58

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q9S2A5 (no gene name), Q93MW7 (no gene name).

Condition Set 59

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P38295 (EHT1), Q02891 (EEB1).

Condition Set 60

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P9WM39 (no gene name), P9WM38 (no gene name).

Condition Set 61

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P21837 (cryS), P18142 (D2).

Condition Set 62

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q04457 (ges-1), Q04456 (ges-1).

Condition Set 63

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P0CO62 (PPE1), P0CO63 (PPE1).

Condition Set 64

2 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: P38433 (ace-1), Q27459 (ace-1).

Condition Set 65

1 condition(s)
Notes:

Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB query, 2026-11-10). Examples with the keyword: Q54T49 (no gene name), Q6CGL4 (no gene name).

Assessments

Raw YAML

View Source YAML 
id: ARBA00022487
description: >-
  Assigns the UniProt keyword KW-0719 (Serine esterase) through 65 alternative condition sets built from
  InterPro, PANTHER and CATH FunFam signatures.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00022487
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR000073
      curie: InterPro:IPR000073
      label: Alpha/beta hydrolase fold-1
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR010076
      curie: InterPro:IPR010076
      label: Pimeloyl-[acyl-carrier protein] methyl ester esterase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR029058
      curie: InterPro:IPR029058
      label: Alpha/Beta hydrolase fold
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 106; of these 106 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P13001 (bioH), Q8GHL1 (bioH).
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR010520
      curie: InterPro:IPR010520
      label: Esterase FrsA-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR043423
      curie: InterPro:IPR043423
      label: Esterase FrsA
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050261
      curie: InterPro:IPR050261
      label: FrsA/Cutinase/Hydrolase-like
      interpro_type: FAMILY
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 69; of these 69 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P04335 (frsA), Q8DF91 (frsA).
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR000675
      curie: InterPro:IPR000675
      label: Cutinase/acetylxylan esterase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR043580
      curie: InterPro:IPR043580
      label: Cutinase, serine active site
      interpro_type: CONSERVED_SITE
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 54; of these 54 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P9WP43 (cut7), A0A024SC78 (no gene name).
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR011150
      curie: InterPro:IPR011150
      label: Cutinase, monofunctional
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 47; of these 47 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: A0A024SC78 (no gene name), P11373 (CUTA).
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR043579
      curie: InterPro:IPR043579
      label: Cutinase, aspartate and histidine active sites
      interpro_type: CONSERVED_SITE
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 41; of these 41 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P9WP43 (cut7), P52956 (cutL1).
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR002018
      curie: InterPro:IPR002018
      label: Carboxylesterase, type B
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050654
      curie: InterPro:IPR050654
      label: Acetylcholinesterase-related enzymes
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 39; of these 39 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P22303 (ACHE), P06276 (BCHE).
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR000801
      curie: InterPro:IPR000801
      label: Esterase-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR014186
      curie: InterPro:IPR014186
      label: S-formylglutathione hydrolase
      interpro_type: FAMILY
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 38; of these 38 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P10768 (ESD), P33018 (yeiG).
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR013094
      curie: InterPro:IPR013094
      label: Alpha/beta hydrolase fold-3
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR023508
      curie: InterPro:IPR023508
      label: Acetyl esterase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR033140
      curie: InterPro:IPR033140
      label: Lipase, GDXG, putative serine active site
      interpro_type: ACTIVE_SITE
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 37; of these 37 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P23872 (aes), B5EXN3 (aes).
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR019826
      curie: InterPro:IPR019826
      label: Carboxylesterase type B, active site
      interpro_type: ACTIVE_SITE
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 32; of these 32 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P07140 (Ace), P38433 (ace-1).
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR016812
      curie: InterPro:IPR016812
      label: Protein phosphatase methylesterase, eukaryotic
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR14189:SF0
      curie: PANTHER:PTHR14189:SF0
      label: PROTEIN PHOSPHATASE METHYLESTERASE 1
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 22; of these 22 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: Q9Y570 (PPME1), Q4FZT2 (Ppme1).
  - number: 11
    conditions:
    - condition_type: INTERPRO
      value: IPR011118
      curie: InterPro:IPR011118
      label: Tannase/feruloyl esterase
      interpro_type: FAMILY
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 22; of these 22 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: A0A0K8P8E7 (no gene name), P78581 (no
      gene name).
  - number: 12
    conditions:
    - condition_type: PANTHER
      value: PTHR43142
      curie: PANTHER:PTHR43142
      label: CARBOXYLIC ESTER HYDROLASE
      negated: false
    - condition_type: PANTHER
      value: PTHR43142:SF1
      curie: PANTHER:PTHR43142:SF1
      label: CARBOXYLIC ESTER HYDROLASE
      negated: false
    - condition_type: TAXON
      value: Arthropoda
      curie: NCBITaxon:6656
      label: Arthropoda
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 18; of these 18 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P08171 (Est-6), P25726 (Est-5B).
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR010126
      curie: InterPro:IPR010126
      label: Esterase, PHB depolymerase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050955
      curie: InterPro:IPR050955
      label: Plant Biomass Hydrolyzing Esterase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 17; of these 17 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: G2QND5 (Fae1a), Q8NJP6 (axeA).
  - number: 14
    conditions:
    - condition_type: INTERPRO
      value: IPR000952
      curie: InterPro:IPR000952
      label: AB hydrolase 4, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR012020
      curie: InterPro:IPR012020
      label: AB hydrolase 4 family
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050960
      curie: InterPro:IPR050960
      label: AB hydrolase superfamily, subfamily 4
      interpro_type: FAMILY
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 16; of these 16 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P08910 (ABHD2), Q8WU67 (ABHD3).
  - number: 15
    conditions:
    - condition_type: PANTHER
      value: PTHR33630
      curie: PANTHER:PTHR33630
      label: CUTINASE RV1984C-RELATED-RELATED
      negated: false
    - condition_type: PANTHER
      value: PTHR33630:SF9
      curie: PANTHER:PTHR33630:SF9
      label: CUTINASE 4
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 16; of these 16 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: A6WFI5 (cut), P9WP43 (cut7).
  - number: 16
    conditions:
    - condition_type: INTERPRO
      value: IPR003140
      curie: InterPro:IPR003140
      label: Phospholipase/carboxylesterase/thioesterase
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR10655:SF17
      curie: PANTHER:PTHR10655:SF17
      label: LYSOPHOSPHOLIPASE-LIKE PROTEIN 1
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 15; of these 15 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: Q12354 (no gene name), O42881 (no gene
      name).
  - number: 17
    conditions:
    - condition_type: INTERPRO
      value: IPR054579
      curie: InterPro:IPR054579
      label: 4-O-methyl-glucuronoyl methylesterase-like domain
      interpro_type: DOMAIN
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 13; of these 13 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: A0A0A7EQR3 (no gene name), G0RV93 (cip2).
  - number: 18
    conditions:
    - condition_type: INTERPRO
      value: IPR041127
      curie: InterPro:IPR041127
      label: PET hydrolase/cutinase-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR22946:SF9
      curie: PANTHER:PTHR22946:SF9
      label: POLYKETIDE TRANSFERASE AF380
      negated: false
    - condition_type: TAXON
      value: Streptosporangiales
      curie: NCBITaxon:85012
      label: Streptosporangiales
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 8; of these 8 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: F7IX06 (est2), G8GER6 (cut_1).
  - number: 19
    conditions:
    - condition_type: INTERPRO
      value: IPR002921
      curie: InterPro:IPR002921
      label: Fungal lipase-type domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051299
      curie: InterPro:IPR051299
      label: Alpha/beta hydrolase lipase/esterase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Aspergillus
      curie: NCBITaxon:5052
      label: Aspergillus
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: O42807 (faeA), Q9P979 (faeA).
  - number: 20
    conditions:
    - condition_type: INTERPRO
      value: IPR029069
      curie: InterPro:IPR029069
      label: HotDog domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR033120
      curie: InterPro:IPR033120
      label: Hotdog acyl-CoA thioesterase (ACOT)-type domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q8VHQ9 (Acot11), Q91V12 (Acot7).
  - number: 21
    conditions:
    - condition_type: INTERPRO
      value: IPR022742
      curie: InterPro:IPR022742
      label: Alpha/beta hydrolase domain-containing protein 17C-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051044
      curie: InterPro:IPR051044
      label: Monoacylglycerol and Diacylglycerol Lipase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Bacillota
      curie: NCBITaxon:1239
      label: Bacillota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 6; of these 6 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P82597 (no gene name), A0A0H2XJL0 (fphH).
  - number: 22
    conditions:
    - condition_type: INTERPRO
      value: IPR002913
      curie: InterPro:IPR002913
      label: START domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006683
      curie: InterPro:IPR006683
      label: Thioesterase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR023393
      curie: InterPro:IPR023393
      label: START-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q8WYK0 (ACOT12), Q8WXI4 (ACOT11).
  - number: 23
    conditions:
    - condition_type: INTERPRO
      value: IPR006862
      curie: InterPro:IPR006862
      label: Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014940
      curie: InterPro:IPR014940
      label: BAAT/Acyl-CoA thioester hydrolase C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q14032 (BAAT), Q86TX2 (ACOT1).
  - number: 24
    conditions:
    - condition_type: INTERPRO
      value: IPR045889
      curie: InterPro:IPR045889
      label: Methylesterase/Alpha-hydroxynitrile lyase
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR10992:SF1083
      curie: PANTHER:PTHR10992:SF1083
      label: METHYLESTERASE 1
      negated: false
    - condition_type: TAXON
      value: Gentianales
      curie: NCBITaxon:4055
      label: Gentianales
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9SE93 (PNAE), P0DO80 (NS1).
  - number: 25
    conditions:
    - condition_type: PANTHER
      value: PTHR43798:SF33
      curie: PANTHER:PTHR43798:SF33
      label: HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED
      negated: false
    - condition_type: TAXON
      value: Mycoplasmatota
      curie: NCBITaxon:544448
      label: Mycoplasmatota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q49412 (no gene name), P75333 (no gene name).
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000022
      curie: CATH.FunFam:3.40.50.1820:FF:000022
      label: Esterase FrsA
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 56; of these 56 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P04335 (frsA), A8AKP9 (frsA).
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000045
      curie: CATH.FunFam:3.40.50.1820:FF:000045
      label: Pimeloyl-[acyl-carrier protein] methyl ester esterase
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 47; of these 47 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P13001 (bioH), Q8GHL1 (bioH).
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000235
      curie: CATH.FunFam:3.40.50.1820:FF:000235
      label: Cutinase 1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 38; of these 38 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P52956 (cutL1), Q5AVY9 (cut2).
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000035
      curie: CATH.FunFam:3.40.50.1820:FF:000035
      label: Acetyl esterase
      negated: false
    - condition_type: TAXON
      value: Pseudomonadota
      curie: NCBITaxon:1224
      label: Pseudomonadota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 37; of these 37 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P23872 (aes), B5EXN3 (aes).
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000002
      curie: CATH.FunFam:3.40.50.1820:FF:000002
      label: S-formylglutathione hydrolase
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 36; of these 36 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P10768 (ESD), P33018 (yeiG).
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000029
      curie: CATH.FunFam:3.40.50.1820:FF:000029
      label: Acetylcholinesterase
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 26; of these 26 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P22303 (ACHE), P06276 (BCHE).
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000378
      curie: CATH.FunFam:3.40.50.1820:FF:000378
      label: Carboxylic ester hydrolase
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 13; of these 13 carry KW-0719 Serine esterase
      (UniProtKB query, 2026-11-10). Examples with the keyword: P08171 (Est-6), P25726 (Est-5B).
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000011
      curie: CATH.FunFam:3.40.50.1820:FF:000011
      label: Carboxylic ester hydrolase
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: O00748 (CES2), P23141 (CES1).
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000203
      curie: CATH.FunFam:3.40.50.1820:FF:000203
      label: Feruloyl esterase B
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 7; of these 7 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9HE18 (FAEB), Q5B037 (axeA).
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000010
      curie: CATH.FunFam:3.40.50.1820:FF:000010
      label: Acyl-protein thioesterase 2
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 6; of these 6 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q4I8Q4 (no gene name), P0CL94 (no gene name).
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000053
      curie: CATH.FunFam:3.40.50.1820:FF:000053
      label: Abhydrolase domain containing 2
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 6; of these 6 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P08910 (ABHD2), Q5EA42 (ABHD2).
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.2240:FF:000001
      curie: CATH.FunFam:2.60.40.2240:FF:000001
      label: acyl-coenzyme A thioesterase 4
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q14032 (BAAT), Q86TX2 (ACOT1).
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 3.10.129.10:FF:000011
      curie: CATH.FunFam:3.10.129.10:FF:000011
      label: Acyl-coenzyme A thioesterase 11
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q8WYK0 (ACOT12), Q8WXI4 (ACOT11).
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000048
      curie: CATH.FunFam:3.40.50.1820:FF:000048
      label: Protein phosphatase methylesterase 1
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9Y570 (PPME1), Q4FZT2 (Ppme1).
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000051
      curie: CATH.FunFam:3.40.50.1820:FF:000051
      label: (S)-hydroxynitrile lyase
      negated: false
    - condition_type: TAXON
      value: Gentianales
      curie: NCBITaxon:4055
      label: Gentianales
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9SE93 (PNAE), P0DO81 (NS2).
  - number: 41
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000073
      curie: CATH.FunFam:3.40.50.1820:FF:000073
      label: esterase OVCA2 isoform X6
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q8WZ82 (OVCA2), Q9D7E3 (Ovca2).
  - number: 42
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000186
      curie: CATH.FunFam:3.40.50.1820:FF:000186
      label: Protein phosphatase methylesterase 1
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 5; of these 5 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q5BGN7 (ppe1), Q7SGG8 (pme-1).
  - number: 43
    conditions:
    - condition_type: FUNFAM
      value: 3.10.129.10:FF:000012
      curie: CATH.FunFam:3.10.129.10:FF:000012
      label: Acyl-coenzyme A thioesterase 9, mitochondrial
      negated: false
    - condition_type: FUNFAM
      value: 3.10.129.10:FF:000016
      curie: CATH.FunFam:3.10.129.10:FF:000016
      label: Acyl-coenzyme A thioesterase 9, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9Y305 (ACOT9), Q3SWX2 (ACOT9).
  - number: 44
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1110:FF:000008
      curie: CATH.FunFam:3.40.50.1110:FF:000008
      label: Sialate O-acetylesterase
      negated: false
    - condition_type: TAXON
      value: Eutheria
      curie: NCBITaxon:9347
      label: Eutheria
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9HAT2 (SIAE), P82450 (Siae).
  - number: 45
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000027
      curie: CATH.FunFam:3.40.50.1820:FF:000027
      label: Esterase YqiA
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P0A8Z7 (yqiA), P0A8Z8 (yqiA).
  - number: 46
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000176
      curie: CATH.FunFam:3.40.50.1820:FF:000176
      label: Cutinase Cut4
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: O06319 (cut4), P9WP41 (cut2).
  - number: 47
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000260
      curie: CATH.FunFam:3.40.50.1820:FF:000260
      label: Feruloyl esterase A
      negated: false
    - condition_type: TAXON
      value: Pezizomycotina
      curie: NCBITaxon:147538
      label: Pezizomycotina
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: O42807 (faeA), Q9P979 (faeA).
  - number: 48
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000523
      curie: CATH.FunFam:3.40.50.1820:FF:000523
      label: Pimeloyl-[acyl-carrier protein] methyl ester esterase
      negated: false
    - condition_type: TAXON
      value: Betaproteobacteria
      curie: NCBITaxon:28216
      label: Betaproteobacteria
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: E6MWF8 (bioH), Q9K197 (bioH).
  - number: 49
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000100
      curie: CATH.FunFam:3.40.50.1820:FF:000100
      label: Carboxylic ester hydrolase
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P19835 (CEL), Q64285 (Cel).
  - number: 50
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000167
      curie: CATH.FunFam:3.40.50.1820:FF:000167
      label: Abhydrolase domain containing 1
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q96SE0 (ABHD1), Q9QZC8 (Abhd1).
  - number: 51
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000598
      curie: CATH.FunFam:3.40.50.1820:FF:000598
      label: Cholinesterase
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4; of these 4 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P32750 (BCHE), P32753 (BCHE).
  - number: 52
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000070
      curie: CATH.FunFam:3.40.50.1820:FF:000070
      label: Carboxylesterase
      negated: false
    - condition_type: TAXON
      value: Bacillota
      curie: NCBITaxon:1239
      label: Bacillota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: A0A0H2XJL0 (fphH), O32232 (est).
  - number: 53
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000376
      curie: CATH.FunFam:3.40.50.1820:FF:000376
      label: Probable carboxylesterase 12
      negated: false
    - condition_type: TAXON
      value: malvids
      curie: NCBITaxon:91836
      label: malvids
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9FX94 (CXE5), Q9SMN0 (CXE12).
  - number: 54
    conditions:
    - condition_type: FUNFAM
      value: 2.40.160.210:FF:000002
      curie: CATH.FunFam:2.40.160.210:FF:000002
      label: acyl-coenzyme A thioesterase 8
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: O14734 (ACOT8), P58137 (Acot8).
  - number: 55
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000066
      curie: CATH.FunFam:3.40.50.1820:FF:000066
      label: Monoglyceride lipase
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q99685 (MGLL), Q8R431 (Mgll).
  - number: 56
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000079
      curie: CATH.FunFam:3.40.50.1820:FF:000079
      label: Abhydrolase domain-containing 3
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 3; of these 3 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q8WU67 (ABHD3), Q0VC00 (ABHD3).
  - number: 57
    conditions:
    - condition_type: FUNFAM
      value: 3.10.129.10:FF:000009
      curie: CATH.FunFam:3.10.129.10:FF:000009
      label: Cytosolic acyl coenzyme A thioester hydrolase
      negated: false
    - condition_type: FUNFAM
      value: 3.10.129.10:FF:000010
      curie: CATH.FunFam:3.10.129.10:FF:000010
      label: Cytosolic acyl coenzyme A thioester hydrolase
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q91V12 (Acot7), Q64559 (Acot7).
  - number: 58
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1110:FF:000018
      curie: CATH.FunFam:3.40.50.1110:FF:000018
      label: Lipase 1
      negated: false
    - condition_type: TAXON
      value: Actinomycetota
      curie: NCBITaxon:201174
      label: Actinomycetota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q9S2A5 (no gene name), Q93MW7 (no gene name).
  - number: 59
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000137
      curie: CATH.FunFam:3.40.50.1820:FF:000137
      label: EEB1p Acyl-coenzymeA:ethanol O-acyltransferase
      negated: false
    - condition_type: TAXON
      value: Saccharomycotina
      curie: NCBITaxon:147537
      label: Saccharomycotina
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P38295 (EHT1), Q02891 (EEB1).
  - number: 60
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000198
      curie: CATH.FunFam:3.40.50.1820:FF:000198
      label: Putative esterase
      negated: false
    - condition_type: TAXON
      value: Actinomycetes
      curie: NCBITaxon:1760
      label: Actinomycetes
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P9WM39 (no gene name), P9WM38 (no gene name).
  - number: 61
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000293
      curie: CATH.FunFam:3.40.50.1820:FF:000293
      label: Carboxylic ester hydrolase
      negated: false
    - condition_type: TAXON
      value: Amoebozoa
      curie: NCBITaxon:554915
      label: Amoebozoa
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P21837 (cryS), P18142 (D2).
  - number: 62
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000317
      curie: CATH.FunFam:3.40.50.1820:FF:000317
      label: Carboxylic ester hydrolase
      negated: false
    - condition_type: TAXON
      value: Nematoda
      curie: NCBITaxon:6231
      label: Nematoda
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q04457 (ges-1), Q04456 (ges-1).
  - number: 63
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000412
      curie: CATH.FunFam:3.40.50.1820:FF:000412
      label: Protein phosphatase methylesterase 1
      negated: false
    - condition_type: TAXON
      value: Basidiomycota
      curie: NCBITaxon:5204
      label: Basidiomycota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P0CO62 (PPE1), P0CO63 (PPE1).
  - number: 64
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000476
      curie: CATH.FunFam:3.40.50.1820:FF:000476
      label: Carboxylic ester hydrolase
      negated: false
    - condition_type: TAXON
      value: Chromadorea
      curie: NCBITaxon:119089
      label: Chromadorea
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: P38433 (ace-1), Q27459 (ace-1).
  - number: 65
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000276
      curie: CATH.FunFam:3.40.50.1820:FF:000276
      label: Acyl-protein thioesterase 1
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2; of these 2 carry KW-0719 Serine esterase (UniProtKB
      query, 2026-11-10). Examples with the keyword: Q54T49 (no gene name), Q6CGL4 (no gene name).
  go_annotations: []
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 83725
  created_date: '2020-05-12'
  modified_date: '2026-07-18'
  source_condition_set_count: 65
  retrieved_date: '2026-11-09'
review_summary: >-
  All 65 live condition sets were screened with two UniProtKB queries each (2026-11-10): the Swiss-Prot
  entries that match the whole conjunction, and how many of them carry KW-0719 Serine esterase. Every
  set matches at least one Swiss-Prot entry. Summed over sets there are 1,028 set-level matches (an entry
  that matches several sets is counted once per set) and 1,028 of them carry the keyword. No set has a
  Swiss-Prot match without the keyword. All 65 sets are recorded in the rule block with official signature
  names. 46 of the 65 sets have a taxon condition. ARBA rules are mined from Swiss-Prot annotation, so
  this screen shows that no set conflicts with curated keywords; it does not measure precision on the
  83,725 unreviewed entries the rule annotates.
action: ACCEPT
action_rationale: >-
  The keyword Serine esterase is defined by UniProt as: Enzyme which catalyzes the hydrolysis of esters
  and is characterized by a catalytically active serine residue in its active site. It is a class label,
  so its members are expected to be diverse. In every one of the 65 condition sets all Swiss-Prot matches
  carry the keyword. The rule emits a keyword, not a GO term; UniProt maps KW-0719 to GO:0052689 carboxylic
  ester hydrolase activity. Confidence is moderate because the evidence is agreement with Swiss-Prot,
  the source ARBA rules are mined from, and precision on unreviewed entries was not measured.
annotation_assessments:
- annotation_kind: KEYWORD
  value: KW-0719
  label: Serine esterase
  assessment: CORRECT
  correct_examples:
  - P13001
  - Q8GHL1
  - P04335
  - Q8DF91
  - P9WP43
  - A0A024SC78
  - P11373
  - P52956
  notes: >-
    UniProt keyword KW-0719 definition: Enzyme which catalyzes the hydrolysis of esters and is characterized
    by a catalytically active serine residue in its active site. UniProt keyword-to-GO mapping: GO:0052689
    carboxylic ester hydrolase activity. Set-level Swiss-Prot matches 1,028; with the keyword 1,028. The
    examples are Swiss-Prot entries that match a recorded condition set and carry the keyword.
confidence: 0.6
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    Literature contradicts grouping these hydrolases, citing https://doi.org/10.1038/s41598-017-01691-x
    and https://doi.org/10.1016/j.chemphys.2013.08.015 with quoted text.
  correction: >-
    Neither citation supports the claim: one DOI is not registered and the other is an unrelated physics
    paper, so the quoted sentences are not from those sources. The block was removed.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    doi.org handle API for 10.1038/s41598-017-01691-x: responseCode 100 (handle not found); Crossref returns
    HTTP 404
  - >-
    Crossref title for 10.1016/j.chemphys.2013.08.015: Sub-THz spectroscopic characterization of vibrational
    modes in artificially designed DNA monocrystal (Chemical Physics)
- date: '2026-11-10'
  withdrawn_claim: >-
    The keyword conflates cutinases, lipases, carboxylesterases and acetylcholinesterases, so the rule
    should be removed.
  correction: >-
    All of those families are serine esterases by the UniProt definition of the keyword; a correct class
    label is not made wrong by the diversity of its members.
  error_type: GENERAL_IS_NOT_WRONG
  evidence:
  - >-
    UniProt KW-0719 definition: Enzyme which catalyzes the hydrolysis of esters and is characterized by
    a catalytically active serine residue in its active site.
  - >-
    All 1,028 set-level Swiss-Prot matches of the 65 live sets carry KW-0719 (UniProtKB, 2026-11-10)
- date: '2026-11-10'
  withdrawn_claim: >-
    62 condition sets suggest over-fitting, and the rule complexity makes it prone to false positives.
  correction: >-
    The number of condition sets is not evidence about correctness, and no false positive was shown.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - No Swiss-Prot match of any of the 65 live sets lacks the keyword
- date: '2026-11-10'
  withdrawn_claim: >-
    The conclusion was reached although the analysis was skipped and no condition set was recorded.
  correction: The live sets were read and screened one by one.
  error_type: UNEXAMINED_RULE
  evidence:
  - >-
    Previous version: condition_sets [] and the finding "Analysis skipped due to excessive complexity"
  - 'Live rule: 65 condition sets, 46 with a taxon condition'
- date: '2026-11-10'
  withdrawn_claim: GO:0008849 is cutinase activity.
  correction: GO:0008849 is enterochelin esterase activity.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'QuickGO GO:0008849 label: enterochelin esterase activity'
  - QuickGO GO:0004091 is a secondary id of GO:0052689 carboxylic ester hydrolase activity
- date: '2026-11-10'
  withdrawn_claim: Supporting files ARBA00022487.enriched.json and ARBA00022487-analysis.yaml were cited.
  correction: >-
    Neither file is in the rule folder; the other source was the rule's own manual note. The references
    were removed.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    rules/arba/ARBA00022487/ contains only the deep-research-manual note, the review YAML and its HTML
    rendering