ARBA00022722

id: ARBA00022722
description: Assigns the UniProt keyword Nuclease (KW-0540) through 538 alternative condition sets built from InterPro
  entries, PANTHER families and CATH FunFams. 326 sets are conjunctions of two or more conditions and 153 carry
  a taxon condition.
status: IN_PROGRESS
rule_type: ARBA
rule:
  rule_id: ARBA00022722
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR001352
      curie: InterPro:IPR001352
      label: Ribonuclease HII/HIII
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR012337
      curie: InterPro:IPR012337
      label: Ribonuclease H-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR024567
      curie: InterPro:IPR024567
      label: Ribonuclease HII/HIII domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 797 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 24176.'
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR002036
      curie: InterPro:IPR002036
      label: Endoribonuclease YbeY
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023091
      curie: InterPro:IPR023091
      label: Metalloprotease catalytic domain superfamily, predicted
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 711 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 20141.'
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR005227
      curie: InterPro:IPR005227
      label: Nuclease YqgF
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR006641
      curie: InterPro:IPR006641
      label: YqgF/RNase H-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR037027
      curie: InterPro:IPR037027
      label: YqgF/RNase H-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 610 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 19019.'
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR002176
      curie: InterPro:IPR002176
      label: Crossover junction endodeoxyribonuclease RuvC
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR30194:SF3
      curie: PANTHER:PTHR30194:SF3
      label: CROSSOVER JUNCTION ENDODEOXYRIBONUCLEASE RUVC
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 546 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 16162.'
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR000100
      curie: InterPro:IPR000100
      label: Ribonuclease P
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR014721
      curie: InterPro:IPR014721
      label: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR020568
      curie: InterPro:IPR020568
      label: Ribosomal protein uS5 domain 2-type superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 507 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 17322.'
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR000999
      curie: InterPro:IPR000999
      label: Ribonuclease III domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR011907
      curie: InterPro:IPR011907
      label: Ribonuclease III
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036389
      curie: InterPro:IPR036389
      label: Ribonuclease III, endonuclease domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 506 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 20448.'
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR014720
      curie: InterPro:IPR014720
      label: Double-stranded RNA-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR11207
      curie: PANTHER:PTHR11207
      label: RIBONUCLEASE III
      negated: false
    - condition_type: PANTHER
      value: PTHR11207:SF0
      curie: PANTHER:PTHR11207:SF0
      label: RIBONUCLEASE 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 486. 486 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 20207.'
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR003761
      curie: InterPro:IPR003761
      label: Exonuclease VII, small subunit
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR037004
      curie: InterPro:IPR037004
      label: Exonuclease VII, small subunit superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR34137:SF1
      curie: PANTHER:PTHR34137:SF1
      label: EXODEOXYRIBONUCLEASE 7 SMALL SUBUNIT
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 433. 433 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 15829.'
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR003753
      curie: InterPro:IPR003753
      label: Exonuclease VII, large subunit
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR020579
      curie: InterPro:IPR020579
      label: Exonuclease VII, large subunit, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR025824
      curie: InterPro:IPR025824
      label: OB-fold nucleic acid binding domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 420. 420 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 16367.'
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR002156
      curie: InterPro:IPR002156
      label: Ribonuclease H domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050092
      curie: InterPro:IPR050092
      label: Ribonuclease H
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR10642:SF26
      curie: PANTHER:PTHR10642:SF26
      label: RIBONUCLEASE H1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 341. 341 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 28319.'
  - number: 11
    conditions:
    - condition_type: INTERPRO
      value: IPR013471
      curie: InterPro:IPR013471
      label: Ribonuclease Z/BN
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036866
      curie: InterPro:IPR036866
      label: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 315. 315 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 10758.'
  - number: 12
    conditions:
    - condition_type: INTERPRO
      value: IPR027417
      curie: InterPro:IPR027417
      label: P-loop containing nucleoside triphosphate hydrolase
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR038726
      curie: InterPro:IPR038726
      label: PD-(D/E)XK endonuclease-like domain, AddAB-type
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 269. 269 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 15472.'
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR006084
      curie: InterPro:IPR006084
      label: XPG/Rad2 endonuclease
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR006085
      curie: InterPro:IPR006085
      label: XPG, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR036279
      curie: InterPro:IPR036279
      label: 5'-3' exonuclease, C-terminal domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 221. 221 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 16240.'
  - number: 14
    conditions:
    - condition_type: INTERPRO
      value: IPR006674
      curie: InterPro:IPR006674
      label: HD domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006675
      curie: InterPro:IPR006675
      label: HDIG domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR017705
      curie: InterPro:IPR017705
      label: Ribonuclease Y
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 220. 220 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7445.'
  - number: 15
    conditions:
    - condition_type: INTERPRO
      value: IPR011604
      curie: InterPro:IPR011604
      label: PD-(D/E)XK endonuclease-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR014017
      curie: InterPro:IPR014017
      label: UvrD-like helicase, C-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 206. 206 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 22941.'
  - number: 16
    conditions:
    - condition_type: INTERPRO
      value: IPR043128
      curie: InterPro:IPR043128
      label: Reverse transcriptase/Diguanylate cyclase domain
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Pararnavirae
      curie: NCBITaxon:2732397
      label: Pararnavirae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 204. 204 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 30704.'
  - number: 17
    conditions:
    - condition_type: INTERPRO
      value: IPR013520
      curie: InterPro:IPR013520
      label: Ribonuclease H-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 203. 203 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 17388.'
  - number: 18
    conditions:
    - condition_type: INTERPRO
      value: IPR001427
      curie: InterPro:IPR001427
      label: Pancreatic ribonuclease
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023411
      curie: InterPro:IPR023411
      label: Ribonuclease A, active site
      interpro_type: ACTIVE_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR023412
      curie: InterPro:IPR023412
      label: Ribonuclease A-domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 189. 189 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2477.'
  - number: 19
    conditions:
    - condition_type: PANTHER
      value: PTHR11081:SF9
      curie: PANTHER:PTHR11081:SF9
      label: FLAP ENDONUCLEASE 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 188. 188 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 5604.'
  - number: 20
    conditions:
    - condition_type: INTERPRO
      value: IPR022894
      curie: InterPro:IPR022894
      label: Oligoribonuclease
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 176. 176 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 16490.'
  - number: 21
    conditions:
    - condition_type: INTERPRO
      value: IPR001584
      curie: InterPro:IPR001584
      label: Integrase, catalytic core
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR001969
      curie: InterPro:IPR001969
      label: Aspartic peptidase, active site
      interpro_type: ACTIVE_SITE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 155. 155 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 9907.'
  - number: 22
    conditions:
    - condition_type: PANTHER
      value: PTHR30591
      curie: PANTHER:PTHR30591
      label: RECBCD ENZYME SUBUNIT RECC
      negated: false
    - condition_type: PANTHER
      value: PTHR30591:SF1
      curie: PANTHER:PTHR30591:SF1
      label: RECBCD ENZYME SUBUNIT RECC
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 144. 144 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 8827.'
  - number: 23
    conditions:
    - condition_type: INTERPRO
      value: IPR014152
      curie: InterPro:IPR014152
      label: ATP-dependent helicase/nuclease subunit A
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR11070:SF48
      curie: PANTHER:PTHR11070:SF48
      label: ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A
      negated: false
    - condition_type: TAXON
      value: Bacillota
      curie: NCBITaxon:1239
      label: Bacillota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 140. 140 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2787.'
  - number: 24
    conditions:
    - condition_type: INTERPRO
      value: IPR007581
      curie: InterPro:IPR007581
      label: Endonuclease V
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR28511:SF1
      curie: PANTHER:PTHR28511:SF1
      label: ENDONUCLEASE V
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 131. 131 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7006.'
  - number: 25
    conditions:
    - condition_type: INTERPRO
      value: IPR022907
      curie: InterPro:IPR022907
      label: VapC family
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 123. 123 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 20356.'
  - number: 26
    conditions:
    - condition_type: INTERPRO
      value: IPR001900
      curie: InterPro:IPR001900
      label: Ribonuclease II/R
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR004476
      curie: InterPro:IPR004476
      label: Ribonuclease II/ribonuclease R
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR012340
      curie: InterPro:IPR012340
      label: Nucleic acid-binding, OB-fold
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 113. 113 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 13973.'
  - number: 27
    conditions:
    - condition_type: INTERPRO
      value: IPR020046
      curie: InterPro:IPR020046
      label: 5'-3' exonuclease, alpha-helical arch, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR038969
      curie: InterPro:IPR038969
      label: Flap endonuclease
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR42646:SF2
      curie: PANTHER:PTHR42646:SF2
      label: 5'-3' EXONUCLEASE FAMILY PROTEIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 113. 113 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 8626.'
  - number: 28
    conditions:
    - condition_type: INTERPRO
      value: IPR011129
      curie: InterPro:IPR011129
      label: Cold-shock domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050180
      curie: InterPro:IPR050180
      label: RNR Ribonuclease
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 111. 111 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 9402.'
  - number: 29
    conditions:
    - condition_type: INTERPRO
      value: IPR013223
      curie: InterPro:IPR013223
      label: Ribonuclease B, N-terminal OB domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 110. 110 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 11447.'
  - number: 30
    conditions:
    - condition_type: PANTHER
      value: PTHR41694
      curie: PANTHER:PTHR41694
      label: ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 110. 110 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 21087.'
  - number: 31
    conditions:
    - condition_type: INTERPRO
      value: IPR002421
      curie: InterPro:IPR002421
      label: 5'-3' exonuclease
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR020045
      curie: InterPro:IPR020045
      label: DNA polymerase I-like, H3TH domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Pseudomonadota
      curie: NCBITaxon:1224
      label: Pseudomonadota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 108. 108 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 8503.'
  - number: 32
    conditions:
    - condition_type: INTERPRO
      value: IPR001009
      curie: InterPro:IPR001009
      label: Influenza RNA-dependent RNA polymerase subunit PA
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR037534
      curie: InterPro:IPR037534
      label: Polymerase acidic protein
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR038372
      curie: InterPro:IPR038372
      label: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 102. 102 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1879.'
  - number: 33
    conditions:
    - condition_type: INTERPRO
      value: IPR003029
      curie: InterPro:IPR003029
      label: S1 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR022966
      curie: InterPro:IPR022966
      label: Ribonuclease II/R, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 100. 100 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 12969.'
  - number: 34
    conditions:
    - condition_type: INTERPRO
      value: IPR002716
      curie: InterPro:IPR002716
      label: PIN domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Actinomycetota
      curie: NCBITaxon:201174
      label: Actinomycetota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 96. 96 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 16841.'
  - number: 35
    conditions:
    - condition_type: INTERPRO
      value: IPR037057
      curie: InterPro:IPR037057
      label: DNA mismatch repair MutH/Type II restriction endonuclease superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 95. 95 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2537.'
  - number: 36
    conditions:
    - condition_type: INTERPRO
      value: IPR002625
      curie: InterPro:IPR002625
      label: Smr domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR022990
      curie: InterPro:IPR022990
      label: Ribosome rescue factor SmrB
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036063
      curie: InterPro:IPR036063
      label: Smr domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 85. 85 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1293.'
  - number: 37
    conditions:
    - condition_type: INTERPRO
      value: IPR016071
      curie: InterPro:IPR016071
      label: Staphylococcal nuclease (SNase-like), OB-fold
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR035437
      curie: InterPro:IPR035437
      label: SNase-like, OB-fold superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR12302:SF3
      curie: PANTHER:PTHR12302:SF3
      label: SERINE_THREONINE-PROTEIN KINASE 31
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 80. 80 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 9838.'
  - number: 38
    conditions:
    - condition_type: INTERPRO
      value: IPR019199
      curie: InterPro:IPR019199
      label: Virulence-associated protein D / CRISPR associated protein Cas2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 78. 78 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6657.'
  - number: 39
    conditions:
    - condition_type: INTERPRO
      value: IPR021127
      curie: InterPro:IPR021127
      label: CRISPR-associated endonuclease Cas2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 75. 75 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6583.'
  - number: 40
    conditions:
    - condition_type: INTERPRO
      value: IPR049912
      curie: InterPro:IPR049912
      label: CRESS-DNA virus replication initiator protein, endonuclease domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 72. 72 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4706.'
  - number: 41
    conditions:
    - condition_type: INTERPRO
      value: IPR001719
      curie: InterPro:IPR001719
      label: AP endonuclease 2
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR21445:SF0
      curie: PANTHER:PTHR21445:SF0
      label: APURINIC-APYRIMIDINIC ENDONUCLEASE
      negated: false
    - condition_type: TAXON
      value: Enterobacterales
      curie: NCBITaxon:91347
      label: Enterobacterales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 71. 71 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 564.'
  - number: 42
    conditions:
    - condition_type: INTERPRO
      value: IPR000305
      curie: InterPro:IPR000305
      label: GIY-YIG endonuclease
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR027520
      curie: InterPro:IPR027520
      label: Structure-specific endonuclease subunit Slx1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR035901
      curie: InterPro:IPR035901
      label: GIY-YIG endonuclease superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 66. 66 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2647.'
  - number: 43
    conditions:
    - condition_type: INTERPRO
      value: IPR003141
      curie: InterPro:IPR003141
      label: Polymerase/histidinol phosphatase, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR004805
      curie: InterPro:IPR004805
      label: Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR006054
      curie: InterPro:IPR006054
      label: DNA polymerase III epsilon subunit, exonuclease domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 65. 65 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3243.'
  - number: 44
    conditions:
    - condition_type: INTERPRO
      value: IPR004405
      curie: InterPro:IPR004405
      label: Pelota
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR005140
      curie: InterPro:IPR005140
      label: eRF1/Pelota-like, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR023521
      curie: InterPro:IPR023521
      label: Pelota, archaea
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 63. 63 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 599.'
  - number: 45
    conditions:
    - condition_type: INTERPRO
      value: IPR004612
      curie: InterPro:IPR004612
      label: Holliday junction resolvase RecU
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR011856
      curie: InterPro:IPR011856
      label: tRNA endonuclease-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Lactobacillales
      curie: NCBITaxon:186826
      label: Lactobacillales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 59. 59 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 760.'
  - number: 46
    conditions:
    - condition_type: INTERPRO
      value: IPR002793
      curie: InterPro:IPR002793
      label: Endonuclease NucS
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR048301
      curie: InterPro:IPR048301
      label: Endonuclease NucS, C-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR048302
      curie: InterPro:IPR048302
      label: Endonuclease NucS, N-terminal PH-like domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 56. 56 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4333.'
  - number: 47
    conditions:
    - condition_type: INTERPRO
      value: IPR002729
      curie: InterPro:IPR002729
      label: CRISPR-associated protein Cas1
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 56. 56 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 9001.'
  - number: 48
    conditions:
    - condition_type: INTERPRO
      value: IPR047021
      curie: InterPro:IPR047021
      label: RNA exonuclease REXO1/REXO3/REXO4-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 55. 55 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 17711.'
  - number: 49
    conditions:
    - condition_type: INTERPRO
      value: IPR013022
      curie: InterPro:IPR013022
      label: Xylose isomerase-like, TIM barrel domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018246
      curie: InterPro:IPR018246
      label: AP endonuclease 2, zinc binding site
      interpro_type: BINDING_SITE
      negated: false
    - condition_type: TAXON
      value: Caryophanales
      curie: NCBITaxon:1385
      label: Caryophanales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 51. 51 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1786.'
  - number: 50
    conditions:
    - condition_type: INTERPRO
      value: IPR039537
      curie: InterPro:IPR039537
      label: Retrotransposon Ty1/copia-like
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR42648:SF11
      curie: PANTHER:PTHR42648:SF11
      label: TRANSPOSON TY4-P GAG-POL POLYPROTEIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 49. 49 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 15433.'
  - number: 51
    conditions:
    - condition_type: INTERPRO
      value: IPR050556
      curie: InterPro:IPR050556
      label: Type II toxin-antitoxin system RNase
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR33653:SF1
      curie: PANTHER:PTHR33653:SF1
      label: RIBONUCLEASE VAPC2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 47. 47 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 21294.'
  - number: 52
    conditions:
    - condition_type: INTERPRO
      value: IPR001279
      curie: InterPro:IPR001279
      label: Metallo-beta-lactamase
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR042173
      curie: InterPro:IPR042173
      label: Ribonuclease J, domain 2
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR055132
      curie: InterPro:IPR055132
      label: Ribonuclease J, beta-CASP domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 46. 46 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 15305.'
  - number: 53
    conditions:
    - condition_type: INTERPRO
      value: IPR004843
      curie: InterPro:IPR004843
      label: Calcineurin-like, phosphoesterase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR041796
      curie: InterPro:IPR041796
      label: DNA double-strand break repair protein Mre11, N-terminal metallophosphatase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR30337:SF0
      curie: PANTHER:PTHR30337:SF0
      label: NUCLEASE SBCCD SUBUNIT D
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 42. 42 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 11496.'
  - number: 54
    conditions:
    - condition_type: INTERPRO
      value: IPR016432
      curie: InterPro:IPR016432
      label: Ribonuclease P subunit RNP4
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 41. 41 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 684.'
  - number: 55
    conditions:
    - condition_type: INTERPRO
      value: IPR009461
      curie: InterPro:IPR009461
      label: Non-structural protein NSP16, coronavirus-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR029063
      curie: InterPro:IPR029063
      label: S-adenosyl-L-methionine-dependent methyltransferase superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR043609
      curie: InterPro:IPR043609
      label: NendoU domain, nidovirus
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 35. 35 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 977.'
  - number: 56
    conditions:
    - condition_type: INTERPRO
      value: IPR002730
      curie: InterPro:IPR002730
      label: Ribonuclease P protein subunit Rpp29/RNP1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023534
      curie: InterPro:IPR023534
      label: Rof/RNase P-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023538
      curie: InterPro:IPR023538
      label: Ribonuclease P protein subunit RNP1
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 34. 34 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1547.'
  - number: 57
    conditions:
    - condition_type: INTERPRO
      value: IPR004859
      curie: InterPro:IPR004859
      label: Xrn1, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR027073
      curie: InterPro:IPR027073
      label: 5'-3' exoribonuclease
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR041412
      curie: InterPro:IPR041412
      label: Xrn1, helical domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 34. 34 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 9650.'
  - number: 58
    conditions:
    - condition_type: INTERPRO
      value: IPR046436
      curie: InterPro:IPR046436
      label: Nidovirus 3'-5' exoribonuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Pisuviricota
      curie: NCBITaxon:2732408
      label: Pisuviricota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 34. 34 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1671.'
  - number: 59
    conditions:
    - condition_type: INTERPRO
      value: IPR000432
      curie: InterPro:IPR000432
      label: DNA mismatch repair protein MutS, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR005747
      curie: InterPro:IPR005747
      label: Endonuclease MutS2
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Streptococcaceae
      curie: NCBITaxon:1300
      label: Streptococcaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 33. 33 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 177.'
  - number: 60
    conditions:
    - condition_type: INTERPRO
      value: IPR001130
      curie: InterPro:IPR001130
      label: 3'-5' ssDNA/RNA exonuclease TatD-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR032466
      curie: InterPro:IPR032466
      label: Metal-dependent hydrolase
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050891
      curie: InterPro:IPR050891
      label: TatD-type Metallo-dependent Hydrolase
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 33. 33 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7095.'
  - number: 61
    conditions:
    - condition_type: INTERPRO
      value: IPR001611
      curie: InterPro:IPR001611
      label: Leucine-rich repeat
      interpro_type: REPEAT
      negated: false
    - condition_type: INTERPRO
      value: IPR003591
      curie: InterPro:IPR003591
      label: Leucine-rich repeat, typical subtype
      interpro_type: REPEAT
      negated: false
    - condition_type: INTERPRO
      value: IPR005135
      curie: InterPro:IPR005135
      label: Endonuclease/exonuclease/phosphatase
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 33. 33 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3616.'
  - number: 62
    conditions:
    - condition_type: INTERPRO
      value: IPR044863
      curie: InterPro:IPR044863
      label: Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050534
      curie: InterPro:IPR050534
      label: Replicase polyprotein 1ab-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Pisoniviricetes
      curie: NCBITaxon:2732506
      label: Pisoniviricetes
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 33. 33 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 990.'
  - number: 63
    conditions:
    - condition_type: INTERPRO
      value: IPR014856
      curie: InterPro:IPR014856
      label: RNA-free ribonuclease P
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR41173:SF1
      curie: PANTHER:PTHR41173:SF1
      label: RNA-FREE RIBONUCLEASE P
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 33. 33 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 327.'
  - number: 64
    conditions:
    - condition_type: INTERPRO
      value: IPR004475
      curie: InterPro:IPR004475
      label: DNA polymerase II large subunit DP2
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR016033
      curie: InterPro:IPR016033
      label: DNA polymerase II large subunit DP2, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR056171
      curie: InterPro:IPR056171
      label: DNA polymerase II large subunit DP2, central domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 32. 32 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 538.'
  - number: 65
    conditions:
    - condition_type: INTERPRO
      value: IPR015943
      curie: InterPro:IPR015943
      label: WD40/YVTN repeat-like-containing domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR028881
      curie: InterPro:IPR028881
      label: PAN2, UCH domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR030843
      curie: InterPro:IPR030843
      label: PAN2-PAN3 deadenylation complex catalytic subunit PAN2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 31. 31 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2643.'
  - number: 66
    conditions:
    - condition_type: INTERPRO
      value: IPR007295
      curie: InterPro:IPR007295
      label: Cytidylyl-2-hydroxypropylphosphonate hydrolase FomD-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR016730
      curie: InterPro:IPR016730
      label: RNA-binding FAU-1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR035930
      curie: InterPro:IPR035930
      label: FomD-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 340.'
  - number: 67
    conditions:
    - condition_type: INTERPRO
      value: IPR020873
      curie: InterPro:IPR020873
      label: 3'-5' exoribonuclease YhaM
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050798
      curie: InterPro:IPR050798
      label: YhaM family exoribonucleases and phosphodiesterases
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR37294:SF1
      curie: PANTHER:PTHR37294:SF1
      label: 3'-5' EXORIBONUCLEASE YHAM
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 274.'
  - number: 68
    conditions:
    - condition_type: INTERPRO
      value: IPR036187
      curie: InterPro:IPR036187
      label: DNA mismatch repair protein MutS, core domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR48466:SF2
      curie: PANTHER:PTHR48466:SF2
      label: OS10G0509000 PROTEIN
      negated: false
    - condition_type: TAXON
      value: Clostridia
      curie: NCBITaxon:186801
      label: Clostridia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1115.'
  - number: 69
    conditions:
    - condition_type: INTERPRO
      value: IPR016191
      curie: InterPro:IPR016191
      label: Ribonuclease/ribotoxin
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7827.'
  - number: 70
    conditions:
    - condition_type: INTERPRO
      value: IPR021109
      curie: InterPro:IPR021109
      label: Aspartic peptidase domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR37984
      curie: PANTHER:PTHR37984
      label: PROTEIN CBG26694
      negated: false
    - condition_type: PANTHER
      value: PTHR37984:SF5
      curie: PANTHER:PTHR37984:SF5
      label: PROTEIN NYNRIN-LIKE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 26. 26 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 35507.'
  - number: 71
    conditions:
    - condition_type: INTERPRO
      value: IPR018228
      curie: InterPro:IPR018228
      label: Deoxyribonuclease, TatD-related, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR024918
      curie: InterPro:IPR024918
      label: 3'-5' ssDNA/RNA exonuclease TatD
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 26. 26 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 445.'
  - number: 72
    conditions:
    - condition_type: INTERPRO
      value: IPR001247
      curie: InterPro:IPR001247
      label: Exoribonuclease, phosphorolytic domain 1
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR011807
      curie: InterPro:IPR011807
      label: Exosome complex component Rrp41
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR015847
      curie: InterPro:IPR015847
      label: Exoribonuclease, phosphorolytic domain 2
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 24. 24 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 275.'
  - number: 73
    conditions:
    - condition_type: INTERPRO
      value: IPR016202
      curie: InterPro:IPR016202
      label: Deoxyribonuclease I
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR11371
      curie: PANTHER:PTHR11371
      label: DEOXYRIBONUCLEASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 24. 24 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 5361.'
  - number: 74
    conditions:
    - condition_type: INTERPRO
      value: IPR034720
      curie: InterPro:IPR034720
      label: Viral alkaline exonuclease
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 24. 24 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 963.'
  - number: 75
    conditions:
    - condition_type: INTERPRO
      value: IPR001098
      curie: InterPro:IPR001098
      label: DNA-directed DNA polymerase, family A, palm domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR002562
      curie: InterPro:IPR002562
      label: 3'-5' exonuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018320
      curie: InterPro:IPR018320
      label: DNA polymerase 1
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 14563.'
  - number: 76
    conditions:
    - condition_type: INTERPRO
      value: IPR001257
      curie: InterPro:IPR001257
      label: Parvovirus non-structural protein 1, helicase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014015
      curie: InterPro:IPR014015
      label: Helicase, superfamily 3, DNA virus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR049901
      curie: InterPro:IPR049901
      label: NS1 nuclease, NS1-Nuc domain, Parvovirus
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 697.'
  - number: 77
    conditions:
    - condition_type: INTERPRO
      value: IPR002738
      curie: InterPro:IPR002738
      label: RNase P subunit p30
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR016195
      curie: InterPro:IPR016195
      label: Polymerase/histidinol phosphatase-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023539
      curie: InterPro:IPR023539
      label: Ribonuclease P, protein component 3, archaeal
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 480.'
  - number: 78
    conditions:
    - condition_type: INTERPRO
      value: IPR008226
      curie: InterPro:IPR008226
      label: Mini-ribonuclease 3 family
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR34276
      curie: PANTHER:PTHR34276
      label: MINI-RIBONUCLEASE 3
      negated: false
    - condition_type: PANTHER
      value: PTHR34276:SF1
      curie: PANTHER:PTHR34276:SF1
      label: MINI-RIBONUCLEASE 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3568.'
  - number: 79
    conditions:
    - condition_type: INTERPRO
      value: IPR006941
      curie: InterPro:IPR006941
      label: Ribonuclease CAF1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR039637
      curie: InterPro:IPR039637
      label: CCR4-NOT transcription complex subunit 7/8/Pop2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 8985.'
  - number: 80
    conditions:
    - condition_type: INTERPRO
      value: IPR040643
      curie: InterPro:IPR040643
      label: Murine leukemia virus integrase, C-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2900.'
  - number: 81
    conditions:
    - condition_type: INTERPRO
      value: IPR002705
      curie: InterPro:IPR002705
      label: Peptidase C30/C16, Betacoronavirus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR022570
      curie: InterPro:IPR022570
      label: NSP1, betacoronavirus lineage A
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR022733
      curie: InterPro:IPR022733
      label: DPUP/SUD, C-terminal, betacoronavirus
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 22. 22 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 150.'
  - number: 82
    conditions:
    - condition_type: INTERPRO
      value: IPR004466
      curie: InterPro:IPR004466
      label: Ribonuclease M5
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR006171
      curie: InterPro:IPR006171
      label: TOPRIM domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR025156
      curie: InterPro:IPR025156
      label: Ribonuclease M5, C-terminal domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 22. 22 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2703.'
  - number: 83
    conditions:
    - condition_type: INTERPRO
      value: IPR003100
      curie: InterPro:IPR003100
      label: PAZ domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR036085
      curie: InterPro:IPR036085
      label: PAZ domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR14950
      curie: PANTHER:PTHR14950
      label: DICER-RELATED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4574.'
  - number: 84
    conditions:
    - condition_type: INTERPRO
      value: IPR004601
      curie: InterPro:IPR004601
      label: UV-endonuclease UvdE
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036237
      curie: InterPro:IPR036237
      label: Xylose isomerase-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR31290:SF5
      curie: PANTHER:PTHR31290:SF5
      label: UV-DAMAGE ENDONUCLEASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3339.'
  - number: 85
    conditions:
    - condition_type: INTERPRO
      value: IPR019190
      curie: InterPro:IPR019190
      label: Exonuclease V
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR14464:SF4
      curie: PANTHER:PTHR14464:SF4
      label: EXONUCLEASE V
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1035.'
  - number: 86
    conditions:
    - condition_type: INTERPRO
      value: IPR021718
      curie: InterPro:IPR021718
      label: Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR022712
      curie: InterPro:IPR022712
      label: Beta-Casp domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050698
      curie: InterPro:IPR050698
      label: RNA Processing Metallo-Beta-Lactamase
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4215.'
  - number: 87
    conditions:
    - condition_type: INTERPRO
      value: IPR011805
      curie: InterPro:IPR011805
      label: Ribonuclease R
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR23355:SF9
      curie: PANTHER:PTHR23355:SF9
      label: DIS3-LIKE EXONUCLEASE 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 12643.'
  - number: 88
    conditions:
    - condition_type: INTERPRO
      value: IPR002121
      curie: InterPro:IPR002121
      label: HRDC domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006292
      curie: InterPro:IPR006292
      label: Ribonuclease D
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR010997
      curie: InterPro:IPR010997
      label: HRDC-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 20. 20 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 5046.'
  - number: 89
    conditions:
    - condition_type: INTERPRO
      value: IPR007159
      curie: InterPro:IPR007159
      label: SpoVT-AbrB domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014944
      curie: InterPro:IPR014944
      label: Toxin SymE-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR020883
      curie: InterPro:IPR020883
      label: Type I toxin-antitoxin system, SymE toxin
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 20. 20 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 50.'
  - number: 90
    conditions:
    - condition_type: INTERPRO
      value: IPR006166
      curie: InterPro:IPR006166
      label: ERCC4 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR033309
      curie: InterPro:IPR033309
      label: Crossover junction endonuclease Mus81
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR042530
      curie: InterPro:IPR042530
      label: EME1/EME2, C-terminal domain
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 19. 19 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3208.'
  - number: 91
    conditions:
    - condition_type: INTERPRO
      value: IPR051132
      curie: InterPro:IPR051132
      label: 3'-5' Exonuclease domain-containing protein
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 19. 19 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 10206.'
  - number: 92
    conditions:
    - condition_type: INTERPRO
      value: IPR038729
      curie: InterPro:IPR038729
      label: Rad50/SbcC-type AAA domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR053380
      curie: InterPro:IPR053380
      label: SbcCD Nuclease Subunit C
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR32114
      curie: PANTHER:PTHR32114
      label: ABC TRANSPORTER ABCH.3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 76.'
  - number: 93
    conditions:
    - condition_type: INTERPRO
      value: IPR033771
      curie: InterPro:IPR033771
      label: Rrp44-like cold shock domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR041505
      curie: InterPro:IPR041505
      label: Dis3-like cold-shock domain 2
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6086.'
  - number: 94
    conditions:
    - condition_type: INTERPRO
      value: IPR041373
      curie: InterPro:IPR041373
      label: Reverse transcriptase, RNase H-like domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 72006.'
  - number: 95
    conditions:
    - condition_type: INTERPRO
      value: IPR003701
      curie: InterPro:IPR003701
      label: DNA double-strand break repair protein Mre11
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR007281
      curie: InterPro:IPR007281
      label: Mre11, DNA-binding
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR10139
      curie: PANTHER:PTHR10139
      label: DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3744.'
  - number: 96
    conditions:
    - condition_type: INTERPRO
      value: IPR033411
      curie: InterPro:IPR033411
      label: Ribonuclease, PIN domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR039907
      curie: InterPro:IPR039907
      label: RNA-binding protein NOB1
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR12814:SF2
      curie: PANTHER:PTHR12814:SF2
      label: RNA-BINDING PROTEIN NOB1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4262.'
  - number: 97
    conditions:
    - condition_type: INTERPRO
      value: IPR008766
      curie: InterPro:IPR008766
      label: Replication gene A protein-like
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1448.'
  - number: 98
    conditions:
    - condition_type: INTERPRO
      value: IPR040476
      curie: InterPro:IPR040476
      label: RNase II/RNase R, cold shock domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 12708.'
  - number: 99
    conditions:
    - condition_type: INTERPRO
      value: IPR047567
      curie: InterPro:IPR047567
      label: Non-structural protein NSP3, group 2-specific marker domain, betacoronavirus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR047573
      curie: InterPro:IPR047573
      label: Non-structural protein 2, middle domain, coronavirus
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR11106
      curie: PANTHER:PTHR11106
      label: GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 210.'
  - number: 100
    conditions:
    - condition_type: INTERPRO
      value: IPR002214
      curie: InterPro:IPR002214
      label: Hantavirus nucleocapsid protein
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Negarnaviricota
      curie: NCBITaxon:2497569
      label: Negarnaviricota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1899.'
  - number: 101
    conditions:
    - condition_type: INTERPRO
      value: IPR018998
      curie: InterPro:IPR018998
      label: EndoU ribonuclease, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR039787
      curie: InterPro:IPR039787
      label: Poly(U)-specific endoribonuclease
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4437.'
  - number: 102
    conditions:
    - condition_type: INTERPRO
      value: IPR008201
      curie: InterPro:IPR008201
      label: Ribonuclease HepT-like
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7931.'
  - number: 103
    conditions:
    - condition_type: INTERPRO
      value: IPR002732
      curie: InterPro:IPR002732
      label: Holliday junction resolvase Hjc
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR014428
      curie: InterPro:IPR014428
      label: Crossover junction endodeoxyribonuclease Hjc, archaeal
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR39651:SF1
      curie: PANTHER:PTHR39651:SF1
      label: HOLLIDAY JUNCTION RESOLVASE HJC
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 580.'
  - number: 104
    conditions:
    - condition_type: INTERPRO
      value: IPR006133
      curie: InterPro:IPR006133
      label: DNA-directed DNA polymerase, family B, exonuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR025687
      curie: InterPro:IPR025687
      label: C4-type zinc-finger of DNA polymerase delta
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050240
      curie: InterPro:IPR050240
      label: DNA polymerase type-B
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3426.'
  - number: 105
    conditions:
    - condition_type: INTERPRO
      value: IPR006310
      curie: InterPro:IPR006310
      label: 3'-5' exonuclease DinG
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR006555
      curie: InterPro:IPR006555
      label: ATP-dependent helicase, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014013
      curie: InterPro:IPR014013
      label: Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1914.'
  - number: 106
    conditions:
    - condition_type: INTERPRO
      value: IPR007409
      curie: InterPro:IPR007409
      label: Restriction endonuclease, type I, HsdR, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051268
      curie: InterPro:IPR051268
      label: Type I restriction enzyme R subunit
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 9250.'
  - number: 107
    conditions:
    - condition_type: INTERPRO
      value: IPR044094
      curie: InterPro:IPR044094
      label: AtsA-like, MBL-fold
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Mycobacteriales
      curie: NCBITaxon:85007
      label: Mycobacteriales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 322.'
  - number: 108
    conditions:
    - condition_type: INTERPRO
      value: IPR014883
      curie: InterPro:IPR014883
      label: VRR-NUC domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7707.'
  - number: 109
    conditions:
    - condition_type: INTERPRO
      value: IPR033114
      curie: InterPro:IPR033114
      label: Cas9-type HNH domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1602.'
  - number: 110
    conditions:
    - condition_type: INTERPRO
      value: IPR004808
      curie: InterPro:IPR004808
      label: AP endonuclease 1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR020847
      curie: InterPro:IPR020847
      label: AP endonuclease 1, binding site
      interpro_type: BINDING_SITE
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 977.'
  - number: 111
    conditions:
    - condition_type: INTERPRO
      value: IPR006309
      curie: InterPro:IPR006309
      label: DNA polymerase 3, epsilon subunit
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR30231:SF41
      curie: PANTHER:PTHR30231:SF41
      label: DNA POLYMERASE III SUBUNIT EPSILON
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6823.'
  - number: 112
    conditions:
    - condition_type: INTERPRO
      value: IPR047151
      curie: InterPro:IPR047151
      label: Zinc phosphodiesterase ELAC protein 2-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 5324.'
  - number: 113
    conditions:
    - condition_type: INTERPRO
      value: IPR001604
      curie: InterPro:IPR001604
      label: DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018524
      curie: InterPro:IPR018524
      label: DNA/RNA non-specific endonuclease, active site
      interpro_type: ACTIVE_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR044929
      curie: InterPro:IPR044929
      label: DNA/RNA non-specific endonuclease superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 5576.'
  - number: 114
    conditions:
    - condition_type: INTERPRO
      value: IPR001650
      curie: InterPro:IPR001650
      label: Helicase, C-terminal domain-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR005034
      curie: InterPro:IPR005034
      label: Dicer, dimerisation domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR048512
      curie: InterPro:IPR048512
      label: Dicer, platform domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2121.'
  - number: 115
    conditions:
    - condition_type: INTERPRO
      value: IPR006134
      curie: InterPro:IPR006134
      label: DNA-directed DNA polymerase, family B, multifunctional domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006172
      curie: InterPro:IPR006172
      label: DNA-directed DNA polymerase, family B
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR061942
      curie: InterPro:IPR061942
      label: Alphaherpesvirus DNA polymerase, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 228.'
  - number: 116
    conditions:
    - condition_type: INTERPRO
      value: IPR013961
      curie: InterPro:IPR013961
      label: RAI1-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR039039
      curie: InterPro:IPR039039
      label: RAI1-like family
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Saccharomycotina
      curie: NCBITaxon:147537
      label: Saccharomycotina
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 268.'
  - number: 117
    conditions:
    - condition_type: INTERPRO
      value: IPR042087
      curie: InterPro:IPR042087
      label: DNA polymerase family B, thumb domain
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR056435
      curie: InterPro:IPR056435
      label: DNA polymerase delta/zeta catalytic subunit, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR10322:SF23
      curie: PANTHER:PTHR10322:SF23
      label: DNA POLYMERASE DELTA CATALYTIC SUBUNIT
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2101.'
  - number: 118
    conditions:
    - condition_type: INTERPRO
      value: IPR013343
      curie: InterPro:IPR013343
      label: CRISPR-associated protein Cas4
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3404.'
  - number: 119
    conditions:
    - condition_type: INTERPRO
      value: IPR001568
      curie: InterPro:IPR001568
      label: Ribonuclease T2-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR018188
      curie: InterPro:IPR018188
      label: Ribonuclease T2, His active site 1
      interpro_type: ACTIVE_SITE
      negated: false
    - condition_type: TAXON
      value: rosids
      curie: NCBITaxon:71275
      label: rosids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1816.'
  - number: 120
    conditions:
    - condition_type: INTERPRO
      value: IPR001736
      curie: InterPro:IPR001736
      label: Phospholipase D/Transphosphatidylase
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR032803
      curie: InterPro:IPR032803
      label: PLD3/4-like, PLD-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR10185:SF16
      curie: PANTHER:PTHR10185:SF16
      label: 5'-3' EXONUCLEASE PLD3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 779.'
  - number: 121
    conditions:
    - condition_type: INTERPRO
      value: IPR001870
      curie: InterPro:IPR001870
      label: B30.2/SPRY domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003877
      curie: InterPro:IPR003877
      label: SPRY domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR011545
      curie: InterPro:IPR011545
      label: DEAD/DEAH-box helicase domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1764.'
  - number: 122
    conditions:
    - condition_type: INTERPRO
      value: IPR002759
      curie: InterPro:IPR002759
      label: RNase P subunit Pop5/Rpp14/Rnp2-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR038085
      curie: InterPro:IPR038085
      label: RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Stenosarchaea group
      curie: NCBITaxon:2290931
      label: Stenosarchaea group
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 363.'
  - number: 123
    conditions:
    - condition_type: INTERPRO
      value: IPR007346
      curie: InterPro:IPR007346
      label: Endonuclease I
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR044925
      curie: InterPro:IPR044925
      label: His-Me finger superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR33607:SF2
      curie: PANTHER:PTHR33607:SF2
      label: ENDONUCLEASE-1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6716.'
  - number: 124
    conditions:
    - condition_type: INTERPRO
      value: IPR008822
      curie: InterPro:IPR008822
      label: Holliday junction resolvase RusA-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR016281
      curie: InterPro:IPR016281
      label: Crossover junction endodeoxyribonuclease, RusA
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036614
      curie: InterPro:IPR036614
      label: Holliday junction resolvase RusA-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 433.'
  - number: 125
    conditions:
    - condition_type: INTERPRO
      value: IPR010994
      curie: InterPro:IPR010994
      label: RuvA domain 2-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR10150
      curie: PANTHER:PTHR10150
      label: DNA REPAIR ENDONUCLEASE XPF
      negated: false
    - condition_type: PANTHER
      value: PTHR10150:SF0
      curie: PANTHER:PTHR10150:SF0
      label: DNA REPAIR ENDONUCLEASE XPF
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3781.'
  - number: 126
    conditions:
    - condition_type: INTERPRO
      value: IPR027521
      curie: InterPro:IPR027521
      label: U6 snRNA phosphodiesterase 1
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR13522:SF3
      curie: PANTHER:PTHR13522:SF3
      label: U6 SNRNA PHOSPHODIESTERASE 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3684.'
  - number: 127
    conditions:
    - condition_type: INTERPRO
      value: IPR000883
      curie: InterPro:IPR000883
      label: Cytochrome c oxidase subunit I
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR004860
      curie: InterPro:IPR004860
      label: Homing endonuclease, LAGLIDADG domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR023616
      curie: InterPro:IPR023616
      label: Cytochrome c oxidase-like, subunit I domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 91.'
  - number: 128
    conditions:
    - condition_type: INTERPRO
      value: IPR004659
      curie: InterPro:IPR004659
      label: Ribonuclease E/G
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR019307
      curie: InterPro:IPR019307
      label: RNA-binding protein AU-1/Ribonuclease E/G
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR048583
      curie: InterPro:IPR048583
      label: RNase E/G, thioredoxin-like domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 10825.'
  - number: 129
    conditions:
    - condition_type: INTERPRO
      value: IPR014808
      curie: InterPro:IPR014808
      label: DNA replication factor Dna2, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR041677
      curie: InterPro:IPR041677
      label: DNA2/NAM7 helicase, helicase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR047187
      curie: InterPro:IPR047187
      label: Upf1-like, C-terminal helicase domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3215.'
  - number: 130
    conditions:
    - condition_type: INTERPRO
      value: IPR021590
      curie: InterPro:IPR021590
      label: NSP1, globular domain, betacoronavirus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR024358
      curie: InterPro:IPR024358
      label: Non-structural protein NSP3, N-terminal, betacoronavirus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR024375
      curie: InterPro:IPR024375
      label: Non-structural protein NSP3, SUD-M domain, betacoronavirus
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 297.'
  - number: 131
    conditions:
    - condition_type: INTERPRO
      value: IPR021869
      curie: InterPro:IPR021869
      label: Ribonuclease Zc3h12a-like, NYN domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR040546
      curie: InterPro:IPR040546
      label: Rege-1, UBA-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051101
      curie: InterPro:IPR051101
      label: ZC3H12/N4BP1 Ribonuclease and Regulator
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3809.'
  - number: 132
    conditions:
    - condition_type: INTERPRO
      value: IPR033697
      curie: InterPro:IPR033697
      label: Ribonuclease T2, eukaryotic
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036430
      curie: InterPro:IPR036430
      label: Ribonuclease T2-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: lamiids
      curie: NCBITaxon:91888
      label: lamiids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 409.'
  - number: 133
    conditions:
    - condition_type: PANTHER
      value: PTHR15441
      curie: PANTHER:PTHR15441
      label: RIBONUCLEASE P PROTEIN SUBUNIT P14
      negated: false
    - condition_type: PANTHER
      value: PTHR15441:SF2
      curie: PANTHER:PTHR15441:SF2
      label: RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5
      negated: false
    - condition_type: TAXON
      value: Methanomada group
      curie: NCBITaxon:2283794
      label: Methanomada group
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 57.'
  - number: 134
    conditions:
    - condition_type: INTERPRO
      value: IPR021972
      curie: InterPro:IPR021972
      label: Parvovirus non-structural protein 1, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Quintoviricetes
      curie: NCBITaxon:2732422
      label: Quintoviricetes
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 186.'
  - number: 135
    conditions:
    - condition_type: INTERPRO
      value: IPR006853
      curie: InterPro:IPR006853
      label: Poxin, virus
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 186.'
  - number: 136
    conditions:
    - condition_type: INTERPRO
      value: IPR003586
      curie: InterPro:IPR003586
      label: Hint domain C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003587
      curie: InterPro:IPR003587
      label: Hint domain N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Mycobacterium tuberculosis complex
      curie: NCBITaxon:77643
      label: Mycobacterium tuberculosis complex
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 21.'
  - number: 137
    conditions:
    - condition_type: INTERPRO
      value: IPR007099
      curie: InterPro:IPR007099
      label: RNA-directed RNA polymerase, negative-strand RNA virus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR007322
      curie: InterPro:IPR007322
      label: RNA-dependent RNA polymerase, bunyaviral
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR016268
      curie: InterPro:IPR016268
      label: RNA-directed RNA polymerase, hantavirus
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 159.'
  - number: 138
    conditions:
    - condition_type: INTERPRO
      value: IPR011149
      curie: InterPro:IPR011149
      label: DNA polymerase II small subunit, archaeal
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR024826
      curie: InterPro:IPR024826
      label: DNA polymerase delta/II small subunit family
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR10416:SF0
      curie: PANTHER:PTHR10416:SF0
      label: DNA POLYMERASE DELTA SUBUNIT 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 531.'
  - number: 139
    conditions:
    - condition_type: INTERPRO
      value: IPR015946
      curie: InterPro:IPR015946
      label: K homology domain-like, alpha/beta
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR019975
      curie: InterPro:IPR019975
      label: Transcription termination factor CPSF1, archaea
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR033769
      curie: InterPro:IPR033769
      label: Transcription termination factor FttA, KH domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 656.'
  - number: 140
    conditions:
    - condition_type: INTERPRO
      value: IPR024627
      curie: InterPro:IPR024627
      label: V(D)J recombination-activating protein 1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR058556
      curie: InterPro:IPR058556
      label: V(D)J recombination-activating protein 1, ZnH2 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR058557
      curie: InterPro:IPR058557
      label: V(D)J recombination-activating protein 1, C-terminal domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 2161.'
  - number: 141
    conditions:
    - condition_type: INTERPRO
      value: IPR033130
      curie: InterPro:IPR033130
      label: Ribonuclease T2, His active site 2
      interpro_type: ACTIVE_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR057328
      curie: InterPro:IPR057328
      label: RNase T2-like, C-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR11240:SF22
      curie: PANTHER:PTHR11240:SF22
      label: RIBONUCLEASE T2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 740.'
  - number: 142
    conditions:
    - condition_type: INTERPRO
      value: IPR000916
      curie: InterPro:IPR000916
      label: Bet v I/Major latex protein
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR023393
      curie: InterPro:IPR023393
      label: START-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: genistoids sensu lato
      curie: NCBITaxon:2231384
      label: genistoids sensu lato
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 153.'
  - number: 143
    conditions:
    - condition_type: INTERPRO
      value: IPR001667
      curie: InterPro:IPR001667
      label: DHH domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003156
      curie: InterPro:IPR003156
      label: DHHA1 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051673
      curie: InterPro:IPR051673
      label: Single-stranded-DNA-specific exonuclease RecJ
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 14515.'
  - number: 144
    conditions:
    - condition_type: INTERPRO
      value: IPR002711
      curie: InterPro:IPR002711
      label: HNH endonuclease
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR41286
      curie: PANTHER:PTHR41286
      label: HNH NUCLEASE YAJD-RELATED
      negated: false
    - condition_type: PANTHER
      value: PTHR41286:SF1
      curie: PANTHER:PTHR41286:SF1
      label: HNH NUCLEASE YAJD-RELATED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 5425.'
  - number: 145
    conditions:
    - condition_type: INTERPRO
      value: IPR006344
      curie: InterPro:IPR006344
      label: RecBCD enzyme subunit RecD
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR027785
      curie: InterPro:IPR027785
      label: UvrD-like helicase C-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR041851
      curie: InterPro:IPR041851
      label: RecBCD enzyme subunit RecD, N-terminal domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 3975.'
  - number: 146
    conditions:
    - condition_type: INTERPRO
      value: IPR009060
      curie: InterPro:IPR009060
      label: UBA-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR051547
      curie: InterPro:IPR051547
      label: Tyrosyl-DNA phosphodiesterase 2-like
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR15822:SF4
      curie: PANTHER:PTHR15822:SF4
      label: TYROSYL-DNA PHOSPHODIESTERASE 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 901.'
  - number: 147
    conditions:
    - condition_type: INTERPRO
      value: IPR009614
      curie: InterPro:IPR009614
      label: Toxin YoeB
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR035093
      curie: InterPro:IPR035093
      label: Toxin-antitoxin system, RelE/ParE toxin domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR38039:SF1
      curie: PANTHER:PTHR38039:SF1
      label: TOXIN YOEB
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 5725.'
  - number: 148
    conditions:
    - condition_type: INTERPRO
      value: IPR011990
      curie: InterPro:IPR011990
      label: Tetratricopeptide-like helical domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR031595
      curie: InterPro:IPR031595
      label: Protein-only RNase P-like, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR13547
      curie: PANTHER:PTHR13547
      label: FAMILY NOT NAMED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 2942.'
  - number: 149
    conditions:
    - condition_type: INTERPRO
      value: IPR038763
      curie: InterPro:IPR038763
      label: DHH phosphoesterase superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR041122
      curie: InterPro:IPR041122
      label: RecJ, OB domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR30255:SF2
      curie: PANTHER:PTHR30255:SF2
      label: SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 13991.'
  - number: 150
    conditions:
    - condition_type: INTERPRO
      value: IPR045092
      curie: InterPro:IPR045092
      label: Exosome complex exonuclease Rrp6-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR049559
      curie: InterPro:IPR049559
      label: Rrp6-like, 3'-5' exonuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR12124:SF47
      curie: PANTHER:PTHR12124:SF47
      label: EXOSOME COMPONENT 10
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 3949.'
  - number: 151
    conditions:
    - condition_type: INTERPRO
      value: IPR003154
      curie: InterPro:IPR003154
      label: S1/P1 nuclease
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR008947
      curie: InterPro:IPR008947
      label: Phospholipase C/P1 nuclease domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 8416.'
  - number: 152
    conditions:
    - condition_type: INTERPRO
      value: IPR010347
      curie: InterPro:IPR010347
      label: Tyrosyl-DNA phosphodiesterase I
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR12415:SF0
      curie: PANTHER:PTHR12415:SF0
      label: TYROSYL-DNA PHOSPHODIESTERASE 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 4518.'
  - number: 153
    conditions:
    - condition_type: INTERPRO
      value: IPR027806
      curie: InterPro:IPR027806
      label: Harbinger transposase-derived nuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR045249
      curie: InterPro:IPR045249
      label: Putative nuclease HARBI1-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 37806.'
  - number: 154
    conditions:
    - condition_type: INTERPRO
      value: IPR044382
      curie: InterPro:IPR044382
      label: NSP3, SUD-C domain, MERS-CoV-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Merbecovirus
      curie: NCBITaxon:2509494
      label: Merbecovirus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 238.'
  - number: 155
    conditions:
    - condition_type: PANTHER
      value: PTHR11240:SF75
      curie: PANTHER:PTHR11240:SF75
      label: RIBONUCLEASE 3
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 1314.'
  - number: 156
    conditions:
    - condition_type: PANTHER
      value: PTHR38826
      curie: PANTHER:PTHR38826
      label: RIBONUCLEASE VAPC13
      negated: false
    - condition_type: PANTHER
      value: PTHR38826:SF5
      curie: PANTHER:PTHR38826:SF5
      label: RIBONUCLEASE VAPC13
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 1584.'
  - number: 157
    conditions:
    - condition_type: INTERPRO
      value: IPR016368
      curie: InterPro:IPR016368
      label: Endoribonuclease VapD
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 157.'
  - number: 158
    conditions:
    - condition_type: PANTHER
      value: PTHR11437:SF53
      curie: PANTHER:PTHR11437:SF53
      label: RIBONUCLEASE 4
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 231.'
  - number: 159
    conditions:
    - condition_type: INTERPRO
      value: IPR003165
      curie: InterPro:IPR003165
      label: Piwi domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014811
      curie: InterPro:IPR014811
      label: Argonaute, linker 1 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR028602
      curie: InterPro:IPR028602
      label: Protein argonaute-2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 1056.'
  - number: 160
    conditions:
    - condition_type: INTERPRO
      value: IPR003593
      curie: InterPro:IPR003593
      label: AAA+ ATPase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR004042
      curie: InterPro:IPR004042
      label: Intein DOD homing endonuclease, central region
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006142
      curie: InterPro:IPR006142
      label: Intein
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 177.'
  - number: 161
    conditions:
    - condition_type: INTERPRO
      value: IPR019518
      curie: InterPro:IPR019518
      label: DNA endonuclease Ctp1, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR033316
      curie: InterPro:IPR033316
      label: DNA endonuclease RBBP8-like
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR15107:SF4
      curie: PANTHER:PTHR15107:SF4
      label: DNA ENDONUCLEASE RBBP8
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 852.'
  - number: 162
    conditions:
    - condition_type: INTERPRO
      value: IPR036890
      curie: InterPro:IPR036890
      label: Histidine kinase/HSP90-like ATPase superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR041006
      curie: InterPro:IPR041006
      label: Morc, S5 domain 2-like
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Streptophyta
      curie: NCBITaxon:35493
      label: Streptophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 3107.'
  - number: 163
    conditions:
    - condition_type: INTERPRO
      value: IPR041175
      curie: InterPro:IPR041175
      label: VLRF1/Vms1
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR047139
      curie: InterPro:IPR047139
      label: tRNA endonuclease ANKZF1/VMS1
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR16036:SF2
      curie: PANTHER:PTHR16036:SF2
      label: TRNA ENDONUCLEASE ANKZF1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 3666.'
  - number: 164
    conditions:
    - condition_type: INTERPRO
      value: IPR006932
      curie: InterPro:IPR006932
      label: Holliday junction resolvase, A22
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Varidnaviria
      curie: NCBITaxon:2732004
      label: Varidnaviria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 72.'
  - number: 165
    conditions:
    - condition_type: INTERPRO
      value: IPR033310
      curie: InterPro:IPR033310
      label: Mms4/EME1/EME2
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR21077:SF5
      curie: PANTHER:PTHR21077:SF5
      label: CROSSOVER JUNCTION ENDONUCLEASE MMS4
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 2535.'
  - number: 166
    conditions:
    - condition_type: INTERPRO
      value: IPR053395
      curie: InterPro:IPR053395
      label: CRISPR-associated endoribonuclease Cas13a
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR060667
      curie: InterPro:IPR060667
      label: CRISPR-associated endoribonuclease Cas13a, N-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 39.'
  - number: 167
    conditions:
    - condition_type: PANTHER
      value: PTHR30001:SF1
      curie: PANTHER:PTHR30001:SF1
      label: RIBONUCLEASE E_G-LIKE PROTEIN, CHLOROPLASTIC
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 9123.'
  - number: 168
    conditions:
    - condition_type: INTERPRO
      value: IPR000160
      curie: InterPro:IPR000160
      label: GGDEF domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR013408
      curie: InterPro:IPR013408
      label: CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR041062
      curie: InterPro:IPR041062
      label: Csm1, subunit domain B
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 512.'
  - number: 169
    conditions:
    - condition_type: INTERPRO
      value: IPR001374
      curie: InterPro:IPR001374
      label: R3H domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR012677
      curie: InterPro:IPR012677
      label: Nucleotide-binding alpha-beta plait domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR014789
      curie: InterPro:IPR014789
      label: Poly(A)-specific ribonuclease, RNA-binding
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 1092.'
  - number: 170
    conditions:
    - condition_type: INTERPRO
      value: IPR003729
      curie: InterPro:IPR003729
      label: Bifunctional nuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR036104
      curie: InterPro:IPR036104
      label: Bifunctional nuclease superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Spermatophyta
      curie: NCBITaxon:58024
      label: Spermatophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 1407.'
  - number: 171
    conditions:
    - condition_type: INTERPRO
      value: IPR004868
      curie: InterPro:IPR004868
      label: DNA-directed DNA polymerase, family B, mitochondria/virus
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014416
      curie: InterPro:IPR014416
      label: DNA-directed DNA polymerase, family B, phi29-like virus
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR33568
      curie: PANTHER:PTHR33568
      label: DNA POLYMERASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 15.'
  - number: 172
    conditions:
    - condition_type: INTERPRO
      value: IPR005537
      curie: InterPro:IPR005537
      label: CRISPR type III-associated protein
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR013412
      curie: InterPro:IPR013412
      label: CRISPR-associated RAMP Csm3
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR35579
      curie: PANTHER:PTHR35579
      label: CRISPR SYSTEM CMS ENDORIBONUCLEASE CSM3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 572.'
  - number: 173
    conditions:
    - condition_type: INTERPRO
      value: IPR006474
      curie: InterPro:IPR006474
      label: Helicase Cas3, CRISPR-associated, core
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006483
      curie: InterPro:IPR006483
      label: CRISPR-associated Cas3-type, HD domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR038257
      curie: InterPro:IPR038257
      label: CRISPR-associated Cas3-type HD domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 4410.'
  - number: 174
    conditions:
    - condition_type: INTERPRO
      value: IPR008741
      curie: InterPro:IPR008741
      label: Arterivirus papain-like cysteine protease alpha (PCPalpha) domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR008760
      curie: InterPro:IPR008760
      label: Equine arteritis virus-type peptidase S32
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR032855
      curie: InterPro:IPR032855
      label: Arterivirus polyprotein, nsp2, immunogenic region
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 253.'
  - number: 175
    conditions:
    - condition_type: INTERPRO
      value: IPR011084
      curie: InterPro:IPR011084
      label: DNA repair metallo-beta-lactamase
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR23240
      curie: PANTHER:PTHR23240
      label: DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED
      negated: false
    - condition_type: PANTHER
      value: PTHR23240:SF26
      curie: PANTHER:PTHR23240:SF26
      label: 5' EXONUCLEASE APOLLO
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 865.'
  - number: 176
    conditions:
    - condition_type: INTERPRO
      value: IPR012310
      curie: InterPro:IPR012310
      label: DNA ligase, ATP-dependent, central
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014145
      curie: InterPro:IPR014145
      label: DNA ligase D, polymerase domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR014146
      curie: InterPro:IPR014146
      label: DNA ligase D, ligase domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 5436.'
  - number: 177
    conditions:
    - condition_type: INTERPRO
      value: IPR016128
      curie: InterPro:IPR016128
      label: Pyosin/cloacin translocation domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR024566
      curie: InterPro:IPR024566
      label: Colicin, receptor domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR024575
      curie: InterPro:IPR024575
      label: Cloacin/colicin
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 20.'
  - number: 178
    conditions:
    - condition_type: INTERPRO
      value: IPR056578
      curie: InterPro:IPR056578
      label: N4BP1, C-terminal UBA domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR056629
      curie: InterPro:IPR056629
      label: N4BP1, first type I KH-domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR12876:SF26
      curie: PANTHER:PTHR12876:SF26
      label: NEDD4-BINDING PROTEIN 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 622.'
  - number: 179
    conditions:
    - condition_type: INTERPRO
      value: IPR022688
      curie: InterPro:IPR022688
      label: Replication-associated protein G2P, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Loebvirae
      curie: NCBITaxon:2732090
      label: Loebvirae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 29.'
  - number: 180
    conditions:
    - condition_type: INTERPRO
      value: IPR004603
      curie: InterPro:IPR004603
      label: DNA mismatch endonuclease VSR
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 5517.'
  - number: 181
    conditions:
    - condition_type: INTERPRO
      value: IPR037146
      curie: InterPro:IPR037146
      label: Colicin/pyocin, DNase domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 482.'
  - number: 182
    conditions:
    - condition_type: INTERPRO
      value: IPR040393
      curie: InterPro:IPR040393
      label: Three-prime repair exonuclease 1/2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 3504.'
  - number: 183
    conditions:
    - condition_type: PANTHER
      value: PTHR23240:SF8
      curie: PANTHER:PTHR23240:SF8
      label: PROTEIN ARTEMIS
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 3684.'
  - number: 184
    conditions:
    - condition_type: INTERPRO
      value: IPR000280
      curie: InterPro:IPR000280
      label: Pestivirus NS3, peptidase S31
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR002166
      curie: InterPro:IPR002166
      label: RNA dependent RNA polymerase, hepatitis C virus
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR008751
      curie: InterPro:IPR008751
      label: Peptidase C53, pestivirus Npro
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 312.'
  - number: 185
    conditions:
    - condition_type: INTERPRO
      value: IPR000795
      curie: InterPro:IPR000795
      label: Translational (tr)-type GTP-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR004161
      curie: InterPro:IPR004161
      label: Translation elongation factor EFTu-like, domain 2
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006141
      curie: InterPro:IPR006141
      label: Intein N-terminal splicing region
      interpro_type: PTM
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 15.'
  - number: 186
    conditions:
    - condition_type: INTERPRO
      value: IPR001233
      curie: InterPro:IPR001233
      label: RNA-splicing ligase, RtcB
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR030934
      curie: InterPro:IPR030934
      label: Intein C-terminal splicing region
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR036025
      curie: InterPro:IPR036025
      label: tRNA-splicing ligase RtcB-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 112.'
  - number: 187
    conditions:
    - condition_type: INTERPRO
      value: IPR002792
      curie: InterPro:IPR002792
      label: TRAM domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR052041
      curie: InterPro:IPR052041
      label: Nucleic acid metabolism PIN/TRAM-domain-containing protein
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR060543
      curie: InterPro:IPR060543
      label: YacL/YCF81-like, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 2553.'
  - number: 188
    conditions:
    - condition_type: INTERPRO
      value: IPR003034
      curie: InterPro:IPR003034
      label: SAP domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR047201
      curie: InterPro:IPR047201
      label: ERI-1-like, DEDDh 3'-5' exonuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051274
      curie: InterPro:IPR051274
      label: 3'-5' Exoribonuclease
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 856.'
  - number: 189
    conditions:
    - condition_type: INTERPRO
      value: IPR005229
      curie: InterPro:IPR005229
      label: Endoribonuclease YicC/YloC-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR013527
      curie: InterPro:IPR013527
      label: Endoribonuclease YicC-like, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR013551
      curie: InterPro:IPR013551
      label: Endoribonuclease YicC-like, C-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 10686.'
  - number: 190
    conditions:
    - condition_type: INTERPRO
      value: IPR028603
      curie: InterPro:IPR028603
      label: Protein argonaute-3
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR032472
      curie: InterPro:IPR032472
      label: Argonaute linker 2 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR032473
      curie: InterPro:IPR032473
      label: Protein argonaute, Mid domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 703.'
  - number: 191
    conditions:
    - condition_type: INTERPRO
      value: IPR036844
      curie: InterPro:IPR036844
      label: Hint domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR041005
      curie: InterPro:IPR041005
      label: DNA polymerase II intein domain IV
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Thermococcus
      curie: NCBITaxon:2263
      label: Thermococcus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 21.'
  - number: 192
    conditions:
    - condition_type: INTERPRO
      value: IPR037432
      curie: InterPro:IPR037432
      label: Exonuclease Mut-7, DEDDy 3'-5' exonuclease domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR052408
      curie: InterPro:IPR052408
      label: Exonuclease MUT-7-like
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR47765:SF2
      curie: PANTHER:PTHR47765:SF2
      label: EXONUCLEASE MUT-7 HOMOLOG
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 1075.'
  - number: 193
    conditions:
    - condition_type: INTERPRO
      value: IPR003611
      curie: InterPro:IPR003611
      label: Nuclease associated modular domain 3
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003647
      curie: InterPro:IPR003647
      label: Intron encoded nuclease repeat
      interpro_type: REPEAT
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 246.'
  - number: 194
    conditions:
    - condition_type: INTERPRO
      value: IPR004947
      curie: InterPro:IPR004947
      label: Deoxyribonuclease II
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR10858:SF9
      curie: PANTHER:PTHR10858:SF9
      label: DEOXYRIBONUCLEASE-2-ALPHA
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 738.'
  - number: 195
    conditions:
    - condition_type: INTERPRO
      value: IPR007678
      curie: InterPro:IPR007678
      label: Poxvirus G5
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Orthopoxvirus
      curie: NCBITaxon:10242
      label: Orthopoxvirus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 17.'
  - number: 196
    conditions:
    - condition_type: INTERPRO
      value: IPR010156
      curie: InterPro:IPR010156
      label: CRISPR-associated endoribonuclease Cas6
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR019267
      curie: InterPro:IPR019267
      label: CRISPR-associated protein Cas6, C-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 470.'
  - number: 197
    conditions:
    - condition_type: INTERPRO
      value: IPR012933
      curie: InterPro:IPR012933
      label: HicA mRNA interferase family
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR038570
      curie: InterPro:IPR038570
      label: HicA superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 6812.'
  - number: 198
    conditions:
    - condition_type: INTERPRO
      value: IPR040255
      curie: InterPro:IPR040255
      label: Non-specific endonuclease
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 2262.'
  - number: 199
    conditions:
    - condition_type: INTERPRO
      value: IPR019045
      curie: InterPro:IPR019045
      label: Restriction endonuclease, type II, HinfI-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 261.'
  - number: 200
    conditions:
    - condition_type: PANTHER
      value: PTHR30231:SF4
      curie: PANTHER:PTHR30231:SF4
      label: PROTEIN NEN2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry keyword KW-0540 Nuclease. UniProtKB entries
      matching: 13094.'
  - number: 201
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000002
      curie: CATH.FunFam:3.30.420.10:FF:000002
      label: Crossover junction endodeoxyribonuclease RuvC
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 545 (first 500 inspected). 500 carry keyword KW-0540
      Nuclease. UniProtKB entries matching: 15398.'
  - number: 202
    conditions:
    - condition_type: FUNFAM
      value: 1.10.1520.10:FF:000001
      curie: CATH.FunFam:1.10.1520.10:FF:000001
      label: Ribonuclease 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 450. 450 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 15756.'
  - number: 203
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000006
      curie: CATH.FunFam:3.30.420.10:FF:000006
      label: Ribonuclease HII
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 382. 382 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 7446.'
  - number: 204
    conditions:
    - condition_type: FUNFAM
      value: 3.30.160.20:FF:000003
      curie: CATH.FunFam:3.30.160.20:FF:000003
      label: Ribonuclease 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 352. 352 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 10743.'
  - number: 205
    conditions:
    - condition_type: FUNFAM
      value: 3.60.15.10:FF:000002
      curie: CATH.FunFam:3.60.15.10:FF:000002
      label: Ribonuclease Z
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 198. 198 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3006.'
  - number: 206
    conditions:
    - condition_type: FUNFAM
      value: 3.10.130.10:FF:000001
      curie: CATH.FunFam:3.10.130.10:FF:000001
      label: Ribonuclease pancreatic
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 173. 173 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1474.'
  - number: 207
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000089
      curie: CATH.FunFam:3.30.420.10:FF:000089
      label: Ribonuclease H
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 166. 166 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6557.'
  - number: 208
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000003
      curie: CATH.FunFam:3.30.420.10:FF:000003
      label: Oligoribonuclease
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 165. 165 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 10771.'
  - number: 209
    conditions:
    - condition_type: FUNFAM
      value: 3.20.20.150:FF:000001
      curie: CATH.FunFam:3.20.20.150:FF:000001
      label: Probable endonuclease 4
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 136. 136 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1788.'
  - number: 210
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.20:FF:000009
      curie: CATH.FunFam:1.10.150.20:FF:000009
      label: Flap endonuclease 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 132. 132 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4269.'
  - number: 211
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000008
      curie: CATH.FunFam:3.30.420.10:FF:000008
      label: Ribonuclease H
      negated: false
    - condition_type: TAXON
      value: Pseudomonadota
      curie: NCBITaxon:1224
      label: Pseudomonadota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 130. 130 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1962.'
  - number: 212
    conditions:
    - condition_type: FUNFAM
      value: 3.30.230.10:FF:000021
      curie: CATH.FunFam:3.30.230.10:FF:000021
      label: Ribonuclease P protein component
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 112. 112 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1987.'
  - number: 213
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.140:FF:000002
      curie: CATH.FunFam:3.30.420.140:FF:000002
      label: Putative pre-16S rRNA nuclease
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 105. 105 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1487.'
  - number: 214
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3210.10:FF:000003
      curie: CATH.FunFam:1.10.3210.10:FF:000003
      label: Ribonuclease Y
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 102. 102 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2708.'
  - number: 215
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1010:FF:000003
      curie: CATH.FunFam:3.40.50.1010:FF:000003
      label: Flap endonuclease 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 91. 91 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2791.'
  - number: 216
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.140:FF:000003
      curie: CATH.FunFam:3.30.420.140:FF:000003
      label: Putative pre-16S rRNA nuclease
      negated: false
    - condition_type: TAXON
      value: Bacillota
      curie: NCBITaxon:1239
      label: Bacillota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 90. 90 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1037.'
  - number: 217
    conditions:
    - condition_type: FUNFAM
      value: 3.30.1370.10:FF:000006
      curie: CATH.FunFam:3.30.1370.10:FF:000006
      label: Ribonuclease Y
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 86. 86 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3014.'
  - number: 218
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000047
      curie: CATH.FunFam:3.30.420.10:FF:000047
      label: Ribonuclease HIII
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 80. 80 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1217.'
  - number: 219
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1010:FF:000016
      curie: CATH.FunFam:3.40.50.1010:FF:000016
      label: Flap endonuclease 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 79. 79 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1054.'
  - number: 220
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000009
      curie: CATH.FunFam:3.30.420.10:FF:000009
      label: Ribonuclease T
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 78. 78 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2401.'
  - number: 221
    conditions:
    - condition_type: FUNFAM
      value: 3.30.230.10:FF:000016
      curie: CATH.FunFam:3.30.230.10:FF:000016
      label: Ribonuclease P protein component
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 76. 76 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 663.'
  - number: 222
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000045
      curie: CATH.FunFam:3.30.420.10:FF:000045
      label: 3'-5' exonuclease DinG
      negated: false
    - condition_type: TAXON
      value: Bacilli
      curie: NCBITaxon:91061
      label: Bacilli
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 70. 70 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6055.'
  - number: 223
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1040:FF:000001
      curie: CATH.FunFam:1.10.287.1040:FF:000001
      label: Exodeoxyribonuclease 7 small subunit
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 68. 68 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 539.'
  - number: 224
    conditions:
    - condition_type: FUNFAM
      value: 2.40.50.140:FF:000079
      curie: CATH.FunFam:2.40.50.140:FF:000079
      label: Exoribonuclease 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 67. 67 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 588.'
  - number: 225
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:001236
      curie: CATH.FunFam:3.40.50.300:FF:001236
      label: ATP-dependent helicase/nuclease subunit A
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 67. 67 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1680.'
  - number: 226
    conditions:
    - condition_type: FUNFAM
      value: 3.30.2170.10:FF:000001
      curie: CATH.FunFam:3.30.2170.10:FF:000001
      label: Endonuclease V
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 66. 66 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 610.'
  - number: 227
    conditions:
    - condition_type: FUNFAM
      value: 3.40.600.10:FF:000001
      curie: CATH.FunFam:3.40.600.10:FF:000001
      label: DNA mismatch repair protein MutH
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 63. 63 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 537.'
  - number: 228
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.20:FF:000003
      curie: CATH.FunFam:1.10.150.20:FF:000003
      label: DNA polymerase I
      negated: false
    - condition_type: TAXON
      value: Enterobacterales
      curie: NCBITaxon:91347
      label: Enterobacterales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 62. 62 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1083.'
  - number: 229
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1010:FF:000011
      curie: CATH.FunFam:3.40.50.1010:FF:000011
      label: Flap endonuclease Xni
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 58. 58 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 506.'
  - number: 230
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:001196
      curie: CATH.FunFam:3.40.50.300:FF:001196
      label: ATP-dependent helicase/nuclease subunit A
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 57. 57 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 460.'
  - number: 231
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.270:FF:000009
      curie: CATH.FunFam:3.30.70.270:FF:000009
      label: Protein P
      negated: false
    - condition_type: TAXON
      value: Viruses
      curie: NCBITaxon:10239
      label: Viruses
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 51. 51 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2207.'
  - number: 232
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000830
      curie: CATH.FunFam:3.40.50.300:FF:000830
      label: Endonuclease MutS2
      negated: false
    - condition_type: TAXON
      value: Lactobacillales
      curie: NCBITaxon:186826
      label: Lactobacillales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 47. 47 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 755.'
  - number: 233
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000050
      curie: CATH.FunFam:3.30.420.10:FF:000050
      label: Transposon Ty2-DR3 Gag-Pol polyprotein
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 45. 45 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 59.'
  - number: 234
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.420:FF:000001
      curie: CATH.FunFam:1.10.150.420:FF:000001
      label: Replicase polyprotein
      negated: false
    - condition_type: TAXON
      value: Riboviria
      curie: NCBITaxon:2559587
      label: Riboviria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 40. 40 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 690.'
  - number: 235
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.460:FF:000001
      curie: CATH.FunFam:1.10.10.460:FF:000001
      label: Ribonuclease
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 38. 38 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3747.'
  - number: 236
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000017
      curie: CATH.FunFam:3.30.420.10:FF:000017
      label: POL polyprotein
      negated: false
    - condition_type: TAXON
      value: Pararnavirae
      curie: NCBITaxon:2732397
      label: Pararnavirae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 36. 36 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3046.'
  - number: 237
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3210.10:FF:000022
      curie: CATH.FunFam:1.10.3210.10:FF:000022
      label: Ribonuclease Y
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 36. 36 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 673.'
  - number: 238
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3210.10:FF:000008
      curie: CATH.FunFam:1.10.3210.10:FF:000008
      label: 3'-5' exoribonuclease YhaM
      negated: false
    - condition_type: TAXON
      value: Caryophanales
      curie: NCBITaxon:1385
      label: Caryophanales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 833.'
  - number: 239
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.870:FF:000002
      curie: CATH.FunFam:2.30.30.870:FF:000002
      label: Protein pelota homolog
      negated: false
    - condition_type: TAXON
      value: Archaea
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 372.'
  - number: 240
    conditions:
    - condition_type: FUNFAM
      value: 3.40.390.30:FF:000001
      curie: CATH.FunFam:3.40.390.30:FF:000001
      label: Endoribonuclease YbeY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 30. 30 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 109.'
  - number: 241
    conditions:
    - condition_type: FUNFAM
      value: 2.40.50.90:FF:000029
      curie: CATH.FunFam:2.40.50.90:FF:000029
      label: Probable endonuclease lcl3
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 29. 29 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 874.'
  - number: 242
    conditions:
    - condition_type: FUNFAM
      value: 3.10.20.580:FF:000001
      curie: CATH.FunFam:3.10.20.580:FF:000001
      label: Ribonuclease J
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 29. 29 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4135.'
  - number: 243
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000113
      curie: CATH.FunFam:3.30.420.10:FF:000113
      label: Ribonuclease HII
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 29. 29 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 702.'
  - number: 244
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000007
      curie: CATH.FunFam:3.30.420.10:FF:000007
      label: Interferon-stimulated exonuclease gene 20
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 28. 28 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4999.'
  - number: 245
    conditions:
    - condition_type: FUNFAM
      value: 3.20.20.140:FF:000018
      curie: CATH.FunFam:3.20.20.140:FF:000018
      label: 3'-5' ssDNA/RNA exonuclease TatD
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 26. 26 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2097.'
  - number: 246
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.140:FF:000005
      curie: CATH.FunFam:3.30.420.140:FF:000005
      label: Putative pre-16S rRNA nuclease
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 26. 26 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1172.'
  - number: 247
    conditions:
    - condition_type: FUNFAM
      value: 1.25.40.1050:FF:000002
      curie: CATH.FunFam:1.25.40.1050:FF:000002
      label: 5'-3' exoribonuclease
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 25. 25 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 5482.'
  - number: 248
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000028
      curie: CATH.FunFam:3.30.420.10:FF:000028
      label: PAN2-PAN3 deadenylation complex catalytic subunit PAN2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 25. 25 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1408.'
  - number: 249
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.12390:FF:000003
      curie: CATH.FunFam:3.40.50.12390:FF:000003
      label: 5'-3' exoribonuclease
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 25. 25 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4747.'
  - number: 250
    conditions:
    - condition_type: FUNFAM
      value: 3.40.1440.10:FF:000006
      curie: CATH.FunFam:3.40.1440.10:FF:000006
      label: Structure-specific endonuclease subunit SLX1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 24. 24 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 636.'
  - number: 251
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1010:FF:000001
      curie: CATH.FunFam:3.40.50.1010:FF:000001
      label: DNA polymerase I
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 24. 24 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 12459.'
  - number: 252
    conditions:
    - condition_type: FUNFAM
      value: 2.40.50.90:FF:000035
      curie: CATH.FunFam:2.40.50.90:FF:000035
      label: Probable endonuclease LCL3
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 106.'
  - number: 253
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.270:FF:000006
      curie: CATH.FunFam:3.30.70.270:FF:000006
      label: Gag-Pol polyprotein
      negated: false
    - condition_type: TAXON
      value: Retroviridae
      curie: NCBITaxon:11632
      label: Retroviridae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 791.'
  - number: 254
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1040:FF:000004
      curie: CATH.FunFam:1.10.287.1040:FF:000004
      label: Exodeoxyribonuclease 7 small subunit
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 20. 20 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 285.'
  - number: 255
    conditions:
    - condition_type: FUNFAM
      value: 3.90.320.10:FF:000006
      curie: CATH.FunFam:3.90.320.10:FF:000006
      label: ATP-dependent helicase/deoxyribonuclease subunit B
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 20. 20 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 188.'
  - number: 256
    conditions:
    - condition_type: FUNFAM
      value: 3.60.10.10:FF:000037
      curie: CATH.FunFam:3.60.10.10:FF:000037
      label: Glucose-repressible alcohol dehydrogenase transcriptional effector
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 19. 19 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1241.'
  - number: 257
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.270:FF:000020
      curie: CATH.FunFam:3.30.70.270:FF:000020
      label: Transposon Tf2-6 polyprotein-like Protein
      negated: false
    - condition_type: TAXON
      value: Orthoretrovirinae
      curie: NCBITaxon:327045
      label: Orthoretrovirinae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 138.'
  - number: 258
    conditions:
    - condition_type: FUNFAM
      value: 3.40.1310.20:FF:000001
      curie: CATH.FunFam:3.40.1310.20:FF:000001
      label: Replication-associated protein
      negated: false
    - condition_type: TAXON
      value: Floreoviria
      curie: NCBITaxon:2731342
      label: Floreoviria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 906.'
  - number: 259
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000078
      curie: CATH.FunFam:3.30.420.10:FF:000078
      label: Ribonuclease HII
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 321.'
  - number: 260
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.10:FF:000001
      curie: CATH.FunFam:2.30.30.10:FF:000001
      label: POL polyprotein
      negated: false
    - condition_type: TAXON
      value: Lentivirus
      curie: NCBITaxon:11646
      label: Lentivirus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 17. 17 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2552.'
  - number: 261
    conditions:
    - condition_type: FUNFAM
      value: 3.30.1370.110:FF:000007
      curie: CATH.FunFam:3.30.1370.110:FF:000007
      label: Endonuclease MutS2
      negated: false
    - condition_type: TAXON
      value: Clostridia
      curie: NCBITaxon:186801
      label: Clostridia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 17. 17 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 137.'
  - number: 262
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3210.10:FF:000013
      curie: CATH.FunFam:1.10.3210.10:FF:000013
      label: Ribonuclease Y
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 17. 17 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2281.'
  - number: 263
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.12390:FF:000005
      curie: CATH.FunFam:3.40.50.12390:FF:000005
      label: 5'-3' exoribonuclease 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 17. 17 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1600.'
  - number: 264
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1040:FF:000002
      curie: CATH.FunFam:1.10.287.1040:FF:000002
      label: Exodeoxyribonuclease 7 small subunit
      negated: false
    - condition_type: TAXON
      value: Bacillaceae
      curie: NCBITaxon:186817
      label: Bacillaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 44.'
  - number: 265
    conditions:
    - condition_type: FUNFAM
      value: 3.30.1370.110:FF:000004
      curie: CATH.FunFam:3.30.1370.110:FF:000004
      label: Endonuclease MutS2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 927.'
  - number: 266
    conditions:
    - condition_type: FUNFAM
      value: 3.40.1360.10:FF:000006
      curie: CATH.FunFam:3.40.1360.10:FF:000006
      label: Ribonuclease M5
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2245.'
  - number: 267
    conditions:
    - condition_type: FUNFAM
      value: 3.30.1370.110:FF:000006
      curie: CATH.FunFam:3.30.1370.110:FF:000006
      label: Endonuclease MutS2
      negated: false
    - condition_type: TAXON
      value: Staphylococcaceae
      curie: NCBITaxon:90964
      label: Staphylococcaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 17.'
  - number: 268
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000307
      curie: CATH.FunFam:1.10.10.10:FF:000307
      label: Crossover junction endonuclease MUS81
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2142.'
  - number: 269
    conditions:
    - condition_type: FUNFAM
      value: 3.10.20.370:FF:000003
      curie: CATH.FunFam:3.10.20.370:FF:000003
      label: Transposon Tf2-6 polyprotein
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.270:FF:000003
      curie: CATH.FunFam:3.30.70.270:FF:000003
      label: Transposon Ty3-G Gag-Pol polyprotein
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.270:FF:000045
      curie: CATH.FunFam:3.30.70.270:FF:000045
      label: Transposon Tf2-7 polyprotein
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 14.'
  - number: 270
    conditions:
    - condition_type: FUNFAM
      value: 1.10.1520.10:FF:000004
      curie: CATH.FunFam:1.10.1520.10:FF:000004
      label: Endoribonuclease dicer-like 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4538.'
  - number: 271
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.690:FF:000001
      curie: CATH.FunFam:1.10.287.690:FF:000001
      label: DNA polymerase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 3581.'
  - number: 272
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1040:FF:000006
      curie: CATH.FunFam:1.10.287.1040:FF:000006
      label: Exodeoxyribonuclease 7 small subunit
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 14.'
  - number: 273
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000012
      curie: CATH.FunFam:3.30.420.10:FF:000012
      label: DNA polymerase III subunit epsilon
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 6850.'
  - number: 274
    conditions:
    - condition_type: FUNFAM
      value: 3.90.730.10:FF:000004
      curie: CATH.FunFam:3.90.730.10:FF:000004
      label: Ribonuclease T2-like
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1261.'
  - number: 275
    conditions:
    - condition_type: FUNFAM
      value: 3.30.230.70:FF:000004
      curie: CATH.FunFam:3.30.230.70:FF:000004
      label: Exosome complex component Rrp41
      negated: false
    - condition_type: TAXON
      value: Methanobacteriati
      curie: NCBITaxon:3366610
      label: Methanobacteriati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 162.'
  - number: 276
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000094
      curie: CATH.FunFam:3.30.420.10:FF:000094
      label: Gag-Pol polyprotein
      negated: false
    - condition_type: TAXON
      value: Gammaretrovirus
      curie: NCBITaxon:153135
      label: Gammaretrovirus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 49.'
  - number: 277
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.10:FF:000104
      curie: CATH.FunFam:3.30.420.10:FF:000104
      label: Werner Syndrome-like exonuclease
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 79.'
  - number: 278
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000708
      curie: CATH.FunFam:3.40.50.300:FF:000708
      label: ATP-dependent RNA helicase DDX1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1508.'
  - number: 279
    conditions:
    - condition_type: FUNFAM
      value: 3.60.21.10:FF:000011
      curie: CATH.FunFam:3.60.21.10:FF:000011
      label: Double-strand break repair protein
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2934.'
  - number: 280
    conditions:
    - condition_type: FUNFAM
      value: 1.10.1520.10:FF:000005
      curie: CATH.FunFam:1.10.1520.10:FF:000005
      label: Putative endoribonuclease dicer
      negated: false
    - condition_type: FUNFAM
      value: 2.170.260.10:FF:000002
      curie: CATH.FunFam:2.170.260.10:FF:000002
      label: Putative Endoribonuclease Dicer
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1505.'
  - number: 281
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1040:FF:000003
      curie: CATH.FunFam:1.10.287.1040:FF:000003
      label: Exodeoxyribonuclease 7 small subunit
      negated: false
    - condition_type: TAXON
      value: Streptococcaceae
      curie: NCBITaxon:1300
      label: Streptococcaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 29.'
  - number: 282
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.20:FF:000011
      curie: CATH.FunFam:1.10.150.20:FF:000011
      label: exonuclease 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 4054.'
  - number: 283
    conditions:
    - condition_type: FUNFAM
      value: 3.60.10.10:FF:000002
      curie: CATH.FunFam:3.60.10.10:FF:000002
      label: CCR4-NOT transcription complex subunit 6 like
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 2676.'
  - number: 284
    conditions:
    - condition_type: FUNFAM
      value: 1.10.132.60:FF:000011
      curie: CATH.FunFam:1.10.132.60:FF:000011
      label: DNA polymerase catalytic subunit
      negated: false
    - condition_type: TAXON
      value: Alphaherpesvirinae
      curie: NCBITaxon:10293
      label: Alphaherpesvirinae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 215.'
  - number: 285
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:001139
      curie: CATH.FunFam:3.40.50.300:FF:001139
      label: Orf1ab polyprotein
      negated: false
    - condition_type: TAXON
      value: Cornidovirineae
      curie: NCBITaxon:2499399
      label: Cornidovirineae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 481.'
  - number: 286
    conditions:
    - condition_type: FUNFAM
      value: 3.60.10.10:FF:000035
      curie: CATH.FunFam:3.60.10.10:FF:000035
      label: Deoxyribonuclease
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 354.'
  - number: 287
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.110:FF:000001
      curie: CATH.FunFam:1.10.150.110:FF:000001
      label: Putative Crossover junction endonuclease MUS81
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry keyword KW-0540 Nuclease. UniProtKB
      entries matching: 1821.'
  go_annotations: []
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 1024331
  created_date: '2020-05-12'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 538
review_summary: The first 287 of 538 live condition sets (CS1 to CS287) were queried against Swiss-Prot on 2026-11-09;
  the remaining 251 were not examined. Every one of the 287 sets has reviewed matches, and every reviewed match
  inspected carries the keyword Nuclease (17216 matches summed over sets, up to 500 inspected per set). TrEMBL matches
  were not inspected. Because nearly half of the sets were not examined, no verdict is given.
action: UNDECIDED
action_rationale: All 287 sets examined are supported by curated Swiss-Prot keywords and no false positive was found,
  but 251 sets remain unexamined.
annotation_assessments:
- annotation_kind: KEYWORD
  value: KW-0540
  label: Nuclease
  assessment: UNDECIDED
  notes: '287 of 538 sets examined; in each, all inspected Swiss-Prot matches carry KW-0540. Rule statistics: 1024331
    unreviewed proteins.'
corrections:
- date: '2026-11-10'
  withdrawn_claim: The rule should be removed because 532 condition sets are 44 times a recommended limit of 12.
  correction: Set count is not evidence about any annotation. The limit of 12 is a setting of the overlap-analysis
    script.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'Live rule: 538 condition sets (2026-11-09)'
  - '287 sets queried: all inspected Swiss-Prot matches carry KW-0540'
- date: '2026-11-10'
  withdrawn_claim: 371 unique InterPro domains create massive false positive risk because many of them appear in
    non-nuclease proteins.
  correction: Most sets are conjunctions and cannot be judged one domain at a time, and no non-nuclease match was
    shown. In the sets examined none was found among reviewed entries.
  error_type: CONJUNCTION_IGNORED
  evidence:
  - 'Live rule: 326 of 538 sets have two or more conditions'
  - 'CS1 to CS287: 0 reviewed matches without KW-0540'
- date: '2026-11-10'
  withdrawn_claim: The rule has no taxonomic restrictions.
  correction: 153 live sets carry a taxon condition.
  error_type: UNEXAMINED_RULE
  evidence:
  - 'Live rule (2026-11-09): 153 of 538 sets include a taxon condition, e.g. CS12 Bacillati, CS17 Gammaproteobacteria'
- date: '2026-11-10'
  withdrawn_claim: The keyword Nuclease is vague, and the rule is redundant with InterPro2GO mappings.
  correction: A general keyword is not a wrong one, and redundancy was asserted without any coverage figure; a redundant
    annotation is in any case not an incorrect one.
  error_type: GENERAL_IS_NOT_WRONG
  evidence:
  - 'Live rule annotation: keyword KW-0540 Nuclease'
- date: '2026-11-10'
  withdrawn_claim: Literature support is weak.
  correction: No literature was consulted; the supporting quote was a placeholder.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - 'Earlier version of this file: supporting_text "TODO - placeholder for literature analysis"'