ARBA00022806

id: ARBA00022806
description: >-
  ARBA rule assigning the UniProt keyword Helicase (KW-0347) through 335 alternative condition sets
  built from InterPro, PANTHER and taxon conditions.
status: IN_PROGRESS
rule_type: ARBA
rule:
  rule_id: ARBA00022806
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR014014
      curie: InterPro:IPR014014
      label: RNA helicase, DEAD-box type, Q motif
      negated: false
    - condition_type: INTERPRO
      value: IPR027417
      curie: InterPro:IPR027417
      label: P-loop containing nucleoside triphosphate hydrolase
      negated: false
    notes: DEAD-box Q motif within the P-loop NTPase superfamily.
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR000629
      curie: InterPro:IPR000629
      label: ATP-dependent RNA helicase DEAD-box, conserved site
      negated: false
    - condition_type: INTERPRO
      value: IPR001650
      curie: InterPro:IPR001650
      label: Helicase, C-terminal domain-like
      negated: false
    - condition_type: INTERPRO
      value: IPR011545
      curie: InterPro:IPR011545
      label: DEAD/DEAH-box helicase domain
      negated: false
    notes: DEAD-box conserved site with both helicase core domains.
  go_annotations: []
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 753214
  created_date: '2020-05-12'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 335
review_summary: >-
  The live rule has 335 condition sets, 91 of which carry a taxon condition; UniProt reports 753,214
  unreviewed proteins. Two sets (1 and 2) were read: both are DEAD-box helicase signatures by their
  official InterPro names. No set was checked against annotated proteins and 333 were not examined,
  so no verdict is given.
action: UNDECIDED
action_rationale: >-
  Two of 335 condition sets were read and none was checked against annotated proteins. No defect with
  a named set or protein is known.
suggested_modifications:
- >-
  Check a sample of condition sets against Swiss-Prot use of KW-0347 before recommending any change.
annotation_assessments:
- annotation_kind: KEYWORD
  value: KW-0347
  label: Helicase
  assessment: UNDECIDED
  matched_protein_count: 753214
  notes: >-
    matched_protein_count is the unreviewedProteinCount from rest.uniprot.org/arba/ARBA00022806 on
    2026-11-09. InterPro API names: IPR014014 RNA helicase, DEAD-box type, Q motif; IPR000629 ATP-dependent
    RNA helicase DEAD-box, conserved site; IPR001650 Helicase, C-terminal domain-like; IPR011545 DEAD/DEAH-box
    helicase domain. No matched protein was checked.
corrections:
- date: '2026-11-10'
  withdrawn_claim: The rule lacks taxonomic restrictions, which is appropriate.
  correction: >-
    91 of the 335 live condition sets carry a taxon condition; the previous text had recorded no condition
    sets.
  error_type: TAXON_MISREAD
  evidence:
  - Count over conditionSets of rest.uniprot.org/arba/ARBA00022806, 2026-11-09
  - 'Previous file recorded condition_sets: []'
- date: '2026-11-10'
  withdrawn_claim: The rule should be modified by consolidating functionally redundant condition sets.
  correction: >-
    The same text assessed condition overlap as none and stated the rule lacks redundancy; no redundant
    pair was named.
  error_type: OTHER
  evidence:
  - 'Previous condition_overlap assessment: NONE'
- date: '2026-11-10'
  withdrawn_claim: 355 condition sets are excessive, so the rule needs modification.
  correction: Rule size is not evidence about correctness; the live rule has 335 sets.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'rest.uniprot.org/arba/ARBA00022806, 2026-11-09: 335 sets'
- date: '2026-11-10'
  withdrawn_claim: Each InterPro entry appears in only one or two condition sets, so the sets do not
    overlap.
  correction: >-
    How often an identifier is reused says nothing about how many proteins two sets share; no protein
    overlap was measured.
  error_type: UNEXAMINED_RULE
  evidence:
  - No pairwise protein counts were recorded