ARBA rule assigning the UniProt keyword Tyrosine-protein kinase (KW-0829) through 100 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions.
Condition-set counts describe the sets recorded in this review, which may omit the full rule.
No domain overlap table is shown: the cached overlap analysis for this version of the review is not available.
Run just analyze-rule ARBA00023137 and re-render to add it.
The live rule has 100 condition sets; UniProt reports 177,623 unreviewed proteins. Five sets were examined. The bacterial and plant sets (sets 37, 86, 92, 95) match Swiss-Prot proteins that carry the Tyrosine-protein kinase keyword by curation. Swiss-Prot also gives this keyword to dual-specificity kinases such as MAP2K1 (Q02750). No false positive has been identified. 95 sets were not examined, so no verdict is given.
Five of 100 condition sets were examined; the four checked against Swiss-Prot agree with curated keyword use. The rest of the rule was not examined.
matched_protein_count is the unreviewedProteinCount from rest.uniprot.org/arba/ARBA00023137 on 2026-11-09. Each example is a reviewed entry that carries KW-0829 and belongs to a FunFam used by a taxon-restricted condition set: P76387 (FunFam 3.40.50.300:FF:000527), P9WPI9 (3.40.50.1000:FF:000022), Q8L4H0 (1.10.510.10:FF:000531), Q9SSA4 and Q9FGB1 (1.10.510.10:FF:000310 with 3.30.200.20:FF:000034). Q02750 (MAP2K1, dual specificity) also carries KW-0829.
Protein kinase domain together with an SH2 domain and the Ser-Thr/Tyr kinase catalytic domain.
Matches E. coli Wzc (P76387), which carries KW-0829 in Swiss-Prot.
Matches M. tuberculosis PtkA (P9WPI9, EC 2.7.10.-), which carries KW-0829 in Swiss-Prot.
Matches Arabidopsis CBC1 (Q9SSA4) and CBC2 (Q9FGB1), which carry both the Serine/threonine-protein kinase and Tyrosine-protein kinase keywords in Swiss-Prot.
Contains Arabidopsis WEE1 (Q8L4H0, EC 2.7.10.2), which carries KW-0829 in Swiss-Prot.
id: ARBA00023137
description: >-
ARBA rule assigning the UniProt keyword Tyrosine-protein kinase (KW-0829) through 100 alternative
condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions.
status: IN_PROGRESS
rule_type: ARBA
rule:
rule_id: ARBA00023137
condition_sets:
- number: 2
conditions:
- condition_type: INTERPRO
value: IPR000719
curie: InterPro:IPR000719
label: Protein kinase domain
negated: false
- condition_type: INTERPRO
value: IPR000980
curie: InterPro:IPR000980
label: SH2 domain
negated: false
- condition_type: INTERPRO
value: IPR001245
curie: InterPro:IPR001245
label: Serine-threonine/tyrosine-protein kinase, catalytic domain
negated: false
notes: >-
Protein kinase domain together with an SH2 domain and the Ser-Thr/Tyr kinase catalytic domain.
- number: 37
conditions:
- condition_type: FUNFAM
value: 3.40.50.300:FF:000527
curie: CATH.FunFam:3.40.50.300:FF:000527
label: Tyrosine-protein kinase etk
negated: false
- condition_type: TAXON
value: Bacteria
label: Bacteria
negated: false
notes: Matches E. coli Wzc (P76387), which carries KW-0829 in Swiss-Prot.
- number: 86
conditions:
- condition_type: FUNFAM
value: 3.40.50.1000:FF:000022
curie: CATH.FunFam:3.40.50.1000:FF:000022
label: Phosphoglycolate phosphatase
negated: false
- condition_type: TAXON
value: Actinomycetota
label: Actinomycetota
negated: false
notes: Matches M. tuberculosis PtkA (P9WPI9, EC 2.7.10.-), which carries KW-0829 in Swiss-Prot.
- number: 92
conditions:
- condition_type: FUNFAM
value: 1.10.510.10:FF:000310
curie: CATH.FunFam:1.10.510.10:FF:000310
label: Serine/threonine-protein kinase HT1
negated: false
- condition_type: FUNFAM
value: 3.30.200.20:FF:000034
curie: CATH.FunFam:3.30.200.20:FF:000034
label: Kinase suppressor of Ras 1
negated: false
- condition_type: TAXON
value: Viridiplantae
label: Viridiplantae
negated: false
notes: >-
Matches Arabidopsis CBC1 (Q9SSA4) and CBC2 (Q9FGB1), which carry both the Serine/threonine-protein
kinase and Tyrosine-protein kinase keywords in Swiss-Prot.
- number: 95
conditions:
- condition_type: FUNFAM
value: 1.10.510.10:FF:000531
curie: CATH.FunFam:1.10.510.10:FF:000531
negated: false
- condition_type: FUNFAM
value: 3.30.200.20:FF:000356
curie: CATH.FunFam:3.30.200.20:FF:000356
negated: false
- condition_type: TAXON
value: Embryophyta
label: Embryophyta
negated: false
notes: Contains Arabidopsis WEE1 (Q8L4H0, EC 2.7.10.2), which carries KW-0829 in Swiss-Prot.
go_annotations: []
entries: []
reviewed_protein_count: 0
unreviewed_protein_count: 177623
created_date: '2020-05-12'
modified_date: '2026-07-18'
retrieved_date: '2026-11-09'
source_condition_set_count: 100
review_summary: >-
The live rule has 100 condition sets; UniProt reports 177,623 unreviewed proteins. Five sets were
examined. The bacterial and plant sets (sets 37, 86, 92, 95) match Swiss-Prot proteins that carry
the Tyrosine-protein kinase keyword by curation. Swiss-Prot also gives this keyword to dual-specificity
kinases such as MAP2K1 (Q02750). No false positive has been identified. 95 sets were not examined,
so no verdict is given.
action: UNDECIDED
action_rationale: >-
Five of 100 condition sets were examined; the four checked against Swiss-Prot agree with curated
keyword use. The rest of the rule was not examined.
suggested_modifications:
- >-
Check the remaining condition sets against Swiss-Prot use of KW-0829 before recommending any change.
annotation_assessments:
- annotation_kind: KEYWORD
value: KW-0829
label: Tyrosine-protein kinase
assessment: UNDECIDED
matched_protein_count: 177623
correct_examples:
- P76387
- P9WPI9
- Q8L4H0
- Q9SSA4
- Q9FGB1
notes: >-
matched_protein_count is the unreviewedProteinCount from rest.uniprot.org/arba/ARBA00023137 on
2026-11-09. Each example is a reviewed entry that carries KW-0829 and belongs to a FunFam used
by a taxon-restricted condition set: P76387 (FunFam 3.40.50.300:FF:000527), P9WPI9 (3.40.50.1000:FF:000022),
Q8L4H0 (1.10.510.10:FF:000531), Q9SSA4 and Q9FGB1 (1.10.510.10:FF:000310 with 3.30.200.20:FF:000034).
Q02750 (MAP2K1, dual specificity) also carries KW-0829.
corrections:
- date: '2026-11-10'
withdrawn_claim: >-
Bacterial kinases, plant kinases and dual-specificity kinases should not receive the Tyrosine-protein
kinase keyword.
correction: Swiss-Prot curators assign KW-0829 to exactly these proteins.
error_type: REFUTED_BY_CURATED_ANNOTATION
evidence:
- UniProtKB P76387 (WZC_ECOLI) keywords include Tyrosine-protein kinase
- UniProtKB P9WPI9 (PTKA_MYCTU) keywords include Tyrosine-protein kinase
- >-
UniProtKB Q8L4H0 (WEE1_ARATH), Q9SSA4 (CBC1_ARATH), Q9FGB1 (CBC2_ARATH) keywords include Tyrosine-protein
kinase
- UniProtKB Q02750 (MP2K1_HUMAN) keywords include Tyrosine-protein kinase
- date: '2026-11-10'
withdrawn_claim: IPR000719 (Protein kinase domain) is promiscuous, so the rule over-annotates.
correction: >-
In the rule IPR000719 is used only inside a conjunction with an SH2 domain and the Ser-Thr/Tyr
kinase catalytic domain.
error_type: CONJUNCTION_IGNORED
evidence:
- 'Live set 2: IPR000719 AND IPR000980 AND IPR001245'
- date: '2026-11-10'
withdrawn_claim: >-
Only 17 of 98 condition sets have taxonomic restrictions, leading to inappropriate cross-lineage
annotations.
correction: >-
The absence of a taxon condition is not evidence of a wrong annotation, and no wrongly annotated
protein was named. The live rule has 19 taxon-restricted sets of 100.
error_type: TAXON_MISREAD
evidence:
- 'rest.uniprot.org/arba/ARBA00023137, 2026-11-09: 100 sets, 19 with a taxon condition'
- date: '2026-11-10'
withdrawn_claim: 98 condition sets exceed a maintainability limit of 12, so the rule should be deprecated.
correction: Rule size is not evidence about correctness.
error_type: SIZE_AS_EVIDENCE
evidence:
- No protein-level evidence was given
- date: '2026-11-10'
withdrawn_claim: A keyword instead of a GO term is a defect of the rule.
correction: >-
The consequent is a keyword by design; this says nothing about whether the keyword is right for
the matched proteins.
error_type: GENERAL_IS_NOT_WRONG
evidence:
- 'Live annotation: keyword KW-0829'