Assigns the UniProt keyword KW-0456 Lyase through 908 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition.
Condition-set counts describe the sets recorded in this review, which may omit the full rule.
No domain overlap table is shown: the cached overlap analysis for this version of the review is not available.
Run just analyze-rule ARBA00023239 and re-render to add it.
None of the 908 live condition sets has been examined, and no protein wrongly given the keyword has been identified. The review is open.
There is no evidence in hand for or against the rule's correctness.
No condition set examined.
id: ARBA00023239
description: Assigns the UniProt keyword KW-0456 Lyase through 908 alternative condition sets of InterPro,
PANTHER and CATH FunFam signatures, some with a taxon condition.
status: IN_PROGRESS
rule_type: ARBA
rule:
rule_id: ARBA00023239
condition_sets: []
entries: []
reviewed_protein_count: 0
unreviewed_protein_count: 2276972
created_date: '2020-05-12'
modified_date: '2026-07-18'
retrieved_date: '2026-11-09'
source_condition_set_count: 908
review_summary: None of the 908 live condition sets has been examined, and no protein wrongly given the
keyword has been identified. The review is open.
action: UNDECIDED
action_rationale: There is no evidence in hand for or against the rule's correctness.
annotation_assessments:
- annotation_kind: KEYWORD
value: KW-0456
label: Lyase
assessment: UNDECIDED
notes: No condition set examined.
corrections:
- date: '2026-11-10'
withdrawn_claim: More than 2.5 million matched proteins with zero reviewed entries shows the rule captures
everything lyase-related without discrimination.
correction: UniProt reports reviewedProteinCount 0 for ARBA rules in general, so the zero carries no
information about this rule.
error_type: OTHER
evidence:
- 'rest.uniprot.org/arba statistics, 2026-11-09: reviewedProteinCount is 0 for all 14 live rules fetched
for this batch (ARBA00001096, ARBA00023002, ARBA00023239, ARBA00026572, ARBA00026647, ARBA00026698,
ARBA00027169, ARBA00027651, ARBA00028334, ARBA00047230, ARBA00047239, ARBA00067001, ARBA00085883,
ARBA00089180)'
- date: '2026-11-10'
withdrawn_claim: 894 condition sets is 75 times the limit of 12 and a fatal design flaw; the rule should
be deprecated.
correction: The limit of 12 is the default of this repository's overlap-analysis tool. The number of
alternative sets is not evidence that any of them is wrong.
error_type: SIZE_AS_EVIDENCE
evidence:
- 'src/ai_gene_review/etl/rule_analysis.py: max_condition_sets: int = 12 (default of the overlap-analysis
tool)'
- date: '2026-11-10'
withdrawn_claim: Basic inspection reveals many redundant condition sets.
correction: The review recorded no condition sets, so no inspection result can be checked.
error_type: UNEXAMINED_RULE
evidence:
- 'Old review: rule.condition_sets empty'
- date: '2026-11-10'
withdrawn_claim: The keyword "Lyase" is too generic, so the rule should be deprecated.
correction: A correct general keyword is not a wrong annotation.
error_type: GENERAL_IS_NOT_WRONG
evidence:
- 'rest.uniprot.org/arba/ARBA00023239 annotations: keyword KW-0456 Lyase'
- date: '2026-11-10'
withdrawn_claim: geneontology/go-annotation issue 6035 documents pipeline performance problems caused
by this rule.
correction: The issue could not be retrieved and checked, and performance is not a question of annotation
correctness.
error_type: UNSUPPORTED_SOURCE
evidence:
- Issue not accessible from this review environment (2026-11-09)