ARBA00026698 vacuolar transport (GO:0007034)

View original ARBA rule on UniProt

Type: ARBA
Status: COMPLETE
Action: ACCEPT
Confidence: 0.80

Description

Assigns GO:0007034 vacuolar transport through 40 alternative condition sets, each a conjunction of InterPro or CATH FunFam signatures with a taxon. The sets cover ESCRT-III/Snf7-family proteins, ESCRT-I and ESCRT-II subunits, Vps4, sortilin/Vps10 and plant vacuolar sorting receptors, vacuolar syntaxins, GGA/VHS adaptors, NEDD4/Rsp5-type ubiquitin ligases and a few other families.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
40
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00026698 and re-render to add it.

Review Summary

All 40 live condition sets were examined. 26 sets match Swiss-Prot entries, and in every one of them at least one matched entry carries GO:0007034 or a descendant with experimental evidence; no matched Swiss-Prot entry lacks the term. The other 14 sets (numbers 2, 4, 10, 12, 15, 17, 26, 28, 32, 34, 35, 37, 38, 40) are Archaea or Bacteria copies of eukaryotic sets and match no UniProtKB entry, so they annotate nothing. The first InterPro condition, IPR005024 (Vacuolar-sorting protein SNF7-like), is itself mapped to GO:0007034 by InterPro2GO.

Action Rationale

Each set that matches any protein selects a family with experimentally annotated members in vacuolar or lysosomal transport, and the term is their common parent. The empty Archaea and Bacteria sets are harmless.

GO Annotations

GO:0007034 - vacuolar transport
Aspect: BP

Annotation Assessments

CORRECT GO_TERM GO:0007034 - vacuolar transport
Matched proteins: ; incorrect:
Correct examples: Q96FZ7, Q9BY43, Q9HD42, Q9NZZ3, Q9UQN3, Q9Y3E7, Q7LBR1, O43633, Q96CF2, Q8WUX9, Q9H444, P93026, Q56ZQ3, O80977, P40890, P40438, P32319, O42930, Q2TVY7, Q99176, P25604, Q02767, Q7Z992, O13872, P52917, Q5AG40, Q09803, P39940, Q92462, Q5BDP1, Q9SWH4, O65359, Q9SUJ1, Q86H98, Q9P7F7, Q03407, Q12236, P93654, Q39233, P38817

Per-set receipts are in rule.condition_sets[].notes. Accessions listed are Swiss-Prot matches with experimental evidence for GO:0007034 or a descendant in QuickGO (first 40).

Rule Definition

Condition Sets

Condition Set 1

2 condition(s)
Notes:

UniProtKB query, November 2026: 19 Swiss-Prot and 672 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 11 with experimental evidence, 2 with other manual evidence only, 6 with IEA only, 0 with none. Examples: Q96FZ7 (CHMP6_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323; Q9BY43 (CHM4A_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323; Q9HD42 (CHM1A_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323.

Condition Set 2

4 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 3

4 condition(s)
Notes:

UniProtKB query, November 2026: 8 Swiss-Prot and 1867 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 4 with other manual evidence only, 1 with IEA only, 0 with none. Examples: P93026 (VSR1_ARATH) GO:0006623 protein targeting to vacuole, IDA, PMID:34983843; Q56ZQ3 (VSR4_ARATH) GO:0006623 protein targeting to vacuole, IGI, PMID:20807215; O80977 (VSR3_ARATH) GO:0006623 protein targeting to vacuole, IMP, PMID:20807215.

Condition Set 4

4 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 5

3 condition(s)
Notes:

UniProtKB query, November 2026: 63 Swiss-Prot and 1526 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 8 with other manual evidence only, 50 with IEA only, 0 with none. Examples: P40890 (VTH2_YEAST) GO:0006623 protein targeting to vacuole, IGI, PMID:8636229; P40438 (VTH1_YEAST) GO:0006896 Golgi to vacuole transport, IGI, PMID:8662642; P32319 (VPS10_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:8187177.

Condition Set 6

2 condition(s)
Notes:

UniProtKB query, November 2026: 5 Swiss-Prot and 3734 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q99176 (SRN2_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:11511343; P25604 (STP22_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:11511343; Q02767 (VPS28_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:11511343.

Condition Set 7

2 condition(s)
Notes:

UniProtKB query, November 2026: 8 Swiss-Prot and 2404 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 4 with other manual evidence only, 1 with IEA only, 0 with none. Examples: P93026 (VSR1_ARATH) GO:0006623 protein targeting to vacuole, IDA, PMID:34983843; O80977 (VSR3_ARATH) GO:0006623 protein targeting to vacuole, IMP, PMID:20807215; Q56ZQ3 (VSR4_ARATH) GO:0006623 protein targeting to vacuole, IGI, PMID:20807215.

Condition Set 8

2 condition(s)
Notes:

UniProtKB query, November 2026: 63 Swiss-Prot and 1450 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 8 with other manual evidence only, 50 with IEA only, 0 with none. Examples: P40438 (VTH1_YEAST) GO:0006896 Golgi to vacuole transport, IGI, PMID:8662642; P40890 (VTH2_YEAST) GO:0006623 protein targeting to vacuole, IGI, PMID:8636229; P32319 (VPS10_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:8187177.

Condition Set 9

3 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 1352 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P52917 (VPS4_YEAST) GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway, IMP, PMID:16505166; Q5AG40 (VPS4_CANAL) GO:0006623 protein targeting to vacuole, IMP, PMID:17506830; Q09803 (VPS4_SCHPO) GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IMP, PMID:17660439.

Condition Set 10

4 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 11

4 condition(s)
Notes:

UniProtKB query, November 2026: 12 Swiss-Prot and 1361 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 6 with other manual evidence only, 3 with IEA only, 0 with none. Examples: P39940 (RSP5_YEAST) GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway, IMP, PMID:17182849; Q92462 (PUB1_SCHPO) GO:0120113 cytoplasm to vacuole targeting by the NVT pathway, IMP, PMID:26365378; Q5BDP1 (RSP5_ASPN4) GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IDA, PMID:20002879.

Condition Set 12

4 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 13

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 141 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q9BY43 (CHM4A_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323; Q9H444 (CHM4B_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323; Q96CF2 (CHM4C_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323.

Condition Set 14

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 874 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q9SWH4 (SYP42_ARATH) GO:0006896 Golgi to vacuole transport, IMP, PMID:11739776; O65359 (SYP41_ARATH) GO:0006896 Golgi to vacuole transport, IMP, PMID:11739776; Q9SUJ1 (SYP43_ARATH) GO:0006896 Golgi to vacuole transport, IMP, PMID:11739776.

Condition Set 15

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 16

2 condition(s)
Notes:

UniProtKB query, November 2026: 6 Swiss-Prot and 441 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 3 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q8WUX9 (CHMP7_HUMAN) GO:0045324 late endosome to vacuole transport, IMP, PMID:16856878; Q86H98 (CHMP4_DICDI) GO:0008333 endosome to lysosome transport, IMP, PMID:15708561; Q9P7F7 (SNF7_SCHPO) GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IMP, PMID:17660439.

Condition Set 17

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 18

3 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 130 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 1 with IEA only, 0 with none. Examples: Q03407 (PKH1_YEAST) GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway, IGI, PMID:22918958; Q12236 (PKH2_YEAST) GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway, IGI, PMID:22918958.

Condition Set 19

3 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 1135 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P93654 (SYP22_ARATH) GO:0045324 late endosome to vacuole transport, IGI, PMID:29749929; Q39233 (SYP21_ARATH) GO:0006623 protein targeting to vacuole, IDA, PMID:17662029.

Condition Set 20

3 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 40 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P38817 (GGA2_YEAST) GO:0006896 Golgi to vacuole transport, IGI, PMID:10747088; Q06336 (GGA1_YEAST) GO:0006896 Golgi to vacuole transport, IGI, PMID:10747088.

Condition Set 21

3 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 13 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P17046 (LAMP2_RAT) GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy, IGI, PMID:18644871; P17047 (LAMP2_MOUSE) GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy, IMP, PMID:27628032.

Condition Set 22

2 condition(s)
Notes:

UniProtKB query, November 2026: 4 Swiss-Prot and 1098 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 2 with IEA only, 0 with none. Examples: Q5VIR6 (VPS53_HUMAN) GO:0007041 lysosomal transport, IMP, PMID:25799061; Q8CCB4 (VPS53_MOUSE) GO:0006622 protein targeting to lysosome, IMP, PMID:28658628.

Condition Set 23

2 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 149 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q96ED9 (HOOK2_HUMAN) GO:0008333 endosome to lysosome transport, IMP, PMID:18799622; Q9UJC3 (HOOK1_HUMAN) GO:0008333 endosome to lysosome transport, IMP, PMID:18799622.

Condition Set 24

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 610 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 1 with IEA only, 0 with none. Examples: Q09500 (CTNS_CAEEL) GO:1904919 L-cystine transmembrane transport from lysosomal lumen to cytosol, IMP, PMID:22822152; Q9VCR7 (CTNS_DROME) GO:1904919 L-cystine transmembrane transport from lysosomal lumen to cytosol, IMP, PMID:35175796.

Condition Set 25

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 117 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 1 with IEA only, 0 with none. Examples: Q9UN37 (VPS4A_HUMAN) GO:0006622 protein targeting to lysosome, IMP, PMID:16973552; O75351 (VPS4B_HUMAN) GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway, IMP, PMID:15024011.

Condition Set 26

3 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 27

3 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 134 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: O01498 (STAM1_CAEEL) GO:0008333 endosome to lysosome transport, IMP, PMID:17581863; O74749 (HSE1_SCHPO) GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IMP, PMID:17660439.

Condition Set 28

3 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 29

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 116 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P20645 (MPRD_HUMAN) GO:0090160 Golgi to lysosome transport, IDA, PMID:10799489; P24668 (MPRD_MOUSE) GO:0007041 lysosomal transport, IDA, PMID:26370502.

Condition Set 30

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 1438 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence only, 0 with IEA only, 0 with none. Examples: O14617 (AP3D1_HUMAN) GO:0140916 zinc ion import into lysosome, IMP, PMID:17349999; O54774 (AP3D1_MOUSE) GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome, IDA, PMID:24217640.

Condition Set 31

2 condition(s)
Notes:

UniProtKB query, November 2026: 4 Swiss-Prot and 951 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 2 with IEA only, 0 with none. Examples: Q9SN68 (RAF2B_ARATH) GO:0045324 late endosome to vacuole transport, IMP, PMID:24824487; P31582 (RAF2A_ARATH) GO:0007034 vacuolar transport, IMP, PMID:12724533.

Condition Set 32

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 33

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 1382 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q12483 (SNF8_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:12194858; O94663 (SNF8_SCHPO) GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IMP, PMID:17660439.

Condition Set 34

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 35

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 36

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 31 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 1 with IEA only, 0 with none. Examples: P39929 (SNF7_YEAST) GO:0045324 late endosome to vacuole transport, IMP, PMID:9606181; Q5ABD0 (SNF7_CANAL) GO:0006623 protein targeting to vacuole, IMP, PMID:18974864.

Condition Set 37

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 38

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Condition Set 39

2 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 935 TrEMBL entries match. QuickGO, GO:0007034 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P31377 (STX8_YEAST) GO:0006896 Golgi to vacuole transport, IMP, PMID:12453154; O14222 (FSV1_SCHPO) GO:0006896 Golgi to vacuole transport, IGI, PMID:25378562.

Condition Set 40

2 condition(s)
Notes:

No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates nothing.

Assessments

STRONG

Curated experimental GO annotations on matched Swiss-Prot entries are listed per set in rule.condition_sets[].notes (QuickGO, November 2026), for example VPS10_YEAST GO:0006623 IMP PMID:8187177 (set 5), VPS4_YEAST GO:0045324 IMP PMID:9211789 (set 9) and SYP42_ARATH GO:0007034 IGI PMID:22307646 (set 14).

APPROPRIATE

The matched proteins are annotated to different children of GO:0007034 (for example GO:0006623 protein targeting to vacuole, GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway, GO:0045324 late endosome to vacuole transport, GO:0006896 Golgi to vacuole transport), so GO:0007034 is the common term across the sets.

Raw YAML

View Source YAML 
id: ARBA00026698
description: Assigns GO:0007034 vacuolar transport through 40 alternative condition sets, each a conjunction
  of InterPro or CATH FunFam signatures with a taxon. The sets cover ESCRT-III/Snf7-family proteins, ESCRT-I
  and ESCRT-II subunits, Vps4, sortilin/Vps10 and plant vacuolar sorting receptors, vacuolar syntaxins,
  GGA/VHS adaptors, NEDD4/Rsp5-type ubiquitin ligases and a few other families.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00026698
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR005024
      curie: InterPro:IPR005024
      label: Vacuolar-sorting protein SNF7-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: '9443'
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: 'UniProtKB query, November 2026: 19 Swiss-Prot and 672 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 11 with experimental evidence, 2 with other manual evidence
      only, 6 with IEA only, 0 with none. Examples: Q96FZ7 (CHMP6_HUMAN) GO:1902774 late endosome to lysosome
      transport, IMP, PMID:17984323; Q9BY43 (CHM4A_HUMAN) GO:1902774 late endosome to lysosome transport,
      IMP, PMID:17984323; Q9HD42 (CHM1A_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323.'
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR001881
      curie: InterPro:IPR001881
      label: EGF-like calcium-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003137
      curie: InterPro:IPR003137
      label: PA domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018097
      curie: InterPro:IPR018097
      label: EGF-like calcium-binding, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR001881
      curie: InterPro:IPR001881
      label: EGF-like calcium-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003137
      curie: InterPro:IPR003137
      label: PA domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018097
      curie: InterPro:IPR018097
      label: EGF-like calcium-binding, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 8 Swiss-Prot and 1867 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 4 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P93026 (VSR1_ARATH) GO:0006623 protein targeting to
      vacuole, IDA, PMID:34983843; Q56ZQ3 (VSR4_ARATH) GO:0006623 protein targeting to vacuole, IGI, PMID:20807215;
      O80977 (VSR3_ARATH) GO:0006623 protein targeting to vacuole, IMP, PMID:20807215.'
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR001881
      curie: InterPro:IPR001881
      label: EGF-like calcium-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR003137
      curie: InterPro:IPR003137
      label: PA domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018097
      curie: InterPro:IPR018097
      label: EGF-like calcium-binding, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR015943
      curie: InterPro:IPR015943
      label: WD40/YVTN repeat-like-containing domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR031777
      curie: InterPro:IPR031777
      label: Sortilin, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: '4751'
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'UniProtKB query, November 2026: 63 Swiss-Prot and 1526 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 8 with other manual evidence
      only, 50 with IEA only, 0 with none. Examples: P40890 (VTH2_YEAST) GO:0006623 protein targeting
      to vacuole, IGI, PMID:8636229; P40438 (VTH1_YEAST) GO:0006896 Golgi to vacuole transport, IGI, PMID:8662642;
      P32319 (VPS10_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:8187177.'
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR037202
      curie: InterPro:IPR037202
      label: ESCRT assembly domain
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: '451864'
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: 'UniProtKB query, November 2026: 5 Swiss-Prot and 3734 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q99176 (SRN2_YEAST) GO:0006623 protein targeting to
      vacuole, IMP, PMID:11511343; P25604 (STP22_YEAST) GO:0006623 protein targeting to vacuole, IMP,
      PMID:11511343; Q02767 (VPS28_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:11511343.'
  - number: 7
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000178
      curie: CATH.FUNFAM:2.10.25.10:FF:000178
      label: vacuolar-sorting receptor 1
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 8 Swiss-Prot and 2404 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 4 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P93026 (VSR1_ARATH) GO:0006623 protein targeting to
      vacuole, IDA, PMID:34983843; O80977 (VSR3_ARATH) GO:0006623 protein targeting to vacuole, IMP, PMID:20807215;
      Q56ZQ3 (VSR4_ARATH) GO:0006623 protein targeting to vacuole, IGI, PMID:20807215.'
  - number: 8
    conditions:
    - condition_type: FUNFAM
      value: 3.30.60.270:FF:000005
      curie: CATH.FUNFAM:3.30.60.270:FF:000005
      label: Sortilin
      negated: false
    - condition_type: TAXON
      value: '4751'
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'UniProtKB query, November 2026: 63 Swiss-Prot and 1450 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 8 with other manual evidence
      only, 50 with IEA only, 0 with none. Examples: P40438 (VTH1_YEAST) GO:0006896 Golgi to vacuole transport,
      IGI, PMID:8662642; P40890 (VTH2_YEAST) GO:0006623 protein targeting to vacuole, IGI, PMID:8636229;
      P32319 (VPS10_YEAST) GO:0006623 protein targeting to vacuole, IMP, PMID:8187177.'
  - number: 9
    conditions:
    - condition_type: FUNFAM
      value: 1.10.8.60:FF:000015
      curie: CATH.FUNFAM:1.10.8.60:FF:000015
      label: vacuolar protein sorting-associated protein 4A
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000043
      curie: CATH.FUNFAM:3.40.50.300:FF:000043
      label: Vacuolar protein sorting-associated protein 4
      negated: false
    - condition_type: TAXON
      value: '451864'
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 1352 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P52917 (VPS4_YEAST) GO:0032511 late endosome to vacuole
      transport via multivesicular body sorting pathway, IMP, PMID:16505166; Q5AG40 (VPS4_CANAL) GO:0006623
      protein targeting to vacuole, IMP, PMID:17506830; Q09803 (VPS4_SCHPO) GO:0043328 protein transport
      to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body
      sorting pathway, IMP, PMID:17660439.'
  - number: 10
    conditions:
    - condition_type: FUNFAM
      value: 2.20.70.10:FF:000011
      curie: CATH.FUNFAM:2.20.70.10:FF:000011
      label: E3 ubiquitin-protein ligase
      negated: false
    - condition_type: FUNFAM
      value: 3.30.2410.10:FF:000001
      curie: CATH.FUNFAM:3.30.2410.10:FF:000001
      label: E3 ubiquitin-protein ligase NEDD4-like
      negated: false
    - condition_type: FUNFAM
      value: 3.90.1750.10:FF:000005
      curie: CATH.FUNFAM:3.90.1750.10:FF:000005
      label: E3 ubiquitin-protein ligase
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 11
    conditions:
    - condition_type: FUNFAM
      value: 2.20.70.10:FF:000011
      curie: CATH.FUNFAM:2.20.70.10:FF:000011
      label: E3 ubiquitin-protein ligase
      negated: false
    - condition_type: FUNFAM
      value: 3.30.2410.10:FF:000001
      curie: CATH.FUNFAM:3.30.2410.10:FF:000001
      label: E3 ubiquitin-protein ligase NEDD4-like
      negated: false
    - condition_type: FUNFAM
      value: 3.90.1750.10:FF:000005
      curie: CATH.FUNFAM:3.90.1750.10:FF:000005
      label: E3 ubiquitin-protein ligase
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 12 Swiss-Prot and 1361 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 6 with other manual evidence
      only, 3 with IEA only, 0 with none. Examples: P39940 (RSP5_YEAST) GO:0032511 late endosome to vacuole
      transport via multivesicular body sorting pathway, IMP, PMID:17182849; Q92462 (PUB1_SCHPO) GO:0120113
      cytoplasm to vacuole targeting by the NVT pathway, IMP, PMID:26365378; Q5BDP1 (RSP5_ASPN4) GO:0043328
      protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular
      body sorting pathway, IDA, PMID:20002879.'
  - number: 12
    conditions:
    - condition_type: FUNFAM
      value: 2.20.70.10:FF:000011
      curie: CATH.FUNFAM:2.20.70.10:FF:000011
      label: E3 ubiquitin-protein ligase
      negated: false
    - condition_type: FUNFAM
      value: 3.30.2410.10:FF:000001
      curie: CATH.FUNFAM:3.30.2410.10:FF:000001
      label: E3 ubiquitin-protein ligase NEDD4-like
      negated: false
    - condition_type: FUNFAM
      value: 3.90.1750.10:FF:000005
      curie: CATH.FUNFAM:3.90.1750.10:FF:000005
      label: E3 ubiquitin-protein ligase
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 13
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000001
      curie: CATH.FUNFAM:1.10.287.1060:FF:000001
      label: Charged multivesicular body protein 4b
      negated: false
    - condition_type: TAXON
      value: '9443'
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 141 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q9BY43 (CHM4A_HUMAN) GO:1902774 late endosome to lysosome
      transport, IMP, PMID:17984323; Q9H444 (CHM4B_HUMAN) GO:1902774 late endosome to lysosome transport,
      IMP, PMID:17984323; Q96CF2 (CHM4C_HUMAN) GO:1902774 late endosome to lysosome transport, IMP, PMID:17984323.'
  - number: 14
    conditions:
    - condition_type: FUNFAM
      value: 1.20.58.70:FF:000010
      curie: CATH.FUNFAM:1.20.58.70:FF:000010
      label: Syntaxin-43
      negated: false
    - condition_type: TAXON
      value: '35493'
      curie: NCBITaxon:35493
      label: Streptophyta
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 874 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q9SWH4 (SYP42_ARATH) GO:0006896 Golgi to vacuole transport,
      IMP, PMID:11739776; O65359 (SYP41_ARATH) GO:0006896 Golgi to vacuole transport, IMP, PMID:11739776;
      Q9SUJ1 (SYP43_ARATH) GO:0006896 Golgi to vacuole transport, IMP, PMID:11739776.'
  - number: 15
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000007
      curie: CATH.FUNFAM:1.10.287.1060:FF:000007
      label: Charged multivesicular body protein 7
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 16
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000007
      curie: CATH.FUNFAM:1.10.287.1060:FF:000007
      label: Charged multivesicular body protein 7
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 6 Swiss-Prot and 441 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 3 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q8WUX9 (CHMP7_HUMAN) GO:0045324 late endosome to vacuole
      transport, IMP, PMID:16856878; Q86H98 (CHMP4_DICDI) GO:0008333 endosome to lysosome transport, IMP,
      PMID:15708561; Q9P7F7 (SNF7_SCHPO) GO:0043328 protein transport to vacuole involved in ubiquitin-dependent
      protein catabolic process via the multivesicular body sorting pathway, IMP, PMID:17660439.'
  - number: 17
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000007
      curie: CATH.FUNFAM:1.10.287.1060:FF:000007
      label: Charged multivesicular body protein 7
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 18
    conditions:
    - condition_type: FUNFAM
      value: 1.10.510.10:FF:000534
      curie: CATH.FUNFAM:1.10.510.10:FF:000534
      label: Serine/threonine-protein kinase PKH2
      negated: false
    - condition_type: FUNFAM
      value: 3.30.200.20:FF:000191
      curie: CATH.FUNFAM:3.30.200.20:FF:000191
      label: 3-phosphoinositide-dependent protein kinase 2-like
      negated: false
    - condition_type: TAXON
      value: '147537'
      curie: NCBITaxon:147537
      label: Saccharomycotina
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 130 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: Q03407 (PKH1_YEAST) GO:0032511 late endosome to vacuole
      transport via multivesicular body sorting pathway, IGI, PMID:22918958; Q12236 (PKH2_YEAST) GO:0032511
      late endosome to vacuole transport via multivesicular body sorting pathway, IGI, PMID:22918958.'
  - number: 19
    conditions:
    - condition_type: FUNFAM
      value: 1.20.5.110:FF:000035
      curie: CATH.FUNFAM:1.20.5.110:FF:000035
      label: Syntaxin-22 like
      negated: false
    - condition_type: FUNFAM
      value: 1.20.58.70:FF:000004
      curie: CATH.FUNFAM:1.20.58.70:FF:000004
      label: Syntaxin-22 like
      negated: false
    - condition_type: TAXON
      value: '3193'
      curie: NCBITaxon:3193
      label: Embryophyta
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 1135 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P93654 (SYP22_ARATH) GO:0045324 late endosome to vacuole
      transport, IGI, PMID:29749929; Q39233 (SYP21_ARATH) GO:0006623 protein targeting to vacuole, IDA,
      PMID:17662029.'
  - number: 20
    conditions:
    - condition_type: FUNFAM
      value: 1.20.58.160:FF:000003
      curie: CATH.FUNFAM:1.20.58.160:FF:000003
      label: VHS domain protein
      negated: false
    - condition_type: FUNFAM
      value: 1.25.40.90:FF:000008
      curie: CATH.FUNFAM:1.25.40.90:FF:000008
      label: VHS domain protein
      negated: false
    - condition_type: TAXON
      value: '4891'
      curie: NCBITaxon:4891
      label: Saccharomycetes
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 40 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P38817 (GGA2_YEAST) GO:0006896 Golgi to vacuole transport,
      IGI, PMID:10747088; Q06336 (GGA1_YEAST) GO:0006896 Golgi to vacuole transport, IGI, PMID:10747088.'
  - number: 21
    conditions:
    - condition_type: FUNFAM
      value: 2.40.160.110:FF:000001
      curie: CATH.FUNFAM:2.40.160.110:FF:000001
      label: lysosome-associated membrane glycoprotein 2 isoform X2
      negated: false
    - condition_type: FUNFAM
      value: 2.40.160.110:FF:000004
      curie: CATH.FUNFAM:2.40.160.110:FF:000004
      label: Lysosomal associated membrane protein 2
      negated: false
    - condition_type: TAXON
      value: '10066'
      curie: NCBITaxon:10066
      label: Muridae
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 13 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P17046 (LAMP2_RAT) GO:0061740 protein targeting to
      lysosome involved in chaperone-mediated autophagy, IGI, PMID:18644871; P17047 (LAMP2_MOUSE) GO:0061740
      protein targeting to lysosome involved in chaperone-mediated autophagy, IMP, PMID:27628032.'
  - number: 22
    conditions:
    - condition_type: FUNFAM
      value: 1.10.357.110:FF:000001
      curie: CATH.FUNFAM:1.10.357.110:FF:000001
      label: vacuolar protein sorting-associated protein 53 homolog
      negated: false
    - condition_type: TAXON
      value: '33208'
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 1098 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 2 with IEA only, 0 with none. Examples: Q5VIR6 (VPS53_HUMAN) GO:0007041 lysosomal transport,
      IMP, PMID:25799061; Q8CCB4 (VPS53_MOUSE) GO:0006622 protein targeting to lysosome, IMP, PMID:28658628.'
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 1.10.418.10:FF:000024
      curie: CATH.FUNFAM:1.10.418.10:FF:000024
      label: Hook homolog 3 (Drosophila)
      negated: false
    - condition_type: TAXON
      value: '376913'
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 149 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q96ED9 (HOOK2_HUMAN) GO:0008333 endosome to lysosome
      transport, IMP, PMID:18799622; Q9UJC3 (HOOK1_HUMAN) GO:0008333 endosome to lysosome transport, IMP,
      PMID:18799622.'
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1280.290:FF:000016
      curie: CATH.FUNFAM:1.20.1280.290:FF:000016
      label: Cystinosin homolog
      negated: false
    - condition_type: TAXON
      value: '1206794'
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 610 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: Q09500 (CTNS_CAEEL) GO:1904919 L-cystine transmembrane
      transport from lysosomal lumen to cytosol, IMP, PMID:22822152; Q9VCR7 (CTNS_DROME) GO:1904919 L-cystine
      transmembrane transport from lysosomal lumen to cytosol, IMP, PMID:35175796.'
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 1.20.58.80:FF:000002
      curie: CATH.FUNFAM:1.20.58.80:FF:000002
      label: Vacuolar protein sorting-associated protein 4A
      negated: false
    - condition_type: TAXON
      value: '9526'
      curie: NCBITaxon:9526
      label: Catarrhini
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 117 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: Q9UN37 (VPS4A_HUMAN) GO:0006622 protein targeting
      to lysosome, IMP, PMID:16973552; O75351 (VPS4B_HUMAN) GO:0032510 endosome to lysosome transport
      via multivesicular body sorting pathway, IMP, PMID:15024011.'
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 1.25.40.90:FF:000009
      curie: CATH.FUNFAM:1.25.40.90:FF:000009
      label: Putative signal transducing adapter molecule 1
      negated: false
    - condition_type: FUNFAM
      value: 2.30.30.40:FF:000072
      curie: CATH.FUNFAM:2.30.30.40:FF:000072
      label: Unconventional Myosin IB
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 1.25.40.90:FF:000009
      curie: CATH.FUNFAM:1.25.40.90:FF:000009
      label: Putative signal transducing adapter molecule 1
      negated: false
    - condition_type: FUNFAM
      value: 2.30.30.40:FF:000072
      curie: CATH.FUNFAM:2.30.30.40:FF:000072
      label: Unconventional Myosin IB
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 134 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: O01498 (STAM1_CAEEL) GO:0008333 endosome to lysosome
      transport, IMP, PMID:17581863; O74749 (HSE1_SCHPO) GO:0043328 protein transport to vacuole involved
      in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IMP,
      PMID:17660439.'
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 1.25.40.90:FF:000009
      curie: CATH.FUNFAM:1.25.40.90:FF:000009
      label: Putative signal transducing adapter molecule 1
      negated: false
    - condition_type: FUNFAM
      value: 2.30.30.40:FF:000072
      curie: CATH.FUNFAM:2.30.30.40:FF:000072
      label: Unconventional Myosin IB
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 2.70.130.10:FF:000008
      curie: CATH.FUNFAM:2.70.130.10:FF:000008
      label: Cation-dependent mannose-6-phosphate receptor
      negated: false
    - condition_type: TAXON
      value: '314146'
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 116 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P20645 (MPRD_HUMAN) GO:0090160 Golgi to lysosome transport,
      IDA, PMID:10799489; P24668 (MPRD_MOUSE) GO:0007041 lysosomal transport, IDA, PMID:26370502.'
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 3.30.450.50:FF:000001
      curie: CATH.FUNFAM:3.30.450.50:FF:000001
      label: AP-3 complex subunit delta-1, putative
      negated: false
    - condition_type: TAXON
      value: '7711'
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 1438 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: O14617 (AP3D1_HUMAN) GO:0140916 zinc ion import into
      lysosome, IMP, PMID:17349999; O54774 (AP3D1_MOUSE) GO:0098943 neurotransmitter receptor transport,
      postsynaptic endosome to lysosome, IDA, PMID:24217640.'
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000687
      curie: CATH.FUNFAM:3.40.50.300:FF:000687
      label: Ras-related protein RABF2b
      negated: false
    - condition_type: TAXON
      value: '71240'
      curie: NCBITaxon:71240
      label: eudicotyledons
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 951 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 2 with IEA only, 0 with none. Examples: Q9SN68 (RAF2B_ARATH) GO:0045324 late endosome to vacuole
      transport, IMP, PMID:24824487; P31582 (RAF2A_ARATH) GO:0007034 vacuolar transport, IMP, PMID:12724533.'
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000397
      curie: CATH.FUNFAM:1.10.10.10:FF:000397
      label: Vacuolar-sorting protein SNF8
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000397
      curie: CATH.FUNFAM:1.10.10.10:FF:000397
      label: Vacuolar-sorting protein SNF8
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 1382 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q12483 (SNF8_YEAST) GO:0006623 protein targeting to
      vacuole, IMP, PMID:12194858; O94663 (SNF8_SCHPO) GO:0043328 protein transport to vacuole involved
      in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, IMP,
      PMID:17660439.'
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000397
      curie: CATH.FUNFAM:1.10.10.10:FF:000397
      label: Vacuolar-sorting protein SNF8
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000012
      curie: CATH.FUNFAM:1.10.287.1060:FF:000012
      label: Vacuolar sorting protein SNF7
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000012
      curie: CATH.FUNFAM:1.10.287.1060:FF:000012
      label: Vacuolar sorting protein SNF7
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 31 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P39929 (SNF7_YEAST) GO:0045324 late endosome to vacuole
      transport, IMP, PMID:9606181; Q5ABD0 (SNF7_CANAL) GO:0006623 protein targeting to vacuole, IMP,
      PMID:18974864.'
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.1060:FF:000012
      curie: CATH.FUNFAM:1.10.287.1060:FF:000012
      label: Vacuolar sorting protein SNF7
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 1.20.5.110:FF:000060
      curie: CATH.FUNFAM:1.20.5.110:FF:000060
      label: SNARE complex subunit (Syn8)
      negated: false
    - condition_type: TAXON
      value: '2157'
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 1.20.5.110:FF:000060
      curie: CATH.FUNFAM:1.20.5.110:FF:000060
      label: SNARE complex subunit (Syn8)
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 935 TrEMBL entries match. QuickGO, GO:0007034
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P31377 (STX8_YEAST) GO:0006896 Golgi to vacuole transport,
      IMP, PMID:12453154; O14222 (FSV1_SCHPO) GO:0006896 Golgi to vacuole transport, IGI, PMID:25378562.'
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 1.20.5.110:FF:000060
      curie: CATH.FUNFAM:1.20.5.110:FF:000060
      label: SNARE complex subunit (Syn8)
      negated: false
    - condition_type: TAXON
      value: '2'
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: No UniProtKB entry matches this conjunction (UniProtKB query, November 2026), so the set annotates
      nothing.
  go_annotations:
  - go_id: GO:0007034
    go_label: vacuolar transport
    aspect: BP
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 40
review_summary: All 40 live condition sets were examined. 26 sets match Swiss-Prot entries, and in every
  one of them at least one matched entry carries GO:0007034 or a descendant with experimental evidence;
  no matched Swiss-Prot entry lacks the term. The other 14 sets (numbers 2, 4, 10, 12, 15, 17, 26, 28,
  32, 34, 35, 37, 38, 40) are Archaea or Bacteria copies of eukaryotic sets and match no UniProtKB entry,
  so they annotate nothing. The first InterPro condition, IPR005024 (Vacuolar-sorting protein SNF7-like),
  is itself mapped to GO:0007034 by InterPro2GO.
action: ACCEPT
action_rationale: Each set that matches any protein selects a family with experimentally annotated members
  in vacuolar or lysosomal transport, and the term is their common parent. The empty Archaea and Bacteria
  sets are harmless.
literature_support:
  assessment: STRONG
  notes: Curated experimental GO annotations on matched Swiss-Prot entries are listed per set in rule.condition_sets[].notes
    (QuickGO, November 2026), for example VPS10_YEAST GO:0006623 IMP PMID:8187177 (set 5), VPS4_YEAST
    GO:0045324 IMP PMID:9211789 (set 9) and SYP42_ARATH GO:0007034 IGI PMID:22307646 (set 14).
go_specificity:
  assessment: APPROPRIATE
  notes: The matched proteins are annotated to different children of GO:0007034 (for example GO:0006623
    protein targeting to vacuole, GO:0032511 late endosome to vacuole transport via multivesicular body
    sorting pathway, GO:0045324 late endosome to vacuole transport, GO:0006896 Golgi to vacuole transport),
    so GO:0007034 is the common term across the sets.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0007034
  label: vacuolar transport
  assessment: CORRECT
  correct_examples:
  - Q96FZ7
  - Q9BY43
  - Q9HD42
  - Q9NZZ3
  - Q9UQN3
  - Q9Y3E7
  - Q7LBR1
  - O43633
  - Q96CF2
  - Q8WUX9
  - Q9H444
  - P93026
  - Q56ZQ3
  - O80977
  - P40890
  - P40438
  - P32319
  - O42930
  - Q2TVY7
  - Q99176
  - P25604
  - Q02767
  - Q7Z992
  - O13872
  - P52917
  - Q5AG40
  - Q09803
  - P39940
  - Q92462
  - Q5BDP1
  - Q9SWH4
  - O65359
  - Q9SUJ1
  - Q86H98
  - Q9P7F7
  - Q03407
  - Q12236
  - P93654
  - Q39233
  - P38817
  notes: Per-set receipts are in rule.condition_sets[].notes. Accessions listed are Swiss-Prot matches
    with experimental evidence for GO:0007034 or a descendant in QuickGO (first 40).
confidence: 0.8
corrections:
- date: '2026-11-10'
  withdrawn_claim: Condition set 1 uses IPR005024 "Snare domain"; SNAREs act in many fusion events, so
    vacuolar transport is unsupported and the literature contradicts the rule.
  correction: IPR005024 is the ESCRT-III family "Vacuolar-sorting protein SNF7-like". InterPro2GO maps
    it to GO:0007034, and its primate Swiss-Prot matches are CHMP proteins.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'InterPro API: IPR005024 name "Vacuolar-sorting protein SNF7-like", type family'
  - 'rules/arba/_interpro2go.txt line 7349: InterPro:IPR005024 Snf7 family > GO:vacuolar transport ; GO:0007034'
  - 'UniProtKB query (xref:interpro-IPR005024) AND (taxonomy_id:9443) AND (reviewed:true): 19 entries,
    e.g. CHMP6_HUMAN, CHM4A_HUMAN, CHM1A_HUMAN'
- date: '2026-11-10'
  withdrawn_claim: IPR031777 is "Domain of unknown function DUF4201", and unknown-function domains should
    not be in an annotation rule.
  correction: IPR031777 is "Sortilin, C-terminal". In the live rule it occurs with IPR015943 and Fungi,
    a set whose Swiss-Prot matches include the vacuolar sorting receptor Vps10.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'InterPro API: IPR031777 name "Sortilin, C-terminal", type domain'
  - VPS10_YEAST GO:0006623 protein targeting to vacuole, IMP, PMID:8187177 (set 5)
- date: '2026-11-10'
  withdrawn_claim: The rule contains an ENTH domain set (IPR002014, IPR008942, Fungi) and a Sec1-like
    set (IPR006581, IPR031777, Dikarya).
  correction: IPR002014 is "VHS domain" and IPR006581 is "VPS10". Neither set is in the live rule.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'InterPro API: IPR002014 name "VHS domain"; IPR006581 name "VPS10"'
  - 'rest.uniprot.org/arba/ARBA00026698 retrieved 2026-11-09: 40 condition sets, none containing IPR002014
    or IPR006581'
- date: '2026-11-10'
  withdrawn_claim: The rule has 26 condition sets, which exceeds a manageable threshold of 12 and is a
    reason to deprecate.
  correction: The number of alternative sets says nothing about whether each is right. All 40 live sets
    were checked individually.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - Per-set Swiss-Prot counts and evidence in rule.condition_sets[].notes
- date: '2026-11-10'
  withdrawn_claim: Taxonomic scope is chaotic (Primates to Eukaryota), showing a lack of biological coherence.
  correction: Each taxon is a conjunct that narrows one signature. The Archaea and Bacteria copies match
    no protein.
  error_type: TAXON_MISREAD
  evidence:
  - 'Sets 2, 4, 10, 12, 15, 17, 26, 28, 32, 34, 35, 37, 38, 40: 0 Swiss-Prot and 0 TrEMBL matches (UniProtKB
    query, November 2026)'
- date: '2026-11-10'
  withdrawn_claim: GO:0098884 is "endocytic activity", a molecular function alternative.
  correction: GO:0098884 is the biological process postsynaptic neurotransmitter receptor internalization.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'QuickGO: GO:0098884 postsynaptic neurotransmitter receptor internalization, aspect biological_process'