ARBA00026991 energy derivation by oxidation of organic compounds (GO:0015980)

View original ARBA rule on UniProt

Type: ARBA
Status: COMPLETE
Action: MODIFY
Confidence: 0.60

Description

Assigns GO:0015980 (energy derivation by oxidation of organic compounds) through 69 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover enzymes of glycolysis, the tricarboxylic acid cycle, respiratory electron transport and glycogen metabolism.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
69
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00026991 and re-render to add it.

Review Summary

All 69 live condition sets were checked against Swiss-Prot. In all but one, every reviewed match carries GO:0015980 or a descendant. Set 29 (pyruvate:ferredoxin oxidoreductase FunFams) has 9 reviewed matches of which 4 carry the term; the other 5 are annotated to electron transport chain only. One set is too wide as written: set 1 requires only the thiamin diphosphate-binding fold in Thermoproteota, a condition met by 51 unreviewed acetolactate synthases, which are biosynthetic enzymes.

Action Rationale

Glycolysis, the tricarboxylic acid cycle, oxidative phosphorylation and glycogen metabolism are all descendants of the rule term, so one rule for them is coherent. The defect found is the breadth of set 1. The counts are from Swiss-Prot, which is also what ARBA learns its rules from, so they show the condition sets are coherent rather than giving an independent error rate for unreviewed entries.

GO Annotations

GO:0015980 - energy derivation by oxidation of organic compounds
Aspect: BP

Annotation Assessments

UNDECIDED GO_TERM GO:0015980 - energy derivation by oxidation of organic compounds
Matched proteins: ; incorrect:
Discriminating features: Set 1 matches by fold alone; the reviewed matches are all 2-oxoacid:ferredoxin oxidoreductase subunits, while the acetolactate synthases that meet the same conditions are unreviewed.
Correct examples: Q96Y66, P72578

UniProtKB release 2026_04: set 1 (IPR029061 AND taxon Thermoproteota) matches 12 reviewed entries, all subunits of 2-oxoacid:ferredoxin oxidoreductase such as Q96Y66 and P72578, and 925 unreviewed entries. 51 of the unreviewed entries have EC 2.2.1.6, for example A0A2U9INF1 and G7VDF4, named Acetolactate synthase by RuleBase RU003591 and annotated to GO:0009099. The UniProtKB record of A0A2U9INF1 did not list GO:0015980 when retrieved on 2026-11-10, so the breadth is a property of the condition set as published; whether the annotation is emitted for these entries was not established.

Rule Definition

Condition Sets

Condition Set 1

2 condition(s)
Notes:

UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0015980 or a descendant, 12 of those by a manual-evidence GO annotation. 925 unreviewed entries match. The reviewed matches are 2-oxoacid:ferredoxin oxidoreductase subunits, but 51 of the unreviewed matches are acetolactate synthases (EC 2.2.1.6), for example A0A2U9INF1. This set is too wide.

Condition Set 2

2 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or a descendant, 10 of those by a manual-evidence GO annotation. 2101 unreviewed entries match.

Condition Set 3

2 condition(s)
Notes:

UniProtKB release 2026_04: 13 reviewed entries match this set; 13 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 11934 unreviewed entries match.

Condition Set 4

3 condition(s)
Notes:

UniProtKB release 2026_04: 17 reviewed entries match this set; 17 of them carry GO:0015980 or a descendant, 11 of those by a manual-evidence GO annotation. 10193 unreviewed entries match.

Condition Set 5

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or a descendant, 10 of those by a manual-evidence GO annotation. 894 unreviewed entries match.

Condition Set 6

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 3668 unreviewed entries match.

Condition Set 7

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 128 unreviewed entries match.

Condition Set 8

2 condition(s)
Notes:

UniProtKB release 2026_04: 55 reviewed entries match this set; 55 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 1037 unreviewed entries match.

Condition Set 9

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 2100 unreviewed entries match.

Condition Set 10

3 condition(s)
Notes:

UniProtKB release 2026_04: 54 reviewed entries match this set; 54 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 1050 unreviewed entries match.

Condition Set 11

3 condition(s)
Notes:

UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0015980 or a descendant, 20 of those by a manual-evidence GO annotation. 3369 unreviewed entries match.

Condition Set 12

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or a descendant, 10 of those by a manual-evidence GO annotation. 1465 unreviewed entries match.

Condition Set 13

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or a descendant, 10 of those by a manual-evidence GO annotation. 754 unreviewed entries match.

Condition Set 14

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 81 unreviewed entries match.

Condition Set 15

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 129 unreviewed entries match.

Condition Set 16

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 48 unreviewed entries match.

Condition Set 17

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 972 unreviewed entries match.

Condition Set 18

2 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 1424 unreviewed entries match.

Condition Set 19

1 condition(s)
Notes:

UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 2663 unreviewed entries match.

Condition Set 20

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 193 unreviewed entries match.

Condition Set 21

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 247 unreviewed entries match.

Condition Set 22

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 226 unreviewed entries match.

Condition Set 23

3 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 984 unreviewed entries match.

Condition Set 24

3 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 1041 unreviewed entries match.

Condition Set 25

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 328 unreviewed entries match.

Condition Set 26

3 condition(s)
Notes:

UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0015980 or a descendant, 7 of those by a manual-evidence GO annotation. 1211 unreviewed entries match.

Condition Set 27

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 178 unreviewed entries match.

Condition Set 28

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 33 unreviewed entries match.

Condition Set 29

3 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 2582 unreviewed entries match. The five reviewed matches without the term, for example P94692 and P03833, are annotated to GO:0022900. This is missing annotation on those entries, not evidence against the set.

Condition Set 30

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 21 unreviewed entries match.

Condition Set 31

3 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 13 unreviewed entries match.

Condition Set 32

2 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 387 unreviewed entries match.

Condition Set 33

2 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 135 unreviewed entries match.

Condition Set 34

1 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 1504 unreviewed entries match.

Condition Set 35

1 condition(s)
Notes:

UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0015980 or a descendant, 8 of those by a manual-evidence GO annotation. 4253 unreviewed entries match.

Condition Set 36

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 142 unreviewed entries match.

Condition Set 37

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 1044 unreviewed entries match.

Condition Set 38

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 961 unreviewed entries match.

Condition Set 39

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.

Condition Set 40

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 133 unreviewed entries match.

Condition Set 41

3 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 731 unreviewed entries match.

Condition Set 42

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 962 unreviewed entries match.

Condition Set 43

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 663 unreviewed entries match.

Condition Set 44

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 989 unreviewed entries match.

Condition Set 45

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 1 of those by a manual-evidence GO annotation. 6 unreviewed entries match.

Condition Set 46

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 176 unreviewed entries match.

Condition Set 47

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 121 unreviewed entries match.

Condition Set 48

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 73 unreviewed entries match.

Condition Set 49

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 93 unreviewed entries match.

Condition Set 50

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 8 unreviewed entries match.

Condition Set 51

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 100 unreviewed entries match.

Condition Set 52

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 508 unreviewed entries match.

Condition Set 53

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 6 unreviewed entries match.

Condition Set 54

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 348 unreviewed entries match.

Condition Set 55

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 24 unreviewed entries match.

Condition Set 56

2 condition(s)
Notes:

UniProtKB release 2026_04: 640 reviewed entries match this set; 640 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 3680 unreviewed entries match.

Condition Set 57

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 136 unreviewed entries match.

Condition Set 58

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 290 unreviewed entries match.

Condition Set 59

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 422 unreviewed entries match.

Condition Set 60

2 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or a descendant, 5 of those by a manual-evidence GO annotation. 28 unreviewed entries match.

Condition Set 61

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 22 unreviewed entries match.

Condition Set 62

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 14 unreviewed entries match.

Condition Set 63

1 condition(s)
Notes:

UniProtKB release 2026_04: 110 reviewed entries match this set; 110 of them carry GO:0015980 or a descendant, 6 of those by a manual-evidence GO annotation. 1365 unreviewed entries match.

Condition Set 64

1 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 443 unreviewed entries match.

Condition Set 65

1 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or a descendant, 3 of those by a manual-evidence GO annotation. 2480 unreviewed entries match.

Condition Set 66

1 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0015980 or a descendant, 4 of those by a manual-evidence GO annotation. 734 unreviewed entries match.

Condition Set 67

1 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 15 unreviewed entries match.

Condition Set 68

1 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 3035 unreviewed entries match.

Condition Set 69

1 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or a descendant, 2 of those by a manual-evidence GO annotation. 54 unreviewed entries match.

Assessments

APPROPRIATE

GO:0006096, GO:0006099, GO:0006119, GO:0022904 and GO:0005977 each have GO:0015980 among their is_a or part_of ancestors (QuickGO), so the rule term is the shared parent of the pathways the sets cover.

Raw YAML

View Source YAML 
id: ARBA00026991
description: >-
  Assigns GO:0015980 (energy derivation by oxidation of organic compounds) through 69 alternative
  condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon.
  The sets cover enzymes of glycolysis, the tricarboxylic acid cycle, respiratory electron transport
  and glycogen metabolism.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00026991
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR029061
      curie: InterPro:IPR029061
      label: Thiamin diphosphate-binding fold
      negated: false
    - condition_type: TAXON
      value: Thermoproteota
      curie: NCBITaxon:28889
      label: Thermoproteota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0015980 or
      a descendant, 12 of those by a manual-evidence GO annotation. 925 unreviewed entries match.
      The reviewed matches are 2-oxoacid:ferredoxin oxidoreductase subunits, but 51 of the unreviewed
      matches are acetolactate synthases (EC 2.2.1.6), for example A0A2U9INF1. This set is too wide.
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR008631
      curie: InterPro:IPR008631
      label: Glycogen synthase
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or
      a descendant, 10 of those by a manual-evidence GO annotation. 2101 unreviewed entries match.
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR011766
      curie: InterPro:IPR011766
      label: Thiamine pyrophosphate enzyme, TPP-binding
      negated: false
    - condition_type: INTERPRO
      value: IPR051457
      curie: InterPro:IPR051457
      label: 2-oxoacid:ferredoxin oxidoreductase
      negated: false
    notes: >-
      UniProtKB release 2026_04: 13 reviewed entries match this set; 13 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 11934 unreviewed entries match.
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR000811
      curie: InterPro:IPR000811
      label: Glycosyl transferase, family 35
      negated: false
    - condition_type: INTERPRO
      value: IPR011833
      curie: InterPro:IPR011833
      label: Glycogen/starch/alpha-glucan phosphorylase
      negated: false
    - condition_type: PANTHER
      value: PTHR11468:SF3
      curie: PANTHER:PTHR11468:SF3
      label: GLYCOGEN PHOSPHORYLASE, LIVER FORM
      negated: false
    notes: >-
      UniProtKB release 2026_04: 17 reviewed entries match this set; 17 of them carry GO:0015980 or
      a descendant, 11 of those by a manual-evidence GO annotation. 10193 unreviewed entries match.
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR001697
      curie: InterPro:IPR001697
      label: Pyruvate kinase
      negated: false
    - condition_type: INTERPRO
      value: IPR011037
      curie: InterPro:IPR011037
      label: Pyruvate kinase-like, insert domain superfamily
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or
      a descendant, 10 of those by a manual-evidence GO annotation. 894 unreviewed entries match.
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR002495
      curie: InterPro:IPR002495
      label: Glycosyl transferase, family 8
      negated: false
    - condition_type: INTERPRO
      value: IPR050587
      curie: InterPro:IPR050587
      label: GNT1/Glycosyltransferase 8
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or
      a descendant, 6 of those by a manual-evidence GO annotation. 3668 unreviewed entries match.
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR035090
      curie: InterPro:IPR035090
      label: Phosphorylase pyridoxal-phosphate attachment site
      negated: false
    - condition_type: TAXON
      value: Rodentia
      curie: NCBITaxon:9989
      label: Rodentia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or
      a descendant, 6 of those by a manual-evidence GO annotation. 128 unreviewed entries match.
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR036280
      curie: InterPro:IPR036280
      label: Multiheme cytochrome superfamily
      negated: false
    - condition_type: TAXON
      value: Enterobacterales
      curie: NCBITaxon:91347
      label: Enterobacterales
      negated: false
    notes: >-
      UniProtKB release 2026_04: 55 reviewed entries match this set; 55 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 1037 unreviewed entries match.
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR000089
      curie: InterPro:IPR000089
      label: Biotin/lipoyl attachment
      negated: false
    - condition_type: INTERPRO
      value: IPR045257
      curie: InterPro:IPR045257
      label: Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 2100 unreviewed entries match.
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR006657
      curie: InterPro:IPR006657
      label: Molybdopterin dinucleotide-binding domain
      negated: false
    - condition_type: PANTHER
      value: PTHR43105
      curie: PANTHER:PTHR43105
      label: RESPIRATORY NITRATE REDUCTASE
      negated: false
    - condition_type: TAXON
      value: Enterobacteriaceae
      curie: NCBITaxon:543
      label: Enterobacteriaceae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 54 reviewed entries match this set; 54 of them carry GO:0015980 or
      a descendant, 5 of those by a manual-evidence GO annotation. 1050 unreviewed entries match.
  - number: 11
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.450:FF:000043
      curie: CATH.FunFam:3.40.50.450:FF:000043
      label: ATP-dependent 6-phosphofructokinase, platelet type
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.460:FF:000001
      curie: CATH.FunFam:3.40.50.460:FF:000001
      label: ATP-dependent 6-phosphofructokinase
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0015980 or
      a descendant, 20 of those by a manual-evidence GO annotation. 3369 unreviewed entries match.
  - number: 12
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000014
      curie: CATH.FunFam:3.40.50.2000:FF:000014
      label: Glycogen [starch] synthase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000028
      curie: CATH.FunFam:3.40.50.2000:FF:000028
      label: Glycogen [starch] synthase
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or
      a descendant, 10 of those by a manual-evidence GO annotation. 1465 unreviewed entries match.
  - number: 13
    conditions:
    - condition_type: FUNFAM
      value: 3.20.20.60:FF:000025
      curie: CATH.FunFam:3.20.20.60:FF:000025
      label: Pyruvate kinase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1380.20:FF:000001
      curie: CATH.FunFam:3.40.1380.20:FF:000001
      label: Pyruvate kinase
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or
      a descendant, 10 of those by a manual-evidence GO annotation. 754 unreviewed entries match.
  - number: 14
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.920:FF:000009
      curie: CATH.FunFam:3.40.50.920:FF:000009
      label: 2-oxoglutarate ferredoxin oxidoreductase subunit alpha
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000022
      curie: CATH.FunFam:3.40.50.970:FF:000022
      label: 2-oxoglutarate ferredoxin oxidoreductase alpha subunit
      negated: false
    - condition_type: TAXON
      value: Archaea
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or
      a descendant, 6 of those by a manual-evidence GO annotation. 81 unreviewed entries match.
  - number: 15
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000005
      curie: CATH.FunFam:3.40.50.2000:FF:000005
      label: Alpha-1,4 glucan phosphorylase
      negated: false
    - condition_type: TAXON
      value: Rodentia
      curie: NCBITaxon:9989
      label: Rodentia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or
      a descendant, 6 of those by a manual-evidence GO annotation. 129 unreviewed entries match.
  - number: 16
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000049
      curie: CATH.FunFam:3.40.50.970:FF:000049
      label: 2-oxoglutarate ferredoxin oxidoreductase subunit beta
      negated: false
    - condition_type: TAXON
      value: Thermoproteota
      curie: NCBITaxon:28889
      label: Thermoproteota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or
      a descendant, 6 of those by a manual-evidence GO annotation. 48 unreviewed entries match.
  - number: 17
    conditions:
    - condition_type: FUNFAM
      value: 2.40.50.100:FF:000010
      curie: CATH.FunFam:2.40.50.100:FF:000010
      label: Acetyltransferase component of pyruvate dehydrogenase complex
      negated: false
    - condition_type: FUNFAM
      value: 3.30.559.10:FF:000003
      curie: CATH.FunFam:3.30.559.10:FF:000003
      label: Acetyltransferase component of pyruvate dehydrogenase complex
      negated: false
    - condition_type: FUNFAM
      value: 4.10.320.10:FF:000005
      curie: CATH.FunFam:4.10.320.10:FF:000005
      label: Acetyltransferase component of pyruvate dehydrogenase complex
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0015980 or
      a descendant, 6 of those by a manual-evidence GO annotation. 972 unreviewed entries match.
  - number: 18
    conditions:
    - condition_type: FUNFAM
      value: 3.90.550.10:FF:000025
      curie: CATH.FunFam:3.90.550.10:FF:000025
      label: Glycogenin-1 isoform 1
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 5 of those by a manual-evidence GO annotation. 1424 unreviewed entries match.
  - number: 19
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.460:FF:000008
      curie: CATH.FunFam:3.40.50.460:FF:000008
      label: ATP-dependent 6-phosphofructokinase
      negated: false
    notes: >-
      UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 2663 unreviewed entries match.
  - number: 20
    conditions:
    - condition_type: FUNFAM
      value: 1.10.1060.10:FF:000029
      curie: CATH.FunFam:1.10.1060.10:FF:000029
      label: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
      negated: false
    - condition_type: FUNFAM
      value: 3.10.20.30:FF:000007
      curie: CATH.FunFam:3.10.20.30:FF:000007
      label: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Eutheria
      curie: NCBITaxon:9347
      label: Eutheria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 5 of those by a manual-evidence GO annotation. 193 unreviewed entries match.
  - number: 21
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1260:FF:000019
      curie: CATH.FunFam:3.40.50.1260:FF:000019
      label: Phosphoglycerate kinase 1
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1260:FF:000031
      curie: CATH.FunFam:3.40.50.1260:FF:000031
      label: Phosphoglycerate kinase 1
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 247 unreviewed entries match.
  - number: 22
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.100:FF:000007
      curie: CATH.FunFam:3.50.50.100:FF:000007
      label: Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 226 unreviewed entries match.
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.1590:FF:000001
      curie: CATH.FunFam:1.10.10.1590:FF:000001
      label: NADH-quinone oxidoreductase subunit E
      negated: false
    - condition_type: FUNFAM
      value: 3.40.30.10:FF:000022
      curie: CATH.FunFam:3.40.30.10:FF:000022
      label: NADH dehydrogenase flavoprotein 2, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 984 unreviewed entries match.
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1440.230:FF:000001
      curie: CATH.FunFam:1.20.1440.230:FF:000001
      label: Mitochondrial NADH dehydrogenase flavoprotein 1
      negated: false
    - condition_type: FUNFAM
      value: 3.10.20.600:FF:000001
      curie: CATH.FunFam:3.10.20.600:FF:000001
      label: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 1041 unreviewed entries match.
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.1180:FF:000001
      curie: CATH.FunFam:2.60.40.1180:FF:000001
      label: Maltase-glucoamylase, intestinal
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1180:FF:000005
      curie: CATH.FunFam:2.60.40.1180:FF:000005
      label: Maltase-glucoamylase, intestinal
      negated: false
    - condition_type: FUNFAM
      value: 3.20.20.80:FF:000072
      curie: CATH.FunFam:3.20.20.80:FF:000072
      label: lysosomal alpha-glucosidase isoform X2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 5 of those by a manual-evidence GO annotation. 328 unreviewed entries match.
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.1180:FF:000003
      curie: CATH.FunFam:2.60.40.1180:FF:000003
      label: 1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic
      negated: false
    - condition_type: FUNFAM
      value: 3.20.20.80:FF:000001
      curie: CATH.FunFam:3.20.20.80:FF:000001
      label: 1,4-alpha-glucan branching enzyme
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: >-
      UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0015980 or
      a descendant, 7 of those by a manual-evidence GO annotation. 1211 unreviewed entries match.
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 3.20.20.120:FF:000002
      curie: CATH.FunFam:3.20.20.120:FF:000002
      label: Enolase 1
      negated: false
    - condition_type: FUNFAM
      value: 3.30.390.10:FF:000001
      curie: CATH.FunFam:3.30.390.10:FF:000001
      label: Enolase
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 5 of those by a manual-evidence GO annotation. 178 unreviewed entries match.
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 3.30.360.10:FF:000001
      curie: CATH.FunFam:3.30.360.10:FF:000001
      label: Glyceraldehyde-3-phosphate dehydrogenase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000001
      curie: CATH.FunFam:3.40.50.720:FF:000001
      label: Glyceraldehyde-3-phosphate dehydrogenase
      negated: false
    - condition_type: TAXON
      value: Saccharomyces
      curie: NCBITaxon:4930
      label: Saccharomyces
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 33 unreviewed entries match.
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.20:FF:000022
      curie: CATH.FunFam:3.30.70.20:FF:000022
      label: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.920:FF:000007
      curie: CATH.FunFam:3.40.50.920:FF:000007
      label: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000041
      curie: CATH.FunFam:3.40.50.970:FF:000041
      label: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 2582 unreviewed entries match.
      The five reviewed matches without the term, for example P94692 and P03833, are annotated to
      GO:0022900. This is missing annotation on those entries, not evidence against the set.
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000029
      curie: CATH.FunFam:3.40.50.720:FF:000029
      label: L-lactate dehydrogenase A chain
      negated: false
    - condition_type: FUNFAM
      value: 3.90.110.10:FF:000003
      curie: CATH.FunFam:3.90.110.10:FF:000003
      label: L-lactate dehydrogenase A chain
      negated: false
    - condition_type: TAXON
      value: Mus
      curie: NCBITaxon:10088
      label: Mus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 21 unreviewed entries match.
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000019
      curie: CATH.FunFam:3.40.50.970:FF:000019
      label: Pyruvate decarboxylase isozyme
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000024
      curie: CATH.FunFam:3.40.50.970:FF:000024
      label: Pyruvate decarboxylase isozyme
      negated: false
    - condition_type: TAXON
      value: Taphrinomycotina
      curie: NCBITaxon:451866
      label: Taphrinomycotina
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 13 unreviewed entries match.
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3820.10:FF:000001
      curie: CATH.FunFam:1.10.3820.10:FF:000001
      label: Cytochrome c-type protein
      negated: false
    - condition_type: TAXON
      value: Enterobacterales
      curie: NCBITaxon:91347
      label: Enterobacterales
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 387 unreviewed entries match.
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1240:FF:000007
      curie: CATH.FunFam:3.40.50.1240:FF:000007
      label: Phosphoglycerate mutase
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 135 unreviewed entries match.
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000045
      curie: CATH.FunFam:3.40.50.2000:FF:000045
      label: Glycogen [starch] synthase
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 1504 unreviewed entries match.
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 3.40.718.10:FF:000001
      curie: CATH.FunFam:3.40.718.10:FF:000001
      label: Isocitrate dehydrogenase [NAD] subunit, mitochondrial
      negated: false
    notes: >-
      UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0015980 or
      a descendant, 8 of those by a manual-evidence GO annotation. 4253 unreviewed entries match.
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 1.10.1390.10:FF:000002
      curie: CATH.FunFam:1.10.1390.10:FF:000002
      label: Glucose-6-phosphate isomerase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.10490:FF:000018
      curie: CATH.FunFam:3.40.50.10490:FF:000018
      label: Glucose-6-phosphate isomerase
      negated: false
    - condition_type: TAXON
      value: Liliopsida
      curie: NCBITaxon:4447
      label: Liliopsida
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 142 unreviewed entries match.
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 1.10.275.10:FF:000001
      curie: CATH.FunFam:1.10.275.10:FF:000001
      label: Fumarate hydratase, mitochondrial
      negated: false
    - condition_type: FUNFAM
      value: 1.10.40.30:FF:000002
      curie: CATH.FunFam:1.10.40.30:FF:000002
      label: Fumarate hydratase class II
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1044 unreviewed entries match.
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3650.10:FF:000001
      curie: CATH.FunFam:1.10.3650.10:FF:000001
      label: Respiratory nitrate reductase subunit beta
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.20:FF:000005
      curie: CATH.FunFam:3.30.70.20:FF:000005
      label: Respiratory nitrate reductase beta subunit
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.20:FF:000008
      curie: CATH.FunFam:3.30.70.20:FF:000008
      label: Respiratory nitrate reductase beta subunit
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 961 unreviewed entries match.
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 1.10.510.10:FF:000149
      curie: CATH.FunFam:1.10.510.10:FF:000149
      label: phosphorylase b kinase gamma catalytic chain, liver/testis isoform
      negated: false
    - condition_type: FUNFAM
      value: 3.30.200.20:FF:000138
      curie: CATH.FunFam:3.30.200.20:FF:000138
      label: Phosphorylase b kinase gamma catalytic chain, liver/testis
      negated: false
    - condition_type: TAXON
      value: Rattus
      curie: NCBITaxon:10114
      label: Rattus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 1.20.58.100:FF:000001
      curie: CATH.FunFam:1.20.58.100:FF:000001
      label: Succinate dehydrogenase flavoprotein subunit (SdhA)
      negated: false
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000026
      curie: CATH.FunFam:3.50.50.60:FF:000026
      label: Succinate dehydrogenase flavoprotein subunit
      negated: false
    - condition_type: TAXON
      value: Saccharomycotina
      curie: NCBITaxon:147537
      label: Saccharomycotina
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 133 unreviewed entries match.
  - number: 41
    conditions:
    - condition_type: FUNFAM
      value: 2.40.33.10:FF:000001
      curie: CATH.FunFam:2.40.33.10:FF:000001
      label: Pyruvate kinase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1380.20:FF:000003
      curie: CATH.FunFam:3.40.1380.20:FF:000003
      label: Pyruvate kinase
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 731 unreviewed entries match.
  - number: 42
    conditions:
    - condition_type: FUNFAM
      value: 2.40.33.10:FF:000002
      curie: CATH.FunFam:2.40.33.10:FF:000002
      label: Pyruvate kinase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1380.20:FF:000004
      curie: CATH.FunFam:3.40.1380.20:FF:000004
      label: Pyruvate kinase
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 962 unreviewed entries match.
  - number: 43
    conditions:
    - condition_type: FUNFAM
      value: 2.40.33.10:FF:000003
      curie: CATH.FunFam:2.40.33.10:FF:000003
      label: Pyruvate kinase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1380.20:FF:000008
      curie: CATH.FunFam:3.40.1380.20:FF:000008
      label: Pyruvate kinase
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 663 unreviewed entries match.
  - number: 44
    conditions:
    - condition_type: FUNFAM
      value: 2.40.40.20:FF:000017
      curie: CATH.FunFam:2.40.40.20:FF:000017
      label: Formate dehydrogenase, alpha subunit
      negated: false
    - condition_type: FUNFAM
      value: 3.30.200.210:FF:000003
      curie: CATH.FunFam:3.30.200.210:FF:000003
      label: Formate dehydrogenase-N subunit alpha
      negated: false
    - condition_type: FUNFAM
      value: 3.40.228.10:FF:000006
      curie: CATH.FunFam:3.40.228.10:FF:000006
      label: Formate dehydrogenase, alpha subunit, selenocysteine-containing
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 989 unreviewed entries match.
  - number: 45
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.1180:FF:000054
      curie: CATH.FunFam:2.60.40.1180:FF:000054
      label: Trehalose synthase/amylase TreS
      negated: false
    - condition_type: FUNFAM
      value: 3.20.20.80:FF:000055
      curie: CATH.FunFam:3.20.20.80:FF:000055
      label: Trehalose synthase
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 1 of those by a manual-evidence GO annotation. 6 unreviewed entries match.
  - number: 46
    conditions:
    - condition_type: FUNFAM
      value: 3.20.19.10:FF:000001
      curie: CATH.FunFam:3.20.19.10:FF:000001
      label: Aconitate hydratase
      negated: false
    - condition_type: FUNFAM
      value: 3.30.499.10:FF:000002
      curie: CATH.FunFam:3.30.499.10:FF:000002
      label: Aconitate hydratase
      negated: false
    - condition_type: TAXON
      value: Enterobacteriaceae
      curie: NCBITaxon:543
      label: Enterobacteriaceae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 176 unreviewed entries match.
  - number: 47
    conditions:
    - condition_type: FUNFAM
      value: 3.20.19.10:FF:000002
      curie: CATH.FunFam:3.20.19.10:FF:000002
      label: Aconitate hydratase, mitochondrial
      negated: false
    - condition_type: FUNFAM
      value: 3.30.499.10:FF:000003
      curie: CATH.FunFam:3.30.499.10:FF:000003
      label: Aconitate hydratase, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Saccharomycetes
      curie: NCBITaxon:4891
      label: Saccharomycetes
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 121 unreviewed entries match.
  - number: 48
    conditions:
    - condition_type: FUNFAM
      value: 3.30.310.50:FF:000002
      curie: CATH.FunFam:3.30.310.50:FF:000002
      label: Phosphoglucomutase 5
      negated: false
    - condition_type: FUNFAM
      value: 3.40.120.10:FF:000004
      curie: CATH.FunFam:3.40.120.10:FF:000004
      label: Phosphoglucomutase 5
      negated: false
    - condition_type: TAXON
      value: Saccharomycetales
      curie: NCBITaxon:4892
      label: Saccharomycetales
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 73 unreviewed entries match.
  - number: 49
    conditions:
    - condition_type: FUNFAM
      value: 3.30.360.10:FF:000044
      curie: CATH.FunFam:3.30.360.10:FF:000044
      label: Uncharacterized protein
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000636
      curie: CATH.FunFam:3.40.50.720:FF:000636
      label: Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:001161
      curie: CATH.FunFam:3.40.50.720:FF:001161
      label: Glyceraldehyde-3-phosphate dehydrogenase
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 93 unreviewed entries match.
  - number: 50
    conditions:
    - condition_type: FUNFAM
      value: 3.30.390.30:FF:000001
      curie: CATH.FunFam:3.30.390.30:FF:000001
      label: Dihydrolipoyl dehydrogenase
      negated: false
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000025
      curie: CATH.FunFam:3.50.50.60:FF:000025
      label: Dihydrolipoyl dehydrogenase
      negated: false
    - condition_type: TAXON
      value: Muridae
      curie: NCBITaxon:10066
      label: Muridae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 8 unreviewed entries match.
  - number: 51
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.10490:FF:000001
      curie: CATH.FunFam:3.40.50.10490:FF:000001
      label: Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.10490:FF:000126
      curie: CATH.FunFam:3.40.50.10490:FF:000126
      label: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
      negated: false
    - condition_type: TAXON
      value: Catarrhini
      curie: NCBITaxon:9526
      label: Catarrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 100 unreviewed entries match.
  - number: 52
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.12440:FF:000001
      curie: CATH.FunFam:3.40.50.12440:FF:000001
      label: Nitrate reductase subunit alpha
      negated: false
    - condition_type: FUNFAM
      value: 4.10.1200.10:FF:000001
      curie: CATH.FunFam:4.10.1200.10:FF:000001
      label: Respiratory nitrate reductase subunit alpha
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 508 unreviewed entries match.
  - number: 53
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.261:FF:000005
      curie: CATH.FunFam:3.40.50.261:FF:000005
      label: Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000002
      curie: CATH.FunFam:3.40.50.720:FF:000002
      label: Succinate--CoA ligase [ADP-forming] subunit alpha
      negated: false
    - condition_type: TAXON
      value: Murinae
      curie: NCBITaxon:39107
      label: Murinae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 6 unreviewed entries match.
  - number: 54
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1300.10:FF:000011
      curie: CATH.FunFam:1.20.1300.10:FF:000011
      label: Succinate dehydrogenase cytochrome b560 subunit
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 348 unreviewed entries match.
  - number: 55
    conditions:
    - condition_type: FUNFAM
      value: 1.20.5.480:FF:000001
      curie: CATH.FunFam:1.20.5.480:FF:000001
      label: Formate dehydrogenase iron-sulfur subunit
      negated: false
    - condition_type: TAXON
      value: Escherichia
      curie: NCBITaxon:561
      label: Escherichia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 24 unreviewed entries match.
  - number: 56
    conditions:
    - condition_type: FUNFAM
      value: 1.20.810.10:FF:000002
      curie: CATH.FunFam:1.20.810.10:FF:000002
      label: Cytochrome b
      negated: false
    - condition_type: TAXON
      value: Laurasiatheria
      curie: NCBITaxon:314145
      label: Laurasiatheria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 640 reviewed entries match this set; 640 of them carry GO:0015980
      or a descendant, 5 of those by a manual-evidence GO annotation. 3680 unreviewed entries match.
  - number: 57
    conditions:
    - condition_type: FUNFAM
      value: 2.120.10.30:FF:000059
      curie: CATH.FunFam:2.120.10.30:FF:000059
      label: E3 ubiquitin-protein ligase NHLRC1
      negated: false
    - condition_type: FUNFAM
      value: 3.30.40.10:FF:000372
      curie: CATH.FunFam:3.30.40.10:FF:000372
      label: E3 ubiquitin-protein ligase NHLRC1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 136 unreviewed entries match.
  - number: 58
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.10:FF:000550
      curie: CATH.FunFam:2.60.40.10:FF:000550
      label: 1,4-alpha-glucan-branching enzyme isoform B
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1180:FF:000014
      curie: CATH.FunFam:2.60.40.1180:FF:000014
      label: 1,4-alpha-glucan-branching enzyme
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 290 unreviewed entries match.
  - number: 59
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.10:FF:001039
      curie: CATH.FunFam:2.60.40.10:FF:001039
      label: laforin isoform X1
      negated: false
    - condition_type: FUNFAM
      value: 3.90.190.10:FF:000054
      curie: CATH.FunFam:3.90.190.10:FF:000054
      label: laforin isoform X1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 422 unreviewed entries match.
  - number: 60
    conditions:
    - condition_type: FUNFAM
      value: 3.20.20.70:FF:000021
      curie: CATH.FunFam:3.20.20.70:FF:000021
      label: Fructose-bisphosphate aldolase
      negated: false
    - condition_type: TAXON
      value: Hominidae
      curie: NCBITaxon:9604
      label: Hominidae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0015980 or
      a descendant, 5 of those by a manual-evidence GO annotation. 28 unreviewed entries match.
  - number: 61
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000002
      curie: CATH.FunFam:3.40.50.2000:FF:000002
      label: Alpha-1,4 glucan phosphorylase
      negated: false
    - condition_type: TAXON
      value: Amoebozoa
      curie: NCBITaxon:554915
      label: Amoebozoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 22 unreviewed entries match.
  - number: 62
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000020
      curie: CATH.FunFam:3.40.50.970:FF:000020
      label: Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
      negated: false
    - condition_type: TAXON
      value: Homo
      curie: NCBITaxon:9605
      label: Homo
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 14 unreviewed entries match.
  - number: 63
    conditions:
    - condition_type: FUNFAM
      value: 1.10.645.10:FF:000001
      curie: CATH.FunFam:1.10.645.10:FF:000001
      label: NADH-quinone oxidoreductase subunit C/D
      negated: false
    notes: >-
      UniProtKB release 2026_04: 110 reviewed entries match this set; 110 of them carry GO:0015980
      or a descendant, 6 of those by a manual-evidence GO annotation. 1365 unreviewed entries match.
  - number: 64
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1300.10:FF:000008
      curie: CATH.FunFam:1.20.1300.10:FF:000008
      label: Succinate dehydrogenase cytochrome b560 subunit
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 443 unreviewed entries match.
  - number: 65
    conditions:
    - condition_type: FUNFAM
      value: 1.20.950.20:FF:000002
      curie: CATH.FunFam:1.20.950.20:FF:000002
      label: Formate dehydrogenase cytochrome b556 subunit
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0015980 or
      a descendant, 3 of those by a manual-evidence GO annotation. 2480 unreviewed entries match.
  - number: 66
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.20:FF:000003
      curie: CATH.FunFam:3.30.70.20:FF:000003
      label: Dimethyl sulfoxide reductase subunit B
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0015980 or
      a descendant, 4 of those by a manual-evidence GO annotation. 734 unreviewed entries match.
  - number: 67
    conditions:
    - condition_type: FUNFAM
      value: 3.40.1000.40:FF:000001
      curie: CATH.FunFam:3.40.1000.40:FF:000001
      label: Respiratory growth induced protein 2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 15 unreviewed entries match.
  - number: 68
    conditions:
    - condition_type: FUNFAM
      value: 3.90.550.10:FF:000092
      curie: CATH.FunFam:3.90.550.10:FF:000092
      label: Glycogenin 2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 3035 unreviewed entries match.
  - number: 69
    conditions:
    - condition_type: FUNFAM
      value: 3.90.550.10:FF:000148
      curie: CATH.FunFam:3.90.550.10:FF:000148
      label: Glg2p
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0015980 or
      a descendant, 2 of those by a manual-evidence GO annotation. 54 unreviewed entries match.
  go_annotations:
  - go_id: GO:0015980
    go_label: energy derivation by oxidation of organic compounds
    aspect: BP
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 69
review_summary: >-
  All 69 live condition sets were checked against Swiss-Prot. In all but one, every reviewed match
  carries GO:0015980 or a descendant. Set 29 (pyruvate:ferredoxin oxidoreductase FunFams) has 9 reviewed
  matches of which 4 carry the term; the other 5 are annotated to electron transport chain only. One
  set is too wide as written: set 1 requires only the thiamin diphosphate-binding fold in Thermoproteota,
  a condition met by 51 unreviewed acetolactate synthases, which are biosynthetic enzymes.
action: MODIFY
action_rationale: >-
  Glycolysis, the tricarboxylic acid cycle, oxidative phosphorylation and glycogen metabolism are
  all descendants of the rule term, so one rule for them is coherent. The defect found is the breadth
  of set 1. The counts are from Swiss-Prot, which is also what ARBA learns its rules from, so they
  show the condition sets are coherent rather than giving an independent error rate for unreviewed
  entries.
suggested_modifications:
- >-
  Narrow condition set 1 (IPR029061 with taxon Thermoproteota) so that it no longer matches acetolactate
  synthase, for example by requiring a signature specific to 2-oxoacid:ferredoxin oxidoreductases
  in place of the fold-level superfamily.
go_specificity:
  assessment: APPROPRIATE
  notes: >-
    GO:0006096, GO:0006099, GO:0006119, GO:0022904 and GO:0005977 each have GO:0015980 among their
    is_a or part_of ancestors (QuickGO), so the rule term is the shared parent of the pathways the
    sets cover.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0015980
  label: energy derivation by oxidation of organic compounds
  assessment: UNDECIDED
  discriminating_features:
  - >-
    Set 1 matches by fold alone; the reviewed matches are all 2-oxoacid:ferredoxin oxidoreductase
    subunits, while the acetolactate synthases that meet the same conditions are unreviewed.
  correct_examples:
  - Q96Y66
  - P72578
  notes: >-
    UniProtKB release 2026_04: set 1 (IPR029061 AND taxon Thermoproteota) matches 12 reviewed entries,
    all subunits of 2-oxoacid:ferredoxin oxidoreductase such as Q96Y66 and P72578, and 925 unreviewed
    entries. 51 of the unreviewed entries have EC 2.2.1.6, for example A0A2U9INF1 and G7VDF4, named
    Acetolactate synthase by RuleBase RU003591 and annotated to GO:0009099. The UniProtKB record of
    A0A2U9INF1 did not list GO:0015980 when retrieved on 2026-11-10, so the breadth is a property
    of the condition set as published; whether the annotation is emitted for these entries was not
    established.
confidence: 0.6
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    The rule is mechanistically incoherent because it combines unrelated pathways (glycolysis, the
    tricarboxylic acid cycle, electron transport, glycogen metabolism) with no shared functional basis.
  correction: >-
    Each of those pathways is a descendant of the rule term in GO, so the term is exactly what they
    share.
  error_type: ONTOLOGY_MISREAD
  evidence:
  - >-
    QuickGO ancestors (is_a, part_of): GO:0006096, GO:0006099, GO:0006119, GO:0022904 and GO:0005977
    each list GO:0015980.
- date: '2026-11-10'
  withdrawn_claim: The rule should be deprecated because the term is too broad for specific enzymes.
  correction: >-
    A general term that is true is not a wrong annotation. More specific terms can be added without
    removing this one.
  error_type: GENERAL_IS_NOT_WRONG
  evidence:
  - >-
    UniProtKB release 2026_04: in 68 of 69 sets every reviewed match carries GO:0015980 or a descendant.
- date: '2026-11-10'
  withdrawn_claim: >-
    The narrow taxon restrictions contradict the conservation of central metabolism and give a high
    risk of over-annotation.
  correction: >-
    A narrow taxon reduces how many proteins a set reaches and cannot cause over-annotation. Each
    restriction applies to one FunFam or signature, not to a pathway.
  error_type: LOW_RECALL_IS_NOT_WRONG
  evidence:
  - >-
    UniProt ARBA API, ARBA00026991, retrieved 2026-11-09: 48 of 69 condition sets contain a taxon
    condition, each attached to specific FunFam or InterPro conditions.
- date: '2026-11-10'
  withdrawn_claim: 83 condition sets exceed the recommended maximum and the analytical capacity.
  correction: >-
    The number of sets is not evidence about accuracy. All 69 live sets were checked against Swiss-Prot.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'UniProt ARBA API, ARBA00026991: 69 condition sets.'
- date: '2026-11-10'
  withdrawn_claim: >-
    The literature contradicts the rule, and several sets for related enzymes could give conflicting
    annotations.
  correction: >-
    The only source was the review's own research note. A rule with one consequent cannot give conflicting
    annotations.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    The old literature_support block cited only rules/arba/ARBA00026991/ARBA00026991-deep-research-manual.md.
  - 'UniProt ARBA API, ARBA00026991: one annotation, GO:0015980.'