ARBA00027169 Sm-like protein family complex (GO:0120114)

View original ARBA rule on UniProt

Type: ARBA
Status: COMPLETE
Action: ACCEPT
Confidence: 0.80

Description

Assigns GO:0120114 Sm-like protein family complex through 27 alternative condition sets of InterPro and CATH FunFam signatures, some with a taxon. The sets cover Sm and Lsm proteins and other protein components of the U1, U2, U5, U6, U7 and U11/U12 snRNPs.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
27
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00027169 and re-render to add it.

Review Summary

All 27 live condition sets were examined. Every set matches Swiss-Prot entries, and in each at least one matched entry carries GO:0120114 or a descendant with experimental evidence; no matched Swiss-Prot entry lacks the term. Spliceosomal snRNPs are subclasses of GO:0120114 (GO:0030532 small nuclear ribonucleoprotein complex is_a GO:0120114), so snRNP proteins without an Sm fold, such as SF3B1, PRPF8, BRR2 and Snu114, are correctly covered.

Action Rationale

Each set selects snRNP or Lsm-complex components with experimental cellular-component annotation under the rule's term. Narrow taxon conditions on some sets (for example Rattus in set 15) limit coverage but do not make the annotation wrong.

GO Annotations

GO:0120114 - Sm-like protein family complex
Aspect: CC

Annotation Assessments

CORRECT GO_TERM GO:0120114 - Sm-like protein family complex
Matched proteins: ; incorrect:
Correct examples: P62306, P62312, P54999, O22823, Q9M1Z3, Q06406, Q9UUI1, O59734, Q02260, P40070, P43321, O14352, O42661, Q9UUC6, P62310, P57743, Q9LMN4, Q9C6K5, Q9Y7M4, P09012, P08579, P43332, Q8H1S6, O22922, O74968, Q39244, Q06AA4, Q16560, Q8VY74, O13829, O75643, Q9VUV9, P32639, Q9UT24, O75533, Q99NB9, Q15393, Q9W0M7, P33334, O14187

Per-set receipts are in rule.condition_sets[].notes. Accessions listed are Swiss-Prot matches with experimental evidence for GO:0120114 or a descendant in QuickGO (first 40).

Rule Definition

Condition Sets

Condition Set 1

3 condition(s)
Notes:

UniProtKB query, November 2026: 51 Swiss-Prot and 7494 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 8 with experimental evidence, 17 with other manual evidence only, 26 with IEA only, 0 with none. Examples: P62306 (RUXF_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479; P62312 (LSM6_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IDA, PMID:26912367; P54999 (RUXF_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284.

Condition Set 2

3 condition(s)
Notes:

UniProtKB query, November 2026: 6 Swiss-Prot and 4029 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 6 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q02260 (SMD1_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284; P40070 (LSM4_YEAST) GO:0005688 U6 snRNP, IDA, PMID:10369684; P43321 (SMD3_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284.

Condition Set 3

3 condition(s)
Notes:

UniProtKB query, November 2026: 8 Swiss-Prot and 3503 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 3 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P62310 (LSM3_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IDA, PMID:10369684; P57743 (LSM3_YEAST) GO:0005688 U6 snRNP, IDA, PMID:10369684; Q9LMN4 (LSM3A_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288.

Condition Set 4

3 condition(s)
Notes:

UniProtKB query, November 2026: 17 Swiss-Prot and 4431 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 8 with experimental evidence, 9 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P09012 (SNRPA_HUMAN) GO:0005685 U1 snRNP, IDA, PMID:21113136; P08579 (RU2B_HUMAN) GO:0005686 U2 snRNP, IDA, PMID:2951739; P43332 (SNRPA_DROME) GO:0030532 small nuclear ribonucleoprotein complex, IDA, PMID:8846293.

Condition Set 5

1 condition(s)
Notes:

UniProtKB query, November 2026: 6 Swiss-Prot and 2196 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 3 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P62310 (LSM3_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IDA, PMID:10369684; Q9LMN4 (LSM3A_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288; Q9C6K5 (LSM3B_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288.

Condition Set 6

1 condition(s)
Notes:

UniProtKB query, November 2026: 4 Swiss-Prot and 1946 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 1 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P62312 (LSM6_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IDA, PMID:26912367; O22823 (LSM6B_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288; Q9M1Z3 (LSM6A_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288.

Condition Set 7

1 condition(s)
Notes:

UniProtKB query, November 2026: 9 Swiss-Prot and 2089 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 3 with other manual evidence only, 3 with IEA only, 0 with none. Examples: Q16560 (U1SBP_HUMAN) GO:0034693 U11/U12 snRNP, IPI, PMID:15780942; Q8VY74 (U1135_ARATH) GO:0034693 U11/U12 snRNP, IDA, PMID:15987817; O13829 (RU17_SCHPO) GO:0005685 U1 snRNP, IDA, PMID:17264129.

Condition Set 8

3 condition(s)
Notes:

UniProtKB query, November 2026: 4 Swiss-Prot and 994 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 2 with other manual evidence only, 0 with IEA only, 0 with none. Examples: O75643 (U520_HUMAN) GO:0005682 U5 snRNP, IDA, PMID:9539711; Q9VUV9 (U520_DROME) GO:0030532 small nuclear ribonucleoprotein complex, IPI, PMID:24722212.

Condition Set 9

3 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 1168 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P32639 (BRR2_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284; Q9UT24 (BRR2_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.

Condition Set 10

3 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 1181 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence only, 0 with IEA only, 0 with none. Examples: O75533 (SF3B1_HUMAN) GO:0005686 U2 snRNP, IDA, PMID:11252167; Q99NB9 (SF3B1_MOUSE) GO:0005686 U2 snRNP, IDA, PMID:33230114.

Condition Set 11

3 condition(s)
Notes:

UniProtKB query, November 2026: 6 Swiss-Prot and 825 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence only, 1 with IEA only, 0 with none. Examples: Q15393 (SF3B3_HUMAN) GO:0034693 U11/U12 snRNP, IPI, PMID:15780942; Q9W0M7 (SF3B3_DROME) GO:0005686 U2 snRNP, IDA, PMID:27185460.

Condition Set 12

3 condition(s)
Notes:

UniProtKB query, November 2026: 4 Swiss-Prot and 1715 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 2 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P33334 (PRP8_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284; O14187 (SPP42_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.

Condition Set 13

3 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 572 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P36048 (SN114_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284; O94316 (SN114_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.

Condition Set 14

2 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 984 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P43321 (SMD3_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284; Q9UUC6 (SMD3_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:24014766.

Condition Set 15

2 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 3 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P17136 (RSMB_RAT) GO:0005685 U1 snRNP, IDA, PMID:8371979; P63164 (RSMN_RAT) GO:0005685 U1 snRNP, IDA, PMID:8371979.

Condition Set 16

2 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 168 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P83369 (LSM11_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479; Q8BUV6 (LSM11_MOUSE) GO:0005683 U7 snRNP, IDA, PMID:12975319.

Condition Set 17

2 condition(s)
Notes:

UniProtKB query, November 2026: 7 Swiss-Prot and 332 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 5 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P09234 (RU1C_HUMAN) GO:0005685 U1 snRNP, IDA, PMID:15312772; D3ZCL3 (RU1C_RAT) GO:0005685 U1 snRNP, IDA, PMID:16502463.

Condition Set 18

2 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 947 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 1 with experimental evidence, 1 with other manual evidence only, 1 with IEA only, 0 with none. Examples: P57784 (RU2A_MOUSE) GO:0005686 U2 snRNP, IDA, PMID:33230114; P09661 (RU2A_HUMAN) GO:0005686 U2 snRNP, IBA, GO_REF:0000033.

Condition Set 19

1 condition(s)
Notes:

UniProtKB query, November 2026: 6 Swiss-Prot and 1819 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence only, 3 with IEA only, 0 with none. Examples: Q96DI7 (SNR40_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IPI, PMID:30975767; O94620 (CWF17_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.

Condition Set 20

1 condition(s)
Notes:

UniProtKB query, November 2026: 5 Swiss-Prot and 1408 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P62308 (RUXG_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479; Q9VXE0 (RUXG_DROME) GO:0030532 small nuclear ribonucleoprotein complex, IDA, PMID:1834995.

Condition Set 21

1 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 1177 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q06217 (SMD2_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284; O14036 (SMD2_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:24014766.

Condition Set 22

1 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 72 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P40089 (LSM5_YEAST) GO:0005688 U6 snRNP, IDA, PMID:10369684; O42978 (LSM5_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:26292707.

Condition Set 23

1 condition(s)
Notes:

UniProtKB query, November 2026: 5 Swiss-Prot and 1634 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P62316 (SMD2_HUMAN) GO:0005685 U1 snRNP, IDA, PMID:21113136; Q9VI10 (SMD2_DROME) GO:0034693 U11/U12 snRNP, IDA, PMID:33154379.

Condition Set 24

1 condition(s)
Notes:

UniProtKB query, November 2026: 5 Swiss-Prot and 514 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence only, 0 with IEA only, 0 with none. Examples: P62306 (RUXF_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479; O59734 (RUXF_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:24014766.

Condition Set 25

1 condition(s)
Notes:

UniProtKB query, November 2026: 3 Swiss-Prot and 1005 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 1 with IEA only, 0 with none. Examples: P49960 (SART3_YEAST) GO:0005688 U6 snRNP, IDA, PMID:11720284; Q9USY2 (SART3_SCHPO) GO:0005688 U6 snRNP, EXP, PMID:32518066.

Condition Set 26

1 condition(s)
Notes:

UniProtKB query, November 2026: 2 Swiss-Prot and 478 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence only, 0 with IEA only, 0 with none. Examples: Q99181 (HSH49_YEAST) GO:0005686 U2 snRNP, IDA, PMID:15565172; O14102 (SAP49_SCHPO) GO:0005686 U2 snRNP, IDA, PMID:21386897.

Condition Set 27

1 condition(s)
Notes:

UniProtKB query, November 2026: 8 Swiss-Prot and 3553 TrEMBL entries match. QuickGO, GO:0120114 or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 5 with other manual evidence only, 1 with IEA only, 0 with none. Examples: P83876 (TXN4A_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IDA, PMID:26912367; Q06819 (DIB1_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284.

Assessments

STRONG

Curated experimental GO annotations on matched Swiss-Prot entries are listed per set in rule.condition_sets[].notes (QuickGO, November 2026), for example P36048 (SN114_YEAST) GO:0005682 U5 snRNP IDA PMID:11720284 (set 13) and SMD3_YEAST GO:0005682 IDA PMID:11720284 (set 14).

APPROPRIATE

The matched proteins are annotated to different descendants of GO:0120114 (for example GO:0005682 U5 snRNP, GO:0005685 U1 snRNP, GO:0005686 U2 snRNP, GO:0005688 U6 snRNP), so GO:0120114 is the common term across the sets. A per-set snRNP term would be more specific.

Raw YAML

View Source YAML 
id: ARBA00027169
description: Assigns GO:0120114 Sm-like protein family complex through 27 alternative condition sets of
  InterPro and CATH FunFam signatures, some with a taxon. The sets cover Sm and Lsm proteins and other
  protein components of the U1, U2, U5, U6, U7 and U11/U12 snRNPs.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00027169
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR001163
      curie: InterPro:IPR001163
      label: Sm domain, eukaryotic/archaea-type
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR010920
      curie: InterPro:IPR010920
      label: LSM domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR016487
      curie: InterPro:IPR016487
      label: Sm-like protein Lsm6/SmF
      interpro_type: FAMILY
      negated: false
    notes: 'UniProtKB query, November 2026: 51 Swiss-Prot and 7494 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 8 with experimental evidence, 17 with other manual evidence
      only, 26 with IEA only, 0 with none. Examples: P62306 (RUXF_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479;
      P62312 (LSM6_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP complex, IDA, PMID:26912367; P54999 (RUXF_YEAST)
      GO:0005682 U5 snRNP, IDA, PMID:11720284.'
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR027141
      curie: InterPro:IPR027141
      label: Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR047575
      curie: InterPro:IPR047575
      label: Sm domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: '4751'
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'UniProtKB query, November 2026: 6 Swiss-Prot and 4029 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 6 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q02260 (SMD1_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284;
      P40070 (LSM4_YEAST) GO:0005688 U6 snRNP, IDA, PMID:10369684; P43321 (SMD3_YEAST) GO:0005682 U5 snRNP,
      IDA, PMID:11720284.'
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR034105
      curie: InterPro:IPR034105
      label: Sm-like protein Lsm3
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR040002
      curie: InterPro:IPR040002
      label: U6 snRNA-associated Sm-like protein Lsm3
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 8 Swiss-Prot and 3503 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 5 with experimental evidence, 3 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P62310 (LSM3_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP
      complex, IDA, PMID:10369684; P57743 (LSM3_YEAST) GO:0005688 U6 snRNP, IDA, PMID:10369684; Q9LMN4
      (LSM3A_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288.'
  - number: 4
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.330:FF:000029
      curie: CATH.FUNFAM:3.30.70.330:FF:000029
      label: U2 small nuclear ribonucleoprotein B
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.330:FF:000039
      curie: CATH.FUNFAM:3.30.70.330:FF:000039
      label: U1 small nuclear ribonucleoprotein A
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 17 Swiss-Prot and 4431 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 8 with experimental evidence, 9 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P09012 (SNRPA_HUMAN) GO:0005685 U1 snRNP, IDA, PMID:21113136;
      P08579 (RU2B_HUMAN) GO:0005686 U2 snRNP, IDA, PMID:2951739; P43332 (SNRPA_DROME) GO:0030532 small
      nuclear ribonucleoprotein complex, IDA, PMID:8846293.'
  - number: 5
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000007
      curie: CATH.FUNFAM:2.30.30.100:FF:000007
      label: U6 snRNA-associated Sm-like protein LSm3
      negated: false
    notes: 'UniProtKB query, November 2026: 6 Swiss-Prot and 2196 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 3 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P62310 (LSM3_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP
      complex, IDA, PMID:10369684; Q9LMN4 (LSM3A_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288;
      Q9C6K5 (LSM3B_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288.'
  - number: 6
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000010
      curie: CATH.FUNFAM:2.30.30.100:FF:000010
      label: U6 snRNA-associated Sm-like protein LSm6
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 1946 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 1 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P62312 (LSM6_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP
      complex, IDA, PMID:26912367; O22823 (LSM6B_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288;
      Q9M1Z3 (LSM6A_ARATH) GO:0120115 Lsm2-8 complex, IMP, PMID:23620288.'
  - number: 7
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.330:FF:000132
      curie: CATH.FUNFAM:3.30.70.330:FF:000132
      label: Small nuclear ribonucleoprotein U11/U12 subunit 35
      negated: false
    notes: 'UniProtKB query, November 2026: 9 Swiss-Prot and 2089 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 3 with experimental evidence, 3 with other manual evidence
      only, 3 with IEA only, 0 with none. Examples: Q16560 (U1SBP_HUMAN) GO:0034693 U11/U12 snRNP, IPI,
      PMID:15780942; Q8VY74 (U1135_ARATH) GO:0034693 U11/U12 snRNP, IDA, PMID:15987817; O13829 (RU17_SCHPO)
      GO:0005685 U1 snRNP, IDA, PMID:17264129.'
  - number: 8
    conditions:
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000012
      curie: CATH.FUNFAM:1.10.10.10:FF:000012
      label: U5 small nuclear ribonucleoprotein helicase
      negated: false
    - condition_type: FUNFAM
      value: 1.10.10.10:FF:000024
      curie: CATH.FUNFAM:1.10.10.10:FF:000024
      label: U5 small nuclear ribonucleoprotein helicase
      negated: false
    - condition_type: FUNFAM
      value: 1.10.3380.10:FF:000004
      curie: CATH.FUNFAM:1.10.3380.10:FF:000004
      label: U5 small nuclear ribonucleoprotein 200 kDa helicase
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 994 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 2 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: O75643 (U520_HUMAN) GO:0005682 U5 snRNP, IDA, PMID:9539711;
      Q9VUV9 (U520_DROME) GO:0030532 small nuclear ribonucleoprotein complex, IPI, PMID:24722212.'
  - number: 9
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.20:FF:000004
      curie: CATH.FUNFAM:1.10.150.20:FF:000004
      label: U5 small nuclear ribonucleoprotein helicase
      negated: false
    - condition_type: FUNFAM
      value: 1.10.150.20:FF:000013
      curie: CATH.FUNFAM:1.10.150.20:FF:000013
      label: U5 small nuclear ribonucleoprotein kDa helicase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.150:FF:000133
      curie: CATH.FUNFAM:2.60.40.150:FF:000133
      label: Pre-mRNA splicing helicase, putative
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 1168 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P32639 (BRR2_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284;
      Q9UT24 (BRR2_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.'
  - number: 10
    conditions:
    - condition_type: FUNFAM
      value: 1.25.10.10:FF:000088
      curie: CATH.FUNFAM:1.25.10.10:FF:000088
      label: Splicing factor 3b, subunit 1
      negated: false
    - condition_type: FUNFAM
      value: 1.25.10.10:FF:000303
      curie: CATH.FUNFAM:1.25.10.10:FF:000303
      label: splicing factor 3B subunit 1
      negated: false
    - condition_type: FUNFAM
      value: 1.25.10.10:FF:000810
      curie: CATH.FUNFAM:1.25.10.10:FF:000810
      label: Splicing factor 3B subunit 1
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 1181 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: O75533 (SF3B1_HUMAN) GO:0005686 U2 snRNP, IDA, PMID:11252167;
      Q99NB9 (SF3B1_MOUSE) GO:0005686 U2 snRNP, IDA, PMID:33230114.'
  - number: 11
    conditions:
    - condition_type: FUNFAM
      value: 2.130.10.10:FF:000027
      curie: CATH.FUNFAM:2.130.10.10:FF:000027
      label: Splicing factor 3B subunit 3
      negated: false
    - condition_type: FUNFAM
      value: 2.130.10.10:FF:000041
      curie: CATH.FUNFAM:2.130.10.10:FF:000041
      label: Splicing factor 3b subunit 3
      negated: false
    - condition_type: TAXON
      value: '33208'
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'UniProtKB query, November 2026: 6 Swiss-Prot and 825 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: Q15393 (SF3B3_HUMAN) GO:0034693 U11/U12 snRNP, IPI,
      PMID:15780942; Q9W0M7 (SF3B3_DROME) GO:0005686 U2 snRNP, IDA, PMID:27185460.'
  - number: 12
    conditions:
    - condition_type: FUNFAM
      value: 3.30.420.230:FF:000001
      curie: CATH.FUNFAM:3.30.420.230:FF:000001
      label: Pre-mRNA-processing-splicing factor 8
      negated: false
    - condition_type: FUNFAM
      value: 3.40.140.10:FF:000002
      curie: CATH.FUNFAM:3.40.140.10:FF:000002
      label: Pre-mRNA-processing-splicing factor 8
      negated: false
    - condition_type: FUNFAM
      value: 3.90.1570.40:FF:000001
      curie: CATH.FUNFAM:3.90.1570.40:FF:000001
      label: Pre-mRNA-processing-splicing factor 8
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 1715 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 2 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P33334 (PRP8_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284;
      O14187 (SPP42_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.'
  - number: 13
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.870:FF:000002
      curie: CATH.FUNFAM:3.30.70.870:FF:000002
      label: Translation elongation factor 2
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.300:FF:000646
      curie: CATH.FUNFAM:3.40.50.300:FF:000646
      label: U5 small nuclear ribonucleoprotein component
      negated: false
    - condition_type: TAXON
      value: '4751'
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 572 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P36048 (SN114_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284;
      O94316 (SN114_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.'
  - number: 14
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000002
      curie: CATH.FUNFAM:2.30.30.100:FF:000002
      label: Small nuclear ribonucleoprotein Sm D3
      negated: false
    - condition_type: TAXON
      value: '4890'
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 984 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P43321 (SMD3_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284;
      Q9UUC6 (SMD3_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:24014766.'
  - number: 15
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000004
      curie: CATH.FUNFAM:2.30.30.100:FF:000004
      label: Small nuclear ribonucleoprotein-associated proteins
      negated: false
    - condition_type: TAXON
      value: '10114'
      curie: NCBITaxon:10114
      label: Rattus
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 3 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P17136 (RSMB_RAT) GO:0005685 U1 snRNP, IDA, PMID:8371979;
      P63164 (RSMN_RAT) GO:0005685 U1 snRNP, IDA, PMID:8371979.'
  - number: 16
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000158
      curie: CATH.FUNFAM:2.30.30.100:FF:000158
      label: LSM11, U7 small nuclear RNA associated
      negated: false
    - condition_type: TAXON
      value: '7711'
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 168 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P83369 (LSM11_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479;
      Q8BUV6 (LSM11_MOUSE) GO:0005683 U7 snRNP, IDA, PMID:12975319.'
  - number: 17
    conditions:
    - condition_type: FUNFAM
      value: 3.30.160.60:FF:000059
      curie: CATH.FUNFAM:3.30.160.60:FF:000059
      label: U1 small nuclear ribonucleoprotein C
      negated: false
    - condition_type: TAXON
      value: '40674'
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: 'UniProtKB query, November 2026: 7 Swiss-Prot and 332 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 5 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P09234 (RU1C_HUMAN) GO:0005685 U1 snRNP, IDA, PMID:15312772;
      D3ZCL3 (RU1C_RAT) GO:0005685 U1 snRNP, IDA, PMID:16502463.'
  - number: 18
    conditions:
    - condition_type: FUNFAM
      value: 3.80.10.10:FF:000026
      curie: CATH.FUNFAM:3.80.10.10:FF:000026
      label: U2 small nuclear ribonucleoprotein A
      negated: false
    - condition_type: TAXON
      value: '89593'
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 947 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 1 with experimental evidence, 1 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P57784 (RU2A_MOUSE) GO:0005686 U2 snRNP, IDA, PMID:33230114;
      P09661 (RU2A_HUMAN) GO:0005686 U2 snRNP, IBA, GO_REF:0000033.'
  - number: 19
    conditions:
    - condition_type: FUNFAM
      value: 2.130.10.10:FF:000229
      curie: CATH.FUNFAM:2.130.10.10:FF:000229
      label: Small nuclear ribonucleoprotein U5 subunit 40
      negated: false
    notes: 'UniProtKB query, November 2026: 6 Swiss-Prot and 1819 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 3 with IEA only, 0 with none. Examples: Q96DI7 (SNR40_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP
      complex, IPI, PMID:30975767; O94620 (CWF17_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:21386897.'
  - number: 20
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000017
      curie: CATH.FUNFAM:2.30.30.100:FF:000017
      label: Small nuclear ribonucleoprotein G
      negated: false
    notes: 'UniProtKB query, November 2026: 5 Swiss-Prot and 1408 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P62308 (RUXG_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479;
      Q9VXE0 (RUXG_DROME) GO:0030532 small nuclear ribonucleoprotein complex, IDA, PMID:1834995.'
  - number: 21
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000018
      curie: CATH.FUNFAM:2.30.30.100:FF:000018
      label: Small nuclear ribonucleoprotein Sm D2
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 1177 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q06217 (SMD2_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284;
      O14036 (SMD2_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:24014766.'
  - number: 22
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000067
      curie: CATH.FUNFAM:2.30.30.100:FF:000067
      label: U6 snRNA-associated Sm-like protein LSm5
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 72 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P40089 (LSM5_YEAST) GO:0005688 U6 snRNP, IDA, PMID:10369684;
      O42978 (LSM5_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:26292707.'
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000069
      curie: CATH.FUNFAM:2.30.30.100:FF:000069
      label: Small nuclear ribonucleoprotein Sm D2
      negated: false
    notes: 'UniProtKB query, November 2026: 5 Swiss-Prot and 1634 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P62316 (SMD2_HUMAN) GO:0005685 U1 snRNP, IDA, PMID:21113136;
      Q9VI10 (SMD2_DROME) GO:0034693 U11/U12 snRNP, IDA, PMID:33154379.'
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.100:FF:000133
      curie: CATH.FUNFAM:2.30.30.100:FF:000133
      label: Small nuclear ribonucleoprotein F
      negated: false
    notes: 'UniProtKB query, November 2026: 5 Swiss-Prot and 514 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 3 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P62306 (RUXF_HUMAN) GO:0005683 U7 snRNP, IDA, PMID:11574479;
      O59734 (RUXF_SCHPO) GO:0005682 U5 snRNP, IDA, PMID:24014766.'
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.330:FF:000365
      curie: CATH.FUNFAM:3.30.70.330:FF:000365
      label: U4/U6 snRNA-associated-splicing factor PRP24
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 1005 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P49960 (SART3_YEAST) GO:0005688 U6 snRNP, IDA, PMID:11720284;
      Q9USY2 (SART3_SCHPO) GO:0005688 U6 snRNP, EXP, PMID:32518066.'
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.330:FF:000895
      curie: CATH.FUNFAM:3.30.70.330:FF:000895
      label: Hsh49p
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 478 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: Q99181 (HSH49_YEAST) GO:0005686 U2 snRNP, IDA, PMID:15565172;
      O14102 (SAP49_SCHPO) GO:0005686 U2 snRNP, IDA, PMID:21386897.'
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 3.40.30.10:FF:000004
      curie: CATH.FUNFAM:3.40.30.10:FF:000004
      label: Spliceosomal protein DIB1
      negated: false
    notes: 'UniProtKB query, November 2026: 8 Swiss-Prot and 3553 TrEMBL entries match. QuickGO, GO:0120114
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 5 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P83876 (TXN4A_HUMAN) GO:0046540 U4/U6 x U5 tri-snRNP
      complex, IDA, PMID:26912367; Q06819 (DIB1_YEAST) GO:0005682 U5 snRNP, IDA, PMID:11720284.'
  go_annotations:
  - go_id: GO:0120114
    go_label: Sm-like protein family complex
    aspect: CC
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 27
review_summary: All 27 live condition sets were examined. Every set matches Swiss-Prot entries, and in
  each at least one matched entry carries GO:0120114 or a descendant with experimental evidence; no matched
  Swiss-Prot entry lacks the term. Spliceosomal snRNPs are subclasses of GO:0120114 (GO:0030532 small
  nuclear ribonucleoprotein complex is_a GO:0120114), so snRNP proteins without an Sm fold, such as SF3B1,
  PRPF8, BRR2 and Snu114, are correctly covered.
action: ACCEPT
action_rationale: Each set selects snRNP or Lsm-complex components with experimental cellular-component
  annotation under the rule's term. Narrow taxon conditions on some sets (for example Rattus in set 15)
  limit coverage but do not make the annotation wrong.
literature_support:
  assessment: STRONG
  notes: Curated experimental GO annotations on matched Swiss-Prot entries are listed per set in rule.condition_sets[].notes
    (QuickGO, November 2026), for example P36048 (SN114_YEAST) GO:0005682 U5 snRNP IDA PMID:11720284 (set
    13) and SMD3_YEAST GO:0005682 IDA PMID:11720284 (set 14).
go_specificity:
  assessment: APPROPRIATE
  notes: The matched proteins are annotated to different descendants of GO:0120114 (for example GO:0005682
    U5 snRNP, GO:0005685 U1 snRNP, GO:0005686 U2 snRNP, GO:0005688 U6 snRNP), so GO:0120114 is the common
    term across the sets. A per-set snRNP term would be more specific.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0120114
  label: Sm-like protein family complex
  assessment: CORRECT
  correct_examples:
  - P62306
  - P62312
  - P54999
  - O22823
  - Q9M1Z3
  - Q06406
  - Q9UUI1
  - O59734
  - Q02260
  - P40070
  - P43321
  - O14352
  - O42661
  - Q9UUC6
  - P62310
  - P57743
  - Q9LMN4
  - Q9C6K5
  - Q9Y7M4
  - P09012
  - P08579
  - P43332
  - Q8H1S6
  - O22922
  - O74968
  - Q39244
  - Q06AA4
  - Q16560
  - Q8VY74
  - O13829
  - O75643
  - Q9VUV9
  - P32639
  - Q9UT24
  - O75533
  - Q99NB9
  - Q15393
  - Q9W0M7
  - P33334
  - O14187
  notes: Per-set receipts are in rule.condition_sets[].notes. Accessions listed are Swiss-Prot matches
    with experimental evidence for GO:0120114 or a descendant in QuickGO (first 40).
confidence: 0.8
corrections:
- date: '2026-11-10'
  withdrawn_claim: Condition set 13 wrongly includes a translation elongation factor and should be removed.
  correction: Set 13 is a conjunction of two FunFams with Fungi. Its Swiss-Prot matches are Snu114 and
    its fission yeast ortholog, the EF-2-like GTPase of the U5 snRNP.
  error_type: CONJUNCTION_IGNORED
  evidence:
  - 'UniProtKB query (xref:"funfam-3.30.70.870:FF:000002") AND (xref:"funfam-3.40.50.300:FF:000646") AND
    (taxonomy_id:4751) AND (reviewed:true): P36048 (SN114_YEAST), O94316 (SN114_SCHPO)'
  - P36048 GO:0005682 U5 snRNP, IDA, PMID:11720284 and PMID:11720285
  - O94316 GO:0005682 IDA PMID:21386897 and PMID:24014766
- date: '2026-11-10'
  withdrawn_claim: The rule captures spliceosomal components without Sm domains, which do not belong under
    "Sm-like protein family complex".
  correction: GO:0120114 is a complex term whose subclasses include the snRNPs, so any snRNP subunit is
    part of it whether or not it has an Sm fold.
  error_type: ONTOLOGY_MISREAD
  evidence:
  - QuickGO ancestors of GO:0005682 U5 snRNP include GO:0030532 small nuclear ribonucleoprotein complex
    and GO:0120114 Sm-like protein family complex
- date: '2026-11-10'
  withdrawn_claim: GO:0071004 "U2-type spliceosomal complex" would be a more specific term.
  correction: GO:0071004 is U2-type prespliceosome and is not a descendant of GO:0120114.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'QuickGO: GO:0071004 U2-type prespliceosome; its ancestors do not include GO:0120114'
- date: '2026-11-10'
  withdrawn_claim: 28 condition sets exceed the 12 condition limit for analysis, which justifies deprecation.
  correction: The limit is the default of this repository's overlap-analysis tool, not a property of the
    rule. All 27 live sets were checked individually.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'src/ai_gene_review/etl/rule_analysis.py: max_condition_sets: int = 12'
  - Per-set evidence in rule.condition_sets[].notes
- date: '2026-11-10'
  withdrawn_claim: Taxonomic scope is inconsistent (Eukaryota to Rattus), so the rule may annotate proteins
    inappropriately.
  correction: A narrow taxon condition makes a set fire on fewer proteins; it cannot cause a wrong annotation.
  error_type: TAXON_MISREAD
  evidence:
  - 'Set 15 (Rattus): Swiss-Prot matches RSMB_RAT and RSMN_RAT, both with GO:0120114 descendants (rule.condition_sets[14].notes)'