ARBA00027399 serine-type peptidase activity (GO:0008236)

View original ARBA rule on UniProt

Type: ARBA
Status: COMPLETE
Action: MODIFY
Confidence: 0.70

Description

Assigns GO:0008236 (serine-type peptidase activity) through 45 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover coagulation and complement proteases, trypsin-family enzymes, subtilisin-like proprotein convertases, HtrA/DegP proteases, tripeptidyl peptidases and others.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
45
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00027399 and re-render to add it.

Review Summary

All 45 live condition sets were checked against Swiss-Prot. They match 292 reviewed entries in total and every one carries GO:0008236 or a descendant, 225 by manual evidence. One set is wrong: set 13 selects BMP1 and the tolloid-like proteins, which are zinc metalloproteases. They carry a serine-type endopeptidase term only through a Reactome TAS annotation, and the rule passes that term on to 134 unreviewed entries. The other sets were checked by counts only.

Action Rationale

Set 13 propagates a serine-type activity to zinc metalloproteases of MEROPS family M12 and should be removed. No defect was found in the other 44 sets. The counts are from Swiss-Prot, which is also what ARBA learns its rules from, so they show the condition sets are coherent rather than giving an independent error rate for unreviewed entries.

GO Annotations

GO:0008236 - serine-type peptidase activity
Aspect: MF

Annotation Assessments

PARTIALLY_CORRECT GO_TERM GO:0008236 - serine-type peptidase activity
Matched proteins: 292; incorrect: 3
Discriminating features: The reviewed matches of set 13 are members of MEROPS family M12 with a zinc cofactor, not serine peptidases.
Incorrect examples: P13497, O43897, Q9Y6L7

Set 13: P13497 (human BMP1), UniProtKB EC 3.4.24.19, cofactor Zn(2+), MEROPS M12.005; O43897 (TLL1), EC 3.4.24.-, MEROPS M12.016; Q9Y6L7 (TLL2), EC 3.4.24.-, MEROPS M12.018. Each carries GO:0004222 by IBA and carries GO:0004252 only as TAS from Reactome:R-HSA-2214330 (QuickGO, retrieved 2026-11-09). Set 12: the reviewed matches are Escherichia coli L,D-transpeptidases such as P0AAX8 (ybiS), annotated to GO:0071972 by IDA, PMID:17369299; QuickGO lists GO:0008236 among the ancestors of GO:0071972, so they count as carrying a descendant.

Rule Definition

Condition Sets

Condition Set 1

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0008236 or a descendant, 13 of those by a manual-evidence GO annotation. 478 unreviewed entries match.

Condition Set 2

3 condition(s)
Notes:

UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0008236 or a descendant, 16 of those by a manual-evidence GO annotation. 652 unreviewed entries match.

Condition Set 3

3 condition(s)
Notes:

UniProtKB release 2026_04: 38 reviewed entries match this set; 38 of them carry GO:0008236 or a descendant, 11 of those by a manual-evidence GO annotation. 9741 unreviewed entries match.

Condition Set 4

3 condition(s)
Notes:

UniProtKB release 2026_04: 15 reviewed entries match this set; 15 of them carry GO:0008236 or a descendant, 15 of those by a manual-evidence GO annotation. 415 unreviewed entries match.

Condition Set 5

3 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0008236 or a descendant, 9 of those by a manual-evidence GO annotation. 367 unreviewed entries match.

Condition Set 6

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0008236 or a descendant, 8 of those by a manual-evidence GO annotation. 1680 unreviewed entries match.

Condition Set 7

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0008236 or a descendant, 11 of those by a manual-evidence GO annotation. 49 unreviewed entries match.

Condition Set 8

2 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0008236 or a descendant, 8 of those by a manual-evidence GO annotation. 1308 unreviewed entries match.

Condition Set 9

3 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or a descendant, 4 of those by a manual-evidence GO annotation. 178 unreviewed entries match.

Condition Set 10

3 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0008236 or a descendant, 7 of those by a manual-evidence GO annotation. 262 unreviewed entries match.

Condition Set 11

2 condition(s)
Notes:

UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0008236 or a descendant, 7 of those by a manual-evidence GO annotation. 1641 unreviewed entries match.

Condition Set 12

2 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0008236 or a descendant, 5 of those by a manual-evidence GO annotation. 1552 unreviewed entries match. Reviewed matches are L,D-transpeptidases annotated to GO:0071972, which has GO:0008236 among its ancestors.

Condition Set 13

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 134 unreviewed entries match. The three reviewed matches are P13497 (BMP1), O43897 (TLL1) and Q9Y6L7 (TLL2), zinc metalloendopeptidases of MEROPS family M12 that carry GO:0004252 only as a Reactome TAS annotation. This set should be removed.

Condition Set 14

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 142 unreviewed entries match.

Condition Set 15

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0008236 or a descendant, 7 of those by a manual-evidence GO annotation. 361 unreviewed entries match.

Condition Set 16

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 39 unreviewed entries match.

Condition Set 17

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or a descendant, 4 of those by a manual-evidence GO annotation. 266 unreviewed entries match.

Condition Set 18

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0008236 or a descendant, 6 of those by a manual-evidence GO annotation. 298 unreviewed entries match.

Condition Set 19

2 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 289 unreviewed entries match.

Condition Set 20

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 930 unreviewed entries match.

Condition Set 21

2 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0008236 or a descendant, 8 of those by a manual-evidence GO annotation. 246 unreviewed entries match.

Condition Set 22

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 31 unreviewed entries match.

Condition Set 23

1 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 2949 unreviewed entries match.

Condition Set 24

1 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0008236 or a descendant, 6 of those by a manual-evidence GO annotation. 1586 unreviewed entries match.

Condition Set 25

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 318 unreviewed entries match.

Condition Set 26

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 96 unreviewed entries match.

Condition Set 27

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0008236 or a descendant, 5 of those by a manual-evidence GO annotation. 963 unreviewed entries match.

Condition Set 28

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 43 unreviewed entries match.

Condition Set 29

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 502 unreviewed entries match.

Condition Set 30

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 922 unreviewed entries match.

Condition Set 31

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0008236 or a descendant, 6 of those by a manual-evidence GO annotation. 195 unreviewed entries match.

Condition Set 32

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 34 unreviewed entries match.

Condition Set 33

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 1394 unreviewed entries match.

Condition Set 34

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 25 unreviewed entries match.

Condition Set 35

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 28 unreviewed entries match.

Condition Set 36

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 264 unreviewed entries match.

Condition Set 37

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 362 unreviewed entries match.

Condition Set 38

2 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0008236 or a descendant, 8 of those by a manual-evidence GO annotation. 736 unreviewed entries match.

Condition Set 39

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.

Condition Set 40

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 20 unreviewed entries match.

Condition Set 41

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.

Condition Set 42

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 36 unreviewed entries match.

Condition Set 43

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.

Condition Set 44

1 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or a descendant, 2 of those by a manual-evidence GO annotation. 360 unreviewed entries match.

Condition Set 45

1 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or a descendant, 3 of those by a manual-evidence GO annotation. 724 unreviewed entries match.

Assessments

Raw YAML

View Source YAML 
id: ARBA00027399
description: >-
  Assigns GO:0008236 (serine-type peptidase activity) through 45 alternative condition sets built
  from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover coagulation
  and complement proteases, trypsin-family enzymes, subtilisin-like proprotein convertases, HtrA/DegP
  proteases, tripeptidyl peptidases and others.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00027399
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR001254
      curie: InterPro:IPR001254
      label: Serine proteases, trypsin domain
      negated: false
    - condition_type: INTERPRO
      value: IPR018097
      curie: InterPro:IPR018097
      label: EGF-like calcium-binding, conserved site
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0008236 or
      a descendant, 13 of those by a manual-evidence GO annotation. 478 unreviewed entries match.
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR000152
      curie: InterPro:IPR000152
      label: EGF-type aspartate/asparagine hydroxylation site
      negated: false
    - condition_type: INTERPRO
      value: IPR000294
      curie: InterPro:IPR000294
      label: Gamma-carboxyglutamic acid-rich (GLA) domain
      negated: false
    - condition_type: PANTHER
      value: PTHR24278:SF28
      curie: PANTHER:PTHR24278:SF28
      label: COAGULATION FACTOR X
      negated: false
    notes: >-
      UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0008236 or
      a descendant, 16 of those by a manual-evidence GO annotation. 652 unreviewed entries match.
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR000209
      curie: InterPro:IPR000209
      label: Peptidase S8/S53 domain
      negated: false
    - condition_type: INTERPRO
      value: IPR015500
      curie: InterPro:IPR015500
      label: Peptidase S8, subtilisin-related
      negated: false
    - condition_type: TAXON
      value: Bacillota
      curie: NCBITaxon:1239
      label: Bacillota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 38 reviewed entries match this set; 38 of them carry GO:0008236 or
      a descendant, 11 of those by a manual-evidence GO annotation. 9741 unreviewed entries match.
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR000436
      curie: InterPro:IPR000436
      label: Sushi/SCR/CCP domain
      negated: false
    - condition_type: INTERPRO
      value: IPR033116
      curie: InterPro:IPR033116
      label: Serine proteases, trypsin family, serine active site
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 15 reviewed entries match this set; 15 of them carry GO:0008236 or
      a descendant, 15 of those by a manual-evidence GO annotation. 415 unreviewed entries match.
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR000859
      curie: InterPro:IPR000859
      label: CUB domain
      negated: false
    - condition_type: PANTHER
      value: PTHR24255
      curie: PANTHER:PTHR24255
      label: COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED
      negated: false
    - condition_type: TAXON
      value: Catarrhini
      curie: NCBITaxon:9526
      label: Catarrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0008236 or
      a descendant, 9 of those by a manual-evidence GO annotation. 367 unreviewed entries match.
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR002884
      curie: InterPro:IPR002884
      label: P domain
      negated: false
    - condition_type: INTERPRO
      value: IPR008979
      curie: InterPro:IPR008979
      label: Galactose-binding-like domain superfamily
      negated: false
    - condition_type: PANTHER
      value: PTHR42884:SF13
      curie: PANTHER:PTHR42884:SF13
      label: NEUROENDOCRINE CONVERTASE 2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0008236 or
      a descendant, 8 of those by a manual-evidence GO annotation. 1680 unreviewed entries match.
  - number: 7
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000162
      curie: CATH.FunFam:2.10.25.10:FF:000162
      label: Coagulation factor X (Predicted)
      negated: false
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000513
      curie: CATH.FunFam:2.10.25.10:FF:000513
      label: Coagulation factor VII
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000011
      curie: CATH.FunFam:2.40.10.10:FF:000011
      label: Coagulation factor X
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0008236 or
      a descendant, 11 of those by a manual-evidence GO annotation. 49 unreviewed entries match.
  - number: 8
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000004
      curie: CATH.FunFam:3.40.50.200:FF:000004
      label: Proprotein convertase type 2
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0008236 or
      a descendant, 8 of those by a manual-evidence GO annotation. 1308 unreviewed entries match.
  - number: 9
    conditions:
    - condition_type: FUNFAM
      value: 2.10.220.10:FF:000023
      curie: CATH.FunFam:2.10.220.10:FF:000023
      label: Furin, paired basic amino acid cleaving enzyme
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000034
      curie: CATH.FunFam:2.60.120.260:FF:000034
      label: furin isoform X2
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.850:FF:000001
      curie: CATH.FunFam:3.30.70.850:FF:000001
      label: Proprotein convertase subtilisin/kexin type 5
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or
      a descendant, 4 of those by a manual-evidence GO annotation. 178 unreviewed entries match.
  - number: 10
    conditions:
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000016
      curie: CATH.FunFam:2.10.70.10:FF:000016
      label: Mannan-binding lectin serine protease 1
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000006
      curie: CATH.FunFam:2.60.120.290:FF:000006
      label: Mannan-binding lectin serine protease 1
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0008236 or
      a descendant, 7 of those by a manual-evidence GO annotation. 262 unreviewed entries match.
  - number: 11
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000054
      curie: CATH.FunFam:2.40.10.10:FF:000054
      label: Complement C1r subcomponent
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0008236 or
      a descendant, 7 of those by a manual-evidence GO annotation. 1641 unreviewed entries match.
  - number: 12
    conditions:
    - condition_type: FUNFAM
      value: 2.40.440.10:FF:000001
      curie: CATH.FunFam:2.40.440.10:FF:000001
      label: L,D-transpeptidase YbiS
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0008236 or
      a descendant, 5 of those by a manual-evidence GO annotation. 1552 unreviewed entries match.
      Reviewed matches are L,D-transpeptidases annotated to GO:0071972, which has GO:0008236 among
      its ancestors.
  - number: 13
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000022
      curie: CATH.FunFam:2.10.25.10:FF:000022
      label: Metalloendopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000004
      curie: CATH.FunFam:2.60.120.290:FF:000004
      label: Metalloendopeptidase
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 134 unreviewed entries match. The
      three reviewed matches are P13497 (BMP1), O43897 (TLL1) and Q9Y6L7 (TLL2), zinc metalloendopeptidases
      of MEROPS family M12 that carry GO:0004252 only as a Reactome TAS annotation. This set should
      be removed.
  - number: 14
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000059
      curie: CATH.FunFam:2.10.25.10:FF:000059
      label: Mannan-binding lectin serine protease 1
      negated: false
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000028
      curie: CATH.FunFam:2.10.70.10:FF:000028
      label: mannan-binding lectin serine protease 1 isoform X2
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000015
      curie: CATH.FunFam:2.40.10.10:FF:000015
      label: Atrial natriuretic peptide-converting enzyme
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 142 unreviewed entries match.
  - number: 15
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000005
      curie: CATH.FunFam:2.40.10.10:FF:000005
      label: Serine protease 37
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000014
      curie: CATH.FunFam:2.40.10.10:FF:000014
      label: Complement factor D
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0008236 or
      a descendant, 7 of those by a manual-evidence GO annotation. 361 unreviewed entries match.
  - number: 16
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000019
      curie: CATH.FunFam:2.40.10.10:FF:000019
      label: Anionic trypsin
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000248
      curie: CATH.FunFam:2.40.10.10:FF:000248
      label: Anionic trypsin-2
      negated: false
    - condition_type: TAXON
      value: Mus
      curie: NCBITaxon:10088
      label: Mus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 39 unreviewed entries match.
  - number: 17
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000041
      curie: CATH.FunFam:2.40.10.10:FF:000041
      label: kallikrein-6 isoform X2
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or
      a descendant, 4 of those by a manual-evidence GO annotation. 266 unreviewed entries match.
  - number: 18
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000052
      curie: CATH.FunFam:2.40.10.10:FF:000052
      label: Neutrophil elastase
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0008236 or
      a descendant, 6 of those by a manual-evidence GO annotation. 298 unreviewed entries match.
  - number: 19
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000005
      curie: CATH.FunFam:3.40.50.1820:FF:000005
      label: Prolyl endopeptidase
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 289 unreviewed entries match.
  - number: 20
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000001
      curie: CATH.FunFam:3.40.50.200:FF:000001
      label: Furin 2, isoform B
      negated: false
    - condition_type: TAXON
      value: Arthropoda
      curie: NCBITaxon:6656
      label: Arthropoda
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 930 unreviewed entries match.
  - number: 21
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000012
      curie: CATH.FunFam:3.40.50.200:FF:000012
      label: Tripeptidyl-peptidase 1 preproprotein
      negated: false
    - condition_type: TAXON
      value: Eutheria
      curie: NCBITaxon:9347
      label: Eutheria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0008236 or
      a descendant, 8 of those by a manual-evidence GO annotation. 246 unreviewed entries match.
  - number: 22
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000055
      curie: CATH.FunFam:3.40.50.200:FF:000055
      label: Tk-subtilisin
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 31 unreviewed entries match.
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000146
      curie: CATH.FunFam:2.40.10.10:FF:000146
      label: Serine protease 53
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 2949 unreviewed entries match.
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000009
      curie: CATH.FunFam:3.40.50.200:FF:000009
      label: tripeptidyl-peptidase 2 isoform X1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0008236 or
      a descendant, 6 of those by a manual-evidence GO annotation. 1586 unreviewed entries match.
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 1.10.2000.10:FF:000011
      curie: CATH.FunFam:1.10.2000.10:FF:000011
      label: Corin, serine peptidase
      negated: false
    - condition_type: FUNFAM
      value: 1.10.2000.10:FF:000013
      curie: CATH.FunFam:1.10.2000.10:FF:000013
      label: atrial natriuretic peptide-converting enzyme
      negated: false
    - condition_type: FUNFAM
      value: 4.10.400.10:FF:000024
      curie: CATH.FunFam:4.10.400.10:FF:000024
      label: Low-density lipoprotein RecePtor related
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 318 unreviewed entries match.
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000266
      curie: CATH.FunFam:2.10.25.10:FF:000266
      label: Urokinase-type plasminogen activator
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000065
      curie: CATH.FunFam:2.40.10.10:FF:000065
      label: Urokinase-type plasminogen activator
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 96 unreviewed entries match.
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 2.30.42.10:FF:000037
      curie: CATH.FunFam:2.30.42.10:FF:000037
      label: Periplasmic serine endoprotease DegP-like
      negated: false
    - condition_type: FUNFAM
      value: 2.30.42.10:FF:000050
      curie: CATH.FunFam:2.30.42.10:FF:000050
      label: Periplasmic serine endoprotease DegP-like
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.120:FF:000001
      curie: CATH.FunFam:2.40.10.120:FF:000001
      label: Periplasmic serine endoprotease DegP-like
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0008236 or
      a descendant, 5 of those by a manual-evidence GO annotation. 963 unreviewed entries match.
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 2.30.42.10:FF:000181
      curie: CATH.FunFam:2.30.42.10:FF:000181
      label: Putative serine protease HTRA3
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.120:FF:000002
      curie: CATH.FunFam:2.40.10.120:FF:000002
      label: HtrA serine peptidase 3
      negated: false
    - condition_type: FUNFAM
      value: 4.10.40.20:FF:000004
      curie: CATH.FunFam:4.10.40.20:FF:000004
      label: HtrA serine peptidase 3
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 43 unreviewed entries match.
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000003
      curie: CATH.FunFam:2.40.10.10:FF:000003
      label: Transmembrane serine protease 3
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000032
      curie: CATH.FunFam:2.60.120.290:FF:000032
      label: Suppressor of tumorigenicity 14 protein homolog
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000036
      curie: CATH.FunFam:2.60.120.290:FF:000036
      label: Suppressor of tumorigenicity 14 protein homolog
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 502 unreviewed entries match.
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000012
      curie: CATH.FunFam:2.40.10.10:FF:000012
      label: protease Do-like 9
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000131
      curie: CATH.FunFam:2.40.10.10:FF:000131
      label: Protease Do-like 9
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 922 unreviewed entries match.
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000053
      curie: CATH.FunFam:2.40.10.10:FF:000053
      label: Neurotrypsin
      negated: false
    - condition_type: FUNFAM
      value: 2.40.20.10:FF:000010
      curie: CATH.FunFam:2.40.20.10:FF:000010
      label: Neurotrypsin
      negated: false
    - condition_type: FUNFAM
      value: 3.10.250.10:FF:000005
      curie: CATH.FunFam:3.10.250.10:FF:000005
      label: Neurotrypsin isoform A
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0008236 or
      a descendant, 6 of those by a manual-evidence GO annotation. 195 unreviewed entries match.
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000118
      curie: CATH.FunFam:2.40.10.10:FF:000118
      label: Chymotrypsinogen A
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000176
      curie: CATH.FunFam:2.40.10.10:FF:000176
      label: Chymotrypsinogen A
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 34 unreviewed entries match.
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000026
      curie: CATH.FunFam:2.60.120.260:FF:000026
      label: proprotein convertase subtilisin/kexin type 7
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000005
      curie: CATH.FunFam:3.40.50.200:FF:000005
      label: Proprotein convertase subtilisin/kexin type 7
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 1394 unreviewed entries match.
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000054
      curie: CATH.FunFam:2.60.120.260:FF:000054
      label: Proprotein convertase subtilisin/kexin type 1
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000010
      curie: CATH.FunFam:3.40.50.200:FF:000010
      label: Putative neuroendocrine convertase 1
      negated: false
    - condition_type: TAXON
      value: Rodentia
      curie: NCBITaxon:9989
      label: Rodentia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 25 unreviewed entries match.
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.2310:FF:000004
      curie: CATH.FunFam:2.60.40.2310:FF:000004
      label: Subtilisin-like protease SBT3
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.80:FF:000003
      curie: CATH.FunFam:3.30.70.80:FF:000003
      label: Subtilisin-like protease SBT1.9
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000006
      curie: CATH.FunFam:3.40.50.200:FF:000006
      label: Subtilisin-like protease SBT1.5
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 28 unreviewed entries match.
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 1.10.287.410:FF:000001
      curie: CATH.FunFam:1.10.287.410:FF:000001
      label: Carboxypeptidase Y
      negated: false
    - condition_type: TAXON
      value: Saccharomycotina
      curie: NCBITaxon:147537
      label: Saccharomycotina
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 264 unreviewed entries match.
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1540.10:FF:000012
      curie: CATH.FunFam:1.20.1540.10:FF:000012
      label: Rhomboid family protein
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 362 unreviewed entries match.
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000122
      curie: CATH.FunFam:2.40.10.10:FF:000122
      label: Chymotrypsin-like elastase family member 1
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000280
      curie: CATH.FunFam:2.40.10.10:FF:000280
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0008236 or
      a descendant, 8 of those by a manual-evidence GO annotation. 736 unreviewed entries match.
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000012
      curie: CATH.FunFam:2.60.120.290:FF:000012
      label: mannan-binding lectin serine protease 1 isoform X1
      negated: false
    - condition_type: TAXON
      value: Rattus
      curie: NCBITaxon:10114
      label: Rattus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000007
      curie: CATH.FunFam:3.40.50.200:FF:000007
      label: Subtilisin-like serine protease
      negated: false
    - condition_type: TAXON
      value: Taphrinomycotina
      curie: NCBITaxon:451866
      label: Taphrinomycotina
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 20 unreviewed entries match.
  - number: 41
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000008
      curie: CATH.FunFam:3.40.50.200:FF:000008
      label: Membrane-bound transcription factor site-1 protease preproprotein
      negated: false
    - condition_type: TAXON
      value: Muridae
      curie: NCBITaxon:10066
      label: Muridae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.
  - number: 42
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000014
      curie: CATH.FunFam:3.40.50.200:FF:000014
      label: Proteinase K
      negated: false
    - condition_type: TAXON
      value: Penicillium
      curie: NCBITaxon:5073
      label: Penicillium
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 36 unreviewed entries match.
  - number: 43
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000023
      curie: CATH.FunFam:3.40.50.200:FF:000023
      label: Subtilisin-like protease 1
      negated: false
    - condition_type: TAXON
      value: Sar
      curie: NCBITaxon:2698737
      label: Sar
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.
  - number: 44
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000080
      curie: CATH.FunFam:2.40.10.10:FF:000080
      label: peroxisomal leader peptide-processing protease
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0008236 or
      a descendant, 2 of those by a manual-evidence GO annotation. 360 unreviewed entries match.
  - number: 45
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000013
      curie: CATH.FunFam:3.40.50.200:FF:000013
      label: Tripeptidyl-peptidase 2 homolog
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0008236 or
      a descendant, 3 of those by a manual-evidence GO annotation. 724 unreviewed entries match.
  go_annotations:
  - go_id: GO:0008236
    go_label: serine-type peptidase activity
    aspect: MF
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 45
review_summary: >-
  All 45 live condition sets were checked against Swiss-Prot. They match 292 reviewed entries in total
  and every one carries GO:0008236 or a descendant, 225 by manual evidence. One set is wrong: set
  13 selects BMP1 and the tolloid-like proteins, which are zinc metalloproteases. They carry a serine-type
  endopeptidase term only through a Reactome TAS annotation, and the rule passes that term on to 134
  unreviewed entries. The other sets were checked by counts only.
action: MODIFY
action_rationale: >-
  Set 13 propagates a serine-type activity to zinc metalloproteases of MEROPS family M12 and should
  be removed. No defect was found in the other 44 sets. The counts are from Swiss-Prot, which is also
  what ARBA learns its rules from, so they show the condition sets are coherent rather than giving
  an independent error rate for unreviewed entries.
suggested_modifications:
- >-
  Remove condition set 13 (CATH FunFams 2.10.25.10:FF:000022 and 2.60.120.290:FF:000004 with taxon
  Haplorrhini), whose reviewed matches P13497, O43897 and Q9Y6L7 are metalloendopeptidases.
- >-
  Report upstream that the Reactome TAS annotation of GO:0004252 on P13497, O43897 and Q9Y6L7 (Reactome:R-HSA-2214330)
  is the source of the association.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0008236
  label: serine-type peptidase activity
  assessment: PARTIALLY_CORRECT
  matched_protein_count: 292
  incorrect_protein_count: 3
  incorrect_examples:
  - P13497
  - O43897
  - Q9Y6L7
  discriminating_features:
  - >-
    The reviewed matches of set 13 are members of MEROPS family M12 with a zinc cofactor, not serine
    peptidases.
  notes: >-
    Set 13: P13497 (human BMP1), UniProtKB EC 3.4.24.19, cofactor Zn(2+), MEROPS M12.005; O43897 (TLL1),
    EC 3.4.24.-, MEROPS M12.016; Q9Y6L7 (TLL2), EC 3.4.24.-, MEROPS M12.018. Each carries GO:0004222
    by IBA and carries GO:0004252 only as TAS from Reactome:R-HSA-2214330 (QuickGO, retrieved 2026-11-09).
    Set 12: the reviewed matches are Escherichia coli L,D-transpeptidases such as P0AAX8 (ybiS), annotated
    to GO:0071972 by IDA, PMID:17369299; QuickGO lists GO:0008236 among the ancestors of GO:0071972,
    so they count as carrying a descendant.
confidence: 0.7
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    The rule gives false positives for cofactor proteins such as Protein S, through CATH FunFam 4.10.740.10:FF:000001,
    and those should be excluded.
  correction: >-
    That FunFam is not in the live rule. Its CATH name is vitamin K-dependent protein S, but it is
    a Gla-domain FunFam whose members include coagulation factors VII, IX and X and protein C; a FunFam
    name is that of a representative, not a list of members.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - >-
    UniProt ARBA API, ARBA00027399, retrieved 2026-11-09: no condition on a FunFam of superfamily
    4.10.740.10.
  - >-
    CATH v4.3 API, superfamily 4.10.740.10 FunFam 1: name vitamin K-dependent protein S; seed alignment
    member descriptions include Coagulation factor X, Coagulation factor IX, Coagulation factor VII
    and Vitamin K-dependent protein C.
- date: '2026-11-10'
  withdrawn_claim: >-
    More specific child terms exist for coagulation factors, complement proteases and proprotein convertases,
    such as protein processing.
  correction: >-
    GO:0016485 is a biological process term and is not a child of the rule's molecular function term.
    The specific molecular function child that applies to most sets is GO:0004252.
  error_type: ONTOLOGY_MISREAD
  evidence:
  - >-
    QuickGO: GO:0016485 aspect biological_process; GO:0004252 has GO:0008236 as an is_a ancestor.
- date: '2026-11-10'
  withdrawn_claim: >-
    With 36 condition sets the rule is beyond what can be analysed, so overlap could not be assessed
    and the sets should be consolidated.
  correction: >-
    The number of sets is not evidence about accuracy. All 45 live sets were checked against Swiss-Prot.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - >-
    UniProtKB release 2026_04: the 45 sets match 292 reviewed entries in total, all carrying GO:0008236
    or a descendant.
- date: '2026-11-10'
  withdrawn_claim: >-
    Statements about condition sets were supported by quotations from ARBA00027399.enriched.json.
  correction: >-
    That file is not in the rule folder, so the quotations cannot be checked and are no longer cited.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    rules/arba/ARBA00027399/ contains the review, its HTML rendering, a summary and two research notes
    only.