ARBA00027624 organelle membrane (GO:0031090)

id: ARBA00027624
description: Assigns GO:0031090 organelle membrane through 472 alternative condition sets built from InterPro entries,
  PANTHER families and CATH FunFams; 107 sets carry a taxon condition.
status: IN_PROGRESS
rule_type: ARBA
rule:
  rule_id: ARBA00027624
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR050208
      curie: InterPro:IPR050208
      label: Antigen-presenting and immune regulatory MHC class I-related
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR16675:SF251
      curie: PANTHER:PTHR16675:SF251
      label: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 29. 17 carry GO:0031090 or a descendant with evidence
      other than ARBA (17 non-IEA, 0 other IEA); 12 carry it only from ARBA; 0 do not carry it. Not supported: P15978
      (RT1-Aw2 Class I histocompatibility antigen, Non-RT1.A alpha-1 chain); P13752 (BOLA class I histocompatibility
      antigen, alpha chain BL3-6); P13753 (BOLA class I histocompatibility antigen, alpha chain BL3-7); P30383 (Class
      I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain); P30387 (Class I histocompatibility antigen,
      Gogo-C*0203 alpha chain); P30386 (Class I histocompatibility antigen, Gogo-C*0202 alpha chain); and others.
      UniProtKB entries matching: 6730.'
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR003597
      curie: InterPro:IPR003597
      label: Immunoglobulin C1-set
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR007110
      curie: InterPro:IPR007110
      label: Immunoglobulin-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR010579
      curie: InterPro:IPR010579
      label: MHC class I, alpha chain, C-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 47. 16 carry GO:0031090 or a descendant with evidence
      other than ARBA (16 non-IEA, 0 other IEA); 31 carry it only from ARBA; 0 do not carry it. Not supported: P13752
      (BOLA class I histocompatibility antigen, alpha chain BL3-6); P13753 (BOLA class I histocompatibility antigen,
      alpha chain BL3-7); P13750 (Patr class I histocompatibility antigen, B-1 alpha chain); P16211 (Popy Class
      I histocompatibility antigen, A-1 alpha chain); P30379 (Class I histocompatibility antigen, Gogo-B*0101 alpha
      chain); P30388 (Class I histocompatibility antigen, Gogo-OKO alpha chain); and others. UniProtKB entries matching:
      7438.'
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR000699
      curie: InterPro:IPR000699
      label: RIH domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR005821
      curie: InterPro:IPR005821
      label: Ion transport domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry GO:0031090 or a descendant with evidence
      other than ARBA (14 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 442.'
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR000493
      curie: InterPro:IPR000493
      label: Inositol 1,4,5-trisphosphate receptor
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR013662
      curie: InterPro:IPR013662
      label: RyR/IP3R Homology associated domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry GO:0031090 or a descendant with evidence
      other than ARBA (12 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 4218.'
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR001388
      curie: InterPro:IPR001388
      label: Synaptobrevin-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR051097
      curie: InterPro:IPR051097
      label: Synaptobrevin-like vesicular transport protein
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry GO:0031090 or a descendant with evidence
      other than ARBA (11 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 4847.'
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR005024
      curie: InterPro:IPR005024
      label: Vacuolar-sorting protein SNF7-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 19. 15 carry GO:0031090 or a descendant with evidence
      other than ARBA (13 non-IEA, 2 other IEA); 4 carry it only from ARBA; 0 do not carry it. Not supported: Q4R574
      (CHMP3 Charged multivesicular body protein 3); Q5RAU5 (CHMP3 Charged multivesicular body protein 3); Q5RAV2
      (CHMP2B Charged multivesicular body protein 2b); Q5R605 (CHMP1A Charged multivesicular body protein 1a). UniProtKB
      entries matching: 691.'
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR027469
      curie: InterPro:IPR027469
      label: Cation efflux transmembrane domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry GO:0031090 or a descendant with evidence
      other than ARBA (14 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 591.'
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR002553
      curie: InterPro:IPR002553
      label: Clathrin/coatomer adaptor, adaptin-like, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR008152
      curie: InterPro:IPR008152
      label: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR017104
      curie: InterPro:IPR017104
      label: Adaptor protein complex AP-2, alpha subunit
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 14 carry GO:0031090 or a descendant with evidence
      other than ARBA (13 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 4817.'
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR004182
      curie: InterPro:IPR004182
      label: GRAM domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR011993
      curie: InterPro:IPR011993
      label: PH-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR051482
      curie: InterPro:IPR051482
      label: Membrane-anchored lipid-binding protein Aster/LAM
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry GO:0031090 or a descendant with evidence
      other than ARBA (13 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 7732.'
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR006785
      curie: InterPro:IPR006785
      label: Peroxisome membrane anchor protein Pex14/PEX33, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR025655
      curie: InterPro:IPR025655
      label: Peroxisomal membrane protein 14
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry GO:0031090 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2500.'
  - number: 11
    conditions:
    - condition_type: INTERPRO
      value: IPR007770
      curie: InterPro:IPR007770
      label: Protein DMP
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Streptophyta
      curie: NCBITaxon:35493
      label: Streptophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 9 carry GO:0031090 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 1 do not carry it. Not supported: Q3E912
      (DMP10 Protein DMP10). UniProtKB entries matching: 4533.'
  - number: 12
    conditions:
    - condition_type: INTERPRO
      value: IPR010482
      curie: InterPro:IPR010482
      label: TECPR1-like, DysF domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 13 carry GO:0031090 or a descendant with evidence
      other than ARBA (10 non-IEA, 3 other IEA); 1 carry it only from ARBA; 0 do not carry it. Not supported: O94611
      (spo73 Meiotically up-regulated gene 65 protein). UniProtKB entries matching: 3239.'
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR001503
      curie: InterPro:IPR001503
      label: Glycosyl transferase family 10
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR031481
      curie: InterPro:IPR031481
      label: Fucosyltransferase, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Hominidae
      curie: NCBITaxon:9604
      label: Hominidae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry GO:0031090 or a descendant with evidence
      other than ARBA (9 non-IEA, 9 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 71.'
  - number: 14
    conditions:
    - condition_type: INTERPRO
      value: IPR013040
      curie: InterPro:IPR013040
      label: Coatomer, gamma subunit, appendage, Ig-like subdomain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR016024
      curie: InterPro:IPR016024
      label: Armadillo-type fold
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR017106
      curie: InterPro:IPR017106
      label: Coatomer gamma subunit
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 22. 22 carry GO:0031090 or a descendant with evidence
      other than ARBA (21 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 5356.'
  - number: 15
    conditions:
    - condition_type: INTERPRO
      value: IPR031468
      curie: InterPro:IPR031468
      label: Synaptotagmin-like mitochondrial-lipid-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Saccharomycetes
      curie: NCBITaxon:4891
      label: Saccharomycetes
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 33. 33 carry GO:0031090 or a descendant with evidence
      other than ARBA (11 non-IEA, 22 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 404.'
  - number: 16
    conditions:
    - condition_type: INTERPRO
      value: IPR033122
      curie: InterPro:IPR033122
      label: LETM1-like, ribosome-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR044202
      curie: InterPro:IPR044202
      label: LETM1/MDM38-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 19. 19 carry GO:0031090 or a descendant with evidence
      other than ARBA (15 non-IEA, 4 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 9139.'
  - number: 17
    conditions:
    - condition_type: INTERPRO
      value: IPR000374
      curie: InterPro:IPR000374
      label: Phosphatidate cytidylyltransferase site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR016720
      curie: InterPro:IPR016720
      label: Phosphatidate cytidylyltransferase, eukaryota
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry GO:0031090 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 3092.'
  - number: 18
    conditions:
    - condition_type: INTERPRO
      value: IPR000648
      curie: InterPro:IPR000648
      label: Oxysterol-binding protein
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR018494
      curie: InterPro:IPR018494
      label: Oxysterol-binding protein, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: TAXON
      value: Saccharomycetales
      curie: NCBITaxon:4892
      label: Saccharomycetales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 206.'
  - number: 19
    conditions:
    - condition_type: INTERPRO
      value: IPR001611
      curie: InterPro:IPR001611
      label: Leucine-rich repeat
      interpro_type: REPEAT
      negated: false
    - condition_type: INTERPRO
      value: IPR017441
      curie: InterPro:IPR017441
      label: Protein kinase, ATP binding site
      interpro_type: BINDING_SITE
      negated: false
    - condition_type: TAXON
      value: Muroidea
      curie: NCBITaxon:337687
      label: Muroidea
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 82.'
  - number: 20
    conditions:
    - condition_type: INTERPRO
      value: IPR003280
      curie: InterPro:IPR003280
      label: Two pore domain potassium channel
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR013099
      curie: InterPro:IPR013099
      label: Potassium channel domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Embryophyta
      curie: NCBITaxon:3193
      label: Embryophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry GO:0031090 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2938.'
  - number: 21
    conditions:
    - condition_type: INTERPRO
      value: IPR003439
      curie: InterPro:IPR003439
      label: ABC transporter-like, ATP-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR050835
      curie: InterPro:IPR050835
      label: ATP-binding cassette sub-family D
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Muridae
      curie: NCBITaxon:10066
      label: Muridae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 42.'
  - number: 22
    conditions:
    - condition_type: INTERPRO
      value: IPR007657
      curie: InterPro:IPR007657
      label: Glycosyltransferase 61
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR049625
      curie: InterPro:IPR049625
      label: Glycosyltransferase 61, catalytic domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Tracheophyta
      curie: NCBITaxon:58023
      label: Tracheophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 6750.'
  - number: 23
    conditions:
    - condition_type: INTERPRO
      value: IPR011701
      curie: InterPro:IPR011701
      label: Major facilitator superfamily
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR020846
      curie: InterPro:IPR020846
      label: Major facilitator superfamily domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR23504
      curie: PANTHER:PTHR23504
      label: MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 25. 13 carry GO:0031090 or a descendant with evidence
      other than ARBA (13 non-IEA, 0 other IEA); 1 carry it only from ARBA; 11 do not carry it. Not supported: Q8NBP5
      (SLC67A2 Solute carrier family 67 member A2); Q5VZR4 (SLC71A3P Putative solute carrier family 71 member 3);
      Q3EAQ5 (ZIFL2 Probable peptide/nitrate transporter At3g43790); P39843 (blt Multidrug resistance protein 2);
      P02980 (tetA Tetracycline resistance protein, class B); P33449 (bmr Multidrug resistance protein 1); and others.
      UniProtKB entries matching: 27526.'
  - number: 24
    conditions:
    - condition_type: INTERPRO
      value: IPR009617
      curie: InterPro:IPR009617
      label: Seipin
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry GO:0031090 or a descendant with evidence
      other than ARBA (10 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 4691.'
  - number: 25
    conditions:
    - condition_type: INTERPRO
      value: IPR000163
      curie: InterPro:IPR000163
      label: Prohibitin
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR001107
      curie: InterPro:IPR001107
      label: Band 7 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry GO:0031090 or a descendant with evidence
      other than ARBA (12 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2559.'
  - number: 26
    conditions:
    - condition_type: INTERPRO
      value: IPR000245
      curie: InterPro:IPR000245
      label: V-ATPase proteolipid subunit
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR002379
      curie: InterPro:IPR002379
      label: V-ATPase proteolipid subunit C-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry GO:0031090 or a descendant with evidence
      other than ARBA (13 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 3492.'
  - number: 27
    conditions:
    - condition_type: INTERPRO
      value: IPR001079
      curie: InterPro:IPR001079
      label: Galectin, carbohydrate recognition domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR002659
      curie: InterPro:IPR002659
      label: Glycosyl transferase, family 31
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR013320
      curie: InterPro:IPR013320
      label: Concanavalin A-like lectin/glucanase domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 3393.'
  - number: 28
    conditions:
    - condition_type: INTERPRO
      value: IPR001733
      curie: InterPro:IPR001733
      label: Peptidase S26B
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR015927
      curie: InterPro:IPR015927
      label: Peptidase S24/S26A/S26B/S26C
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR019758
      curie: InterPro:IPR019758
      label: Peptidase S26A, signal peptidase I, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 24. 24 carry GO:0031090 or a descendant with evidence
      other than ARBA (24 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2509.'
  - number: 29
    conditions:
    - condition_type: INTERPRO
      value: IPR001806
      curie: InterPro:IPR001806
      label: Small GTPase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR005225
      curie: InterPro:IPR005225
      label: Small GTP-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR041840
      curie: InterPro:IPR041840
      label: Ras-related protein Rap2
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry GO:0031090 or a descendant with evidence
      other than ARBA (10 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1843.'
  - number: 30
    conditions:
    - condition_type: INTERPRO
      value: IPR002475
      curie: InterPro:IPR002475
      label: Bcl2-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR004725
      curie: InterPro:IPR004725
      label: Apoptosis regulator, Bcl-2/ BclX
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 130.'
  - number: 31
    conditions:
    - condition_type: INTERPRO
      value: IPR004835
      curie: InterPro:IPR004835
      label: Chitin synthase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR029044
      curie: InterPro:IPR029044
      label: Nucleotide-diphospho-sugar transferases
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Ustilaginomycotina
      curie: NCBITaxon:452284
      label: Ustilaginomycotina
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 346.'
  - number: 32
    conditions:
    - condition_type: INTERPRO
      value: IPR005336
      curie: InterPro:IPR005336
      label: Mitochondrial pyruvate carrier
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR14154
      curie: PANTHER:PTHR14154
      label: UPF0041 BRAIN PROTEIN 44-RELATED
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry GO:0031090 or a descendant with evidence
      other than ARBA (10 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1963.'
  - number: 33
    conditions:
    - condition_type: INTERPRO
      value: IPR007379
      curie: InterPro:IPR007379
      label: Tim44-like domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR032710
      curie: InterPro:IPR032710
      label: NTF2-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR039544
      curie: InterPro:IPR039544
      label: Tim44-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry GO:0031090 or a descendant with evidence
      other than ARBA (8 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 6258.'
  - number: 34
    conditions:
    - condition_type: INTERPRO
      value: IPR011012
      curie: InterPro:IPR011012
      label: Longin-like domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR022775
      curie: InterPro:IPR022775
      label: AP complex, mu/sigma subunit
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Saccharomyces
      curie: NCBITaxon:4930
      label: Saccharomyces
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 63.'
  - number: 35
    conditions:
    - condition_type: INTERPRO
      value: IPR018967
      curie: InterPro:IPR018967
      label: Iron-binding zinc finger, CDGSH type
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR019610
      curie: InterPro:IPR019610
      label: Iron sulphur domain-containing, mitoNEET, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR042216
      curie: InterPro:IPR042216
      label: MitoNEET, CDGSH iron-sulfur domain
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 31. 31 carry GO:0031090 or a descendant with evidence
      other than ARBA (20 non-IEA, 11 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1892.'
  - number: 36
    conditions:
    - condition_type: INTERPRO
      value: IPR027027
      curie: InterPro:IPR027027
      label: GOSR2/Membrin/Bos1
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR21230
      curie: PANTHER:PTHR21230
      label: VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1466.'
  - number: 37
    conditions:
    - condition_type: INTERPRO
      value: IPR027417
      curie: InterPro:IPR027417
      label: P-loop containing nucleoside triphosphate hydrolase
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050209
      curie: InterPro:IPR050209
      label: Membrane trafficking Rab GTPase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Rattus
      curie: NCBITaxon:10114
      label: Rattus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 1 carry it only from ARBA; 0 do not carry it. Not supported: Q5M7U5
      (Rab19 Ras-related protein Rab-19). UniProtKB entries matching: 44.'
  - number: 38
    conditions:
    - condition_type: INTERPRO
      value: IPR036280
      curie: InterPro:IPR036280
      label: Multiheme cytochrome superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR040963
      curie: InterPro:IPR040963
      label: Magnetochrome domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 42.'
  - number: 39
    conditions:
    - condition_type: INTERPRO
      value: IPR000547
      curie: InterPro:IPR000547
      label: Clathrin, heavy chain/VPS, 7-fold repeat
      interpro_type: REPEAT
      negated: false
    - condition_type: TAXON
      value: Saccharomycotina
      curie: NCBITaxon:147537
      label: Saccharomycotina
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 588.'
  - number: 40
    conditions:
    - condition_type: INTERPRO
      value: IPR060722
      curie: InterPro:IPR060722
      label: Magnetosome protein MamG/MamD-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry GO:0031090 or a descendant with evidence
      other than ARBA (8 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 45.'
  - number: 41
    conditions:
    - condition_type: INTERPRO
      value: IPR029008
      curie: InterPro:IPR029008
      label: ER membrane protein complex subunit 6-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry GO:0031090 or a descendant with evidence
      other than ARBA (12 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 5380.'
  - number: 42
    conditions:
    - condition_type: PANTHER
      value: PTHR13533
      curie: PANTHER:PTHR13533
      label: N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 14. 8 carry GO:0031090 or a descendant with evidence
      other than ARBA (8 non-IEA, 0 other IEA); 0 carry it only from ARBA; 6 do not carry it. Not supported: F4K5L5
      (TBL16 Protein trichome birefringence-like 16); P0CM56 (CAS1 Probable O-acetyltransferase CAS1); O80940 (TBL15
      Protein trichome birefringence-like 15); Q0WPS0 (TBL14 Protein trichome birefringence-like 14); P0CM57 (CAS1
      Probable O-acetyltransferase CAS1); Q8X226 (CAS1 Probable O-acetyltransferase CAS1). UniProtKB entries matching:
      5864.'
  - number: 43
    conditions:
    - condition_type: INTERPRO
      value: IPR000008
      curie: InterPro:IPR000008
      label: C2 domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR017147
      curie: InterPro:IPR017147
      label: Tricalbin
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR035892
      curie: InterPro:IPR035892
      label: C2 domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0031090 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1597.'
  - number: 44
    conditions:
    - condition_type: INTERPRO
      value: IPR000425
      curie: InterPro:IPR000425
      label: Major intrinsic protein
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR023271
      curie: InterPro:IPR023271
      label: Aquaporin-like
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR45665:SF9
      curie: PANTHER:PTHR45665:SF9
      label: AQUAPORIN-8
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1763.'
  - number: 45
    conditions:
    - condition_type: INTERPRO
      value: IPR000644
      curie: InterPro:IPR000644
      label: CBS domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR051280
      curie: InterPro:IPR051280
      label: Voltage-gated chloride channel/antiporter
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 681.'
  - number: 46
    conditions:
    - condition_type: INTERPRO
      value: IPR000727
      curie: InterPro:IPR000727
      label: Target SNARE coiled-coil homology domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006012
      curie: InterPro:IPR006012
      label: Syntaxin/epimorphin, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR015260
      curie: InterPro:IPR015260
      label: Syntaxin 6/10/61, N-terminal
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1417.'
  - number: 47
    conditions:
    - condition_type: INTERPRO
      value: IPR000849
      curie: InterPro:IPR000849
      label: Sugar phosphate transporter
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036259
      curie: InterPro:IPR036259
      label: MFS transporter superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Eutheria
      curie: NCBITaxon:9347
      label: Eutheria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry GO:0031090 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1141.'
  - number: 48
    conditions:
    - condition_type: INTERPRO
      value: IPR001356
      curie: InterPro:IPR001356
      label: Homeodomain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006634
      curie: InterPro:IPR006634
      label: TRAM/LAG1/CLN8 homology domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Mus
      curie: NCBITaxon:10088
      label: Mus
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0031090 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 30.'
  - number: 49
    conditions:
    - condition_type: INTERPRO
      value: IPR001433
      curie: InterPro:IPR001433
      label: Oxidoreductase FAD/NAD(P)-binding
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR001709
      curie: InterPro:IPR001709
      label: Flavoprotein pyridine nucleotide cytochrome reductase
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: BOP clade
      curie: NCBITaxon:359160
      label: BOP clade
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 7 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 2 carry it only from ARBA; 4 do not carry it. Not supported: P27968
      (NAR-7 Nitrate reductase [NAD(P)H]); P16081 (NIA1 Nitrate reductase [NADH] 1); P41345 (Ferredoxin--NADP reductase,
      root isozyme, chloroplastic); P27969 (Nitrate reductase [NADH]); P27967 (Nitrate reductase [NADH]); O23877
      (Ferredoxin--NADP reductase, embryo isozyme, chloroplastic). UniProtKB entries matching: 529.'
  - number: 50
    conditions:
    - condition_type: INTERPRO
      value: IPR001461
      curie: InterPro:IPR001461
      label: Aspartic peptidase A1
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR001969
      curie: InterPro:IPR001969
      label: Aspartic peptidase, active site
      interpro_type: ACTIVE_SITE
      negated: false
    - condition_type: PANTHER
      value: PTHR13683:SF375
      curie: PANTHER:PTHR13683:SF375
      label: PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0031090 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 306.'
  - number: 51
    conditions:
    - condition_type: INTERPRO
      value: IPR001623
      curie: InterPro:IPR001623
      label: DnaJ domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR018253
      curie: InterPro:IPR018253
      label: DnaJ domain, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR051100
      curie: InterPro:IPR051100
      label: DnaJ subfamily B/C chaperone co-factors
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 20. 20 carry GO:0031090 or a descendant with evidence
      other than ARBA (18 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 5234.'
  - number: 52
    conditions:
    - condition_type: INTERPRO
      value: IPR004713
      curie: InterPro:IPR004713
      label: Calcium/proton exchanger
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR004837
      curie: InterPro:IPR004837
      label: Sodium/calcium exchanger membrane region
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Spermatophyta
      curie: NCBITaxon:58024
      label: Spermatophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 13 carry GO:0031090 or a descendant with evidence
      other than ARBA (13 non-IEA, 0 other IEA); 2 carry it only from ARBA; 0 do not carry it. Not supported: Q5QNI2
      (NCL1 Sodium/calcium exchanger NCL1); Q6K3R5 (NCL2 Sodium/calcium exchanger NCL2). UniProtKB entries matching:
      5049.'
  - number: 53
    conditions:
    - condition_type: INTERPRO
      value: IPR006153
      curie: InterPro:IPR006153
      label: Cation/H+ exchanger, transmembrane domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR038770
      curie: InterPro:IPR038770
      label: Sodium/solute symporter superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR045158
      curie: InterPro:IPR045158
      label: K(+) efflux antiporter 4/5/6-like
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0031090 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 3493.'
  - number: 54
    conditions:
    - condition_type: INTERPRO
      value: IPR006769
      curie: InterPro:IPR006769
      label: Calcium uniporter protein, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR039055
      curie: InterPro:IPR039055
      label: MCU family
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Pezizomycotina
      curie: NCBITaxon:147538
      label: Pezizomycotina
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0031090 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 777.'
  - number: 55
    conditions:
    - condition_type: INTERPRO
      value: IPR006925
      curie: InterPro:IPR006925
      label: Vps16, C-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR006926
      curie: InterPro:IPR006926
      label: Vps16, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR038132
      curie: InterPro:IPR038132
      label: Vps16, C-terminal domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry GO:0031090 or a descendant with evidence
      other than ARBA (7 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 3602.'
  - number: 56
    conditions:
    - condition_type: INTERPRO
      value: IPR007705
      curie: InterPro:IPR007705
      label: Vesicle transport v-SNARE, N-terminal
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR010989
      curie: InterPro:IPR010989
      label: SNARE
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR21230:SF26
      curie: PANTHER:PTHR21230:SF26
      label: VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 4264.'
  - number: 57
    conditions:
    - condition_type: INTERPRO
      value: IPR008733
      curie: InterPro:IPR008733
      label: Peroxisomal biogenesis factor 11
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR12652
      curie: PANTHER:PTHR12652
      label: PEROXISOMAL BIOGENESIS FACTOR 11
      negated: false
    - condition_type: TAXON
      value: Magnoliopsida
      curie: NCBITaxon:3398
      label: Magnoliopsida
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 12 carry GO:0031090 or a descendant with evidence
      other than ARBA (10 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1833.'
  - number: 58
    conditions:
    - condition_type: INTERPRO
      value: IPR010908
      curie: InterPro:IPR010908
      label: Longin domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR042855
      curie: InterPro:IPR042855
      label: v-SNARE, coiled-coil homology domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR044565
      curie: InterPro:IPR044565
      label: Vesicle-trafficking protein Sec22
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 18 carry GO:0031090 or a descendant with evidence
      other than ARBA (15 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 4080.'
  - number: 59
    conditions:
    - condition_type: INTERPRO
      value: IPR011004
      curie: InterPro:IPR011004
      label: Trimeric LpxA-like superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR047324
      curie: InterPro:IPR047324
      label: Gamma carbonic anhydrase-like
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: eudicotyledons
      curie: NCBITaxon:71240
      label: eudicotyledons
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0031090 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1303.'
  - number: 60
    conditions:
    - condition_type: INTERPRO
      value: IPR012493
      curie: InterPro:IPR012493
      label: Renin receptor-like
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR056780
      curie: InterPro:IPR056780
      label: Renin receptor-like, C-terminal transmembrane spanning segment
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR057318
      curie: InterPro:IPR057318
      label: Renin receptor, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0031090 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1675.'
  go_annotations:
  - go_id: GO:0031090
    go_label: organelle membrane
    aspect: CC
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 472
review_summary: The first 60 of 472 live condition sets (CS1 to CS60) were queried; the other 412 were not examined.
  Each set was turned into a UniProtKB query and its Swiss-Prot matches were inspected on 2026-11-09. A match counts
  as supported when it carries the term or an is_a/part_of descendant with evidence other than ARBA; annotations
  placed by ARBA rules on Swiss-Prot entries were not counted. Of the 60, 50 are fully supported, 10 partly, 0 have
  reviewed matches but none supported, and 0 have no reviewed match. With most of the rule unexamined, no verdict
  is given. UniProt reports zero proteins for the rule and QuickGO lists no annotation attributed to it.
action: UNDECIDED
action_rationale: Only 60 of 472 condition sets were examined, and the unsupported matches among them were not adjudicated
  individually.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0031090
  label: organelle membrane
  assessment: UNDECIDED
  notes: '60 of 472 sets examined; per-set Swiss-Prot support is in rule.condition_sets notes. Partly supported
    sets: CS1, CS2, CS6, CS11, CS12, CS23, CS37, CS42, CS49, CS52. Unsupported sets: none. Sets without reviewed
    matches: none.'
corrections:
- date: '2026-11-10'
  withdrawn_claim: The rule should be deprecated because 304 condition sets are 25 times a recommended maximum of
    12.
  correction: Set count is not evidence about any annotation.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'Live rule: 472 condition sets (2026-11-09)'
- date: '2026-11-10'
  withdrawn_claim: GO:0031090 is too general to use, and grouping membranes of organelles with different targeting
    mechanisms is incoherent and contradicted by the literature.
  correction: GO:0031090 is a valid grouping term for the membrane of any organelle; a protein of the mitochondrial,
    ER or nuclear membrane is correctly described by it. How proteins reach different organelles has no bearing
    on whether the term is true. No publication was cited.
  error_type: GENERAL_IS_NOT_WRONG
  evidence:
  - 'QuickGO GO:0031090: organelle membrane, not obsolete; 332 is_a/part_of descendants'
- date: '2026-11-10'
  withdrawn_claim: 67% of condition sets contain a single FunFam, which indicates promiscuous annotation and false
    positives.
  correction: A FunFam is a narrow functional family; a single-FunFam condition is not evidence of imprecision,
    and no false positive was shown.
  error_type: UNEXAMINED_RULE
  evidence:
  - 'Earlier version of this file: condition_sets empty, protein counts 0'
- date: '2026-11-10'
  withdrawn_claim: Organelle targeting mechanisms evolved independently and are not conserved across broad taxa,
    so the taxonomic scope is too broad.
  correction: This was asserted without a source and does not bear on a cellular component annotation. The taxon
    conditions restrict individual sets.
  error_type: TAXON_MISREAD
  evidence:
  - 'Live rule: 107 of 472 sets carry a taxon condition'
- date: '2026-11-10'
  withdrawn_claim: GO curators have raised concerns about such rules in the issue tracker, and GO guidelines recommend
    against GO:0031090.
  correction: No issue or guideline was cited.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - Earlier version of this file cited only its own notes file