ARBA00027853 isoprenoid metabolic process (GO:0006720)

id: ARBA00027853
description: Assigns GO:0006720 isoprenoid metabolic process through 89 alternative condition sets built from InterPro
  entries, PANTHER families and CATH FunFams, 70 of them with a taxon condition. The sets cover terpene synthases
  and cyclases, prenyl diphosphate synthases, carotenoid synthesis and cleavage enzymes, gibberellin and abscisic
  acid oxidases, mevalonate pathway enzymes and retinoid-metabolising enzymes.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00027853
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR002060
      curie: InterPro:IPR002060
      label: Squalene/phytoene synthase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR008949
      curie: InterPro:IPR008949
      label: Isoprenoid synthase domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR31480
      curie: PANTHER:PTHR31480
      label: BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 66. 55 carry GO:0006720 or a descendant with evidence
      other than ARBA (44 non-IEA, 11 other IEA); 10 carry it only from ARBA; 1 do not carry it. Not supported:
      A9JQL9 (crtM 4,4''-diapophytoene synthase); O07854 (crtM 4,4''-diapophytoene synthase); Q54E48 (NADH dehydrogenase
      (ubiquinone) complex I, assembly factor 6 homolog); Q2YWE7 (crtM 4,4''-diapophytoene synthase); Q4L976 (crtM
      4,4''-diapophytoene synthase); Q6G6B2 (crtM 4,4''-diapophytoene synthase); and others. UniProtKB entries matching:
      18893.'
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR001906
      curie: InterPro:IPR001906
      label: Terpene synthase, N-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: PANTHER
      value: PTHR31225:SF93
      curie: PANTHER:PTHR31225:SF93
      label: ALPHA-HUMULENE_(-)-(E)-BETA-CARYOPHYLLENE SYNTHASE
      negated: false
    - condition_type: TAXON
      value: asterids
      curie: NCBITaxon:71274
      label: asterids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 25. 25 carry GO:0006720 or a descendant with evidence
      other than ARBA (19 non-IEA, 6 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 486.'
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR008930
      curie: InterPro:IPR008930
      label: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036965
      curie: InterPro:IPR036965
      label: Terpene synthase, N-terminal domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: TAXON
      value: Isodoninae
      curie: NCBITaxon:2836344
      label: Isodoninae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 21. 21 carry GO:0006720 or a descendant with evidence
      other than ARBA (19 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 31.'
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR004294
      curie: InterPro:IPR004294
      label: Carotenoid oxygenase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 23 carry GO:0006720 or a descendant with evidence
      other than ARBA (22 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 6444.'
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR001128
      curie: InterPro:IPR001128
      label: Cytochrome P450
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR47955
      curie: PANTHER:PTHR47955
      label: CYTOCHROME P450 FAMILY 71 PROTEIN
      negated: false
    - condition_type: TAXON
      value: Asterales
      curie: NCBITaxon:4209
      label: Asterales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 18. 16 carry GO:0006720 or a descendant with evidence
      other than ARBA (14 non-IEA, 2 other IEA); 2 carry it only from ARBA; 0 do not carry it. Not supported: E1B2Z9
      (CYP71AV8 Cytochrome P450 71AV8); G3GBK0 (CYP71BL3 Costunolide synthase). UniProtKB entries matching: 1208.'
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR005630
      curie: InterPro:IPR005630
      label: Terpene synthase-like, metal-binding domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR034741
      curie: InterPro:IPR034741
      label: Terpene cyclase-like 1, C-terminal domain
      interpro_type: DOMAIN
      negated: false
    - condition_type: TAXON
      value: Lavandulinae
      curie: NCBITaxon:2836342
      label: Lavandulinae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry GO:0006720 or a descendant with evidence
      other than ARBA (12 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 28.'
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR002401
      curie: InterPro:IPR002401
      label: Cytochrome P450, E-class, group I
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR017972
      curie: InterPro:IPR017972
      label: Cytochrome P450, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: PANTHER
      value: PTHR24286:SF384
      curie: PANTHER:PTHR24286:SF384
      label: P450, PUTATIVE (EUROFUNG)-RELATED
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 12. 9 carry GO:0006720 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 3 do not carry it. Not supported: Q50EK1
      (CYP716B1 Cytochrome P450 716B1); Q59990 (cyp120 Putative cytochrome P450 120); Q50EK0 (CYP716B2 Cytochrome
      P450 716B2). UniProtKB entries matching: 571.'
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR036396
      curie: InterPro:IPR036396
      label: Cytochrome P450 superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR47950:SF4
      curie: PANTHER:PTHR47950:SF4
      label: GERANIOL 8-HYDROXYLASE-LIKE
      negated: false
    - condition_type: TAXON
      value: Nepetoideae
      curie: NCBITaxon:216706
      label: Nepetoideae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry GO:0006720 or a descendant with evidence
      other than ARBA (9 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 109.'
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR017825
      curie: InterPro:IPR017825
      label: Lycopene cyclase domain
      interpro_type: DOMAIN
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 21 carry GO:0006720 or a descendant with evidence
      other than ARBA (21 non-IEA, 0 other IEA); 2 carry it only from ARBA; 0 do not carry it. Not supported: A1XI30
      (lbtBC C(50) beta-cyclic carotenoids biosynthesis protein LbtBC); A1XI29 (lbtA Putative C(50) carotenoid beta-cyclase
      subunit A). UniProtKB entries matching: 5141.'
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR000092
      curie: InterPro:IPR000092
      label: Polyprenyl synthetase-like
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR12001
      curie: PANTHER:PTHR12001
      label: GERANYLGERANYL PYROPHOSPHATE SYNTHASE
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry GO:0006720 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2958.'
  - number: 11
    conditions:
    - condition_type: PANTHER
      value: PTHR31225:SF9
      curie: PANTHER:PTHR31225:SF9
      label: TERPENE SYNTHASE 10
      negated: false
    - condition_type: TAXON
      value: Elsholtzieae
      curie: NCBITaxon:216720
      label: Elsholtzieae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0006720 or a descendant with evidence
      other than ARBA (7 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 24.'
  - number: 12
    conditions:
    - condition_type: INTERPRO
      value: IPR002937
      curie: InterPro:IPR002937
      label: Amine oxidase
      interpro_type: DOMAIN
      negated: false
    - condition_type: INTERPRO
      value: IPR008150
      curie: InterPro:IPR008150
      label: Phytoene dehydrogenase, bacterial-type, conserved site
      interpro_type: CONSERVED_SITE
      negated: false
    - condition_type: INTERPRO
      value: IPR014105
      curie: InterPro:IPR014105
      label: Carotenoid/retinoid oxidoreductase
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 16 carry GO:0006720 or a descendant with evidence
      other than ARBA (6 non-IEA, 10 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 3333.'
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR002213
      curie: InterPro:IPR002213
      label: UDP-glucuronosyl/UDP-glucosyltransferase
      interpro_type: FAMILY
      negated: false
    - condition_type: TAXON
      value: Caryophyllaceae
      curie: NCBITaxon:3568
      label: Caryophyllaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0006720 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 246.'
  - number: 14
    conditions:
    - condition_type: PANTHER
      value: PTHR31225:SF98
      curie: PANTHER:PTHR31225:SF98
      label: TERPENE SYNTHASE 9-RELATED
      negated: false
    - condition_type: TAXON
      value: Pinopsida
      curie: NCBITaxon:58019
      label: Pinopsida
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0006720 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 9.'
  - number: 15
    conditions:
    - condition_type: INTERPRO
      value: IPR014102
      curie: InterPro:IPR014102
      label: Phytoene desaturase
      interpro_type: FAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR036188
      curie: InterPro:IPR036188
      label: FAD/NAD(P)-binding domain superfamily
      interpro_type: HOMOLOGOUS_SUPERFAMILY
      negated: false
    - condition_type: INTERPRO
      value: IPR050464
      curie: InterPro:IPR050464
      label: Zeta Carotene Desaturase and Related Oxidoreductases
      interpro_type: FAMILY
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 11 carry GO:0006720 or a descendant with evidence
      other than ARBA (9 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1048.'
  - number: 16
    conditions:
    - condition_type: INTERPRO
      value: IPR039702
      curie: InterPro:IPR039702
      label: Farnesyl pyrophosphate synthase-like
      interpro_type: FAMILY
      negated: false
    - condition_type: PANTHER
      value: PTHR11525:SF0
      curie: PANTHER:PTHR11525:SF0
      label: FARNESYL PYROPHOSPHATE SYNTHASE
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1308.'
  - number: 17
    conditions:
    - condition_type: PANTHER
      value: PTHR31739:SF25
      curie: PANTHER:PTHR31739:SF25
      label: (E,E)-GERANYLLINALOOL SYNTHASE
      negated: false
    - condition_type: TAXON
      value: Picea
      curie: NCBITaxon:3328
      label: Picea
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 8. 8 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 31.'
  - number: 18
    conditions:
    - condition_type: PANTHER
      value: PTHR43734
      curie: PANTHER:PTHR43734
      label: PHYTOENE DESATURASE
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 22. 14 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 9 other IEA); 0 carry it only from ARBA; 8 do not carry it. Not supported: Q8ZAH6
      (glpB Anaerobic glycerol-3-phosphate dehydrogenase subunit B); A1JIB0 (glpB Anaerobic glycerol-3-phosphate
      dehydrogenase subunit B); Q1CNF8 (glpB Anaerobic glycerol-3-phosphate dehydrogenase subunit B); Q6CZI7 (glpB
      Anaerobic glycerol-3-phosphate dehydrogenase subunit B); Q1CBK6 (glpB Anaerobic glycerol-3-phosphate dehydrogenase
      subunit B); A4WCP1 (glpB Anaerobic glycerol-3-phosphate dehydrogenase subunit B); and others. UniProtKB entries
      matching: 6302. The 8 unsupported entries are all GlpB, the B subunit of anaerobic glycerol-3-phosphate dehydrogenase
      (EC 1.1.5.3, HAMAP MF_00753), which PANTHER places in family PTHR43734. 275 UniProtKB entries with gene name
      glpB match this set.'
  - number: 19
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000005
      curie: CATH.FunFam:1.10.600.10:FF:000005
      label: Ent-kaur-16-ene synthase, chloroplastic
      negated: false
    - condition_type: FUNFAM
      value: 1.50.10.130:FF:000004
      curie: CATH.FunFam:1.50.10.130:FF:000004
      label: Carene synthase, chloroplastic
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 35. 35 carry GO:0006720 or a descendant with evidence
      other than ARBA (32 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 53.'
  - number: 20
    conditions:
    - condition_type: FUNFAM
      value: 1.50.10.130:FF:000002
      curie: CATH.FunFam:1.50.10.130:FF:000002
      label: Ent-copalyl diphosphate synthase, chloroplastic
      negated: false
    - condition_type: TAXON
      value: Ocimeae
      curie: NCBITaxon:216719
      label: Ocimeae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 17. 17 carry GO:0006720 or a descendant with evidence
      other than ARBA (15 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 30.'
  - number: 21
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000007
      curie: CATH.FunFam:1.10.600.10:FF:000007
      label: Isoprene synthase, chloroplastic
      negated: false
    - condition_type: TAXON
      value: Lavandulinae
      curie: NCBITaxon:2836342
      label: Lavandulinae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 15. 15 carry GO:0006720 or a descendant with evidence
      other than ARBA (12 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 27.'
  - number: 22
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000043
      curie: CATH.FunFam:1.10.630.10:FF:000043
      label: Cytochrome P450 99A2
      negated: false
    - condition_type: TAXON
      value: campanulids
      curie: NCBITaxon:91882
      label: campanulids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 16. 12 carry GO:0006720 or a descendant with evidence
      other than ARBA (11 non-IEA, 1 other IEA); 4 carry it only from ARBA; 0 do not carry it. Not supported: E1B2Z9
      (CYP71AV8 Cytochrome P450 71AV8); G3GBK0 (CYP71BL3 Costunolide synthase); H2DH20 (Cytochrome P450 CYP71D313);
      H2DH19 (Cytochrome P450 CYP71D312). UniProtKB entries matching: 385.'
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000004
      curie: CATH.FunFam:1.10.600.10:FF:000004
      label: Phytoene synthase chloroplastic
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 17. 17 carry GO:0006720 or a descendant with evidence
      other than ARBA (12 non-IEA, 5 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1966.'
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000007
      curie: CATH.FunFam:1.10.630.10:FF:000007
      label: Cytochrome P450 76C4
      negated: false
    - condition_type: TAXON
      value: Nepetoideae
      curie: NCBITaxon:216706
      label: Nepetoideae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry GO:0006720 or a descendant with evidence
      other than ARBA (8 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 70.'
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.330:FF:000003
      curie: CATH.FunFam:2.60.120.330:FF:000003
      label: Gibberellin 20 oxidase 2
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 11. 10 carry GO:0006720 or a descendant with evidence
      other than ARBA (10 non-IEA, 0 other IEA); 1 carry it only from ARBA; 0 do not carry it. Not supported: P0C5H5
      (20ox2 Gibberellin 20 oxidase 2). UniProtKB entries matching: 2504.'
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.330:FF:000013
      curie: CATH.FunFam:2.60.120.330:FF:000013
      label: Gibberellin 3-beta-dioxygenase 1
      negated: false
    - condition_type: TAXON
      value: Streptophyta
      curie: NCBITaxon:35493
      label: Streptophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 10 carry GO:0006720 or a descendant with evidence
      other than ARBA (10 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1231.'
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000020
      curie: CATH.FunFam:1.10.600.10:FF:000020
      label: Phytoene synthase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 13. 13 carry GO:0006720 or a descendant with evidence
      other than ARBA (13 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2066.'
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.330:FF:000014
      curie: CATH.FunFam:2.60.120.330:FF:000014
      label: Gibberellin 2-beta-dioxygenase 1
      negated: false
    - condition_type: TAXON
      value: Embryophyta
      curie: NCBITaxon:3193
      label: Embryophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1554.'
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000091
      curie: CATH.FunFam:3.50.50.60:FF:000091
      label: 15-cis-phytoene desaturase, chloroplastic/chromoplastic
      negated: false
    - condition_type: TAXON
      value: Tracheophyta
      curie: NCBITaxon:58023
      label: Tracheophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 9 carry GO:0006720 or a descendant with evidence
      other than ARBA (9 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 652.'
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 1.10.3270.10:FF:000002
      curie: CATH.FunFam:1.10.3270.10:FF:000002
      label: 3-hydroxy-3-methylglutaryl coenzyme A reductase
      negated: false
    - condition_type: FUNFAM
      value: 3.90.770.10:FF:000001
      curie: CATH.FunFam:3.90.770.10:FF:000001
      label: 3-hydroxy-3-methylglutaryl coenzyme A reductase
      negated: false
    - condition_type: TAXON
      value: Spermatophyta
      curie: NCBITaxon:58024
      label: Spermatophyta
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 23. 18 carry GO:0006720 or a descendant with evidence
      other than ARBA (13 non-IEA, 5 other IEA); 5 carry it only from ARBA; 0 do not carry it. Not supported: Q01559
      (HMGR 3-hydroxy-3-methylglutaryl-coenzyme A reductase); Q03163 (HMGR 3-hydroxy-3-methylglutaryl-coenzyme A
      reductase); Q9XEL8 (HMGR2 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2); P48021 (3-hydroxy-3-methylglutaryl-coenzyme
      A reductase); U5JCC6 (HMGR2 3-hydroxy-3-methylglutaryl coenzyme A reductase 2-B). UniProtKB entries matching:
      1690.'
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000024
      curie: CATH.FunFam:1.10.600.10:FF:000024
      label: Ent-copalyl diphosphate synthase
      negated: false
    - condition_type: FUNFAM
      value: 1.50.10.160:FF:000001
      curie: CATH.FunFam:1.50.10.160:FF:000001
      label: Ent-copalyl diphosphate synthase
      negated: false
    - condition_type: TAXON
      value: Magnoliopsida
      curie: NCBITaxon:3398
      label: Magnoliopsida
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 39.'
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 1.50.10.20:FF:000011
      curie: CATH.FunFam:1.50.10.20:FF:000011
      label: Terpene cyclase/mutase family member
      negated: false
    - condition_type: FUNFAM
      value: 1.50.10.20:FF:000044
      curie: CATH.FunFam:1.50.10.20:FF:000044
      label: Lupeol synthase
      negated: false
    - condition_type: TAXON
      value: fabids
      curie: NCBITaxon:91835
      label: fabids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 192.'
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000008
      curie: CATH.FunFam:1.10.630.10:FF:000008
      label: Cytochrome P450 71D8
      negated: false
    - condition_type: TAXON
      value: Liliopsida
      curie: NCBITaxon:4447
      label: Liliopsida
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 591.'
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000041
      curie: CATH.FunFam:1.10.630.10:FF:000041
      label: Cytochrome P450 26A1 isoform 1
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 807.'
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000299
      curie: CATH.FunFam:1.10.630.10:FF:000299
      label: Cytochrome P450 2C9
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 1 carry it only from ARBA; 0 do not carry it. Not supported: P33262
      (CYP2C20 Cytochrome P450 2C20). UniProtKB entries matching: 250. Matches include CYP2C9 (P11712, monoterpenoid
      metabolic process GO:0016098 by IDA, PMID:16401082).'
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 1.50.10.20:FF:000064
      curie: CATH.FunFam:1.50.10.20:FF:000064
      label: Uncharacterized protein
      negated: false
    - condition_type: TAXON
      value: Saxifragales
      curie: NCBITaxon:41946
      label: Saxifragales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 10.'
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000808
      curie: CATH.FunFam:3.40.50.720:FF:000808
      label: Iridoid synthase
      negated: false
    - condition_type: TAXON
      value: asterids
      curie: NCBITaxon:71274
      label: asterids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 9. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 5 carry it only from ARBA; 0 do not carry it. Not supported: Q6PQJ9
      (3-oxo-Delta(4,5)-steroid 5-beta-reductase); A0A221J5X6 (ISY2 (S)-8-oxocitronellyl enol synthase ISY2); A0A221J5W8
      (ISY1 (S)-8-oxocitronellyl enol synthase ISY1); A0A221J5X1 (ISY2 (S)-8-oxocitronellyl enol synthase ISY2);
      A0A221J5X3 (ISY1 (S)-8-oxocitronellyl enol synthase ISY1). UniProtKB entries matching: 396. Q6PQJ9 carries
      the term only as IEA GO_REF:0000117 from this rule.'
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 3.30.230.10:FF:000018
      curie: CATH.FunFam:3.30.230.10:FF:000018
      label: Diphosphomevalonate decarboxylase
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.890:FF:000005
      curie: CATH.FunFam:3.30.70.890:FF:000005
      label: Diphosphomevalonate decarboxylase
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 181.'
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 3.30.230.10:FF:000027
      curie: CATH.FunFam:3.30.230.10:FF:000027
      label: Mevalonate kinase
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.890:FF:000003
      curie: CATH.FunFam:3.30.70.890:FF:000003
      label: Mevalonate kinase
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 572.'
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000110
      curie: CATH.FunFam:3.40.50.1820:FF:000110
      label: Hormone-sensitive lipase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000199
      curie: CATH.FunFam:3.40.50.1820:FF:000199
      label: Hormone-sensitive lipase
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0006720 or a descendant with evidence
      other than ARBA (6 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 90. Matches are hormone-sensitive lipase LIPE (human Q05469, retinyl-palmitate esterase activity
      GO:0050253 by IDA, PMID:15955102).'
  - number: 41
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:001857
      curie: CATH.FunFam:3.40.50.720:FF:001857
      label: Alcohol dehydrogenase class 4 mu/sigma chain
      negated: false
    - condition_type: FUNFAM
      value: 3.90.180.10:FF:000067
      curie: CATH.FunFam:3.90.180.10:FF:000067
      label: alcohol dehydrogenase 1-like isoform X1
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 4 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 216. Matches include ADH7 (human P40394, retinoid metabolic process GO:0001523 by IDA, PMID:16787387
      and PMID:9600267).'
  - number: 42
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000001
      curie: CATH.FunFam:1.10.600.10:FF:000001
      label: Geranylgeranyl diphosphate synthase
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 10. 5 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 0 other IEA); 5 carry it only from ARBA; 0 do not carry it. Not supported: P45204
      (ispA Farnesyl diphosphate synthase); P55539 (Probable farnesyl diphosphate synthase); Q8K9A0 (ispA Farnesyl
      diphosphate synthase); P57537 (ispA Farnesyl diphosphate synthase); Q45220 (fppS Probable farnesyl diphosphate
      synthase). UniProtKB entries matching: 8341.'
  - number: 43
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000009
      curie: CATH.FunFam:1.10.600.10:FF:000009
      label: Geranylgeranyl pyrophosphate synthase
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 875.'
  - number: 44
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000018
      curie: CATH.FunFam:1.10.600.10:FF:000018
      label: Probable geranylgeranyl-diphosphate geranylgeranyltransferase (AL-2)
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 78.'
  - number: 45
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000019
      curie: CATH.FunFam:1.10.600.10:FF:000019
      label: 2-methylisoborneol synthase
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 235.'
  - number: 46
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.150:FF:000183
      curie: CATH.FunFam:3.40.50.150:FF:000183
      label: Geranyl diphosphate 2-C-methyltransferase
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 267.'
  - number: 47
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000084
      curie: CATH.FunFam:3.40.50.720:FF:000084
      label: Short-chain dehydrogenase reductase
      negated: false
    - condition_type: TAXON
      value: Lamiaceae
      curie: NCBITaxon:4136
      label: Lamiaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 3 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 0 other IEA); 4 carry it only from ARBA; 0 do not carry it. Not supported: A0A3Q8GL18
      (NEPS1 (+)-cis,trans-nepetalactol synthase NEPS1); A0A3Q8GLE8 (NEPS3 (+)-cis,cis-nepetalactol synthase NEPS3);
      K4N0V2 (BDH Borneol dehydrogenase, mitochondrial); A0A3Q8GYY4 (NEPS2 (+)-cis,trans-nepetalactol synthase NEPS2).
      UniProtKB entries matching: 144.'
  - number: 48
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000145
      curie: CATH.FunFam:3.40.50.720:FF:000145
      label: Retinol dehydrogenase 12
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 109.'
  - number: 49
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.920:FF:000002
      curie: CATH.FunFam:3.40.50.920:FF:000002
      label: 1-deoxy-D-xylulose-5-phosphate synthase
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.970:FF:000005
      curie: CATH.FunFam:3.40.50.970:FF:000005
      label: 1-deoxy-D-xylulose-5-phosphate synthase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 398. 398 carry GO:0006720 or a descendant with evidence
      other than ARBA (21 non-IEA, 377 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 13046.'
  - number: 50
    conditions:
    - condition_type: FUNFAM
      value: 3.90.1720.10:FF:000006
      curie: CATH.FunFam:3.90.1720.10:FF:000006
      label: Lecithin retinol acyltransferase
      negated: false
    - condition_type: TAXON
      value: Euarchontoglires
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 71.'
  - number: 51
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000036
      curie: CATH.FunFam:1.10.600.10:FF:000036
      label: cis-abienol synthase, chloroplastic
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 608.'
  - number: 52
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000171
      curie: CATH.FunFam:3.50.50.60:FF:000171
      label: zeta-carotene-forming phytoene desaturase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 784.'
  - number: 53
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000378
      curie: CATH.FunFam:3.50.50.60:FF:000378
      label: Phytoene desaturase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 7. 7 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 4 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1394.'
  - number: 54
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000413
      curie: CATH.FunFam:3.50.50.60:FF:000413
      label: Phytoene desaturase (lycopene-forming)
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 2 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 469.'
  - number: 55
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000042
      curie: CATH.FunFam:1.10.600.10:FF:000042
      label: Probable terpene synthase 3, chloroplastic
      negated: false
    - condition_type: FUNFAM
      value: 1.50.10.130:FF:000005
      curie: CATH.FunFam:1.50.10.130:FF:000005
      label: S-(+)-linalool synthase, chloroplastic
      negated: false
    - condition_type: TAXON
      value: Poales
      curie: NCBITaxon:38820
      label: Poales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 16.'
  - number: 56
    conditions:
    - condition_type: FUNFAM
      value: 1.50.10.20:FF:000002
      curie: CATH.FunFam:1.50.10.20:FF:000002
      label: Terpene cyclase/mutase family member
      negated: false
    - condition_type: FUNFAM
      value: 1.50.10.20:FF:000022
      curie: CATH.FunFam:1.50.10.20:FF:000022
      label: Terpene cyclase/mutase family member
      negated: false
    - condition_type: TAXON
      value: Fagales
      curie: NCBITaxon:3502
      label: Fagales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 22.'
  - number: 57
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000009
      curie: CATH.FunFam:2.10.25.10:FF:000009
      label: Low-density lipoprotein receptor isoform 1
      negated: false
    - condition_type: FUNFAM
      value: 4.10.400.10:FF:000011
      curie: CATH.FunFam:4.10.400.10:FF:000011
      label: Low-density lipoprotein receptor-related protein 1
      negated: false
    - condition_type: TAXON
      value: Catarrhini
      curie: NCBITaxon:9526
      label: Catarrhini
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 98. Matches are LRP1 (Q07954, GO:0001523 by TAS, Reactome:R-HSA-975634) and LRP2 (P98164).'
  - number: 58
    conditions:
    - condition_type: FUNFAM
      value: 3.30.300.30:FF:000007
      curie: CATH.FunFam:3.30.300.30:FF:000007
      label: 4-coumarate--CoA ligase 2
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.12780:FF:000003
      curie: CATH.FunFam:3.40.50.12780:FF:000003
      label: Long-chain-fatty-acid--CoA ligase FadD
      negated: false
    - condition_type: TAXON
      value: Pinopsida
      curie: NCBITaxon:58019
      label: Pinopsida
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 1 carry it only from ARBA; 0 do not carry it. Not supported: P41636
      (4CL 4-coumarate--CoA ligase). UniProtKB entries matching: 31.'
  - number: 59
    conditions:
    - condition_type: FUNFAM
      value: 3.40.1090.10:FF:000003
      curie: CATH.FunFam:3.40.1090.10:FF:000003
      label: Patatin-like phospholipase domain-containing protein 2
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1090.10:FF:000021
      curie: CATH.FunFam:3.40.1090.10:FF:000021
      label: Patatin-like phospholipase domain containing 2
      negated: false
    - condition_type: TAXON
      value: Eutheria
      curie: NCBITaxon:9347
      label: Eutheria
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 158. Matches are PNPLA2 (human Q96AD5, GO:0050253 by EXP, PMID:17603008).'
  - number: 60
    conditions:
    - condition_type: FUNFAM
      value: 1.10.274.20:FF:000003
      curie: CATH.FunFam:1.10.274.20:FF:000003
      label: Phenylalanine aminomutase (L-beta-phenylalanine forming)
      negated: false
    - condition_type: TAXON
      value: Pinidae
      curie: NCBITaxon:3313
      label: Pinidae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 5.'
  - number: 61
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000008
      curie: CATH.FunFam:1.10.600.10:FF:000008
      label: Farnesyl pyrophosphate synthase
      negated: false
    - condition_type: TAXON
      value: rosids
      curie: NCBITaxon:71275
      label: rosids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 6. 6 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 4 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 389.'
  - number: 62
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000021
      curie: CATH.FunFam:1.10.600.10:FF:000021
      label: Farnesyl pyrophosphate synthase
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 343.'
  - number: 63
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000052
      curie: CATH.FunFam:1.10.600.10:FF:000052
      label: Farnesyl pyrophosphate synthase
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 60.'
  - number: 64
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000076
      curie: CATH.FunFam:1.10.600.10:FF:000076
      label: Terpene synthase
      negated: false
    - condition_type: TAXON
      value: Amoebozoa
      curie: NCBITaxon:554915
      label: Amoebozoa
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2.'
  - number: 65
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000078
      curie: CATH.FunFam:1.10.600.10:FF:000078
      label: Terpene synthase
      negated: false
    - condition_type: TAXON
      value: Evosea
      curie: NCBITaxon:2605435
      label: Evosea
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 2.'
  - number: 66
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000009
      curie: CATH.FunFam:1.10.630.10:FF:000009
      label: Cytochrome P450 26B1 isoform 1
      negated: false
    - condition_type: TAXON
      value: Hominidae
      curie: NCBITaxon:9604
      label: Hominidae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 13.'
  - number: 67
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000011
      curie: CATH.FunFam:1.10.630.10:FF:000011
      label: Cytochrome P450 83B1
      negated: false
    - condition_type: TAXON
      value: Asterales
      curie: NCBITaxon:4209
      label: Asterales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 482.'
  - number: 68
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000014
      curie: CATH.FunFam:1.10.630.10:FF:000014
      label: Abscisic acid 8
      negated: false
    - condition_type: TAXON
      value: lamiids
      curie: NCBITaxon:91888
      label: lamiids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 270.'
  - number: 69
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000022
      curie: CATH.FunFam:1.10.630.10:FF:000022
      label: Taxadiene 5-alpha hydroxylase
      negated: false
    - condition_type: TAXON
      value: Caryophyllales
      curie: NCBITaxon:3524
      label: Caryophyllales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 41.'
  - number: 70
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000052
      curie: CATH.FunFam:1.10.630.10:FF:000052
      label: Ent-kaurenoic acid oxidase
      negated: false
    - condition_type: TAXON
      value: eudicotyledons
      curie: NCBITaxon:71240
      label: eudicotyledons
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 586.'
  - number: 71
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000062
      curie: CATH.FunFam:1.10.630.10:FF:000062
      label: Ent-kaurene oxidase 2
      negated: false
    - condition_type: TAXON
      value: Poaceae
      curie: NCBITaxon:4479
      label: Poaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 142.'
  - number: 72
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000080
      curie: CATH.FunFam:1.10.630.10:FF:000080
      label: Carotene epsilon-monooxygenase, chloroplastic
      negated: false
    - condition_type: TAXON
      value: Gunneridae
      curie: NCBITaxon:91827
      label: Gunneridae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 1 carry it only from ARBA; 0 do not carry it. Not supported: O23365
      (CYP97B3 Cytochrome P450 97B3, chloroplastic). UniProtKB entries matching: 256.'
  - number: 73
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000097
      curie: CATH.FunFam:1.10.630.10:FF:000097
      label: Cytochrome P-450 19
      negated: false
    - condition_type: TAXON
      value: PACMAD clade
      curie: NCBITaxon:147370
      label: PACMAD clade
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 82.'
  - number: 74
    conditions:
    - condition_type: FUNFAM
      value: 1.10.630.10:FF:000182
      curie: CATH.FunFam:1.10.630.10:FF:000182
      label: Cytochrome P450 3A4
      negated: false
    - condition_type: TAXON
      value: Homo
      curie: NCBITaxon:9605
      label: Homo
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 37.'
  - number: 75
    conditions:
    - condition_type: FUNFAM
      value: 2.40.400.10:FF:000003
      curie: CATH.FunFam:2.40.400.10:FF:000003
      label: Protein NEOXANTHIN-DEFICIENT 1
      negated: false
    - condition_type: TAXON
      value: Pentapetalae
      curie: NCBITaxon:1437201
      label: Pentapetalae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 41.'
  - number: 76
    conditions:
    - condition_type: FUNFAM
      value: 2.60.200.20:FF:000048
      curie: CATH.FunFam:2.60.200.20:FF:000048
      label: Zeaxanthin epoxidase, chloroplastic
      negated: false
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000263
      curie: CATH.FunFam:3.50.50.60:FF:000263
      label: Zeaxanthin epoxidase, chloroplastic
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 18.'
  - number: 77
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.150:FF:000539
      curie: CATH.FunFam:3.40.50.150:FF:000539
      label: juvenile hormone acid O-methyltransferase
      negated: false
    - condition_type: TAXON
      value: Arthropoda
      curie: NCBITaxon:6656
      label: Arthropoda
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 44.'
  - number: 78
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000019
      curie: CATH.FunFam:3.40.50.2000:FF:000019
      label: Glycosyltransferase
      negated: false
    - condition_type: TAXON
      value: Apiales
      curie: NCBITaxon:4036
      label: Apiales
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 61.'
  - number: 79
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000037
      curie: CATH.FunFam:3.40.50.2000:FF:000037
      label: Glycosyltransferase
      negated: false
    - condition_type: TAXON
      value: Caryophyllaceae
      curie: NCBITaxon:3568
      label: Caryophyllaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 25.'
  - number: 80
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.2000:FF:000047
      curie: CATH.FunFam:3.40.50.2000:FF:000047
      label: Glycosyltransferase
      negated: false
    - condition_type: TAXON
      value: Caryophylleae
      curie: NCBITaxon:1141493
      label: Caryophylleae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 20.'
  - number: 81
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000074
      curie: CATH.FunFam:3.50.50.60:FF:000074
      label: Squalene monooxygenase 2
      negated: false
    - condition_type: TAXON
      value: Araliaceae
      curie: NCBITaxon:4050
      label: Araliaceae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 22.'
  - number: 82
    conditions:
    - condition_type: FUNFAM
      value: 3.50.50.60:FF:000101
      curie: CATH.FunFam:3.50.50.60:FF:000101
      label: lycopene epsilon cyclase, chloroplastic
      negated: false
    - condition_type: TAXON
      value: Solaneae
      curie: NCBITaxon:424574
      label: Solaneae
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (4 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 47.'
  - number: 83
    conditions:
    - condition_type: FUNFAM
      value: 3.90.79.10:FF:000025
      curie: CATH.FunFam:3.90.79.10:FF:000025
      label: isopentenyl-diphosphate Delta-isomerase I
      negated: false
    - condition_type: TAXON
      value: malvids
      curie: NCBITaxon:91836
      label: malvids
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 5. 5 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 3 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 163.'
  - number: 84
    conditions:
    - condition_type: FUNFAM
      value: 1.10.600.10:FF:000011
      curie: CATH.FunFam:1.10.600.10:FF:000011
      label: Decaprenyl diphosphate synthase subunit 1
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 1242.'
  - number: 85
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.330:FF:000021
      curie: CATH.FunFam:2.60.120.330:FF:000021
      label: Gibberellin 2-beta-dioxygenase 8
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 804.'
  - number: 86
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.330:FF:000025
      curie: CATH.FunFam:2.60.120.330:FF:000025
      label: Gibberellin 2-beta-dioxygenase 2
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 4. 4 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 1 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 845.'
  - number: 87
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.330:FF:000050
      curie: CATH.FunFam:2.60.120.330:FF:000050
      label: Gibberellin 2-beta-dioxygenase 7
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 2. 2 carry GO:0006720 or a descendant with evidence
      other than ARBA (2 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 24.'
  - number: 88
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.11270:FF:000001
      curie: CATH.FunFam:3.40.50.11270:FF:000001
      label: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 72. 72 carry GO:0006720 or a descendant with evidence
      other than ARBA (5 non-IEA, 67 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 641.'
  - number: 89
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.720:FF:000131
      curie: CATH.FunFam:3.40.50.720:FF:000131
      label: Short-chain dehydrogenase/reductase 3
      negated: false
    notes: 'Swiss-Prot entries matching this set (2026-11-09): 3. 3 carry GO:0006720 or a descendant with evidence
      other than ARBA (3 non-IEA, 0 other IEA); 0 carry it only from ARBA; 0 do not carry it. UniProtKB entries
      matching: 5347.'
  go_annotations:
  - go_id: GO:0006720
    go_label: isoprenoid metabolic process
    aspect: BP
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 89
review_summary: 'All 89 live condition sets were queried. Each set was turned into a UniProtKB query and its Swiss-Prot
  matches were inspected on 2026-11-09. A match counts as supported when it carries the term or an is_a/part_of
  descendant with evidence other than ARBA; annotations placed by ARBA rules on Swiss-Prot entries were not counted.
  Every set has reviewed matches. In 75 sets every reviewed match is supported and in 14 sets (CS1, CS5, CS7, CS9,
  CS18, CS22, CS25, CS30, CS35, CS37, CS42, CS47, CS58, CS72) some are not. One of these is a demonstrable defect:
  CS18 (PANTHER PTHR43734 in Pseudomonadati) matches GlpB, a glycerol-3-phosphate dehydrogenase subunit with no
  isoprenoid role, in 8 of its 22 reviewed matches. Two further matches are doubtful: Q6PQJ9, a 3-oxo-Delta(4,5)-steroid
  5-beta-reductase that carries the term only from this rule (CS37), and Q54E48, an NADH dehydrogenase assembly
  factor homologue (CS1). The retinoid-related sets on ADH7, hormone-sensitive lipase, PNPLA2, LRP1 and CYP2C family
  members are supported by curated annotation in the isoprenoid branch. QuickGO lists 9043 annotations attributed
  to this rule, while the rule statistics served by UniProt report zero proteins.'
action: MODIFY
action_rationale: The term is supported for 75 sets outright and for most matches of the rest, so the rule should
  be kept. CS18 as published matches GlpB proteins, which are not isoprenoid enzymes, and needs a further condition.
suggested_modifications:
- 'CS18 (PANTHER PTHR43734 AND Pseudomonadati): exclude GlpB, for example by adding NOT InterPro IPR009158 (Glycerol-3-phosphate
  dehydrogenase, GlpB subunit), or by requiring a carotenoid desaturase subfamily of PTHR43734.'
- 'CS37 (FunFam 3.40.50.720:FF:000808 AND asterids): check whether the 3-oxo-Delta(4,5)-steroid 5-beta-reductases
  it matches (Q6PQJ9) belong under the term; steroid metabolic process GO:0008202 is not a descendant of GO:0006720.'
go_specificity:
  assessment: APPROPRIATE
  notes: 'The sets span terpenoid, carotenoid, retinoid and prenyl diphosphate metabolism, for which GO:0006720
    is the common ancestor: retinoid metabolic process GO:0001523 and monoterpenoid metabolic process GO:0016098
    are both among its descendants (QuickGO, is_a/part_of).'
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0006720
  label: isoprenoid metabolic process
  assessment: PARTIALLY_CORRECT
  correct_examples:
  - Q9HAY6
  - Q16518
  - O95749
  - P40394
  - P28474
  - P11712
  - Q05469
  - Q96AD5
  incorrect_examples:
  - Q8ZAH6
  - A1JIB0
  - Q1CNF8
  - Q6CZI7
  - Q1CBK6
  - A4WCP1
  - C6DH98
  - Q66FX5
  discriminating_features:
  - InterPro:IPR009158
  notes: 'Supported: Q9HAY6 (BCO1), Q16518 (RPE65) and O95749 (GGPS1) match CS4 or CS10 and carry descendants of
    the term with non-ARBA evidence. P40394 (ADH7): GO:0001523 IDA PMID:16787387. P28474 (mouse Adh5): GO:0001523
    IMP PMID:12027900 (MGI). P11712 (CYP2C9): GO:0016098 IDA PMID:16401082. Q05469 (LIPE): GO:0050253 IDA PMID:15955102.
    Q96AD5 (PNPLA2): GO:0050253 EXP PMID:17603008. Not supported: the eight GlpB entries listed match the conditions
    of CS18; Q8ZAH6 is named Anaerobic glycerol-3-phosphate dehydrogenase subunit B, EC 1.1.5.3, by HAMAP MF_00753
    and has PANTHER PTHR43734. QuickGO shows no GO:0006720 annotation from this rule on Q8ZAH6, so the defect is
    in the published conditions and was not seen in emitted annotations. Q6PQJ9 does carry GO:0006720 IEA GO_REF:0000117
    with ARBA:ARBA00027853.'
confidence: 0.6
references:
- id: PMID:37623827
  title: Biosynthetic Pathways of Hormones in Plants.
- id: PMID:36830762
  title: Promiscuity, a Driver of Plant Cytochrome P450 Evolution?
- id: PMID:31632418
  title: Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid
corrections:
- date: '2026-11-10'
  withdrawn_claim: ADH5 (class III alcohol dehydrogenase) does not act on retinol and has no isoprenoid role; its
    condition set, restricted to Mus, is the clearest single error in the rule.
  correction: Mouse Adh5 carries an experimental retinoid metabolic process annotation, which is in the isoprenoid
    branch and explains the Mus restriction. The live rule no longer has this set.
  error_type: REFUTED_BY_CURATED_ANNOTATION
  evidence:
  - 'UniProtKB P28474 (Adh5, Mus musculus): GO:0001523 retinoid metabolic process, IMP, PMID:12027900, assigned
    by MGI'
  - 'QuickGO: GO:0001523 is a descendant of GO:0006720'
  - 'Live rule (2026-11-09): no condition with FunFam 3.90.180.10:FF:000001'
- date: '2026-11-10'
  withdrawn_claim: The condition sets on ADH7, CYP2C9, hormone-sensitive lipase and PNPLA2 are off-target and indefensible,
    and should be removed.
  correction: Each of these proteins carries a curated, non-electronic annotation in the isoprenoid branch, and
    every reviewed match of the corresponding live sets is supported. Whether a minor activity deserves the term
    is a judgement, but the sets are not unsupported.
  error_type: REFUTED_BY_CURATED_ANNOTATION
  evidence:
  - 'P40394 (ADH7): GO:0001523 IDA PMID:16787387 and PMID:9600267'
  - 'P11712 (CYP2C9): GO:0016098 monoterpenoid metabolic process IDA PMID:16401082 (BHF-UCL)'
  - 'Q05469 (LIPE): GO:0050253 retinyl-palmitate esterase activity IDA PMID:15955102'
  - 'Q96AD5 (PNPLA2): GO:0050253 EXP PMID:17603008'
  - Live CS41 7 of 7, CS40 6 of 6, CS59 4 of 4 and CS35 4 of 5 Swiss-Prot matches supported
- date: '2026-11-10'
  withdrawn_claim: The LDLR/LRP1 set fails even on its intended inference, because the cargo is cholesterol and
    steroid metabolic process is not under isoprenoid metabolic process.
  correction: The curated annotation behind the set is retinoid metabolic process on LRP1, not a steroid term. The
    objection that a receptor is not a metabolic enzyme stands on its own and is not settled here.
  error_type: ONTOLOGY_MISREAD
  evidence:
  - 'UniProtKB Q07954 (LRP1): GO:0001523 retinoid metabolic process, TAS, Reactome:R-HSA-975634'
  - 'Live CS57: 2 Swiss-Prot matches (Q07954, P98164), both supported'
- date: '2026-11-10'
  withdrawn_claim: 'The annotations the rule emits cannot be reproduced from its condition sets: most carotenoid
    oxygenase proteins annotated are not mammals although the only IPR004294 set requires Mammalia, and most IPR000092
    proteins lack the co-required IPR039702. This is the most serious defect, and no per-set decision can be verified
    until UniProt explains it.'
  correction: The comparison used an older copy of the rule. The rule UniProt serves now requires Metazoa with IPR004294
    and has a separate IPR000092 set that does not need IPR039702, which fits the annotations described.
  error_type: STALE_RULE_VERSION
  evidence:
  - 'Earlier copy: modified_date 2025-12-15, 94 condition sets'
  - 'rest.uniprot.org/arba/ARBA00027853 on 2026-11-09: modifiedDate 2026-07-18, 89 condition sets; CS4 = IPR004294
    AND Metazoa; CS10 = IPR000092 AND PANTHER PTHR12001 AND Chordata'
  - 'Swiss-Prot matches of live CS4: 23, all supported (BCO1, BCO2, RPE65); of live CS10: 9, all supported (GGPS1,
    PDSS1, PDSS2)'
- date: '2026-11-10'
  withdrawn_claim: A set requiring two different FunFams of the same CATH superfamily cannot be satisfied by one
    protein and is a dead branch.
  correction: Sets of that shape in the live rule have Swiss-Prot matches.
  error_type: UNEXAMINED_RULE
  evidence:
  - 'Live CS40 (FunFams 3.40.50.1820:FF:000110 AND 3.40.50.1820:FF:000199, Craniata): 6 Swiss-Prot matches'
  - 'Live CS59 (FunFams 3.40.1090.10:FF:000003 AND 3.40.1090.10:FF:000021, Eutheria): 4 Swiss-Prot matches'
- date: '2026-11-10'
  withdrawn_claim: Three FunFam sets need fixing because the FunFam label names an enzyme that cannot occur in the
    clade the set is restricted to.
  correction: A FunFam label is the name of one representative member, not a statement about every member, so a
    label from another clade does not show the set is wrong.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'UniProtKB Q9BSE5 carries FunFam 3.40.800.10:FF:000002 labelled Agmatinase while curated as an arginase: an
    example of a FunFam label that does not describe the member'
- date: '2026-11-10'
  withdrawn_claim: The taxonomic scope is too narrow because sets on conserved enzymes (ADH5 in Mus, CYP2C9 in Primates,
    LDLR/LRP1 in Catarrhini) are pinned to small clades.
  correction: A narrow taxon limits coverage and cannot make an annotation wrong. Several of the sets cited were
    ones the same review wanted removed.
  error_type: LOW_RECALL_IS_NOT_WRONG
  evidence:
  - 'Live rule: 70 of 89 sets carry a taxon condition; all 89 have supported Swiss-Prot matches'