ARBA00028131 endopeptidase activity (GO:0004175)

View original ARBA rule on UniProt

Type: ARBA
Status: COMPLETE
Action: MODIFY
Confidence: 0.55

Description

Assigns GO:0004175 (endopeptidase activity) through 104 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover caspases, papain-like and legumain cysteine peptidases, aspartic peptidases, proteasome subunits, signal peptidases, trypsin- and subtilisin-like serine peptidases and several metallopeptidase families.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
104
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00028131 and re-render to add it.

Review Summary

All 104 live condition sets were checked against Swiss-Prot. They match 1063 reviewed entries in total and every one carries GO:0004175 or a descendant, 630 by manual evidence. One set is weakly founded: set 14 is the single InterPro entry IPR003675, which matches 56399 unreviewed entries. Of its 40 reviewed matches only 10, all CAAX prenyl protease 2 orthologues, have a manual annotation; the other 30, which include lysostaphin resistance protein A and proteins named as uncharacterised, carry the term only from this rule.

Action Rationale

Set 14 extends an activity shown for CAAX prenyl protease 2 to a whole domain family whose other reviewed members have no independent support for it. The set should be narrowed to the characterised subfamily. No defect was found in the other 103 sets, which were checked by counts only. The counts are from Swiss-Prot, which is also what ARBA learns its rules from, so they show the condition sets are coherent rather than giving an independent error rate for unreviewed entries.

GO Annotations

GO:0004175 - endopeptidase activity
Aspect: MF

Annotation Assessments

UNDECIDED GO_TERM GO:0004175 - endopeptidase activity
Matched proteins: 1063; incorrect:
Correct examples: Q9Y256, Q8GW19, Q6LZY8, G5EDW2, Q9UTT1

UniProtKB release 2026_04: set 14 matches 40 reviewed and 56399 unreviewed entries. Manual annotations to GO:0004175 in set 14 (QuickGO, retrieved 2026-11-09): Q9Y256 (human RCE1), IDA, PMID:19188362; Q8GW19 (Arabidopsis FACE2), IDA, PMID:12928436; Q6LZY8 (Methanococcus maripaludis rce1), IDA, PMID:24291792. Reviewed matches of set 14 whose only annotation to the term is IEA, GO_REF:0000117: Q2FVT1 (Staphylococcus aureus lyrA), P50730 (Bacillus subtilis ypbD, Uncharacterized protein YpbD), Q9CDG9 (Lactococcus lactis yxdF, UPF0177 protein YxdF). These are unsupported, not shown to be wrong. Other sets with unusual families are supported: set 82, G5EDW2 (Caenorhabditis elegans lat-1), IDA, PMID:22938866; set 94, Q9UTT1 (Schizosaccharomyces pombe ubp15), IDA, PMID:28947618.

Rule Definition

Condition Sets

Condition Set 1

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or a descendant, 14 of those by a manual-evidence GO annotation. 791 unreviewed entries match.

Condition Set 2

3 condition(s)
Notes:

UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or a descendant, 9 of those by a manual-evidence GO annotation. 333 unreviewed entries match.

Condition Set 3

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or a descendant, 9 of those by a manual-evidence GO annotation. 96 unreviewed entries match.

Condition Set 4

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or a descendant, 13 of those by a manual-evidence GO annotation. 341 unreviewed entries match.

Condition Set 5

3 condition(s)
Notes:

UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 4470 unreviewed entries match.

Condition Set 6

3 condition(s)
Notes:

UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0004175 or a descendant, 16 of those by a manual-evidence GO annotation. 652 unreviewed entries match.

Condition Set 7

3 condition(s)
Notes:

UniProtKB release 2026_04: 166 reviewed entries match this set; 166 of them carry GO:0004175 or a descendant, 19 of those by a manual-evidence GO annotation. 1704 unreviewed entries match.

Condition Set 8

3 condition(s)
Notes:

UniProtKB release 2026_04: 18 reviewed entries match this set; 18 of them carry GO:0004175 or a descendant, 11 of those by a manual-evidence GO annotation. 216 unreviewed entries match.

Condition Set 9

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or a descendant, 10 of those by a manual-evidence GO annotation. 5023 unreviewed entries match.

Condition Set 10

2 condition(s)
Notes:

UniProtKB release 2026_04: 86 reviewed entries match this set; 86 of them carry GO:0004175 or a descendant, 84 of those by a manual-evidence GO annotation. 9282 unreviewed entries match.

Condition Set 11

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or a descendant, 14 of those by a manual-evidence GO annotation. 157 unreviewed entries match.

Condition Set 12

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 26 unreviewed entries match.

Condition Set 13

3 condition(s)
Notes:

UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0004175 or a descendant, 12 of those by a manual-evidence GO annotation. 972 unreviewed entries match.

Condition Set 14

1 condition(s)
Notes:

UniProtKB release 2026_04: 40 reviewed entries match this set; 40 of them carry GO:0004175 or a descendant, 10 of those by a manual-evidence GO annotation. 56399 unreviewed entries match. Only the 10 CAAX prenyl protease 2 orthologues among the reviewed matches have a manual annotation; the other 30 carry the term only as IEA from this rule. This set should be narrowed.

Condition Set 15

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 1618 unreviewed entries match.

Condition Set 16

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 79 unreviewed entries match.

Condition Set 17

3 condition(s)
Notes:

UniProtKB release 2026_04: 18 reviewed entries match this set; 18 of them carry GO:0004175 or a descendant, 12 of those by a manual-evidence GO annotation. 7207 unreviewed entries match.

Condition Set 18

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 64 unreviewed entries match.

Condition Set 19

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 3190 unreviewed entries match.

Condition Set 20

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 3234 unreviewed entries match.

Condition Set 21

3 condition(s)
Notes:

UniProtKB release 2026_04: 30 reviewed entries match this set; 30 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 28823 unreviewed entries match.

Condition Set 22

2 condition(s)
Notes:

UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or a descendant, 11 of those by a manual-evidence GO annotation. 2559 unreviewed entries match.

Condition Set 23

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 30 unreviewed entries match.

Condition Set 24

2 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 309 unreviewed entries match.

Condition Set 25

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or a descendant, 11 of those by a manual-evidence GO annotation. 49 unreviewed entries match.

Condition Set 26

2 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 78 unreviewed entries match.

Condition Set 27

2 condition(s)
Notes:

UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0004175 or a descendant, 12 of those by a manual-evidence GO annotation. 857 unreviewed entries match.

Condition Set 28

2 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 105 unreviewed entries match.

Condition Set 29

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 2167 unreviewed entries match.

Condition Set 30

1 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 1308 unreviewed entries match.

Condition Set 31

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 307 unreviewed entries match.

Condition Set 32

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 284 unreviewed entries match.

Condition Set 33

3 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or a descendant, 10 of those by a manual-evidence GO annotation. 338 unreviewed entries match.

Condition Set 34

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 1004 unreviewed entries match.

Condition Set 35

3 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 178 unreviewed entries match.

Condition Set 36

3 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 234 unreviewed entries match.

Condition Set 37

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 27 unreviewed entries match.

Condition Set 38

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 1667 unreviewed entries match.

Condition Set 39

2 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 83 unreviewed entries match.

Condition Set 40

2 condition(s)
Notes:

UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or a descendant, 11 of those by a manual-evidence GO annotation. 563 unreviewed entries match.

Condition Set 41

2 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 2873 unreviewed entries match.

Condition Set 42

2 condition(s)
Notes:

UniProtKB release 2026_04: 48 reviewed entries match this set; 48 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 766 unreviewed entries match.

Condition Set 43

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 96 unreviewed entries match.

Condition Set 44

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 142 unreviewed entries match.

Condition Set 45

3 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 108 unreviewed entries match.

Condition Set 46

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 732 unreviewed entries match.

Condition Set 47

3 condition(s)
Notes:

UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 140 unreviewed entries match.

Condition Set 48

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 51 unreviewed entries match.

Condition Set 49

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 134 unreviewed entries match.

Condition Set 50

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 380 unreviewed entries match.

Condition Set 51

3 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 1195 unreviewed entries match.

Condition Set 52

2 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 361 unreviewed entries match.

Condition Set 53

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 5 unreviewed entries match.

Condition Set 54

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 36 unreviewed entries match.

Condition Set 55

2 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 289 unreviewed entries match.

Condition Set 56

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 930 unreviewed entries match.

Condition Set 57

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 31 unreviewed entries match.

Condition Set 58

2 condition(s)
Notes:

UniProtKB release 2026_04: 29 reviewed entries match this set; 29 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 1099 unreviewed entries match.

Condition Set 59

2 condition(s)
Notes:

UniProtKB release 2026_04: 31 reviewed entries match this set; 31 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 1199 unreviewed entries match.

Condition Set 60

2 condition(s)
Notes:

UniProtKB release 2026_04: 53 reviewed entries match this set; 53 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 314 unreviewed entries match.

Condition Set 61

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 699 unreviewed entries match.

Condition Set 62

1 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 266 unreviewed entries match.

Condition Set 63

1 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 1167 unreviewed entries match.

Condition Set 64

1 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or a descendant, 4 of those by a manual-evidence GO annotation. 247 unreviewed entries match.

Condition Set 65

1 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 1890 unreviewed entries match.

Condition Set 66

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 452 unreviewed entries match.

Condition Set 67

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 318 unreviewed entries match.

Condition Set 68

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 72 unreviewed entries match.

Condition Set 69

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 39 unreviewed entries match.

Condition Set 70

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 963 unreviewed entries match.

Condition Set 71

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 19 unreviewed entries match.

Condition Set 72

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 17 unreviewed entries match.

Condition Set 73

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 1290 unreviewed entries match.

Condition Set 74

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 21 unreviewed entries match.

Condition Set 75

3 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 1394 unreviewed entries match.

Condition Set 76

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 4 unreviewed entries match.

Condition Set 77

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 949 unreviewed entries match.

Condition Set 78

3 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 234 unreviewed entries match.

Condition Set 79

3 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 0 unreviewed entries match.

Condition Set 80

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 267 unreviewed entries match.

Condition Set 81

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 303 unreviewed entries match.

Condition Set 82

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 97 unreviewed entries match.

Condition Set 83

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.

Condition Set 84

2 condition(s)
Notes:

UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or a descendant, 6 of those by a manual-evidence GO annotation. 178 unreviewed entries match.

Condition Set 85

2 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0004175 or a descendant, 8 of those by a manual-evidence GO annotation. 736 unreviewed entries match.

Condition Set 86

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 10 unreviewed entries match.

Condition Set 87

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 322 unreviewed entries match.

Condition Set 88

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 365 unreviewed entries match.

Condition Set 89

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 478 unreviewed entries match.

Condition Set 90

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 703 unreviewed entries match.

Condition Set 91

2 condition(s)
Notes:

UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.

Condition Set 92

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 20 unreviewed entries match.

Condition Set 93

2 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.

Condition Set 94

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.

Condition Set 95

2 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 122 unreviewed entries match.

Condition Set 96

1 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 690 unreviewed entries match.

Condition Set 97

1 condition(s)
Notes:

UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or a descendant, 7 of those by a manual-evidence GO annotation. 1406 unreviewed entries match.

Condition Set 98

1 condition(s)
Notes:

UniProtKB release 2026_04: 16 reviewed entries match this set; 16 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 3505 unreviewed entries match.

Condition Set 99

1 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 360 unreviewed entries match.

Condition Set 100

1 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 122 unreviewed entries match.

Condition Set 101

1 condition(s)
Notes:

UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 1163 unreviewed entries match.

Condition Set 102

1 condition(s)
Notes:

UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or a descendant, 3 of those by a manual-evidence GO annotation. 616 unreviewed entries match.

Condition Set 103

1 condition(s)
Notes:

UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or a descendant, 5 of those by a manual-evidence GO annotation. 3423 unreviewed entries match.

Condition Set 104

1 condition(s)
Notes:

UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or a descendant, 2 of those by a manual-evidence GO annotation. 42 unreviewed entries match.

Assessments

Raw YAML

View Source YAML 
id: ARBA00028131
description: >-
  Assigns GO:0004175 (endopeptidase activity) through 104 alternative condition sets built from InterPro
  entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover caspases, papain-like
  and legumain cysteine peptidases, aspartic peptidases, proteasome subunits, signal peptidases, trypsin-
  and subtilisin-like serine peptidases and several metallopeptidase families.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00028131
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR001309
      curie: InterPro:IPR001309
      label: Peptidase C14, p20 domain
      negated: false
    - condition_type: INTERPRO
      value: IPR016129
      curie: InterPro:IPR016129
      label: Peptidase family C14A, His active site
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or
      a descendant, 14 of those by a manual-evidence GO annotation. 791 unreviewed entries match.
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR000169
      curie: InterPro:IPR000169
      label: Cysteine peptidase, cysteine active site
      negated: false
    - condition_type: INTERPRO
      value: IPR039417
      curie: InterPro:IPR039417
      label: Papain-like cysteine endopeptidase
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or
      a descendant, 9 of those by a manual-evidence GO annotation. 333 unreviewed entries match.
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR000395
      curie: InterPro:IPR000395
      label: Botulinum/Tetanus toxin, catalytic chain
      negated: false
    - condition_type: INTERPRO
      value: IPR011065
      curie: InterPro:IPR011065
      label: Kunitz inhibitor STI-like superfamily
      negated: false
    - condition_type: TAXON
      value: Clostridium botulinum group
      curie: NCBITaxon:3691983
      label: Clostridium botulinum group
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or
      a descendant, 9 of those by a manual-evidence GO annotation. 96 unreviewed entries match.
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR001254
      curie: InterPro:IPR001254
      label: Serine proteases, trypsin domain
      negated: false
    - condition_type: INTERPRO
      value: IPR018097
      curie: InterPro:IPR018097
      label: EGF-like calcium-binding, conserved site
      negated: false
    - condition_type: TAXON
      value: Catarrhini
      curie: NCBITaxon:9526
      label: Catarrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or
      a descendant, 13 of those by a manual-evidence GO annotation. 341 unreviewed entries match.
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR001969
      curie: InterPro:IPR001969
      label: Aspartic peptidase, active site
      negated: false
    - condition_type: INTERPRO
      value: IPR034164
      curie: InterPro:IPR034164
      label: Pepsin-like domain
      negated: false
    - condition_type: PANTHER
      value: PTHR47966:SF51
      curie: PANTHER:PTHR47966:SF51
      label: BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED
      negated: false
    notes: >-
      UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 4470 unreviewed entries match.
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR000152
      curie: InterPro:IPR000152
      label: EGF-type aspartate/asparagine hydroxylation site
      negated: false
    - condition_type: INTERPRO
      value: IPR000294
      curie: InterPro:IPR000294
      label: Gamma-carboxyglutamic acid-rich (GLA) domain
      negated: false
    - condition_type: PANTHER
      value: PTHR24278:SF28
      curie: PANTHER:PTHR24278:SF28
      label: COAGULATION FACTOR X
      negated: false
    notes: >-
      UniProtKB release 2026_04: 20 reviewed entries match this set; 20 of them carry GO:0004175 or
      a descendant, 16 of those by a manual-evidence GO annotation. 652 unreviewed entries match.
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR001353
      curie: InterPro:IPR001353
      label: Proteasome, subunit alpha/beta
      negated: false
    - condition_type: INTERPRO
      value: IPR029055
      curie: InterPro:IPR029055
      label: Nucleophile aminohydrolases, N-terminal
      negated: false
    - condition_type: TAXON
      value: Archaea
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: >-
      UniProtKB release 2026_04: 166 reviewed entries match this set; 166 of them carry GO:0004175
      or a descendant, 19 of those by a manual-evidence GO annotation. 1704 unreviewed entries match.
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR001461
      curie: InterPro:IPR001461
      label: Aspartic peptidase A1
      negated: false
    - condition_type: INTERPRO
      value: IPR012848
      curie: InterPro:IPR012848
      label: Aspartic peptidase, N-terminal
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: >-
      UniProtKB release 2026_04: 18 reviewed entries match this set; 18 of them carry GO:0004175 or
      a descendant, 11 of those by a manual-evidence GO annotation. 216 unreviewed entries match.
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR001915
      curie: InterPro:IPR001915
      label: Peptidase M48
      negated: false
    - condition_type: PANTHER
      value: PTHR10120
      curie: PANTHER:PTHR10120
      label: CAAX PRENYL PROTEASE 1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or
      a descendant, 10 of those by a manual-evidence GO annotation. 5023 unreviewed entries match.
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR001733
      curie: InterPro:IPR001733
      label: Peptidase S26B
      negated: false
    - condition_type: INTERPRO
      value: IPR036286
      curie: InterPro:IPR036286
      label: LexA/Signal peptidase-like superfamily
      negated: false
    notes: >-
      UniProtKB release 2026_04: 86 reviewed entries match this set; 86 of them carry GO:0004175 or
      a descendant, 84 of those by a manual-evidence GO annotation. 9282 unreviewed entries match.
  - number: 11
    conditions:
    - condition_type: INTERPRO
      value: IPR000436
      curie: InterPro:IPR000436
      label: Sushi/SCR/CCP domain
      negated: false
    - condition_type: INTERPRO
      value: IPR033116
      curie: InterPro:IPR033116
      label: Serine proteases, trypsin family, serine active site
      negated: false
    - condition_type: TAXON
      value: Hominidae
      curie: NCBITaxon:9604
      label: Hominidae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or
      a descendant, 14 of those by a manual-evidence GO annotation. 157 unreviewed entries match.
  - number: 12
    conditions:
    - condition_type: INTERPRO
      value: IPR002138
      curie: InterPro:IPR002138
      label: Peptidase C14, caspase non-catalytic subunit p10
      negated: false
    - condition_type: INTERPRO
      value: IPR011029
      curie: InterPro:IPR011029
      label: Death-like domain superfamily
      negated: false
    - condition_type: TAXON
      value: Mus
      curie: NCBITaxon:10088
      label: Mus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 26 unreviewed entries match.
  - number: 13
    conditions:
    - condition_type: INTERPRO
      value: IPR021109
      curie: InterPro:IPR021109
      label: Aspartic peptidase domain superfamily
      negated: false
    - condition_type: INTERPRO
      value: IPR033121
      curie: InterPro:IPR033121
      label: Peptidase family A1 domain
      negated: false
    - condition_type: PANTHER
      value: PTHR47966:SF24
      curie: PANTHER:PTHR47966:SF24
      label: RENIN
      negated: false
    notes: >-
      UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0004175 or
      a descendant, 12 of those by a manual-evidence GO annotation. 972 unreviewed entries match.
  - number: 14
    conditions:
    - condition_type: INTERPRO
      value: IPR003675
      curie: InterPro:IPR003675
      label: CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain
      negated: false
    notes: >-
      UniProtKB release 2026_04: 40 reviewed entries match this set; 40 of them carry GO:0004175 or
      a descendant, 10 of those by a manual-evidence GO annotation. 56399 unreviewed entries match.
      Only the 10 CAAX prenyl protease 2 orthologues among the reviewed matches have a manual annotation;
      the other 30 carry the term only as IEA from this rule. This set should be narrowed.
  - number: 15
    conditions:
    - condition_type: INTERPRO
      value: IPR000209
      curie: InterPro:IPR000209
      label: Peptidase S8/S53 domain
      negated: false
    - condition_type: INTERPRO
      value: IPR002884
      curie: InterPro:IPR002884
      label: P domain
      negated: false
    - condition_type: PANTHER
      value: PTHR42884:SF13
      curie: PANTHER:PTHR42884:SF13
      label: NEUROENDOCRINE CONVERTASE 2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 1618 unreviewed entries match.
  - number: 16
    conditions:
    - condition_type: INTERPRO
      value: IPR000859
      curie: InterPro:IPR000859
      label: CUB domain
      negated: false
    - condition_type: PANTHER
      value: PTHR24255
      curie: PANTHER:PTHR24255
      label: COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED
      negated: false
    - condition_type: TAXON
      value: Homo
      curie: NCBITaxon:9605
      label: Homo
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 79 unreviewed entries match.
  - number: 17
    conditions:
    - condition_type: INTERPRO
      value: IPR001431
      curie: InterPro:IPR001431
      label: Peptidase M16, zinc-binding site
      negated: false
    - condition_type: INTERPRO
      value: IPR007863
      curie: InterPro:IPR007863
      label: Peptidase M16, C-terminal
      negated: false
    - condition_type: INTERPRO
      value: IPR054734
      curie: InterPro:IPR054734
      label: Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4
      negated: false
    notes: >-
      UniProtKB release 2026_04: 18 reviewed entries match this set; 18 of them carry GO:0004175 or
      a descendant, 12 of those by a manual-evidence GO annotation. 7207 unreviewed entries match.
  - number: 18
    conditions:
    - condition_type: INTERPRO
      value: IPR001478
      curie: InterPro:IPR001478
      label: PDZ domain
      negated: false
    - condition_type: INTERPRO
      value: IPR036034
      curie: InterPro:IPR036034
      label: PDZ superfamily
      negated: false
    - condition_type: TAXON
      value: Escherichia
      curie: NCBITaxon:561
      label: Escherichia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 64 unreviewed entries match.
  - number: 19
    conditions:
    - condition_type: INTERPRO
      value: IPR001818
      curie: InterPro:IPR001818
      label: Peptidase M10, metallopeptidase
      negated: false
    - condition_type: INTERPRO
      value: IPR002477
      curie: InterPro:IPR002477
      label: Peptidoglycan binding-like
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 3190 unreviewed entries match.
  - number: 20
    conditions:
    - condition_type: INTERPRO
      value: IPR011600
      curie: InterPro:IPR011600
      label: Peptidase C14, caspase domain
      negated: false
    - condition_type: INTERPRO
      value: IPR015917
      curie: InterPro:IPR015917
      label: Peptidase C14A, caspase catalytic domain
      negated: false
    - condition_type: PANTHER
      value: PTHR48169:SF7
      curie: PANTHER:PTHR48169:SF7
      label: CASPASE 10
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 3234 unreviewed entries match.
  - number: 21
    conditions:
    - condition_type: INTERPRO
      value: IPR015500
      curie: InterPro:IPR015500
      label: Peptidase S8, subtilisin-related
      negated: false
    - condition_type: PANTHER
      value: PTHR43806:SF11
      curie: PANTHER:PTHR43806:SF11
      label: CEREVISIN-RELATED
      negated: false
    - condition_type: TAXON
      value: Bacillati
      curie: NCBITaxon:1783272
      label: Bacillati
      negated: false
    notes: >-
      UniProtKB release 2026_04: 30 reviewed entries match this set; 30 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 28823 unreviewed entries match.
  - number: 22
    conditions:
    - condition_type: INTERPRO
      value: IPR001096
      curie: InterPro:IPR001096
      label: Peptidase C13, legumain
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or
      a descendant, 11 of those by a manual-evidence GO annotation. 2559 unreviewed entries match.
  - number: 23
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000035
      curie: CATH.FunFam:2.40.70.10:FF:000035
      label: Plasmepsin-2
      negated: false
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000038
      curie: CATH.FunFam:2.40.70.10:FF:000038
      label: Plasmepsin-2
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 30 unreviewed entries match.
  - number: 24
    conditions:
    - condition_type: FUNFAM
      value: 3.40.390.10:FF:000007
      curie: CATH.FunFam:3.40.390.10:FF:000007
      label: Collagenase 3
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 309 unreviewed entries match.
  - number: 25
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000162
      curie: CATH.FunFam:2.10.25.10:FF:000162
      label: Coagulation factor X (Predicted)
      negated: false
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000513
      curie: CATH.FunFam:2.10.25.10:FF:000513
      label: Coagulation factor VII
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000011
      curie: CATH.FunFam:2.40.10.10:FF:000011
      label: Coagulation factor X
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or
      a descendant, 11 of those by a manual-evidence GO annotation. 49 unreviewed entries match.
  - number: 26
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1120.10:FF:000001
      curie: CATH.FunFam:1.20.1120.10:FF:000001
      label: Botulinum neurotoxin type A
      negated: false
    - condition_type: TAXON
      value: Clostridium botulinum group
      curie: NCBITaxon:3691983
      label: Clostridium botulinum group
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 78 unreviewed entries match.
  - number: 27
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000032
      curie: CATH.FunFam:2.40.70.10:FF:000032
      label: renin
      negated: false
    - condition_type: TAXON
      value: Metazoa
      curie: NCBITaxon:33208
      label: Metazoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 12 reviewed entries match this set; 12 of them carry GO:0004175 or
      a descendant, 12 of those by a manual-evidence GO annotation. 857 unreviewed entries match.
  - number: 28
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.380:FF:000012
      curie: CATH.FunFam:2.60.120.380:FF:000012
      label: Microbial collagenase
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 105 unreviewed entries match.
  - number: 29
    conditions:
    - condition_type: FUNFAM
      value: 3.40.390.10:FF:000018
      curie: CATH.FunFam:3.40.390.10:FF:000018
      label: Metalloendoproteinase 1
      negated: false
    - condition_type: TAXON
      value: Viridiplantae
      curie: NCBITaxon:33090
      label: Viridiplantae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 2167 unreviewed entries match.
  - number: 30
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000004
      curie: CATH.FunFam:3.40.50.200:FF:000004
      label: Proprotein convertase type 2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 1308 unreviewed entries match.
  - number: 31
    conditions:
    - condition_type: FUNFAM
      value: 1.10.132.130:FF:000002
      curie: CATH.FunFam:1.10.132.130:FF:000002
      label: Legumain preproprotein
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000006
      curie: CATH.FunFam:3.40.50.1460:FF:000006
      label: Legumain
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 307 unreviewed entries match.
  - number: 32
    conditions:
    - condition_type: FUNFAM
      value: 1.10.150.420:FF:000001
      curie: CATH.FunFam:1.10.150.420:FF:000001
      label: Replicase polyprotein
      negated: false
    - condition_type: FUNFAM
      value: 1.10.1840.10:FF:000001
      curie: CATH.FunFam:1.10.1840.10:FF:000001
      label: Replicase polyprotein 1a
      negated: false
    - condition_type: FUNFAM
      value: 1.10.8.370:FF:000001
      curie: CATH.FunFam:1.10.8.370:FF:000001
      label: Orf1a polyprotein
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 284 unreviewed entries match.
  - number: 33
    conditions:
    - condition_type: FUNFAM
      value: 1.10.238.10:FF:000099
      curie: CATH.FunFam:1.10.238.10:FF:000099
      label: calpain-2 catalytic subunit
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.380:FF:000001
      curie: CATH.FunFam:2.60.120.380:FF:000001
      label: Calpain-1 catalytic subunit
      negated: false
    - condition_type: TAXON
      value: Mammalia
      curie: NCBITaxon:40674
      label: Mammalia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or
      a descendant, 10 of those by a manual-evidence GO annotation. 338 unreviewed entries match.
  - number: 34
    conditions:
    - condition_type: FUNFAM
      value: 1.10.238.10:FF:000124
      curie: CATH.FunFam:1.10.238.10:FF:000124
      label: Calpain-1 catalytic subunit
      negated: false
    - condition_type: FUNFAM
      value: 3.90.70.10:FF:000001
      curie: CATH.FunFam:3.90.70.10:FF:000001
      label: Calpain-1 catalytic subunit
      negated: false
    - condition_type: TAXON
      value: Craniata
      curie: NCBITaxon:89593
      label: Craniata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 1004 unreviewed entries match.
  - number: 35
    conditions:
    - condition_type: FUNFAM
      value: 2.10.220.10:FF:000023
      curie: CATH.FunFam:2.10.220.10:FF:000023
      label: Furin, paired basic amino acid cleaving enzyme
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000034
      curie: CATH.FunFam:2.60.120.260:FF:000034
      label: furin isoform X2
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.850:FF:000001
      curie: CATH.FunFam:3.30.70.850:FF:000001
      label: Proprotein convertase subtilisin/kexin type 5
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 178 unreviewed entries match.
  - number: 36
    conditions:
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000016
      curie: CATH.FunFam:2.10.70.10:FF:000016
      label: Mannan-binding lectin serine protease 1
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000006
      curie: CATH.FunFam:2.60.120.290:FF:000006
      label: Mannan-binding lectin serine protease 1
      negated: false
    - condition_type: TAXON
      value: Haplorrhini
      curie: NCBITaxon:376913
      label: Haplorrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 234 unreviewed entries match.
  - number: 37
    conditions:
    - condition_type: FUNFAM
      value: 2.20.100.10:FF:000005
      curie: CATH.FunFam:2.20.100.10:FF:000005
      label: ADAM metallopeptidase with thrombospondin type 1 motif 9
      negated: false
    - condition_type: FUNFAM
      value: 2.20.100.10:FF:000006
      curie: CATH.FunFam:2.20.100.10:FF:000006
      label: A disintegrin and metalloproteinase with thrombospondin motifs 1
      negated: false
    - condition_type: TAXON
      value: Mus
      curie: NCBITaxon:10088
      label: Mus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 27 unreviewed entries match.
  - number: 38
    conditions:
    - condition_type: FUNFAM
      value: 3.40.390.10:FF:000011
      curie: CATH.FunFam:3.40.390.10:FF:000011
      label: Disintegrin and metalloproteinase domain-containing protein 10
      negated: false
    - condition_type: FUNFAM
      value: 4.10.70.10:FF:000002
      curie: CATH.FunFam:4.10.70.10:FF:000002
      label: disintegrin and metalloproteinase domain-containing protein 10
      negated: false
    - condition_type: TAXON
      value: Vertebrata
      curie: NCBITaxon:7742
      label: Vertebrata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 1667 unreviewed entries match.
  - number: 39
    conditions:
    - condition_type: FUNFAM
      value: 1.10.533.10:FF:000073
      curie: CATH.FunFam:1.10.533.10:FF:000073
      label: Inactive caspase-12
      negated: false
    - condition_type: TAXON
      value: Euteleostomi
      curie: NCBITaxon:117571
      label: Euteleostomi
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 83 unreviewed entries match.
  - number: 40
    conditions:
    - condition_type: FUNFAM
      value: 2.10.109.10:FF:000003
      curie: CATH.FunFam:2.10.109.10:FF:000003
      label: Signal peptidase complex catalytic subunit SEC11
      negated: false
    - condition_type: TAXON
      value: Eutheria
      curie: NCBITaxon:9347
      label: Eutheria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 11 reviewed entries match this set; 11 of them carry GO:0004175 or
      a descendant, 11 of those by a manual-evidence GO annotation. 563 unreviewed entries match.
  - number: 41
    conditions:
    - condition_type: FUNFAM
      value: 2.70.70.10:FF:000002
      curie: CATH.FunFam:2.70.70.10:FF:000002
      label: Murein DD-endopeptidase MepM
      negated: false
    - condition_type: TAXON
      value: Gammaproteobacteria
      curie: NCBITaxon:1236
      label: Gammaproteobacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 2873 unreviewed entries match.
  - number: 42
    conditions:
    - condition_type: FUNFAM
      value: 3.60.20.10:FF:000004
      curie: CATH.FunFam:3.60.20.10:FF:000004
      label: Proteasome subunit alpha type-4
      negated: false
    - condition_type: TAXON
      value: Archaea
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: >-
      UniProtKB release 2026_04: 48 reviewed entries match this set; 48 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 766 unreviewed entries match.
  - number: 43
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000022
      curie: CATH.FunFam:2.10.25.10:FF:000022
      label: Metalloendopeptidase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000004
      curie: CATH.FunFam:2.60.120.290:FF:000004
      label: Metalloendopeptidase
      negated: false
    - condition_type: TAXON
      value: Catarrhini
      curie: NCBITaxon:9526
      label: Catarrhini
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 96 unreviewed entries match.
  - number: 44
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000059
      curie: CATH.FunFam:2.10.25.10:FF:000059
      label: Mannan-binding lectin serine protease 1
      negated: false
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000028
      curie: CATH.FunFam:2.10.70.10:FF:000028
      label: mannan-binding lectin serine protease 1 isoform X2
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000015
      curie: CATH.FunFam:2.40.10.10:FF:000015
      label: Atrial natriuretic peptide-converting enzyme
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 142 unreviewed entries match.
  - number: 45
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000483
      curie: CATH.FunFam:2.10.25.10:FF:000483
      label: Tissue-type plasminogen activator
      negated: false
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000043
      curie: CATH.FunFam:2.10.70.10:FF:000043
      label: Plasminogen activator
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000054
      curie: CATH.FunFam:2.40.10.10:FF:000054
      label: Complement C1r subcomponent
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 108 unreviewed entries match.
  - number: 46
    conditions:
    - condition_type: FUNFAM
      value: 2.10.70.10:FF:000045
      curie: CATH.FunFam:2.10.70.10:FF:000045
      label: Pappalysin 1
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.200:FF:000097
      curie: CATH.FunFam:2.60.120.200:FF:000097
      label: Pappalysin 1
      negated: false
    - condition_type: FUNFAM
      value: 3.40.390.10:FF:000026
      curie: CATH.FunFam:3.40.390.10:FF:000026
      label: Pappalysin 1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 732 unreviewed entries match.
  - number: 47
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000004
      curie: CATH.FunFam:2.40.70.10:FF:000004
      label: Pepsin A
      negated: false
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000006
      curie: CATH.FunFam:2.40.70.10:FF:000006
      label: Cathepsin E
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: >-
      UniProtKB release 2026_04: 14 reviewed entries match this set; 14 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 140 unreviewed entries match.
  - number: 48
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000011
      curie: CATH.FunFam:2.40.70.10:FF:000011
      label: Aspartic protease
      negated: false
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000023
      curie: CATH.FunFam:2.40.70.10:FF:000023
      label: Aspartic protease
      negated: false
    - condition_type: TAXON
      value: Saccharomycetes
      curie: NCBITaxon:4891
      label: Saccharomycetes
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 51 unreviewed entries match.
  - number: 49
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000024
      curie: CATH.FunFam:2.40.70.10:FF:000024
      label: Endothiapepsin
      negated: false
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000026
      curie: CATH.FunFam:2.40.70.10:FF:000026
      label: Endothiapepsin
      negated: false
    - condition_type: TAXON
      value: Penicillium
      curie: NCBITaxon:5073
      label: Penicillium
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 134 unreviewed entries match.
  - number: 50
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.2310:FF:000001
      curie: CATH.FunFam:2.60.40.2310:FF:000001
      label: Subtilisin-like protease SBT1.5
      negated: false
    - condition_type: FUNFAM
      value: 3.30.70.80:FF:000002
      curie: CATH.FunFam:3.30.70.80:FF:000002
      label: Subtilisin-like protease SBT5.3
      negated: false
    - condition_type: FUNFAM
      value: 3.50.30.30:FF:000005
      curie: CATH.FunFam:3.50.30.30:FF:000005
      label: subtilisin-like protease SBT1.5
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 380 unreviewed entries match.
  - number: 51
    conditions:
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000003
      curie: CATH.FunFam:3.30.830.10:FF:000003
      label: Insulin-degrading enzyme
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000004
      curie: CATH.FunFam:3.30.830.10:FF:000004
      label: Putative insulin-degrading enzyme
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000006
      curie: CATH.FunFam:3.30.830.10:FF:000006
      label: Putative insulin-degrading enzyme
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 1195 unreviewed entries match.
  - number: 52
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000005
      curie: CATH.FunFam:2.40.10.10:FF:000005
      label: Serine protease 37
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000014
      curie: CATH.FunFam:2.40.10.10:FF:000014
      label: Complement factor D
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 361 unreviewed entries match.
  - number: 53
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000120
      curie: CATH.FunFam:2.40.10.10:FF:000120
      label: Putative serine protease
      negated: false
    - condition_type: TAXON
      value: Rattus
      curie: NCBITaxon:10114
      label: Rattus
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 5 unreviewed entries match.
  - number: 54
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.12660:FF:000010
      curie: CATH.FunFam:3.40.50.12660:FF:000010
      label: Metacaspase-9
      negated: false
    - condition_type: TAXON
      value: Streptophyta
      curie: NCBITaxon:35493
      label: Streptophyta
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 36 unreviewed entries match.
  - number: 55
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1820:FF:000005
      curie: CATH.FunFam:3.40.50.1820:FF:000005
      label: Prolyl endopeptidase
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 289 unreviewed entries match.
  - number: 56
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000001
      curie: CATH.FunFam:3.40.50.200:FF:000001
      label: Furin 2, isoform B
      negated: false
    - condition_type: TAXON
      value: Arthropoda
      curie: NCBITaxon:6656
      label: Arthropoda
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 930 unreviewed entries match.
  - number: 57
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000055
      curie: CATH.FunFam:3.40.50.200:FF:000055
      label: Tk-subtilisin
      negated: false
    - condition_type: TAXON
      value: Bacilli
      curie: NCBITaxon:91061
      label: Bacilli
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 31 unreviewed entries match.
  - number: 58
    conditions:
    - condition_type: FUNFAM
      value: 3.60.20.10:FF:000023
      curie: CATH.FunFam:3.60.20.10:FF:000023
      label: Proteasome subunit alpha
      negated: false
    - condition_type: TAXON
      value: Actinomycetota
      curie: NCBITaxon:201174
      label: Actinomycetota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 29 reviewed entries match this set; 29 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 1099 unreviewed entries match.
  - number: 59
    conditions:
    - condition_type: FUNFAM
      value: 3.60.20.10:FF:000046
      curie: CATH.FunFam:3.60.20.10:FF:000046
      label: Proteasome subunit beta
      negated: false
    - condition_type: TAXON
      value: Actinomycetes
      curie: NCBITaxon:1760
      label: Actinomycetes
      negated: false
    notes: >-
      UniProtKB release 2026_04: 31 reviewed entries match this set; 31 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 1199 unreviewed entries match.
  - number: 60
    conditions:
    - condition_type: FUNFAM
      value: 3.60.20.10:FF:000049
      curie: CATH.FunFam:3.60.20.10:FF:000049
      label: Proteasome subunit beta
      negated: false
    - condition_type: TAXON
      value: Methanobacteriati
      curie: NCBITaxon:3366610
      label: Methanobacteriati
      negated: false
    notes: >-
      UniProtKB release 2026_04: 53 reviewed entries match this set; 53 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 314 unreviewed entries match.
  - number: 61
    conditions:
    - condition_type: FUNFAM
      value: 3.90.70.10:FF:000081
      curie: CATH.FunFam:3.90.70.10:FF:000081
      label: cathepsin B-like protease 2
      negated: false
    - condition_type: TAXON
      value: Embryophyta
      curie: NCBITaxon:3193
      label: Embryophyta
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 699 unreviewed entries match.
  - number: 62
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000041
      curie: CATH.FunFam:2.40.10.10:FF:000041
      label: kallikrein-6 isoform X2
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 266 unreviewed entries match.
  - number: 63
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000066
      curie: CATH.FunFam:2.40.70.10:FF:000066
      label: Napsin A aspartic peptidase
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 1167 unreviewed entries match.
  - number: 64
    conditions:
    - condition_type: FUNFAM
      value: 3.30.2010.10:FF:000009
      curie: CATH.FunFam:3.30.2010.10:FF:000009
      label: metalloendopeptidase OMA1, mitochondrial isoform X1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or
      a descendant, 4 of those by a manual-evidence GO annotation. 247 unreviewed entries match.
  - number: 65
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000008
      curie: CATH.FunFam:3.40.50.1460:FF:000008
      label: caspase-8 isoform X1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 1890 unreviewed entries match.
  - number: 66
    conditions:
    - condition_type: FUNFAM
      value: 1.10.132.130:FF:000001
      curie: CATH.FunFam:1.10.132.130:FF:000001
      label: Vacuolar-processing enzyme beta-isozyme
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000005
      curie: CATH.FunFam:3.40.50.1460:FF:000005
      label: Vacuolar-processing enzyme beta-isozyme
      negated: false
    - condition_type: TAXON
      value: Liliopsida
      curie: NCBITaxon:4447
      label: Liliopsida
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 452 unreviewed entries match.
  - number: 67
    conditions:
    - condition_type: FUNFAM
      value: 1.10.2000.10:FF:000011
      curie: CATH.FunFam:1.10.2000.10:FF:000011
      label: Corin, serine peptidase
      negated: false
    - condition_type: FUNFAM
      value: 1.10.2000.10:FF:000013
      curie: CATH.FunFam:1.10.2000.10:FF:000013
      label: atrial natriuretic peptide-converting enzyme
      negated: false
    - condition_type: FUNFAM
      value: 4.10.400.10:FF:000024
      curie: CATH.FunFam:4.10.400.10:FF:000024
      label: Low-density lipoprotein RecePtor related
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 318 unreviewed entries match.
  - number: 68
    conditions:
    - condition_type: FUNFAM
      value: 1.10.238.10:FF:000065
      curie: CATH.FunFam:1.10.238.10:FF:000065
      label: calpain-3 isoform X1
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.380:FF:000002
      curie: CATH.FunFam:2.60.120.380:FF:000002
      label: calpain-3 isoform X1
      negated: false
    - condition_type: TAXON
      value: Rodentia
      curie: NCBITaxon:9989
      label: Rodentia
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 72 unreviewed entries match.
  - number: 69
    conditions:
    - condition_type: FUNFAM
      value: 2.20.100.10:FF:000009
      curie: CATH.FunFam:2.20.100.10:FF:000009
      label: ADAMTS-like protein 3 isoform A
      negated: false
    - condition_type: FUNFAM
      value: 2.60.120.830:FF:000003
      curie: CATH.FunFam:2.60.120.830:FF:000003
      label: ADAM metallopeptidase with thrombospondin type 1 motif 13
      negated: false
    - condition_type: FUNFAM
      value: 3.40.1620.60:FF:000001
      curie: CATH.FunFam:3.40.1620.60:FF:000001
      label: A disintegrin and metalloproteinase with thrombospondin motifs 3
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 39 unreviewed entries match.
  - number: 70
    conditions:
    - condition_type: FUNFAM
      value: 2.30.42.10:FF:000037
      curie: CATH.FunFam:2.30.42.10:FF:000037
      label: Periplasmic serine endoprotease DegP-like
      negated: false
    - condition_type: FUNFAM
      value: 2.30.42.10:FF:000050
      curie: CATH.FunFam:2.30.42.10:FF:000050
      label: Periplasmic serine endoprotease DegP-like
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.120:FF:000001
      curie: CATH.FunFam:2.40.10.120:FF:000001
      label: Periplasmic serine endoprotease DegP-like
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 963 unreviewed entries match.
  - number: 71
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000028
      curie: CATH.FunFam:2.40.10.10:FF:000028
      label: Serine protease easter
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000084
      curie: CATH.FunFam:2.40.10.10:FF:000084
      label: Serine protease easter
      negated: false
    - condition_type: FUNFAM
      value: 3.30.1640.30:FF:000002
      curie: CATH.FunFam:3.30.1640.30:FF:000002
      label: Spaetzle-processing enzyme
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 19 unreviewed entries match.
  - number: 72
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000118
      curie: CATH.FunFam:2.40.10.10:FF:000118
      label: Chymotrypsinogen A
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000176
      curie: CATH.FunFam:2.40.10.10:FF:000176
      label: Chymotrypsinogen A
      negated: false
    - condition_type: TAXON
      value: Muroidea
      curie: NCBITaxon:337687
      label: Muroidea
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 17 unreviewed entries match.
  - number: 73
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000016
      curie: CATH.FunFam:2.40.70.10:FF:000016
      label: Probable aspartic protease At2g35615
      negated: false
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000050
      curie: CATH.FunFam:2.40.70.10:FF:000050
      label: Aspartic proteinase CDR1
      negated: false
    - condition_type: TAXON
      value: Tracheophyta
      curie: NCBITaxon:58023
      label: Tracheophyta
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1290 unreviewed entries match.
  - number: 74
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000039
      curie: CATH.FunFam:2.40.70.10:FF:000039
      label: Cathepsin D preproprotein
      negated: false
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000047
      curie: CATH.FunFam:2.40.70.10:FF:000047
      label: Cathepsin D preproprotein
      negated: false
    - condition_type: TAXON
      value: Muridae
      curie: NCBITaxon:10066
      label: Muridae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 21 unreviewed entries match.
  - number: 75
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000026
      curie: CATH.FunFam:2.60.120.260:FF:000026
      label: proprotein convertase subtilisin/kexin type 7
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000005
      curie: CATH.FunFam:3.40.50.200:FF:000005
      label: Proprotein convertase subtilisin/kexin type 7
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 1394 unreviewed entries match.
  - number: 76
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000054
      curie: CATH.FunFam:2.60.120.260:FF:000054
      label: Proprotein convertase subtilisin/kexin type 1
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000010
      curie: CATH.FunFam:3.40.50.200:FF:000010
      label: Putative neuroendocrine convertase 1
      negated: false
    - condition_type: TAXON
      value: Murinae
      curie: NCBITaxon:39107
      label: Murinae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 4 unreviewed entries match.
  - number: 77
    conditions:
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000001
      curie: CATH.FunFam:3.30.830.10:FF:000001
      label: Mitochondrial-processing peptidase subunit beta, mitochondrial
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000002
      curie: CATH.FunFam:3.30.830.10:FF:000002
      label: Mitochondrial-processing peptidase subunit beta
      negated: false
    - condition_type: TAXON
      value: Ascomycota
      curie: NCBITaxon:4890
      label: Ascomycota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 949 unreviewed entries match.
  - number: 78
    conditions:
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000024
      curie: CATH.FunFam:3.30.830.10:FF:000024
      label: Stromal processing peptidase chloroplastic
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000025
      curie: CATH.FunFam:3.30.830.10:FF:000025
      label: Stromal processing peptidase chloroplastic
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000033
      curie: CATH.FunFam:3.30.830.10:FF:000033
      label: Stromal processing peptidase, chloroplastic
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 234 unreviewed entries match.
  - number: 79
    conditions:
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000053
      curie: CATH.FunFam:3.30.830.10:FF:000053
      label: Falcilysin
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000054
      curie: CATH.FunFam:3.30.830.10:FF:000054
      label: Falcilysin
      negated: false
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000056
      curie: CATH.FunFam:3.30.830.10:FF:000056
      label: Falcilysin
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 0 unreviewed entries match.
  - number: 80
    conditions:
    - condition_type: FUNFAM
      value: 1.10.238.10:FF:000241
      curie: CATH.FunFam:1.10.238.10:FF:000241
      label: Calpain-A, isoform C
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 267 unreviewed entries match.
  - number: 81
    conditions:
    - condition_type: FUNFAM
      value: 1.10.533.10:FF:000041
      curie: CATH.FunFam:1.10.533.10:FF:000041
      label: Caspase 9
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000012
      curie: CATH.FunFam:3.40.50.1460:FF:000012
      label: Caspase 9
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 303 unreviewed entries match.
  - number: 82
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1070.10:FF:000352
      curie: CATH.FunFam:1.20.1070.10:FF:000352
      label: Latrophilin-like protein 1
      negated: false
    - condition_type: TAXON
      value: Nematoda
      curie: NCBITaxon:6231
      label: Nematoda
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 97 unreviewed entries match.
  - number: 83
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1120.10:FF:000002
      curie: CATH.FunFam:1.20.1120.10:FF:000002
      label: Botulinum neurotoxin type D
      negated: false
    - condition_type: TAXON
      value: Duplodnaviria
      curie: NCBITaxon:2731341
      label: Duplodnaviria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.
  - number: 84
    conditions:
    - condition_type: FUNFAM
      value: 2.10.25.10:FF:000259
      curie: CATH.FunFam:2.10.25.10:FF:000259
      label: Coagulation factor VII
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000003
      curie: CATH.FunFam:2.40.10.10:FF:000003
      label: Transmembrane serine protease 3
      negated: false
    notes: >-
      UniProtKB release 2026_04: 6 reviewed entries match this set; 6 of them carry GO:0004175 or
      a descendant, 6 of those by a manual-evidence GO annotation. 178 unreviewed entries match.
  - number: 85
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000122
      curie: CATH.FunFam:2.40.10.10:FF:000122
      label: Chymotrypsin-like elastase family member 1
      negated: false
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000280
      curie: CATH.FunFam:2.40.10.10:FF:000280
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0004175 or
      a descendant, 8 of those by a manual-evidence GO annotation. 736 unreviewed entries match.
  - number: 86
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000082
      curie: CATH.FunFam:2.40.70.10:FF:000082
      label: Plasmepsin X
      negated: false
    - condition_type: TAXON
      value: Sar
      curie: NCBITaxon:2698737
      label: Sar
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 10 unreviewed entries match.
  - number: 87
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.290:FF:000052
      curie: CATH.FunFam:2.60.120.290:FF:000052
      label: Metalloendopeptidase
      negated: false
    - condition_type: TAXON
      value: Allotriocarida
      curie: NCBITaxon:3701030
      label: Allotriocarida
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 322 unreviewed entries match.
  - number: 88
    conditions:
    - condition_type: FUNFAM
      value: 3.30.70.1470:FF:000002
      curie: CATH.FunFam:3.30.70.1470:FF:000002
      label: Caspase-3
      negated: false
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000011
      curie: CATH.FunFam:3.40.50.1460:FF:000011
      label: Caspase-7
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 365 unreviewed entries match.
  - number: 89
    conditions:
    - condition_type: FUNFAM
      value: 3.40.1620.60:FF:000006
      curie: CATH.FunFam:3.40.1620.60:FF:000006
      label: A disintegrin and metalloproteinase with thrombospondin motifs 5
      negated: false
    - condition_type: FUNFAM
      value: 3.40.390.10:FF:000001
      curie: CATH.FunFam:3.40.390.10:FF:000001
      label: A disintegrin and metalloproteinase with thrombospondin motifs 1
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 478 unreviewed entries match.
  - number: 90
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000001
      curie: CATH.FunFam:3.40.50.1460:FF:000001
      label: Caspase-3 preproprotein
      negated: false
    - condition_type: TAXON
      value: Archelosauria
      curie: NCBITaxon:1329799
      label: Archelosauria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 703 unreviewed entries match.
  - number: 91
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.1460:FF:000031
      curie: CATH.FunFam:3.40.50.1460:FF:000031
      label: Gingipain R2
      negated: false
    - condition_type: TAXON
      value: Pseudomonadati
      curie: NCBITaxon:3379134
      label: Pseudomonadati
      negated: false
    notes: >-
      UniProtKB release 2026_04: 4 reviewed entries match this set; 4 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.
  - number: 92
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000007
      curie: CATH.FunFam:3.40.50.200:FF:000007
      label: Subtilisin-like serine protease
      negated: false
    - condition_type: TAXON
      value: Taphrinomycotina
      curie: NCBITaxon:451866
      label: Taphrinomycotina
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 20 unreviewed entries match.
  - number: 93
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.200:FF:000023
      curie: CATH.FunFam:3.40.50.200:FF:000023
      label: Subtilisin-like protease 1
      negated: false
    - condition_type: TAXON
      value: Alveolata
      curie: NCBITaxon:33630
      label: Alveolata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1 unreviewed entries match.
  - number: 94
    conditions:
    - condition_type: FUNFAM
      value: 3.90.70.10:FF:000005
      curie: CATH.FunFam:3.90.70.10:FF:000005
      label: Ubiquitin carboxyl-terminal hydrolase 7
      negated: false
    - condition_type: TAXON
      value: Schizosaccharomycetes
      curie: NCBITaxon:147554
      label: Schizosaccharomycetes
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 7 unreviewed entries match.
  - number: 95
    conditions:
    - condition_type: FUNFAM
      value: 3.90.70.10:FF:000039
      curie: CATH.FunFam:3.90.70.10:FF:000039
      label: Cysteine proteinase 2, putative
      negated: false
    - condition_type: TAXON
      value: Archamoebae
      curie: NCBITaxon:555406
      label: Archamoebae
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 122 unreviewed entries match.
  - number: 96
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1540.10:FF:000012
      curie: CATH.FunFam:1.20.1540.10:FF:000012
      label: Rhomboid family protein
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 690 unreviewed entries match.
  - number: 97
    conditions:
    - condition_type: FUNFAM
      value: 2.10.109.10:FF:000005
      curie: CATH.FunFam:2.10.109.10:FF:000005
      label: Mitochondrial inner membrane protease subunit
      negated: false
    notes: >-
      UniProtKB release 2026_04: 7 reviewed entries match this set; 7 of them carry GO:0004175 or
      a descendant, 7 of those by a manual-evidence GO annotation. 1406 unreviewed entries match.
  - number: 98
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000047
      curie: CATH.FunFam:2.40.10.10:FF:000047
      label: Trypsin eta
      negated: false
    notes: >-
      UniProtKB release 2026_04: 16 reviewed entries match this set; 16 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 3505 unreviewed entries match.
  - number: 99
    conditions:
    - condition_type: FUNFAM
      value: 2.40.10.10:FF:000080
      curie: CATH.FunFam:2.40.10.10:FF:000080
      label: peroxisomal leader peptide-processing protease
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 360 unreviewed entries match.
  - number: 100
    conditions:
    - condition_type: FUNFAM
      value: 2.40.70.10:FF:000043
      curie: CATH.FunFam:2.40.70.10:FF:000043
      label: retroviral-like aspartic protease 1 isoform X3
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 122 unreviewed entries match.
  - number: 101
    conditions:
    - condition_type: FUNFAM
      value: 3.30.2010.10:FF:000003
      curie: CATH.FunFam:3.30.2010.10:FF:000003
      label: CAAX prenyl protease
      negated: false
    notes: >-
      UniProtKB release 2026_04: 2 reviewed entries match this set; 2 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 1163 unreviewed entries match.
  - number: 102
    conditions:
    - condition_type: FUNFAM
      value: 3.30.2010.10:FF:000005
      curie: CATH.FunFam:3.30.2010.10:FF:000005
      label: CAAX prenyl protease
      negated: false
    notes: >-
      UniProtKB release 2026_04: 3 reviewed entries match this set; 3 of them carry GO:0004175 or
      a descendant, 3 of those by a manual-evidence GO annotation. 616 unreviewed entries match.
  - number: 103
    conditions:
    - condition_type: FUNFAM
      value: 3.30.830.10:FF:000012
      curie: CATH.FunFam:3.30.830.10:FF:000012
      label: Protease 3
      negated: false
    notes: >-
      UniProtKB release 2026_04: 10 reviewed entries match this set; 10 of them carry GO:0004175 or
      a descendant, 5 of those by a manual-evidence GO annotation. 3423 unreviewed entries match.
  - number: 104
    conditions:
    - condition_type: FUNFAM
      value: 3.40.50.12660:FF:000005
      curie: CATH.FunFam:3.40.50.12660:FF:000005
      label: Mca1p
      negated: false
    notes: >-
      UniProtKB release 2026_04: 5 reviewed entries match this set; 5 of them carry GO:0004175 or
      a descendant, 2 of those by a manual-evidence GO annotation. 42 unreviewed entries match.
  go_annotations:
  - go_id: GO:0004175
    go_label: endopeptidase activity
    aspect: MF
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 104
review_summary: >-
  All 104 live condition sets were checked against Swiss-Prot. They match 1063 reviewed entries in
  total and every one carries GO:0004175 or a descendant, 630 by manual evidence. One set is weakly
  founded: set 14 is the single InterPro entry IPR003675, which matches 56399 unreviewed entries.
  Of its 40 reviewed matches only 10, all CAAX prenyl protease 2 orthologues, have a manual annotation;
  the other 30, which include lysostaphin resistance protein A and proteins named as uncharacterised,
  carry the term only from this rule.
action: MODIFY
action_rationale: >-
  Set 14 extends an activity shown for CAAX prenyl protease 2 to a whole domain family whose other
  reviewed members have no independent support for it. The set should be narrowed to the characterised
  subfamily. No defect was found in the other 103 sets, which were checked by counts only. The counts
  are from Swiss-Prot, which is also what ARBA learns its rules from, so they show the condition sets
  are coherent rather than giving an independent error rate for unreviewed entries.
suggested_modifications:
- >-
  Narrow condition set 14 (IPR003675 alone) to CAAX prenyl protease 2 proteins by adding a family-level
  condition, or remove it until the bacterial members have evidence of endopeptidase activity.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0004175
  label: endopeptidase activity
  assessment: UNDECIDED
  matched_protein_count: 1063
  correct_examples:
  - Q9Y256
  - Q8GW19
  - Q6LZY8
  - G5EDW2
  - Q9UTT1
  notes: >-
    UniProtKB release 2026_04: set 14 matches 40 reviewed and 56399 unreviewed entries. Manual annotations
    to GO:0004175 in set 14 (QuickGO, retrieved 2026-11-09): Q9Y256 (human RCE1), IDA, PMID:19188362;
    Q8GW19 (Arabidopsis FACE2), IDA, PMID:12928436; Q6LZY8 (Methanococcus maripaludis rce1), IDA,
    PMID:24291792. Reviewed matches of set 14 whose only annotation to the term is IEA, GO_REF:0000117:
    Q2FVT1 (Staphylococcus aureus lyrA), P50730 (Bacillus subtilis ypbD, Uncharacterized protein YpbD),
    Q9CDG9 (Lactococcus lactis yxdF, UPF0177 protein YxdF). These are unsupported, not shown to be
    wrong. Other sets with unusual families are supported: set 82, G5EDW2 (Caenorhabditis elegans
    lat-1), IDA, PMID:22938866; set 94, Q9UTT1 (Schizosaccharomyces pombe ubp15), IDA, PMID:28947618.
confidence: 0.55
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    The rule uses IPR001096 for papain-type cysteine proteases, IPR003675 for subtilisin-type serine
    proteases and IPR001915 for aminopeptidase-type metalloproteases.
  correction: >-
    All three identifiers were given the names of other families. IPR001096 is Peptidase C13, legumain;
    IPR003675 is the CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain; IPR001915
    is Peptidase M48. None is an aminopeptidase family, and aminopeptidases would not be endopeptidases.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - >-
    InterPro API: IPR001096 name Peptidase C13, legumain; IPR003675 name CAAX prenyl protease 2/Lysostaphin
    resistance protein A-like domain; IPR001915 name Peptidase M48.
- date: '2026-11-10'
  withdrawn_claim: The GO term is biologically correct for all covered proteins.
  correction: >-
    The condition sets had not been recorded and the families were misidentified, so this had not
    been checked. It holds for reviewed matches by count, with the reservation on set 14.
  error_type: UNEXAMINED_RULE
  evidence:
  - The old file recorded condition_sets as an empty list.
  - >-
    UniProtKB release 2026_04: 30 of the 40 reviewed matches of set 14 have no manual annotation to
    GO:0004175 or a descendant.
- date: '2026-11-10'
  withdrawn_claim: >-
    More specific terms should be used: GO:0004194 for aspartic proteases, GO:0008234 for cysteine
    proteases and GO:0008237 for metalloproteases.
  correction: >-
    GO:0004194 is obsolete. GO:0008234 and GO:0008237 are not descendants of the rule term; they cover
    exopeptidases as well, so they are not refinements of it.
  error_type: ONTOLOGY_MISREAD
  evidence:
  - 'QuickGO: GO:0004194 is obsolete (obsolete pepsin A activity).'
  - QuickGO ancestors of GO:0008234 and of GO:0008237 do not include GO:0004175.
- date: '2026-11-10'
  withdrawn_claim: >-
    With 41 condition sets the rule is a maintenance burden and should be decomposed into rules of
    fewer than 20 sets.
  correction: >-
    The number of sets is not evidence about accuracy. All 104 live sets were checked against Swiss-Prot.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'UniProt ARBA API, ARBA00028131, retrieved 2026-11-09: 104 condition sets.'
- date: '2026-11-10'
  withdrawn_claim: >-
    Literature support was shown by quotations from the review's own research and citation notes.
  correction: Those files are the review's own notes, not publications, and are no longer cited.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    The old supported_by entries cited rules/arba/ARBA00028131/ARBA00028131-deep-research-manual.md
    and ARBA00028131-citations.md only.