View original ARBA rule on UniProt
Assigns GO:0010468 regulation of gene expression through 929 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition.
Condition-set counts describe the sets recorded in this review, which may omit the full rule.
No domain overlap table is shown: the cached overlap analysis for this version of the review is not available.
Run just analyze-rule ARBA00028334 and re-render to add it.
None of the 929 live condition sets has been examined, and no wrongly annotated protein has been identified. The review is open.
There is no evidence in hand for or against the rule's correctness. That the term is general is not a reason to deprecate.
No condition set examined.
id: ARBA00028334
description: Assigns GO:0010468 regulation of gene expression through 929 alternative condition sets of
InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition.
status: IN_PROGRESS
rule_type: ARBA
rule:
rule_id: ARBA00028334
condition_sets: []
go_annotations:
- go_id: GO:0010468
go_label: regulation of gene expression
aspect: BP
entries: []
reviewed_protein_count: 0
unreviewed_protein_count: 0
created_date: '2021-10-20'
modified_date: '2026-07-18'
retrieved_date: '2026-11-09'
source_condition_set_count: 929
review_summary: None of the 929 live condition sets has been examined, and no wrongly annotated protein
has been identified. The review is open.
action: UNDECIDED
action_rationale: There is no evidence in hand for or against the rule's correctness. That the term is
general is not a reason to deprecate.
annotation_assessments:
- annotation_kind: GO_TERM
value: GO:0010468
label: regulation of gene expression
assessment: UNDECIDED
notes: No condition set examined.
corrections:
- date: '2026-11-10'
withdrawn_claim: The rule is fundamentally flawed and should be deprecated (confidence 0.95).
correction: No condition set and no annotated protein was examined, so the verdict had no evidence about
the rule's content.
error_type: UNEXAMINED_RULE
evidence:
- 'Old review: rule.condition_sets empty, protein counts 0, dates "unknown"'
- date: '2026-11-10'
withdrawn_claim: 930 condition sets with 267 InterPro domains is unmaintainable complexity; rules should
have fewer than 12 sets.
correction: The number of alternative sets is not evidence that any of them is wrong.
error_type: SIZE_AS_EVIDENCE
evidence:
- 'src/ai_gene_review/etl/rule_analysis.py: max_condition_sets: int = 12 (default of the overlap-analysis
tool)'
- date: '2026-11-10'
withdrawn_claim: GO:0010468 is too broad to be useful, so the rule should be deprecated.
correction: A true general term is not grounds for removal.
error_type: GENERAL_IS_NOT_WRONG
evidence:
- 'QuickGO: GO:0010468 regulation of gene expression is a current, non-obsolete term'
- date: '2026-11-10'
withdrawn_claim: Spanning 134 taxonomic groups shows indiscriminate application across all life.
correction: Taxon conditions restrict where each set fires; many different taxa means many restricted
sets.
error_type: TAXON_MISREAD
evidence:
- 'Live rule: 929 sets, each a conjunction (rest.uniprot.org/arba/ARBA00028334, 2026-11-09)'
- date: '2026-11-10'
withdrawn_claim: Literature support is NONE, supported by references "analysis:complexity", "analysis:domain_diversity",
"analysis:taxonomic_distribution" and "analysis:rule_structure".
correction: These are not sources. No literature search was made, which is not the same as finding no
support.
error_type: UNSUPPORTED_SOURCE
evidence:
- 'Old review literature_support notes: "No comprehensive literature search is possible"'