ARBA00028665 cell development (GO:0048468)

View original ARBA rule on UniProt

Type: ARBA
Status: IN_PROGRESS
Action: UNDECIDED

Description

Assigns GO:0048468 (cell development) through 392 alternative condition sets. Every set is a conjunction of one to three InterPro entries, PANTHER families or CATH FunFams with a taxon.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0
Domain Pairs Analyzed
10
Recorded condition sets
0
Subset Relationships
0
Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00028665 and re-render to add it.

Review Summary

The first 10 of the 392 live condition sets were examined. Six match reviewed entries, and 78 of 79 of those entries carry GO:0048468 or a descendant, 48 by manual evidence. Four of the ten repeat the conditions of a neighbouring set for Archaea or Bacteria and match no UniProtKB entry. The other 382 sets were not examined.

Action Rationale

The rule was sampled, not examined set by set, so no verdict is given. The sampled sets are sound, which removes the grounds of the earlier verdict but does not establish that every set is right. The counts are from Swiss-Prot, which is also what ARBA learns its rules from, so they show the condition sets are coherent rather than giving an independent error rate for unreviewed entries.

GO Annotations

GO:0048468 - cell development
Aspect: BP

Annotation Assessments

UNDECIDED GO_TERM GO:0048468 - cell development
Matched proteins: ; incorrect:
Correct examples: Q9VQ30, Q8IN81, Q24174

UniProtKB release 2026_04: set 2 reviewed matches with a manual-evidence annotation to GO:0048468 or a descendant include Q9VQ30 (Drosophila chinmo), Q8IN81 (fru) and Q24174 (ab). Per-set counts are in the condition set notes.

Rule Definition

Condition Sets

Condition Set 1

4 condition(s)
Notes:

UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.

Condition Set 2

4 condition(s)
Notes:

UniProtKB release 2026_04: 13 reviewed entries match this set; 13 of them carry GO:0048468 or a descendant, 13 of those by a manual-evidence GO annotation. 6296 unreviewed entries match.

Condition Set 3

4 condition(s)
Notes:

UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.

Condition Set 4

3 condition(s)
Notes:

UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0048468 or a descendant, 8 of those by a manual-evidence GO annotation. 848 unreviewed entries match.

Condition Set 5

3 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0048468 or a descendant, 8 of those by a manual-evidence GO annotation. 3940 unreviewed entries match.

Condition Set 6

3 condition(s)
Notes:

UniProtKB release 2026_04: 11 reviewed entries match this set; 10 of them carry GO:0048468 or a descendant, 7 of those by a manual-evidence GO annotation. 1304 unreviewed entries match.

Condition Set 7

3 condition(s)
Notes:

UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0048468 or a descendant, 6 of those by a manual-evidence GO annotation. 5382 unreviewed entries match.

Condition Set 8

4 condition(s)
Notes:

UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.

Condition Set 9

4 condition(s)
Notes:

UniProtKB release 2026_04: 29 reviewed entries match this set; 29 of them carry GO:0048468 or a descendant, 6 of those by a manual-evidence GO annotation. 902 unreviewed entries match.

Condition Set 10

4 condition(s)
Notes:

UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.

Assessments

Raw YAML

View Source YAML 
id: ARBA00028665
description: >-
  Assigns GO:0048468 (cell development) through 392 alternative condition sets. Every set is a conjunction
  of one to three InterPro entries, PANTHER families or CATH FunFams with a taxon.
status: IN_PROGRESS
rule_type: ARBA
rule:
  rule_id: ARBA00028665
  condition_sets:
  - number: 1
    conditions:
    - condition_type: INTERPRO
      value: IPR000210
      curie: InterPro:IPR000210
      label: BTB/POZ domain
      negated: false
    - condition_type: INTERPRO
      value: IPR013087
      curie: InterPro:IPR013087
      label: Zinc finger C2H2-type
      negated: false
    - condition_type: INTERPRO
      value: IPR051095
      curie: InterPro:IPR051095
      label: Drosophila Developmental Transcription Regulators
      negated: false
    - condition_type: TAXON
      value: Archaea
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: >-
      UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or
      a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No
      UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.
  - number: 2
    conditions:
    - condition_type: INTERPRO
      value: IPR000210
      curie: InterPro:IPR000210
      label: BTB/POZ domain
      negated: false
    - condition_type: INTERPRO
      value: IPR013087
      curie: InterPro:IPR013087
      label: Zinc finger C2H2-type
      negated: false
    - condition_type: INTERPRO
      value: IPR051095
      curie: InterPro:IPR051095
      label: Drosophila Developmental Transcription Regulators
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 13 reviewed entries match this set; 13 of them carry GO:0048468 or
      a descendant, 13 of those by a manual-evidence GO annotation. 6296 unreviewed entries match.
  - number: 3
    conditions:
    - condition_type: INTERPRO
      value: IPR000210
      curie: InterPro:IPR000210
      label: BTB/POZ domain
      negated: false
    - condition_type: INTERPRO
      value: IPR013087
      curie: InterPro:IPR013087
      label: Zinc finger C2H2-type
      negated: false
    - condition_type: INTERPRO
      value: IPR051095
      curie: InterPro:IPR051095
      label: Drosophila Developmental Transcription Regulators
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or
      a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No
      UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.
  - number: 4
    conditions:
    - condition_type: INTERPRO
      value: IPR000819
      curie: InterPro:IPR000819
      label: Peptidase M17, leucyl aminopeptidase, C-terminal
      negated: false
    - condition_type: INTERPRO
      value: IPR008283
      curie: InterPro:IPR008283
      label: Peptidase M17, leucyl aminopeptidase, N-terminal
      negated: false
    - condition_type: TAXON
      value: Ecdysozoa
      curie: NCBITaxon:1206794
      label: Ecdysozoa
      negated: false
    notes: >-
      UniProtKB release 2026_04: 8 reviewed entries match this set; 8 of them carry GO:0048468 or
      a descendant, 8 of those by a manual-evidence GO annotation. 848 unreviewed entries match.
  - number: 5
    conditions:
    - condition_type: INTERPRO
      value: IPR000980
      curie: InterPro:IPR000980
      label: SH2 domain
      negated: false
    - condition_type: INTERPRO
      value: IPR001452
      curie: InterPro:IPR001452
      label: SH3 domain
      negated: false
    - condition_type: TAXON
      value: Arthropoda
      curie: NCBITaxon:6656
      label: Arthropoda
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0048468 or
      a descendant, 8 of those by a manual-evidence GO annotation. 3940 unreviewed entries match.
  - number: 6
    conditions:
    - condition_type: INTERPRO
      value: IPR003586
      curie: InterPro:IPR003586
      label: Hint domain C-terminal
      negated: false
    - condition_type: INTERPRO
      value: IPR006141
      curie: InterPro:IPR006141
      label: Intein N-terminal splicing region
      negated: false
    - condition_type: TAXON
      value: Chordata
      curie: NCBITaxon:7711
      label: Chordata
      negated: false
    notes: >-
      UniProtKB release 2026_04: 11 reviewed entries match this set; 10 of them carry GO:0048468 or
      a descendant, 7 of those by a manual-evidence GO annotation. 1304 unreviewed entries match.
  - number: 7
    conditions:
    - condition_type: INTERPRO
      value: IPR000242
      curie: InterPro:IPR000242
      label: Tyrosine-specific protein phosphatase, PTPase domain
      negated: false
    - condition_type: INTERPRO
      value: IPR000387
      curie: InterPro:IPR000387
      label: Tyrosine-specific protein phosphatases domain
      negated: false
    - condition_type: TAXON
      value: Hexapoda
      curie: NCBITaxon:6960
      label: Hexapoda
      negated: false
    notes: >-
      UniProtKB release 2026_04: 9 reviewed entries match this set; 9 of them carry GO:0048468 or
      a descendant, 6 of those by a manual-evidence GO annotation. 5382 unreviewed entries match.
  - number: 8
    conditions:
    - condition_type: INTERPRO
      value: IPR000320
      curie: InterPro:IPR000320
      label: Hedgehog, N-terminal signalling domain
      negated: false
    - condition_type: INTERPRO
      value: IPR001657
      curie: InterPro:IPR001657
      label: Hedgehog protein
      negated: false
    - condition_type: PANTHER
      value: PTHR11889:SF36
      curie: PANTHER:PTHR11889:SF36
      label: SONIC HEDGEHOG PROTEIN
      negated: false
    - condition_type: TAXON
      value: Archaea
      curie: NCBITaxon:2157
      label: Archaea
      negated: false
    notes: >-
      UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or
      a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No
      UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.
  - number: 9
    conditions:
    - condition_type: INTERPRO
      value: IPR000320
      curie: InterPro:IPR000320
      label: Hedgehog, N-terminal signalling domain
      negated: false
    - condition_type: INTERPRO
      value: IPR001657
      curie: InterPro:IPR001657
      label: Hedgehog protein
      negated: false
    - condition_type: PANTHER
      value: PTHR11889:SF36
      curie: PANTHER:PTHR11889:SF36
      label: SONIC HEDGEHOG PROTEIN
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      UniProtKB release 2026_04: 29 reviewed entries match this set; 29 of them carry GO:0048468 or
      a descendant, 6 of those by a manual-evidence GO annotation. 902 unreviewed entries match.
  - number: 10
    conditions:
    - condition_type: INTERPRO
      value: IPR000320
      curie: InterPro:IPR000320
      label: Hedgehog, N-terminal signalling domain
      negated: false
    - condition_type: INTERPRO
      value: IPR001657
      curie: InterPro:IPR001657
      label: Hedgehog protein
      negated: false
    - condition_type: PANTHER
      value: PTHR11889:SF36
      curie: PANTHER:PTHR11889:SF36
      label: SONIC HEDGEHOG PROTEIN
      negated: false
    - condition_type: TAXON
      value: Bacteria
      curie: NCBITaxon:2
      label: Bacteria
      negated: false
    notes: >-
      UniProtKB release 2026_04: 0 reviewed entries match this set; 0 of them carry GO:0048468 or
      a descendant, 0 of those by a manual-evidence GO annotation. 0 unreviewed entries match. No
      UniProtKB entry matches; the same conditions are repeated in a neighbouring set for Eukaryota.
  go_annotations:
  - go_id: GO:0048468
    go_label: cell development
    aspect: BP
  entries: []
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2021-10-20'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 392
review_summary: >-
  The first 10 of the 392 live condition sets were examined. Six match reviewed entries, and 78 of
  79 of those entries carry GO:0048468 or a descendant, 48 by manual evidence. Four of the ten repeat
  the conditions of a neighbouring set for Archaea or Bacteria and match no UniProtKB entry. The other
  382 sets were not examined.
action: UNDECIDED
action_rationale: >-
  The rule was sampled, not examined set by set, so no verdict is given. The sampled sets are sound,
  which removes the grounds of the earlier verdict but does not establish that every set is right.
  The counts are from Swiss-Prot, which is also what ARBA learns its rules from, so they show the
  condition sets are coherent rather than giving an independent error rate for unreviewed entries.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0048468
  label: cell development
  assessment: UNDECIDED
  correct_examples:
  - Q9VQ30
  - Q8IN81
  - Q24174
  notes: >-
    UniProtKB release 2026_04: set 2 reviewed matches with a manual-evidence annotation to GO:0048468
    or a descendant include Q9VQ30 (Drosophila chinmo), Q8IN81 (fru) and Q24174 (ab). Per-set counts
    are in the condition set notes.
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    Manual inspection shows the condition sets overlap and are heterogeneous, and the rule would over-annotate
    housekeeping proteins.
  correction: >-
    The file recorded no condition sets and no protein counts, so nothing had been inspected. No over-annotated
    protein was named.
  error_type: UNEXAMINED_RULE
  evidence:
  - The old file recorded condition_sets as an empty list and both protein counts as 0.
- date: '2026-11-10'
  withdrawn_claim: >-
    The rule should be deprecated because it has 174 condition sets, more than the analysis tool can
    process.
  correction: >-
    The number of sets, and the capacity of a tool, are not evidence about whether the annotations
    are right.
  error_type: SIZE_AS_EVIDENCE
  evidence:
  - 'UniProt ARBA API, ARBA00028665, retrieved 2026-11-09: 392 condition sets.'
- date: '2026-11-10'
  withdrawn_claim: >-
    Cell development is too broad for the diverse molecular functions captured, and should be replaced
    by terms such as DNA-binding transcription factor activity.
  correction: >-
    Cell development is a biological process term. Proteins with different molecular functions can
    take part in the same process, and a molecular function term does not replace a process term.
    A general true term is not a reason to deprecate.
  error_type: GENERAL_IS_NOT_WRONG
  evidence:
  - 'QuickGO: GO:0048468 aspect biological_process; GO:0003700 aspect molecular_function.'
- date: '2026-11-10'
  withdrawn_claim: The taxonomic scope is too broad and the restrictions are arbitrary.
  correction: >-
    All 392 live condition sets carry a taxon condition, many of them narrow clades such as Glires,
    Mus or Hexapoda. Narrow restrictions limit reach; they do not widen it.
  error_type: TAXON_MISREAD
  evidence:
  - 'UniProt ARBA API, ARBA00028665: 392 of 392 condition sets contain a taxon condition.'
- date: '2026-11-10'
  withdrawn_claim: The literature gives weak support.
  correction: The only source was the review's own research note.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    The old literature_support block cited only rules/arba/ARBA00028665/ARBA00028665-deep-research-manual.md.