ARBA00085883 proteoglycan catabolic process (GO:0030167)

id: ARBA00085883
description: 'Assigns GO:0030167 proteoglycan catabolic process through four alternative condition sets
  of CATH FunFams: beta-galactosidase (Euarchontoglires), alpha-L-iduronidase (no taxon condition), beta-hexosaminidase
  (Mus) and N-acetylglucosamine-6-sulfatase (Eukaryota).'
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00085883
  condition_sets:
  - number: 1
    conditions:
    - condition_type: FUNFAM
      value: 2.60.120.260:FF:000115
      curie: CATH.FUNFAM:2.60.120.260:FF:000115
      label: Beta-galactosidase
      negated: false
    - condition_type: FUNFAM
      value: 3.20.20.80:FF:000017
      curie: CATH.FUNFAM:3.20.20.80:FF:000017
      label: Beta-galactosidase
      negated: false
    - condition_type: TAXON
      value: '314146'
      curie: NCBITaxon:314146
      label: Euarchontoglires
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 92 TrEMBL entries match. QuickGO, GO:0030167
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 2 with IEA only, 0 with none. Examples: P16278 (BGAL_HUMAN) GO:0042340 keratan sulfate proteoglycan
      catabolic process, IMP, PMID:31720227; P23780 (BGAL_MOUSE) GO:0042340 keratan sulfate proteoglycan
      catabolic process, IMP, PMID:31720227.'
    pairwise_overlap:
    - condition_a: 2.60.120.260:FF:000115
      condition_b: 3.20.20.80:FF:000017
      protein_database: SWISSPROT
      count_a: 7
      count_b: 10
      intersection_count: 7
      a_minus_b_count: 0
      b_minus_a_count: 3
      jaccard_similarity: 0.7
      containment_a_in_b: 1.0
      containment_b_in_a: 0.7
      interpretation: SUBSET
  - number: 2
    conditions:
    - condition_type: FUNFAM
      value: 2.60.40.10:FF:001526
      curie: CATH.FUNFAM:2.60.40.10:FF:001526
      label: Alpha-L-iduronidase
      negated: false
    - condition_type: FUNFAM
      value: 2.60.40.1500:FF:000001
      curie: CATH.FUNFAM:2.60.40.1500:FF:000001
      label: Alpha-L-iduronidase
      negated: false
    - condition_type: FUNFAM
      value: 3.20.20.80:FF:000059
      curie: CATH.FUNFAM:3.20.20.80:FF:000059
      label: Alpha-L-iduronidase
      negated: false
    notes: 'UniProtKB query, November 2026: 3 Swiss-Prot and 99 TrEMBL entries match. QuickGO, GO:0030167
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P35475 (IDUA_HUMAN) GO:0030209 dermatan sulfate proteoglycan
      catabolic process, IDA, PMID:24036510; P48441 (IDUA_MOUSE) GO:0030200 heparan sulfate proteoglycan
      catabolic process, IMP, PMID:15979918.'
    pairwise_overlap:
    - condition_a: 2.60.40.10:FF:001526
      condition_b: 2.60.40.1500:FF:000001
      protein_database: SWISSPROT
      count_a: 3
      count_b: 3
      intersection_count: 3
      a_minus_b_count: 0
      b_minus_a_count: 0
      jaccard_similarity: 1.0
      containment_a_in_b: 1.0
      containment_b_in_a: 1.0
      interpretation: REDUNDANT
    - condition_a: 2.60.40.10:FF:001526
      condition_b: 3.20.20.80:FF:000059
      protein_database: SWISSPROT
      count_a: 3
      count_b: 3
      intersection_count: 3
      a_minus_b_count: 0
      b_minus_a_count: 0
      jaccard_similarity: 1.0
      containment_a_in_b: 1.0
      containment_b_in_a: 1.0
      interpretation: REDUNDANT
    - condition_a: 2.60.40.1500:FF:000001
      condition_b: 3.20.20.80:FF:000059
      protein_database: SWISSPROT
      count_a: 3
      count_b: 3
      intersection_count: 3
      a_minus_b_count: 0
      b_minus_a_count: 0
      jaccard_similarity: 1.0
      containment_a_in_b: 1.0
      containment_b_in_a: 1.0
      interpretation: REDUNDANT
  - number: 3
    conditions:
    - condition_type: FUNFAM
      value: 3.20.20.80:FF:000049
      curie: CATH.FUNFAM:3.20.20.80:FF:000049
      label: Beta-hexosaminidase A
      negated: false
    - condition_type: FUNFAM
      value: 3.30.379.10:FF:000001
      curie: CATH.FUNFAM:3.30.379.10:FF:000001
      label: Beta-hexosaminidase subunit beta
      negated: false
    - condition_type: TAXON
      value: '10088'
      curie: NCBITaxon:10088
      label: Mus
      negated: false
    notes: 'UniProtKB query, November 2026: 2 Swiss-Prot and 13 TrEMBL entries match. QuickGO, GO:0030167
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 0 with other manual evidence
      only, 0 with IEA only, 0 with none. Examples: P20060 (HEXB_MOUSE) GO:0030207 chondroitin sulfate
      proteoglycan catabolic process, IMP, PMID:22451654; P29416 (HEXA_MOUSE) GO:0030209 dermatan sulfate
      proteoglycan catabolic process, IGI, PMID:11707436.'
    pairwise_overlap:
    - condition_a: 3.20.20.80:FF:000049
      condition_b: 3.30.379.10:FF:000001
      protein_database: SWISSPROT
      count_a: 9
      count_b: 7
      intersection_count: 7
      a_minus_b_count: 2
      b_minus_a_count: 0
      jaccard_similarity: 0.7777777777777778
      containment_a_in_b: 0.7777777777777778
      containment_b_in_a: 1.0
      interpretation: SUBSET
  - number: 4
    conditions:
    - condition_type: FUNFAM
      value: 3.40.720.10:FF:000012
      curie: CATH.FUNFAM:3.40.720.10:FF:000012
      label: N-acetylglucosamine-6-sulfatase
      negated: false
    - condition_type: TAXON
      value: '2759'
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: 'UniProtKB query, November 2026: 4 Swiss-Prot and 657 TrEMBL entries match. QuickGO, GO:0030167
      or a descendant on the Swiss-Prot entries: 2 with experimental evidence, 1 with other manual evidence
      only, 1 with IEA only, 0 with none. Examples: P15586 (GNS_HUMAN) GO:0030200 heparan sulfate proteoglycan
      catabolic process, IDA, PMID:15595925; Q8BFR4 (GNS_MOUSE) GO:0030200 heparan sulfate proteoglycan
      catabolic process, IMP, PMID:33320673.'
  go_annotations:
  - go_id: GO:0030167
    go_label: proteoglycan catabolic process
    aspect: BP
  entries:
  - id: 2.60.120.260:FF:000115
    type: FUNFAM
    label: Beta-galactosidase
    appears_in_condition_sets:
    - 1
    protein_count: 7
    related_entries:
    - relationship: PREDICTS
      target_id: 3.20.20.80:FF:000017
      containment: 1.0
      jaccard_similarity: 0.7
      intersection_count: 7
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000049
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 3.30.379.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 0.429
      jaccard_similarity: 0.051
      intersection_count: 3
      exclusive_count: 4
  - id: 2.60.40.10:FF:001526
    type: FUNFAM
    label: Alpha-L-iduronidase
    appears_in_condition_sets:
    - 2
    protein_count: 3
    related_entries:
    - relationship: EQUIV
      target_id: 2.60.120.260:FF:000115
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000017
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 3
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 3
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000049
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.30.379.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 1.0
      jaccard_similarity: 0.055
      intersection_count: 3
      exclusive_count: 0
  - id: 2.60.40.1500:FF:000001
    type: FUNFAM
    label: Alpha-L-iduronidase
    appears_in_condition_sets:
    - 2
    protein_count: 3
    related_entries:
    - relationship: EQUIV
      target_id: 2.60.120.260:FF:000115
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000017
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 3
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 3
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000049
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.30.379.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 1.0
      jaccard_similarity: 0.055
      intersection_count: 3
      exclusive_count: 0
  - id: 3.20.20.80:FF:000017
    type: FUNFAM
    label: Beta-galactosidase
    appears_in_condition_sets:
    - 1
    protein_count: 10
    related_entries:
    - relationship: PREDICTED_BY
      target_id: 2.60.120.260:FF:000115
      containment: 0.7
      jaccard_similarity: 0.7
      intersection_count: 7
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000049
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 3.30.379.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 0.3
      jaccard_similarity: 0.048
      intersection_count: 3
      exclusive_count: 7
  - id: 3.20.20.80:FF:000049
    type: FUNFAM
    label: Beta-hexosaminidase A
    appears_in_condition_sets:
    - 3
    protein_count: 9
    related_entries:
    - relationship: EQUIV
      target_id: 2.60.120.260:FF:000115
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000017
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: PREDICTED_BY
      target_id: 3.30.379.10:FF:000001
      containment: 1.0
      jaccard_similarity: 0.778
      intersection_count: 7
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 0.778
      jaccard_similarity: 0.123
      intersection_count: 7
      exclusive_count: 2
  - id: 3.20.20.80:FF:000059
    type: FUNFAM
    label: Alpha-L-iduronidase
    appears_in_condition_sets:
    - 2
    protein_count: 3
    related_entries:
    - relationship: EQUIV
      target_id: 2.60.120.260:FF:000115
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000017
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 3
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 3
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000049
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.30.379.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 3
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 1.0
      jaccard_similarity: 0.055
      intersection_count: 3
      exclusive_count: 0
  - id: 3.30.379.10:FF:000001
    type: FUNFAM
    label: Beta-hexosaminidase subunit beta
    appears_in_condition_sets:
    - 3
    protein_count: 7
    related_entries:
    - relationship: EQUIV
      target_id: 2.60.120.260:FF:000115
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000017
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: PREDICTS
      target_id: 3.20.20.80:FF:000049
      containment: 0.778
      jaccard_similarity: 0.778
      intersection_count: 7
      exclusive_count: 2
    - relationship: EQUIV
      target_id: 3.40.720.10:FF:000012
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 0.857
      jaccard_similarity: 0.107
      intersection_count: 6
      exclusive_count: 1
  - id: 3.40.720.10:FF:000012
    type: FUNFAM
    label: N-acetylglucosamine-6-sulfatase
    appears_in_condition_sets:
    - 4
    protein_count: 4
    related_entries:
    - relationship: EQUIV
      target_id: 2.60.120.260:FF:000115
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000017
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: EQUIV
      target_id: 2.60.40.10:FF:001526
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: EQUIV
      target_id: 2.60.40.1500:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000059
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: EQUIV
      target_id: 3.20.20.80:FF:000049
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: EQUIV
      target_id: 3.30.379.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 4
    - relationship: PREDICTS
      target_id: GO:0030167
      containment: 0.5
      jaccard_similarity: 0.035
      intersection_count: 2
      exclusive_count: 2
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2025-03-21'
  modified_date: '2026-07-18'
  retrieved_date: '2026-11-09'
  source_condition_set_count: 4
review_summary: 'All four live condition sets were examined. The Swiss-Prot matches of every set carry
  a descendant of GO:0030167 with experimental evidence: beta-galactosidase GLB1 (keratan sulfate proteoglycan
  catabolic process, IMP), alpha-L-iduronidase (dermatan sulfate and heparan sulfate proteoglycan catabolic
  process, IDA and IMP), mouse HEXA and HEXB (dermatan sulfate proteoglycan catabolic process, IGI) and
  N-acetylglucosamine-6-sulfatase (heparan sulfate proteoglycan catabolic process, IDA and IMP). Beta-galactosidase
  and beta-hexosaminidase also degrade gangliosides; that is a further function, not a reason to withhold
  this one.'
action: ACCEPT
action_rationale: Each set selects one lysosomal enzyme family whose reviewed members are experimentally
  annotated to a child of the rule's term. The taxon conditions on sets 1 and 3 are narrow, which limits
  coverage but does not make the annotation wrong.
literature_support:
  assessment: STRONG
  notes: 'Curated GO annotations (QuickGO, November 2026): P16278 (GLB1) GO:0042340 IMP PMID:31720227;
    P35475 (IDUA) GO:0030209 IDA PMID:24036510; HEXA_MOUSE and HEXB_MOUSE GO:0030209 IGI PMID:11707436;
    P15586 (GNS) GO:0030200 IDA PMID:15595925. GO:0042340, GO:0030209 and GO:0030200 are descendants of
    GO:0030167.'
go_specificity:
  assessment: APPROPRIATE
  notes: GO:0030167 is the common parent of the three child terms the matched proteins are experimentally
    annotated to (GO:0042340 keratan sulfate, GO:0030209 dermatan sulfate and GO:0030200 heparan sulfate
    proteoglycan catabolic process). A per-set child term would be more specific.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0030167
  label: proteoglycan catabolic process
  assessment: CORRECT
  correct_examples:
  - P16278
  - P23780
  - P35475
  - P48441
  - P20060
  - P29416
  - P15586
  - Q8BFR4
  notes: Per-set receipts are in rule.condition_sets[].notes. Accessions listed are Swiss-Prot matches
    with experimental evidence for a descendant of GO:0030167 in QuickGO.
confidence: 0.8
corrections:
- date: '2026-11-10'
  withdrawn_claim: Condition sets 1 (beta-galactosidase) and 3 (beta-hexosaminidase) should be removed
    because the primary role of these enzymes is ganglioside catabolism.
  correction: Both families are experimentally annotated to proteoglycan catabolism. A protein can take
    part in two processes; the second does not make the first wrong.
  error_type: REFUTED_BY_CURATED_ANNOTATION
  evidence:
  - P16278 (BGAL_HUMAN) GO:0042340 keratan sulfate proteoglycan catabolic process, IMP, PMID:31720227
  - HEXB_MOUSE GO:0030209 dermatan sulfate proteoglycan catabolic process, IGI, PMID:11707436; HEXA_MOUSE
    GO:0030209 IGI PMID:11707436
  - GO:0042340 and GO:0030209 are descendants of GO:0030167 (QuickGO)
- date: '2026-11-10'
  withdrawn_claim: GO:0030167 is too broad for sets 1 and 3 because it does not capture ganglioside metabolism.
  correction: Ganglioside catabolism is in a different branch of GO and is not a more specific form of
    proteoglycan catabolism, so this is not a specificity problem.
  error_type: ONTOLOGY_MISREAD
  evidence:
  - 'GO:0006689 ganglioside catabolic process: ancestors do not include GO:0030167 (QuickGO)'
- date: '2026-11-10'
  withdrawn_claim: GO:1902556 is dermatan sulfate catabolic process; GO:0006689 is GM1 ganglioside catabolic
    process; GO:0006687 is ganglioside catabolic process.
  correction: GO:1902556 is phosphatidylinositol transporter complex; GO:0006689 is ganglioside catabolic
    process; GO:0006687 is glycosphingolipid metabolic process. The dermatan sulfate term is GO:0030209.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - QuickGO term names for GO:1902556, GO:0006689, GO:0006687, GO:0030209
- date: '2026-11-10'
  withdrawn_claim: Condition set 3 is restricted to taxon 862507 (Mus), "mouse and rat genera"; sets 1
    and 4 use Eukaryota and Metazoa.
  correction: The live rule restricts set 3 to genus Mus (NCBITaxon:10088), set 1 to Euarchontoglires
    and set 4 to Eukaryota. Rats are genus Rattus.
  error_type: STALE_RULE_VERSION
  evidence:
  - rest.uniprot.org/arba/ARBA00085883 retrieved 2026-11-09, modifiedDate 2026-07-18
  - 'UniProt taxonomy 862507: Mus, rank subgenus'
- date: '2026-11-10'
  withdrawn_claim: Quotations from web pages were given as support, for example "Beta-galactosidase is
    a conserved lysosomal enzyme found across eukaryotes, supporting the Eukaryota scope in condition
    set 1".
  correction: These strings contain the reviewer's own conclusions and are not quotations from the cited
    pages. They and the web references were removed.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - The phrase "condition set 1" cannot occur in a MedlinePlus gene page