ARBA00088058 microtubule plus-end binding (GO:0051010)

id: ARBA00088058
description: >-
  Assigns GO:0051010 (microtubule plus-end binding) through five condition sets: CLIP1/CLIP2 CAP-Gly FunFams
  in Glires, EB1 (MAPRE1) FunFams in Eukaryota, CLASP1/CLASP2 FunFams in Primates, the fungal EB FunFam
  (BIM1, mal3) and the CKAP5 FunFam in Dikarya (alp14, dis1).
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00088058
  condition_sets:
  - number: 1
    conditions:
    - condition_type: FUNFAM
      value: 2.30.30.190:FF:000001
      curie: CATH.FunFam:2.30.30.190:FF:000001
      label: Putative CAP-Gly domain-containing linker protein 1
      negated: false
    - condition_type: FUNFAM
      value: 2.30.30.190:FF:000002
      curie: CATH.FunFam:2.30.30.190:FF:000002
      label: CAP-Gly domain containing linker protein 1
      negated: false
    - condition_type: TAXON
      value: Glires
      curie: NCBITaxon:314147
      label: Glires
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 4 (UniProtKB query, 2026-11-10); unreviewed entries:
      215. Swiss-Prot matches: O55156 (Clip2), Q922J3 (Clip1), Q9Z0H8 (Clip2), Q9JK25 (Clip1). Experimental
      annotation to GO:0051010 microtubule plus-end binding or an is_a/part_of descendant (QuickGO): O55156
      Clip2 GO:0051010 microtubule plus-end binding IDA PMID:11290329 (UniProt); Q922J3 Clip1 GO:0051010
      microtubule plus-end binding IDA PMID:16148041 (MGI); Q9JK25 Clip1 GO:0051010 microtubule plus-end
      binding IDA PMID:11290329 (UniProt); Q9Z0H8 Clip2 GO:0051010 microtubule plus-end binding IDA PMID:16148041
      (MGI).
    pairwise_overlap:
    - condition_a: 2.30.30.190:FF:000001
      condition_b: 2.30.30.190:FF:000002
      protein_database: SWISSPROT
      count_a: 7
      count_b: 7
      intersection_count: 7
      a_minus_b_count: 0
      b_minus_a_count: 0
      jaccard_similarity: 1.0
      containment_a_in_b: 1.0
      containment_b_in_a: 1.0
      interpretation: REDUNDANT
  - number: 2
    conditions:
    - condition_type: FUNFAM
      value: 1.10.418.10:FF:000007
      curie: CATH.FunFam:1.10.418.10:FF:000007
      label: Microtubule-associated protein, RP/EB family, member 2
      negated: false
    - condition_type: FUNFAM
      value: 1.20.5.1430:FF:000001
      curie: CATH.FunFam:1.20.5.1430:FF:000001
      label: microtubule-associated protein RP/EB family member 1
      negated: false
    - condition_type: TAXON
      value: Eukaryota
      curie: NCBITaxon:2759
      label: Eukaryota
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 9 (UniProtKB query, 2026-11-10); unreviewed entries:
      1514. Swiss-Prot matches: Q15691 (MAPRE1), Q66HR2 (Mapre1), Q61166 (Mapre1), Q3ZBD9 (MAPRE1), Q5R7Z5
      (MAPRE1), Q5ZLC7 (MAPRE1), Q6P848 (mapre1), Q6V291 (MAPRE1), and 1 more. Experimental annotation
      to GO:0051010 microtubule plus-end binding or an is_a/part_of descendant (QuickGO): Q15691 MAPRE1
      GO:0051010 microtubule plus-end binding IDA PMID:15631994 (UniProt); Q61166 Mapre1 GO:0051010 microtubule
      plus-end binding IDA PMID:16148041 (MGI); Q66HR2 Mapre1 GO:0051010 microtubule plus-end binding
      IDA PMID:11290329 (UniProt).
    pairwise_overlap:
    - condition_a: 1.10.418.10:FF:000007
      condition_b: 1.20.5.1430:FF:000001
      protein_database: SWISSPROT
      count_a: 19
      count_b: 9
      intersection_count: 9
      a_minus_b_count: 10
      b_minus_a_count: 0
      jaccard_similarity: 0.47368421052631576
      containment_a_in_b: 0.47368421052631576
      containment_b_in_a: 1.0
      interpretation: SUBSET
  - number: 3
    conditions:
    - condition_type: FUNFAM
      value: 1.25.10.10:FF:000001
      curie: CATH.FunFam:1.25.10.10:FF:000001
      label: CLIP-associating protein 1 isoform 2
      negated: false
    - condition_type: FUNFAM
      value: 1.25.10.10:FF:000005
      curie: CATH.FunFam:1.25.10.10:FF:000005
      label: CLIP-associating protein 1 isoform 2
      negated: false
    - condition_type: TAXON
      value: Primates
      curie: NCBITaxon:9443
      label: Primates
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2 (UniProtKB query, 2026-11-10); unreviewed entries:
      455. Swiss-Prot matches: Q7Z460 (CLASP1), O75122 (CLASP2). Experimental annotation to GO:0051010
      microtubule plus-end binding or an is_a/part_of descendant (QuickGO): O75122 CLASP2 GO:0051010 microtubule
      plus-end binding IDA PMID:11290329 (UniProt); Q7Z460 CLASP1 GO:0051010 microtubule plus-end binding
      IDA PMID:12837247 (UniProt).
    pairwise_overlap:
    - condition_a: 1.25.10.10:FF:000001
      condition_b: 1.25.10.10:FF:000005
      protein_database: SWISSPROT
      count_a: 9
      count_b: 9
      intersection_count: 9
      a_minus_b_count: 0
      b_minus_a_count: 0
      jaccard_similarity: 1.0
      containment_a_in_b: 1.0
      containment_b_in_a: 1.0
      interpretation: REDUNDANT
  - number: 4
    conditions:
    - condition_type: FUNFAM
      value: 1.10.418.10:FF:000028
      curie: CATH.FunFam:1.10.418.10:FF:000028
      label: RP/EB family microtubule-associated protein
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2 (UniProtKB query, 2026-11-10); unreviewed entries:
      1415. Swiss-Prot matches: P40013 (BIM1), Q10113 (mal3). Experimental annotation to GO:0051010 microtubule
      plus-end binding or an is_a/part_of descendant (QuickGO): P40013 BIM1 GO:0051010 microtubule plus-end
      binding IDA PMID:20392838 (SGD); Q10113 mal3 GO:0051010 microtubule plus-end binding EXP PMID:23128140
      (PomBase).
  - number: 5
    conditions:
    - condition_type: FUNFAM
      value: 1.25.10.10:FF:000019
      curie: CATH.FunFam:1.25.10.10:FF:000019
      label: Cytoskeleton-associated protein 5
      negated: false
    - condition_type: TAXON
      value: Dikarya
      curie: NCBITaxon:451864
      label: Dikarya
      negated: false
    notes: >-
      Swiss-Prot entries matching the whole conjunction: 2 (UniProtKB query, 2026-11-10); unreviewed entries:
      1316. Swiss-Prot matches: O94534 (alp14), Q09933 (dis1). Experimental annotation to GO:0051010 microtubule
      plus-end binding or an is_a/part_of descendant (QuickGO): Q09933 dis1 GO:0051010 microtubule plus-end
      binding EXP PMID:36435910 (PomBase).
  go_annotations:
  - go_id: GO:0051010
    go_label: microtubule plus-end binding
    aspect: MF
  entries:
  - id: 1.10.418.10:FF:000007
    type: FUNFAM
    label: Microtubule-associated protein, RP/EB family, member 2
    appears_in_condition_sets:
    - 2
    protein_count: 19
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 19
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 19
    - relationship: PREDICTED_BY
      target_id: 1.20.5.1430:FF:000001
      containment: 1.0
      jaccard_similarity: 0.474
      intersection_count: 9
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 19
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 19
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 19
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 19
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 1.0
      jaccard_similarity: 0.133
      intersection_count: 19
      exclusive_count: 0
  - id: 1.10.418.10:FF:000028
    type: FUNFAM
    label: RP/EB family microtubule-associated protein
    appears_in_condition_sets:
    - 4
    protein_count: 7
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000007
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.20.5.1430:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 0.571
      jaccard_similarity: 0.027
      intersection_count: 4
      exclusive_count: 3
  - id: 1.20.5.1430:FF:000001
    type: FUNFAM
    label: microtubule-associated protein RP/EB family member 1
    appears_in_condition_sets:
    - 2
    protein_count: 9
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: PREDICTS
      target_id: 1.10.418.10:FF:000007
      containment: 0.474
      jaccard_similarity: 0.474
      intersection_count: 9
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 1.0
      jaccard_similarity: 0.063
      intersection_count: 9
      exclusive_count: 0
  - id: 1.25.10.10:FF:000001
    type: FUNFAM
    label: CLIP-associating protein 1 isoform 2
    appears_in_condition_sets:
    - 3
    protein_count: 9
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000007
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.20.5.1430:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 9
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 0.556
      jaccard_similarity: 0.034
      intersection_count: 5
      exclusive_count: 4
  - id: 1.25.10.10:FF:000005
    type: FUNFAM
    label: CLIP-associating protein 1 isoform 2
    appears_in_condition_sets:
    - 3
    protein_count: 9
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000007
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.20.5.1430:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 9
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 9
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 0.556
      jaccard_similarity: 0.034
      intersection_count: 5
      exclusive_count: 4
  - id: 1.25.10.10:FF:000019
    type: FUNFAM
    label: Cytoskeleton-associated protein 5
    appears_in_condition_sets:
    - 5
    protein_count: 10
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000007
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 1.20.5.1430:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 10
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 1.0
      jaccard_similarity: 0.07
      intersection_count: 10
      exclusive_count: 0
  - id: 2.30.30.190:FF:000001
    type: FUNFAM
    label: Putative CAP-Gly domain-containing linker protein 1
    appears_in_condition_sets:
    - 1
    protein_count: 7
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000002
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 7
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000007
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.20.5.1430:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 1.0
      jaccard_similarity: 0.049
      intersection_count: 7
      exclusive_count: 0
  - id: 2.30.30.190:FF:000002
    type: FUNFAM
    label: CAP-Gly domain containing linker protein 1
    appears_in_condition_sets:
    - 1
    protein_count: 7
    related_entries:
    - relationship: EQUIV
      target_id: 2.30.30.190:FF:000001
      containment: 1.0
      jaccard_similarity: 1.0
      intersection_count: 7
      exclusive_count: 0
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000007
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.20.5.1430:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000001
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000005
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.10.418.10:FF:000028
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: EQUIV
      target_id: 1.25.10.10:FF:000019
      containment: 0.0
      jaccard_similarity: 0.0
      intersection_count: 0
      exclusive_count: 7
    - relationship: PREDICTS
      target_id: GO:0051010
      containment: 1.0
      jaccard_similarity: 0.049
      intersection_count: 7
      exclusive_count: 0
  reviewed_protein_count: 0
  unreviewed_protein_count: 0
  created_date: '2025-03-21'
  modified_date: '2025-05-15'
  source_condition_set_count: 5
  retrieved_date: '2026-11-09'
review_summary: >-
  All five live condition sets were examined. Every Swiss-Prot entry that matches a full conjunction is
  curated to GO:0051010 itself, and each set has at least one match with experimental evidence: CLIP1
  and CLIP2 of mouse and rat (set 1), MAPRE1 of human, mouse and rat (set 2), human CLASP1 and CLASP2
  (set 3), S. cerevisiae BIM1 and S. pombe mal3 (set 4), and S. pombe dis1 (set 5; alp14 by TAS).
action: ACCEPT
action_rationale: >-
  Each condition set identifies a known plus-end tracking protein family and its reviewed matches are
  experimentally annotated to the exact term. No change to the condition sets is proposed.
go_specificity:
  assessment: APPROPRIATE
  notes: >-
    The reviewed matches of all five sets are curated to GO:0051010 itself, for example Q922J3 Clip1 IDA
    PMID:16148041, Q15691 MAPRE1 IDA PMID:15631994, Q7Z460 CLASP1 IDA PMID:12837247, P40013 BIM1 IDA PMID:20392838
    and Q09933 dis1 EXP PMID:36435910.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:0051010
  label: microtubule plus-end binding
  assessment: CORRECT
  correct_examples:
  - O55156
  - Q922J3
  - Q15691
  - Q61166
  - O75122
  - Q7Z460
  - P40013
  - Q10113
  - Q09933
  notes: >-
    O55156 Clip2 IDA PMID:11290329; Q922J3 Clip1 IDA PMID:16148041; Q15691 MAPRE1 IDA PMID:15631994; Q61166
    Mapre1 IDA PMID:16148041; O75122 CLASP2 IDA PMID:11290329; Q7Z460 CLASP1 IDA PMID:12837247; P40013
    BIM1 IDA PMID:20392838; Q10113 mal3 EXP PMID:23128140; Q09933 dis1 EXP PMID:36435910; O94534 alp14
    TAS PMID:15464854. All annotations are to GO:0051010.
confidence: 0.85
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    In set 2, FunFam 1.20.5.1430:FF:000001 is contained in 1.10.418.10:FF:000007, adds no coverage and
    should be removed.
  correction: >-
    The conditions of a set are joined by AND. When B is a subset of A, B is the condition that defines
    the set; removing it would widen the set from 9 to 19 Swiss-Prot proteins.
  error_type: CONJUNCTION_IGNORED
  evidence:
  - 'pairwise_overlap of set 2: count_a 19, count_b 9, intersection 9 (Swiss-Prot)'
- date: '2026-11-10'
  withdrawn_claim: Sets 1 and 3 both target CAP-Gly proteins.
  correction: >-
    Set 3 uses CLIP-associating protein FunFams of CATH superfamily 1.25.10.10 and matches CLASP1 and
    CLASP2, not CAP-Gly linker proteins.
  error_type: WRONG_IDENTIFIER_MEANING
  evidence:
  - 'Live set 3 Swiss-Prot matches: Q7Z460 (CLASP1), O75122 (CLASP2)'
  - 'CATH FunFam 1.25.10.10:FF:000001 and :000005 label: CLIP-associating protein 1 isoform 2'
- date: '2026-11-10'
  withdrawn_claim: Set 4 (EB proteins in Fungi) is entirely subsumed by set 2 (EB proteins in Eukaryota).
  correction: The two sets use different FunFams and match different proteins.
  error_type: CONJUNCTION_IGNORED
  evidence:
  - >-
    Live set 2 Swiss-Prot matches are 9 MAPRE1 entries; live set 4 Swiss-Prot matches are P40013 (BIM1)
    and Q10113 (mal3)
- date: '2026-11-10'
  withdrawn_claim: Pairs of FunFams in sets 1 and 3 are 100% redundant and one of each should be removed.
  correction: >-
    The identity was observed on 7 and 9 Swiss-Prot proteins and was not tested on unreviewed entries,
    so removal is not supported.
  error_type: SAMPLE_OVERGENERALISED
  evidence:
  - 'pairwise_overlap of set 1: 7 of 7; of set 3: 9 of 9 (Swiss-Prot)'
- date: '2026-11-10'
  withdrawn_claim: >-
    Literature support and taxonomic scope were supported by AI-generated deep-research reports.
  correction: >-
    Those reports are not literature; the blocks were removed and curated annotations are cited instead.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - >-
    Previous supported_by entries cited only ARBA00088058-deep-research-perplexity.md and ARBA00088058-deep-research-falcon.md