View original ARBA rule on UniProt
Withdrawn ARBA rule. UniProt no longer serves it, and its condition sets were never recorded in this repository. It is reported to have assigned GO:0160103 tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity.
Condition-set counts describe the sets recorded in this review, which may omit the full rule.
No domain overlap table is shown: the cached overlap analysis for this version of the review is not available.
Run just analyze-rule ARBA00088072 and re-render to add it.
rest.uniprot.org/arba/ARBA00088072 returns HTTP 404 ("Resource not found"), so the rule is withdrawn. Its conditions are unknown, and nothing can be said about which proteins it annotated or whether those annotations were right.
UniProt has already withdrawn the rule. No judgement on its content is made.
The rule's conditions are not available, so the proteins it annotated cannot be identified. GO:0160103 and GO:0160104 tRNA (guanine(26)-N2)-dimethyltransferase activity are sibling terms under GO:0016423 tRNA (guanine) methyltransferase activity (QuickGO); neither is a more general form of the other.
id: ARBA00088072
description: Withdrawn ARBA rule. UniProt no longer serves it, and its condition sets were never recorded
in this repository. It is reported to have assigned GO:0160103 tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase
activity.
status: COMPLETE
rule_type: ARBA
rule:
rule_id: ARBA00088072
condition_sets: []
go_annotations:
- go_id: GO:0160103
go_label: tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity
aspect: MF
entries: []
retrieved_date: '2026-11-09'
withdrawn: true
review_summary: rest.uniprot.org/arba/ARBA00088072 returns HTTP 404 ("Resource not found"), so the rule
is withdrawn. Its conditions are unknown, and nothing can be said about which proteins it annotated
or whether those annotations were right.
action: DEPRECATE
action_rationale: UniProt has already withdrawn the rule. No judgement on its content is made.
annotation_assessments:
- annotation_kind: GO_TERM
value: GO:0160103
label: tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity
assessment: UNDECIDED
notes: The rule's conditions are not available, so the proteins it annotated cannot be identified. GO:0160103
and GO:0160104 tRNA (guanine(26)-N2)-dimethyltransferase activity are sibling terms under GO:0016423
tRNA (guanine) methyltransferase activity (QuickGO); neither is a more general form of the other.
confidence: 0.95
corrections:
- date: '2026-11-10'
withdrawn_claim: 'The biological basis for the rule was fundamentally flawed: it applied a dual G26/G27
term to enzymes specific for G26.'
correction: The rule's condition sets were never seen, so which proteins it targeted is unknown. The
evidence discussed concerned a manual SGD annotation of yeast TRM1, not the rule.
error_type: UNEXAMINED_RULE
evidence:
- 'Old review: rule.condition_sets empty, created_date and modified_date "UNKNOWN"'
- 'rest.uniprot.org/arba/ARBA00088072: HTTP 404, 2026-11-09'
- date: '2026-11-10'
withdrawn_claim: GO:0160103 is too broad and GO:0160104 is the more specific appropriate term.
correction: The two terms are siblings describing different reactions; one is not a broader version
of the other.
error_type: ONTOLOGY_MISREAD
evidence:
- 'QuickGO: ancestors of GO:0160104 do not include GO:0160103; both have GO:0016423 among their ancestors'
- date: '2026-11-10'
withdrawn_claim: Quotations attributed to geneontology/go-annotation issue 5782 were given as evidence
on which lineages have G27 activity.
correction: The issue text could not be retrieved and checked, so the quotations and the taxonomic conclusion
drawn from them were removed.
error_type: UNSUPPORTED_SOURCE
evidence:
- Issue not accessible from this review environment (2026-11-09)