ARBA00089395 - ARBA Rule Review

Description

A withdrawn rule. As recorded before withdrawal it had one condition set, CATH FunFam 1.20.1250.20:FF:000011 in Taphrinomycotina, and the earlier analysis of it recorded the consequent as GO:1903710 spermine transmembrane transport.

Analysis Summary

Condition-set counts describe the sets recorded in this review, which may omit the full rule.

0

Domain Pairs Analyzed

1

Recorded condition sets

0

Subset Relationships

0

Redundant Annotations

No domain overlap table is shown: the cached overlap analysis for this version of the review is not available. Run just analyze-rule ARBA00089395 and re-render to add it.

Review Summary

UniProt no longer serves this rule: rest.uniprot.org/arba/ARBA00089395 returned "Resource not found" on 2026-11-09. Its annotation can therefore not be re-examined. For the record, the two recorded conditions match 10 Swiss-Prot entries, all S. pombe major facilitator transporters, and only one of them (Q7Z9I0) carries GO:1903710.

Action Rationale

The rule has been withdrawn by UniProt, so there is nothing left to keep or modify.

Annotation Assessments

UNDECIDED GO_TERM GO:1903710 - spermine transmembrane transport

Matched proteins: ; incorrect:

The consequent is taken from the earlier analysis of this rule and cannot be confirmed now that the rule is withdrawn. Of 10 Swiss-Prot entries matching the recorded conditions, Q7Z9I0 carries GO:1903710 (IEA GO_REF:0000108, from GO:0000297 IBA GO_REF:0000033); O74829 (polyamine transporter shp2) and the other eight do not.

Rule Definition

Condition Sets

Condition Set 1

2 condition(s)

FUNFAM

1.20.1250.20:FF:000011

MFS multidrug transporter, putative

CATH.FunFam:1.20.1250.20:FF:000011
TAXON

Taphrinomycotina

Taphrinomycotina

NCBITaxon:451866

Notes:

Condition set as recorded before the rule was withdrawn; it can no longer be checked against UniProt. Swiss-Prot entries matching these two conditions on 2026-11-09: 10, all from Schizosaccharomyces pombe. One (Q7Z9I0) carries GO:1903710, as IEA GO_REF:0000108 derived from GO:0000297 (IBA); the other nine do not carry it.

Assessments

Raw YAML

View Source YAML

id: ARBA00089395
description: A withdrawn rule. As recorded before withdrawal it had one condition set, CATH FunFam 1.20.1250.20:FF:000011
  in Taphrinomycotina, and the earlier analysis of it recorded the consequent as GO:1903710 spermine transmembrane
  transport.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00089395
  condition_sets:
  - number: 1
    conditions:
    - condition_type: FUNFAM
      value: 1.20.1250.20:FF:000011
      curie: CATH.FunFam:1.20.1250.20:FF:000011
      label: MFS multidrug transporter, putative
      negated: false
    - condition_type: TAXON
      value: Taphrinomycotina
      curie: NCBITaxon:451866
      label: Taphrinomycotina
      negated: false
    notes: 'Condition set as recorded before the rule was withdrawn; it can no longer be checked against UniProt.
      Swiss-Prot entries matching these two conditions on 2026-11-09: 10, all from Schizosaccharomyces pombe. One
      (Q7Z9I0) carries GO:1903710, as IEA GO_REF:0000108 derived from GO:0000297 (IBA); the other nine do not carry
      it.'
  go_annotations: []
  entries: []
  retrieved_date: '2026-11-09'
  withdrawn: true
review_summary: 'UniProt no longer serves this rule: rest.uniprot.org/arba/ARBA00089395 returned "Resource not found"
  on 2026-11-09. Its annotation can therefore not be re-examined. For the record, the two recorded conditions match
  10 Swiss-Prot entries, all S. pombe major facilitator transporters, and only one of them (Q7Z9I0) carries GO:1903710.'
action: DEPRECATE
action_rationale: The rule has been withdrawn by UniProt, so there is nothing left to keep or modify.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:1903710
  label: spermine transmembrane transport
  assessment: UNDECIDED
  notes: The consequent is taken from the earlier analysis of this rule and cannot be confirmed now that the rule
    is withdrawn. Of 10 Swiss-Prot entries matching the recorded conditions, Q7Z9I0 carries GO:1903710 (IEA GO_REF:0000108,
    from GO:0000297 IBA GO_REF:0000033); O74829 (polyamine transporter shp2) and the other eight do not.
confidence: 0.9
corrections:
- date: '2026-11-10'
  withdrawn_claim: Zero protein coverage indicates a problem with the rule conditions.
  correction: The zero counts were unfilled fields (no creation or modification date was recorded either), not a
    measurement. The recorded conditions match 10 Swiss-Prot entries.
  error_type: UNEXAMINED_RULE
  evidence:
  - 'UniProtKB query xref:"funfam-1.20.1250.20:FF:000011" AND taxonomy_id:451866 AND reviewed:true: 10 entries (2026-11-09)'
- date: '2026-11-10'
  withdrawn_claim: The rule should be deprecated because its GO term is novel, that is, not supported by an InterPro2GO
    mapping.
  correction: An annotation not also made by InterPro2GO is not thereby wrong.
  error_type: OTHER
  evidence:
  - 'QuickGO GO:1903710: spermine transmembrane transport, not obsolete'
- date: '2026-11-10'
  withdrawn_claim: The restriction to Taphrinomycotina is unjustifiably narrow and a reason to deprecate.
  correction: A narrow taxon limits coverage; it is not evidence that the annotations made are wrong.
  error_type: LOW_RECALL_IS_NOT_WRONG
  evidence:
  - 'Recorded condition set: FunFam 1.20.1250.20:FF:000011 AND Taphrinomycotina'