ARBA00092121 positive regulation of cellular response to amino acid starvation (GO:1903833)

id: ARBA00092121
description: >-
  ARBA rule that assigned GO:1903833 positive regulation of cellular response to amino acid starvation
  to fungal proteins in CATH FunFam 3.10.20.30:FF:000003 (Developmentally-regulated GTP-binding protein
  1). UniProt no longer serves the rule.
status: COMPLETE
rule_type: ARBA
rule:
  rule_id: ARBA00092121
  condition_sets:
  - number: 1
    conditions:
    - condition_type: FUNFAM
      value: 3.10.20.30:FF:000003
      curie: CATH.FunFam:3.10.20.30:FF:000003
      label: Developmentally-regulated GTP-binding protein 1
      negated: false
    - condition_type: TAXON
      value: Fungi
      curie: NCBITaxon:4751
      label: Fungi
      negated: false
    notes: Yeast Rbg1 (P39729) and Rbg2 (P53295) both carry this FunFam.
  go_annotations:
  - go_id: GO:1903833
    go_label: positive regulation of cellular response to amino acid starvation
    aspect: BP
  entries:
  - id: 3.10.20.30:FF:000003
    type: FUNFAM
    label: Developmentally-regulated GTP-binding protein 1
    appears_in_condition_sets:
    - 1
  retrieved_date: '2026-11-09'
  withdrawn: true
review_summary: >-
  UniProt returned 404 for this rule on 2026-11-09. The condition set recorded is that of the last
  version reviewed. The family is not unrelated to the process: the two yeast members of the FunFam,
  Rbg1 and Rbg2, are annotated by SGD to GO:0034198 cellular response to amino acid starvation with
  genetic-interaction evidence. The rule asserted the regulation term GO:1903833 rather than GO:0034198.
action: DEPRECATE
action_rationale: The rule has been withdrawn by UniProt.
suggested_modifications:
- >-
  No change to make: the rule is withdrawn. If it were re-derived, the curated term on the yeast members
  is GO:0034198 cellular response to amino acid starvation.
annotation_assessments:
- annotation_kind: GO_TERM
  value: GO:1903833
  label: positive regulation of cellular response to amino acid starvation
  assessment: UNDECIDED
  notes: >-
    QuickGO: P39729 (RBG1) and P53295 (RBG2) GO:0034198 cellular response to amino acid starvation,
    IGI, PMID:23899355, assigned by SGD. Neither has a curated annotation to GO:1903833; in yeast
    the experimental annotations to GO:1903833 are on GCN2, GCN3 and GCN4. UniProtKB P39729 and P53295
    both list FunFam 3.10.20.30:FF:000003.
confidence: 0.9
corrections:
- date: '2026-11-10'
  withdrawn_claim: >-
    No literature connects developmentally-regulated GTP-binding proteins to the amino acid starvation
    response.
  correction: >-
    Both yeast members of the FunFam carry a curated annotation to the cellular response to amino
    acid starvation.
  error_type: REFUTED_BY_CURATED_ANNOTATION
  evidence:
  - 'QuickGO: P39729 GO:0034198 IGI PMID:23899355 (SGD)'
  - 'QuickGO: P53295 GO:0034198 IGI PMID:23899355 (SGD)'
- date: '2026-11-10'
  withdrawn_claim: Zero protein coverage shows the rule is incorrectly specified.
  correction: Empty statistics on a newly created rule say nothing about its conditions.
  error_type: UNEXAMINED_RULE
  evidence:
  - 'Previous file: reviewed_protein_count 0, unreviewed_protein_count 0, no dates'
- date: '2026-11-10'
  withdrawn_claim: A recent creation date suggests the rule is experimental or problematic.
  correction: The age of a rule is not evidence about its correctness.
  error_type: OTHER
  evidence:
  - No evidence was given
- date: '2026-11-10'
  withdrawn_claim: Literature support is none, per the review's manual research file.
  correction: The review's own notes are not literature; the assessment is removed.
  error_type: UNSUPPORTED_SOURCE
  evidence:
  - Previous supported_by cited ARBA00092121-manual-research.md only