Agent-Based Model Derived from module 4 elements · 2 transitions

Agent-based LDL particle clearance and PCSK9 receptor-degradation model

Tracks a cohort of 100 extracellular apoB-100 LDL particles (apob_ligand) through LDLR-mediated clathrin endocytosis (ldlr_endocytosis) and lysosomal acid lipase cholesteryl-ester hydrolysis (lipa_ce_hydrolysis), gated by secreted PCSK9 chaperone activity (pcsk9_degradation).

Module: LDL receptor-mediated endocytic uptake — apoB-100 ligand, LDLR internalization and recycling, PCSK9 degradation control Source YAML: modules/ldl_receptor_mediated_endocytosis.yaml

Compartment Trafficking & Discrete Cargo Routing

t = 24 / 24

Cargo Occupancy Trajectory (t = 0 .. 24)

Derived Transition Rules & Effective Flux Rates

From Stage To Stage Predicate Modulators / Competing Branches Effective Rate