p38 cascade as a Boolean network
The module's connections read as a signed regulatory graph and translated by ai-gene-review module-to-bnet with the default rule (active when any activator is active and no inhibitor is). Its one loop is p38 output inducing the MKP-1/DUSP1 phosphatase that dephosphorylates p38.
Boxes are steps of the moduleEach is either ON (filled) or OFF. Grey arrows activate; orange flat-headed lines inhibit.
Pick a scenario, press RunSteps switch one at a time, at random, whenever their inputs say they should: the asynchronous update.
Click a box to lock itCycle free → locked ON → locked OFF, to knock a step out or force it on. The read-out updates at once.
Where it ends upEvery possible end state is computed exhaustively. One steady state, or a cycle that never settles: in a Boolean model, a transient pulse.
Scenarios curated in the module, checked in validation
Wiring
ON
OFF
locked
input
activates
inhibits
removed in scenario
Where it ends up
Timeline one column per update, newest on the right
Update rules
Generated from the module's connections. A step is ON when any activator is ON and no inhibitor is (the default), unless the module declares activation_logic for it. A regulator that logic deliberately leaves out (omitted_regulators, a modulator rather than a switch) stays in the graph as a faint dotted edge and is named beside the rule.
BoolNet (.bnet) export