Nucleus and nuclear envelope lifecycle

The nucleus is bounded by a double-membrane envelope continuous with the endoplasmic reticulum and perforated by nuclear pore complexes. Pores are inserted into the intact envelope during interphase and, in cells with an open mitosis, the envelope and pores are disassembled at prophase and rebuilt around the daughter chromosomes, with ESCRT-III sealing the remaining holes. Throughout, the pores and the Ran system move proteins and RNAs between nucleus and cytoplasm. This umbrella module composes the modules for those stages by reference. The pore and Ran transport core is required in every eukaryote; the single-species descriptions are optional.

Organelle lifecycle umbrella (see projects/ORGANELLE_LIFECYCLES.md); stage roles follow the shared skeleton. Read as a satisfiability rule, the umbrella is satisfied when the pore and transport core is, and that core is partial (see its notes). The karyopherin import module, the Drosophila pore module and the human mRNA export module are optional references; the karyopherin module is not written as a PANTHER-grounded satisfiability rule. Not yet modelled, because no eukaryote-wide module exists: interphase pore insertion, nuclear envelope sealing by CHMP7, LEM2 and ESCRT-III (local PANTHER entries for the CHMP7 subfamily are vertebrate-only and for the LEMD2 subfamily mammal-only), mitotic disassembly and reassembly, which is absent from organisms with a closed mitosis, and the nuclear lamina, which is not universal.