fgf8a / fgf8b: annotation comparison
Generated by projects/DANRE_DUPLICATION/scripts/compare_pair.py; do not edit by hand.
Proteins
| fgf8a | fgf8b | |
|---|---|---|
| UniProt | O57341 | Q805B2 |
| Length (aa) | 210 | 212 |
Global alignment (BLOSUM62, gap -10/-0.5): 70.8% identity, 83.5% similarity over 212 alignment columns.
Existing annotations by term
Cells show evidence:action. — means the copy has no annotation to that exact term (it may still have a parent or child term).
MF
| Term | fgf8a | fgf8b |
|---|---|---|
| GO:0005104 fibroblast growth factor receptor binding | — | NAS:ACCEPT |
| GO:0005105 type 1 fibroblast growth factor receptor binding | IBA:ACCEPT | IBA:ACCEPT |
| GO:0005111 type 2 fibroblast growth factor receptor binding | IBA:ACCEPT | IBA:ACCEPT |
| GO:0008083 growth factor activity | IBA:ACCEPT IEA:ACCEPT |
IBA:ACCEPT IEA:ACCEPT |
BP
| Term | fgf8a | fgf8b |
|---|---|---|
| GO:0001708 cell fate specification | IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
— |
| GO:0001756 somitogenesis | IGI:KEEP_AS_NON_CORE | — |
| GO:0003007 heart morphogenesis | IMP:KEEP_AS_NON_CORE | — |
| GO:0003208 cardiac ventricle morphogenesis | IMP:KEEP_AS_NON_CORE | — |
| GO:0007368 determination of left/right symmetry | IGI:ACCEPT IMP:ACCEPT |
— |
| GO:0007389 pattern specification process | — | NAS:KEEP_AS_NON_CORE |
| GO:0007420 brain development | IMP:KEEP_AS_NON_CORE | — |
| GO:0007422 peripheral nervous system development | IGI:KEEP_AS_NON_CORE | — |
| GO:0007492 endoderm development | IDA:MODIFY IMP:KEEP_AS_NON_CORE |
— |
| GO:0007498 mesoderm development | IEA:KEEP_AS_NON_CORE IGI:KEEP_AS_NON_CORE |
IEA:MARK_AS_OVER_ANNOTATED |
| GO:0008284 positive regulation of cell population proliferation | IBA:KEEP_AS_NON_CORE | IBA:KEEP_AS_NON_CORE |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA:ACCEPT | IBA:ACCEPT NAS:ACCEPT |
| GO:0009880 embryonic pattern specification | IGI:KEEP_AS_NON_CORE | — |
| GO:0009887 animal organ morphogenesis | IMP:KEEP_AS_NON_CORE | — |
| GO:0009952 anterior/posterior pattern specification | IEA:KEEP_AS_NON_CORE IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
IEA:MARK_AS_OVER_ANNOTATED |
| GO:0009953 dorsal/ventral pattern formation | IBA:KEEP_AS_NON_CORE IDA:KEEP_AS_NON_CORE IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
IBA:MARK_AS_OVER_ANNOTATED |
| GO:0010002 cardioblast differentiation | IMP:ACCEPT | — |
| GO:0014709 positive regulation of somitomeric trunk muscle development | IMP:KEEP_AS_NON_CORE | — |
| GO:0021549 cerebellum development | IMP:ACCEPT | — |
| GO:0021555 midbrain-hindbrain boundary morphogenesis | IGI:ACCEPT | — |
| GO:0021571 rhombomere 5 development | IGI:KEEP_AS_NON_CORE | — |
| GO:0021572 rhombomere 6 development | IGI:KEEP_AS_NON_CORE | — |
| GO:0021588 cerebellum formation | IMP:ACCEPT | — |
| GO:0021703 locus ceruleus development | IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
— |
| GO:0022008 neurogenesis | IBA:KEEP_AS_NON_CORE | IBA:KEEP_AS_NON_CORE |
| GO:0030177 positive regulation of Wnt signaling pathway | IGI:UNDECIDED | — |
| GO:0030182 neuron differentiation | IMP:KEEP_AS_NON_CORE | — |
| GO:0030334 regulation of cell migration | IBA:KEEP_AS_NON_CORE | IBA:KEEP_AS_NON_CORE |
| GO:0030335 positive regulation of cell migration | IGI:KEEP_AS_NON_CORE | — |
| GO:0030878 thyroid gland development | IMP:KEEP_AS_NON_CORE | — |
| GO:0030901 midbrain development | IGI:ACCEPT IMP:ACCEPT |
— |
| GO:0030902 hindbrain development | IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
— |
| GO:0030903 notochord development | IGI:KEEP_AS_NON_CORE | — |
| GO:0030916 otic vesicle formation | IDA:KEEP_AS_NON_CORE IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
— |
| GO:0030917 midbrain-hindbrain boundary development | IMP:ACCEPT | NAS:KEEP_AS_NON_CORE |
| GO:0031076 embryonic camera-type eye development | IMP:KEEP_AS_NON_CORE | — |
| GO:0035050 embryonic heart tube development | IGI:KEEP_AS_NON_CORE | — |
| GO:0042664 negative regulation of endodermal cell fate specification | IDA:KEEP_AS_NON_CORE IEA:KEEP_AS_NON_CORE IGI:KEEP_AS_NON_CORE |
IEA:REMOVE |
| GO:0043049 otic placode formation | IGI:ACCEPT IMP:ACCEPT |
— |
| GO:0043410 positive regulation of MAPK cascade | IBA:ACCEPT | IBA:ACCEPT |
| GO:0046850 regulation of bone remodeling | IEP:MARK_AS_OVER_ANNOTATED IMP:KEEP_AS_NON_CORE |
— |
| GO:0048263 determination of dorsal identity | IDA:KEEP_AS_NON_CORE | — |
| GO:0048339 paraxial mesoderm development | IGI:KEEP_AS_NON_CORE | — |
| GO:0048665 neuron fate specification | IGI:UNDECIDED | — |
| GO:0048702 embryonic neurocranium morphogenesis | IGI:KEEP_AS_NON_CORE | — |
| GO:0048705 skeletal system morphogenesis | IMP:KEEP_AS_NON_CORE | — |
| GO:0048709 oligodendrocyte differentiation | IGI:UNDECIDED | — |
| GO:0048839 inner ear development | IMP:KEEP_AS_NON_CORE | — |
| GO:0051146 striated muscle cell differentiation | IMP:KEEP_AS_NON_CORE | — |
| GO:0051216 cartilage development | IMP:KEEP_AS_NON_CORE | — |
| GO:0055011 atrial cardiac muscle cell differentiation | NOT IMP:ACCEPT | — |
| GO:0055012 ventricular cardiac muscle cell differentiation | IMP:KEEP_AS_NON_CORE | — |
| GO:0060037 pharyngeal system development | IGI:KEEP_AS_NON_CORE | — |
| GO:0060041 retina development in camera-type eye | IGI:KEEP_AS_NON_CORE | — |
| GO:0060059 embryonic retina morphogenesis in camera-type eye | IGI:KEEP_AS_NON_CORE | — |
| GO:0060271 cilium assembly | IGI:KEEP_AS_NON_CORE IMP:KEEP_AS_NON_CORE |
— |
| GO:0060788 ectodermal placode formation | IMP:KEEP_AS_NON_CORE | — |
| GO:0061053 somite development | IMP:KEEP_AS_NON_CORE | — |
| GO:0061195 taste bud formation | IMP:KEEP_AS_NON_CORE | — |
| GO:0061386 closure of optic fissure | IGI:KEEP_AS_NON_CORE | — |
| GO:0070121 Kupffer's vesicle development | IMP:ACCEPT | — |
| GO:0071599 otic vesicle development | IGI:KEEP_AS_NON_CORE | — |
CC
| Term | fgf8a | fgf8b |
|---|---|---|
| GO:0005576 extracellular region | IBA:ACCEPT IDA:ACCEPT IEA:ACCEPT ISS:ACCEPT |
IBA:ACCEPT IEA:ACCEPT |
| GO:0005737 cytoplasm | IBA:MARK_AS_OVER_ANNOTATED | IBA:MARK_AS_OVER_ANNOTATED |
| GO:0005764 lysosome | IDA:KEEP_AS_NON_CORE | — |
Core molecular functions
- fgf8a: GO:0005105 type 1 fibroblast growth factor receptor binding; GO:0008083 growth factor activity; GO:0008083 growth factor activity; GO:0008083 growth factor activity
- fgf8b: GO:0005105 type 1 fibroblast growth factor receptor binding