smad3a / smad3b: annotation comparison
Generated by projects/DANRE_DUPLICATION/scripts/compare_pair.py; do not edit by hand.
Proteins
| smad3a | smad3b | |
|---|---|---|
| UniProt | Q8AY15 | Q8AY16 |
| Length (aa) | 425 | 423 |
Global alignment (BLOSUM62, gap -10/-0.5): 94.1% identity, 97.9% similarity over 425 alignment columns.
Existing annotations by term
Cells show evidence:action. — means the copy has no annotation to that exact term (it may still have a parent or child term).
MF
| Term | smad3a | smad3b |
|---|---|---|
| GO:0000976 transcription cis-regulatory region binding | IEA:ACCEPT | IEA:ACCEPT |
| GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA:ACCEPT | IBA:ACCEPT |
| GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific | IBA:ACCEPT TAS:ACCEPT |
IBA:ACCEPT |
| GO:0005515 protein binding | IPI:REMOVE | IPI:REMOVE |
| GO:0043565 sequence-specific DNA binding | IPI:ACCEPT | — |
| GO:0070411 I-SMAD binding | IBA:ACCEPT | IBA:ACCEPT |
BP
| Term | smad3a | smad3b |
|---|---|---|
| GO:0001714 endodermal cell fate specification | IMP:KEEP_AS_NON_CORE | — |
| GO:0006355 regulation of DNA-templated transcription | IEA:ACCEPT IPI:ACCEPT |
IEA:ACCEPT |
| GO:0007179 transforming growth factor beta receptor signaling pathway | IBA:ACCEPT IMP:ACCEPT |
IBA:ACCEPT |
| GO:0007498 mesoderm development | IGI:KEEP_AS_NON_CORE | — |
| GO:0007501 mesodermal cell fate specification | IMP:KEEP_AS_NON_CORE | — |
| GO:0009653 anatomical structure morphogenesis | IBA:KEEP_AS_NON_CORE | IBA:KEEP_AS_NON_CORE |
| GO:0009880 embryonic pattern specification | IEA:KEEP_AS_NON_CORE | IEA:KEEP_AS_NON_CORE |
| GO:0009953 dorsal/ventral pattern formation | IEA:MARK_AS_OVER_ANNOTATED | IEA:MARK_AS_OVER_ANNOTATED |
| GO:0030154 cell differentiation | IBA:KEEP_AS_NON_CORE | IBA:KEEP_AS_NON_CORE |
| GO:0030509 BMP signaling pathway | IEA:MARK_AS_OVER_ANNOTATED | IEA:MARK_AS_OVER_ANNOTATED |
| GO:0032924 activin receptor signaling pathway | IBA:ACCEPT | IBA:ACCEPT |
| GO:0038092 nodal signaling pathway | TAS:ACCEPT | — |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IBA:ACCEPT | IBA:ACCEPT |
| GO:0060215 primitive hemopoiesis | IGI:KEEP_AS_NON_CORE | — |
| GO:0060395 SMAD protein signal transduction | IBA:ACCEPT | IBA:ACCEPT |
CC
| Term | smad3a | smad3b |
|---|---|---|
| GO:0005634 nucleus | IEA:ACCEPT | IEA:ACCEPT |
| GO:0005667 transcription regulator complex | IEA:ACCEPT TAS:ACCEPT |
IEA:ACCEPT |
| GO:0005737 cytoplasm | IEA:ACCEPT | IEA:ACCEPT |
| GO:0071144 heteromeric SMAD protein complex | IBA:ACCEPT | IBA:ACCEPT |
Core molecular functions
- smad3a: GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- smad3b: GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific