tmc2a / tmc2b: annotation comparison
Generated by projects/DANRE_DUPLICATION/scripts/compare_pair.py; do not edit by hand.
Proteins
| tmc2a | tmc2b | |
|---|---|---|
| UniProt | E7FFT2 | F1QZE9 |
| Length (aa) | 916 | 892 |
Global alignment (BLOSUM62, gap -10/-0.5): 68.0% identity, 78.5% similarity over 937 alignment columns.
Existing annotations by term
Cells show evidence:action. — means the copy has no annotation to that exact term (it may still have a parent or child term).
MF
| Term | tmc2a | tmc2b |
|---|---|---|
| GO:0005245 voltage-gated calcium channel activity | IBA:MODIFY | IBA:MODIFY |
| GO:0005262 calcium channel activity | ISS:ACCEPT | — |
| GO:0005515 protein binding | IPI:MODIFY | — |
| GO:0008381 mechanosensitive monoatomic ion channel activity | IBA:ACCEPT ISS:ACCEPT |
IBA:ACCEPT |
BP
| Term | tmc2a | tmc2b |
|---|---|---|
| GO:0034220 monoatomic ion transmembrane transport | IEA:MODIFY | IEA:MODIFY |
| GO:0042472 inner ear morphogenesis | — | IEP:REMOVE |
| GO:0048839 inner ear development | — | IEP:REMOVE |
| GO:0048882 lateral line development | IEP:REMOVE | — |
| GO:0048884 neuromast development | — | IEP:REMOVE |
| GO:0050910 detection of mechanical stimulus involved in sensory perception of sound | IBA:ACCEPT IGI:ACCEPT IGI:MODIFY |
IBA:ACCEPT IGI:MODIFY IMP:MODIFY |
| GO:0060005 vestibular reflex | IBA:KEEP_AS_NON_CORE | IBA:KEEP_AS_NON_CORE |
| GO:0060119 inner ear receptor cell development | IEP:REMOVE | — |
| GO:0070588 calcium ion transmembrane transport | IEA:ACCEPT | IEA:ACCEPT |
| GO:0071260 cellular response to mechanical stimulus | IMP:ACCEPT | — |
CC
| Term | tmc2a | tmc2b |
|---|---|---|
| GO:0005886 plasma membrane | IBA:ACCEPT IDA:ACCEPT IEA:ACCEPT |
IBA:ACCEPT IEA:ACCEPT |
| GO:0016020 membrane | IEA:ACCEPT | IEA:ACCEPT |
| GO:0032426 stereocilium tip | — | IDA:NEW |
Core molecular functions
- tmc2a: contributes to GO:0140135 mechanosensitive monoatomic cation channel activity
- tmc2b: contributes to GO:0140135 mechanosensitive monoatomic cation channel activity