Parasite immune modulators

Scoping GO curation of secreted host-modulating proteins, starting with vampire bat saliva

AI Gene Review · projects/PARASITE_IMMUNE_MODULATORS · 2026

Bottom line

  • Blood-feeders and parasites secrete proteins that blunt host clotting, inflammation and immunity.
  • We scoped the vampire bat (DESRO) Vampirome: 45 salivary transcripts → 35 UniProt accessions, all unreviewed TrEMBL.
  • The reviews moved to the sibling VAMPIROME project: 14 DESRO reviews, 11 complete. Non-bat parasites are not started.

From transcripts to reviews

What the reviewed saliva proteins are thought to do

Where the review work stands (VAMPIROME)

Action Rows
ACCEPT 64
MODIFY 29
UNDECIDED 21
MARK_AS_OVER_ANNOTATED 15
REMOVE 3
NEW (proposed) 4

132 GOA rows across 14 reviews in genes/DESRO/. UNDECIDED rows are propagated terms with no bat evidence either way: 10 on K9IMD0 (e.g. protease rows transferred from human LTF), 6 on the K9IUF6 ADAMTS1 fragment whose catalytic residues UniProt flags.

Status and next steps

  • ✅ Background, Table 4 extract and UniProt mapping (projects/VAMPIROME/).
  • ✅ 14 DESRO reviews under VAMPIROME; ⬜ finish K9IUF6, K9IWR0, K9J2R0; ⬜ CALCA.
  • ⬜ Remaining ~20 mapped candidates (lipocalins, serpins, cystatin, TIMPs).
  • ⬜ Non-bat parasites: fold into the PARASITES umbrella as its host-modulation sub-topic.

Read more: projects/PARASITE_IMMUNE_MODULATORS.md · projects/VAMPIROME.md · genes/DESRO/