VAMPIROME

IN_PROGRESS BIOLOGY_DOMAIN

Species: DESRO

Genes: K9IFT7 K9IFY6 K9IIP0 K9IJK6 K9IMD0 K9IUF6 K9IWC0 K9IWH5 K9IWR0 K9IWX5 K9IYM3 K9IZA2 K9J287 K9J2R0

VAMPIROME

Bottom line: blood feeding requires a vampire bat to keep blood flowing at
the bite site, and the Vampirome salivary-gland study exposed a secretome
enriched for anticoagulants, protease inhibitors, candidate vasodilators, and
immune modulators. Working from the
Vampirome transcriptome and proteome study, we mapped the reported transcripts
to UniProt, found that Desmodus rotundus has no Swiss-Prot entries at all in
this set, picked a 13-protein shortlist on hemostasis and immune relevance, and
reviewed them plus draculin (K9IMD0). Across 14 reviewed proteins there are 136
annotation rows: 66 ACCEPT, 27 MODIFY, 21 MARK_AS_OVER_ANNOTATED, 8
KEEP_AS_NON_CORE, 7 UNDECIDED, 4 NEW and 3 REMOVE. The 13 Table 4 shortlist
proteins are all TrEMBL entries with only electronic GOA rows, while draculin
is a reviewed Swiss-Prot seed with direct experimental rows; the UNDECIDED and
over-annotated calls are the honest result for a project dominated by homology
transfer from experiments on other mammals. Twelve of the 14 reviewed proteins
have final descriptions and synthesized core functions; K9IUF6 and K9J2R0
still need description and core-function synthesis, and the CALCA/vCGRP seed
is not yet reviewed because a
RefSeq/TSA transcriptome search
found no exact or one-mismatch match for the reported peptide.
Remaining DESRO work is tracked in
#3994.

We did this because saliva proteins of blood-feeding animals are annotated
almost entirely by homology to their host counterparts, which imports the
host's biology wholesale. The C1-inhibitor homolog K9IYM3 is the clearest case:
its serpin ancestry brought peptidase activity and proteolysis, both removed,
and blood coagulation, hemostasis and fibrinolysis, all marked over-annotated.

Overview

Project to curate vampire bat (Desmodus rotundus; UniProt code DESRO) salivary gland proteins that modulate host hemostasis and immunity, based on the Vampirome transcriptome/proteome study. This project cross-links with PARASITE_IMMUNE_MODULATORS for broader parasite immune modulators work.

Sources and project files

Reviewed seed gene (DESRO)

Unmapped DESRO peptide seeds

Vampirome candidates (prioritize Swiss-Prot)

Reviewed (Swiss-Prot)

None detected for DESRO in this candidate set (all mapped entries are UniProtKB unreviewed/TrEMBL).

Reviewed priority shortlist

Full mapped TrEMBL candidate pool

All mapped DESRO candidates below are UniProtKB unreviewed (TrEMBL); several of
these accessions also appear in the reviewed priority shortlist above.

Unmapped Vampirome transcripts (no TSA/UniProt hit yet)

STATUS

2026-01-21

2026-01-22

NOTES

2026-01-21

2026-01-22