VAMPIROME

Overview

Project to curate vampire bat (Desmodus rotundus; UniProt code DESRO) salivary gland proteins that modulate host hemostasis and immunity, based on the Vampirome transcriptome/proteome study. This project cross-links with PARASITE_IMMUNE_MODULATORS for broader parasite immune modulators work.

Slides

• Slides (Marp source: VAMPIROME-slides.md) — AI generated

Sources and project files

• Table 4 extract: projects/VAMPIROME/table4_extract.md
• UniProt mapping table: projects/VAMPIROME/uniprot_mapping.md
• UniProt mapping JSON: projects/VAMPIROME/uniprot_mapping.json
• Candidate list JSON (reviewed vs unreviewed): projects/VAMPIROME/uniprot_candidates.json
• Related project: projects/PARASITE_IMMUNE_MODULATORS.md

Seed Genes (DESRO)

• [x] Draculin (Lactotransferrin; UniProt: K9IMD0)
• [ ] CALCA

Vampirome candidates (prioritize Swiss-Prot)

Reviewed (Swiss-Prot)

None detected for DESRO in this candidate set (all mapped entries are UniProtKB unreviewed/TrEMBL).

Priority shortlist (start here; most immune/hemostasis relevant)

• [ ] t-plasminogen activator (UniProt: K9IJK6; entry K9IJK6_DESRO; transcript BatTrinityAbyss-499018)
• [ ] Kunitz-type protease inhibitor 2 (UniProt: K9IZA2; entry K9IZA2_DESRO; transcript BatTrinityAbyss-541822)
• [ ] Putative plasma protease c1 inhibitor (UniProt: K9IYM3; entry K9IYM3_DESRO; transcript DrSigp-SigP-532391)
• [ ] Deoxyribonuclease-1-like 1 (UniProt: K9J287; entry K9J287_DESRO; transcript BatTrinityAbyss-532109)
• [ ] C-C motif chemokine (UniProt: K9IFY6; entry K9IFY6_DESRO; transcript BatTrinityAbyss-506850)
• [ ] Lymphotoxin-alpha (UniProt: K9IWR0; entry K9IWR0_DESRO; transcript BatTrinityAbyss-86412)
• [ ] Beta-defensin 1 (UniProt: K9IFT7; entry K9IFT7_DESRO; transcript BatTrinityAbyss-401005)
• [ ] lysozyme (UniProt: K9IWH5; entry K9IWH5_DESRO; transcript BatTrinityAbyss-500942; gene LYZ)
• [ ] Tumor necrosis factor-inducible gene 6 protein (UniProt: K9IIP0; entry K9IIP0_DESRO; transcript BatTrinityAbyss-527888)
• [ ] A disintegrin and metalloproteinase with thrombospondin motifs 1 (UniProt: K9IUF6; entry K9IUF6_DESRO; transcript BatTrinityAbyss-517665)
• [ ] Natriuretic peptides B (UniProt: K9IWC0; entry K9IWC0_DESRO; transcript BatTrinityAbyss-538594)
• [ ] Putative scp crisp: scp-like extracellular (UniProt: K9IWX5; entry K9IWX5_DESRO; transcript BatTrinityAbyss-495870)
• [ ] Dipeptidyl peptidase 4 (UniProt: K9J2R0; entry K9J2R0_DESRO; transcript BatTrinityAbyss-561424)

Unreviewed (TrEMBL)

• [ ] 2-phosphoxylose phosphatase 1 (UniProt: K9IKM9; entry K9IKM9_DESRO; transcript BatTrinityAbyss-508800)
• [ ] 5'-nucleotidase domain-containing protein 1 (UniProt: K9IKC7; entry K9IKC7_DESRO; transcript BatTrinityAbyss-537653)
• [ ] A disintegrin and metalloproteinase with thrombospondin motifs 1 (UniProt: K9IUF6; entry K9IUF6_DESRO; transcript BatTrinityAbyss-517665)
• [ ] Acid sphingomyelinase-like phosphodiesterase (UniProt: K9IL01; entry K9IL01_DESRO; transcript BatTrinityAbyss-549118)
• [ ] Beta-defensin 1 (UniProt: K9IFT7; entry K9IFT7_DESRO; transcript BatTrinityAbyss-401005)
• [ ] C-C motif chemokine (UniProt: K9IFY6; entry K9IFY6_DESRO; transcript BatTrinityAbyss-506850)
• [ ] Deoxyribonuclease-1-like 1 (UniProt: K9J287; entry K9J287_DESRO; transcript BatTrinityAbyss-532109)
• [ ] Dipeptidyl peptidase 4 (UniProt: K9J2R0; entry K9J2R0_DESRO; transcript BatTrinityAbyss-561424)
• [ ] Epoxide hydrolase (UniProt: K9IKD6; entry K9IKD6_DESRO; transcript BatTrinityAbyss-508632)
• [ ] Kunitz-type protease inhibitor 2 (UniProt: K9IZA2; entry K9IZA2_DESRO; transcript BatTrinityAbyss-541822)
• [ ] Lymphotoxin-alpha (UniProt: K9IWR0; entry K9IWR0_DESRO; transcript BatTrinityAbyss-86412)
• [ ] Metalloproteinase inhibitor 1 (UniProt: K9IGJ9; entry K9IGJ9_DESRO; transcript BatTrinityAbyss-37180)
• [ ] Metalloproteinase inhibitor 3 (UniProt: K9IHC5; entry K9IHC5_DESRO; transcript BatTrinityAbyss-534229)
• [ ] Natriuretic peptides B (UniProt: K9IWC0; entry K9IWC0_DESRO; transcript BatTrinityAbyss-538594)
• [ ] Putative alpha-1-antichymotrypsin (UniProt: K9IXP7; entry K9IXP7_DESRO; transcript BatTrinityAbyss-518161)
• [ ] Putative cystatin-m (UniProt: K9IWH8; entry K9IWH8_DESRO; transcript BatTrinityAbyss-41885)
• [ ] Putative disintegrin and metalloproteinase (UniProt: K9IZP9; entry K9IZP9_DESRO; transcript BatTrinityAbyss-521171)
• [ ] Putative iggfc-binding protein (UniProt: K9J450; entry K9J450_DESRO; transcript DrSigp-SigP-495835)
• [ ] Putative neuroserpin is a inhibitory member of (UniProt: K9J0L7; entry K9J0L7_DESRO; transcript BatTrinityAbyss-548577)
• [ ] Putative pituitary adenylate cyclase-activating (UniProt: K9IGD6; entry K9IGD6_DESRO; transcript BatTrinityAbyss-500584)
• [ ] Putative plasma protease c1 inhibitor (UniProt: K9IYM3; entry K9IYM3_DESRO; transcript DrSigp-SigP-532391)
• [ ] Putative salivary lipocalin (UniProt: K9IRT4; entry K9IRT4_DESRO; transcript BatTrinityAbyss-466603)
• [ ] Putative salivary lipocalin (UniProt: K9IHB8; entry K9IHB8_DESRO; transcript BatTrinityAbyss-495622)
• [ ] Putative salivary lipocalin (UniProt: K9IWR5; entry K9IWR5_DESRO; transcript BatTrinityAbyss-495624)
• [ ] Putative salivary lipocalin (UniProt: K9IQU6; entry K9IQU6_DESRO; transcript BatTrinityAbyss-495626)
• [ ] Putative salivary lipocalin (UniProt: K9IWP0; entry K9IWP0_DESRO; transcript BatTrinityAbyss-495631)
• [ ] Putative salivary lipocalin (UniProt: K9IYU4; entry K9IYU4_DESRO; transcript BatTrinityAbyss-496761)
• [ ] Putative scp crisp: scp-like extracellular (UniProt: K9IWX5; entry K9IWX5_DESRO; transcript BatTrinityAbyss-495870)
• [ ] Putative secreted mucin (UniProt: K9IGW6; entry K9IGW6_DESRO; transcript DrSigp-SigP-36965)
• [ ] Putative secreted protein precursor (UniProt: K9IFW5; entry K9IFW5_DESRO; transcript BatTrinityAbyss-36340)
• [ ] Putative serpin (UniProt: K9IJG1; entry K9IJG1_DESRO; transcript BatTrinityAbyss-25903)
• [ ] Serpin B6 (UniProt: K9J5D5; entry K9J5D5_DESRO; transcript BatTrinityAbyss-543253)
• [ ] Tumor necrosis factor-inducible gene 6 protein (UniProt: K9IIP0; entry K9IIP0_DESRO; transcript BatTrinityAbyss-527888)
• [ ] lysozyme (UniProt: K9IWH5; entry K9IWH5_DESRO; transcript BatTrinityAbyss-500942; gene LYZ)
• [ ] t-plasminogen activator (UniProt: K9IJK6; entry K9IJK6_DESRO; transcript BatTrinityAbyss-499018)

Unmapped Vampirome transcripts (no TSA/UniProt hit yet)

• vCGRP (calcitonin gene-related peptide-like; vasodilatory peptide). Reported peptide sequence:
  SCNTATCVTHRLAGLLSRSGGVVSSDFTPTDTGSNSY (Toxins 2019, Kakumanu et al.). Mapping to
  DESRO transcript/UniProt pending.
• BatTrinityAbyss-321620
• BatTrinityAbyss-429618
• BatTrinityAbyss-489254
• BatTrinityAbyss-499100
• BatTrinityAbyss-499228
• BatTrinityAbyss-500441
• BatTrinityAbyss-509950
• BatTrinityAbyss-523646
• BatTrinityAbyss-8258
• DrSigp-SigP-210264

STATUS

2026-01-21

• [x] Create Vampirome project structure and cross-link to PARASITE_IMMUNE_MODULATORS
• [x] Import Table 4 extract and UniProt mapping artifacts
• [x] Build candidate list with Swiss-Prot prioritization (none found)
• [x] Select priority shortlist (13 candidates)
• [ ] Expand seed list with any additional vampire bat modulators supplied by user
• [x] Fetch UniProt/GOA data for prioritized candidates
• [x] Deep research (falcon) for 13 shortlisted candidates
• [ ] Review existing annotations (annotation-reviewer)
• [ ] Synthesize core functions

2026-01-22

• [x] Add core_functions and descriptions for Draculin and three priority candidates
• [x] Add deep-research support snippets for core functions where available
• [x] Create notes files for Draculin (K9IMD0), K9IZA2, K9IYM3, and K9J287
• [x] Create notes files for remaining shortlist candidates (K9IJK6, K9IFY6, K9IWR0, K9IFT7, K9IWH5, K9IIP0, K9IUF6, K9IWC0, K9IWX5, K9J2R0)

NOTES

2026-01-21

• Created VAMPIROME project and moved Vampirome artifacts into projects/VAMPIROME/.
• UniProt mapping indicates all current DESRO candidates are UniProtKB unreviewed (TrEMBL); no Swiss-Prot entries detected.
• Cross-link with projects/PARASITE_IMMUNE_MODULATORS.md added.
• Selected a 13-gene priority shortlist focused on hemostasis/immune modulation and fetched UniProt/GOA data (K9IJK6, K9IZA2, K9IYM3, K9J287, K9IFY6, K9IWR0, K9IFT7, K9IWH5, K9IIP0, K9IUF6, K9IWC0, K9IWX5, K9J2R0).
• Falcon deep-research completed for all 13 shortlisted candidates; needed extended timeouts for some runs.
• Completed annotation review for Draculin (K9IMD0 / LTF).
• Completed annotation reviews for K9IJK6, K9IZA2, K9IYM3, K9J287, and K9IWR0.
• Completed annotation reviews for K9IFT7, K9IWH5, K9IIP0, K9IUF6, and K9IWC0.
• Completed annotation reviews for K9IWX5 and K9J2R0.

2026-01-22

• Added core_functions/description edits for Draculin (K9IMD0), K9IZA2, K9IYM3, and K9J287.
• Added deep-research support snippets for core functions where available.
• Created notes files for K9IMD0, K9IZA2, K9IYM3, and K9J287.
• Created notes files for remaining shortlisted candidates (K9IJK6, K9IFY6, K9IWR0, K9IFT7, K9IWH5, K9IIP0, K9IUF6, K9IWC0, K9IWX5, K9J2R0).
• Started CALCA/vCGRP mapping via transcriptome search; no peptide matches in RefSeq or TSA GABZ01 (see CALCA-bioinformatics RESULTS).