[subtype] Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|JAMM / MPN / ubiquitin binding
status=no_mapping scope= GO=[]
rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence.
[type] Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic
status=mapped scope=ok_for_propagation_to_go GO=[GO:0070552 BRISC complex]
rationale: This PN type covers noncatalytic BRISC subunits, so complex membership is the safe propagation target rather than catalytic DUB activity.
[group] Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex
status=mapped scope=ok_for_propagation_to_go GO=[GO:0070552 BRISC complex]
rationale: This PN group denotes BRISC complex members. The matching GO cellular-component term is BRISC complex.
[class] Ubiquitin Proteasome System|DUBs and UBL demodifiers
status=no_mapping scope= GO=[]
rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology.
[branch] Ubiquitin Proteasome System
status=no_mapping scope= GO=[]
rationale: Reviewed as the top-level UPS branch. It is a project taxonomy umbrella rather than a direct GO assertion; UPS propagation must come from manually curated child nodes.
PN row 2: Ubiquitin Proteasome System | Ubiquitin and UBL binding | DNA repair | BRISC complex component | idiosyncratic Ub binding / MPN
UniProt: Q15018
In branches: UPS
Signature domains: PMID: 19261749 (IPR037518)
Auxiliary domains: (none)
PN references (titles):
19261749
PN-node mapping records (path + ancestors):
[subtype] Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component|idiosyncratic Ub binding / MPN
status=no_mapping scope= GO=[]
rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence.
[type] Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component
status=no_mapping scope= GO=[]
rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology.
[group] Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair
status=mapped scope=ok_for_propagation_to_go GO=[GO:0006281 DNA repair]
rationale: This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate.
[class] Ubiquitin Proteasome System|Ubiquitin and UBL binding
status=context_only scope=too_broad_to_propagate GO=[GO:0140036 ubiquitin-modified protein reader activity]
rationale: This class records ubiquitin/UBL-reader context, but the subtree mixes ubiquitin, SUMO, UBL-domain, domain-architecture, catalytic, signaling, trafficking, and nucleic-acid process buckets. It is useful context, not a safe direct propagation.
[branch] Ubiquitin Proteasome System
status=no_mapping scope= GO=[]
rationale: Reviewed as the top-level UPS branch. It is a project taxonomy umbrella rather than a direct GO assertion; UPS propagation must come from manually curated child nodes.