PN dossier: CALR

• review_batch: proteostasis-batch-2026-06-06
• review_yaml: genes/human/CALR/CALR-ai-review.yaml
• PN workbook rows: 1

PN row 1: ER proteostasis | Glycoproteostasis | N-glycosylation system | Lectin chaperone

• UniProt: P27797
• In branches: ER
• PN-node mapping records (path + ancestors):
  • [type] ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
  • [group] ER proteostasis|Glycoproteostasis|N-glycosylation system
    status=mapped scope=ok_for_propagation_to_go GO=[GO:0006487 protein N-linked glycosylation]
    rationale: This PN group captures the ER N-glycosylation machinery that installs and processes N-linked glycans during proteostasis. GO protein N-linked glycosylation is the best current propagation target in the local cache.
  • [class] ER proteostasis|Glycoproteostasis
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
  • [branch] ER proteostasis
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

Projected GO annotations (1)

• GO:0006487 protein N-linked glycosylation | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=ER proteostasis|Glycoproteostasis|N-glycosylation system