PN dossier: CNPY3

• review_batch: proteostasis-batch-2026-06-07
• review_yaml: genes/human/CNPY3/CNPY3-ai-review.yaml
• PN workbook rows: 1

PN row 1: ER proteostasis | Chaperone | HSP90 system | HSP90 cochaperone | Folding of TLRs

• UniProt: Q9BT09
• In branches: ER
• PN-node mapping records (path + ancestors):
  • [subtype] ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|Folding of TLRs
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
  • [type] ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone
    status=mapped scope=ok_for_propagation_to_go GO=[GO:0051879 Hsp90 protein binding]
    rationale: This PN type groups ER HSP90/GRP94 cochaperones. Hsp90 protein binding is the shared mechanistic assertion.
  • [group] ER proteostasis|Chaperone|HSP90 system
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
  • [class] ER proteostasis|Chaperone
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
  • [branch] ER proteostasis
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

Projected GO annotations (1)

• GO:0051879 Hsp90 protein binding | scope=ok_for_propagation_to_go | goa_status=more_specific_than_existing_goa | from=ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone