PN dossier: COP1

• review_batch: proteostasis-batch-2026-06-07
• review_yaml: genes/human/COP1/COP1-ai-review.yaml
• PN workbook rows: 2

PN row 1: Ubiquitin Proteasome System | E3 ubiquitin and UBL ligases | Cul4A/Cul4B substrate adaptor | WD40 | other

• UniProt: Q8NHY2
• In branches: UPS
• Signature domains: (none)
• Auxiliary domains: IPR001680
• PN references (titles):
  • 17588513 rev
• PN-node mapping records (path + ancestors):
  • [subtype] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node.
  • [type] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node.
  • [group] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor
    status=mapped scope=ok_for_propagation_to_go GO=[GO:1990756 ubiquitin-like ligase-substrate adaptor activity]
    rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity.
  • [class] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases
    status=context_only scope=too_broad_to_propagate GO=[GO:0061630 ubiquitin protein ligase activity]
    rationale: This class is a genuine E3-ligase context, but its descendants include catalytic ligases, cullin scaffolds, substrate receptors, adaptors, cofactors, regulators, and UBL modifier systems. A class-level propagation would over-annotate.
  • [branch] Ubiquitin Proteasome System
    status=no_mapping scope= GO=[]
    rationale: Reviewed as the top-level UPS branch. It is a project taxonomy umbrella rather than a direct GO assertion; UPS propagation must come from manually curated child nodes.

PN row 2: Ubiquitin Proteasome System | E3 ubiquitin and UBL ligases | RING | RFWD | WD40

• UniProt: Q8NHY2
• In branches: UPS
• Signature domains: IPR001841
• Auxiliary domains: IPR001680
• PN references (titles):
  • 19489725 / rev
• PN-node mapping records (path + ancestors):
  • [subtype] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RFWD|WD40
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node.
  • [type] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RFWD
    status=no_mapping scope= GO=[]
    rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node.
  • [group] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING
    status=mapped scope=ok_for_propagation_to_go GO=[GO:0061630 ubiquitin protein ligase activity]
    rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity.
  • [class] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases
    status=context_only scope=too_broad_to_propagate GO=[GO:0061630 ubiquitin protein ligase activity]
    rationale: This class is a genuine E3-ligase context, but its descendants include catalytic ligases, cullin scaffolds, substrate receptors, adaptors, cofactors, regulators, and UBL modifier systems. A class-level propagation would over-annotate.
  • [branch] Ubiquitin Proteasome System
    status=no_mapping scope= GO=[]
    rationale: Reviewed as the top-level UPS branch. It is a project taxonomy umbrella rather than a direct GO assertion; UPS propagation must come from manually curated child nodes.

Projected GO annotations (2)

• GO:1990756 ubiquitin-like ligase-substrate adaptor activity | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor
• GO:0061630 ubiquitin protein ligase activity | scope=ok_for_propagation_to_go | goa_status=already_in_goa_exact | from=Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING