PN dossier: PELO

• review_batch: proteostasis-batch-2026-06-07c
• review_yaml: genes/human/PELO/PELO-ai-review.yaml
• PN workbook rows: 1

PN row 1: Translation | Cytosolic translation | Ribosome-associated QC | Ribosomal rescue

• UniProt: Q9BRX2
• In branches: TR
• PN-node mapping records (path + ancestors):
  • [type] Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue
    status=mapped scope=ok_for_propagation_to_go GO=[GO:0072344 rescue of stalled cytosolic ribosome]
    rationale: This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target.
  • [group] Translation|Cytosolic translation|Ribosome-associated QC
    status=mapped scope=ok_for_propagation_to_go GO=[GO:0006515 protein quality control for misfolded or incompletely synthesized proteins]
    rationale: The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.
  • [class] Translation|Cytosolic translation
    status=context_only scope=too_broad_to_propagate GO=[GO:0002181 cytoplasmic translation]
    rationale: The PN class Cytosolic translation is centered on the cytoplasmic translation apparatus and process, but it also houses supporting machinery such as ribosome biogenesis factors. The GO process term is a useful high-level label for the class, but propagating it to all members would over-annotate genes whose PN placement is through assembly or maturation context rather than core cytoplasmic translation.
  • [branch] Translation
    status=context_only scope=too_broad_to_propagate GO=[GO:0006412 translation]
    rationale: The PN Translation branch is organized around the translation apparatus and immediately associated cotranslational quality-control systems. GO translation is the closest high-level process label, but the PN branch also contains adjacent machinery such as ribosome biogenesis and nascent-chain handling. Keeping this relationship is useful for interpretation, but it is too broad to project safely onto every member.

Projected GO annotations (2)

• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Translation|Cytosolic translation|Ribosome-associated QC
• GO:0072344 rescue of stalled cytosolic ribosome | scope=ok_for_propagation_to_go | goa_status=already_in_goa_exact | from=Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue