Notes: Lysosome efflux permease that is essential for mTOR reactivation and ALR after prolonged starvation.
PN references (titles):
Membrane Trafficking in Autophagy - ScienceDirect
Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation | PNAS
PN-node mapping records (path + ancestors):
[group] Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products
status=mapped scope=ok_for_propagation_to_go GO=[GO:0007041 lysosomal transport]
rationale: This PN leaf denotes export of degradation products from the autolysosome during late-stage autophagic lysosome reformation. The closest current GO process term is lysosomal transport, because the key shared semantics are transport across the lysosomal/autolysosomal membrane rather than a specific cargo chemistry.
[class] Autophagy-Lysosome Pathway|Autophagic lysosome reformation
status=context_only scope=too_broad_to_propagate GO=[GO:0007040 lysosome organization]
rationale: Autophagic lysosome reformation is the lysosome-regeneration phase that follows autolysosome formation and cargo degradation. As a class, it is better aligned to lysosome organization than to generic autophagy, but the PN members are mechanistically mixed across membrane remodeling, tubulation, product efflux, and unknown late-stage roles, so class-level propagation would still over-annotate.
[branch] Autophagy-Lysosome Pathway
status=no_mapping scope= GO=[]
rationale: Reviewed as the top-level PN branch. It is a project taxonomy umbrella rather than a direct GO assertion; all propagation must come from manually curated child nodes.
Projected GO annotations (1)
GO:0007041 lysosomal transport | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Efflux of autophagy products